Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PKNOX2

Z-value: 1.15

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
PKNOX2
ENSG00000165495.16 PKNOX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PKNOX2hg38_v1_chr11_+_125164743_1251647590.082.6e-01Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_109094819 3.83 ENST00000436639.6
SESN1
sestrin 1
chr6_-_87095059 3.29 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr7_-_137343688 3.22 ENST00000348225.7
PTN
pleiotrophin
chr5_+_126423176 3.20 ENST00000542322.5
ENST00000544396.5
GRAMD2B
GRAM domain containing 2B
chr5_+_126423363 3.20 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B
chr5_+_126423122 3.20 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chr6_+_17600273 3.17 ENST00000259963.4
FAM8A1
family with sequence similarity 8 member A1
chr18_+_56651385 2.97 ENST00000615645.4
WDR7
WD repeat domain 7
chr6_-_83709019 2.89 ENST00000519779.5
ENST00000369694.6
ENST00000195649.10
SNAP91
synaptosome associated protein 91
chr18_+_56651335 2.85 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chrX_+_102125703 2.59 ENST00000329035.2
TCEAL2
transcription elongation factor A like 2
chr14_-_21526312 2.58 ENST00000537235.2
SALL2
spalt like transcription factor 2
chrX_+_102125668 2.57 ENST00000372780.6
TCEAL2
transcription elongation factor A like 2
chr15_+_32718476 2.47 ENST00000652365.1
GREM1
gremlin 1, DAN family BMP antagonist
chr2_+_232378743 2.40 ENST00000392027.3
ALPP
alkaline phosphatase, placental
chr4_+_113116676 2.29 ENST00000671971.1
ENST00000672240.1
ENST00000673240.1
ENST00000673363.1
ANK2
ankyrin 2
chr14_-_21024092 2.26 ENST00000554398.5
NDRG2
NDRG family member 2
chr14_-_21023954 2.26 ENST00000554094.5
NDRG2
NDRG family member 2
chr11_+_12110569 2.24 ENST00000683283.1
ENST00000256194.8
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr11_-_31804067 2.22 ENST00000639548.1
ENST00000640125.1
ENST00000481563.6
ENST00000639079.1
ENST00000638762.1
ENST00000638346.1
PAX6
paired box 6
chr2_-_210315160 2.22 ENST00000352451.4
MYL1
myosin light chain 1
chr6_-_116254063 2.21 ENST00000420283.3
TSPYL4
TSPY like 4
chr11_-_31803960 2.09 ENST00000640872.1
ENST00000639109.1
ENST00000638629.1
ENST00000639386.2
PAX6
paired box 6
chr7_-_137343752 2.06 ENST00000393083.2
PTN
pleiotrophin
chr15_+_32717994 2.01 ENST00000560677.5
ENST00000560830.1
ENST00000651154.1
GREM1
gremlin 1, DAN family BMP antagonist
chr9_+_129835442 2.00 ENST00000372429.8
ENST00000315480.9
ENST00000358355.5
USP20
ubiquitin specific peptidase 20
chr8_+_96493803 2.00 ENST00000518385.5
ENST00000302190.9
SDC2
syndecan 2
chr16_-_53503192 1.99 ENST00000568596.5
ENST00000394657.12
ENST00000570004.5
ENST00000564497.1
ENST00000300245.8
AKTIP
AKT interacting protein
chr9_-_76692181 1.88 ENST00000376717.6
ENST00000223609.10
PRUNE2
prune homolog 2 with BCH domain
chr21_-_31558977 1.86 ENST00000286827.7
ENST00000541036.5
TIAM1
TIAM Rac1 associated GEF 1
chr2_-_178807415 1.78 ENST00000342992.10
ENST00000460472.6
ENST00000589042.5
ENST00000591111.5
ENST00000360870.10
TTN
titin
chr3_-_127822835 1.76 ENST00000453507.6
MGLL
monoglyceride lipase
chr16_+_50742059 1.75 ENST00000311559.13
ENST00000564326.5
ENST00000566206.5
ENST00000427738.8
CYLD
CYLD lysine 63 deubiquitinase
chr11_-_59615673 1.70 ENST00000263847.6
OSBP
oxysterol binding protein
chr1_-_12616762 1.70 ENST00000464917.5
DHRS3
dehydrogenase/reductase 3
chr9_+_95875671 1.56 ENST00000683991.1
ENST00000683350.1
ENST00000653738.2
ENST00000288985.12
ENST00000665077.3
ERCC6L2
ERCC excision repair 6 like 2
chr12_-_121296685 1.50 ENST00000412367.6
ENST00000404169.8
ENST00000402834.8
CAMKK2
calcium/calmodulin dependent protein kinase kinase 2
chr6_+_26124161 1.50 ENST00000377791.4
ENST00000602637.1
H2AC6
H2A clustered histone 6
chr1_+_100133135 1.44 ENST00000370143.5
ENST00000370141.7
TRMT13
tRNA methyltransferase 13 homolog
chr5_-_128538230 1.41 ENST00000262464.9
FBN2
fibrillin 2
chr7_-_100656384 1.38 ENST00000461605.1
ENST00000160382.10
ACTL6B
actin like 6B
chr3_-_127822455 1.38 ENST00000265052.10
MGLL
monoglyceride lipase
chr16_+_1706163 1.37 ENST00000250894.8
ENST00000673691.1
ENST00000356010.9
ENST00000610761.2
MAPK8IP3
mitogen-activated protein kinase 8 interacting protein 3
chr5_+_119071050 1.37 ENST00000539542.6
DMXL1
Dmx like 1
chr12_-_121296669 1.36 ENST00000652382.1
CAMKK2
calcium/calmodulin dependent protein kinase kinase 2
chr16_+_50742037 1.33 ENST00000569418.5
CYLD
CYLD lysine 63 deubiquitinase
chr3_-_3179674 1.23 ENST00000424814.5
ENST00000450014.1
ENST00000231948.9
ENST00000432408.6
ENST00000639284.1
CRBN
cereblon
chr12_+_62260374 1.22 ENST00000312635.10
ENST00000280377.10
ENST00000549237.5
USP15
ubiquitin specific peptidase 15
chr22_+_23772839 1.22 ENST00000215743.8
MMP11
matrix metallopeptidase 11
chr16_+_50742110 1.21 ENST00000566679.6
ENST00000564634.5
ENST00000398568.6
CYLD
CYLD lysine 63 deubiquitinase
chr20_-_3084716 1.15 ENST00000380293.3
AVP
arginine vasopressin
chr17_+_4143168 1.14 ENST00000577075.6
ENST00000301391.8
ENST00000575251.5
CYB5D2
cytochrome b5 domain containing 2
chr2_+_128091166 1.11 ENST00000259253.11
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr19_-_45322867 1.07 ENST00000221476.4
CKM
creatine kinase, M-type
chr19_-_10010492 1.01 ENST00000264828.4
COL5A3
collagen type V alpha 3 chain
chr12_+_62260338 0.97 ENST00000353364.7
ENST00000549523.5
USP15
ubiquitin specific peptidase 15
chr6_+_137867414 0.97 ENST00000237289.8
ENST00000433680.1
TNFAIP3
TNF alpha induced protein 3
chr2_+_232406836 0.96 ENST00000295453.8
ALPG
alkaline phosphatase, germ cell
chr4_-_148444674 0.96 ENST00000344721.8
NR3C2
nuclear receptor subfamily 3 group C member 2
chr10_+_68901258 0.95 ENST00000373585.8
DDX50
DExD-box helicase 50
chr19_-_5622768 0.93 ENST00000252542.9
SAFB2
scaffold attachment factor B2
chr17_-_42185452 0.90 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr17_+_70075317 0.88 ENST00000589377.1
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr20_-_37527862 0.87 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP
BLCAP apoptosis inducing factor
chr19_+_10718114 0.87 ENST00000408974.8
DNM2
dynamin 2
chr17_+_70075215 0.83 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr11_+_6390439 0.82 ENST00000530395.1
ENST00000342245.9
ENST00000527275.5
SMPD1
sphingomyelin phosphodiesterase 1
chr22_-_50507678 0.80 ENST00000216080.5
ENST00000474879.7
LMF2
lipase maturation factor 2
chr16_+_2537997 0.78 ENST00000441549.7
ENST00000268673.11
ENST00000342085.9
ENST00000389224.7
PDPK1
3-phosphoinositide dependent protein kinase 1
chr6_+_137867241 0.75 ENST00000612899.5
ENST00000420009.5
TNFAIP3
TNF alpha induced protein 3
chr5_+_119071358 0.75 ENST00000311085.8
DMXL1
Dmx like 1
chr14_-_21526391 0.74 ENST00000611430.4
SALL2
spalt like transcription factor 2
chr4_+_168497044 0.69 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr17_-_29078857 0.68 ENST00000359450.6
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr10_-_123008687 0.65 ENST00000617859.4
IKZF5
IKAROS family zinc finger 5
chr4_-_82561972 0.65 ENST00000454948.3
ENST00000449862.7
TMEM150C
transmembrane protein 150C
chr18_+_9136757 0.63 ENST00000262126.9
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr15_+_68054308 0.60 ENST00000249636.11
PIAS1
protein inhibitor of activated STAT 1
chr1_+_109213887 0.59 ENST00000234677.7
ENST00000369923.4
SARS1
seryl-tRNA synthetase 1
chr17_-_37609361 0.58 ENST00000614941.4
ENST00000619541.4
ENST00000622045.4
ENST00000616179.4
ENST00000621136.4
ENST00000612223.5
ENST00000620424.1
SYNRG
synergin gamma
chr4_+_168497066 0.56 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr1_+_52726441 0.55 ENST00000294353.7
ENST00000545132.5
ZYG11B
zyg-11 family member B, cell cycle regulator
chr19_+_10718047 0.53 ENST00000585892.5
ENST00000355667.11
ENST00000389253.9
ENST00000359692.10
DNM2
dynamin 2
chr14_+_99481395 0.53 ENST00000389879.9
ENST00000557441.5
ENST00000555049.5
ENST00000555842.1
CCNK
cyclin K
chr9_+_134880806 0.52 ENST00000291744.11
ENST00000350339.3
FCN2
ficolin 2
chr11_-_19240936 0.50 ENST00000250024.9
E2F8
E2F transcription factor 8
chr10_-_123008784 0.50 ENST00000368886.10
IKZF5
IKAROS family zinc finger 5
chr22_+_50508216 0.48 ENST00000420993.7
ENST00000395698.7
ENST00000395701.7
ENST00000523045.5
ENST00000299821.15
NCAPH2
non-SMC condensin II complex subunit H2
chr12_-_132687307 0.48 ENST00000535270.5
ENST00000320574.10
POLE
DNA polymerase epsilon, catalytic subunit
chr17_-_39197652 0.46 ENST00000394303.8
CACNB1
calcium voltage-gated channel auxiliary subunit beta 1
chr1_-_201112420 0.43 ENST00000362061.4
ENST00000681874.1
CACNA1S
calcium voltage-gated channel subunit alpha1 S
chr17_-_4142963 0.43 ENST00000381638.7
ZZEF1
zinc finger ZZ-type and EF-hand domain containing 1
chr1_-_201112451 0.42 ENST00000367338.7
CACNA1S
calcium voltage-gated channel subunit alpha1 S
chr12_+_59596010 0.42 ENST00000547379.6
ENST00000552432.5
SLC16A7
solute carrier family 16 member 7
chr4_+_3074661 0.41 ENST00000355072.11
HTT
huntingtin
chr14_+_24070837 0.41 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
CPNE6
copine 6
chr2_+_172860038 0.40 ENST00000538974.5
ENST00000540783.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr2_+_232456146 0.40 ENST00000295463.4
ALPI
alkaline phosphatase, intestinal
chr1_+_39081410 0.39 ENST00000602421.5
ENST00000361689.7
MACF1
microtubule actin crosslinking factor 1
chr18_+_9913979 0.38 ENST00000400000.7
ENST00000340541.4
VAPA
VAMP associated protein A
chr2_-_218659592 0.37 ENST00000411696.7
ZNF142
zinc finger protein 142
chr3_-_101677119 0.36 ENST00000312938.5
ZBTB11
zinc finger and BTB domain containing 11
chr2_+_112275588 0.35 ENST00000409871.6
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr15_+_33968484 0.34 ENST00000383263.7
CHRM5
cholinergic receptor muscarinic 5
chr4_-_46389351 0.30 ENST00000503806.5
ENST00000356504.5
ENST00000514090.5
ENST00000506961.5
GABRA2
gamma-aminobutyric acid type A receptor subunit alpha2
chr9_-_129835232 0.28 ENST00000372447.7
C9orf78
chromosome 9 open reading frame 78
chr2_-_218659468 0.27 ENST00000450560.1
ENST00000449707.5
ENST00000440934.2
ZNF142
zinc finger protein 142
chr7_-_42237187 0.25 ENST00000395925.8
GLI3
GLI family zinc finger 3
chr2_+_64453969 0.19 ENST00000464281.5
LGALSL
galectin like
chr14_+_61529005 0.18 ENST00000556347.1
ENSG00000258989.1
novel protein
chr13_-_27969295 0.18 ENST00000381020.8
CDX2
caudal type homeobox 2
chr17_-_3595831 0.16 ENST00000399759.7
TRPV1
transient receptor potential cation channel subfamily V member 1
chr1_-_156859087 0.14 ENST00000368195.4
INSRR
insulin receptor related receptor
chr11_-_101129706 0.10 ENST00000534013.5
PGR
progesterone receptor
chr19_-_48044037 0.09 ENST00000293255.3
CABP5
calcium binding protein 5
chr2_-_61538516 0.09 ENST00000676771.1
ENST00000677814.1
ENST00000443240.5
ENST00000677556.1
ENST00000676553.1
XPO1
exportin 1
chr11_-_101129806 0.08 ENST00000325455.10
ENST00000617858.4
ENST00000619228.2
PGR
progesterone receptor
chr6_+_110874775 0.08 ENST00000675380.1
ENST00000368882.8
ENST00000368877.9
ENST00000368885.8
ENST00000672937.2
AMD1
adenosylmethionine decarboxylase 1
chr19_-_6424772 0.07 ENST00000619396.4
ENST00000398148.7
KHSRP
KH-type splicing regulatory protein
chr9_+_130579556 0.05 ENST00000319725.10
FUBP3
far upstream element binding protein 3
chr11_-_19241598 0.05 ENST00000532666.1
ENST00000527884.5
ENST00000620009.4
E2F8
E2F transcription factor 8
chr19_+_7669043 0.01 ENST00000221515.6
RETN
resistin
chrX_+_16786421 0.01 ENST00000398155.4
ENST00000380122.10
TXLNG
taxilin gamma
chr19_+_7669080 0.01 ENST00000629642.1
RETN
resistin
chr19_-_48619127 0.01 ENST00000550973.5
ENST00000550645.5
ENST00000549273.5
ENST00000549920.6
ENST00000552588.5
RPL18
ribosomal protein L18
chr6_-_100881281 0.00 ENST00000369143.2
ENST00000369162.7
ENST00000324723.10
ENST00000522650.5
ASCC3
activating signal cointegrator 1 complex subunit 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
1.5 4.5 GO:1900154 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
1.4 4.3 GO:1990108 protein linear deubiquitination(GO:1990108)
1.1 2.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.6 1.8 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241) sarcomerogenesis(GO:0048769)
0.6 2.9 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.6 1.7 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.5 1.4 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.5 1.9 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.4 1.2 GO:0002125 maternal aggressive behavior(GO:0002125)
0.4 2.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.3 3.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 3.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.3 2.0 GO:0008218 bioluminescence(GO:0008218)
0.3 4.5 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.3 4.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 2.3 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 0.9 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.2 1.4 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 0.9 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.4 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1 2.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.5 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.8 GO:0023021 termination of signal transduction(GO:0023021)
0.1 0.6 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 1.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.1 2.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.2 GO:0060875 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
0.1 1.1 GO:0006600 creatine metabolic process(GO:0006600)
0.1 2.0 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 1.7 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.1 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.9 GO:0071313 cellular response to caffeine(GO:0071313)
0.1 1.3 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.5 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.8 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 1.4 GO:0030488 tRNA methylation(GO:0030488)
0.1 3.3 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.4 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.7 GO:0042572 retinol metabolic process(GO:0042572)
0.1 2.2 GO:0030199 collagen fibril organization(GO:0030199)
0.0 2.0 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 0.6 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.2 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 1.7 GO:0010107 potassium ion import(GO:0010107)
0.0 2.2 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.4 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 1.6 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.8 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 0.5 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.9 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 2.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 4.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.1 GO:0030238 male sex determination(GO:0030238)
0.0 1.0 GO:0021510 spinal cord development(GO:0021510)
0.0 2.8 GO:0021915 neural tube development(GO:0021915)
0.0 0.1 GO:0008215 spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295)
0.0 0.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0070695 FHF complex(GO:0070695)
0.5 3.8 GO:0061700 GATOR2 complex(GO:0061700)
0.4 2.1 GO:0043291 RAVE complex(GO:0043291)
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.2 13.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.5 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.1 1.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 4.0 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 3.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 5.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 6.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.3 GO:0031430 M band(GO:0031430)
0.0 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.8 GO:0042599 lamellar body(GO:0042599)
0.0 1.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 7.0 GO:0008021 synaptic vesicle(GO:0008021)
0.0 5.8 GO:0030426 growth cone(GO:0030426)
0.0 2.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.6 3.8 GO:0070728 leucine binding(GO:0070728)
0.5 4.5 GO:0016015 morphogen activity(GO:0016015)
0.5 2.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 2.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.4 6.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 1.5 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.2 GO:0031893 vasopressin receptor binding(GO:0031893)
0.2 1.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 3.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 1.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 1.7 GO:0031433 telethonin binding(GO:0031433)
0.2 1.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 1.1 GO:0004111 creatine kinase activity(GO:0004111)
0.1 5.2 GO:0050699 WW domain binding(GO:0050699)
0.1 1.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 2.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 2.2 GO:0071949 FAD binding(GO:0071949)
0.1 4.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 2.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.8 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.0 1.5 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.2 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 4.2 GO:0005179 hormone activity(GO:0005179)
0.0 2.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 2.5 GO:0004386 helicase activity(GO:0004386)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 5.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 1.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 3.4 PID BMP PATHWAY BMP receptor signaling
0.0 1.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.6 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 5.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 4.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 3.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 3.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.4 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.1 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 6.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 3.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 3.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 1.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 2.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 1.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.2 REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling