Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PGR
Z-value: 5.47
Motif logo
Transcription factors associated with PGR
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PGR
|
ENSG00000082175.15 | PGR |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PGR | hg38_v1_chr11_-_101129806_101129822 | 0.25 | 1.4e-04 | Click! |
Activity profile of PGR motif
Sorted Z-values of PGR motif
Network of associatons between targets according to the STRING database.
First level regulatory network of PGR
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 17.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 2.9 | 8.7 | GO:0002445 | type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) |
| 2.2 | 6.6 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 1.9 | 7.5 | GO:0019072 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 1.6 | 4.8 | GO:1905154 | negative regulation of synaptic vesicle recycling(GO:1903422) negative regulation of membrane invagination(GO:1905154) |
| 1.2 | 4.9 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 1.2 | 4.7 | GO:1903611 | regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634) |
| 1.2 | 19.6 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 1.1 | 3.3 | GO:0090298 | positive regulation of fat cell proliferation(GO:0070346) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) |
| 1.1 | 3.2 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 1.0 | 2.1 | GO:0001810 | regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068) |
| 1.0 | 5.9 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.9 | 2.6 | GO:0060018 | astrocyte fate commitment(GO:0060018) |
| 0.9 | 4.3 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.8 | 2.5 | GO:0019075 | virus maturation(GO:0019075) |
| 0.8 | 3.3 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.8 | 10.8 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.8 | 2.4 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.8 | 6.5 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.7 | 39.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.7 | 2.1 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.7 | 1.4 | GO:0033025 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
| 0.7 | 3.3 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.6 | 6.9 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.6 | 4.2 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.6 | 1.7 | GO:1990641 | negative regulation of intestinal absorption(GO:1904479) response to iron ion starvation(GO:1990641) |
| 0.6 | 10.1 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.5 | 3.3 | GO:2000470 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 0.5 | 0.5 | GO:0060448 | dichotomous subdivision of terminal units involved in lung branching(GO:0060448) |
| 0.5 | 9.2 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.5 | 2.2 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.5 | 1.6 | GO:0021571 | rhombomere 5 development(GO:0021571) |
| 0.5 | 4.2 | GO:0015705 | iodide transport(GO:0015705) |
| 0.5 | 1.5 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.5 | 5.6 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.5 | 2.5 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.5 | 1.5 | GO:0048769 | skeletal muscle myosin thick filament assembly(GO:0030241) sarcomerogenesis(GO:0048769) |
| 0.5 | 1.5 | GO:1903033 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.5 | 1.8 | GO:0002370 | natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) |
| 0.4 | 2.7 | GO:0060915 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915) |
| 0.4 | 3.6 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.4 | 5.3 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.4 | 4.3 | GO:0034086 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
| 0.4 | 1.7 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.4 | 1.3 | GO:0071810 | regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009) |
| 0.4 | 1.2 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.4 | 5.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.4 | 5.6 | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) |
| 0.4 | 1.2 | GO:0090675 | intermicrovillar adhesion(GO:0090675) |
| 0.4 | 6.5 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.4 | 5.6 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.3 | 1.7 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.3 | 1.0 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.3 | 1.0 | GO:0018963 | phthalate metabolic process(GO:0018963) |
| 0.3 | 3.5 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.3 | 9.4 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.3 | 3.4 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.3 | 3.1 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.3 | 4.9 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.3 | 8.0 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.3 | 1.4 | GO:0038163 | thrombopoietin-mediated signaling pathway(GO:0038163) |
| 0.3 | 2.5 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.3 | 2.5 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.3 | 3.4 | GO:0060068 | vagina development(GO:0060068) |
| 0.3 | 1.0 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.2 | 1.2 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.2 | 1.2 | GO:1904499 | glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793) |
| 0.2 | 1.9 | GO:0003402 | planar cell polarity pathway involved in axis elongation(GO:0003402) |
| 0.2 | 2.8 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.2 | 7.5 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.2 | 1.9 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.2 | 1.2 | GO:0015842 | aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) |
| 0.2 | 7.9 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.2 | 2.4 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.2 | 2.8 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.2 | 1.9 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
| 0.2 | 7.3 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 2.1 | GO:0009744 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
| 0.2 | 1.8 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.2 | 3.8 | GO:0003094 | glomerular filtration(GO:0003094) |
| 0.2 | 1.9 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.2 | 4.0 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.2 | 0.7 | GO:0034445 | regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) |
| 0.2 | 9.1 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.2 | 1.9 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
| 0.2 | 0.6 | GO:0002774 | Fc receptor mediated inhibitory signaling pathway(GO:0002774) |
| 0.2 | 3.7 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.2 | 0.8 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.2 | 0.3 | GO:1902285 | sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) |
| 0.2 | 8.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 1.0 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 0.1 | 1.3 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.1 | 1.6 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 2.0 | GO:0051573 | negative regulation of histone H3-K9 methylation(GO:0051573) |
| 0.1 | 0.7 | GO:0035624 | receptor transactivation(GO:0035624) |
| 0.1 | 0.6 | GO:1904450 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
| 0.1 | 0.6 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.1 | 2.6 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) |
| 0.1 | 1.6 | GO:0001865 | NK T cell differentiation(GO:0001865) |
| 0.1 | 1.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 0.2 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.1 | 1.1 | GO:0015868 | purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868) |
| 0.1 | 2.2 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) |
| 0.1 | 0.7 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 2.3 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.1 | 4.2 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 3.4 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 0.7 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.1 | 2.8 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.1 | 2.5 | GO:0032648 | regulation of interferon-beta production(GO:0032648) |
| 0.1 | 1.9 | GO:0048535 | lymph node development(GO:0048535) |
| 0.1 | 0.2 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) |
| 0.1 | 2.1 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.1 | 1.5 | GO:0046512 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 0.1 | 53.8 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.1 | 1.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 2.2 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 2.5 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.1 | 2.0 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 1.3 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.1 | 6.3 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.1 | 0.5 | GO:0019441 | tryptophan catabolic process to kynurenine(GO:0019441) |
| 0.1 | 1.0 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
| 0.1 | 4.6 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.1 | 0.9 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.1 | 0.6 | GO:1904354 | negative regulation of telomere capping(GO:1904354) |
| 0.1 | 1.2 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
| 0.1 | 2.8 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.1 | 2.6 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.1 | 1.0 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 9.3 | GO:2000257 | regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257) |
| 0.1 | 2.6 | GO:0007616 | long-term memory(GO:0007616) |
| 0.1 | 1.9 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 0.7 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
| 0.1 | 2.4 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.1 | 0.9 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 2.4 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.1 | 0.4 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 0.1 | 0.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 8.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.5 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.1 | 2.7 | GO:0032570 | response to progesterone(GO:0032570) |
| 0.1 | 2.4 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.1 | 0.5 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.1 | 0.2 | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.1 | 4.6 | GO:0030516 | regulation of axon extension(GO:0030516) |
| 0.1 | 0.6 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.1 | 1.2 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 1.0 | GO:0002003 | angiotensin maturation(GO:0002003) |
| 0.0 | 0.4 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.0 | 1.1 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
| 0.0 | 1.2 | GO:0042136 | neurotransmitter biosynthetic process(GO:0042136) |
| 0.0 | 0.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.3 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.0 | 1.7 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.0 | 4.8 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.0 | 1.3 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 1.5 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.0 | 0.8 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.0 | 0.1 | GO:0001519 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 0.0 | 1.3 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 1.6 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.0 | 1.6 | GO:0009798 | axis specification(GO:0009798) |
| 0.0 | 1.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 1.0 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 1.2 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.0 | 1.2 | GO:0002687 | positive regulation of leukocyte migration(GO:0002687) |
| 0.0 | 0.7 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 0.3 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 0.6 | GO:0042116 | macrophage activation(GO:0042116) |
| 0.0 | 1.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.4 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.7 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.0 | 0.9 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 0.7 | GO:0086010 | membrane depolarization during action potential(GO:0086010) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 17.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 3.1 | 9.2 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 1.4 | 4.3 | GO:0032116 | SMC loading complex(GO:0032116) |
| 1.2 | 4.9 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.8 | 2.5 | GO:0071756 | dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752) IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756) |
| 0.8 | 4.8 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.8 | 6.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.7 | 2.2 | GO:0098536 | deuterosome(GO:0098536) |
| 0.7 | 8.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 1.6 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.4 | 2.6 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.4 | 2.5 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.4 | 2.1 | GO:0031501 | mannosyltransferase complex(GO:0031501) |
| 0.3 | 3.4 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.3 | 0.7 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.3 | 5.9 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.3 | 2.5 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.3 | 3.1 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.3 | 1.9 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.3 | 1.3 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.2 | 3.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.2 | 1.2 | GO:0070083 | clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083) |
| 0.2 | 2.9 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 0.6 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.2 | 1.9 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.2 | 1.7 | GO:0045179 | apical cortex(GO:0045179) |
| 0.2 | 2.0 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.2 | 1.2 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.2 | 1.2 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.2 | 6.8 | GO:0043218 | compact myelin(GO:0043218) |
| 0.2 | 69.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 0.7 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.1 | 1.7 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 4.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.6 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 0.1 | 5.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 1.2 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 2.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 1.0 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 26.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 9.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 2.4 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.1 | 1.4 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.1 | 1.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 0.7 | GO:1990745 | EARP complex(GO:1990745) |
| 0.1 | 1.3 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 5.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 1.8 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 1.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 1.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 1.8 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 1.3 | GO:0031082 | BLOC complex(GO:0031082) |
| 0.1 | 4.8 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 7.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 1.0 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 1.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 1.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 1.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 1.2 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 1.1 | GO:0030128 | clathrin coat of endocytic vesicle(GO:0030128) |
| 0.0 | 7.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.7 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.0 | 0.6 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.3 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 3.6 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 3.4 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.5 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 1.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.6 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 9.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 4.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 3.3 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 4.5 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 5.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.2 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 1.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 2.0 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 17.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.7 | 5.2 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 1.2 | 3.7 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 1.2 | 4.7 | GO:0004341 | gluconolactonase activity(GO:0004341) |
| 0.9 | 2.6 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.8 | 4.0 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.8 | 5.6 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.7 | 2.2 | GO:0086059 | voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059) |
| 0.7 | 5.9 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.7 | 10.8 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.7 | 2.1 | GO:0004584 | dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584) |
| 0.7 | 4.2 | GO:0070004 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.7 | 59.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.6 | 7.5 | GO:0004075 | biotin carboxylase activity(GO:0004075) |
| 0.6 | 4.9 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.6 | 6.5 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.6 | 1.7 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.5 | 3.3 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.5 | 4.9 | GO:0046935 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.5 | 2.1 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
| 0.5 | 1.6 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.5 | 2.5 | GO:0019862 | IgA binding(GO:0019862) |
| 0.5 | 8.6 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.5 | 1.4 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.5 | 1.4 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.4 | 9.8 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.4 | 3.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.3 | 9.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.3 | 3.1 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.3 | 1.0 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.3 | 1.3 | GO:0004102 | choline O-acetyltransferase activity(GO:0004102) |
| 0.3 | 9.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 1.0 | GO:0003865 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751) |
| 0.3 | 2.4 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.3 | 1.2 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.3 | 10.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.3 | 1.2 | GO:0015222 | serotonin transmembrane transporter activity(GO:0015222) |
| 0.3 | 1.7 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.3 | 2.7 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.3 | 7.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.3 | 1.6 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
| 0.2 | 5.0 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.2 | 1.5 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.2 | 2.4 | GO:0004568 | chitinase activity(GO:0004568) chitin binding(GO:0008061) |
| 0.2 | 1.9 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.2 | 1.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 6.8 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.2 | 2.5 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.2 | 2.7 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 42.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 4.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 0.9 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.2 | 0.9 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 0.5 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.2 | 1.9 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.2 | 1.4 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.1 | 12.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.6 | GO:0047298 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
| 0.1 | 0.7 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 3.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 1.5 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.1 | 1.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 2.4 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 4.1 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 1.5 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 7.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 2.8 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 2.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.1 | 9.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.2 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.1 | 0.6 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.1 | 0.6 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.5 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 2.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.3 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.1 | 0.8 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.1 | 1.0 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 1.2 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 2.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 20.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 1.0 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 1.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 3.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 6.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 2.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 1.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 1.4 | GO:0002162 | dystroglycan binding(GO:0002162) nitric-oxide synthase binding(GO:0050998) |
| 0.1 | 3.5 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.1 | 6.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 6.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 2.2 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 2.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 3.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 1.5 | GO:0042166 | acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166) |
| 0.0 | 2.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.2 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.0 | 0.8 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 1.0 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 3.1 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.1 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.0 | 4.5 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 3.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.7 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 4.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 1.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 1.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 1.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.3 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.0 | 1.0 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.1 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.0 | 0.6 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 1.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 2.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.7 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 1.6 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 3.1 | GO:0005516 | calmodulin binding(GO:0005516) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 9.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.3 | 74.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 1.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 2.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 8.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 7.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 5.4 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 2.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 1.6 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 3.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 3.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 1.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 7.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 3.4 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 4.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 2.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 2.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 2.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 2.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.9 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 4.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.6 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.8 | 17.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 8.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.5 | 8.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.3 | 7.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.3 | 14.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 4.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.3 | 7.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 2.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 4.9 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 3.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 1.3 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.2 | 14.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 2.7 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.2 | 9.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 9.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 1.9 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 5.5 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.1 | 3.6 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 4.7 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 2.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.7 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.1 | 5.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 7.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.1 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 2.1 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 2.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 2.8 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 0.5 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.5 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 5.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 3.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.9 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 1.4 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 1.1 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 2.0 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 10.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 2.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.6 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 2.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.7 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.0 | 0.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 3.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 2.5 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 0.5 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.0 | 2.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.0 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |