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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PBX3
Z-value: 5.48
Motif logo
Transcription factors associated with PBX3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PBX3
|
ENSG00000167081.18 | PBX3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX3 | hg38_v1_chr9_+_125748175_125748199, hg38_v1_chr9_+_125747345_125747380 | -0.29 | 9.8e-06 | Click! |
Activity profile of PBX3 motif
Sorted Z-values of PBX3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 17.1 | GO:1903892 | negative regulation of ATF6-mediated unfolded protein response(GO:1903892) |
| 4.4 | 21.8 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 4.2 | 12.6 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 4.0 | 35.9 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 3.9 | 11.8 | GO:0060221 | retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 3.3 | 13.3 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
| 3.1 | 40.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 3.1 | 64.8 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 3.0 | 14.8 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 2.6 | 18.4 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 2.6 | 12.9 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 2.3 | 25.2 | GO:0010529 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) |
| 2.2 | 19.8 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 2.1 | 10.6 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 2.0 | 6.1 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) |
| 2.0 | 10.1 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 2.0 | 6.0 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 2.0 | 17.7 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 2.0 | 5.9 | GO:0061027 | umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027) |
| 1.9 | 13.5 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 1.8 | 27.4 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 1.8 | 8.9 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 1.7 | 5.2 | GO:0022012 | subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875) |
| 1.7 | 6.9 | GO:0034445 | regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) |
| 1.7 | 5.2 | GO:0072023 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 1.6 | 8.2 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) histone H2A phosphorylation(GO:1990164) |
| 1.6 | 4.9 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 1.5 | 9.2 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.5 | 7.3 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 1.4 | 33.1 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 1.4 | 9.7 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 1.4 | 8.3 | GO:0016926 | protein desumoylation(GO:0016926) |
| 1.3 | 4.0 | GO:0018963 | phthalate metabolic process(GO:0018963) cellular response to luteinizing hormone stimulus(GO:0071373) |
| 1.3 | 3.9 | GO:1902617 | response to fluoride(GO:1902617) |
| 1.3 | 8.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.2 | 3.7 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 1.2 | 3.5 | GO:0021592 | fourth ventricle development(GO:0021592) third ventricle development(GO:0021678) |
| 1.2 | 5.8 | GO:0048104 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) |
| 1.1 | 16.3 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 1.1 | 2.2 | GO:0060369 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) |
| 1.1 | 1.1 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
| 1.1 | 3.2 | GO:2000053 | regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) |
| 1.0 | 10.4 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 1.0 | 2.0 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 1.0 | 25.2 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 1.0 | 4.0 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 1.0 | 9.9 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 1.0 | 10.5 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 1.0 | 6.7 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.9 | 25.6 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.9 | 38.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.8 | 9.3 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.8 | 3.3 | GO:1990737 | response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.8 | 4.9 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.8 | 2.4 | GO:0031446 | regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) relaxation of skeletal muscle(GO:0090076) |
| 0.8 | 8.9 | GO:0051344 | protein maturation by protein folding(GO:0022417) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
| 0.8 | 10.3 | GO:0043320 | natural killer cell degranulation(GO:0043320) |
| 0.8 | 49.8 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.8 | 2.3 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.7 | 9.6 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.7 | 22.6 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.7 | 32.4 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.7 | 2.1 | GO:0031587 | regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585) positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) |
| 0.7 | 2.7 | GO:0036414 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.7 | 21.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.7 | 6.0 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.6 | 8.3 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.6 | 4.9 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.6 | 1.8 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.6 | 4.6 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.6 | 1.1 | GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) |
| 0.6 | 2.3 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.6 | 2.2 | GO:0042377 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
| 0.5 | 2.7 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.5 | 3.8 | GO:0006489 | dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465) |
| 0.5 | 8.1 | GO:0048243 | norepinephrine secretion(GO:0048243) |
| 0.5 | 2.2 | GO:0036378 | calcitriol biosynthetic process from calciol(GO:0036378) |
| 0.5 | 30.5 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.5 | 3.6 | GO:0060492 | foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) |
| 0.5 | 5.5 | GO:0046838 | phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) |
| 0.5 | 1.9 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.5 | 4.3 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
| 0.5 | 1.4 | GO:1903719 | regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) |
| 0.4 | 4.0 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.4 | 3.6 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.4 | 5.3 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.4 | 8.8 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.4 | 4.0 | GO:1902572 | negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572) |
| 0.4 | 1.7 | GO:0014894 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.4 | 3.0 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.4 | 1.3 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.4 | 1.7 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.4 | 37.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.4 | 1.5 | GO:0019086 | late viral transcription(GO:0019086) |
| 0.4 | 10.3 | GO:0034776 | response to histamine(GO:0034776) cellular response to histamine(GO:0071420) |
| 0.4 | 6.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 2.9 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.4 | 11.3 | GO:1903846 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.4 | 2.2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.4 | 6.5 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.4 | 6.4 | GO:0002323 | natural killer cell activation involved in immune response(GO:0002323) |
| 0.4 | 3.2 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.3 | 1.4 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.3 | 3.7 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.3 | 3.7 | GO:0007512 | adult heart development(GO:0007512) |
| 0.3 | 15.0 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.3 | 4.6 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.3 | 8.5 | GO:0061154 | endothelial tube morphogenesis(GO:0061154) |
| 0.3 | 3.9 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.3 | 20.3 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.3 | 0.6 | GO:1902866 | regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866) |
| 0.3 | 3.3 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.3 | 12.8 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.3 | 4.3 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.3 | 6.5 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.3 | 26.1 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.3 | 2.8 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.3 | 2.8 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.3 | 6.2 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.3 | 5.2 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.3 | 2.4 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.3 | 3.6 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.3 | 1.5 | GO:0006050 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
| 0.3 | 3.3 | GO:0090312 | positive regulation of protein deacetylation(GO:0090312) |
| 0.3 | 0.8 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.3 | 4.3 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.2 | 13.9 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.2 | 0.7 | GO:2000523 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.2 | 2.6 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.2 | 4.9 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.2 | 1.2 | GO:0021764 | amygdala development(GO:0021764) |
| 0.2 | 1.6 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.2 | 7.1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration(GO:0043536) |
| 0.2 | 28.1 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 0.2 | 5.2 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.2 | 3.5 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.2 | 8.7 | GO:0016239 | positive regulation of macroautophagy(GO:0016239) |
| 0.2 | 0.2 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.2 | 0.4 | GO:0009078 | alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) |
| 0.2 | 9.3 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.2 | 4.7 | GO:0007530 | sex determination(GO:0007530) |
| 0.2 | 1.4 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.2 | 5.6 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.2 | 0.9 | GO:0097070 | ductus arteriosus closure(GO:0097070) |
| 0.2 | 2.3 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 6.9 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.1 | 4.5 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.1 | 2.7 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.1 | 9.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.1 | 2.3 | GO:2000178 | negative regulation of neural precursor cell proliferation(GO:2000178) |
| 0.1 | 6.1 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.1 | 0.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 4.5 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 2.1 | GO:0006768 | biotin metabolic process(GO:0006768) |
| 0.1 | 3.6 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.1 | 2.1 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.1 | 2.7 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
| 0.1 | 0.5 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) positive regulation of chondrocyte proliferation(GO:1902732) |
| 0.1 | 1.5 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
| 0.1 | 19.5 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.1 | 4.7 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.1 | 3.3 | GO:0042472 | inner ear morphogenesis(GO:0042472) |
| 0.1 | 3.5 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 1.2 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 14.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.9 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.1 | 1.3 | GO:0043931 | ossification involved in bone maturation(GO:0043931) |
| 0.1 | 1.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 4.2 | GO:0032330 | regulation of chondrocyte differentiation(GO:0032330) |
| 0.1 | 2.6 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.1 | 2.1 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 0.1 | 1.8 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.1 | 0.9 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 0.7 | GO:0072178 | nephric duct development(GO:0072176) nephric duct morphogenesis(GO:0072178) |
| 0.1 | 0.4 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 9.7 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 18.4 | GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091) |
| 0.1 | 2.8 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 1.3 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 3.8 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.1 | 0.7 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 0.1 | 2.9 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.1 | 0.6 | GO:2001053 | regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.1 | 4.5 | GO:0006835 | dicarboxylic acid transport(GO:0006835) |
| 0.1 | 0.6 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.1 | 0.5 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936) |
| 0.1 | 0.4 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 8.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.1 | 2.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 3.6 | GO:0046323 | glucose import(GO:0046323) |
| 0.1 | 2.2 | GO:0030317 | sperm motility(GO:0030317) |
| 0.1 | 44.4 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.1 | 1.0 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 6.6 | GO:0007411 | axon guidance(GO:0007411) |
| 0.0 | 3.8 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
| 0.0 | 4.4 | GO:0006415 | translational termination(GO:0006415) |
| 0.0 | 5.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 2.0 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) defense response to Gram-positive bacterium(GO:0050830) |
| 0.0 | 0.5 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 3.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 1.8 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 4.7 | GO:0051262 | protein tetramerization(GO:0051262) |
| 0.0 | 2.9 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 2.4 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 6.4 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.0 | 0.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 2.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 3.2 | GO:0006661 | phosphatidylinositol biosynthetic process(GO:0006661) |
| 0.0 | 4.5 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 5.0 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.0 | 1.2 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.3 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 0.0 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 29.8 | GO:0070695 | FHF complex(GO:0070695) |
| 7.3 | 21.8 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 5.1 | 35.9 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 4.0 | 32.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 3.1 | 40.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 2.7 | 13.5 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 2.6 | 10.4 | GO:0002139 | stereocilia coupling link(GO:0002139) |
| 2.6 | 10.3 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 2.6 | 7.7 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 2.3 | 25.0 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 1.7 | 6.9 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 1.5 | 8.9 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 1.5 | 5.8 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 1.4 | 22.6 | GO:0033177 | proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 1.3 | 1.3 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 1.1 | 15.9 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.9 | 16.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.8 | 6.6 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.8 | 8.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.7 | 2.1 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.6 | 3.2 | GO:0035838 | growing cell tip(GO:0035838) |
| 0.6 | 7.3 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.5 | 10.8 | GO:0010369 | chromocenter(GO:0010369) |
| 0.5 | 2.6 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.5 | 2.6 | GO:0044308 | axonal spine(GO:0044308) |
| 0.5 | 8.5 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.5 | 9.7 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.5 | 3.3 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.5 | 1.4 | GO:1990597 | AIP1-IRE1 complex(GO:1990597) |
| 0.4 | 4.0 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.4 | 8.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.4 | 125.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.4 | 4.4 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.4 | 18.6 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.4 | 7.1 | GO:0031045 | dense core granule(GO:0031045) |
| 0.3 | 7.7 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.3 | 4.0 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.3 | 1.5 | GO:1990425 | junctional membrane complex(GO:0030314) ryanodine receptor complex(GO:1990425) |
| 0.3 | 1.4 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.3 | 9.8 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.3 | 2.6 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.3 | 20.1 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.3 | 10.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.2 | 14.0 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.2 | 28.1 | GO:0016234 | inclusion body(GO:0016234) |
| 0.2 | 7.2 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.2 | 1.7 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.2 | 25.8 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 13.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.2 | 2.5 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.2 | 29.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 4.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 0.9 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.2 | 4.2 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.2 | 4.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.2 | 13.8 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.2 | 2.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 3.6 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.1 | 2.9 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 3.7 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 11.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 2.4 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 27.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 1.5 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.1 | 3.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 3.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 1.1 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 5.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 1.5 | GO:0030904 | retromer complex(GO:0030904) |
| 0.1 | 3.8 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 7.0 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.1 | 2.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 2.6 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 0.9 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 4.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 6.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 2.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.4 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 4.6 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 0.2 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 2.4 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 1.9 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 0.4 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 30.2 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 5.4 | 64.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 4.4 | 21.8 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 3.2 | 12.9 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 3.0 | 45.6 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 3.0 | 11.8 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 2.8 | 35.9 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239) |
| 2.1 | 27.4 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 1.9 | 13.5 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 1.9 | 13.5 | GO:0000182 | rDNA binding(GO:0000182) |
| 1.8 | 9.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 1.7 | 8.7 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 1.5 | 4.6 | GO:0005135 | erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135) |
| 1.5 | 4.5 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 1.5 | 5.9 | GO:0035939 | microsatellite binding(GO:0035939) |
| 1.4 | 4.3 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 1.4 | 8.3 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 1.4 | 12.3 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 1.3 | 6.7 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 1.3 | 5.2 | GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) |
| 1.2 | 4.9 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 1.1 | 18.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 1.1 | 12.6 | GO:0031433 | telethonin binding(GO:0031433) |
| 1.1 | 3.2 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
| 1.1 | 3.2 | GO:0042806 | fucose binding(GO:0042806) |
| 1.0 | 16.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.9 | 22.6 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.8 | 9.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.8 | 9.3 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.8 | 10.1 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.8 | 26.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.8 | 3.1 | GO:0047708 | biotinidase activity(GO:0047708) |
| 0.7 | 9.7 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.7 | 7.3 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.7 | 2.2 | GO:0070643 | vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643) |
| 0.7 | 3.6 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
| 0.7 | 3.6 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.7 | 2.8 | GO:0004513 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
| 0.7 | 9.6 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.7 | 2.7 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.7 | 3.3 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.7 | 2.0 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.6 | 5.8 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.6 | 8.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.6 | 35.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.6 | 5.6 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.6 | 5.5 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) |
| 0.5 | 7.1 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.5 | 45.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.5 | 5.6 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.5 | 3.8 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.5 | 3.7 | GO:0071253 | connexin binding(GO:0071253) |
| 0.5 | 1.4 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.5 | 16.8 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.4 | 6.4 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.4 | 37.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 5.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.4 | 8.5 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.4 | 90.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 7.7 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.4 | 8.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.4 | 4.7 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.4 | 4.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.4 | 1.8 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.3 | 2.7 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.3 | 7.3 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.3 | 21.9 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.3 | 10.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.3 | 8.2 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.3 | 40.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.3 | 3.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.3 | 25.1 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.3 | 6.9 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.3 | 10.1 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.2 | 7.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 0.9 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.2 | 3.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 3.9 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.2 | 4.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 5.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 4.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.2 | 5.6 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.2 | 3.6 | GO:0047617 | very long-chain fatty acid-CoA ligase activity(GO:0031957) acyl-CoA hydrolase activity(GO:0047617) |
| 0.2 | 4.6 | GO:0042171 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
| 0.2 | 8.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.2 | 2.1 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.2 | 2.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.2 | 4.5 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.2 | 1.4 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.2 | 19.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.2 | 1.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.2 | 2.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 6.9 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 27.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 1.9 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 2.6 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 35.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 9.4 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 2.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 1.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.4 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 2.5 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.1 | 6.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 4.3 | GO:0008066 | glutamate receptor activity(GO:0008066) |
| 0.1 | 24.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 1.6 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 1.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 6.9 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.1 | 2.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 1.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 3.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 8.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 9.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 11.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 3.0 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 1.5 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 0.4 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 7.7 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 319.8 | GO:0046872 | metal ion binding(GO:0046872) |
| 0.1 | 71.0 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 2.9 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.1 | 5.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 10.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 3.9 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.9 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.9 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 12.4 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 3.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.5 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.0 | 3.0 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.7 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 2.5 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 1.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.3 | GO:0038191 | neuropilin binding(GO:0038191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 24.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.8 | 40.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.8 | 12.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.7 | 36.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.5 | 15.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.5 | 13.1 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.4 | 11.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.4 | 36.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.3 | 3.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 4.9 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.3 | 3.7 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.3 | 20.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 7.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.3 | 17.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.3 | 19.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 4.6 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.2 | 8.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 17.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 5.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 5.2 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 3.6 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 10.8 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 3.2 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 5.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 6.4 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 4.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 21.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 1.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 2.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 21.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.5 | 40.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.2 | 31.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.1 | 25.2 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.8 | 42.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.6 | 7.1 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.5 | 242.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 16.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.5 | 25.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 12.9 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.5 | 27.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.5 | 10.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.4 | 28.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 5.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.4 | 7.7 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.4 | 14.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 15.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 5.2 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.3 | 4.9 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.3 | 4.5 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.3 | 17.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 10.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 4.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.2 | 9.7 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.2 | 8.5 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.2 | 3.8 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.2 | 4.0 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.2 | 2.3 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.2 | 4.3 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 7.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 3.7 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.2 | 5.3 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 6.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 2.6 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 2.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 2.3 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 3.2 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 5.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 3.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 4.2 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 0.9 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 11.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.7 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 3.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.8 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 2.7 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.1 | 2.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 1.8 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 0.9 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 5.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 4.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 2.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 2.2 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 2.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 3.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 2.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 2.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 3.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.9 | REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | Genes involved in NCAM signaling for neurite out-growth |