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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PITX1

Z-value: 8.31

Motif logo

Transcription factors associated with PITX1

Gene Symbol Gene ID Gene Info
ENSG00000069011.16 PITX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX1hg38_v1_chr5_-_135034212_135034294-0.009.9e-01Click!

Activity profile of PITX1 motif

Sorted Z-values of PITX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr19_+_49676140 75.00 ENST00000527382.5
ENST00000528623.5
protein arginine methyltransferase 1
chr12_+_53442555 47.29 ENST00000549135.1
proline rich 13
chr8_-_100706763 46.79 ENST00000517990.5
poly(A) binding protein cytoplasmic 1
chr2_-_61500568 46.26 ENST00000677476.1
exportin 1
chr20_+_57351218 45.49 ENST00000371242.6
ENST00000527947.5
ENST00000395841.7
ribonucleic acid export 1
chr1_-_8878018 43.43 ENST00000646660.1
ENST00000646906.1
enolase 1
chr1_+_203861575 39.61 ENST00000414487.7
small nuclear ribonucleoprotein polypeptide E
chr3_-_64023986 39.18 ENST00000394431.6
proteasome 26S subunit, non-ATPase 6
chr19_+_1077394 36.99 ENST00000590577.2
Rho GTPase activating protein 45
chr14_+_73097027 35.22 ENST00000532192.1
RNA binding motif protein 25
chr19_+_48321454 35.04 ENST00000599704.5
epithelial membrane protein 3
chr3_+_127598400 34.47 ENST00000265056.12
minichromosome maintenance complex component 2
chr19_+_58544045 34.03 ENST00000253024.10
ENST00000593582.5
tripartite motif containing 28
chr4_+_56977710 33.34 ENST00000450656.5
ENST00000381227.5
RNA polymerase II subunit B
chr5_-_181239571 33.25 ENST00000509535.5
receptor for activated C kinase 1
chr13_+_37000774 32.86 ENST00000389704.4
exosome component 8
chr19_+_41262480 32.72 ENST00000352456.7
ENST00000595018.5
ENST00000597725.5
heterogeneous nuclear ribonucleoprotein U like 1
chr3_+_37020333 32.42 ENST00000616768.5
mutL homolog 1
chr20_+_37179109 31.93 ENST00000373622.9
ribophorin II
chr7_+_99374240 31.69 ENST00000443222.6
ENST00000414376.5
actin related protein 2/3 complex subunit 1B
chr2_+_47695819 31.33 ENST00000652107.1
mutS homolog 6
chr20_+_58981208 31.28 ENST00000602795.6
ENST00000652272.2
negative elongation factor complex member C/D
chr22_-_42640601 30.52 ENST00000505920.1
ATP synthase membrane subunit g like
chr16_+_30075967 30.28 ENST00000279387.12
ENST00000562664.5
ENST00000627746.2
ENST00000562222.5
protein phosphatase 4 catalytic subunit
chr5_+_172958729 29.91 ENST00000519974.5
ENST00000521476.5
ribosomal protein L26 like 1
chr17_+_75234704 29.52 ENST00000579838.1
nucleoporin 85
chr22_-_41940208 29.35 ENST00000472374.6
centromere protein M
chr1_+_44746401 29.27 ENST00000372217.5
kinesin family member 2C
chr8_-_101206064 28.94 ENST00000518336.5
ENST00000520454.1
zinc finger protein 706
chr17_-_8210565 28.32 ENST00000577833.5
ENST00000585124.6
ENST00000534871.5
ENST00000583915.1
ENST00000316199.10
ENST00000581511.5
aurora kinase B
chr13_+_30427950 28.26 ENST00000436446.1
ubiquitin conjugating enzyme E2 L5
chr20_+_1113257 27.93 ENST00000333082.7
ENST00000381899.8
proteasome inhibitor subunit 1
chr7_+_55887277 27.11 ENST00000426595.1
novel zinc finger protein 713 (ZNF713) and mitochondrial ribosomal protein S17 (MRPS17) protein
chr11_+_35176611 27.10 ENST00000279452.10
CD44 molecule (Indian blood group)
chr14_+_35278618 26.58 ENST00000540871.5
proteasome 20S subunit alpha 6
chr7_+_55951852 26.22 ENST00000285298.9
mitochondrial ribosomal protein S17
chr12_-_56741535 26.09 ENST00000647707.1
novel protein
chr1_-_45542726 26.03 ENST00000676549.1
peroxiredoxin 1
chr11_+_35186820 25.95 ENST00000531110.6
ENST00000525685.6
CD44 molecule (Indian blood group)
chr5_+_74715503 25.45 ENST00000513336.5
hexosaminidase subunit beta
chr11_+_35176639 24.88 ENST00000527889.6
CD44 molecule (Indian blood group)
chr4_+_1974633 24.86 ENST00000677895.1
nuclear receptor binding SET domain protein 2
chr20_+_57351528 24.60 ENST00000395840.6
ribonucleic acid export 1
chr12_-_110445540 24.49 ENST00000547365.1
actin related protein 2/3 complex subunit 3
chr5_-_178187364 24.09 ENST00000463439.3
germ cell-less 2, spermatogenesis associated
chr2_-_196799642 23.26 ENST00000409364.3
ENST00000263956.8
general transcription factor IIIC subunit 3
chr16_+_67570741 23.26 ENST00000644753.1
ENST00000642819.1
ENST00000645306.1
CCCTC-binding factor
chr11_+_108116688 22.34 ENST00000672284.1
acetyl-CoA acetyltransferase 1
chr5_+_172959416 22.30 ENST00000265100.6
ENST00000519239.5
ribosomal protein L26 like 1
chr19_+_17511606 22.02 ENST00000252603.7
ENST00000600923.5
6-phosphogluconolactonase
chr20_+_380747 21.95 ENST00000217233.9
tribbles pseudokinase 3
chr7_-_5959083 21.92 ENST00000539903.5
radial spoke head 10 homolog B
chr6_-_31540536 21.61 ENST00000376177.6
DExD-box helicase 39B
chr7_-_100101915 21.57 ENST00000621318.4
ENST00000343023.10
minichromosome maintenance complex component 7
chr16_-_18790321 21.28 ENST00000322989.8
ENST00000563390.5
ribosomal protein S15a
chr15_+_41286011 21.20 ENST00000661438.1
novel protein
chr17_+_43006740 20.67 ENST00000438323.2
ENST00000415816.7
interferon induced protein 35
chr2_+_233195433 20.40 ENST00000417661.1
inositol polyphosphate-5-phosphatase D
chr20_+_45890236 20.38 ENST00000372484.8
ENST00000677394.1
cathepsin A
chr1_-_244860376 20.21 ENST00000638716.1
heterogeneous nuclear ribonucleoprotein U
chr2_+_38778194 19.94 ENST00000409566.1
ENST00000281950.8
gem nuclear organelle associated protein 6
chr19_-_39335999 19.93 ENST00000602185.5
ENST00000598034.5
ENST00000601387.5
ENST00000595636.1
ENST00000253054.12
ENST00000594700.5
ENST00000597595.6
glia maturation factor gamma
chr5_+_32531786 19.85 ENST00000512913.5
SUB1 regulator of transcription
chr1_-_39883434 19.68 ENST00000541099.5
ENST00000441669.6
ENST00000316891.10
ENST00000537440.5
ENST00000372818.5
tRNA isopentenyltransferase 1
chr12_-_31792290 19.66 ENST00000340398.5
H3.5 histone
chr14_+_54396949 19.65 ENST00000611205.4
cyclin dependent kinase inhibitor 3
chr14_+_54396964 19.48 ENST00000543789.6
ENST00000442975.6
ENST00000458126.6
ENST00000556102.6
ENST00000335183.11
cyclin dependent kinase inhibitor 3
chr1_+_27830761 19.43 ENST00000311772.10
ENST00000236412.11
ENST00000373931.8
protein phosphatase 1 regulatory subunit 8
chr3_-_64019334 19.43 ENST00000480205.5
proteasome 26S subunit, non-ATPase 6
chr3_-_32502783 19.42 ENST00000205636.4
CKLF like MARVEL transmembrane domain containing 6
chr3_-_10321041 19.20 ENST00000397109.7
ENST00000428626.5
ENST00000445064.1
ENST00000431352.1
ENST00000397117.5
ENST00000337354.8
ENST00000383801.6
ENST00000432213.1
ENST00000350697.8
SEC13 homolog, nuclear pore and COPII coat complex component
chr19_+_22286433 19.19 ENST00000601693.2
zinc finger protein 729
chr7_+_74453790 19.11 ENST00000265755.7
ENST00000424337.7
ENST00000455841.6
GTF2I repeat domain containing 1
chr12_-_54295748 19.07 ENST00000540264.2
ENST00000312156.8
nuclear factor, erythroid 2
chr19_-_22784091 19.06 ENST00000596209.4
zinc finger protein 99
chr17_+_59197553 19.03 ENST00000582004.1
ENST00000577660.1
proline rich 11
novel protein
chr19_+_10991175 18.81 ENST00000644065.1
ENST00000644963.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr5_+_74685225 18.80 ENST00000261416.12
hexosaminidase subunit beta
chr22_+_24555981 18.72 ENST00000215829.8
ENST00000402849.5
small nuclear ribonucleoprotein D3 polypeptide
chrX_+_41339931 18.72 ENST00000642424.1
DEAD-box helicase 3 X-linked
chr5_+_43120883 18.70 ENST00000515326.5
ENST00000682664.1
zinc finger protein 131
chr15_+_63529142 18.51 ENST00000268049.11
ubiquitin specific peptidase 3
chr1_-_154608705 18.51 ENST00000649749.1
ENST00000648871.1
adenosine deaminase RNA specific
chr8_+_26291494 18.49 ENST00000380737.8
ENST00000524169.5
protein phosphatase 2 regulatory subunit Balpha
chr22_+_40346508 18.42 ENST00000636714.1
ENST00000216194.11
ENST00000623978.3
ENST00000636265.1
ENST00000680378.1
adenylosuccinate lyase
chr17_-_41982321 18.29 ENST00000587727.6
DnaJ heat shock protein family (Hsp40) member C7
chr7_+_74209386 17.94 ENST00000344995.9
linker for activation of T cells family member 2
chr2_+_74206384 17.92 ENST00000678623.1
ENST00000678731.1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr17_+_68249200 17.87 ENST00000577985.5
archaelysin family metallopeptidase 2
chrX_+_23664251 17.69 ENST00000379349.5
peroxiredoxin 4
chr1_-_11055820 17.64 ENST00000490101.1
spermidine synthase
chr13_+_97960192 17.49 ENST00000496368.6
ENST00000421861.7
ENST00000357602.7
importin 5
chr11_+_62761536 17.48 ENST00000533442.5
RNA polymerase II subunit G
chr16_-_8936633 17.43 ENST00000381886.8
ubiquitin specific peptidase 7
chr8_+_54135203 17.39 ENST00000260102.9
ENST00000519831.5
mitochondrial ribosomal protein L15
chr8_-_144426982 17.19 ENST00000526054.5
ENST00000529182.5
VPS28 subunit of ESCRT-I
chr19_+_54105923 17.05 ENST00000420296.1
NADH:ubiquinone oxidoreductase subunit A3
chr19_+_48325323 17.01 ENST00000596315.5
epithelial membrane protein 3
chr16_+_30200729 17.01 ENST00000563322.5
sulfotransferase family 1A member 3
chrX_-_23743201 16.89 ENST00000492081.1
ENST00000379303.10
ENST00000336430.11
acyl-CoA thioesterase 9
chr20_+_37179310 16.86 ENST00000373632.8
ENST00000237530.11
ribophorin II
chr3_+_42590838 16.78 ENST00000011691.6
SS18 like 2
chr11_+_17295322 16.76 ENST00000458064.6
ENST00000622082.4
nucleobindin 2
chr11_+_35176696 16.70 ENST00000528455.5
CD44 molecule (Indian blood group)
chr16_-_2264221 16.66 ENST00000566397.5
RNA binding protein with serine rich domain 1
chr19_+_18559000 16.60 ENST00000602094.5
KxDL motif containing 1
chr1_-_152036984 16.55 ENST00000271638.3
S100 calcium binding protein A11
chr12_-_54297884 16.35 ENST00000553198.1
nuclear factor, erythroid 2
chr19_-_3547306 16.10 ENST00000589063.5
ENST00000615073.4
major facilitator superfamily domain containing 12
chr19_+_52429181 15.94 ENST00000301085.8
zinc finger protein 534
chr12_+_57488059 15.85 ENST00000628866.2
ENST00000262027.10
methionyl-tRNA synthetase 1
chr16_+_89948697 15.74 ENST00000567999.5
ENST00000610455.4
ENST00000617948.4
ENST00000566079.5
ENST00000566820.5
ENST00000562578.5
ENST00000563594.6
ENST00000561741.5
ENST00000268676.11
ENST00000562986.5
ENST00000569453.5
ENST00000567884.5
ENST00000569061.5
ENST00000418391.6
ENST00000561959.5
ENST00000567874.5
ENST00000570182.5
ENST00000563795.1
differentially expressed in FDCP 8 homolog
chr19_+_6361506 15.73 ENST00000245816.11
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr21_-_39183398 15.72 ENST00000331573.8
proteasome assembly chaperone 1
chr15_+_78540405 15.70 ENST00000560217.5
ENST00000559082.5
ENST00000559948.5
ENST00000413382.6
ENST00000559146.5
ENST00000044462.12
ENST00000558281.5
proteasome 20S subunit alpha 4
chr16_-_25015311 15.70 ENST00000303665.9
ENST00000455311.6
ENST00000289968.11
Rho GTPase activating protein 17
chr2_-_61888570 15.69 ENST00000394440.8
ENST00000544079.2
chaperonin containing TCP1 subunit 4
chr22_-_41947087 15.69 ENST00000407253.7
ENST00000215980.10
centromere protein M
chr20_+_3888772 15.67 ENST00000497424.5
pantothenate kinase 2
chr22_-_17199609 15.61 ENST00000330232.8
adenosine deaminase 2
chr6_+_31666802 15.55 ENST00000617558.2
novel protein
chrX_-_72277235 15.46 ENST00000316084.10
ribosomal protein S4 X-linked
chr5_+_172983763 15.26 ENST00000519374.6
ENST00000519911.5
ATPase H+ transporting V0 subunit e1
chr2_-_70293675 15.19 ENST00000454893.1
ENST00000272348.7
small nuclear ribonucleoprotein polypeptide G
chr16_+_29461386 15.12 ENST00000565290.5
sulfotransferase family 1A member 4
chr20_-_34303345 15.06 ENST00000217426.7
adenosylhomocysteinase
chr7_+_55951919 14.96 ENST00000443449.1
mitochondrial ribosomal protein S17
chr11_-_73982830 14.94 ENST00000536983.5
ENST00000663595.2
ENST00000310473.9
uncoupling protein 2
chr2_+_86199355 14.93 ENST00000254644.12
ENST00000605125.5
ENST00000337109.9
ENST00000409180.1
mitochondrial ribosomal protein L35
chr19_+_1071194 14.89 ENST00000543365.5
Rho GTPase activating protein 45
chr11_+_32583792 14.74 ENST00000531120.6
ENST00000524896.5
ENST00000323213.9
eukaryotic translation initiation factor 3 subunit M
chr17_+_78214186 14.69 ENST00000301633.8
ENST00000350051.8
ENST00000374948.6
ENST00000590449.1
baculoviral IAP repeat containing 5
chr1_-_31919368 14.64 ENST00000457805.6
ENST00000602725.5
ENST00000679970.1
protein tyrosine phosphatase 4A2
novel protein
chr6_+_31494881 14.60 ENST00000538442.5
MHC class I polypeptide-related sequence B
chr21_-_39183466 14.54 ENST00000380900.2
proteasome assembly chaperone 1
chr2_+_15591164 14.52 ENST00000381341.7
DEAD-box helicase 1
chr14_-_63508231 14.49 ENST00000422769.6
protein phosphatase 2 regulatory subunit B'epsilon
chr8_-_54022441 14.48 ENST00000396401.7
ENST00000521604.7
ENST00000640382.1
ENST00000640041.1
transcription elongation factor A1
chr1_+_40988513 14.45 ENST00000649215.1
CTP synthase 1
chr11_+_62761570 14.35 ENST00000301788.12
RNA polymerase II subunit G
chr11_-_118342691 14.31 ENST00000300692.9
CD3d molecule
chr11_+_75399508 14.27 ENST00000531188.6
ENST00000530164.5
ENST00000422465.6
ENST00000278572.10
ENST00000534440.5
ENST00000527446.5
ENST00000526608.5
ENST00000527273.5
ENST00000524851.5
ribosomal protein S3
chr1_-_154608140 14.27 ENST00000529168.2
ENST00000368474.9
ENST00000680305.1
ENST00000648231.2
adenosine deaminase RNA specific
chr16_-_31094549 14.26 ENST00000394971.7
vitamin K epoxide reductase complex subunit 1
chr1_-_145405778 14.20 ENST00000392971.6
NBPF member 20
chr19_-_2456924 14.19 ENST00000325327.4
lamin B2
chr13_+_25096130 14.15 ENST00000281589.5
poly(A) binding protein cytoplasmic 3
chr1_-_39576744 14.12 ENST00000372857.7
ENST00000372856.7
ENST00000531243.2
ENST00000372858.8
ENST00000451091.2
poly(A) binding protein cytoplasmic 4
chr6_-_31542339 14.03 ENST00000458640.5
DExD-box helicase 39B
chr12_+_93467506 14.00 ENST00000549982.6
ENST00000552217.6
ENST00000393128.8
ENST00000547098.5
mitochondrial ribosomal protein L42
chr2_+_186506713 14.00 ENST00000445547.1
zinc finger CCCH-type containing 15
chr8_-_100706931 13.95 ENST00000520868.5
poly(A) binding protein cytoplasmic 1
chr1_-_92075441 13.95 ENST00000596516.2
SET like protein
chr6_-_144095556 13.95 ENST00000367569.4
splicing factor 3b subunit 5
chr10_-_27154226 13.95 ENST00000427324.5
ENST00000375972.7
ENST00000326799.7
YME1 like 1 ATPase
chr15_+_65869974 13.88 ENST00000567671.1
RAB11A, member RAS oncogene family
chr1_+_84479239 13.87 ENST00000370656.5
ENST00000370654.6
ribosome production factor 1 homolog
chr11_-_11353241 13.82 ENST00000528848.3
casein kinase 2 alpha 3
chr15_-_63156774 13.79 ENST00000462430.5
ribosomal protein S27 like
chr6_-_31806937 13.78 ENST00000375661.6
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr7_+_74209989 13.71 ENST00000361082.7
ENST00000275635.11
ENST00000460943.6
ENST00000470709.1
linker for activation of T cells family member 2
chr5_-_181242236 13.70 ENST00000507756.5
receptor for activated C kinase 1
chr12_+_54498766 13.70 ENST00000545638.2
NCK associated protein 1 like
chr1_-_15809348 13.66 ENST00000483273.2
ubiquinol-cytochrome c reductase hinge protein like
chr5_-_177006692 13.57 ENST00000507513.1
ENST00000511320.6
ubiquitin interaction motif containing 1
chr2_+_218245426 13.53 ENST00000456575.1
actin related protein 2/3 complex subunit 2
chr11_-_118342645 13.49 ENST00000529594.5
CD3d molecule
chr6_-_28923932 13.49 ENST00000377199.4
ENST00000377194.7
tripartite motif containing 27
chr20_-_63951122 13.48 ENST00000369908.9
uridine-cytidine kinase 1 like 1
chr22_+_40346461 13.44 ENST00000623632.4
ENST00000625194.4
ENST00000637666.2
ENST00000680978.1
ENST00000623063.3
ENST00000679723.1
ENST00000342312.9
adenylosuccinate lyase
chr6_-_30744537 13.43 ENST00000259874.6
ENST00000376377.2
immediate early response 3
chr19_-_12957198 13.40 ENST00000316939.3
GADD45G interacting protein 1
chr17_-_58280928 13.39 ENST00000225275.4
myeloperoxidase
chr7_+_66921217 13.38 ENST00000341567.8
ENST00000607045.5
transmembrane protein 248
chr14_+_73490926 13.28 ENST00000304061.8
ribosomal oxygenase 1
chr19_+_5690255 13.21 ENST00000582463.5
ENST00000347512.8
ENST00000579446.1
ENST00000394580.2
ribosomal protein L36
chr14_-_34539655 13.15 ENST00000250454.8
ENST00000618169.4
E2F associated phosphoprotein
chr2_+_159733958 13.10 ENST00000409591.5
membrane associated ring-CH-type finger 7
chr3_-_33097132 12.93 ENST00000307363.10
ENST00000307377.12
ENST00000440656.1
ENST00000436768.1
ENST00000342462.5
galactosidase beta 1
transmembrane protein with metallophosphoesterase domain
chr5_+_156850292 12.91 ENST00000522232.3
PPP1R2 family member B
chr2_-_27134611 12.89 ENST00000406567.7
ENST00000260643.7
prolactin regulatory element binding
chr1_-_193106048 12.85 ENST00000367440.3
glutaredoxin 2
chr16_-_1963100 12.82 ENST00000526586.6
ribosomal protein S2
chr19_-_43656616 12.80 ENST00000593447.5
plasminogen activator, urokinase receptor
chr2_+_57907621 12.75 ENST00000648897.1
ENST00000435505.6
ENST00000417641.6
VRK serine/threonine kinase 2
chr2_-_151289613 12.65 ENST00000243346.10
N-myc and STAT interactor
chr11_-_67443785 12.58 ENST00000393893.5
ENST00000545016.2
coronin 1B
chr5_-_181242195 12.52 ENST00000502905.5
receptor for activated C kinase 1
chr16_-_375205 12.49 ENST00000448854.1
post-glycosylphosphatidylinositol attachment to proteins 6
chr10_-_27154365 12.47 ENST00000396296.7
ENST00000376016.8
ENST00000491542.6
ENST00000613434.4
YME1 like 1 ATPase
chr1_+_70205680 12.43 ENST00000370951.5
serine and arginine rich splicing factor 11
chr17_+_62458641 12.43 ENST00000582809.5
tousled like kinase 2
chr19_+_23117018 12.41 ENST00000597761.7
zinc finger protein 730
chr1_+_165827574 12.41 ENST00000367879.9
uridine-cytidine kinase 2
chr3_-_142000353 12.40 ENST00000499676.5
transcription factor Dp-2
chr14_-_55191534 12.40 ENST00000395425.6
ENST00000247191.7
DLG associated protein 5
chr12_-_120201099 12.39 ENST00000551150.5
ENST00000313104.9
ENST00000547191.5
ENST00000546989.5
ENST00000392514.9
ENST00000228306.8
ENST00000550856.5
ribosomal protein lateral stalk subunit P0
chr15_+_80072559 12.35 ENST00000560228.5
ENST00000559835.5
ENST00000559775.5
ENST00000558688.5
ENST00000560392.5
ENST00000560976.5
ENST00000558272.5
ENST00000558390.5
zinc finger AN1-type containing 6
chr5_-_177006581 12.34 ENST00000506128.5
ubiquitin interaction motif containing 1
chr1_+_32222415 12.32 ENST00000678420.1
ENST00000678162.1
ENST00000678711.1
ENST00000678883.1
ENST00000677353.1
ENST00000355082.10
eukaryotic translation initiation factor 3 subunit I

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 34.1 GO:0072019 proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
11.1 77.9 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
11.0 32.9 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
9.4 28.3 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
9.2 73.3 GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051343)
9.0 36.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
8.2 106.7 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
8.1 32.4 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
7.4 44.2 GO:0007341 penetration of zona pellucida(GO:0007341)
7.3 22.0 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
7.0 70.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
6.5 45.8 GO:0010216 maintenance of DNA methylation(GO:0010216)
6.3 31.3 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
6.2 24.9 GO:0003290 atrial septum secundum morphogenesis(GO:0003290)
5.9 35.7 GO:0044211 CTP salvage(GO:0044211)
5.6 33.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
5.5 22.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
5.5 32.8 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
5.5 21.8 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
5.2 15.6 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
5.1 20.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
5.0 15.0 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
4.9 9.7 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
4.8 33.5 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
4.8 14.3 GO:1905053 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
4.7 9.4 GO:0034729 histone H3-K79 methylation(GO:0034729)
4.6 13.9 GO:0010796 regulation of multivesicular body size(GO:0010796)
4.5 59.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
4.4 17.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
4.3 38.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
4.3 4.3 GO:0046984 regulation of hemoglobin biosynthetic process(GO:0046984)
4.2 16.9 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
4.2 12.7 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
4.2 92.6 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
4.2 46.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
4.2 25.2 GO:1990539 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
4.2 33.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
4.1 12.4 GO:0006059 hexitol metabolic process(GO:0006059)
4.1 32.5 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
4.0 11.9 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)
3.9 43.4 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
3.8 19.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
3.8 26.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
3.7 40.7 GO:1901977 negative regulation of cell cycle checkpoint(GO:1901977)
3.6 10.9 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
3.5 31.9 GO:0006167 AMP biosynthetic process(GO:0006167)
3.5 31.3 GO:0000710 meiotic mismatch repair(GO:0000710)
3.5 20.8 GO:2001184 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
3.4 23.8 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
3.4 13.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
3.3 13.3 GO:0030961 peptidyl-arginine hydroxylation(GO:0030961)
3.2 9.6 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
3.2 9.5 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
3.2 6.3 GO:0071035 polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046)
3.1 6.3 GO:0034769 basement membrane disassembly(GO:0034769)
3.1 34.4 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
3.1 9.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
3.1 6.2 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
3.0 33.5 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
3.0 18.0 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
3.0 12.0 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
2.9 123.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
2.9 23.1 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
2.8 11.1 GO:0071879 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879) negative regulation of type B pancreatic cell development(GO:2000077)
2.8 41.3 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
2.7 19.0 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
2.7 8.1 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
2.7 37.3 GO:0045059 positive thymic T cell selection(GO:0045059)
2.6 7.8 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
2.6 10.3 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
2.6 5.1 GO:0014806 smooth muscle hyperplasia(GO:0014806)
2.6 20.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
2.5 5.1 GO:0032262 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
2.5 7.6 GO:0002339 B cell selection(GO:0002339)
2.5 7.5 GO:0036233 glycine import(GO:0036233)
2.5 94.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
2.5 14.9 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
2.5 12.4 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
2.5 52.0 GO:0032060 bleb assembly(GO:0032060)
2.4 9.5 GO:0070981 L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
2.3 9.4 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
2.3 11.5 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
2.3 13.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.2 36.0 GO:0043248 proteasome assembly(GO:0043248)
2.2 28.9 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
2.2 8.8 GO:0035803 egg coat formation(GO:0035803)
2.2 6.6 GO:0035915 pore formation in membrane of other organism(GO:0035915)
2.2 41.4 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
2.2 12.9 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
2.1 18.8 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
2.1 6.2 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
2.0 2.0 GO:0060467 negative regulation of fertilization(GO:0060467)
2.0 18.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
2.0 3.9 GO:0019249 lactate biosynthetic process(GO:0019249)
1.9 73.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
1.9 13.4 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
1.9 158.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
1.9 9.3 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
1.9 9.3 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
1.8 9.2 GO:0006741 NADP biosynthetic process(GO:0006741)
1.8 5.5 GO:0034402 mRNA export from nucleus in response to heat stress(GO:0031990) recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
1.8 20.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.8 59.8 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
1.8 10.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.8 7.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
1.8 82.0 GO:0000303 response to superoxide(GO:0000303)
1.8 3.6 GO:0097167 circadian regulation of translation(GO:0097167)
1.8 10.5 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
1.7 1.7 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
1.7 8.4 GO:0019323 pentose catabolic process(GO:0019323)
1.7 16.8 GO:0046689 response to mercury ion(GO:0046689)
1.7 5.0 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
1.6 35.4 GO:0006337 nucleosome disassembly(GO:0006337)
1.6 26.9 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
1.6 15.6 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
1.6 18.8 GO:0015939 pantothenate metabolic process(GO:0015939)
1.5 86.8 GO:0050434 positive regulation of viral transcription(GO:0050434)
1.5 1.5 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
1.5 6.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.5 10.8 GO:0032497 detection of lipopolysaccharide(GO:0032497)
1.5 111.7 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.5 7.6 GO:0033277 abortive mitotic cell cycle(GO:0033277)
1.5 6.1 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
1.5 3.0 GO:0010899 regulation of phosphatidylcholine catabolic process(GO:0010899)
1.5 20.9 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
1.5 8.9 GO:0070383 DNA cytosine deamination(GO:0070383)
1.5 4.4 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
1.5 13.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
1.5 5.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.4 29.0 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
1.4 8.7 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
1.4 4.3 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
1.4 11.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
1.4 13.9 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
1.4 5.5 GO:0050902 leukocyte adhesive activation(GO:0050902)
1.4 9.5 GO:0035879 plasma membrane lactate transport(GO:0035879)
1.3 6.6 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
1.3 11.9 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
1.3 21.1 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.3 15.7 GO:0042373 vitamin K metabolic process(GO:0042373)
1.3 10.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
1.3 18.0 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
1.3 45.0 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.3 111.8 GO:0002181 cytoplasmic translation(GO:0002181)
1.3 10.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
1.3 17.6 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.2 17.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
1.2 6.0 GO:2000210 positive regulation of anoikis(GO:2000210)
1.2 3.6 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
1.2 2.4 GO:0070837 dehydroascorbic acid transport(GO:0070837)
1.2 6.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.2 109.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
1.2 3.5 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
1.2 18.5 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
1.1 3.4 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
1.1 3.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
1.1 6.8 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
1.1 5.6 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
1.1 20.1 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
1.1 7.8 GO:0071501 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
1.1 6.6 GO:0003051 angiotensin catabolic process in blood(GO:0002005) angiotensin-mediated drinking behavior(GO:0003051) multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266)
1.1 22.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.1 15.4 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581)
1.1 6.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.1 9.5 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
1.1 6.3 GO:0015693 magnesium ion transport(GO:0015693)
1.0 5.2 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
1.0 4.1 GO:0008215 spermine metabolic process(GO:0008215)
1.0 2.0 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
1.0 26.9 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
1.0 3.0 GO:0046521 sphingoid catabolic process(GO:0046521)
1.0 12.8 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
1.0 13.7 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.0 56.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.9 65.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.9 11.1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.9 3.7 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.9 4.5 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.9 12.5 GO:0043486 histone exchange(GO:0043486)
0.9 34.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.9 8.5 GO:0006116 NADH oxidation(GO:0006116)
0.8 11.0 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.8 1.6 GO:0031291 Ran protein signal transduction(GO:0031291)
0.8 1.6 GO:0006772 thiamine metabolic process(GO:0006772)
0.8 18.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.8 18.5 GO:0016578 histone deubiquitination(GO:0016578)
0.8 7.2 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566)
0.8 19.9 GO:0000042 protein targeting to Golgi(GO:0000042)
0.8 7.1 GO:0045047 protein targeting to ER(GO:0045047)
0.8 4.0 GO:1902044 regulation of Fas signaling pathway(GO:1902044) positive regulation of blood vessel remodeling(GO:2000504)
0.8 2.4 GO:0042631 cellular response to water deprivation(GO:0042631)
0.8 3.9 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.8 3.9 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.8 20.8 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.8 1.5 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.8 15.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.8 1.5 GO:0006711 estrogen catabolic process(GO:0006711)
0.8 5.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.8 27.3 GO:0035456 response to interferon-beta(GO:0035456)
0.8 6.8 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.7 3.7 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
0.7 3.0 GO:1903899 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.7 5.9 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.7 7.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.7 51.9 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.7 3.6 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.7 9.4 GO:0006089 lactate metabolic process(GO:0006089)
0.7 4.2 GO:0070475 rRNA base methylation(GO:0070475)
0.7 16.3 GO:0006270 DNA replication initiation(GO:0006270)
0.7 4.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.7 63.4 GO:0006413 translational initiation(GO:0006413)
0.7 3.3 GO:0098502 DNA dephosphorylation(GO:0098502)
0.6 7.1 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.6 3.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.6 8.9 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.6 2.5 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.6 3.7 GO:0006642 triglyceride mobilization(GO:0006642)
0.6 8.0 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.6 2.4 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.6 4.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.6 1.7 GO:1902896 terminal web assembly(GO:1902896)
0.6 9.3 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.6 2.9 GO:1901094 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.6 9.1 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.6 3.4 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.6 10.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.6 5.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.6 3.4 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.6 2.8 GO:0016139 glycoside catabolic process(GO:0016139)
0.6 2.2 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.6 5.0 GO:2000582 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.5 2.7 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 3.8 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.5 1.6 GO:0032289 central nervous system myelin formation(GO:0032289)
0.5 1.6 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.5 5.4 GO:0051601 exocyst localization(GO:0051601)
0.5 3.7 GO:0048194 Golgi vesicle budding(GO:0048194)
0.5 2.7 GO:0009609 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943) positive regulation of leukocyte tethering or rolling(GO:1903238) positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.5 5.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.5 1.6 GO:0042704 negative regulation of alkaline phosphatase activity(GO:0010693) uterine wall breakdown(GO:0042704)
0.5 5.2 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.5 4.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.5 2.1 GO:0070316 regulation of G0 to G1 transition(GO:0070316)
0.5 11.7 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.5 1.0 GO:0033007 negative regulation of mast cell activation involved in immune response(GO:0033007)
0.5 8.7 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.5 1.4 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.5 0.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.5 13.8 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.5 7.5 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.5 8.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.5 6.4 GO:0006465 signal peptide processing(GO:0006465)
0.5 43.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.4 1.3 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.4 5.3 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.4 18.0 GO:0061615 NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.4 23.7 GO:0018208 peptidyl-proline modification(GO:0018208)
0.4 2.6 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.4 5.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.4 105.3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.4 0.4 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.4 1.6 GO:0006265 DNA topological change(GO:0006265)
0.4 25.9 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.4 5.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.4 1.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.4 1.1 GO:0048539 bone marrow development(GO:0048539)
0.4 4.9 GO:0016540 protein autoprocessing(GO:0016540)
0.4 6.8 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.4 8.3 GO:0022904 respiratory electron transport chain(GO:0022904)
0.4 21.6 GO:0006334 nucleosome assembly(GO:0006334)
0.4 4.8 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.4 1.1 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.4 2.5 GO:0040016 embryonic cleavage(GO:0040016)
0.4 6.0 GO:0048240 sperm capacitation(GO:0048240)
0.4 0.7 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
0.3 3.8 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.3 2.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 3.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.3 6.2 GO:0003351 epithelial cilium movement(GO:0003351)
0.3 10.0 GO:0043171 peptide catabolic process(GO:0043171)
0.3 3.6 GO:0030916 otic vesicle formation(GO:0030916)
0.3 4.3 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.3 1.0 GO:0051039 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.3 2.9 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.3 3.8 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.3 2.2 GO:0036343 psychomotor behavior(GO:0036343)
0.3 1.8 GO:0014057 positive regulation of glutamate secretion(GO:0014049) positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.3 6.1 GO:0032418 lysosome localization(GO:0032418)
0.3 9.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 6.0 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.3 4.4 GO:0042832 defense response to protozoan(GO:0042832)
0.3 7.3 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.3 1.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.3 10.9 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.3 2.2 GO:0019321 pentose metabolic process(GO:0019321)
0.3 1.4 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.3 0.8 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.3 15.3 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.3 1.0 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 2.9 GO:0006552 leucine catabolic process(GO:0006552)
0.3 16.8 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
0.3 5.0 GO:2000696 regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.2 1.0 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.2 5.0 GO:0006266 DNA ligation(GO:0006266)
0.2 2.0 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2 9.3 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.2 0.9 GO:0000023 maltose metabolic process(GO:0000023)
0.2 14.7 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.2 1.4 GO:1903911 positive regulation of receptor clustering(GO:1903911)
0.2 5.0 GO:0006833 water transport(GO:0006833)
0.2 8.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 8.3 GO:0051693 actin filament capping(GO:0051693)
0.2 3.1 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 2.1 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.2 1.5 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 3.7 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.2 0.8 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.2 2.9 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.2 3.4 GO:0044065 regulation of respiratory system process(GO:0044065)
0.2 1.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 8.6 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 1.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 1.8 GO:0015871 choline transport(GO:0015871)
0.2 1.8 GO:0070166 enamel mineralization(GO:0070166)
0.2 3.3 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.2 7.8 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 2.2 GO:0032329 serine transport(GO:0032329)
0.2 0.5 GO:0044805 late nucleophagy(GO:0044805)
0.2 9.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 1.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.2 0.8 GO:1904646 cellular response to beta-amyloid(GO:1904646)
0.2 4.1 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.2 1.5 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 1.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 12.1 GO:0034340 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 3.3 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 4.7 GO:2001044 regulation of integrin-mediated signaling pathway(GO:2001044)
0.1 1.7 GO:0016180 snRNA processing(GO:0016180)
0.1 3.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 3.7 GO:0032438 melanosome organization(GO:0032438)
0.1 3.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.3 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 1.0 GO:0006734 NADH metabolic process(GO:0006734)
0.1 1.6 GO:0033622 integrin activation(GO:0033622)
0.1 4.0 GO:0001881 receptor recycling(GO:0001881)
0.1 1.6 GO:0006071 glycerol metabolic process(GO:0006071)
0.1 3.1 GO:0006414 translational elongation(GO:0006414)
0.1 14.0 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.3 GO:0043605 cellular amide catabolic process(GO:0043605)
0.1 9.3 GO:0016573 histone acetylation(GO:0016573)
0.1 2.8 GO:0023058 adaptation of signaling pathway(GO:0023058)
0.1 4.9 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 2.1 GO:0097320 membrane tubulation(GO:0097320)
0.1 10.5 GO:0016575 histone deacetylation(GO:0016575)
0.1 4.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 1.9 GO:0050832 defense response to fungus(GO:0050832)
0.1 4.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 8.3 GO:0051149 positive regulation of muscle cell differentiation(GO:0051149)
0.1 1.7 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.1 2.9 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.1 2.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 0.8 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.1 1.2 GO:0051660 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660)
0.1 2.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 2.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 6.9 GO:0008344 adult locomotory behavior(GO:0008344)
0.1 9.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 1.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 29.1 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.1 3.2 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.1 0.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 1.8 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.1 0.4 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.1 0.3 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.1 0.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 2.8 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 3.2 GO:0046324 regulation of glucose import(GO:0046324)
0.1 1.0 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.3 GO:0072319 synaptic vesicle uncoating(GO:0016191) vesicle uncoating(GO:0072319)
0.0 3.4 GO:0008033 tRNA processing(GO:0008033)
0.0 0.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.3 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.2 GO:1902713 regulation of interferon-gamma secretion(GO:1902713) positive regulation of interferon-gamma secretion(GO:1902715)
0.0 2.0 GO:0021766 hippocampus development(GO:0021766)
0.0 4.2 GO:0002431 Fc receptor mediated stimulatory signaling pathway(GO:0002431)
0.0 1.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.3 GO:0007077 mitotic nuclear envelope disassembly(GO:0007077)
0.0 0.7 GO:0001662 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0 0.3 GO:0045730 respiratory burst(GO:0045730)
0.0 1.0 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.0 GO:0060177 regulation of angiotensin levels in blood(GO:0002002) angiotensin maturation(GO:0002003) drinking behavior(GO:0042756) regulation of angiotensin metabolic process(GO:0060177)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.6 31.7 GO:0036284 tubulobulbar complex(GO:0036284)
10.5 73.8 GO:0034715 pICln-Sm protein complex(GO:0034715)
10.2 91.7 GO:0034709 methylosome(GO:0034709)
10.1 30.3 GO:0030289 protein phosphatase 4 complex(GO:0030289)
9.7 106.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
8.1 73.3 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
8.1 32.4 GO:0005715 late recombination nodule(GO:0005715)
6.3 44.3 GO:0005687 U4 snRNP(GO:0005687)
6.3 31.3 GO:0032301 MutSalpha complex(GO:0032301)
5.7 11.4 GO:0002079 inner acrosomal membrane(GO:0002079)
5.6 22.6 GO:0071920 cleavage body(GO:0071920)
5.5 49.7 GO:0032133 chromosome passenger complex(GO:0032133)
5.4 43.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
4.9 58.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
4.7 32.8 GO:0044530 supraspliceosomal complex(GO:0044530)
4.5 13.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
4.5 31.3 GO:0032021 NELF complex(GO:0032021)
4.4 26.2 GO:0009368 endopeptidase Clp complex(GO:0009368)
4.3 56.0 GO:0042555 MCM complex(GO:0042555)
4.2 20.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
4.1 44.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
4.0 20.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
4.0 11.9 GO:0002081 outer acrosomal membrane(GO:0002081)
3.8 38.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
3.7 99.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
3.6 68.4 GO:0097431 mitotic spindle pole(GO:0097431)
3.6 14.3 GO:0071159 NF-kappaB complex(GO:0071159)
3.5 42.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
3.4 30.8 GO:0070652 HAUS complex(GO:0070652)
3.4 23.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
3.4 10.2 GO:0044611 nuclear pore inner ring(GO:0044611)
3.3 52.8 GO:0005642 annulate lamellae(GO:0005642)
3.2 29.2 GO:0031298 replication fork protection complex(GO:0031298)
3.1 6.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
3.1 18.5 GO:0001940 male pronucleus(GO:0001940)
3.0 39.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
2.9 8.7 GO:0055087 Ski complex(GO:0055087)
2.9 48.7 GO:0031080 nuclear pore outer ring(GO:0031080)
2.8 19.9 GO:0034719 SMN-Sm protein complex(GO:0034719)
2.8 13.9 GO:0098837 postsynaptic recycling endosome(GO:0098837)
2.8 13.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
2.7 53.2 GO:0005839 proteasome core complex(GO:0005839)
2.6 7.9 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
2.6 7.8 GO:1990038 glial cytoplasmic inclusion(GO:0097409) classical Lewy body(GO:0097414) Lewy neurite(GO:0097462) Lewy body corona(GO:1990038)
2.6 20.9 GO:0005672 transcription factor TFIIA complex(GO:0005672)
2.5 20.4 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
2.5 10.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
2.4 60.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
2.4 42.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
2.3 11.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
2.2 11.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
2.2 23.9 GO:0005638 lamin filament(GO:0005638)
2.2 6.5 GO:0000799 nuclear condensin complex(GO:0000799)
2.1 31.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
2.1 64.3 GO:0005838 proteasome regulatory particle(GO:0005838)
2.1 195.9 GO:0015935 small ribosomal subunit(GO:0015935)
2.1 10.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
2.0 28.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
1.9 17.2 GO:0000813 ESCRT I complex(GO:0000813)
1.9 11.1 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
1.9 14.8 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
1.9 25.9 GO:0070531 BRCA1-A complex(GO:0070531)
1.7 15.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.7 13.3 GO:0070761 pre-snoRNP complex(GO:0070761)
1.7 16.7 GO:0061574 ASAP complex(GO:0061574)
1.6 169.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.6 4.7 GO:0034457 Mpp10 complex(GO:0034457)
1.6 9.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.5 13.6 GO:0005787 signal peptidase complex(GO:0005787)
1.5 4.5 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
1.5 18.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.4 20.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
1.4 18.5 GO:0070938 contractile ring(GO:0070938)
1.4 176.9 GO:0035578 azurophil granule lumen(GO:0035578)
1.4 62.0 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
1.4 6.9 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.4 37.0 GO:0005719 nuclear euchromatin(GO:0005719)
1.3 5.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.2 13.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.2 12.2 GO:0035686 sperm fibrous sheath(GO:0035686)
1.2 15.2 GO:0031209 SCAR complex(GO:0031209)
1.1 17.2 GO:0071438 invadopodium membrane(GO:0071438)
1.1 11.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.1 4.3 GO:0070876 SOSS complex(GO:0070876)
1.1 17.0 GO:0031083 BLOC-1 complex(GO:0031083)
1.1 7.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
1.1 4.2 GO:1990879 CST complex(GO:1990879)
1.0 12.6 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179)
1.0 8.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.9 22.7 GO:0035371 microtubule plus-end(GO:0035371)
0.9 10.3 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.9 6.3 GO:0000812 Swr1 complex(GO:0000812)
0.9 6.3 GO:0036021 endolysosome lumen(GO:0036021)
0.9 12.5 GO:0032433 filopodium tip(GO:0032433)
0.8 15.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.8 10.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.8 33.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.8 14.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.8 6.6 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.8 2.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.7 6.0 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.7 16.8 GO:0002080 acrosomal membrane(GO:0002080)
0.7 5.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.7 11.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.6 115.0 GO:0005681 spliceosomal complex(GO:0005681)
0.6 0.6 GO:0043296 apical junction complex(GO:0043296)
0.6 22.2 GO:0042629 mast cell granule(GO:0042629)
0.6 35.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.6 6.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.6 22.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.6 18.8 GO:0071564 npBAF complex(GO:0071564)
0.5 14.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.5 10.3 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.5 12.4 GO:0030904 retromer complex(GO:0030904)
0.5 3.8 GO:0042788 polysomal ribosome(GO:0042788)
0.5 4.7 GO:0044754 autolysosome(GO:0044754)
0.5 8.4 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.5 31.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.5 3.9 GO:0030891 VCB complex(GO:0030891)
0.5 5.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 27.0 GO:0030684 preribosome(GO:0030684)
0.4 5.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 34.4 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.4 4.4 GO:0060171 stereocilium membrane(GO:0060171)
0.4 18.2 GO:0016235 aggresome(GO:0016235)
0.4 1.5 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.4 1.2 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.4 2.7 GO:0070821 tertiary granule membrane(GO:0070821)
0.4 4.3 GO:0097486 multivesicular body lumen(GO:0097486)
0.3 48.2 GO:0016605 PML body(GO:0016605)
0.3 39.5 GO:0000922 spindle pole(GO:0000922)
0.3 1.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3 5.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.3 5.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.3 28.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.3 3.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3 5.4 GO:0000145 exocyst(GO:0000145)
0.3 3.8 GO:0030681 multimeric ribonuclease P complex(GO:0030681)
0.3 3.0 GO:0097443 sorting endosome(GO:0097443)
0.3 6.0 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 3.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 17.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.3 15.3 GO:0001772 immunological synapse(GO:0001772)
0.3 3.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 3.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.3 3.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 1.6 GO:0097451 glial limiting end-foot(GO:0097451)
0.3 14.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 6.7 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.3 4.6 GO:0042611 MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)
0.3 16.9 GO:0005643 nuclear pore(GO:0005643)
0.2 2.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 2.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 22.0 GO:0035579 specific granule membrane(GO:0035579)
0.2 7.4 GO:0000502 proteasome complex(GO:0000502)
0.2 5.8 GO:0031143 pseudopodium(GO:0031143)
0.2 3.2 GO:0001891 phagocytic cup(GO:0001891)
0.2 5.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 10.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 4.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 1.7 GO:0032039 integrator complex(GO:0032039)
0.2 3.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 1.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 2.7 GO:0005922 connexon complex(GO:0005922)
0.1 13.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 7.6 GO:0032153 cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610)
0.1 15.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 6.0 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 10.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.8 GO:1990130 Iml1 complex(GO:1990130)
0.1 7.1 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 0.3 GO:0042587 glycogen granule(GO:0042587)
0.1 1.8 GO:0036452 ESCRT complex(GO:0036452)
0.1 8.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 26.1 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.1 5.1 GO:0045171 intercellular bridge(GO:0045171)
0.1 8.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 33.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 34.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.7 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)
0.1 9.3 GO:0005604 basement membrane(GO:0005604)
0.1 12.1 GO:0005923 bicellular tight junction(GO:0005923)
0.1 6.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.7 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.5 GO:0005921 gap junction(GO:0005921)
0.1 3.5 GO:0035580 specific granule lumen(GO:0035580)
0.1 1.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.3 GO:0032010 phagolysosome(GO:0032010)
0.0 2.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 8.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 5.2 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0097546 ciliary base(GO:0097546)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 75.0 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
11.1 66.5 GO:1990446 U1 snRNP binding(GO:1990446)
9.1 36.3 GO:0047685 amine sulfotransferase activity(GO:0047685)
8.5 34.1 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
8.3 25.0 GO:0004766 spermidine synthase activity(GO:0004766)
7.8 23.3 GO:0043035 chromatin insulator sequence binding(GO:0043035)
7.4 44.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
7.3 73.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
6.7 20.2 GO:0003896 DNA primase activity(GO:0003896)
6.3 31.3 GO:0032143 single thymine insertion binding(GO:0032143)
6.3 50.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
6.2 43.7 GO:0004849 uridine kinase activity(GO:0004849)
5.9 58.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
5.8 23.3 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
5.6 22.6 GO:0033677 DNA/RNA helicase activity(GO:0033677)
5.6 50.2 GO:0030621 U4 snRNA binding(GO:0030621)
5.5 22.0 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
5.5 21.8 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
5.4 43.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
5.3 16.0 GO:0080101 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
5.0 30.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
4.9 29.3 GO:0019237 centromeric DNA binding(GO:0019237)
4.7 18.7 GO:0043273 CTPase activity(GO:0043273)
4.6 18.6 GO:0042134 rRNA primary transcript binding(GO:0042134)
4.6 32.4 GO:0032137 guanine/thymine mispair binding(GO:0032137)
4.5 17.9 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
4.5 44.5 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
4.3 17.3 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
4.2 16.9 GO:0003883 CTP synthase activity(GO:0003883)
4.2 25.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
4.2 33.3 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
4.1 32.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
3.8 84.3 GO:0008494 translation activator activity(GO:0008494)
3.8 60.4 GO:0004000 adenosine deaminase activity(GO:0004000)
3.8 56.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
3.7 14.9 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
3.6 14.3 GO:0032357 oxidized purine DNA binding(GO:0032357)
3.5 31.9 GO:0016842 amidine-lyase activity(GO:0016842)
3.5 62.6 GO:0001055 RNA polymerase II activity(GO:0001055)
3.2 9.6 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
3.1 28.3 GO:0035174 histone serine kinase activity(GO:0035174)
3.1 9.4 GO:0004750 ribulose-phosphate 3-epimerase activity(GO:0004750)
3.1 18.4 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
3.0 20.9 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
3.0 106.7 GO:0005540 hyaluronic acid binding(GO:0005540)
2.9 26.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
2.8 34.0 GO:0070087 chromo shadow domain binding(GO:0070087)
2.8 8.5 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
2.7 11.0 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
2.7 21.4 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
2.6 15.8 GO:1990226 histone methyltransferase binding(GO:1990226)
2.6 15.7 GO:0004594 pantothenate kinase activity(GO:0004594)
2.6 15.7 GO:0047057 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
2.6 13.0 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
2.5 22.7 GO:0032190 acrosin binding(GO:0032190)
2.5 42.4 GO:0003688 DNA replication origin binding(GO:0003688)
2.4 67.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
2.3 7.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
2.3 11.5 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
2.2 13.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
2.2 58.2 GO:0070628 proteasome binding(GO:0070628)
2.1 8.3 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
2.0 9.9 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
1.9 84.8 GO:0031369 translation initiation factor binding(GO:0031369)
1.9 13.4 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
1.9 9.5 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
1.9 20.8 GO:0051525 NFAT protein binding(GO:0051525)
1.8 12.8 GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
1.8 5.4 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
1.8 8.9 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
1.7 8.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.7 6.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
1.7 5.1 GO:0008169 C-methyltransferase activity(GO:0008169)
1.7 10.3 GO:1990763 arrestin family protein binding(GO:1990763)
1.7 13.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.7 13.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
1.7 340.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.7 5.0 GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity(GO:0033699)
1.6 4.9 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.6 14.6 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
1.6 41.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
1.6 11.1 GO:0030369 ICAM-3 receptor activity(GO:0030369)
1.5 6.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.5 4.5 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
1.5 7.5 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
1.4 15.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.4 38.8 GO:0070717 poly-purine tract binding(GO:0070717)
1.4 10.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
1.3 9.4 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
1.3 4.0 GO:0002046 opsin binding(GO:0002046)
1.3 6.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
1.3 7.9 GO:0034511 U3 snoRNA binding(GO:0034511)
1.3 20.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
1.2 9.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.2 9.9 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
1.2 21.4 GO:0070034 telomerase RNA binding(GO:0070034)
1.2 4.8 GO:0004335 galactokinase activity(GO:0004335)
1.2 3.5 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
1.2 12.8 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
1.2 9.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
1.1 3.4 GO:0047315 kynurenine-glyoxylate transaminase activity(GO:0047315)
1.1 13.3 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
1.1 3.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
1.1 46.7 GO:0008536 Ran GTPase binding(GO:0008536)
1.1 7.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
1.0 18.8 GO:0030957 Tat protein binding(GO:0030957)
1.0 43.6 GO:0004532 exoribonuclease activity(GO:0004532)
1.0 18.7 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
1.0 5.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
1.0 25.6 GO:0031489 myosin V binding(GO:0031489)
1.0 33.4 GO:0001671 ATPase activator activity(GO:0001671)
1.0 8.8 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.0 14.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.9 6.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.9 125.5 GO:0043130 ubiquitin binding(GO:0043130)
0.9 8.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.9 19.5 GO:0030515 snoRNA binding(GO:0030515)
0.9 46.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.9 47.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.9 4.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.9 5.1 GO:0004630 phospholipase D activity(GO:0004630)
0.9 15.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.9 6.0 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.8 8.5 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.8 9.3 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.8 39.8 GO:0050699 WW domain binding(GO:0050699)
0.8 3.3 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.8 4.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.8 2.4 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.8 6.4 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.8 4.8 GO:0003998 acylphosphatase activity(GO:0003998)
0.8 2.4 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.8 4.0 GO:0050436 microfibril binding(GO:0050436)
0.8 9.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.8 6.3 GO:0008097 5S rRNA binding(GO:0008097)
0.8 3.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.8 40.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.7 2.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.7 6.0 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.7 16.3 GO:0005537 mannose binding(GO:0005537)
0.7 2.2 GO:0019150 D-ribulokinase activity(GO:0019150)
0.7 14.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.7 5.8 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.7 5.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.7 0.7 GO:0003909 DNA ligase activity(GO:0003909)
0.7 4.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.7 21.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.7 14.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.7 8.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 32.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.6 12.1 GO:0051400 BH domain binding(GO:0051400)
0.6 3.2 GO:0004905 type I interferon receptor activity(GO:0004905)
0.6 23.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.6 2.4 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.6 3.6 GO:0003680 AT DNA binding(GO:0003680)
0.6 8.8 GO:0015926 glucosidase activity(GO:0015926)
0.6 28.8 GO:0042169 SH2 domain binding(GO:0042169)
0.6 16.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.6 19.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.6 4.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.6 9.1 GO:0035497 cAMP response element binding(GO:0035497)
0.6 31.6 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.6 6.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.6 11.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.5 28.8 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 27.8 GO:0016859 cis-trans isomerase activity(GO:0016859)
0.5 3.6 GO:0016778 diphosphotransferase activity(GO:0016778)
0.5 11.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.5 3.4 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.5 1.0 GO:0004470 malic enzyme activity(GO:0004470)
0.5 1.4 GO:0032089 NACHT domain binding(GO:0032089)
0.5 8.2 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.5 2.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.5 5.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.5 1.4 GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity(GO:0004577)
0.5 6.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.4 1.3 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.4 5.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 3.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.4 3.8 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.4 6.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 9.2 GO:0003951 NAD+ kinase activity(GO:0003951)
0.4 0.4 GO:0004461 lactose synthase activity(GO:0004461)
0.4 11.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.4 1.6 GO:0004802 transketolase activity(GO:0004802)
0.4 5.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 10.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 4.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.4 6.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.4 7.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 3.0 GO:0035198 miRNA binding(GO:0035198)
0.4 3.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.4 12.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 4.8 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.4 1.1 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.4 6.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.4 18.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 4.1 GO:0015929 hexosaminidase activity(GO:0015929)
0.3 4.6 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 2.9 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.3 1.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 10.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 9.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 8.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 1.8 GO:0039552 RIG-I binding(GO:0039552)
0.3 2.9 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.3 25.9 GO:0042393 histone binding(GO:0042393)
0.3 6.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.3 17.1 GO:0035064 methylated histone binding(GO:0035064)
0.3 26.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.3 2.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 4.4 GO:0015250 water channel activity(GO:0015250)
0.3 1.6 GO:0005499 vitamin D binding(GO:0005499)
0.3 2.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.3 0.8 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.3 0.8 GO:0005124 scavenger receptor binding(GO:0005124)
0.3 10.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 12.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 6.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 0.5 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.2 3.2 GO:0008199 ferric iron binding(GO:0008199)
0.2 3.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 5.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.7 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.2 3.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 8.0 GO:0043022 ribosome binding(GO:0043022)
0.2 3.1 GO:0031014 troponin T binding(GO:0031014)
0.2 8.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.2 6.3 GO:0031491 nucleosome binding(GO:0031491)
0.2 14.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 2.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 45.0 GO:0051015 actin filament binding(GO:0051015)
0.2 1.6 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.2 10.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 0.8 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 3.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 6.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 3.4 GO:0016849 phosphorus-oxygen lyase activity(GO:0016849)
0.2 25.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 3.1 GO:0097602 cullin family protein binding(GO:0097602)
0.2 8.7 GO:0005158 insulin receptor binding(GO:0005158)
0.2 13.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 0.8 GO:0004771 sterol esterase activity(GO:0004771)
0.2 2.9 GO:0070064 proline-rich region binding(GO:0070064)
0.2 4.3 GO:0001968 fibronectin binding(GO:0001968)
0.2 5.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 1.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 2.4 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 3.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 49.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 1.5 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.1 9.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 2.2 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 4.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.0 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.5 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.0 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 0.3 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 1.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 2.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 2.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 1.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 7.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 28.6 GO:0045296 cadherin binding(GO:0045296)
0.1 0.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 12.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 1.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 21.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.9 GO:0043274 phospholipase binding(GO:0043274)
0.1 3.0 GO:0004540 ribonuclease activity(GO:0004540)
0.1 2.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 6.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.3 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.4 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 4.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.7 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 3.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.2 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 6.9 GO:0005125 cytokine activity(GO:0005125)
0.0 4.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 12.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.0 0.3 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.8 GO:0051287 NAD binding(GO:0051287)
0.0 1.4 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 1.0 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.1 GO:0004955 prostaglandin receptor activity(GO:0004955)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 99.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.0 46.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
1.4 88.4 PID AURORA B PATHWAY Aurora B signaling
1.4 51.5 PID ATM PATHWAY ATM pathway
1.2 73.9 PID ATR PATHWAY ATR signaling pathway
1.0 98.6 PID RAC1 PATHWAY RAC1 signaling pathway
1.0 47.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.9 31.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.9 26.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.8 8.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.7 45.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.7 33.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.7 18.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.6 17.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.6 15.5 PID AURORA A PATHWAY Aurora A signaling
0.6 56.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.6 15.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 122.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.6 17.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5 16.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.5 11.3 PID IL23 PATHWAY IL23-mediated signaling events
0.5 16.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.5 25.4 PID FOXO PATHWAY FoxO family signaling
0.4 9.3 PID EPO PATHWAY EPO signaling pathway
0.4 10.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 5.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 10.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.3 6.3 PID INSULIN PATHWAY Insulin Pathway
0.3 3.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 5.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.3 16.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.3 10.6 PID RHOA PATHWAY RhoA signaling pathway
0.3 16.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.3 11.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 20.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.3 10.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.3 7.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.3 4.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 9.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.3 8.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 11.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 3.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 11.6 PID E2F PATHWAY E2F transcription factor network
0.2 1.4 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.2 5.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 6.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 7.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 3.6 PID CONE PATHWAY Visual signal transduction: Cones
0.1 8.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 11.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 3.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 5.0 PID BMP PATHWAY BMP receptor signaling
0.1 3.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 3.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 20.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.3 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.8 PID P53 REGULATION PATHWAY p53 pathway
0.1 0.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.6 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 1.2 PID CDC42 PATHWAY CDC42 signaling events
0.0 9.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 151.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
4.6 68.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
4.5 67.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
4.3 99.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
4.3 170.3 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
2.7 32.9 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
2.6 60.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
2.5 227.6 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
2.5 17.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
2.3 43.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
2.2 20.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
2.2 165.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
2.2 17.5 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
2.2 41.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
2.1 31.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
2.0 41.8 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.8 22.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
1.7 225.0 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
1.7 51.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
1.7 144.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
1.6 42.7 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
1.5 30.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.4 19.9 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
1.4 40.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
1.3 27.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
1.2 14.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
1.2 8.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
1.2 23.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
1.2 56.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.1 35.7 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
1.1 13.0 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
1.0 9.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
1.0 14.5 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
1.0 86.0 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.9 33.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.9 88.1 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.9 19.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.9 15.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.9 11.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.9 6.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.8 27.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.8 14.8 REACTOME TRANSLATION Genes involved in Translation
0.8 27.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.8 22.2 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.8 11.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.7 20.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.7 12.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.7 16.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.6 6.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.5 10.3 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.5 17.2 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.5 41.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 10.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 9.6 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.4 21.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.4 8.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 16.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.4 12.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.4 7.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.4 9.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.4 4.9 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.3 4.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 2.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3 10.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 6.9 REACTOME KINESINS Genes involved in Kinesins
0.3 5.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 4.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 5.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 9.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 4.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 13.9 REACTOME AQUAPORIN MEDIATED TRANSPORT Genes involved in Aquaporin-mediated transport
0.3 9.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 21.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 6.5 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 17.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 5.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.2 5.1 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.2 3.8 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 4.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 3.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 6.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 4.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 4.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 14.0 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.2 4.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 6.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 4.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 3.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 1.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 2.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 5.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.1 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 5.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 4.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 9.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.7 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 1.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 3.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 2.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 2.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.0 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.1 3.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 2.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.8 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction