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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PITX2

Z-value: 1.47

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.17 PITX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg38_v1_chr4_-_110636963_110637042,
hg38_v1_chr4_-_110641920_110642123,
hg38_v1_chr4_-_110623051_110623085		-0.111.2e-01Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_35855627 10.13 ENST00000379893.5
DCLK1
doublecortin like kinase 1
chr11_-_5227063 8.16 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr13_-_35855758 5.97 ENST00000615680.4
DCLK1
doublecortin like kinase 1
chr11_-_133532493 5.14 ENST00000524381.6
OPCML
opioid binding protein/cell adhesion molecule like
chr4_-_101347492 4.90 ENST00000394854.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr4_-_101347327 4.52 ENST00000394853.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr3_+_159069252 4.14 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr4_-_101347471 3.98 ENST00000323055.10
ENST00000512215.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr4_-_101346842 3.98 ENST00000507176.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr12_-_89656051 3.51 ENST00000261173.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr12_-_89656093 3.42 ENST00000359142.7
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr16_-_11976611 2.49 ENST00000538896.5
ENST00000673243.1
NPIPB2
nuclear pore complex interacting protein family member B2
chrX_-_6228835 2.31 ENST00000381095.8
NLGN4X
neuroligin 4 X-linked
chr12_+_69739370 1.96 ENST00000550536.5
ENST00000362025.9
RAB3IP
RAB3A interacting protein
chr11_+_61755372 1.72 ENST00000265460.9
MYRF
myelin regulatory factor
chr12_-_118359639 1.56 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr10_-_60141004 1.50 ENST00000355288.6
ANK3
ankyrin 3
chr1_+_21977014 1.39 ENST00000337107.11
CELA3B
chymotrypsin like elastase 3B
chr14_+_75522531 1.37 ENST00000555504.1
BATF
basic leucine zipper ATF-like transcription factor
chr1_+_2476284 1.16 ENST00000378486.8
PLCH2
phospholipase C eta 2
chr1_-_30757767 0.97 ENST00000294507.4
LAPTM5
lysosomal protein transmembrane 5
chr1_+_2476315 0.91 ENST00000419816.6
PLCH2
phospholipase C eta 2
chr21_-_18403754 0.86 ENST00000284885.8
TMPRSS15
transmembrane serine protease 15
chr7_+_155458129 0.86 ENST00000297375.4
EN2
engrailed homeobox 2
chr15_-_89221558 0.59 ENST00000268125.10
RLBP1
retinaldehyde binding protein 1
chr12_+_7789393 0.54 ENST00000229307.9
NANOG
Nanog homeobox
chr6_+_35342535 0.53 ENST00000360694.8
ENST00000418635.6
ENST00000448077.6
PPARD
peroxisome proliferator activated receptor delta
chr1_+_22001654 0.44 ENST00000290122.8
CELA3A
chymotrypsin like elastase 3A
chrX_+_15749848 0.43 ENST00000479740.5
ENST00000454127.2
CA5B
carbonic anhydrase 5B
chr6_-_53148822 0.42 ENST00000259803.8
GCM1
glial cells missing transcription factor 1
chr19_+_2476118 0.33 ENST00000215631.9
ENST00000587345.1
GADD45B
growth arrest and DNA damage inducible beta
chr6_+_35342614 0.28 ENST00000337400.6
ENST00000311565.4
PPARD
peroxisome proliferator activated receptor delta
chr16_-_67980483 0.28 ENST00000268793.6
ENST00000672962.1
DPEP3
dipeptidase 3
chr1_-_165445220 0.25 ENST00000619224.1
RXRG
retinoid X receptor gamma
chr9_-_14300231 0.25 ENST00000636735.1
NFIB
nuclear factor I B
chr7_-_128775793 0.24 ENST00000249389.3
OPN1SW
opsin 1, short wave sensitive
chr5_-_150758497 0.23 ENST00000521533.1
ENST00000424236.5
DCTN4
dynactin subunit 4
chr3_+_154121366 0.20 ENST00000465093.6
ENST00000496710.5
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor 26
chr6_+_31137646 0.20 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr6_-_111483700 0.17 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr1_-_165445088 0.12 ENST00000359842.10
RXRG
retinoid X receptor gamma
chr1_+_202010575 0.09 ENST00000367283.7
ENST00000367284.10
ELF3
E74 like ETS transcription factor 3
chr9_+_34458752 0.08 ENST00000614641.4
ENST00000242317.9
ENST00000437363.5
DNAI1
dynein axonemal intermediate chain 1
chr9_+_12693327 0.05 ENST00000388918.10
TYRP1
tyrosinase related protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 17.4 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
2.7 8.2 GO:0030185 nitric oxide transport(GO:0030185)
1.2 6.9 GO:1990034 calcium ion export from cell(GO:1990034)
0.4 1.5 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 16.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 2.3 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.2 1.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.4 GO:0060018 astrocyte fate commitment(GO:0060018)
0.1 1.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 5.1 GO:0008038 neuron recognition(GO:0008038)
0.1 1.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 0.5 GO:0001714 endodermal cell fate specification(GO:0001714)
0.1 1.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.9 GO:1990403 embryonic brain development(GO:1990403)
0.0 2.1 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185) positive regulation of p38MAPK cascade(GO:1900745)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
1.6 17.4 GO:0005955 calcineurin complex(GO:0005955)
0.3 6.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.5 GO:0043194 spectrin-associated cytoskeleton(GO:0014731) axon initial segment(GO:0043194)
0.0 18.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 5.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 17.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
1.2 8.2 GO:0030492 hemoglobin binding(GO:0030492)
0.2 6.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 0.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 2.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 2.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 17.7 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 2.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 5.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 8.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway