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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PAX4

Z-value: 5.09

Motif logo

Transcription factors associated with PAX4

Gene Symbol Gene ID Gene Info
ENSG00000106331.17 PAX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX4hg38_v1_chr7_-_127618137_1276181450.161.6e-02Click!

Activity profile of PAX4 motif

Sorted Z-values of PAX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_32439866 35.73 ENST00000374982.5
ENST00000395388.7
major histocompatibility complex, class II, DR alpha
chr4_-_83109843 29.69 ENST00000411416.6
placenta associated 8
chr1_+_26317950 27.46 ENST00000374213.3
CD52 molecule
chr6_+_32637419 27.35 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr2_-_136118142 26.29 ENST00000241393.4
C-X-C motif chemokine receptor 4
chr22_-_17219571 25.43 ENST00000610390.4
adenosine deaminase 2
chr22_-_17219424 24.86 ENST00000649540.1
ENST00000399837.8
ENST00000543038.1
adenosine deaminase 2
chr2_-_136116165 24.81 ENST00000409817.1
C-X-C motif chemokine receptor 4
chr6_+_31586269 22.63 ENST00000438075.7
leukocyte specific transcript 1
chr6_+_31586124 20.66 ENST00000418507.6
ENST00000376096.5
ENST00000376099.5
ENST00000376110.7
leukocyte specific transcript 1
chr6_-_25042003 20.16 ENST00000510784.8
RHO family interacting cell polarization regulator 2
chr11_+_1853049 19.33 ENST00000311604.8
lymphocyte specific protein 1
chr22_+_22887780 18.58 ENST00000532223.2
ENST00000526893.6
ENST00000531372.1
immunoglobulin lambda like polypeptide 5
chr6_+_32637396 17.36 ENST00000395363.5
ENST00000496318.5
ENST00000343139.11
major histocompatibility complex, class II, DQ alpha 1
chr1_-_153375591 17.28 ENST00000368737.5
S100 calcium binding protein A12
chr7_+_80638662 16.65 ENST00000394788.7
CD36 molecule
chr7_+_80638510 15.47 ENST00000433696.6
ENST00000538969.5
ENST00000544133.5
CD36 molecule
chr7_+_80638633 13.45 ENST00000447544.7
ENST00000482059.6
CD36 molecule
chr19_+_54630497 12.19 ENST00000396332.8
ENST00000427581.6
leukocyte immunoglobulin like receptor B1
chrY_+_2841594 11.78 ENST00000250784.13
ribosomal protein S4 Y-linked 1
chr19_+_54630410 11.52 ENST00000396327.7
ENST00000324602.12
leukocyte immunoglobulin like receptor B1
chr6_+_31615215 11.47 ENST00000337917.11
ENST00000376059.8
allograft inflammatory factor 1
chr1_-_24964984 11.23 ENST00000338888.3
ENST00000399916.5
RUNX family transcription factor 3
chr16_-_28609992 10.32 ENST00000314752.11
sulfotransferase family 1A member 1
chr9_+_131228109 9.62 ENST00000498010.2
ENST00000476004.5
ENST00000528406.1
nucleoporin 214
chr6_+_31586835 9.61 ENST00000211921.11
leukocyte specific transcript 1
chr6_+_31586680 9.08 ENST00000339530.8
leukocyte specific transcript 1
chr18_-_55588535 9.01 ENST00000566286.5
ENST00000566279.5
ENST00000626595.2
ENST00000564999.5
ENST00000616053.4
ENST00000356073.8
transcription factor 4
chr19_-_54281145 8.86 ENST00000434421.5
ENST00000391749.4
leukocyte immunoglobulin like receptor B2
chr16_+_81779279 8.61 ENST00000564138.6
phospholipase C gamma 2
chr19_-_54281082 8.57 ENST00000314446.10
leukocyte immunoglobulin like receptor B2
chr1_+_101237009 8.54 ENST00000305352.7
sphingosine-1-phosphate receptor 1
chr17_+_45221993 8.45 ENST00000328118.7
formin like 1
chr18_-_55588184 8.35 ENST00000354452.8
ENST00000565908.6
ENST00000635822.2
transcription factor 4
chr17_+_45221854 8.31 ENST00000331495.8
formin like 1
chr18_-_55422492 7.68 ENST00000561992.5
ENST00000630712.2
transcription factor 4
chr6_+_31586859 7.22 ENST00000433492.5
leukocyte specific transcript 1
chr9_-_20622479 7.18 ENST00000380338.9
MLLT3 super elongation complex subunit
chr2_-_24328113 7.08 ENST00000622089.4
intersectin 2
chr16_-_28609976 6.89 ENST00000566189.5
sulfotransferase family 1A member 1
chr8_-_21913671 6.80 ENST00000523932.1
ENST00000276420.9
docking protein 2
chr16_+_69924984 6.54 ENST00000568684.1
WW domain containing E3 ubiquitin protein ligase 2
chr1_-_182391783 6.52 ENST00000331872.11
ENST00000339526.8
glutamate-ammonia ligase
chr22_-_31292445 6.36 ENST00000402249.7
ENST00000215912.10
ENST00000443175.1
ENST00000441972.5
phosphoinositide-3-kinase interacting protein 1
chr16_-_28610032 6.16 ENST00000567512.1
sulfotransferase family 1A member 1
chr6_+_15246054 6.10 ENST00000341776.7
jumonji and AT-rich interaction domain containing 2
chr1_-_182391323 6.03 ENST00000642379.1
glutamate-ammonia ligase
chr11_+_72114840 5.96 ENST00000622388.4
folate receptor gamma
chr1_-_151059561 5.68 ENST00000357235.6
ENST00000540998.5
CDC42 small effector 1
chr1_-_182391363 5.63 ENST00000417584.6
glutamate-ammonia ligase
chr17_+_16381083 5.48 ENST00000535788.1
ENST00000302182.8
ubiquitin B
chrX_+_47145200 5.47 ENST00000377604.8
RNA binding motif protein 10
chr10_+_112375196 5.44 ENST00000393081.6
acyl-CoA synthetase long chain family member 5
chrX_+_47145240 5.42 ENST00000628161.2
ENST00000345781.10
RNA binding motif protein 10
chr19_+_2977538 5.00 ENST00000453329.5
ENST00000482627.1
ENST00000246112.9
ENST00000452088.5
TLE family member 6, subcortical maternal complex member
chr1_-_1692724 4.90 ENST00000614300.4
ENST00000611123.1
ENST00000617444.5
solute carrier family 35 member E2B
chr3_-_197749688 4.57 ENST00000273582.9
rubicon autophagy regulator
chr2_-_85612023 4.43 ENST00000409734.3
ENST00000306336.6
chromosome 2 open reading frame 68
chr2_+_99181173 4.32 ENST00000338148.8
ENST00000409145.5
mitochondrial ribosomal protein L30
chr19_-_49119092 4.32 ENST00000408991.4
chromosome 19 open reading frame 73
chr7_+_73433761 4.24 ENST00000344575.5
frizzled class receptor 9
chr19_+_54593619 4.09 ENST00000251372.8
ENST00000453777.1
leukocyte immunoglobulin like receptor A1
chrX_-_132489954 4.05 ENST00000370844.5
muscleblind like splicing regulator 3
chr4_+_47485268 4.04 ENST00000273859.8
ENST00000504445.1
ATPase phospholipid transporting 10D (putative)
chr3_-_21751189 4.00 ENST00000281523.8
zinc finger protein 385D
chr1_+_12063357 3.89 ENST00000417814.3
TNF receptor superfamily member 8
chr8_-_144428502 3.86 ENST00000531032.5
ENST00000530790.5
ENST00000292510.6
ENST00000533806.5
ENST00000377348.6
VPS28 subunit of ESCRT-I
chr2_+_104853259 3.83 ENST00000598623.1
ENST00000653688.1
ENST00000662784.1
ENST00000666977.1
ENST00000674056.1
novel transcript, sense overlapping POU3F3
POU class 3 homeobox 3
chr6_-_32128191 3.79 ENST00000453203.2
ENST00000375203.8
ENST00000375201.8
activating transcription factor 6 beta
chr16_-_28597042 3.77 ENST00000533150.5
ENST00000335715.9
sulfotransferase family 1A member 2
chr1_+_12063285 3.76 ENST00000263932.7
TNF receptor superfamily member 8
chrX_-_132489842 3.57 ENST00000436215.5
muscleblind like splicing regulator 3
chr18_-_55422306 3.50 ENST00000566777.5
ENST00000626584.2
transcription factor 4
chr18_-_5396265 3.41 ENST00000579951.2
erythrocyte membrane protein band 4.1 like 3
chr1_+_231241195 3.38 ENST00000436239.5
ENST00000366647.9
ENST00000416000.1
glyceronephosphate O-acyltransferase
chr8_+_41490396 3.25 ENST00000518270.5
ENST00000520817.5
golgin A7
chr18_-_63319987 3.21 ENST00000398117.1
BCL2 apoptosis regulator
chr6_+_132814566 3.15 ENST00000230050.4
ribosomal protein S12
chr8_+_22089140 3.06 ENST00000289921.8
family with sequence similarity 160 member B2
chr2_+_106487349 3.03 ENST00000643224.2
ENST00000416057.2
CD8b2 molecule
chr12_+_100503352 3.01 ENST00000551379.5
ENST00000188403.7
nuclear receptor subfamily 1 group H member 4
chr11_-_65606959 2.95 ENST00000532507.5
mitogen-activated protein kinase kinase kinase 11
chr6_+_29301701 2.95 ENST00000641895.1
olfactory receptor family 14 subfamily J member 1
chr19_+_14433284 2.93 ENST00000242783.11
protein kinase N1
chr5_-_94111627 2.89 ENST00000505869.5
ENST00000395965.8
ENST00000509163.5
family with sequence similarity 172 member A
chr1_-_151346806 2.77 ENST00000392746.7
regulatory factor X5
chr2_-_207624983 2.73 ENST00000448007.6
ENST00000432416.5
ENST00000411432.5
ENST00000458426.5
ENST00000406927.6
ENST00000425132.5
methyltransferase like 21A
chr1_+_21551260 2.67 ENST00000374832.5
alkaline phosphatase, biomineralization associated
chr16_+_50696999 2.57 ENST00000300589.6
nucleotide binding oligomerization domain containing 2
chr20_-_46364385 2.55 ENST00000243896.6
ENST00000543605.5
ENST00000372230.10
ENST00000317734.12
solute carrier family 35 member C2
chr17_+_7281711 2.49 ENST00000317370.13
ENST00000571308.5
solute carrier family 2 member 4
chr2_+_99141696 2.48 ENST00000650052.2
ENST00000409684.2
chromosome 2 open reading frame 15
chr16_+_67570741 2.39 ENST00000644753.1
ENST00000642819.1
ENST00000645306.1
CCCTC-binding factor
chr3_+_69084973 2.37 ENST00000478935.1
ADP ribosylation factor like GTPase 6 interacting protein 5
chr5_-_59586393 2.35 ENST00000505453.1
ENST00000360047.9
phosphodiesterase 4D
chr4_-_499102 2.34 ENST00000338977.5
ENST00000511833.3
zinc finger protein 721
chr18_-_63319729 2.31 ENST00000333681.5
BCL2 apoptosis regulator
chr2_+_104854104 2.29 ENST00000361360.4
POU class 3 homeobox 3
chr9_+_89605004 2.29 ENST00000252506.11
ENST00000375769.1
growth arrest and DNA damage inducible gamma
chr7_-_100158679 2.28 ENST00000456769.5
ENST00000316937.8
trafficking protein particle complex 14
chr10_+_113126670 2.25 ENST00000369389.6
transcription factor 7 like 2
chr9_+_121207774 2.23 ENST00000373823.7
gelsolin
chr19_+_3314403 2.23 ENST00000641145.1
nuclear factor I C
chr3_+_39384423 2.21 ENST00000645280.1
ENST00000643672.1
solute carrier family 25 member 38
chr3_+_9933805 2.20 ENST00000684493.1
ENST00000673935.2
ENST00000684181.1
ENST00000683189.1
ENST00000383811.8
ENST00000452070.6
ENST00000682642.1
ENST00000684659.1
ENST00000491527.2
ENST00000326434.9
ENST00000682783.1
ENST00000683835.1
ENST00000682570.1
cysteine rich with EGF like domains 1
chr8_+_41490553 2.15 ENST00000405786.2
ENST00000357743.9
golgin A7
chr17_+_1771688 2.11 ENST00000572048.1
ENST00000573763.1
serpin family F member 1
chr4_+_39182497 2.03 ENST00000509560.5
ENST00000512112.5
ENST00000399820.8
ENST00000506503.1
WD repeat domain 19
chr5_-_143403297 1.96 ENST00000415690.6
nuclear receptor subfamily 3 group C member 1
chr1_+_40691689 1.96 ENST00000427410.6
ENST00000447388.7
ENST00000425457.6
ENST00000453631.5
ENST00000456393.6
nuclear transcription factor Y subunit gamma
chr2_-_86861871 1.96 ENST00000390655.12
ENST00000393759.6
ENST00000349455.7
ENST00000331469.6
ENST00000393761.6
ENST00000431506.3
CD8b molecule
chr10_-_68332914 1.95 ENST00000358769.7
ENST00000495025.2
phenazine biosynthesis like protein domain containing
chr14_-_49586325 1.94 ENST00000557519.1
ENST00000396020.7
ENST00000554075.2
ENST00000245458.11
ribosomal protein S29
chr18_+_32091849 1.94 ENST00000261593.8
ENST00000578914.1
ring finger protein 138
chr3_+_39383337 1.93 ENST00000650617.1
ENST00000431510.1
ENST00000645630.1
solute carrier family 25 member 38
chr2_+_102355750 1.92 ENST00000233957.7
interleukin 18 receptor 1
chr9_-_120914549 1.91 ENST00000546084.5
TNF receptor associated factor 1
chr18_+_32190033 1.89 ENST00000269202.11
meprin A subunit beta
chr11_-_62601223 1.88 ENST00000527204.5
metastasis associated 1 family member 2
chr7_+_66921217 1.84 ENST00000341567.8
ENST00000607045.5
transmembrane protein 248
chr1_+_162069768 1.81 ENST00000530878.5
nitric oxide synthase 1 adaptor protein
chr20_-_53593829 1.81 ENST00000371471.7
zinc finger protein 217
chr2_+_203014842 1.78 ENST00000683969.1
ENST00000449802.5
neurobeachin like 1
chr5_+_163503075 1.78 ENST00000280969.9
methionine adenosyltransferase 2B
chr18_+_32190015 1.72 ENST00000581447.1
meprin A subunit beta
chr18_+_31447732 1.67 ENST00000257189.5
desmoglein 3
chr12_-_113135710 1.66 ENST00000446861.7
RAS protein activator like 1
chr1_-_8817633 1.62 ENST00000400908.7
arginine-glutamic acid dipeptide repeats
chr11_+_73264479 1.56 ENST00000393592.7
ENST00000540342.6
ENST00000679753.1
ENST00000542092.5
ENST00000349767.6
pyrimidinergic receptor P2Y6
chr2_+_102355881 1.49 ENST00000409599.5
interleukin 18 receptor 1
chr10_-_68332878 1.47 ENST00000309049.8
phenazine biosynthesis like protein domain containing
chr1_-_204494752 1.46 ENST00000684373.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
chr8_+_32548267 1.45 ENST00000356819.7
neuregulin 1
chr19_-_10309783 1.44 ENST00000403352.1
ENST00000403903.7
zinc finger GATA like protein 1
chrX_+_66164340 1.44 ENST00000441993.7
ENST00000419594.6
ENST00000425114.2
hephaestin
chrX_+_110944285 1.43 ENST00000425146.5
ENST00000446737.5
p21 (RAC1) activated kinase 3
chr4_+_159241016 1.41 ENST00000644902.1
Rap guanine nucleotide exchange factor 2
chr14_+_76151898 1.40 ENST00000557542.5
ENST00000556109.1
ENST00000557263.5
ENST00000261530.12
ENST00000312858.9
G-patch domain containing 2 like
chrX_+_16946650 1.39 ENST00000357277.8
RALBP1 associated Eps domain containing 2
chrX_-_31266857 1.38 ENST00000378702.8
ENST00000361471.8
dystrophin
chr12_-_13095628 1.38 ENST00000457134.6
ENST00000537302.5
germ cell associated 1
chr3_-_142448028 1.35 ENST00000392981.7
5'-3' exoribonuclease 1
chr7_-_138002017 1.33 ENST00000452463.5
ENST00000456390.5
ENST00000330387.11
cAMP responsive element binding protein 3 like 2
chr17_-_714709 1.30 ENST00000401468.7
ENST00000575100.2
ENST00000680069.1
ENST00000681902.1
ENST00000576019.6
ENST00000571456.2
ENST00000679361.1
ENST00000680241.1
ENST00000681917.1
ENST00000681133.1
ENST00000437048.7
ENST00000680128.1
ENST00000681154.1
ENST00000679961.1
ENST00000680970.1
ENST00000681295.1
ENST00000574029.6
ENST00000681317.1
ENST00000571805.6
ENST00000291074.10
VPS53 subunit of GARP complex
chr1_+_162069674 1.28 ENST00000361897.10
nitric oxide synthase 1 adaptor protein
chr17_-_35063648 1.27 ENST00000394597.7
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr22_-_16825404 1.26 ENST00000684488.1
XK related 3
chr3_+_119579676 1.26 ENST00000357003.7
ADP-ribosylarginine hydrolase
chr6_-_49787265 1.26 ENST00000304801.6
phosphoglycerate kinase 2
chr5_-_32444722 1.24 ENST00000265069.13
zinc finger RNA binding protein
chr12_-_113136224 1.23 ENST00000546530.5
ENST00000261729.9
RAS protein activator like 1
chr4_-_169010241 1.20 ENST00000504480.5
ENST00000306193.8
carbonyl reductase 4
chr1_+_152908538 1.19 ENST00000368764.4
involucrin
chr12_-_13095798 1.13 ENST00000396302.7
germ cell associated 1
chr4_+_74158099 1.12 ENST00000395759.6
ENST00000325278.7
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
chr9_+_127803208 1.12 ENST00000373225.7
ENST00000431857.5
folylpolyglutamate synthase
chr5_-_143403611 1.09 ENST00000394464.7
ENST00000231509.7
nuclear receptor subfamily 3 group C member 1
chrX_-_154295085 1.08 ENST00000617225.4
ENST00000619903.4
testis expressed 28
chr3_-_9880250 1.07 ENST00000423850.5
ENST00000336832.7
ENST00000675828.1
ENST00000618572.4
ENST00000455015.6
cell death inducing DFFA like effector c
chr12_-_44875647 1.05 ENST00000395487.6
neural EGFL like 2
chrX_+_77447387 1.03 ENST00000439435.3
fibroblast growth factor 16
chr7_-_130440848 1.03 ENST00000675803.1
ENST00000223208.10
ENST00000343969.10
ENST00000471201.6
ENST00000675649.1
ENST00000675168.1
ENST00000469826.2
ENST00000334451.6
ENST00000675962.1
ENST00000675563.1
ENST00000480206.2
ENST00000489512.5
ENST00000676243.1
ENST00000674539.1
ENST00000675935.1
centrosomal protein 41
chr6_+_20403679 1.01 ENST00000535432.2
E2F transcription factor 3
chr6_-_31730198 0.99 ENST00000375787.6
dimethylarginine dimethylaminohydrolase 2
chr1_+_40691749 0.96 ENST00000372654.5
nuclear transcription factor Y subunit gamma
chr12_+_64497968 0.93 ENST00000676593.1
ENST00000677093.1
TANK binding kinase 1
novel transcript
chr11_+_62123991 0.91 ENST00000533896.5
ENST00000278849.4
ENST00000394818.8
inner centromere protein
chr12_+_18262730 0.85 ENST00000675017.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr16_-_17470953 0.82 ENST00000261381.7
xylosyltransferase 1
chr8_-_38996466 0.79 ENST00000456845.6
ENST00000456397.7
ENST00000397070.6
ENST00000517872.1
TM2 domain containing 2
chr13_-_24922788 0.77 ENST00000381884.9
centromere protein J
chr19_-_52690533 0.71 ENST00000598322.2
novel zinc finger protein
chr19_+_49119531 0.70 ENST00000334186.9
PTPRF interacting protein alpha 3
chr12_-_18090141 0.69 ENST00000536890.1
RERG like
chr14_-_68793055 0.68 ENST00000439696.3
ZFP36 ring finger protein like 1
chr6_+_55174508 0.67 ENST00000370862.4
hypocretin receptor 2
chr10_-_69573416 0.64 ENST00000242462.5
neurogenin 3
chr19_-_52690478 0.61 ENST00000598536.5
ENST00000594682.6
ENST00000601257.5
zinc finger protein 83
chr17_-_44218406 0.57 ENST00000526094.5
ENST00000529383.5
ENST00000530828.1
upstream binding transcription factor
chr12_-_13095664 0.53 ENST00000337630.10
ENST00000545699.1
germ cell associated 1
chr10_+_113129285 0.47 ENST00000637574.1
transcription factor 7 like 2
chr5_+_77086682 0.47 ENST00000643365.1
ENST00000645183.1
ENST00000645374.1
ENST00000647364.1
ENST00000643848.1
ENST00000643603.1
ENST00000645459.1
ENST00000643269.1
ENST00000503969.6
ENST00000646262.1
ZBED3 antisense RNA 1
phosphodiesterase 8B
chr2_-_216695540 0.45 ENST00000233813.5
insulin like growth factor binding protein 5
chr4_+_139665768 0.44 ENST00000616265.4
ENST00000265498.6
ENST00000506797.5
microsomal glutathione S-transferase 2
chr7_-_138001794 0.43 ENST00000616381.4
ENST00000620715.4
cAMP responsive element binding protein 3 like 2
chr3_+_186666003 0.43 ENST00000232003.5
histidine rich glycoprotein
chr4_+_75514455 0.42 ENST00000508105.5
ENST00000311638.7
ENST00000380837.7
ENST00000507556.5
ENST00000504190.5
ENST00000507885.5
ENST00000502620.1
ENST00000514480.1
THAP domain containing 6
chr11_-_114595777 0.36 ENST00000375478.4
neurexophilin and PC-esterase domain family member 4
chr17_-_28370283 0.35 ENST00000226218.9
vitronectin
chr19_+_41549510 0.35 ENST00000407170.6
ENST00000601116.5
ENST00000595395.1
CEA cell adhesion molecule 21
novel transcript, sense intronic to CEACAM21
chr4_+_499194 0.35 ENST00000453061.7
ENST00000310340.9
ENST00000504346.5
ENST00000503111.5
ENST00000383028.8
ENST00000509768.1
phosphatidylinositol glycan anchor biosynthesis class G
chr1_+_172420681 0.35 ENST00000367727.9
chromosome 1 open reading frame 105
chr4_+_164754116 0.31 ENST00000507311.1
small integral membrane protein 31
chr8_+_32548210 0.28 ENST00000523079.5
ENST00000650919.1
neuregulin 1
chr11_-_59810750 0.26 ENST00000300151.5
mitochondrial ribosomal protein L16
chr19_-_49451793 0.25 ENST00000262265.10
PIH1 domain containing 1
chr6_+_138796081 0.23 ENST00000541398.7
epithelial cell transforming 2 like
chr9_-_120926752 0.19 ENST00000373887.8
TNF receptor associated factor 1
chr3_-_142448060 0.17 ENST00000264951.8
5'-3' exoribonuclease 1
chr9_-_5185628 0.14 ENST00000381641.4
ENST00000649639.1
insulin like 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.9 35.7 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
10.1 50.3 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
5.9 23.7 GO:2001191 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
5.1 51.1 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
5.1 45.6 GO:0072564 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
4.5 18.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
4.4 17.4 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
4.0 20.2 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
3.6 10.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
2.8 8.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
2.6 7.7 GO:0045553 TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556)
2.3 11.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
2.2 8.6 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
2.0 6.1 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
1.6 29.7 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
1.4 4.2 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
1.4 4.1 GO:0036233 glycine import(GO:0036233)
1.4 5.5 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
1.4 5.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.3 3.9 GO:2000397 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
1.2 19.0 GO:0051014 actin filament severing(GO:0051014)
1.2 27.1 GO:0006068 ethanol catabolic process(GO:0006068)
1.1 3.4 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
1.1 3.4 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.9 2.7 GO:0071529 cementum mineralization(GO:0071529)
0.8 3.1 GO:1903116 positive regulation of actin filament-based movement(GO:1903116) positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.8 3.0 GO:0038185 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.7 2.9 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.7 27.5 GO:0045730 respiratory burst(GO:0045730)
0.6 2.6 GO:0032499 detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.6 67.1 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.6 7.2 GO:0007379 segment specification(GO:0007379)
0.6 5.2 GO:1902527 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) fat pad development(GO:0060613) positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) positive regulation of protein monoubiquitination(GO:1902527)
0.5 1.5 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.5 5.0 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.5 2.4 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.5 1.4 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.5 3.2 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.4 11.2 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 1.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.4 17.7 GO:0050832 defense response to fungus(GO:0050832)
0.4 6.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.4 46.1 GO:0031295 T cell costimulation(GO:0031295)
0.4 2.0 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.4 1.6 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.4 2.4 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.4 3.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.4 3.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.4 6.0 GO:0015884 folic acid transport(GO:0015884)
0.3 1.0 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.3 3.0 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.3 1.3 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3 0.9 GO:0044565 dendritic cell proliferation(GO:0044565)
0.3 2.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279)
0.3 1.2 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.3 3.8 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.3 18.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 1.1 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.3 1.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.3 1.9 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.3 2.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.3 2.6 GO:0036066 pyrimidine nucleotide-sugar transport(GO:0015781) protein O-linked fucosylation(GO:0036066)
0.3 1.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.2 9.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 2.7 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.2 0.7 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.2 4.9 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 0.4 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.2 9.6 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 5.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 6.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 1.8 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 1.0 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.0 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 10.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 10.5 GO:0006968 cellular defense response(GO:0006968)
0.1 0.7 GO:0010840 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.1 4.0 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 1.6 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.8 GO:0061511 centriole elongation(GO:0061511)
0.1 1.2 GO:0044597 polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.1 2.5 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 2.3 GO:1900745 activation of MAPKKK activity(GO:0000185) positive regulation of p38MAPK cascade(GO:1900745)
0.1 5.7 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 27.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 0.3 GO:1903939 regulation of histone H3-K9 dimethylation(GO:1900109) negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.1 12.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 3.6 GO:1901998 toxin transport(GO:1901998)
0.1 4.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 2.0 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 1.9 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.1 1.4 GO:0006825 copper ion transport(GO:0006825)
0.0 2.2 GO:0003197 endocardial cushion development(GO:0003197)
0.0 1.0 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.6 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 2.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.6 GO:0060290 transdifferentiation(GO:0060290)
0.0 0.8 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 1.4 GO:0030317 sperm motility(GO:0030317)
0.0 1.3 GO:0032456 endocytic recycling(GO:0032456)
0.0 2.1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 2.2 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 2.7 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 0.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 80.4 GO:0042613 MHC class II protein complex(GO:0042613)
2.4 9.6 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
1.8 20.2 GO:0060171 stereocilium membrane(GO:0060171)
1.2 45.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.9 5.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.6 18.2 GO:0097386 glial cell projection(GO:0097386)
0.6 3.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.6 1.8 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.6 73.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.5 8.1 GO:0032059 bleb(GO:0032059)
0.4 11.5 GO:0001891 phagocytic cup(GO:0001891)
0.4 3.9 GO:0000813 ESCRT I complex(GO:0000813)
0.4 2.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.4 18.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.3 2.0 GO:0030991 intraciliary transport particle A(GO:0030991)
0.3 6.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 2.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 5.5 GO:0046930 pore complex(GO:0046930)
0.2 2.1 GO:0043203 axon hillock(GO:0043203)
0.2 16.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.9 GO:0000801 central element(GO:0000801)
0.2 2.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 2.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 3.4 GO:0033270 paranode region of axon(GO:0033270)
0.2 55.4 GO:0005770 late endosome(GO:0005770)
0.2 0.8 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.2 5.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 1.3 GO:1990745 EARP complex(GO:1990745)
0.2 17.4 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.2 0.4 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.2 2.2 GO:0030478 actin cap(GO:0030478)
0.2 27.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 1.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 32.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 20.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 4.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 2.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 7.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 2.6 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.9 GO:0001533 cornified envelope(GO:0001533)
0.1 1.9 GO:0035861 site of double-strand break(GO:0035861)
0.1 3.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 41.6 GO:0000139 Golgi membrane(GO:0000139)
0.1 2.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 15.8 GO:0034774 secretory granule lumen(GO:0034774)
0.0 0.3 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 2.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0031527 filopodium membrane(GO:0031527)
0.0 4.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.2 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 5.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 6.9 GO:0016607 nuclear speck(GO:0016607)
0.0 8.0 GO:0005813 centrosome(GO:0005813)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.0 4.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.7 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 23.7 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
5.7 80.4 GO:0032395 MHC class II receptor activity(GO:0032395)
5.7 45.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
5.6 50.3 GO:0031685 adenosine receptor binding(GO:0031685)
5.1 51.1 GO:0032027 myosin light chain binding(GO:0032027)
4.5 18.2 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
4.5 27.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
4.4 17.4 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
1.4 28.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.1 3.4 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.8 16.8 GO:0005522 profilin binding(GO:0005522)
0.8 17.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.8 2.4 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.8 3.0 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.7 3.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.7 2.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.7 8.5 GO:0046625 sphingolipid binding(GO:0046625)
0.6 9.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.6 3.0 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.6 4.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.5 1.6 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.5 20.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.5 7.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.5 1.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.5 5.5 GO:0051434 BH3 domain binding(GO:0051434)
0.4 2.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 1.3 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.4 6.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 1.3 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.3 18.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 3.1 GO:0005549 odorant binding(GO:0005549)
0.3 6.0 GO:0005542 folic acid binding(GO:0005542)
0.3 5.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 3.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 1.1 GO:0004487 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.3 8.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 5.6 GO:0035497 cAMP response element binding(GO:0035497)
0.3 0.8 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.3 1.6 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.3 6.4 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.2 2.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 5.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 5.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 2.6 GO:0050700 CARD domain binding(GO:0050700)
0.2 6.1 GO:0071837 HMG box domain binding(GO:0071837)
0.2 1.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 2.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 4.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 2.2 GO:0045159 myosin II binding(GO:0045159)
0.1 4.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 12.0 GO:0019843 rRNA binding(GO:0019843)
0.1 6.1 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.0 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 2.1 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.8 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 0.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 2.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.8 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.4 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 2.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 2.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 1.4 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.1 2.0 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 6.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 7.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.2 GO:0070402 NADPH binding(GO:0070402)
0.0 3.0 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 4.2 GO:0002039 p53 binding(GO:0002039)
0.0 23.3 GO:0003682 chromatin binding(GO:0003682)
0.0 2.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 3.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.4 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 4.1 GO:0003823 antigen binding(GO:0003823)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.4 GO:0016853 isomerase activity(GO:0016853)
0.0 0.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 59.4 PID S1P S1P3 PATHWAY S1P3 pathway
0.7 39.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.5 19.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 8.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.3 9.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 7.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 32.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 12.3 PID IL2 1PATHWAY IL2-mediated signaling events
0.2 2.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 4.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 2.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 7.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 2.7 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 3.0 PID IFNG PATHWAY IFN-gamma pathway
0.1 26.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 3.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.4 PID TNF PATHWAY TNF receptor signaling pathway
0.1 6.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 3.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 3.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 51.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
2.2 44.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.2 27.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.7 17.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.6 18.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.6 3.9 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.5 47.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 44.9 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.4 28.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 9.6 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2 5.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 16.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 8.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 2.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 5.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 2.6 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 3.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.0 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 3.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 0.9 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 2.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 4.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 3.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)