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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PKNOX1_TGIF2

Z-value: 3.89

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Transcription factors associated with PKNOX1_TGIF2

Gene Symbol Gene ID Gene Info
PKNOX1
ENSG00000160199.15 PKNOX1
TGIF2
ENSG00000118707.11 TGIF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TGIF2hg38_v1_chr20_+_36574535_365746720.466.6e-13Click!
PKNOX1hg38_v1_chr21_+_42974510_42974649-0.212.1e-03Click!

Activity profile of PKNOX1_TGIF2 motif

Sorted Z-values of PKNOX1_TGIF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_148883474 17.87 ENST00000476773.5
EZH2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr18_+_3449620 17.23 ENST00000405385.7
TGIF1
TGFB induced factor homeobox 1
chr18_+_3449817 14.91 ENST00000407501.6
TGIF1
TGFB induced factor homeobox 1
chr6_+_110874775 14.13 ENST00000675380.1
ENST00000368882.8
ENST00000368877.9
ENST00000368885.8
ENST00000672937.2
AMD1
adenosylmethionine decarboxylase 1
chr18_+_3450036 13.58 ENST00000546979.5
ENST00000343820.10
ENST00000551402.1
ENST00000577543.5
TGIF1
TGFB induced factor homeobox 1
chr1_-_31919093 13.20 ENST00000602683.5
ENST00000470404.5
PTP4A2
protein tyrosine phosphatase 4A2
chr1_-_63523175 12.69 ENST00000371092.7
ENST00000271002.15
ITGB3BP
integrin subunit beta 3 binding protein
chr11_-_107858777 12.38 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr12_-_120581361 12.33 ENST00000341039.6
ENST00000357500.5
POP5
POP5 homolog, ribonuclease P/MRP subunit
chr2_+_218217131 11.85 ENST00000420104.5
ENST00000315717.10
ENST00000295685.14
ARPC2
actin related protein 2/3 complex subunit 2
chr10_+_28533706 11.75 ENST00000442148.6
ENST00000448193.5
WAC
WW domain containing adaptor with coiled-coil
chr3_-_33440343 11.73 ENST00000283629.8
UBP1
upstream binding protein 1
chr12_+_71754834 10.18 ENST00000261263.5
RAB21
RAB21, member RAS oncogene family
chr2_+_85577540 9.77 ENST00000263864.10
ENST00000409760.1
VAMP8
vesicle associated membrane protein 8
chr1_+_230067198 9.76 ENST00000366672.5
GALNT2
polypeptide N-acetylgalactosaminyltransferase 2
chr6_-_32173109 9.14 ENST00000395496.5
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr22_-_49825900 9.12 ENST00000404034.5
BRD1
bromodomain containing 1
chr18_-_56638427 8.79 ENST00000586262.5
ENST00000217515.11
TXNL1
thioredoxin like 1
chr17_-_81869934 8.21 ENST00000580685.5
ARHGDIA
Rho GDP dissociation inhibitor alpha
chr2_-_61538180 8.14 ENST00000677150.1
ENST00000678182.1
ENST00000677928.1
ENST00000406957.5
XPO1
exportin 1
chr2_-_61538313 7.90 ENST00000677803.1
ENST00000677239.1
ENST00000401558.7
XPO1
exportin 1
chr2_-_61538290 7.72 ENST00000678790.1
XPO1
exportin 1
chr14_+_103121457 7.36 ENST00000333007.8
TNFAIP2
TNF alpha induced protein 2
chr1_-_225427897 7.17 ENST00000421383.1
ENST00000272163.9
LBR
lamin B receptor
chr9_-_120842898 7.13 ENST00000625444.1
ENST00000210313.8
ENST00000373904.5
PSMD5
proteasome 26S subunit, non-ATPase 5
chr19_+_48993864 6.90 ENST00000595090.6
RUVBL2
RuvB like AAA ATPase 2
chr2_-_61538516 6.82 ENST00000676771.1
ENST00000677814.1
ENST00000443240.5
ENST00000677556.1
ENST00000676553.1
XPO1
exportin 1
chr18_+_3451585 6.65 ENST00000551541.5
TGIF1
TGFB induced factor homeobox 1
chr19_-_12933680 6.64 ENST00000593021.1
ENST00000314606.9
ENST00000587981.1
ENST00000423140.6
FARSA
phenylalanyl-tRNA synthetase subunit alpha
chr16_-_30445865 6.61 ENST00000478753.5
SEPHS2
selenophosphate synthetase 2
chr8_-_123396412 6.47 ENST00000287394.10
ATAD2
ATPase family AAA domain containing 2
chr14_+_93185304 6.35 ENST00000415050.3
TMEM251
transmembrane protein 251
chr1_+_23959797 6.30 ENST00000374468.1
ENST00000334351.8
PNRC2
proline rich nuclear receptor coactivator 2
chr17_-_31901658 6.23 ENST00000261708.9
UTP6
UTP6 small subunit processome component
chr18_+_3451647 6.05 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGIF1
TGFB induced factor homeobox 1
chr19_+_48993525 6.04 ENST00000601968.5
ENST00000596837.5
RUVBL2
RuvB like AAA ATPase 2
chr16_-_2980406 5.87 ENST00000431515.6
ENST00000574385.5
ENST00000576268.1
ENST00000574730.5
ENST00000262300.13
ENST00000575632.5
ENST00000573944.5
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr15_-_61229297 5.80 ENST00000335670.11
RORA
RAR related orphan receptor A
chr11_-_842508 5.78 ENST00000322028.5
POLR2L
RNA polymerase II, I and III subunit L
chr6_+_30328889 5.73 ENST00000396547.5
ENST00000623385.3
TRIM39
TRIM39-RPP21
tripartite motif containing 39
TRIM39-RPP21 readthrough
chr17_+_78378633 5.66 ENST00000262764.11
ENST00000589689.5
ENST00000592043.5
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr22_-_37244237 5.65 ENST00000401529.3
ENST00000249071.11
RAC2
Rac family small GTPase 2
chr3_-_3179674 5.47 ENST00000424814.5
ENST00000450014.1
ENST00000231948.9
ENST00000432408.6
ENST00000639284.1
CRBN
cereblon
chr1_-_70205531 5.46 ENST00000370952.4
LRRC40
leucine rich repeat containing 40
chr6_+_137867414 5.37 ENST00000237289.8
ENST00000433680.1
TNFAIP3
TNF alpha induced protein 3
chr12_-_31326111 5.33 ENST00000539409.5
SINHCAF
SIN3-HDAC complex associated factor
chr12_-_31326142 5.31 ENST00000337682.9
SINHCAF
SIN3-HDAC complex associated factor
chr9_-_127873462 5.23 ENST00000223836.10
AK1
adenylate kinase 1
chr1_+_109213887 5.06 ENST00000234677.7
ENST00000369923.4
SARS1
seryl-tRNA synthetase 1
chr11_+_74949241 4.97 ENST00000610881.4
ENST00000530257.5
ENST00000526361.1
ENST00000532972.5
ENST00000263672.11
SPCS2
signal peptidase complex subunit 2
chr10_+_68901258 4.95 ENST00000373585.8
DDX50
DExD-box helicase 50
chr1_+_207089233 4.94 ENST00000243611.9
ENST00000367076.7
C4BPB
complement component 4 binding protein beta
chr17_+_8288637 4.92 ENST00000407006.8
ENST00000226105.11
ENST00000580434.5
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chr6_-_100881281 4.87 ENST00000369143.2
ENST00000369162.7
ENST00000324723.10
ENST00000522650.5
ASCC3
activating signal cointegrator 1 complex subunit 3
chr13_-_46142834 4.74 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr1_+_207089195 4.73 ENST00000452902.6
C4BPB
complement component 4 binding protein beta
chr1_+_74235377 4.69 ENST00000326637.8
TNNI3K
TNNI3 interacting kinase
chr2_+_197515565 4.64 ENST00000233892.8
ENST00000409916.5
MOB4
MOB family member 4, phocein
chr8_-_116755784 4.60 ENST00000518949.5
ENST00000522453.1
ENST00000518995.5
ENST00000521861.6
ENST00000611080.1
EIF3H
eukaryotic translation initiation factor 3 subunit H
chr14_+_61697622 4.60 ENST00000539097.2
HIF1A
hypoxia inducible factor 1 subunit alpha
chr12_+_121888751 4.51 ENST00000261817.6
ENST00000538613.5
ENST00000542602.1
ENST00000541212.6
PSMD9
proteasome 26S subunit, non-ATPase 9
chr16_+_50742110 4.51 ENST00000566679.6
ENST00000564634.5
ENST00000398568.6
CYLD
CYLD lysine 63 deubiquitinase
chr7_-_23347704 4.49 ENST00000619562.4
IGF2BP3
insulin like growth factor 2 mRNA binding protein 3
chr16_-_57797764 4.47 ENST00000465878.6
ENST00000561524.5
KIFC3
kinesin family member C3
chr1_-_246566238 4.46 ENST00000366514.5
TFB2M
transcription factor B2, mitochondrial
chr1_+_207089283 4.43 ENST00000391923.1
C4BPB
complement component 4 binding protein beta
chr3_+_52794768 4.36 ENST00000621946.4
ENST00000416872.6
ENST00000449956.2
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr5_-_179624578 4.33 ENST00000505811.5
ENST00000515714.5
ENST00000513225.5
ENST00000503664.1
ENST00000356731.9
ENST00000523137.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr22_-_37244417 4.28 ENST00000405484.5
ENST00000441619.5
ENST00000406508.5
RAC2
Rac family small GTPase 2
chr8_+_11809135 4.01 ENST00000528643.5
ENST00000525777.5
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr10_-_46030585 4.01 ENST00000580070.5
ENST00000578454.5
ENST00000585056.5
ENST00000579039.2
ENST00000581486.6
NCOA4
nuclear receptor coactivator 4
chr9_-_128191878 3.97 ENST00000538431.5
CIZ1
CDKN1A interacting zinc finger protein 1
chr16_+_50742037 3.93 ENST00000569418.5
CYLD
CYLD lysine 63 deubiquitinase
chr1_-_50960230 3.92 ENST00000396153.7
FAF1
Fas associated factor 1
chr14_-_100376251 3.91 ENST00000556645.5
ENST00000556209.5
ENST00000556504.5
ENST00000556435.5
ENST00000554772.5
ENST00000553581.1
ENST00000553769.6
ENST00000554605.5
ENST00000557722.5
ENST00000553413.5
ENST00000553524.5
ENST00000358655.8
WARS1
tryptophanyl-tRNA synthetase 1
chr1_+_207088825 3.90 ENST00000367078.8
C4BPB
complement component 4 binding protein beta
chr4_+_56907876 3.89 ENST00000640168.2
ENST00000309042.12
REST
RE1 silencing transcription factor
chr15_+_68054308 3.75 ENST00000249636.11
PIAS1
protein inhibitor of activated STAT 1
chr3_-_52535006 3.72 ENST00000307076.8
NT5DC2
5'-nucleotidase domain containing 2
chr5_-_181239571 3.69 ENST00000509535.5
RACK1
receptor for activated C kinase 1
chr2_+_99337364 3.64 ENST00000617677.1
ENST00000289371.11
EIF5B
eukaryotic translation initiation factor 5B
chr12_+_12891554 3.61 ENST00000014914.6
GPRC5A
G protein-coupled receptor class C group 5 member A
chr12_-_6851245 3.54 ENST00000540683.1
ENST00000229265.10
ENST00000535406.5
ENST00000422785.7
ENST00000538862.7
CDCA3
cell division cycle associated 3
chr6_+_31706866 3.45 ENST00000375832.5
ENST00000503322.1
LY6G6F
LY6G6F-LY6G6D
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr12_+_62260374 3.38 ENST00000312635.10
ENST00000280377.10
ENST00000549237.5
USP15
ubiquitin specific peptidase 15
chr1_-_33036927 3.38 ENST00000354858.11
AK2
adenylate kinase 2
chr3_+_184174846 3.32 ENST00000427072.5
ENST00000411763.6
ENST00000292807.9
ENST00000448139.5
ENST00000455925.1
AP2M1
adaptor related protein complex 2 subunit mu 1
chr1_-_154627576 3.30 ENST00000648311.1
ADAR
adenosine deaminase RNA specific
chr6_+_137867241 3.25 ENST00000612899.5
ENST00000420009.5
TNFAIP3
TNF alpha induced protein 3
chr16_+_30201057 3.23 ENST00000569485.5
SULT1A3
sulfotransferase family 1A member 3
chr3_+_37975773 3.09 ENST00000436654.1
CTDSPL
CTD small phosphatase like
chr3_+_111542178 3.02 ENST00000283285.10
ENST00000352690.9
CD96
CD96 molecule
chr5_+_43603163 2.97 ENST00000660752.1
ENST00000654405.1
ENST00000344920.9
ENST00000657172.1
ENST00000512996.6
ENST00000671668.1
NNT
nicotinamide nucleotide transhydrogenase
chr16_-_20806431 2.96 ENST00000357967.9
ENST00000300005.7
ENST00000569729.5
ERI2
ERI1 exoribonuclease family member 2
chr9_-_97697297 2.91 ENST00000375128.5
XPA
XPA, DNA damage recognition and repair factor
chr11_-_46846233 2.88 ENST00000529230.6
ENST00000312055.9
CKAP5
cytoskeleton associated protein 5
chr7_-_105269007 2.88 ENST00000357311.7
SRPK2
SRSF protein kinase 2
chr4_+_109815503 2.76 ENST00000394631.7
GAR1
GAR1 ribonucleoprotein
chr7_+_74453790 2.69 ENST00000265755.7
ENST00000424337.7
ENST00000455841.6
GTF2IRD1
GTF2I repeat domain containing 1
chr2_+_222860942 2.66 ENST00000392066.7
ENST00000680251.1
ENST00000679541.1
ENST00000679545.1
ENST00000680395.1
ACSL3
acyl-CoA synthetase long chain family member 3
chr1_-_33036840 2.65 ENST00000548033.5
ENST00000487289.1
ENST00000626911.1
ENST00000673291.1
ENST00000480134.5
ENST00000373449.7
ENST00000672715.1
ENST00000467905.5
ENST00000629371.2
AK2
adenylate kinase 2
chr5_-_170297746 2.64 ENST00000046794.10
LCP2
lymphocyte cytosolic protein 2
chr1_+_145719468 2.64 ENST00000616463.1
CD160
CD160 molecule
chr4_+_8182066 2.62 ENST00000508641.2
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr6_-_41705813 2.54 ENST00000419574.6
ENST00000445214.2
TFEB
transcription factor EB
chr8_+_96493803 2.45 ENST00000518385.5
ENST00000302190.9
SDC2
syndecan 2
chr19_+_9827886 2.45 ENST00000358666.7
ENST00000590068.1
ENST00000593087.1
ENST00000586895.6
UBL5
ubiquitin like 5
chr15_+_76931704 2.38 ENST00000320963.9
ENST00000394885.8
ENST00000394883.3
RCN2
reticulocalbin 2
chr7_+_95485898 2.36 ENST00000428113.5
ASB4
ankyrin repeat and SOCS box containing 4
chr12_-_112409550 2.35 ENST00000550566.6
ENST00000553213.2
ENST00000424576.6
ENST00000202773.14
RPL6
ribosomal protein L6
chr1_+_145719483 2.33 ENST00000369288.7
CD160
CD160 molecule
chr11_-_111871271 2.24 ENST00000398006.6
ALG9
ALG9 alpha-1,2-mannosyltransferase
chr1_+_154993581 2.24 ENST00000392487.1
LENEP
lens epithelial protein
chr12_-_30735014 2.19 ENST00000433722.6
CAPRIN2
caprin family member 2
chr4_-_47837949 2.19 ENST00000505909.5
ENST00000273857.9
ENST00000502252.5
CORIN
corin, serine peptidase
chr2_-_202238558 2.17 ENST00000392244.7
ENST00000409181.1
ENST00000409712.5
ENST00000409498.6
ENST00000409368.5
ENST00000392246.7
ENST00000392245.5
SUMO1
small ubiquitin like modifier 1
chr1_-_209651291 2.15 ENST00000391911.5
ENST00000415782.1
LAMB3
laminin subunit beta 3
chr22_+_25219633 2.08 ENST00000398215.3
CRYBB2
crystallin beta B2
chr21_+_29130630 2.07 ENST00000399926.5
ENST00000399928.6
MAP3K7CL
MAP3K7 C-terminal like
chr6_+_149749695 2.07 ENST00000367380.9
ENST00000544496.5
ENST00000649295.1
ENST00000464889.7
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr8_+_28316979 2.05 ENST00000518479.5
PNOC
prepronociceptin
chr19_-_12401247 2.04 ENST00000595766.1
ENST00000430385.3
ENST00000435033.1
ZNF799
ENSG00000268744.1
zinc finger protein 799
novel transcript
chr1_-_35193135 2.04 ENST00000357214.6
SFPQ
splicing factor proline and glutamine rich
chr10_-_11532275 2.01 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr9_-_33447553 2.00 ENST00000645858.1
ENST00000297991.6
AQP3
aquaporin 3 (Gill blood group)
chr6_+_26124161 2.00 ENST00000377791.4
ENST00000602637.1
H2AC6
H2A clustered histone 6
chr14_-_105168753 1.94 ENST00000331782.8
ENST00000347004.2
JAG2
jagged canonical Notch ligand 2
chr3_-_97972087 1.92 ENST00000360258.8
RIOX2
ribosomal oxygenase 2
chr2_+_222861005 1.92 ENST00000680147.1
ENST00000681009.1
ENST00000679514.1
ENST00000357430.8
ACSL3
acyl-CoA synthetase long chain family member 3
chr12_-_91004965 1.91 ENST00000261172.8
EPYC
epiphycan
chr5_+_142771119 1.87 ENST00000642734.1
ARHGAP26
Rho GTPase activating protein 26
chr9_+_4839761 1.85 ENST00000448872.6
ENST00000441844.2
RCL1
RNA terminal phosphate cyclase like 1
chr19_+_48872412 1.84 ENST00000200453.6
PPP1R15A
protein phosphatase 1 regulatory subunit 15A
chr4_-_47838095 1.80 ENST00000610355.4
ENST00000504584.1
CORIN
corin, serine peptidase
chr19_-_48993300 1.80 ENST00000323798.8
ENST00000263276.6
GYS1
glycogen synthase 1
chr7_+_76510528 1.79 ENST00000334348.8
UPK3B
uroplakin 3B
chr8_-_98825628 1.75 ENST00000617590.1
ENST00000518165.5
ENST00000419617.7
STK3
serine/threonine kinase 3
chr7_+_100373458 1.74 ENST00000453419.5
ENST00000198536.7
ENST00000394000.6
ENST00000350573.2
PILRA
paired immunoglobin like type 2 receptor alpha
chr19_-_49580542 1.74 ENST00000596358.6
ENST00000339093.7
NOSIP
nitric oxide synthase interacting protein
chr3_-_155806260 1.73 ENST00000534941.2
ENST00000340171.7
C3orf33
chromosome 3 open reading frame 33
chr12_+_75391078 1.71 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1L2
GLIPR1 like 2
chr4_+_8229170 1.70 ENST00000511002.6
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr3_+_12287962 1.65 ENST00000643197.2
ENST00000644622.2
PPARG
peroxisome proliferator activated receptor gamma
chr7_+_92057602 1.57 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr8_+_23288081 1.56 ENST00000265806.12
ENST00000519952.6
ENST00000518840.6
R3HCC1
R3H domain and coiled-coil containing 1
chr7_-_5528029 1.56 ENST00000464611.1
ACTB
actin beta
chr6_-_31684040 1.53 ENST00000375863.7
LY6G5C
lymphocyte antigen 6 family member G5C
chr3_-_113441487 1.52 ENST00000393845.9
ENST00000295868.6
CFAP44
cilia and flagella associated protein 44
chr16_+_16390834 1.47 ENST00000344087.4
NPIPA7
nuclear pore complex interacting protein family member A7
chr2_+_233060295 1.46 ENST00000445964.6
INPP5D
inositol polyphosphate-5-phosphatase D
chr5_-_53109733 1.41 ENST00000510818.6
ENST00000396954.8
ENST00000450852.8
ENST00000508922.5
ENST00000361377.8
ENST00000582677.5
ENST00000584946.5
MOCS2
molybdenum cofactor synthesis 2
chr1_+_161766282 1.37 ENST00000680688.1
ATF6
activating transcription factor 6
chrX_+_136648138 1.35 ENST00000370629.7
CD40LG
CD40 ligand
chr6_+_138773747 1.32 ENST00000617445.5
CCDC28A
coiled-coil domain containing 28A
chr22_-_29838227 1.28 ENST00000307790.8
ENST00000397771.6
ENST00000542393.5
ASCC2
activating signal cointegrator 1 complex subunit 2
chr3_+_45594727 1.25 ENST00000273317.5
LIMD1
LIM domains containing 1
chr7_+_76510516 1.22 ENST00000257632.9
UPK3B
uroplakin 3B
chr15_+_49621004 1.21 ENST00000403028.8
ENST00000558653.5
ENST00000559164.5
ENST00000560632.5
ENST00000559405.5
ENST00000251250.7
DTWD1
DTW domain containing 1
chr14_-_94390650 1.20 ENST00000449399.7
ENST00000404814.8
SERPINA1
serpin family A member 1
chr14_-_94390614 1.19 ENST00000553327.5
ENST00000556955.5
ENST00000557118.5
ENST00000440909.5
SERPINA1
serpin family A member 1
chr2_-_191150971 1.17 ENST00000409995.5
ENST00000392320.7
STAT4
signal transducer and activator of transcription 4
chr19_+_10718047 1.16 ENST00000585892.5
ENST00000355667.11
ENST00000389253.9
ENST00000359692.10
DNM2
dynamin 2
chr12_-_70609788 1.16 ENST00000547715.1
ENST00000538708.5
ENST00000550857.5
ENST00000261266.9
PTPRB
protein tyrosine phosphatase receptor type B
chr16_+_27402167 1.13 ENST00000564089.5
ENST00000337929.8
IL21R
interleukin 21 receptor
chr14_-_94390667 1.13 ENST00000557492.5
ENST00000355814.8
ENST00000437397.5
ENST00000448921.5
ENST00000393088.8
SERPINA1
serpin family A member 1
chr20_-_37527891 1.07 ENST00000414542.6
BLCAP
BLCAP apoptosis inducing factor
chr22_+_38656627 1.06 ENST00000411557.5
ENST00000396811.6
ENST00000216029.7
ENST00000416285.5
CBY1
chibby family member 1, beta catenin antagonist
chr4_-_174522315 1.06 ENST00000514584.5
HPGD
15-hydroxyprostaglandin dehydrogenase
chr2_+_200308943 1.00 ENST00000619961.4
SPATS2L
spermatogenesis associated serine rich 2 like
chr2_+_105851748 0.94 ENST00000425756.1
ENST00000393349.2
NCK2
NCK adaptor protein 2
chr13_-_41263484 0.94 ENST00000379477.5
ENST00000452359.5
ENST00000379480.9
ENST00000430347.3
MTRF1
mitochondrial translation release factor 1
chr19_+_7669080 0.93 ENST00000629642.1
RETN
resistin
chrX_+_136648214 0.90 ENST00000370628.2
CD40LG
CD40 ligand
chr3_+_12287899 0.87 ENST00000643888.2
PPARG
peroxisome proliferator activated receptor gamma
chr11_-_36289408 0.86 ENST00000263401.10
ENST00000532705.1
ENST00000452374.6
COMMD9
COMM domain containing 9
chr2_-_202238462 0.82 ENST00000409205.5
SUMO1
small ubiquitin like modifier 1
chr20_-_37527862 0.82 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP
BLCAP apoptosis inducing factor
chr19_-_6424802 0.79 ENST00000600480.2
KHSRP
KH-type splicing regulatory protein
chr17_-_37609361 0.79 ENST00000614941.4
ENST00000619541.4
ENST00000622045.4
ENST00000616179.4
ENST00000621136.4
ENST00000612223.5
ENST00000620424.1
SYNRG
synergin gamma
chr17_+_70075215 0.75 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr2_-_224947030 0.75 ENST00000409592.7
DOCK10
dedicator of cytokinesis 10
chr21_-_32813679 0.73 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr12_-_104138007 0.72 ENST00000551727.5
NFYB
nuclear transcription factor Y subunit beta
chr3_-_49786508 0.62 ENST00000395238.5
ENST00000468463.5
ENST00000321599.9
ENST00000460540.1
IP6K1
inositol hexakisphosphate kinase 1
chr14_+_61529005 0.61 ENST00000556347.1
ENSG00000258989.1
novel protein
chr17_+_70075317 0.60 ENST00000589377.1
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr2_+_10420021 0.60 ENST00000422133.1
HPCAL1
hippocalcin like 1
chr1_-_12616762 0.59 ENST00000464917.5
DHRS3
dehydrogenase/reductase 3
chr16_-_4846196 0.58 ENST00000589389.5
GLYR1
glyoxylate reductase 1 homolog
chr14_-_21526391 0.57 ENST00000611430.4
SALL2
spalt like transcription factor 2
chr11_-_64284639 0.55 ENST00000394532.7
ENST00000394531.3
ENST00000309032.8
BAD
BCL2 associated agonist of cell death
chr3_+_50246888 0.54 ENST00000451956.1
GNAI2
G protein subunit alpha i2
chr2_-_182242031 0.53 ENST00000358139.6
PDE1A
phosphodiesterase 1A
chr4_+_168497066 0.51 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr7_+_129375643 0.49 ENST00000490911.5
AHCYL2
adenosylhomocysteinase like 2
chr16_-_30370396 0.48 ENST00000409939.8
TBC1D10B
TBC1 domain family member 10B
chr2_+_233760265 0.44 ENST00000305208.10
ENST00000360418.4
UGT1A1
UDP glucuronosyltransferase family 1 member A1
chr17_-_41481140 0.44 ENST00000246639.6
ENST00000393989.1
KRT35
keratin 35
chr7_+_66740725 0.43 ENST00000442563.5
ENST00000450873.6
ENST00000284957.9
RABGEF1
RAB guanine nucleotide exchange factor 1
chr19_-_51034727 0.43 ENST00000525263.5
KLK12
kallikrein related peptidase 12

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 17.9 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
3.9 11.6 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
3.3 9.8 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
3.3 9.8 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
3.2 12.9 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
2.9 8.6 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
2.8 30.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
2.4 11.8 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
2.3 18.0 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
2.0 14.1 GO:0008295 spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295)
2.0 6.0 GO:0006172 ADP biosynthetic process(GO:0006172)
1.6 4.9 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
1.5 4.5 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
1.4 12.3 GO:0009249 protein lipoylation(GO:0009249)
1.3 6.6 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.3 3.9 GO:0097086 amniotic stem cell differentiation(GO:0097086) negative regulation of dense core granule biogenesis(GO:2000706) negative regulation of mesenchymal stem cell differentiation(GO:2000740) regulation of amniotic stem cell differentiation(GO:2000797) negative regulation of amniotic stem cell differentiation(GO:2000798)
1.3 3.8 GO:1990108 protein linear deubiquitination(GO:1990108)
1.1 4.6 GO:0001922 B-1 B cell homeostasis(GO:0001922)
1.1 4.6 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
1.1 5.7 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
1.1 4.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.9 2.8 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.9 9.9 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.8 6.6 GO:0001887 selenium compound metabolic process(GO:0001887)
0.8 6.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.8 3.0 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.7 7.4 GO:0051601 exocyst localization(GO:0051601)
0.7 10.2 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.7 6.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.7 4.0 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.7 9.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.6 1.8 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.6 3.0 GO:0006740 NADPH regeneration(GO:0006740)
0.6 6.5 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.6 3.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.6 3.3 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.5 2.7 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.5 3.2 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.5 12.2 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.5 3.7 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.5 1.6 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.5 2.0 GO:0070295 renal water absorption(GO:0070295)
0.5 1.9 GO:0030961 peptidyl-arginine hydroxylation(GO:0030961)
0.5 2.9 GO:0035063 nuclear speck organization(GO:0035063)
0.4 3.0 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.4 5.8 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.4 1.5 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.4 2.5 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.4 12.7 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 1.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 2.0 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.3 5.5 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.3 3.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.3 4.7 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.3 5.7 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.3 3.7 GO:0033235 positive regulation of protein sumoylation(GO:0033235) positive regulation of smooth muscle cell differentiation(GO:0051152)
0.3 4.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 2.1 GO:0030091 protein repair(GO:0030091)
0.2 3.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 1.8 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.2 7.9 GO:0035902 response to immobilization stress(GO:0035902)
0.2 7.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.2 1.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 1.6 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.2 1.4 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.2 6.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 1.1 GO:0008218 bioluminescence(GO:0008218)
0.2 1.9 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.2 1.4 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.2 5.0 GO:0006465 signal peptide processing(GO:0006465)
0.2 0.9 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.2 2.0 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.2 2.9 GO:0070914 UV-damage excision repair(GO:0070914)
0.2 0.6 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.2 5.8 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.2 3.3 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.1 2.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.4 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.1 1.7 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 1.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 2.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 2.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.6 GO:0044533 induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501)
0.1 0.4 GO:0018879 biphenyl metabolic process(GO:0018879)
0.1 5.2 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.1 13.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 8.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 4.0 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 1.5 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.1 2.2 GO:0035812 renal sodium excretion(GO:0035812) regulation of renal sodium excretion(GO:0035813)
0.1 5.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.2 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.1 45.9 GO:0042493 response to drug(GO:0042493)
0.1 2.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.5 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.1 0.9 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 2.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 5.9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 3.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.4 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 3.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 2.5 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 0.2 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 2.5 GO:0006953 acute-phase response(GO:0006953)
0.0 0.5 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 3.8 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 0.0 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.5 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 1.7 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 2.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.1 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 0.3 GO:0015816 glycine transport(GO:0015816)
0.0 4.3 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 4.7 GO:0019079 viral genome replication(GO:0019079)
0.0 2.5 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.0 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 1.8 GO:0032092 positive regulation of protein binding(GO:0032092)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 1.2 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349)
0.0 0.3 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.9 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 1.1 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.2 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 1.1 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
2.2 6.6 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
2.1 12.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.9 30.6 GO:0005642 annulate lamellae(GO:0005642)
1.3 12.9 GO:0097255 R2TP complex(GO:0097255)
1.3 10.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
1.2 6.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
1.1 17.9 GO:0045120 pronucleus(GO:0045120)
0.8 9.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.7 3.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.7 11.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.6 5.0 GO:0005787 signal peptidase complex(GO:0005787)
0.5 2.6 GO:0036398 TCR signalosome(GO:0036398)
0.5 3.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.5 4.6 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.5 5.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.4 7.4 GO:0000145 exocyst(GO:0000145)
0.4 3.7 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.4 4.0 GO:0044754 autolysosome(GO:0044754)
0.4 2.8 GO:0072589 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.4 1.6 GO:0044307 dendritic branch(GO:0044307)
0.4 2.9 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.4 5.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 4.5 GO:0005915 zonula adherens(GO:0005915)
0.3 2.1 GO:0005610 laminin-5 complex(GO:0005610)
0.3 6.3 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.3 2.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 5.1 GO:0001891 phagocytic cup(GO:0001891)
0.3 9.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 3.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 2.0 GO:0042382 paraspeckles(GO:0042382)
0.2 17.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 0.4 GO:0070069 cytochrome complex(GO:0070069)
0.2 3.3 GO:0036020 endolysosome membrane(GO:0036020)
0.2 15.5 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 16.1 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1 5.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 8.8 GO:0000502 proteasome complex(GO:0000502)
0.1 1.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.6 GO:0097433 dense body(GO:0097433)
0.1 3.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 4.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 4.8 GO:1904115 axon cytoplasm(GO:1904115)
0.1 1.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 1.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.6 GO:0000786 nucleosome(GO:0000786)
0.1 4.6 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 4.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 4.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 10.6 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.0 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 3.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.9 GO:0016605 PML body(GO:0016605)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 8.0 GO:0005769 early endosome(GO:0005769)
0.0 82.4 GO:0005654 nucleoplasm(GO:0005654)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.2 GO:0070821 tertiary granule membrane(GO:0070821)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 12.9 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
2.4 7.2 GO:0050613 delta14-sterol reductase activity(GO:0050613)
2.0 30.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
1.9 58.4 GO:0070410 co-SMAD binding(GO:0070410)
1.8 17.9 GO:0070878 primary miRNA binding(GO:0070878)
1.5 13.2 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
1.5 8.8 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.3 6.6 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.0 12.3 GO:0004526 ribonuclease P activity(GO:0004526)
1.0 8.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.9 12.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.8 9.8 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.8 3.2 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.8 11.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.7 2.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.7 4.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.7 9.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.7 4.0 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.7 3.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.6 5.7 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.6 3.7 GO:0061665 SUMO ligase activity(GO:0061665)
0.6 4.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.6 4.9 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.6 2.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.5 1.6 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.5 8.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.5 2.0 GO:0015254 glycerol channel activity(GO:0015254)
0.5 4.7 GO:0031013 troponin I binding(GO:0031013)
0.5 1.8 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.4 2.1 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.4 3.3 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.4 2.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.4 11.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.4 3.7 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.4 1.5 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.4 5.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 9.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 1.0 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.3 5.0 GO:0032393 MHC class I receptor activity(GO:0032393)
0.3 3.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 4.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.3 2.5 GO:0050692 DBD domain binding(GO:0050692)
0.2 14.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 2.4 GO:0031386 protein tag(GO:0031386)
0.2 6.2 GO:0030515 snoRNA binding(GO:0030515)
0.2 0.6 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 4.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 3.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 1.8 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 1.9 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 3.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 4.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.9 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 4.6 GO:0070888 E-box binding(GO:0070888)
0.1 10.1 GO:0019003 GDP binding(GO:0019003)
0.1 8.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 4.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.9 GO:0005112 Notch binding(GO:0005112)
0.1 1.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.4 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 3.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.7 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.8 GO:0005536 glucose binding(GO:0005536)
0.1 4.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 3.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.4 GO:0035497 cAMP response element binding(GO:0035497)
0.1 5.0 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.7 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 2.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 4.2 GO:0050681 androgen receptor binding(GO:0050681)
0.1 6.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 12.5 GO:0042393 histone binding(GO:0042393)
0.1 1.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 12.6 GO:0051015 actin filament binding(GO:0051015)
0.0 1.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 12.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 5.5 GO:0000149 SNARE binding(GO:0000149)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 3.0 GO:0050661 NADP binding(GO:0050661)
0.0 10.1 GO:0003924 GTPase activity(GO:0003924)
0.0 1.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 2.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 8.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.1 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 2.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.0 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 5.0 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 37.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.5 62.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 13.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 21.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.3 12.9 PID MYC PATHWAY C-MYC pathway
0.3 11.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 20.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 4.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 2.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 5.6 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.3 PID ARF 3PATHWAY Arf1 pathway
0.1 3.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 6.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 9.8 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 2.2 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.9 PID AURORA A PATHWAY Aurora A signaling
0.1 2.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 1.5 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 1.5 PID IGF1 PATHWAY IGF1 pathway
0.1 6.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.1 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.9 PID P73PATHWAY p73 transcription factor network
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 36.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.1 58.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.8 12.7 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.7 6.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.7 14.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.6 15.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.5 1.9 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.3 11.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 12.9 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.3 6.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.3 4.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3 9.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.3 11.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 12.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 5.0 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3 5.8 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 9.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 10.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 3.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 9.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 5.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 11.6 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 2.0 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.9 REACTOME GLOBAL GENOMIC NER GG NER Genes involved in Global Genomic NER (GG-NER)
0.1 3.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 10.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 5.7 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 2.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 1.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 6.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 0.9 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 4.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 1.7 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 3.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 6.0 REACTOME TRANSLATION Genes involved in Translation
0.0 2.4 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 2.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 4.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 2.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 3.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 1.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.5 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events