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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for OVOL1

Z-value: 1.51

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Transcription factors associated with OVOL1

Gene Symbol Gene ID Gene Info
OVOL1
ENSG00000172818.10 OVOL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OVOL1hg38_v1_chr11_+_65787056_657870750.188.3e-03Click!

Activity profile of OVOL1 motif

Sorted Z-values of OVOL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of OVOL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_83709382 10.91 ENST00000520302.5
ENST00000520213.5
ENST00000439399.6
SNAP91
synaptosome associated protein 91
chr11_+_123430259 10.44 ENST00000533341.3
ENST00000635736.2
GRAMD1B
GRAM domain containing 1B
chr18_-_5543960 8.88 ENST00000400111.8
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr18_-_5544250 8.65 ENST00000540638.6
ENST00000342933.7
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr18_-_5543988 8.62 ENST00000341928.7
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr5_+_161850597 7.76 ENST00000634335.1
ENST00000635880.1
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr5_+_141359970 7.52 ENST00000522605.2
ENST00000622527.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr5_-_16508788 7.19 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr10_-_72088972 7.08 ENST00000317376.8
ENST00000412663.5
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr5_-_16508990 6.98 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr10_-_72088533 6.72 ENST00000373109.7
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr19_-_49442360 6.16 ENST00000600601.5
SLC17A7
solute carrier family 17 member 7
chr5_-_16508812 6.02 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr5_-_16508858 5.80 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr5_-_16508951 5.67 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr5_+_140882116 4.56 ENST00000289272.3
ENST00000409494.5
ENST00000617769.1
PCDHA13
protocadherin alpha 13
chr1_+_174877430 2.94 ENST00000392064.6
RABGAP1L
RAB GTPase activating protein 1 like
chr19_-_45792755 1.25 ENST00000377735.7
ENST00000270223.7
DMWD
DM1 locus, WD repeat containing
chr2_-_182522556 1.23 ENST00000435564.5
PDE1A
phosphodiesterase 1A
chr4_+_39406917 1.09 ENST00000257408.5
KLB
klotho beta
chr2_-_182522703 0.96 ENST00000410103.1
PDE1A
phosphodiesterase 1A
chr2_-_152099155 0.89 ENST00000637309.1
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr17_-_7242156 0.73 ENST00000571129.5
ENST00000571253.1
ENST00000573928.1
ENST00000302386.10
GABARAP
GABA type A receptor-associated protein
chr3_-_165837412 0.65 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
BCHE
butyrylcholinesterase
chr18_+_54269493 0.62 ENST00000579534.6
ENST00000406285.7
ENST00000577612.5
ENST00000579434.5
ENST00000583136.5
POLI
DNA polymerase iota
chr2_-_152099023 0.42 ENST00000201943.10
ENST00000427385.6
ENST00000539935.7
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr15_+_75043263 0.11 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 31.7 GO:0061709 reticulophagy(GO:0061709)
2.9 26.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
2.1 6.2 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.8 13.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 10.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 7.8 GO:0071420 cellular response to histamine(GO:0071420)
0.2 0.6 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 1.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 2.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 12.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.7 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 2.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 26.2 GO:0033270 paranode region of axon(GO:0033270)
0.8 6.2 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.5 31.7 GO:0005801 cis-Golgi network(GO:0005801)
0.2 7.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 10.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.7 GO:0097225 sperm midpiece(GO:0097225)
0.0 13.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.9 7.8 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.6 13.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 10.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.4 2.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 1.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 0.6 GO:0033265 acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.1 26.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 12.1 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 6.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 2.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.1 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 1.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions