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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PLAG1

Z-value: 3.56

Motif logo

Transcription factors associated with PLAG1

Gene Symbol Gene ID Gene Info
ENSG00000181690.8 PLAG1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PLAG1hg38_v1_chr8_-_56211257_562113090.251.8e-04Click!

Activity profile of PLAG1 motif

Sorted Z-values of PLAG1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PLAG1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_+_136980211 20.52 ENST00000444903.2
prostaglandin D2 synthase
chr6_-_83709019 19.47 ENST00000519779.5
ENST00000369694.6
ENST00000195649.10
synaptosome associated protein 91
chr12_+_78864768 17.07 ENST00000261205.9
ENST00000457153.6
synaptotagmin 1
chr8_+_22054817 13.66 ENST00000432128.5
ENST00000443491.6
ENST00000517600.5
ENST00000523782.6
dematin actin binding protein
chrX_+_111096211 11.41 ENST00000372010.5
ENST00000519681.5
p21 (RAC1) activated kinase 3
chr2_+_241188509 11.19 ENST00000674324.1
ENST00000274979.12
anoctamin 7
chr11_-_57514876 10.87 ENST00000528450.5
solute carrier family 43 member 1
chr5_+_161848112 10.61 ENST00000393943.10
gamma-aminobutyric acid type A receptor subunit alpha1
chr11_-_73598067 10.41 ENST00000450446.6
ENST00000356467.5
family with sequence similarity 168 member A
chrX_+_111096136 10.34 ENST00000372007.10
p21 (RAC1) activated kinase 3
chrX_-_138711663 9.89 ENST00000315930.11
fibroblast growth factor 13
chr11_-_73598183 9.59 ENST00000064778.8
family with sequence similarity 168 member A
chr1_+_163068775 8.95 ENST00000421743.6
regulator of G protein signaling 4
chr5_+_161848536 8.79 ENST00000519621.2
ENST00000636573.1
gamma-aminobutyric acid type A receptor subunit alpha1
chrX_+_52184874 8.59 ENST00000599522.7
ENST00000471932.6
MAGE family member D4
chr5_+_161848314 8.40 ENST00000437025.6
gamma-aminobutyric acid type A receptor subunit alpha1
chr22_+_29073112 8.16 ENST00000327813.9
ENST00000407188.5
kringle containing transmembrane protein 1
chr12_-_112382363 7.96 ENST00000682272.1
ENST00000377560.9
HECT domain E3 ubiquitin protein ligase 4
chr7_-_158587710 7.82 ENST00000389416.8
protein tyrosine phosphatase receptor type N2
chr1_+_150257247 7.55 ENST00000647854.1
carbonic anhydrase 14
chr19_+_4639505 7.22 ENST00000327473.9
TNF alpha induced protein 8 like 1
chr5_-_55534955 7.19 ENST00000307259.9
ENST00000264775.9
phospholipid phosphatase 1
chr16_-_29899532 7.00 ENST00000308713.9
ENST00000617533.5
seizure related 6 homolog like 2
chr12_-_12266769 6.83 ENST00000543091.1
LDL receptor related protein 6
chr14_+_79279339 6.72 ENST00000557594.5
neurexin 3
chr14_-_53153281 6.51 ENST00000357758.3
ENST00000673822.2
DDHD domain containing 1
chr12_-_27780236 6.37 ENST00000381273.4
MANSC domain containing 4
chr14_+_79279906 6.29 ENST00000428277.6
neurexin 3
chr12_-_52321395 6.15 ENST00000293670.3
keratin 83
chr14_-_81220951 6.13 ENST00000553612.6
general transcription factor IIA subunit 1
chr2_-_152098810 5.94 ENST00000636442.1
ENST00000638005.1
calcium voltage-gated channel auxiliary subunit beta 4
chrX_-_45200828 5.91 ENST00000398000.7
divergent protein kinase domain 2B
chr14_-_53153098 5.78 ENST00000612692.4
ENST00000395606.5
DDHD domain containing 1
chr9_-_132944600 5.76 ENST00000490179.3
ENST00000643583.1
ENST00000298552.9
ENST00000643072.1
ENST00000642745.1
ENST00000647462.1
ENST00000643875.1
ENST00000642627.1
ENST00000475903.6
ENST00000642617.1
ENST00000642646.1
ENST00000646625.1
ENST00000645150.1
ENST00000645129.1
ENST00000403810.6
ENST00000643691.1
ENST00000644097.1
TSC complex subunit 1
chr2_-_152098670 5.70 ENST00000636129.1
ENST00000636785.1
ENST00000636496.1
calcium voltage-gated channel auxiliary subunit beta 4
chr7_+_73328177 5.58 ENST00000442793.5
ENST00000413573.6
FKBP prolyl isomerase family member 6 (inactive)
chr3_-_51967410 5.45 ENST00000461554.6
ENST00000483411.5
ENST00000461544.2
ENST00000355852.6
poly(rC) binding protein 4
chr17_-_4704040 5.42 ENST00000570571.5
ENST00000575101.1
ENST00000574876.5
ENST00000572293.7
proline, glutamate and leucine rich protein 1
chr16_-_29899043 5.37 ENST00000346932.9
ENST00000350527.7
ENST00000568380.1
seizure related 6 homolog like 2
chr6_-_29628038 5.37 ENST00000355973.7
ENST00000377012.8
gamma-aminobutyric acid type B receptor subunit 1
chr10_-_73811583 5.36 ENST00000309979.11
N-deacetylase and N-sulfotransferase 2
chr3_-_51968387 5.31 ENST00000490063.5
ENST00000468324.5
ENST00000497653.5
ENST00000484633.5
poly(rC) binding protein 4
chr14_+_79279403 5.23 ENST00000281127.11
neurexin 3
chr16_-_29899245 5.16 ENST00000537485.5
seizure related 6 homolog like 2
chr19_-_38229654 5.13 ENST00000412732.5
ENST00000456296.5
double PHD fingers 1
chr19_-_13906062 5.01 ENST00000591586.5
ENST00000346736.6
break repair meiotic recombinase recruitment factor 1
chr19_+_40467145 5.00 ENST00000338932.7
spectrin beta, non-erythrocytic 4
chr7_+_73328152 4.99 ENST00000252037.5
ENST00000431982.6
FKBP prolyl isomerase family member 6 (inactive)
chr11_+_46277648 4.99 ENST00000621158.5
cAMP responsive element binding protein 3 like 1
chr17_-_76141240 4.91 ENST00000322957.7
forkhead box J1
chr14_-_21526312 4.80 ENST00000537235.2
spalt like transcription factor 2
chr6_-_32224060 4.66 ENST00000375023.3
notch receptor 4
chr2_-_152099023 4.64 ENST00000201943.10
ENST00000427385.6
ENST00000539935.7
calcium voltage-gated channel auxiliary subunit beta 4
chr14_+_79279681 4.63 ENST00000679122.1
neurexin 3
chr2_-_74391837 4.50 ENST00000417090.1
ENST00000409868.5
ENST00000680606.1
dynactin subunit 1
chr19_+_40466976 4.48 ENST00000598249.6
spectrin beta, non-erythrocytic 4
chr9_-_120714457 4.47 ENST00000373930.4
multiple EGF like domains 9
chrX_+_52184904 4.40 ENST00000375626.7
ENST00000467526.1
MAGE family member D4
chr1_-_31704001 4.39 ENST00000373672.8
collagen type XVI alpha 1 chain
chr14_+_79280056 4.35 ENST00000676811.1
neurexin 3
chr1_-_115338231 4.32 ENST00000369512.3
ENST00000680116.1
ENST00000681124.1
ENST00000675637.2
ENST00000676038.2
nerve growth factor
chr5_-_59893718 4.28 ENST00000340635.11
phosphodiesterase 4D
chr2_-_152099155 4.27 ENST00000637309.1
calcium voltage-gated channel auxiliary subunit beta 4
chr19_-_461007 4.22 ENST00000264554.11
SHC adaptor protein 2
chr17_+_75109939 4.19 ENST00000581078.1
ENST00000245543.6
ENST00000582136.5
armadillo repeat containing 7
chr2_-_74392025 4.15 ENST00000440727.1
ENST00000409240.5
dynactin subunit 1
chr10_-_97687191 4.11 ENST00000370626.4
arginine vasopressin induced 1
chr20_-_18057841 4.11 ENST00000278780.7
ovo like zinc finger 2
chr16_+_31117656 4.10 ENST00000219797.9
ENST00000448516.6
lysine acetyltransferase 8
chr12_-_57738740 4.06 ENST00000547588.6
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr21_-_36966612 3.75 ENST00000674895.3
holocarboxylase synthetase
chr17_+_49969178 3.68 ENST00000240306.5
distal-less homeobox 4
chr19_-_38229714 3.54 ENST00000416611.5
double PHD fingers 1
chr10_+_110007964 3.50 ENST00000277900.12
ENST00000356080.9
adducin 3
chr6_-_31972290 3.36 ENST00000375349.7
decapping exoribonuclease
chr12_-_48004496 3.31 ENST00000337299.7
collagen type II alpha 1 chain
chr14_-_74612226 3.25 ENST00000261978.9
latent transforming growth factor beta binding protein 2
chr2_-_73284431 3.24 ENST00000521871.5
ENST00000520530.3
F-box protein 41
chr22_+_29205877 3.21 ENST00000334018.11
ENST00000429226.5
ENST00000404755.7
ENST00000404820.7
ENST00000430127.1
EMI domain containing 1
chr4_+_54229261 3.14 ENST00000508170.5
ENST00000512143.1
ENST00000257290.10
platelet derived growth factor receptor alpha
chr1_-_204685700 3.14 ENST00000367177.4
leucine rich repeat neuronal 2
chr9_+_129081098 3.10 ENST00000406974.7
ENST00000372546.9
dolichyldiphosphatase 1
chr13_+_53028806 3.06 ENST00000219022.3
olfactomedin 4
chrX_-_72307148 3.06 ENST00000453707.6
ENST00000373619.7
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
chr4_+_61200318 3.04 ENST00000683033.1
adhesion G protein-coupled receptor L3
chr16_+_425599 2.96 ENST00000262305.9
RAB11 family interacting protein 3
chr12_-_12267003 2.91 ENST00000535731.1
ENST00000261349.9
LDL receptor related protein 6
chr4_+_41990496 2.88 ENST00000264451.12
solute carrier family 30 member 9
chr12_-_48004467 2.87 ENST00000380518.8
collagen type II alpha 1 chain
chr19_-_4535221 2.85 ENST00000381848.7
ENST00000586133.1
perilipin 5
chr2_-_29921580 2.78 ENST00000389048.8
ALK receptor tyrosine kinase
chr1_-_110070654 2.71 ENST00000647563.2
ALX homeobox 3
chr9_+_69325168 2.70 ENST00000303068.14
family with sequence similarity 189 member A2
chr7_-_27152561 2.70 ENST00000467897.2
ENST00000612286.5
ENST00000498652.1
novel transcript
homeobox A3
novel transcript
chr1_-_243850216 2.67 ENST00000673466.1
AKT serine/threonine kinase 3
chr9_-_133129395 2.65 ENST00000393157.8
ral guanine nucleotide dissociation stimulator
chr6_-_31972123 2.60 ENST00000337523.10
decapping exoribonuclease
chr7_-_100573865 2.55 ENST00000622764.3
Sin3A associated protein 25
chr14_-_25050111 2.46 ENST00000323944.9
syntaxin binding protein 6
chr2_-_178072751 2.45 ENST00000286063.11
phosphodiesterase 11A
chr12_-_108339300 2.29 ENST00000550402.6
ENST00000552995.5
ENST00000312143.11
chemerin chemokine-like receptor 1
chr2_+_240625237 2.20 ENST00000407714.1
G protein-coupled receptor 35
chr3_-_73624840 2.15 ENST00000308537.4
ENST00000263666.9
PDZ domain containing ring finger 3
chr14_-_25049889 2.05 ENST00000419632.6
ENST00000396700.5
syntaxin binding protein 6
chr3_-_15332526 2.04 ENST00000383791.8
SH3 domain binding protein 5
chr19_+_3359563 1.99 ENST00000589123.5
ENST00000395111.7
ENST00000586919.5
nuclear factor I C
chr6_-_36986122 1.90 ENST00000460219.2
ENST00000373627.10
ENST00000373616.9
mitochondrial carrier 1
chr19_+_38433676 1.89 ENST00000359596.8
ENST00000355481.8
ryanodine receptor 1
chr16_+_33827140 1.89 ENST00000562905.2
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr16_+_285680 1.89 ENST00000435833.1
protein disulfide isomerase family A member 2
chr1_+_4654732 1.88 ENST00000378190.7
adherens junctions associated protein 1
chr11_+_2301987 1.88 ENST00000612299.4
ENST00000182290.9
tetraspanin 32
chr3_+_135965718 1.77 ENST00000264977.8
ENST00000490467.5
protein phosphatase 2 regulatory subunit B''alpha
chr1_-_160070102 1.75 ENST00000638728.1
ENST00000637644.1
potassium inwardly rectifying channel subfamily J member 10
chr1_-_160070150 1.72 ENST00000644903.1
potassium inwardly rectifying channel subfamily J member 10
chr9_-_137032081 1.71 ENST00000314412.7
fucosyltransferase 7
chr14_-_31026363 1.66 ENST00000357479.10
ENST00000355683.9
striatin 3
chr1_+_2476284 1.60 ENST00000378486.8
phospholipase C eta 2
chr11_+_71527267 1.59 ENST00000398536.6
keratin associated protein 5-7
chr1_+_2476315 1.57 ENST00000419816.6
phospholipase C eta 2
chr10_-_70283998 1.52 ENST00000277942.7
neuropeptide FF receptor 1
chr16_+_14833713 1.42 ENST00000287667.12
ENST00000620755.4
ENST00000610363.4
NODAL modulator 1
chrX_+_150361559 1.39 ENST00000262858.8
mastermind like domain containing 1
chr6_+_106086316 1.36 ENST00000369091.6
ENST00000369096.9
PR/SET domain 1
chr2_+_156436423 1.36 ENST00000540309.5
glycerol-3-phosphate dehydrogenase 2
chr19_+_13906190 1.26 ENST00000318003.11
coiled-coil and C2 domain containing 1A
chr20_+_58891981 1.22 ENST00000488652.6
ENST00000476935.6
ENST00000492907.6
ENST00000603546.2
GNAS complex locus
chr3_-_116444983 1.17 ENST00000333617.8
limbic system associated membrane protein
chr19_+_13906255 1.17 ENST00000589606.5
coiled-coil and C2 domain containing 1A
chr20_+_1895365 1.15 ENST00000358771.5
signal regulatory protein alpha
chr20_+_36573458 1.08 ENST00000373874.6
TGFB induced factor homeobox 2
chr11_+_118607579 1.04 ENST00000530708.4
pleckstrin homology like domain family B member 1
chr6_-_35497042 1.03 ENST00000639578.3
ENST00000338863.13
TEA domain transcription factor 3
chr19_-_43754901 0.98 ENST00000270066.11
ENST00000601170.5
SMG9 nonsense mediated mRNA decay factor
chr1_-_24143112 0.92 ENST00000270800.2
interleukin 22 receptor subunit alpha 1
chr6_-_70303070 0.91 ENST00000370496.3
ENST00000357250.11
collagen type IX alpha 1 chain
chr1_-_19980416 0.88 ENST00000375111.7
phospholipase A2 group IIA
chr19_+_55385928 0.79 ENST00000431533.6
ENST00000428193.6
ENST00000558815.5
ENST00000344063.7
ENST00000560583.5
ENST00000560055.5
ENST00000559463.5
ribosomal protein L28
chr1_-_92483947 0.76 ENST00000370332.5
growth factor independent 1 transcriptional repressor
chr17_+_66835110 0.75 ENST00000533854.6
calcium voltage-gated channel auxiliary subunit gamma 5
chr16_+_56451513 0.71 ENST00000562150.5
ENST00000561646.5
ENST00000566157.6
ENST00000568397.1
2-oxoglutarate and iron dependent oxygenase domain containing 1
chr17_+_4951080 0.69 ENST00000521811.5
ENST00000323997.10
ENST00000522249.5
ENST00000519584.5
ENST00000519602.6
enolase 3
chr17_-_28812224 0.68 ENST00000582059.6
family with sequence similarity 222 member B
chr7_-_149773207 0.64 ENST00000484747.5
zinc finger protein 467
chr17_-_1400168 0.63 ENST00000573026.1
ENST00000575977.1
ENST00000571732.5
ENST00000264335.13
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
chr20_-_22584547 0.59 ENST00000419308.7
forkhead box A2
chr11_-_64744317 0.59 ENST00000419843.1
ENST00000394430.5
RAS guanyl releasing protein 2
chr5_-_177509814 0.58 ENST00000510898.7
ENST00000502885.5
ENST00000506493.5
docking protein 3
chr3_-_116445458 0.58 ENST00000490035.7
limbic system associated membrane protein
chr6_+_31971831 0.51 ENST00000375331.7
ENST00000375333.3
serine/threonine kinase 19
chr10_+_134465 0.50 ENST00000439456.5
ENST00000397962.8
ENST00000309776.8
ENST00000397959.7
zinc finger MYND-type containing 11
chr11_+_64285839 0.50 ENST00000438980.7
ENST00000540370.1
G protein-coupled receptor 137
chr14_-_21526391 0.49 ENST00000611430.4
spalt like transcription factor 2
chr2_-_109614143 0.48 ENST00000356688.8
septin 10
chr1_-_44017296 0.39 ENST00000357730.6
ENST00000360584.6
ENST00000528803.1
solute carrier family 6 member 9
chr5_+_175658008 0.39 ENST00000377291.2
histamine receptor H2
chr3_+_19947074 0.33 ENST00000273047.9
RAB5A, member RAS oncogene family
chr11_+_57338344 0.28 ENST00000263314.3
ENST00000616487.4
purinergic receptor P2X 3
chr1_+_202462730 0.20 ENST00000290419.9
ENST00000491336.5
protein phosphatase 1 regulatory subunit 12B
chr2_-_127642131 0.13 ENST00000426981.5
LIM zinc finger domain containing 2
chr4_-_98929092 0.12 ENST00000280892.10
ENST00000511644.5
ENST00000504432.5
ENST00000450253.7
ENST00000505992.1
eukaryotic translation initiation factor 4E
chr19_+_42284483 0.12 ENST00000575354.6
capicua transcriptional repressor
chr17_-_28812392 0.07 ENST00000452648.8
family with sequence similarity 222 member B
chr7_-_149773548 0.03 ENST00000302017.4
zinc finger protein 467

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.0 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
5.7 17.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
3.7 11.2 GO:0061590 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
3.2 9.7 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
2.3 9.3 GO:1990834 response to odorant(GO:1990834)
2.0 13.7 GO:0070560 protein secretion by platelet(GO:0070560)
1.5 10.6 GO:0034587 piRNA metabolic process(GO:0034587)
1.2 5.8 GO:0051029 rRNA transport(GO:0051029)
1.1 8.7 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
1.0 3.1 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.0 27.8 GO:0071420 cellular response to histamine(GO:0071420)
1.0 4.9 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.9 9.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.9 21.7 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.9 3.8 GO:0009305 protein biotinylation(GO:0009305) histone biotinylation(GO:0071110)
0.9 18.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.9 27.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.8 4.1 GO:0060214 endocardium formation(GO:0060214)
0.7 7.2 GO:0008354 germ cell migration(GO:0008354)
0.7 2.8 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.7 2.8 GO:0036269 swimming behavior(GO:0036269)
0.7 3.5 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.7 2.7 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.6 19.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.6 5.0 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.5 4.3 GO:0032455 nerve growth factor processing(GO:0032455)
0.5 4.7 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.5 3.1 GO:0071105 response to interleukin-11(GO:0071105)
0.5 4.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.5 1.9 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.5 1.4 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.5 4.5 GO:0051601 exocyst localization(GO:0051601)
0.4 3.1 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.4 5.4 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.4 12.0 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.4 3.0 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.4 6.2 GO:0060174 limb bud formation(GO:0060174)
0.3 1.7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.3 6.0 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.3 22.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.3 1.9 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.3 1.4 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.3 3.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.3 0.8 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.2 11.3 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 3.0 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.2 0.6 GO:0003064 regulation of heart rate by hormone(GO:0003064) negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.2 1.9 GO:0071313 cellular response to caffeine(GO:0071313)
0.2 1.0 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.2 4.1 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.2 0.6 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.2 5.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 4.4 GO:0033622 integrin activation(GO:0033622)
0.2 1.9 GO:0006621 protein retention in ER lumen(GO:0006621)
0.2 7.2 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.2 2.7 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 8.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 1.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 7.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 7.5 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2.3 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.1 2.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 10.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 1.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 1.7 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1 1.0 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.1 5.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 1.8 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 7.6 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 1.2 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 2.7 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.1 0.3 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 6.1 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 6.2 GO:0042633 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.1 3.3 GO:0097435 fibril organization(GO:0097435)
0.1 0.3 GO:0051036 regulation of endosome size(GO:0051036)
0.1 0.9 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 0.7 GO:0006449 regulation of translational termination(GO:0006449)
0.1 2.0 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 0.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 8.3 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 2.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 3.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 1.8 GO:0061053 somite development(GO:0061053)
0.0 2.0 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 4.1 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.0 8.0 GO:0033500 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 0.7 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.4 GO:0001696 gastric acid secretion(GO:0001696)
0.0 1.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.5 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 17.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
2.4 9.7 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
1.4 5.8 GO:0033596 TSC1-TSC2 complex(GO:0033596)
1.3 5.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.9 9.5 GO:0070852 cell body fiber(GO:0070852)
0.7 27.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.7 6.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.7 5.3 GO:0005593 FACIT collagen trimer(GO:0005593)
0.6 8.7 GO:0005869 dynactin complex(GO:0005869)
0.5 13.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731) platelet dense tubular network membrane(GO:0031095)
0.5 4.1 GO:0072487 MSL complex(GO:0072487)
0.5 6.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 24.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 1.9 GO:0030314 junctional membrane complex(GO:0030314) ryanodine receptor complex(GO:1990425)
0.3 1.9 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 4.5 GO:0000145 exocyst(GO:0000145)
0.2 8.7 GO:0071565 nBAF complex(GO:0071565)
0.2 10.6 GO:0000795 synaptonemal complex(GO:0000795)
0.2 1.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 4.2 GO:0016342 catenin complex(GO:0016342)
0.2 5.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 3.8 GO:0005652 nuclear lamina(GO:0005652)
0.2 19.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 19.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.0 GO:0045180 basal cortex(GO:0045180)
0.1 8.2 GO:0043195 terminal bouton(GO:0043195)
0.1 31.1 GO:0098793 presynapse(GO:0098793)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 3.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 2.7 GO:0045095 keratin filament(GO:0045095)
0.1 8.4 GO:0030175 filopodium(GO:0030175)
0.1 3.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.1 GO:0005902 microvillus(GO:0005902)
0.0 3.0 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.9 GO:0008305 integrin complex(GO:0008305)
0.0 3.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 3.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.4 GO:0043204 perikaryon(GO:0043204)
0.0 1.7 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.9 GO:0001650 fibrillar center(GO:0001650)
0.0 71.1 GO:0031224 intrinsic component of membrane(GO:0031224)
0.0 0.1 GO:0033391 chromatoid body(GO:0033391)
0.0 0.6 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
3.4 17.1 GO:0030348 syntaxin-3 binding(GO:0030348)
3.2 9.7 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
3.1 27.8 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.5 6.0 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
1.3 5.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.3 5.4 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
1.2 7.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
1.1 4.3 GO:0005163 nerve growth factor receptor binding(GO:0005163)
1.0 3.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
1.0 27.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.9 3.8 GO:0018271 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.9 6.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.8 19.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.7 11.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.7 2.8 GO:0035473 lipase binding(GO:0035473)
0.6 20.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.6 21.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.5 4.1 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.5 1.9 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.5 2.8 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.4 7.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 23.1 GO:0030507 spectrin binding(GO:0030507)
0.4 10.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 3.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 1.4 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.3 8.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 11.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 5.0 GO:0035497 cAMP response element binding(GO:0035497)
0.2 7.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 0.9 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 5.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 4.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 4.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 0.6 GO:0050815 phosphoserine binding(GO:0050815)
0.2 2.4 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.2 3.1 GO:0050693 LBD domain binding(GO:0050693)
0.2 1.7 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 5.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.2 3.0 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 2.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 9.9 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 1.9 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.7 GO:0031544 peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.1 16.3 GO:0004620 phospholipase activity(GO:0004620)
0.1 0.9 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 3.9 GO:0070840 dynein complex binding(GO:0070840)
0.1 6.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 2.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 10.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 2.3 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 4.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.0 1.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 10.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 3.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.3 GO:0019838 growth factor binding(GO:0019838)
0.0 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 17.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.4 21.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 17.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.2 11.5 NABA COLLAGENS Genes encoding collagen proteins
0.2 7.0 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2 8.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 4.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 4.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 5.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 3.0 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 4.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.9 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 8.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.0 PID BCR 5PATHWAY BCR signaling pathway
0.0 2.6 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.2 PID P53 REGULATION PATHWAY p53 pathway
0.0 6.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 2.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 17.1 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.7 27.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 4.3 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.5 7.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.4 3.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.4 4.7 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.4 27.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 5.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 5.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 2.7 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 9.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 10.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 10.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 4.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 3.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 3.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 5.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 10.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 8.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 6.1 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 4.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.6 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 4.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 2.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 1.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis