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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for POU6F1

Z-value: 3.30

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.17 POU6F1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg38_v1_chr12_-_51217671_51217827-0.547.3e-18Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_+_97960192 19.15 ENST00000496368.6
ENST00000421861.7
ENST00000357602.7
IPO5
importin 5
chr15_-_84716063 13.81 ENST00000558217.5
ENST00000558196.1
ENST00000558134.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr15_-_84716099 13.48 ENST00000560266.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr15_-_84716129 12.84 ENST00000268220.12
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr15_-_84716153 12.79 ENST00000455959.7
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr1_-_197146620 12.18 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chrX_-_123622809 12.01 ENST00000441692.5
THOC2
THO complex 2
chrX_+_120604084 11.95 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr2_+_241350087 11.42 ENST00000451310.1
SEPTIN2
septin 2
chr1_-_197146688 11.40 ENST00000294732.11
ASPM
assembly factor for spindle microtubules
chr13_+_30422487 10.50 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr6_-_73521783 8.58 ENST00000331523.7
ENST00000356303.7
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr5_+_163437569 7.96 ENST00000512163.5
ENST00000393929.5
ENST00000510097.5
ENST00000340828.7
ENST00000511490.4
ENST00000510664.5
CCNG1
cyclin G1
chr11_-_107858777 7.66 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr20_+_35542038 7.63 ENST00000357394.8
ENST00000348547.7
ENST00000416206.5
ENST00000640748.1
ENST00000411577.5
ENST00000413587.5
ERGIC3
ERGIC and golgi 3
chr12_-_30735014 7.35 ENST00000433722.6
CAPRIN2
caprin family member 2
chr11_+_85628573 7.01 ENST00000393375.5
ENST00000358867.11
ENST00000534341.1
ENST00000531274.1
TMEM126B
transmembrane protein 126B
chr11_-_33717409 6.70 ENST00000651485.1
CD59
CD59 molecule (CD59 blood group)
chr6_+_151325665 6.51 ENST00000354675.10
AKAP12
A-kinase anchoring protein 12
chr6_-_111483700 6.34 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr11_+_124241095 6.07 ENST00000641972.1
OR8G1
olfactory receptor family 8 subfamily G member 1
chr6_+_63521738 6.07 ENST00000648894.1
ENST00000639568.2
PTP4A1
protein tyrosine phosphatase 4A1
chrX_-_123623155 5.70 ENST00000618150.4
THOC2
THO complex 2
chr6_+_26183750 4.88 ENST00000614097.3
H2BC6
H2B clustered histone 6
chr22_-_28306645 4.50 ENST00000612946.4
TTC28
tetratricopeptide repeat domain 28
chr5_-_144170607 4.21 ENST00000448443.6
ENST00000513112.5
ENST00000519064.5
ENST00000274496.10
ENST00000522203.5
YIPF5
Yip1 domain family member 5
chr2_-_202911621 3.98 ENST00000261015.5
WDR12
WD repeat domain 12
chr8_-_89984609 3.86 ENST00000519426.5
ENST00000265433.8
NBN
nibrin
chr1_+_207325629 3.85 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr17_-_28645108 3.65 ENST00000528896.7
KIAA0100
KIAA0100
chr22_+_31122923 3.44 ENST00000620191.4
ENST00000412277.6
ENST00000412985.5
ENST00000331075.10
ENST00000420017.5
ENST00000400294.6
ENST00000405300.5
ENST00000404390.7
INPP5J
inositol polyphosphate-5-phosphatase J
chr1_-_151459169 3.32 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
POGZ
pogo transposable element derived with ZNF domain
chr11_-_65614195 2.70 ENST00000309100.8
ENST00000529839.1
ENST00000526293.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr9_-_13165442 2.51 ENST00000542239.1
ENST00000538841.5
ENST00000433359.6
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr2_+_127645864 2.46 ENST00000544369.5
GPR17
G protein-coupled receptor 17
chr22_+_22704265 2.30 ENST00000390307.2
IGLV3-22
immunoglobulin lambda variable 3-22
chr2_+_127646145 2.28 ENST00000486700.2
ENST00000272644.7
GPR17
G protein-coupled receptor 17
chr2_+_102104563 2.05 ENST00000409589.5
ENST00000409329.5
IL1R1
interleukin 1 receptor type 1
chr1_-_151459471 2.03 ENST00000271715.7
POGZ
pogo transposable element derived with ZNF domain
chr1_-_21050952 1.93 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr12_+_15546344 1.73 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chr1_+_99646025 1.69 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
PALMD
palmdelphin
chr11_+_31650024 1.63 ENST00000638317.1
ELP4
elongator acetyltransferase complex subunit 4
chr5_+_68290637 1.61 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr8_-_144950813 1.59 ENST00000532351.5
ENST00000394909.7
ENST00000276816.8
ENST00000611477.1
ZNF16
zinc finger protein 16
chr19_+_51573171 1.58 ENST00000436511.2
ZNF175
zinc finger protein 175
chr12_+_102120172 1.56 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARPBP
PARP1 binding protein
chr11_-_2301859 1.33 ENST00000456145.2
ENST00000381153.8
C11orf21
chromosome 11 open reading frame 21
chr12_-_91153149 1.21 ENST00000550758.1
DCN
decorin
chr3_-_114624921 1.21 ENST00000393785.6
ZBTB20
zinc finger and BTB domain containing 20
chr14_-_70416994 1.09 ENST00000621525.4
ENST00000256366.6
SYNJ2BP-COX16
SYNJ2BP
SYNJ2BP-COX16 readthrough
synaptojanin 2 binding protein
chr3_-_114624979 1.04 ENST00000676079.1
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_16916400 0.95 ENST00000513882.5
MYO10
myosin X
chr18_+_9474994 0.87 ENST00000019317.8
RALBP1
ralA binding protein 1
chr17_-_41521719 0.82 ENST00000393976.6
KRT15
keratin 15
chr11_-_89490715 0.80 ENST00000528341.5
NOX4
NADPH oxidase 4
chr15_-_52191387 0.79 ENST00000261837.12
GNB5
G protein subunit beta 5
chr19_-_3786254 0.76 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chr9_-_114806031 0.62 ENST00000374045.5
TNFSF15
TNF superfamily member 15
chr3_-_108529322 0.52 ENST00000273353.4
MYH15
myosin heavy chain 15
chr16_-_87317416 0.47 ENST00000253461.8
ENST00000618367.4
C16orf95
chromosome 16 open reading frame 95
chr16_-_87317364 0.41 ENST00000567970.2
C16orf95
chromosome 16 open reading frame 95
chr15_+_58987652 0.41 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr22_-_21952827 0.40 ENST00000397495.8
ENST00000263212.10
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr19_-_35563653 0.27 ENST00000262623.4
ATP4A
ATPase H+/K+ transporting subunit alpha
chr20_-_59940289 0.27 ENST00000370996.5
PPP1R3D
protein phosphatase 1 regulatory subunit 3D
chr11_-_89491131 0.20 ENST00000343727.9
ENST00000531342.5
ENST00000375979.7
NOX4
NADPH oxidase 4
chr16_+_15650221 0.18 ENST00000396354.6
ENST00000570727.5
ENST00000674581.1
ENST00000674995.1
NDE1
nudE neurodevelopment protein 1
chr12_-_108561157 0.06 ENST00000228284.8
ENST00000431469.6
ENST00000546815.6
SART3
spliceosome associated factor 3, U4/U6 recycling protein
chr5_+_42548043 0.05 ENST00000618088.4
ENST00000612382.4
GHR
growth hormone receptor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 23.6 GO:0009786 regulation of asymmetric cell division(GO:0009786)
3.0 11.9 GO:0002188 translation reinitiation(GO:0002188)
1.8 52.9 GO:0006465 signal peptide processing(GO:0006465)
1.5 17.7 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
1.3 6.7 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
1.3 19.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.8 3.9 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.7 2.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.6 3.9 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.5 6.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.4 1.7 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.4 8.6 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.4 4.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.3 4.7 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.3 2.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 5.4 GO:0051382 kinetochore assembly(GO:0051382)
0.3 4.0 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 6.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 3.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 1.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.4 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 7.0 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 1.6 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 1.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 3.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 1.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 8.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 6.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 6.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.8 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 1.0 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 1.9 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 1.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.3 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.2 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 1.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 2.3 GO:0002377 immunoglobulin production(GO:0002377)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 52.9 GO:0005787 signal peptidase complex(GO:0005787)
2.6 23.6 GO:0036449 microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687)
2.0 17.7 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.8 8.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.7 4.0 GO:0070545 PeBoW complex(GO:0070545)
0.4 1.6 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.4 6.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.4 3.9 GO:0030870 Mre11 complex(GO:0030870)
0.3 6.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 11.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 1.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 19.1 GO:0005643 nuclear pore(GO:0005643)
0.1 1.6 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 4.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 2.5 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 11.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 1.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 3.4 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.0 GO:0032433 filopodium tip(GO:0032433)
0.0 1.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 10.8 GO:0005819 spindle(GO:0005819)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 10.0 GO:0005813 centrosome(GO:0005813)
0.0 1.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.0 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.0 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 5.2 GO:0005938 cell cortex(GO:0005938)
0.0 2.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 7.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 5.4 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 19.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.7 2.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.6 6.1 GO:0005549 odorant binding(GO:0005549)
0.5 2.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.4 6.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 3.4 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.3 8.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 6.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 6.7 GO:0001848 complement binding(GO:0001848)
0.2 13.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.6 GO:0046935 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 52.9 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 1.0 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 1.6 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 1.0 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 6.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 4.6 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.1 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.3 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1 22.7 GO:0005516 calmodulin binding(GO:0005516)
0.1 3.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 11.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 3.9 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.8 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 2.0 GO:0003823 antigen binding(GO:0003823)
0.0 3.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.6 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 3.9 PID ATM PATHWAY ATM pathway
0.1 4.3 PID REELIN PATHWAY Reelin signaling pathway
0.1 8.0 PID P53 REGULATION PATHWAY p53 pathway
0.1 3.9 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 2.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 52.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
1.1 8.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 4.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 3.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 3.9 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 19.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 5.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 6.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 2.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.9 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling