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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for POU4F2

Z-value: 0.59

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU4F2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg38_v1_chr4_+_146638890_146638894-0.161.8e-02Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_18683932 6.03 ENST00000615573.4
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_18684033 5.51 ENST00000614430.3
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_18684093 5.38 ENST00000428502.6
PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_58627567 4.32 ENST00000649301.1
FAM107A
family with sequence similarity 107 member A
chr10_-_114684457 3.71 ENST00000392955.7
ABLIM1
actin binding LIM protein 1
chr10_-_114684612 3.38 ENST00000533213.6
ENST00000369252.8
ABLIM1
actin binding LIM protein 1
chr10_-_72088533 2.96 ENST00000373109.7
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr9_+_122370523 2.93 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr12_-_89352487 2.92 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr12_-_89352395 2.78 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr2_-_49973939 2.77 ENST00000630656.1
NRXN1
neurexin 1
chr17_-_10026265 2.71 ENST00000437099.6
ENST00000396115.6
GAS7
growth arrest specific 7
chr5_-_135578983 2.15 ENST00000512158.6
CXCL14
C-X-C motif chemokine ligand 14
chr1_+_50108856 2.07 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAVL4
ELAV like RNA binding protein 4
chr1_+_40040720 1.76 ENST00000414893.5
ENST00000372792.7
ENST00000372805.8
ENST00000414281.5
ENST00000420216.5
ENST00000372798.5
ENST00000340450.7
ENST00000435719.5
ENST00000427843.5
ENST00000417287.5
ENST00000424977.1
CAP1
cyclase associated actin cytoskeleton regulatory protein 1
chr12_-_118359639 1.76 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr1_+_198638968 1.54 ENST00000348564.11
ENST00000530727.5
ENST00000442510.8
ENST00000645247.1
ENST00000367367.8
ENST00000367364.5
ENST00000413409.6
PTPRC
protein tyrosine phosphatase receptor type C
chr9_-_76906041 1.33 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
PRUNE2
prune homolog 2 with BCH domain
chr9_-_76906090 1.16 ENST00000376718.8
PRUNE2
prune homolog 2 with BCH domain
chr20_+_57561103 1.12 ENST00000319441.6
PCK1
phosphoenolpyruvate carboxykinase 1
chr14_-_89619118 0.96 ENST00000345097.8
ENST00000555855.5
ENST00000555353.5
FOXN3
forkhead box N3
chr6_+_39792298 0.91 ENST00000633794.1
ENST00000274867.9
DAAM2
dishevelled associated activator of morphogenesis 2
chr9_+_122371036 0.85 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr10_-_20897288 0.85 ENST00000377122.9
NEBL
nebulette
chrX_+_103585478 0.84 ENST00000468024.5
ENST00000415568.2
ENST00000472484.6
ENST00000613326.4
ENST00000490644.5
ENST00000459722.1
ENST00000472745.1
ENST00000494801.5
ENST00000434216.2
TCEAL4
transcription elongation factor A like 4
chr11_+_118304721 0.82 ENST00000361763.9
CD3E
CD3e molecule
chr15_-_37101205 0.81 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
MEIS2
Meis homeobox 2
chr3_-_9249623 0.79 ENST00000383836.8
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr10_+_97584347 0.72 ENST00000370649.3
ENST00000370646.9
ENSG00000249967.1
HOGA1
novel protein
4-hydroxy-2-oxoglutarate aldolase 1
chr6_-_25874212 0.71 ENST00000361703.10
ENST00000397060.8
SLC17A3
solute carrier family 17 member 3
chr12_-_52385649 0.68 ENST00000257951.3
KRT84
keratin 84
chr9_-_14307928 0.68 ENST00000637640.1
ENST00000493697.1
ENST00000636057.1
NFIB
nuclear factor I B
chr2_-_69643152 0.67 ENST00000606389.7
AAK1
AP2 associated kinase 1
chr2_-_157444044 0.64 ENST00000264192.8
CYTIP
cytohesin 1 interacting protein
chr2_+_190927649 0.62 ENST00000409428.5
ENST00000409215.5
GLS
glutaminase
chr13_+_35476740 0.59 ENST00000537702.5
NBEA
neurobeachin
chr10_+_18260715 0.59 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr3_+_108822759 0.56 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr3_+_108822778 0.56 ENST00000295756.11
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_-_31919093 0.53 ENST00000602683.5
ENST00000470404.5
PTP4A2
protein tyrosine phosphatase 4A2
chr14_-_70416994 0.52 ENST00000621525.4
ENST00000256366.6
SYNJ2BP-COX16
SYNJ2BP
SYNJ2BP-COX16 readthrough
synaptojanin 2 binding protein
chr12_+_53454718 0.51 ENST00000552819.5
ENST00000455667.7
PCBP2
poly(rC) binding protein 2
chr18_-_28036585 0.50 ENST00000399380.7
CDH2
cadherin 2
chr6_-_110815152 0.49 ENST00000413605.6
CDK19
cyclin dependent kinase 19
chr15_-_43584864 0.46 ENST00000381885.5
ENST00000396923.7
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr6_-_111483700 0.46 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr10_-_97445850 0.45 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
EXOSC1
exosome component 1
chr17_+_70104848 0.42 ENST00000392670.5
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr6_-_110815408 0.41 ENST00000368911.8
CDK19
cyclin dependent kinase 19
chr9_+_122371014 0.38 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr16_+_28494634 0.37 ENST00000564831.6
ENST00000431282.2
APOBR
apolipoprotein B receptor
chr12_-_30735014 0.35 ENST00000433722.6
CAPRIN2
caprin family member 2
chr3_-_11568764 0.34 ENST00000424529.6
VGLL4
vestigial like family member 4
chr15_-_34583592 0.31 ENST00000683415.1
GOLGA8B
golgin A8 family member B
chr4_+_168497044 0.31 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr4_+_168497066 0.28 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr1_-_244862381 0.28 ENST00000640001.1
ENST00000639628.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr12_-_118359105 0.25 ENST00000541186.5
ENST00000539872.5
TAOK3
TAO kinase 3
chr5_-_141618957 0.23 ENST00000389054.8
DIAPH1
diaphanous related formin 1
chr5_-_141619049 0.22 ENST00000647433.1
ENST00000253811.10
ENST00000389057.9
ENST00000398557.8
DIAPH1
diaphanous related formin 1
chr8_+_22999535 0.21 ENST00000251822.7
RHOBTB2
Rho related BTB domain containing 2
chr3_-_79767987 0.20 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr17_-_41424583 0.18 ENST00000225550.4
KRT37
keratin 37
chr5_+_67004618 0.18 ENST00000261569.11
ENST00000436277.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr19_-_35812838 0.18 ENST00000653904.2
PRODH2
proline dehydrogenase 2
chr4_-_47981535 0.18 ENST00000402813.9
CNGA1
cyclic nucleotide gated channel subunit alpha 1
chr6_-_73521783 0.16 ENST00000331523.7
ENST00000356303.7
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr17_-_7929793 0.15 ENST00000303790.3
KCNAB3
potassium voltage-gated channel subfamily A regulatory beta subunit 3
chr2_+_44275473 0.14 ENST00000260649.11
SLC3A1
solute carrier family 3 member 1
chr11_+_72114840 0.14 ENST00000622388.4
FOLR3
folate receptor gamma
chr6_+_10521337 0.13 ENST00000495262.7
GCNT2
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr11_+_31509744 0.12 ENST00000639878.1
ENST00000379163.10
ENST00000638347.1
ENST00000350638.10
ENST00000638764.1
ENST00000639570.1
ENST00000640533.1
ENST00000638482.1
ENST00000640961.2
ENST00000640342.1
ENST00000640231.1
ENST00000640954.1
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr17_-_81656532 0.10 ENST00000331056.10
PDE6G
phosphodiesterase 6G
chr12_+_56116584 0.07 ENST00000501597.3
RPL41
ribosomal protein L41
chr12_+_56116623 0.05 ENST00000546591.6
RPL41
ribosomal protein L41
chrX_-_100732100 0.03 ENST00000372981.1
ENST00000263033.9
SYTL4
synaptotagmin like 4
chr12_+_53454764 0.03 ENST00000439930.7
ENST00000548933.5
PCBP2
poly(rC) binding protein 2
chr18_-_74291924 0.02 ENST00000494131.6
ENST00000340533.9
ENST00000397914.4
CYB5A
cytochrome b5 type A
chr15_+_45252228 0.01 ENST00000560438.5
ENST00000347644.8
SLC28A2
solute carrier family 28 member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.6 16.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.5 1.5 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.4 1.1 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.4 2.2 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.3 2.8 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 0.8 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 4.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 0.7 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.2 3.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 3.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.6 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.7 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.2 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.1 0.6 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 7.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.7 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.5 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.7 GO:0035878 nail development(GO:0035878)
0.0 0.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.8 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 1.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.5 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.7 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.4 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.8 GO:0008542 visual learning(GO:0008542)
0.0 0.5 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 17.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 7.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 4.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.5 GO:0016342 catenin complex(GO:0016342)
0.0 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 2.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 16.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 5.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 1.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2 0.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.7 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 3.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.8 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.6 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.5 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 1.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.8 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.5 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1 0.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 2.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 2.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.4 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.7 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 2.2 GO:0008009 chemokine activity(GO:0008009)
0.0 0.8 GO:0031005 filamin binding(GO:0031005)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 2.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.5 GO:0004532 exoribonuclease activity(GO:0004532)
0.0 0.3 GO:0070034 telomerase RNA binding(GO:0070034)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 2.3 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.7 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 7.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 1.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 4.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions