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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for POU2F1

Z-value: 0.48

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Transcription factors associated with POU2F1

Gene Symbol Gene ID Gene Info
POU2F1
ENSG00000143190.23 POU2F1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU2F1hg38_v1_chr1_+_167220870_1672209270.161.7e-02Click!

Activity profile of POU2F1 motif

Sorted Z-values of POU2F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_90021567 20.58 ENST00000436451.2
IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr2_-_88992903 19.69 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr2_+_90069662 18.67 ENST00000390271.2
IGKV6D-41
immunoglobulin kappa variable 6D-41 (non-functional)
chr13_-_46142834 16.10 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr11_-_58575846 15.42 ENST00000395074.7
LPXN
leupaxin
chr14_-_106185387 15.07 ENST00000390605.2
IGHV1-18
immunoglobulin heavy variable 1-18
chr3_-_155806260 15.04 ENST00000534941.2
ENST00000340171.7
C3orf33
chromosome 3 open reading frame 33
chr1_+_158831323 14.36 ENST00000368141.5
MNDA
myeloid cell nuclear differentiation antigen
chr14_-_106025628 13.97 ENST00000631943.1
IGHV7-4-1
immunoglobulin heavy variable 7-4-1
chr3_-_121660892 12.92 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr21_-_10649835 12.72 ENST00000622028.1
IGHV1OR21-1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr2_-_89245596 11.60 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr3_-_108058361 11.29 ENST00000398258.7
CD47
CD47 molecule
chr14_-_105987068 11.05 ENST00000390594.3
IGHV1-2
immunoglobulin heavy variable 1-2
chr14_-_106622837 11.04 ENST00000390628.3
IGHV1-58
immunoglobulin heavy variable 1-58
chr2_-_89330429 10.55 ENST00000620613.1
IGKV2-40
immunoglobulin kappa variable 2-40
chr1_-_160711803 10.53 ENST00000368045.3
ENST00000368046.8
ENST00000613788.1
CD48
CD48 molecule
chr14_-_106715166 10.47 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr15_-_21718245 10.46 ENST00000630556.1
ENSG00000281179.1
novel gene identicle to IGHV1OR15-1
chr14_-_106277039 9.79 ENST00000390610.2
IGHV1-24
immunoglobulin heavy variable 1-24
chr14_-_106012390 9.32 ENST00000455737.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr2_+_89936859 8.31 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr4_+_40192949 7.77 ENST00000507851.5
ENST00000615577.4
ENST00000613272.4
RHOH
ras homolog family member H
chr14_-_106875069 7.49 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr1_-_24964984 7.31 ENST00000338888.3
ENST00000399916.5
RUNX3
RUNX family transcription factor 3
chr2_-_89222461 6.78 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chrX_-_136880715 6.75 ENST00000431446.7
ENST00000320676.11
ENST00000562646.5
RBMX
RNA binding motif protein X-linked
chr2_+_86907953 6.54 ENST00000409776.6
RGPD1
RANBP2 like and GRIP domain containing 1
chr8_-_116755784 5.89 ENST00000518949.5
ENST00000522453.1
ENST00000518995.5
ENST00000521861.6
ENST00000611080.1
EIF3H
eukaryotic translation initiation factor 3 subunit H
chr6_+_135181323 5.65 ENST00000367814.8
MYB
MYB proto-oncogene, transcription factor
chr9_+_131190119 5.55 ENST00000483497.6
NUP214
nucleoporin 214
chr4_+_67558719 5.53 ENST00000265404.7
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr14_-_106005574 5.21 ENST00000390595.3
IGHV1-3
immunoglobulin heavy variable 1-3
chr6_+_135181268 5.19 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB
MYB proto-oncogene, transcription factor
chr15_+_48331011 5.07 ENST00000559935.5
ENST00000559416.5
DUT
deoxyuridine triphosphatase
chr22_+_22686724 4.89 ENST00000390305.2
IGLV3-25
immunoglobulin lambda variable 3-25
chr21_-_29061351 4.69 ENST00000432178.5
CCT8
chaperonin containing TCP1 subunit 8
chr8_-_7018295 4.48 ENST00000327857.7
DEFA3
defensin alpha 3
chr15_-_55249029 4.12 ENST00000566877.5
RAB27A
RAB27A, member RAS oncogene family
chr3_-_64019334 3.88 ENST00000480205.5
PSMD6
proteasome 26S subunit, non-ATPase 6
chr10_+_78033760 3.83 ENST00000435275.5
ENST00000613865.5
ENST00000645440.1
ENST00000464716.6
ENST00000360830.9
ENST00000372360.9
ENST00000440692.6
RPS24
ribosomal protein S24
chr7_+_80638510 3.81 ENST00000433696.6
ENST00000538969.5
ENST00000544133.5
CD36
CD36 molecule
chr8_-_6999198 3.78 ENST00000382689.8
DEFA1B
defensin alpha 1B
chr8_-_6980092 3.77 ENST00000382692.3
DEFA1
defensin alpha 1
chr20_+_41028814 3.77 ENST00000361337.3
TOP1
DNA topoisomerase I
chr12_-_118359639 3.71 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr19_-_9621195 3.66 ENST00000424629.5
ENST00000326044.9
ENST00000435550.5
ENST00000302851.8
ENST00000444611.5
ENST00000421525.5
ZNF561
zinc finger protein 561
chr2_+_102473219 3.64 ENST00000295269.5
SLC9A4
solute carrier family 9 member A4
chr4_-_144019287 3.42 ENST00000638448.1
ENST00000513128.5
ENST00000506516.6
ENST00000429670.3
ENST00000502664.6
GYPB
glycophorin B (MNS blood group)
chr3_-_58214671 3.24 ENST00000460422.1
ENST00000483681.5
DNASE1L3
deoxyribonuclease 1 like 3
chr22_+_22747383 3.02 ENST00000390311.3
IGLV3-16
immunoglobulin lambda variable 3-16
chr7_+_65373839 3.01 ENST00000431504.1
ENST00000328747.12
ZNF92
zinc finger protein 92
chr7_+_65373873 3.00 ENST00000450302.2
ZNF92
zinc finger protein 92
chr7_+_65373799 2.98 ENST00000357512.3
ZNF92
zinc finger protein 92
chr11_-_128587551 2.96 ENST00000392668.8
ETS1
ETS proto-oncogene 1, transcription factor
chr9_-_83978429 2.85 ENST00000351839.7
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr7_+_57450171 2.81 ENST00000420713.2
ZNF716
zinc finger protein 716
chr2_+_161231078 2.78 ENST00000439442.1
TANK
TRAF family member associated NFKB activator
chr4_-_143905529 2.74 ENST00000358615.9
ENST00000437468.2
GYPE
glycophorin E (MNS blood group)
chr1_+_25272439 2.70 ENST00000648012.1
RHD
Rh blood group D antigen
chr1_+_28236096 2.48 ENST00000497986.5
ENST00000335514.10
ENST00000468425.2
ENST00000465645.1
ATP5IF1
ATP synthase inhibitory factor subunit 1
chr20_+_37744630 2.46 ENST00000373473.5
CTNNBL1
catenin beta like 1
chr21_-_32603237 2.43 ENST00000431599.1
CFAP298
cilia and flagella associated protein 298
chr1_+_103750406 2.43 ENST00000370079.3
AMY1C
amylase alpha 1C
chr19_+_17747698 2.41 ENST00000594202.5
ENST00000252771.11
FCHO1
FCH and mu domain containing endocytic adaptor 1
chr10_+_13586933 2.40 ENST00000417658.5
ENST00000378572.8
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr19_+_17747737 2.39 ENST00000600676.5
ENST00000600209.5
ENST00000596309.5
ENST00000598539.5
ENST00000597474.5
ENST00000593385.5
ENST00000598067.5
ENST00000593833.5
FCHO1
FCH and mu domain containing endocytic adaptor 1
chr6_+_135181361 2.31 ENST00000527615.5
ENST00000420123.6
ENST00000525369.5
ENST00000528774.5
ENST00000533624.5
ENST00000534044.5
ENST00000534121.5
MYB
MYB proto-oncogene, transcription factor
chr5_+_68292562 2.31 ENST00000523872.1
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr1_+_25272479 1.82 ENST00000622561.4
RHD
Rh blood group D antigen
chr8_+_85209213 1.81 ENST00000520225.1
E2F5
E2F transcription factor 5
chr3_-_3179674 1.78 ENST00000424814.5
ENST00000450014.1
ENST00000231948.9
ENST00000432408.6
ENST00000639284.1
CRBN
cereblon
chr4_-_99435336 1.77 ENST00000437033.7
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr4_-_99435134 1.75 ENST00000476959.5
ENST00000482593.5
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr3_+_101827982 1.70 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKBIZ
NFKB inhibitor zeta
chr2_+_227616998 1.64 ENST00000641801.1
SCYGR4
small cysteine and glycine repeat containing 4
chr4_-_152352800 1.64 ENST00000393956.9
FBXW7
F-box and WD repeat domain containing 7
chr14_-_64879900 1.64 ENST00000644917.1
ENST00000389720.4
SPTB
spectrin beta, erythrocytic
chr9_+_132978651 1.61 ENST00000636137.1
GFI1B
growth factor independent 1B transcriptional repressor
chr1_+_161766309 1.59 ENST00000679853.1
ENST00000681492.1
ENST00000679886.1
ENST00000367942.4
ENST00000680462.1
ENST00000680633.1
ENST00000681912.1
ATF6
activating transcription factor 6
chr6_-_132513045 1.48 ENST00000367941.7
ENST00000367937.4
STX7
syntaxin 7
chr1_+_25272527 1.48 ENST00000342055.9
ENST00000357542.8
ENST00000417538.6
ENST00000423810.6
ENST00000568195.5
RHD
Rh blood group D antigen
chr16_-_46748337 1.41 ENST00000394809.9
MYLK3
myosin light chain kinase 3
chr6_-_26216673 1.34 ENST00000541790.3
H2BC8
H2B clustered histone 8
chr17_+_77185210 1.28 ENST00000431431.6
SEC14L1
SEC14 like lipid binding 1
chr13_-_40771105 1.26 ENST00000323563.8
MRPS31
mitochondrial ribosomal protein S31
chr8_-_92095598 1.23 ENST00000520724.5
ENST00000518844.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr12_+_59664677 1.22 ENST00000548610.5
SLC16A7
solute carrier family 16 member 7
chr3_+_196739839 1.20 ENST00000327134.7
PAK2
p21 (RAC1) activated kinase 2
chr4_-_99435396 1.19 ENST00000209665.8
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr1_-_226739271 1.17 ENST00000429204.6
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr2_-_73779968 1.11 ENST00000452812.1
ENST00000443070.5
ENST00000272444.7
DUSP11
dual specificity phosphatase 11
chr14_+_55271344 1.11 ENST00000681400.1
ENST00000679934.1
ENST00000681904.1
ENST00000313833.5
FBXO34
F-box protein 34
chr13_-_113208087 1.09 ENST00000375459.5
PCID2
PCI domain containing 2
chr14_-_21456050 1.08 ENST00000645929.1
ENST00000646647.2
CHD8
chromodomain helicase DNA binding protein 8
chr6_+_12957301 1.07 ENST00000676234.1
PHACTR1
phosphatase and actin regulator 1
chr8_-_85378105 0.96 ENST00000521846.5
ENST00000523022.6
ENST00000524324.5
ENST00000519991.5
ENST00000520663.5
ENST00000517590.5
ENST00000522579.5
ENST00000522814.5
ENST00000522662.5
ENST00000523858.5
ENST00000519129.5
CA1
carbonic anhydrase 1
chr17_-_43833137 0.89 ENST00000398389.9
MPP3
membrane palmitoylated protein 3
chr16_-_67833842 0.88 ENST00000566758.5
ENST00000626059.2
ENST00000564817.5
CENPT
centromere protein T
chr11_-_5227063 0.83 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr17_+_47651061 0.77 ENST00000540627.5
KPNB1
karyopherin subunit beta 1
chr6_-_123636979 0.70 ENST00000662930.1
TRDN
triadin
chr17_+_36064265 0.64 ENST00000616054.2
CCL18
C-C motif chemokine ligand 18
chr1_+_103749898 0.64 ENST00000622339.5
AMY1C
amylase alpha 1C
chr3_-_165078480 0.64 ENST00000264382.8
SI
sucrase-isomaltase
chr4_+_73436198 0.62 ENST00000395792.7
AFP
alpha fetoprotein
chr2_+_70978624 0.59 ENST00000360589.4
ANKRD53
ankyrin repeat domain 53
chr4_+_73436244 0.58 ENST00000226359.2
AFP
alpha fetoprotein
chr5_+_151447576 0.57 ENST00000243389.8
ENST00000616007.4
ENST00000517945.5
ENST00000521925.5
SLC36A1
solute carrier family 36 member 1
chr12_-_110920568 0.55 ENST00000548438.1
ENST00000228841.15
MYL2
myosin light chain 2
chr2_+_108621260 0.53 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr18_+_616711 0.51 ENST00000579494.1
CLUL1
clusterin like 1
chr4_+_69995958 0.48 ENST00000381060.2
ENST00000246895.9
STATH
statherin
chr3_-_46208304 0.47 ENST00000296140.4
CCR1
C-C motif chemokine receptor 1
chr7_+_7566866 0.46 ENST00000405785.5
ENST00000340080.9
ENST00000433635.1
MIOS
meiosis regulator for oocyte development
chr3_-_111595339 0.46 ENST00000317012.5
ZBED2
zinc finger BED-type containing 2
chr9_+_113505256 0.45 ENST00000374136.5
RGS3
regulator of G protein signaling 3
chr16_-_370514 0.45 ENST00000199706.13
MRPL28
mitochondrial ribosomal protein L28
chr7_+_28412511 0.44 ENST00000357727.7
CREB5
cAMP responsive element binding protein 5
chr7_-_13986439 0.41 ENST00000443608.5
ENST00000438956.5
ETV1
ETS variant transcription factor 1
chr10_-_114144599 0.41 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr12_+_112906949 0.38 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
OAS1
2'-5'-oligoadenylate synthetase 1
chr18_+_3252208 0.38 ENST00000578562.6
MYL12A
myosin light chain 12A
chr6_-_25830557 0.36 ENST00000468082.1
SLC17A1
solute carrier family 17 member 1
chr16_+_81037187 0.35 ENST00000564241.5
ENST00000565237.1
ATMIN
ATM interactor
chr8_-_92095627 0.33 ENST00000517919.5
ENST00000617740.4
ENST00000613302.4
ENST00000436581.6
ENST00000614812.4
ENST00000519847.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr12_+_112907006 0.30 ENST00000680455.1
ENST00000551241.6
ENST00000550689.2
ENST00000679841.1
ENST00000679494.1
ENST00000553185.2
OAS1
2'-5'-oligoadenylate synthetase 1
chr2_-_112836702 0.24 ENST00000416750.1
ENST00000263341.7
ENST00000418817.5
IL1B
interleukin 1 beta
chr8_-_48921419 0.23 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chr12_+_112906777 0.15 ENST00000452357.7
ENST00000445409.7
OAS1
2'-5'-oligoadenylate synthetase 1
chr4_+_70430487 0.13 ENST00000413702.5
MUC7
mucin 7, secreted
chr2_+_203706475 0.13 ENST00000374481.7
ENST00000458610.6
CD28
CD28 molecule
chr2_+_70978380 0.11 ENST00000272421.10
ENST00000441349.5
ENST00000457410.5
ANKRD53
ankyrin repeat domain 53
chr2_-_112433519 0.11 ENST00000496537.1
ENST00000330575.9
ENST00000302558.8
RGPD8
RANBP2 like and GRIP domain containing 8
chr17_+_7484357 0.11 ENST00000674977.2
POLR2A
RNA polymerase II subunit A
chr19_+_14583076 0.10 ENST00000547437.5
ENST00000417570.6
CLEC17A
C-type lectin domain containing 17A
chr11_-_101129706 0.09 ENST00000534013.5
PGR
progesterone receptor
chr6_+_26124161 0.07 ENST00000377791.4
ENST00000602637.1
H2AC6
H2A clustered histone 6
chr7_+_55365317 0.04 ENST00000254770.3
LANCL2
LanC like 2
chr2_+_203706614 0.04 ENST00000324106.9
CD28
CD28 molecule
chr7_-_104207957 0.03 ENST00000447452.6
ENST00000297431.9
ENST00000626700.1
ORC5
origin recognition complex subunit 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.2 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
1.9 15.4 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
1.8 5.5 GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
1.7 5.1 GO:0046081 dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081)
1.3 3.8 GO:0035915 pore formation in membrane of other organism(GO:0035915)
1.2 4.7 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.9 12.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.8 61.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.8 16.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.8 2.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.7 2.9 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.7 0.7 GO:1903781 positive regulation of cardiac conduction(GO:1903781)
0.7 4.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.6 14.4 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.5 47.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.5 10.7 GO:0008228 opsonization(GO:0008228)
0.5 1.4 GO:0048769 sarcomerogenesis(GO:0048769)
0.5 2.8 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.4 1.6 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.4 7.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 1.1 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.4 1.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.3 4.7 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.3 4.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.3 1.5 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.3 3.0 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.3 6.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 3.8 GO:0040016 DNA topological change(GO:0006265) embryonic cleavage(GO:0040016)
0.3 0.8 GO:0030185 nitric oxide transport(GO:0030185)
0.3 44.9 GO:0002377 immunoglobulin production(GO:0002377)
0.3 3.6 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 0.2 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.2 1.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 1.2 GO:0001781 neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029)
0.2 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 1.8 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.2 5.4 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 6.0 GO:0015695 organic cation transport(GO:0015695)
0.2 3.2 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.2 2.3 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.2 4.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 1.1 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.2 0.8 GO:0031291 Ran protein signal transduction(GO:0031291)
0.2 1.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.5 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.1 10.9 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 3.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 5.5 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 43.2 GO:0002250 adaptive immune response(GO:0002250)
0.1 0.7 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 1.3 GO:0015871 choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 0.6 GO:0015808 L-alanine transport(GO:0015808)
0.1 3.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 6.6 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) mast cell activation(GO:0045576)
0.1 0.9 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.5 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.2 GO:0042448 progesterone metabolic process(GO:0042448)
0.1 5.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.5 GO:0046541 saliva secretion(GO:0046541)
0.0 1.6 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 3.9 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.0 0.5 GO:0002407 dendritic cell chemotaxis(GO:0002407)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.4 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 1.6 GO:0051693 actin filament capping(GO:0051693)
0.0 0.9 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.5 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.0 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 1.0 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 1.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.5 GO:1903393 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of adherens junction organization(GO:1903393)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 0.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
1.1 57.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.0 6.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.6 34.4 GO:0002102 podosome(GO:0002102)
0.6 5.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.6 2.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.4 3.8 GO:0031298 replication fork protection complex(GO:0031298)
0.4 4.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.3 4.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 1.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 0.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 22.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 0.7 GO:0030314 junctional membrane complex(GO:0030314)
0.1 3.9 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.6 GO:0000974 Prp19 complex(GO:0000974)
0.1 8.2 GO:0001772 immunological synapse(GO:0001772)
0.1 15.1 GO:0035579 specific granule membrane(GO:0035579)
0.1 1.6 GO:0008091 spectrin(GO:0008091)
0.1 16.3 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.4 GO:0005682 U5 snRNP(GO:0005682)
0.1 10.3 GO:0072562 blood microparticle(GO:0072562)
0.1 0.5 GO:0061700 GATOR2 complex(GO:0061700)
0.1 3.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.5 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.1 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 11.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 10.5 GO:0045121 membrane raft(GO:0045121)
0.0 1.1 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0004170 dUTP diphosphatase activity(GO:0004170)
1.3 15.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.3 3.8 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
1.2 13.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.2 4.7 GO:0004031 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
1.1 5.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.0 57.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.7 120.9 GO:0003823 antigen binding(GO:0003823)
0.5 2.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.4 1.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.4 1.1 GO:0098519 polynucleotide 5'-phosphatase activity(GO:0004651) nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.4 5.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.4 3.6 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.4 1.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 4.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.3 6.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.3 2.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.3 GO:0039552 RIG-I binding(GO:0039552)
0.2 1.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 0.6 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.2 6.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 1.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.2 0.5 GO:0046848 hydroxyapatite binding(GO:0046848)
0.2 4.1 GO:0031489 myosin V binding(GO:0031489)
0.1 0.6 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.1 3.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 1.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.8 GO:0030492 hemoglobin binding(GO:0030492)
0.1 1.0 GO:0004064 arylesterase activity(GO:0004064)
0.1 3.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 5.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.5 GO:0035497 cAMP response element binding(GO:0035497)
0.1 14.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 2.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 1.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.6 GO:0030506 ankyrin binding(GO:0030506)
0.1 3.2 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 11.3 GO:0051015 actin filament binding(GO:0051015)
0.0 0.4 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 1.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 6.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.3 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.2 15.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 14.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 6.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 5.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 3.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 9.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.6 PID MYC PATHWAY C-MYC pathway
0.0 3.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.0 REACTOME DEFENSINS Genes involved in Defensins
0.4 11.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 3.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 3.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 6.3 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2 6.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 4.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 1.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 9.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 9.3 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 7.7 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 1.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.0 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 9.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 6.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 4.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 4.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 4.7 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway