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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for POU6F2

Z-value: 4.29

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Transcription factors associated with POU6F2

Gene Symbol Gene ID Gene Info
POU6F2
ENSG00000106536.21 POU6F2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F2hg38_v1_chr7_+_38977904_389780090.409.2e-10Click!

Activity profile of POU6F2 motif

Sorted Z-values of POU6F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_16606102 31.68 ENST00000537304.6
LMO3
LIM domain only 3
chr12_-_16605939 31.11 ENST00000541295.5
ENST00000535535.5
LMO3
LIM domain only 3
chrX_-_13817027 25.51 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
GPM6B
glycoprotein M6B
chr6_+_121437378 24.24 ENST00000650427.1
ENST00000647564.1
GJA1
gap junction protein alpha 1
chr1_+_50106265 23.04 ENST00000357083.8
ELAVL4
ELAV like RNA binding protein 4
chr2_+_200440649 21.27 ENST00000366118.2
SPATS2L
spermatogenesis associated serine rich 2 like
chr5_-_135578983 20.86 ENST00000512158.6
CXCL14
C-X-C motif chemokine ligand 14
chr14_-_20436161 19.60 ENST00000636854.3
KLHL33
kelch like family member 33
chr2_-_2324323 19.59 ENST00000648339.1
ENST00000647694.1
MYT1L
myelin transcription factor 1 like
chr4_+_112860981 19.34 ENST00000671704.1
ANK2
ankyrin 2
chr4_+_112860912 19.02 ENST00000671951.1
ANK2
ankyrin 2
chr4_+_112861053 18.50 ENST00000672221.1
ANK2
ankyrin 2
chr3_+_159839847 17.85 ENST00000445224.6
SCHIP1
schwannomin interacting protein 1
chr3_+_111999189 17.06 ENST00000455401.6
TAGLN3
transgelin 3
chr3_+_111998739 16.94 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr3_+_111998915 16.03 ENST00000478951.6
TAGLN3
transgelin 3
chr5_+_36606355 15.97 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
SLC1A3
solute carrier family 1 member 3
chr3_+_111999326 15.81 ENST00000494932.1
TAGLN3
transgelin 3
chr6_+_150721073 15.10 ENST00000358517.6
PLEKHG1
pleckstrin homology and RhoGEF domain containing G1
chr1_+_50105666 14.06 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr14_-_26598025 13.28 ENST00000539517.7
NOVA1
NOVA alternative splicing regulator 1
chr12_-_16608073 12.85 ENST00000441439.6
LMO3
LIM domain only 3
chr12_-_16608183 12.08 ENST00000354662.5
ENST00000538051.5
LMO3
LIM domain only 3
chr11_-_129192198 12.03 ENST00000310343.13
ARHGAP32
Rho GTPase activating protein 32
chr14_+_22515623 10.99 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr4_-_86360010 10.29 ENST00000641911.1
ENST00000641072.1
ENST00000359221.8
ENST00000640490.1
MAPK10
mitogen-activated protein kinase 10
chr11_-_129192291 10.05 ENST00000682385.1
ARHGAP32
Rho GTPase activating protein 32
chr3_-_127822455 9.81 ENST00000265052.10
MGLL
monoglyceride lipase
chr9_-_76906041 9.76 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
PRUNE2
prune homolog 2 with BCH domain
chr20_+_59940362 9.72 ENST00000360816.8
FAM217B
family with sequence similarity 217 member B
chr1_+_50108856 9.67 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAVL4
ELAV like RNA binding protein 4
chr10_+_18260715 9.56 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr10_-_121596117 9.18 ENST00000351936.11
FGFR2
fibroblast growth factor receptor 2
chr3_+_189789672 9.11 ENST00000434928.5
TP63
tumor protein p63
chr6_+_151325665 8.92 ENST00000354675.10
AKAP12
A-kinase anchoring protein 12
chr2_-_2326378 8.71 ENST00000647618.1
MYT1L
myelin transcription factor 1 like
chr9_-_76906090 8.28 ENST00000376718.8
PRUNE2
prune homolog 2 with BCH domain
chr22_-_50085414 8.23 ENST00000311597.10
MLC1
modulator of VRAC current 1
chr22_-_50085331 8.04 ENST00000395876.6
MLC1
modulator of VRAC current 1
chr13_+_57631735 7.93 ENST00000377918.8
PCDH17
protocadherin 17
chr13_-_109786567 7.49 ENST00000375856.5
IRS2
insulin receptor substrate 2
chr10_-_20897288 7.40 ENST00000377122.9
NEBL
nebulette
chr7_-_73624492 7.36 ENST00000414749.6
ENST00000429400.6
ENST00000434326.5
ENST00000313375.8
ENST00000354613.5
ENST00000453275.1
MLXIPL
MLX interacting protein like
chr14_+_19743571 7.35 ENST00000642117.2
OR4Q3
olfactory receptor family 4 subfamily Q member 3
chr14_+_32329256 6.80 ENST00000280979.9
AKAP6
A-kinase anchoring protein 6
chrX_+_43656289 6.55 ENST00000338702.4
MAOA
monoamine oxidase A
chr11_+_45896541 6.53 ENST00000395629.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr6_-_8064333 6.33 ENST00000543936.7
ENST00000397457.7
BLOC1S5
biogenesis of lysosomal organelles complex 1 subunit 5
chr11_+_107591077 6.20 ENST00000531234.5
ENST00000265840.12
ELMOD1
ELMO domain containing 1
chr12_-_30735014 6.02 ENST00000433722.6
CAPRIN2
caprin family member 2
chr3_-_57165332 6.00 ENST00000296318.12
IL17RD
interleukin 17 receptor D
chr5_+_68290637 5.95 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr1_-_158426237 5.79 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr19_+_9178979 5.42 ENST00000642043.1
ENST00000641288.2
OR7D2
olfactory receptor family 7 subfamily D member 2
chrX_-_38327496 5.10 ENST00000642395.2
ENST00000645032.1
ENST00000644238.1
ENST00000642558.1
ENST00000339363.7
ENST00000644337.1
ENST00000647261.1
RPGR
retinitis pigmentosa GTPase regulator
chr11_+_93746433 5.05 ENST00000526335.1
C11orf54
chromosome 11 open reading frame 54
chr4_-_73620629 5.02 ENST00000342081.7
RASSF6
Ras association domain family member 6
chr7_-_126533850 4.99 ENST00000444921.3
GRM8
glutamate metabotropic receptor 8
chr6_-_142946312 4.39 ENST00000367604.6
HIVEP2
HIVEP zinc finger 2
chr5_-_141618914 4.33 ENST00000518047.5
DIAPH1
diaphanous related formin 1
chr11_-_70826887 4.30 ENST00000656230.1
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr4_-_73620391 4.04 ENST00000395777.6
ENST00000307439.10
RASSF6
Ras association domain family member 6
chr6_+_158017048 4.01 ENST00000638626.1
SYNJ2
synaptojanin 2
chr21_-_31160904 3.81 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr15_+_92900189 3.39 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chr14_-_68794597 3.33 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein like 1
chrX_+_108045050 3.18 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr14_+_32329341 3.18 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
AKAP6
A-kinase anchoring protein 6
chr6_+_25754699 3.01 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chrX_-_32412220 2.99 ENST00000619831.5
DMD
dystrophin
chr14_+_94026314 2.94 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr6_-_110815408 2.93 ENST00000368911.8
CDK19
cyclin dependent kinase 19
chrX_+_108044967 2.86 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr9_-_114806031 2.81 ENST00000374045.5
TNFSF15
TNF superfamily member 15
chr21_-_40847149 2.68 ENST00000400454.6
DSCAM
DS cell adhesion molecule
chr7_-_13988863 2.68 ENST00000405358.8
ETV1
ETS variant transcription factor 1
chr7_+_129368123 2.59 ENST00000460109.5
ENST00000474594.5
AHCYL2
adenosylhomocysteinase like 2
chr17_-_41397600 2.49 ENST00000251645.3
KRT31
keratin 31
chr2_+_44275473 2.47 ENST00000260649.11
SLC3A1
solute carrier family 3 member 1
chr20_+_43558968 2.13 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2
chr18_-_55423757 2.03 ENST00000675707.1
TCF4
transcription factor 4
chr9_+_114611206 2.03 ENST00000374049.4
ENST00000288502.9
TMEM268
transmembrane protein 268
chr3_-_101320558 2.02 ENST00000193391.8
IMPG2
interphotoreceptor matrix proteoglycan 2
chr11_+_65787056 1.90 ENST00000335987.8
OVOL1
ovo like transcriptional repressor 1
chrX_+_30235894 1.86 ENST00000620842.1
MAGEB3
MAGE family member B3
chr8_+_76681208 1.71 ENST00000651372.2
ZFHX4
zinc finger homeobox 4
chr17_-_42185452 1.70 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr4_+_87650277 1.69 ENST00000339673.11
ENST00000282479.8
DMP1
dentin matrix acidic phosphoprotein 1
chr12_-_52652207 1.61 ENST00000309680.4
KRT2
keratin 2
chr20_+_57561103 1.56 ENST00000319441.6
PCK1
phosphoenolpyruvate carboxykinase 1
chr5_+_141412979 1.49 ENST00000612503.1
ENST00000398610.3
PCDHGA10
protocadherin gamma subfamily A, 10
chr6_+_50818701 1.42 ENST00000344788.7
TFAP2B
transcription factor AP-2 beta
chr9_-_13165442 1.42 ENST00000542239.1
ENST00000538841.5
ENST00000433359.6
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr15_+_58410543 1.42 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chrX_+_87517784 1.40 ENST00000373119.9
ENST00000373114.4
KLHL4
kelch like family member 4
chr12_-_70637405 1.36 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
PTPRB
protein tyrosine phosphatase receptor type B
chr5_-_157059109 1.22 ENST00000523175.6
ENST00000522693.5
HAVCR1
hepatitis A virus cellular receptor 1
chr6_-_155314444 1.16 ENST00000367166.5
TFB1M
transcription factor B1, mitochondrial
chr2_+_162318884 1.15 ENST00000446271.5
ENST00000429691.6
GCA
grancalcin
chr1_+_177170916 1.11 ENST00000361539.5
BRINP2
BMP/retinoic acid inducible neural specific 2
chr1_-_208244375 1.06 ENST00000367033.4
PLXNA2
plexin A2
chr1_-_204359885 1.05 ENST00000414478.1
ENST00000272203.8
PLEKHA6
pleckstrin homology domain containing A6
chr10_+_119207560 1.04 ENST00000392870.3
GRK5
G protein-coupled receptor kinase 5
chr2_-_68871382 0.84 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chr1_-_21279520 0.80 ENST00000357071.8
ECE1
endothelin converting enzyme 1
chr20_-_46406582 0.75 ENST00000450812.5
ENST00000290246.11
ENST00000396391.5
ELMO2
engulfment and cell motility 2
chr2_-_181680490 0.75 ENST00000684145.1
ENST00000295108.4
ENST00000684079.1
ENST00000683430.1
CERKL
NEUROD1
ceramide kinase like
neuronal differentiation 1
chr17_-_41424583 0.73 ENST00000225550.4
KRT37
keratin 37
chr4_+_109912877 0.65 ENST00000265171.10
ENST00000509793.5
ENST00000652245.1
EGF
epidermal growth factor
chr12_+_15546344 0.65 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chr6_-_110815152 0.64 ENST00000413605.6
CDK19
cyclin dependent kinase 19
chr2_-_55917699 0.56 ENST00000634374.1
EFEMP1
EGF containing fibulin extracellular matrix protein 1
chr17_+_50165990 0.55 ENST00000262018.8
ENST00000344627.10
ENST00000682109.1
ENST00000504073.2
SGCA
sarcoglycan alpha
chrX_+_69616067 0.39 ENST00000338901.4
ENST00000525810.5
ENST00000527388.5
ENST00000374553.6
ENST00000374552.9
ENST00000524573.5
EDA
ectodysplasin A
chr6_-_33192454 0.35 ENST00000395194.1
ENST00000341947.7
ENST00000374708.8
COL11A2
collagen type XI alpha 2 chain
chr13_-_103066411 0.33 ENST00000245312.5
SLC10A2
solute carrier family 10 member 2
chr18_-_13915531 0.16 ENST00000327606.4
MC2R
melanocortin 2 receptor
chr1_+_193059448 0.15 ENST00000432079.5
RO60
Ro60, Y RNA binding protein
chr1_+_175067831 0.10 ENST00000239462.9
TNN
tenascin N
chr6_+_50818857 0.08 ENST00000393655.4
TFAP2B
transcription factor AP-2 beta
chr10_-_73655984 0.05 ENST00000394810.3
SYNPO2L
synaptopodin 2 like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 87.7 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
6.1 24.2 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
5.7 56.9 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.5 20.9 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
2.1 25.5 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.0 8.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
1.7 10.0 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.6 16.0 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.5 9.2 GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
1.4 9.6 GO:1904879 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
1.2 7.5 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
1.1 16.8 GO:0007258 JUN phosphorylation(GO:0007258)
1.1 3.3 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
1.1 9.8 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.1 16.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
1.1 7.4 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
1.0 3.8 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.7 8.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.6 1.9 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.5 21.3 GO:0048665 neuron fate specification(GO:0048665)
0.5 1.6 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.5 1.5 GO:0097272 ammonia homeostasis(GO:0097272)
0.5 7.9 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.4 0.8 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.4 6.5 GO:0042420 dopamine catabolic process(GO:0042420)
0.4 6.3 GO:0050942 positive regulation of pigment cell differentiation(GO:0050942)
0.4 2.5 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.4 6.0 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.3 6.8 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 7.4 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.3 2.9 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.3 5.0 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.2 1.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 3.0 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 2.7 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.2 18.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 1.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.2 1.7 GO:0070166 enamel mineralization(GO:0070166)
0.2 0.7 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.2 0.6 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 0.8 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 6.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 2.8 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 1.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 4.3 GO:0060292 long term synaptic depression(GO:0060292)
0.1 4.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.4 GO:0034638 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.1 2.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 5.1 GO:0042073 intraciliary transport(GO:0042073)
0.1 0.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 1.6 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.4 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 45.6 GO:0006397 mRNA processing(GO:0006397)
0.1 0.5 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 9.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 9.1 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 3.2 GO:0070268 cornification(GO:0070268)
0.0 3.6 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 2.1 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 29.3 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 2.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.0 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
1.3 24.2 GO:0005922 connexon complex(GO:0005922)
1.2 10.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
1.0 59.8 GO:0043034 costamere(GO:0043034)
0.7 6.5 GO:0044294 dendritic growth cone(GO:0044294)
0.5 9.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 6.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 21.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 4.3 GO:0005883 neurofilament(GO:0005883)
0.2 67.2 GO:0043209 myelin sheath(GO:0043209)
0.2 3.8 GO:0044295 axonal growth cone(GO:0044295)
0.2 0.8 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.2 1.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 16.3 GO:0005901 caveola(GO:0005901)
0.1 22.1 GO:0001650 fibrillar center(GO:0001650)
0.1 0.3 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 3.6 GO:0016592 mediator complex(GO:0016592)
0.1 7.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.5 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0 5.1 GO:0036064 ciliary basal body(GO:0036064)
0.0 4.8 GO:0005882 intermediate filament(GO:0005882)
0.0 5.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.5 GO:0031526 brush border membrane(GO:0031526)
0.0 9.2 GO:0045121 membrane raft(GO:0045121)
0.0 6.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.3 GO:0030426 growth cone(GO:0030426)
0.0 17.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 8.5 GO:0043235 receptor complex(GO:0043235)
0.0 7.1 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 4.1 GO:0060076 excitatory synapse(GO:0060076)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 8.0 GO:0043005 neuron projection(GO:0043005)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.2 GO:0031514 motile cilium(GO:0031514)
0.0 0.9 GO:0030018 Z disc(GO:0030018)
0.0 1.2 GO:0035578 azurophil granule lumen(GO:0035578)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 24.2 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
1.2 50.1 GO:0017091 AU-rich element binding(GO:0017091)
1.1 16.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.0 18.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.9 56.9 GO:0030507 spectrin binding(GO:0030507)
0.9 6.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.8 10.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.8 9.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.7 9.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.7 6.0 GO:0046935 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.7 6.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.7 9.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.6 8.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.6 4.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.5 1.6 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.5 6.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 4.0 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.4 20.9 GO:0008009 chemokine activity(GO:0008009)
0.4 2.5 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.3 7.5 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 2.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.3 7.4 GO:0031005 filamin binding(GO:0031005)
0.3 0.6 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.3 65.8 GO:0051015 actin filament binding(GO:0051015)
0.2 1.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 18.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 1.0 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.2 18.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 30.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.0 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 1.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 3.0 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 5.0 GO:0008066 glutamate receptor activity(GO:0008066)
0.1 2.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.8 GO:0031433 telethonin binding(GO:0031433)
0.1 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 2.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 28.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.7 GO:0046625 sphingolipid binding(GO:0046625)
0.1 3.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.0 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 1.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 3.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 2.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 20.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.7 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 3.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 2.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 72.1 GO:0046872 metal ion binding(GO:0046872)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 4.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 30.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.3 16.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 25.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 7.5 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.2 15.2 PID FGF PATHWAY FGF signaling pathway
0.1 7.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 11.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 24.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.4 7.5 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.4 9.2 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.4 10.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 6.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.3 6.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 5.0 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 9.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2 9.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 18.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 18.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 2.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 3.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 0.7 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 1.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 4.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 7.4 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 3.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.8 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 3.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts