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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PPARD

Z-value: 0.70

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.14 PPARD

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg38_v1_chr6_+_35342535_35342582-0.306.3e-06Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_32038382 5.19 ENST00000478281.5
ENST00000471671.4
ENST00000435122.3
ENST00000644719.2
CYP21A2
cytochrome P450 family 21 subfamily A member 2
chr1_-_161223559 4.61 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr1_-_161223408 4.57 ENST00000491350.1
APOA2
apolipoprotein A2
chr17_+_7219857 4.41 ENST00000583312.5
ENST00000350303.9
ENST00000584103.5
ENST00000356839.10
ENST00000579886.2
ACADVL
acyl-CoA dehydrogenase very long chain
chr4_+_139665768 4.10 ENST00000616265.4
ENST00000265498.6
ENST00000506797.5
MGST2
microsomal glutathione S-transferase 2
chr1_-_119768892 3.89 ENST00000369406.8
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2
chr19_-_51366338 3.86 ENST00000596253.1
ENST00000309244.9
ETFB
electron transfer flavoprotein subunit beta
chr7_-_87713287 3.78 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ABCB1
ATP binding cassette subfamily B member 1
chr2_+_218419114 3.77 ENST00000454069.5
ENST00000392114.6
ENST00000248444.10
VIL1
villin 1
chr2_-_197499826 3.30 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
HSPD1
heat shock protein family D (Hsp60) member 1
chr2_-_197499857 3.12 ENST00000428204.6
ENST00000678170.1
ENST00000676933.1
ENST00000678621.1
HSPD1
heat shock protein family D (Hsp60) member 1
chr2_+_119367669 3.00 ENST00000393103.2
DBI
diazepam binding inhibitor, acyl-CoA binding protein
chr18_-_49813512 2.93 ENST00000285093.15
ACAA2
acetyl-CoA acyltransferase 2
chr2_+_197500371 2.92 ENST00000409468.1
ENST00000233893.10
HSPE1
heat shock protein family E (Hsp10) member 1
chr6_+_33204645 2.73 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr12_-_52926459 2.69 ENST00000552150.5
KRT8
keratin 8
chr4_-_7068033 2.44 ENST00000264954.5
GRPEL1
GrpE like 1, mitochondrial
chr22_-_50578417 2.33 ENST00000312108.12
ENST00000395650.6
CPT1B
carnitine palmitoyltransferase 1B
chr15_+_43593054 2.22 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
CKMT1B
creatine kinase, mitochondrial 1B
chr11_+_34438900 2.18 ENST00000241052.5
CAT
catalase
chr1_-_145707387 2.16 ENST00000451928.6
PDZK1
PDZ domain containing 1
chr1_-_145707345 2.12 ENST00000417171.6
PDZK1
PDZ domain containing 1
chr2_+_197500398 2.08 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chrX_+_2828921 2.04 ENST00000398806.8
GYG2
glycogenin 2
chr2_-_206159509 1.98 ENST00000423725.5
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr8_-_80029826 1.97 ENST00000519386.5
MRPS28
mitochondrial ribosomal protein S28
chr8_-_80029904 1.96 ENST00000521434.5
ENST00000519120.1
ENST00000520946.1
MRPS28
mitochondrial ribosomal protein S28
chr6_+_43298254 1.89 ENST00000372585.10
ENST00000449231.5
ENST00000372589.7
SLC22A7
solute carrier family 22 member 7
chr12_-_56333693 1.83 ENST00000425394.7
ENST00000548043.5
PAN2
poly(A) specific ribonuclease subunit PAN2
chr12_+_95858928 1.83 ENST00000266735.9
ENST00000553192.5
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr17_+_39737923 1.80 ENST00000577695.5
ENST00000309156.9
GRB7
growth factor receptor bound protein 7
chr8_-_80030232 1.73 ENST00000518271.1
ENST00000276585.9
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr15_+_43692886 1.72 ENST00000434505.5
ENST00000411750.5
CKMT1A
creatine kinase, mitochondrial 1A
chr12_-_56333893 1.71 ENST00000547572.1
ENST00000257931.9
ENST00000610546.4
ENST00000440411.7
PAN2
poly(A) specific ribonuclease subunit PAN2
chrX_+_2828808 1.70 ENST00000381163.7
GYG2
glycogenin 2
chr3_+_186666003 1.70 ENST00000232003.5
HRG
histidine rich glycoprotein
chr10_-_95069489 1.67 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
CYP2C8
cytochrome P450 family 2 subfamily C member 8
chr3_-_58537181 1.67 ENST00000302819.10
ACOX2
acyl-CoA oxidase 2
chr3_-_58537283 1.65 ENST00000459701.6
ACOX2
acyl-CoA oxidase 2
chr17_-_36001549 1.63 ENST00000617897.2
CCL15
C-C motif chemokine ligand 15
chr1_+_165895583 1.51 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr2_-_206159410 1.48 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr1_+_165895564 1.44 ENST00000469256.6
UCK2
uridine-cytidine kinase 2
chr9_-_33402551 1.44 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
AQP7
aquaporin 7
chr22_+_29767351 1.43 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr18_-_49813869 1.43 ENST00000586485.5
ENST00000587994.5
ENST00000586100.1
ACAA2
acetyl-CoA acyltransferase 2
chr2_-_27890348 1.42 ENST00000302188.8
RBKS
ribokinase
chr1_+_54641806 1.38 ENST00000409996.5
MROH7
maestro heat like repeat family member 7
chr16_-_4351257 1.34 ENST00000577031.5
PAM16
presequence translocase associated motor 16
chr22_-_42130800 1.34 ENST00000645361.2
ENST00000359033.4
CYP2D6
cytochrome P450 family 2 subfamily D member 6
chr16_-_4351283 1.34 ENST00000318059.8
PAM16
presequence translocase associated motor 16
chr9_-_33402449 1.31 ENST00000377425.8
AQP7
aquaporin 7
chr1_-_156705764 1.30 ENST00000621784.4
ENST00000368220.1
CRABP2
cellular retinoic acid binding protein 2
chr17_+_7580442 1.27 ENST00000584180.1
CD68
CD68 molecule
chr1_+_54641754 1.24 ENST00000339553.9
ENST00000421030.7
MROH7
maestro heat like repeat family member 7
chr6_+_43298326 1.14 ENST00000372574.7
SLC22A7
solute carrier family 22 member 7
chr2_+_177392734 1.09 ENST00000680770.1
ENST00000637633.2
ENST00000679459.1
ENST00000409888.1
ENST00000264167.11
ENST00000642466.2
AGPS
alkylglycerone phosphate synthase
chr21_-_25735570 1.09 ENST00000400090.7
ENST00000400087.7
ENST00000400093.3
ATP5PF
ATP synthase peripheral stalk subunit F6
chr20_+_48921701 1.07 ENST00000371917.5
ARFGEF2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr15_-_82262660 1.06 ENST00000557844.1
ENST00000359445.7
ENST00000268206.12
EFL1
elongation factor like GTPase 1
chr9_+_112380080 1.05 ENST00000398803.1
ENST00000398805.8
HSDL2
hydroxysteroid dehydrogenase like 2
chr19_-_10577231 1.02 ENST00000589348.1
ENST00000592285.1
ENST00000587069.5
AP1M2
adaptor related protein complex 1 subunit mu 2
chr17_-_35943707 0.98 ENST00000615905.5
LYZL6
lysozyme like 6
chr4_+_158672237 0.98 ENST00000682734.1
ETFDH
electron transfer flavoprotein dehydrogenase
chr17_-_35943662 0.94 ENST00000618542.4
LYZL6
lysozyme like 6
chr12_+_120725796 0.85 ENST00000242592.9
ENST00000411593.2
ACADS
acyl-CoA dehydrogenase short chain
chr3_-_48898813 0.85 ENST00000319017.5
ENST00000430379.5
SLC25A20
solute carrier family 25 member 20
chr19_+_49363923 0.85 ENST00000597546.1
DKKL1
dickkopf like acrosomal protein 1
chr13_+_113105782 0.80 ENST00000541084.5
ENST00000346342.8
ENST00000375581.3
F7
coagulation factor VII
chr1_-_109426410 0.78 ENST00000271308.9
PSMA5
proteasome 20S subunit alpha 5
chr17_-_41572052 0.78 ENST00000588431.1
ENST00000246662.9
KRT9
keratin 9
chr20_+_43558968 0.77 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2
chr7_+_7182526 0.75 ENST00000436587.7
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
chr4_+_158672266 0.74 ENST00000684622.1
ENST00000683483.1
ENST00000684641.1
ENST00000682456.1
ENST00000684627.1
ENST00000511912.6
ENST00000684505.1
ENST00000683305.1
ENST00000684036.1
ENST00000683751.1
ENST00000684129.1
ENST00000307738.5
ETFDH
electron transfer flavoprotein dehydrogenase
chr5_-_16508858 0.71 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr5_-_16508951 0.71 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr1_+_61952036 0.70 ENST00000646453.1
ENST00000635137.1
PATJ
PATJ crumbs cell polarity complex component
chr21_-_25734887 0.69 ENST00000400094.5
ENST00000284971.8
ATP5PF
ATP synthase peripheral stalk subunit F6
chr21_-_25735026 0.69 ENST00000400099.5
ENST00000457143.6
ATP5PF
ATP synthase peripheral stalk subunit F6
chr1_-_160862880 0.68 ENST00000368034.9
CD244
CD244 molecule
chr1_-_11047225 0.67 ENST00000400898.3
ENST00000400897.8
MASP2
mannan binding lectin serine peptidase 2
chr5_-_16508812 0.67 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr4_+_173168800 0.67 ENST00000512285.5
ENST00000265000.9
GALNT7
polypeptide N-acetylgalactosaminyltransferase 7
chr1_+_61952283 0.65 ENST00000307297.8
PATJ
PATJ crumbs cell polarity complex component
chrX_-_109625161 0.60 ENST00000372101.3
KCNE5
potassium voltage-gated channel subfamily E regulatory subunit 5
chr2_+_206159580 0.59 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_+_206159884 0.57 ENST00000392222.7
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr6_+_72212802 0.54 ENST00000401910.7
RIMS1
regulating synaptic membrane exocytosis 1
chr6_-_33580229 0.50 ENST00000374467.4
ENST00000442998.6
ENST00000360661.9
BAK1
BCL2 antagonist/killer 1
chr11_+_64306227 0.45 ENST00000405666.5
ENST00000468670.2
ESRRA
estrogen related receptor alpha
chr14_-_24576240 0.43 ENST00000216336.3
CTSG
cathepsin G
chr6_-_32109291 0.40 ENST00000479795.1
ENST00000647633.1
ENST00000644971.2
ENST00000375244.7
TNXB
tenascin XB
chr6_+_72212887 0.39 ENST00000523963.5
RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_92291155 0.38 ENST00000358935.3
MARCHF5
membrane associated ring-CH-type finger 5
chr2_-_64019367 0.37 ENST00000272322.9
VPS54
VPS54 subunit of GARP complex
chr1_-_161132577 0.36 ENST00000464113.1
DEDD
death effector domain containing
chr17_+_76001338 0.33 ENST00000425876.6
CDK3
cyclin dependent kinase 3
chr2_+_205682491 0.32 ENST00000360409.7
ENST00000450507.5
ENST00000357785.10
ENST00000417189.5
NRP2
neuropilin 2
chr3_-_125375249 0.22 ENST00000484491.5
ENST00000492394.5
ENST00000471196.1
ENST00000468369.5
ENST00000485866.5
ENST00000360647.9
ZNF148
zinc finger protein 148
chr5_-_16508990 0.20 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr16_-_74774812 0.20 ENST00000219368.8
FA2H
fatty acid 2-hydroxylase
chr17_+_50532713 0.15 ENST00000503690.5
ENST00000514874.5
ENST00000268933.8
EPN3
epsin 3
chr17_+_76000906 0.15 ENST00000448471.2
CDK3
cyclin dependent kinase 3
chrX_+_38352573 0.15 ENST00000039007.5
OTC
ornithine transcarbamylase
chr3_-_187291882 0.13 ENST00000392470.6
ENST00000169293.10
ENST00000439271.1
ENST00000392472.6
ENST00000392475.2
MASP1
mannan binding lectin serine peptidase 1
chr20_-_63499074 0.13 ENST00000217182.6
ENST00000642899.1
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr1_-_161132659 0.13 ENST00000368006.8
ENST00000490843.6
ENST00000545495.5
DEDD
death effector domain containing
chr3_-_187291680 0.12 ENST00000425937.1
ENST00000337774.10
ENST00000296280.11
MASP1
mannan binding lectin serine peptidase 1
chr15_+_75201873 0.11 ENST00000394987.5
C15orf39
chromosome 15 open reading frame 39
chr1_+_8945858 0.09 ENST00000549778.5
ENST00000377443.7
ENST00000480186.7
ENST00000377436.6
ENST00000377442.3
CA6
carbonic anhydrase 6
chr5_-_16508788 0.08 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr17_-_36017953 0.08 ENST00000612516.4
ENST00000615050.2
CCL23
C-C motif chemokine ligand 23
chr12_+_59664677 0.08 ENST00000548610.5
SLC16A7
solute carrier family 16 member 7
chr3_+_48465811 0.07 ENST00000433541.1
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr19_+_10086305 0.07 ENST00000253110.16
ENST00000591813.5
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chr6_+_143677935 0.05 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
PHACTR2
phosphatase and actin regulator 2
chr10_-_92291063 0.03 ENST00000265997.5
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr6_+_87590067 0.02 ENST00000546266.5
ENST00000257789.4
ENST00000392844.8
ORC3
origin recognition complex subunit 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.2 GO:2000910 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
2.1 6.4 GO:0002368 B cell cytokine production(GO:0002368)
0.9 3.8 GO:0060327 cytoplasmic actin-based contraction involved in cell motility(GO:0060327)
0.7 2.9 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.7 13.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.6 4.4 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.5 3.8 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.5 2.8 GO:0015793 glycerol transport(GO:0015793)
0.4 2.2 GO:0010193 response to ozone(GO:0010193)
0.4 1.7 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.4 1.7 GO:0002933 lipid hydroxylation(GO:0002933)
0.4 1.9 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.4 1.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.4 3.9 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.3 1.3 GO:0009822 alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076)
0.3 5.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.3 2.4 GO:0061709 reticulophagy(GO:0061709)
0.3 5.2 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.3 7.5 GO:0015879 carnitine transport(GO:0015879)
0.3 1.4 GO:0019323 pentose catabolic process(GO:0019323)
0.3 0.5 GO:0002339 B cell selection(GO:0002339)
0.2 0.7 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.2 0.8 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.2 2.7 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.2 2.6 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 3.5 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.2 1.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.2 3.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.9 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 1.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 1.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 1.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 3.7 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 3.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 3.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 1.8 GO:0034063 stress granule assembly(GO:0034063)
0.1 5.7 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.8 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 0.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.4 GO:0070943 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.1 0.5 GO:0045023 G0 to G1 transition(GO:0045023)
0.1 3.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.1 GO:0097272 ammonia homeostasis(GO:0097272)
0.0 0.9 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.8 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 1.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.3 GO:0097490 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 1.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 1.3 GO:0006414 translational elongation(GO:0006414)
0.0 1.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.8 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.7 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.5 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
1.2 3.5 GO:0031251 PAN complex(GO:0031251)
0.7 6.4 GO:0046696 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) lipopolysaccharide receptor complex(GO:0046696)
0.7 3.5 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.6 9.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.3 1.8 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.2 5.7 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 3.8 GO:0032433 filopodium tip(GO:0032433)
0.2 1.1 GO:0005879 axonemal microtubule(GO:0005879) asymmetric synapse(GO:0032279)
0.2 1.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 4.3 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 6.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 4.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 2.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.7 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 1.7 GO:0036019 endolysosome(GO:0036019)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 18.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.4 GO:0000938 GARP complex(GO:0000938)
0.0 2.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 2.3 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.3 3.9 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
1.3 3.8 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
1.2 3.7 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.1 4.4 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
1.1 4.3 GO:0005124 scavenger receptor binding(GO:0005124)
1.1 6.4 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.0 3.0 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.8 4.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.7 2.8 GO:0015254 glycerol channel activity(GO:0015254)
0.7 2.7 GO:0070404 NADH binding(GO:0070404)
0.6 3.3 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.5 2.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.4 4.4 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.4 2.9 GO:0004849 uridine kinase activity(GO:0004849)
0.4 3.8 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.4 2.2 GO:0004046 aminoacylase activity(GO:0004046)
0.3 1.7 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.3 1.9 GO:0003796 lysozyme activity(GO:0003796)
0.3 0.8 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.2 1.7 GO:0048039 ubiquinone binding(GO:0048039)
0.2 1.7 GO:0004111 creatine kinase activity(GO:0004111)
0.2 6.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 1.4 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 3.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 2.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 3.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 0.7 GO:0001855 complement component C4b binding(GO:0001855)
0.1 3.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 2.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.8 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 1.3 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1 1.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.1 GO:0071949 FAD binding(GO:0071949)
0.0 0.8 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 3.9 GO:0009055 electron carrier activity(GO:0009055)
0.0 1.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.4 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 3.4 GO:0051087 chaperone binding(GO:0051087)
0.0 0.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.6 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.7 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 1.6 GO:0097110 scaffold protein binding(GO:0097110)
0.0 1.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 6.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.6 ST ADRENERGIC Adrenergic Pathway
0.0 2.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 3.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 5.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 5.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 3.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 3.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 2.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 11.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 2.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 3.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 3.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.8 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 4.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 9.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.9 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 2.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 0.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 3.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 4.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+