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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PRDM14

Z-value: 0.21

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.4 PRDM14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg38_v1_chr8_-_70071226_700712580.091.9e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_-_21024092 9.96 ENST00000554398.5
NDRG2
NDRG family member 2
chr14_-_21023954 9.54 ENST00000554094.5
NDRG2
NDRG family member 2
chr17_-_19748285 7.39 ENST00000570414.1
ENST00000225740.11
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr11_-_62707581 7.39 ENST00000684475.1
ENST00000683296.1
ENST00000684067.1
ENST00000682223.1
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr17_-_19748341 7.35 ENST00000395555.7
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr11_-_62707413 7.15 ENST00000360796.10
ENST00000449636.6
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr17_-_19748355 6.78 ENST00000494157.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr11_+_62707668 6.46 ENST00000294117.6
GNG3
G protein subunit gamma 3
chr20_-_3173516 6.04 ENST00000360342.7
ENST00000645462.1
ENST00000337576.7
LZTS3
leucine zipper tumor suppressor family member 3
chr12_-_48957445 4.65 ENST00000541959.5
ENST00000447318.6
ENST00000256682.9
ARF3
ADP ribosylation factor 3
chr1_+_50105666 4.62 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr9_+_84668485 4.38 ENST00000359847.4
ENST00000395882.6
ENST00000376208.6
ENST00000376213.6
NTRK2
neurotrophic receptor tyrosine kinase 2
chr1_+_50106265 3.75 ENST00000357083.8
ELAVL4
ELAV like RNA binding protein 4
chr11_-_65856944 2.93 ENST00000524553.5
CFL1
cofilin 1
chr5_-_16936231 2.83 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
MYO10
myosin X
chr11_-_65857007 2.72 ENST00000527344.5
CFL1
cofilin 1
chr1_+_36155930 2.70 ENST00000316156.8
MAP7D1
MAP7 domain containing 1
chr16_+_53703963 2.64 ENST00000636218.1
ENST00000637001.1
ENST00000471389.6
ENST00000637969.1
ENST00000640179.1
FTO
FTO alpha-ketoglutarate dependent dioxygenase
chr1_+_65264694 2.63 ENST00000263441.11
ENST00000395325.7
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr22_+_22904850 2.55 ENST00000390324.2
IGLJ3
immunoglobulin lambda joining 3
chr22_+_22899481 2.50 ENST00000390322.2
IGLJ2
immunoglobulin lambda joining 2
chr12_-_52573816 2.45 ENST00000549343.5
ENST00000305620.3
KRT74
keratin 74
chr12_-_48957365 2.34 ENST00000398092.4
ENST00000539611.1
ENSG00000272822.2
ARF3
novel protein
ADP ribosylation factor 3
chr5_-_160685379 2.15 ENST00000642502.1
ATP10B
ATPase phospholipid transporting 10B (putative)
chr1_+_21570303 2.08 ENST00000374830.2
ALPL
alkaline phosphatase, biomineralization associated
chr7_-_124765753 1.99 ENST00000303921.3
GPR37
G protein-coupled receptor 37
chrX_+_51893533 1.79 ENST00000375722.5
ENST00000326587.12
ENST00000375695.2
MAGED1
MAGE family member D1
chr17_-_17582417 1.70 ENST00000395783.5
PEMT
phosphatidylethanolamine N-methyltransferase
chr11_+_65111845 1.60 ENST00000526809.5
ENST00000524986.5
ENST00000534371.5
ENST00000279263.14
ENST00000525385.5
ENST00000345348.9
ENST00000531321.5
ENST00000529414.5
ENST00000526085.5
ENST00000530750.5
TM7SF2
transmembrane 7 superfamily member 2
chr1_-_153094521 1.50 ENST00000368750.8
SPRR2E
small proline rich protein 2E
chr1_-_153113507 1.49 ENST00000468739.2
SPRR2F
small proline rich protein 2F
chr14_+_78170336 1.23 ENST00000634499.2
ENST00000335750.7
NRXN3
neurexin 3
chr2_-_227379297 1.22 ENST00000304568.4
TM4SF20
transmembrane 4 L six family member 20
chr19_+_38619082 1.13 ENST00000614624.4
ENST00000593149.5
ENST00000538434.5
ENST00000588934.5
ENST00000248342.9
ENST00000545173.6
ENST00000591409.5
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3 subunit K
chr5_-_24644968 1.06 ENST00000264463.8
CDH10
cadherin 10
chr7_-_141014939 1.05 ENST00000324787.10
ENST00000467334.1
MRPS33
mitochondrial ribosomal protein S33
chr8_-_101204697 0.95 ENST00000517844.5
ZNF706
zinc finger protein 706
chr10_+_12129637 0.94 ENST00000379051.5
ENST00000379033.7
ENST00000441368.5
ENST00000298428.14
ENST00000304267.12
ENST00000379020.8
ENST00000379017.7
SEC61A2
SEC61 translocon subunit alpha 2
chr5_-_135399863 0.87 ENST00000510038.1
ENST00000304332.8
MACROH2A1
macroH2A.1 histone
chr7_-_141014629 0.83 ENST00000393008.7
MRPS33
mitochondrial ribosomal protein S33
chr12_+_3491189 0.82 ENST00000382622.4
PRMT8
protein arginine methyltransferase 8
chr3_-_47475811 0.73 ENST00000265565.10
ENST00000428413.5
SCAP
SREBF chaperone
chr17_+_49575828 0.70 ENST00000328741.6
NXPH3
neurexophilin 3
chr19_-_48811012 0.68 ENST00000545387.6
ENST00000402551.5
ENST00000598162.5
ENST00000316273.11
ENST00000599246.5
BCAT2
branched chain amino acid transaminase 2
chr12_+_121210160 0.61 ENST00000542067.5
P2RX4
purinergic receptor P2X 4
chr3_+_156120572 0.59 ENST00000389636.9
ENST00000490337.6
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr17_-_48614628 0.58 ENST00000576562.1
HOXB8
homeobox B8
chr1_-_6261053 0.54 ENST00000377893.3
GPR153
G protein-coupled receptor 153
chr1_-_31373067 0.53 ENST00000373713.7
FABP3
fatty acid binding protein 3
chr11_-_46593948 0.52 ENST00000533727.5
ENST00000534300.5
ENST00000683756.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy and beclin 1 regulator 1
chr1_-_26890237 0.49 ENST00000431781.2
ENST00000374135.9
GPN2
GPN-loop GTPase 2
chr19_-_48810900 0.46 ENST00000597011.5
ENST00000601681.5
BCAT2
branched chain amino acid transaminase 2
chr1_-_40097216 0.43 ENST00000641083.1
ENST00000641471.1
ENST00000642050.2
ENST00000433473.8
ENST00000439754.6
ENST00000527311.7
ENST00000641319.1
ENST00000449045.7
PPT1
palmitoyl-protein thioesterase 1
chr20_-_50153637 0.37 ENST00000341698.2
ENST00000371652.9
ENST00000371650.9
PEDS1-UBE2V1
PEDS1
PEDS1-UBE2V1 readthrough
plasmanylethanolamine desaturase 1
chr10_+_88664439 0.36 ENST00000394375.7
ENST00000608620.5
ENST00000238983.9
ENST00000355843.2
LIPF
lipase F, gastric type
chr17_+_77453993 0.35 ENST00000592951.5
SEPTIN9
septin 9
chr4_-_102345469 0.34 ENST00000356736.5
ENST00000682932.1
SLC39A8
solute carrier family 39 member 8
chr4_+_4859658 0.30 ENST00000382723.5
MSX1
msh homeobox 1
chr6_-_46080332 0.27 ENST00000185206.12
CLIC5
chloride intracellular channel 5
chr9_+_129835442 0.25 ENST00000372429.8
ENST00000315480.9
ENST00000358355.5
USP20
ubiquitin specific peptidase 20
chr12_+_121210065 0.23 ENST00000359949.11
ENST00000337233.9
ENST00000538701.5
P2RX4
purinergic receptor P2X 4
chr14_+_22524325 0.18 ENST00000390517.1
TRAJ20
T cell receptor alpha joining 20
chr7_-_44541318 0.18 ENST00000381160.8
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr2_-_68871382 0.18 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chr16_-_67483541 0.17 ENST00000290953.3
AGRP
agouti related neuropeptide
chr12_-_76348404 0.12 ENST00000650064.2
BBS10
Bardet-Biedl syndrome 10
chr7_+_39950187 0.10 ENST00000181839.10
CDK13
cyclin dependent kinase 13
chr17_-_48615261 0.10 ENST00000239144.5
HOXB8
homeobox B8
chr7_-_44541262 0.07 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr5_+_32710630 0.01 ENST00000326958.5
NPR3
natriuretic peptide receptor 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 19.5 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.1 5.6 GO:2000814 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.9 2.6 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.7 14.5 GO:0034389 lipid particle organization(GO:0034389)
0.7 2.1 GO:0071529 cementum mineralization(GO:0071529)
0.6 4.4 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.3 1.1 GO:0006550 isoleucine catabolic process(GO:0006550)
0.2 2.0 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.2 2.6 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.2 1.7 GO:0050747 sphingomyelin biosynthetic process(GO:0006686) positive regulation of lipoprotein metabolic process(GO:0050747)
0.2 21.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.2 0.5 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.7 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 6.5 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.1 0.9 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.5 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.1 0.8 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 2.2 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 0.3 GO:0090427 embryonic nail plate morphogenesis(GO:0035880) activation of meiosis(GO:0090427)
0.1 0.4 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.1 7.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.8 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 3.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 2.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 2.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.7 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.0 1.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 1.6 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.5 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.3 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 7.5 GO:0006397 mRNA processing(GO:0006397)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 2.8 GO:0032433 filopodium tip(GO:0032433)
0.1 5.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 6.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 18.6 GO:0030426 growth cone(GO:0030426)
0.1 16.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.0 GO:0001533 cornified envelope(GO:0001533)
0.1 2.4 GO:0045095 keratin filament(GO:0045095)
0.1 5.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.5 GO:0016528 sarcoplasm(GO:0016528)
0.0 2.0 GO:0031526 brush border membrane(GO:0031526)
0.0 8.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 25.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 7.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 21.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.1 4.4 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.7 2.0 GO:0036505 prosaposin receptor activity(GO:0036505)
0.6 1.7 GO:0080101 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.5 1.6 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.5 2.4 GO:1990254 keratin filament binding(GO:1990254)
0.4 2.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.3 2.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.3 6.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.3 0.8 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 1.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 8.4 GO:0017091 AU-rich element binding(GO:0017091)
0.2 0.5 GO:0070538 oleic acid binding(GO:0070538)
0.1 1.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 2.6 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.3 GO:0031489 myosin V binding(GO:0031489)
0.1 2.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.8 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 5.6 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.4 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 2.1 GO:0043022 ribosome binding(GO:0043022)
0.0 0.4 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.6 GO:0070402 NADPH binding(GO:0070402)
0.0 6.7 GO:0003924 GTPase activity(GO:0003924)
0.0 2.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 19.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.8 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.0 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.3 6.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.2 5.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.8 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 2.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 4.4 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.9 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels