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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PAX1_PAX9

Z-value: 3.92

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.14 PAX1
PAX9
ENSG00000198807.13 PAX9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg38_v1_chr14_+_36661852_36661939,
hg38_v1_chr14_+_36657560_36657594		-0.411.8e-10Click!
PAX1hg38_v1_chr20_+_21705651_21705673-0.405.3e-10Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_133805789 23.20 ENST00000678299.1
SRPRB
SRP receptor subunit beta
chr8_-_100953331 21.16 ENST00000353245.7
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr10_-_43409160 15.19 ENST00000337970.7
ENST00000682386.1
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr18_-_49491586 14.06 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr8_-_100952918 13.83 ENST00000395957.6
ENST00000395948.6
ENST00000457309.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr2_+_206765578 12.25 ENST00000403094.3
ENST00000402774.8
FASTKD2
FAST kinase domains 2
chr6_-_170584654 11.81 ENST00000443345.2
ENST00000614056.4
PDCD2
programmed cell death 2
chrX_-_154479253 10.51 ENST00000357360.4
LAGE3
L antigen family member 3
chr18_-_49492305 9.59 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr4_+_74365136 9.02 ENST00000244869.3
EREG
epiregulin
chr11_-_126268810 8.44 ENST00000332118.11
SRPRA
SRP receptor subunit alpha
chr8_-_23404076 8.03 ENST00000524168.1
ENST00000389131.8
ENST00000523833.2
ENST00000519243.1
LOXL2
lysyl oxidase like 2
chr6_-_170584581 7.75 ENST00000392090.6
ENST00000542896.5
ENST00000453163.6
ENST00000537445.5
ENST00000541970.6
PDCD2
programmed cell death 2
chr22_-_17773976 6.96 ENST00000317361.11
BID
BH3 interacting domain death agonist
chr17_+_78378633 5.75 ENST00000262764.11
ENST00000589689.5
ENST00000592043.5
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr4_+_122826679 4.81 ENST00000264498.8
FGF2
fibroblast growth factor 2
chr17_+_39200507 4.67 ENST00000678573.1
RPL19
ribosomal protein L19
chr12_+_131929194 4.65 ENST00000443358.6
PUS1
pseudouridine synthase 1
chr17_+_39200334 4.38 ENST00000579260.5
ENST00000582193.5
RPL19
ribosomal protein L19
chr17_+_39200275 4.33 ENST00000225430.9
RPL19
ribosomal protein L19
chr17_+_39200302 4.03 ENST00000579374.5
RPL19
ribosomal protein L19
chr7_+_142770960 3.46 ENST00000632805.1
ENST00000633969.1
ENST00000539842.6
PRSS2
serine protease 2
chr4_+_122826824 3.21 ENST00000608478.1
ENST00000644866.2
FGF2
fibroblast growth factor 2
chr2_-_162074182 3.20 ENST00000360534.8
DPP4
dipeptidyl peptidase 4
chr3_-_25783434 3.14 ENST00000396649.7
ENST00000280700.10
ENST00000428257.5
NGLY1
N-glycanase 1
chrX_+_149540968 3.13 ENST00000423421.5
ENST00000423540.6
ENST00000434353.6
ENST00000393985.8
ENST00000514208.5
EOLA1
endothelium and lymphocyte associated ASCH domain 1
chr3_-_25783381 3.06 ENST00000308710.9
ENST00000676225.1
NGLY1
N-glycanase 1
chr2_-_162074394 3.01 ENST00000676810.1
DPP4
dipeptidyl peptidase 4
chr16_-_85688912 2.96 ENST00000253462.8
GINS2
GINS complex subunit 2
chr9_+_33750669 2.88 ENST00000361005.10
ENST00000342836.9
ENST00000429677.8
PRSS3
serine protease 3
chr12_+_131929219 2.71 ENST00000322060.9
PUS1
pseudouridine synthase 1
chr2_+_27212320 2.70 ENST00000405489.7
ATRAID
all-trans retinoic acid induced differentiation factor
chr17_+_41812974 2.39 ENST00000321562.9
FKBP10
FKBP prolyl isomerase 10
chr14_+_64388296 2.39 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr17_-_41812586 2.22 ENST00000355468.7
ENST00000590496.1
P3H4
prolyl 3-hydroxylase family member 4 (inactive)
chr19_-_38847423 2.10 ENST00000647557.1
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr12_-_101407727 2.00 ENST00000539055.5
ENST00000551688.1
ENST00000551671.5
ENST00000261636.13
ARL1
ADP ribosylation factor like GTPase 1
chr7_-_144835981 1.83 ENST00000360057.7
ENST00000378099.7
ENST00000639328.1
TPK1
thiamin pyrophosphokinase 1
chr2_-_162074050 1.79 ENST00000676768.1
DPP4
dipeptidyl peptidase 4
chr6_-_132624275 1.35 ENST00000367931.1
TAAR2
trace amine associated receptor 2
chr14_-_91417805 1.25 ENST00000389857.11
ENST00000553403.1
CCDC88C
coiled-coil domain containing 88C
chr3_+_15206179 0.85 ENST00000253693.7
CAPN7
calpain 7
chr11_-_126268913 0.82 ENST00000532259.1
SRPRA
SRP receptor subunit alpha
chr12_+_57434778 0.71 ENST00000309668.3
INHBC
inhibin subunit beta C
chrX_+_149781930 0.57 ENST00000243314.5
MAGEA9
MAGE family member A9
chr6_-_137045026 0.11 ENST00000367748.4
IL20RA
interleukin 20 receptor subunit alpha

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.3 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
2.7 35.0 GO:0090168 Golgi reassembly(GO:0090168)
2.5 7.4 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
2.2 19.6 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
1.3 9.0 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
1.1 5.7 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.1 8.0 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
1.1 8.0 GO:0036343 psychomotor behavior(GO:0036343)
0.6 1.8 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.6 2.4 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.5 7.0 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.4 6.2 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.4 3.0 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.3 17.4 GO:0097421 liver regeneration(GO:0097421)
0.3 8.0 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.2 2.0 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 32.9 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 2.7 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.2 15.2 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 14.0 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 2.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 2.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 10.5 GO:0008033 tRNA processing(GO:0008033)
0.0 0.8 GO:0097264 self proteolysis(GO:0097264)
0.0 2.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 3.5 GO:0030574 collagen catabolic process(GO:0030574)
0.0 2.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.3 GO:0031648 protein destabilization(GO:0031648)
0.0 0.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 32.5 GO:0005785 signal recognition particle receptor complex(GO:0005785)
2.1 10.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.8 8.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.7 3.0 GO:0000811 GINS complex(GO:0000811)
0.4 41.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 12.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 35.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 15.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 7.0 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 8.0 GO:0005604 basement membrane(GO:0005604)
0.1 2.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 2.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 3.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 5.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 7.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 17.0 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 32.5 GO:0005047 signal recognition particle binding(GO:0005047)
3.5 17.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
2.7 8.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
2.5 7.4 GO:0004730 pseudouridylate synthase activity(GO:0004730)
0.6 5.7 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.6 2.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 15.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 8.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 1.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.3 1.8 GO:0016778 diphosphotransferase activity(GO:0016778)
0.2 8.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 3.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.2 7.0 GO:0005123 death receptor binding(GO:0005123)
0.2 2.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 12.3 GO:0019843 rRNA binding(GO:0019843)
0.1 9.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 35.0 GO:0044325 ion channel binding(GO:0044325)
0.1 23.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 6.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 3.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 35.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 7.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 9.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 8.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 20.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 35.0 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.4 8.0 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 64.2 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 7.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 8.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 9.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 3.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 3.5 REACTOME DEFENSINS Genes involved in Defensins
0.1 17.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 0.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 5.7 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 4.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors