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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RAD21_SMC3

Z-value: 4.34

Motif logo

Transcription factors associated with RAD21_SMC3

Gene Symbol Gene ID Gene Info
ENSG00000164754.15 RAD21
ENSG00000108055.10 SMC3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMC3hg38_v1_chr10_+_110567666_110567765-0.471.4e-13Click!
RAD21hg38_v1_chr8_-_116874746_116874828-0.351.4e-07Click!

Activity profile of RAD21_SMC3 motif

Sorted Z-values of RAD21_SMC3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr8_+_24914942 23.37 ENST00000433454.3
neurofilament medium
chr9_+_128203397 20.05 ENST00000628346.2
ENST00000486160.3
ENST00000627061.2
ENST00000627543.2
ENST00000634267.2
dynamin 1
chr9_+_128203371 19.58 ENST00000475805.5
ENST00000372923.8
ENST00000341179.11
ENST00000393594.7
dynamin 1
chr16_-_23557331 18.95 ENST00000563232.1
ENST00000449606.7
glutamyl-tRNA synthetase 2, mitochondrial
chr1_+_10210562 18.62 ENST00000377093.9
ENST00000676179.1
kinesin family member 1B
chr16_-_19886133 16.68 ENST00000568214.1
ENST00000569479.5
G protein-coupled receptor class C group 5 member B
chr16_-_30021288 16.01 ENST00000574405.5
double C2 domain alpha
chr5_-_137499293 14.74 ENST00000510689.5
ENST00000394945.6
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
chr9_-_137028271 14.64 ENST00000265662.9
ENST00000371605.7
ATP binding cassette subfamily A member 2
chr16_-_2340703 14.35 ENST00000301732.10
ENST00000382381.7
ATP binding cassette subfamily A member 3
chr17_+_16690223 13.58 ENST00000340621.9
ENST00000399273.5
ENST00000456009.4
ENST00000360524.12
coiled-coil domain containing 144A
chr1_-_9943314 13.52 ENST00000377223.6
ENST00000377213.1
leucine zipper and CTNNBIP1 domain containing
chr1_+_151070740 13.34 ENST00000368918.8
GA binding protein transcription factor subunit beta 2
chr11_-_64723149 13.10 ENST00000377559.7
ENST00000265459.11
neurexin 2
chr7_+_156949704 13.01 ENST00000275820.4
nucleolar protein with MIF4G domain 1
chr12_+_13044371 12.41 ENST00000197268.13
family with sequence similarity 234 member B
chr1_-_34859717 11.89 ENST00000423898.1
ENST00000521580.3
ENST00000456842.1
small integral membrane protein 12
chr9_-_137028223 11.44 ENST00000341511.11
ATP binding cassette subfamily A member 2
chr19_+_4791710 11.21 ENST00000269856.5
fem-1 homolog A
chr19_-_48646155 10.88 ENST00000084798.9
carbonic anhydrase 11
chr10_-_78029487 10.75 ENST00000372371.8
RNA polymerase III subunit A
chr22_+_19718390 10.14 ENST00000383045.7
ENST00000438754.6
septin 5
chr1_+_9943428 10.06 ENST00000403197.5
ENST00000377205.6
nicotinamide nucleotide adenylyltransferase 1
chr5_+_157743703 9.95 ENST00000286307.6
LSM11, U7 small nuclear RNA associated
chr15_-_38564635 9.21 ENST00000450598.6
ENST00000559830.5
ENST00000558164.5
ENST00000539159.5
ENST00000310803.10
RAS guanyl releasing protein 1
chr21_+_39867387 9.14 ENST00000328619.10
Purkinje cell protein 4
chr19_-_57888780 8.91 ENST00000595048.5
ENST00000600634.5
ENST00000595295.1
ENST00000596604.5
ENST00000597342.5
ENST00000597807.1
zinc finger protein 814
chr5_+_35617838 8.73 ENST00000282469.10
ENST00000509059.5
ENST00000637569.1
ENST00000356031.8
ENST00000510777.5
sperm flagellar 2
chr19_+_8413270 8.65 ENST00000381035.8
ENST00000595142.5
ENST00000601724.5
ENST00000601283.5
ENST00000215555.7
ENST00000595213.1
membrane associated ring-CH-type finger 2
chr19_-_6481769 8.59 ENST00000381480.7
ENST00000543576.5
ENST00000590173.5
DENN domain containing 1C
chr7_-_100573865 8.46 ENST00000622764.3
Sin3A associated protein 25
chr5_-_118988504 8.37 ENST00000515439.7
ENST00000510708.6
DTW domain containing 2
chr2_+_148978361 8.36 ENST00000678720.1
ENST00000678856.1
ENST00000677080.1
kinesin family member 5C
chr8_-_100559702 8.31 ENST00000520311.5
ENST00000520552.5
ENST00000521345.1
ENST00000523000.5
ENST00000335659.7
ENST00000358990.3
ENST00000519597.5
ankyrin repeat domain 46
chr9_+_136665745 8.27 ENST00000371698.3
EGF like domain multiple 7
chr1_-_85259633 8.27 ENST00000344356.5
ENST00000471115.6
chromosome 1 open reading frame 52
chr4_+_70704713 8.19 ENST00000417478.6
RUN and FYVE domain containing 3
chr1_-_170074568 8.18 ENST00000367767.5
ENST00000361580.7
ENST00000538366.5
kinesin associated protein 3
chr2_+_112584586 7.85 ENST00000409719.1
coiled-coil-helix-coiled-coil-helix domain containing 5
chr3_+_5122276 7.78 ENST00000256496.8
ENST00000419534.2
ADP ribosylation factor like GTPase 8B
chr17_-_1187294 7.77 ENST00000544583.6
ABR activator of RhoGEF and GTPase
chr3_-_139044892 7.73 ENST00000413199.1
proline rich 23C
chr17_+_47733228 7.72 ENST00000177694.2
T-box transcription factor 21
chr13_+_87671354 7.48 ENST00000683689.1
SLIT and NTRK like family member 5
chr16_+_58500135 7.28 ENST00000563978.5
ENST00000569923.5
ENST00000356752.8
ENST00000563799.5
ENST00000562999.5
ENST00000570248.5
ENST00000562731.5
ENST00000568424.1
NDRG family member 4
chr2_+_102473219 7.22 ENST00000295269.5
solute carrier family 9 member A4
chr12_-_101830799 7.21 ENST00000549940.5
ENST00000392919.4
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr10_-_15371225 7.21 ENST00000378116.9
family with sequence similarity 171 member A1
chr2_+_165239432 7.11 ENST00000636071.2
ENST00000636985.2
sodium voltage-gated channel alpha subunit 2
chr5_+_55160161 7.01 ENST00000296734.6
ENST00000515370.1
ENST00000503787.6
glutathione peroxidase 8 (putative)
chr16_+_1706163 6.73 ENST00000250894.8
ENST00000673691.1
ENST00000356010.9
ENST00000610761.2
mitogen-activated protein kinase 8 interacting protein 3
chr16_+_30748241 6.71 ENST00000565924.5
ENST00000424889.7
phosphorylase kinase catalytic subunit gamma 2
chrX_-_107777038 6.69 ENST00000480691.2
ENST00000506081.5
ENST00000514426.1
TSC22 domain family member 3
chr4_+_127965429 6.67 ENST00000513371.1
ENST00000611882.1
abhydrolase domain containing 18
chr8_-_30812867 6.64 ENST00000518243.5
protein phosphatase 2 catalytic subunit beta
chr1_-_212035513 6.64 ENST00000366992.7
ENST00000366993.7
ENST00000440600.6
ENST00000366994.8
integrator complex subunit 7
chr2_-_165203870 6.54 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
sodium voltage-gated channel alpha subunit 3
chr3_-_184017863 6.52 ENST00000427120.6
ENST00000334444.11
ENST00000392579.6
ENST00000382494.6
ENST00000265586.10
ENST00000446941.2
ATP binding cassette subfamily C member 5
chr16_-_49281819 6.35 ENST00000219197.11
cerebellin 1 precursor
chr11_+_67266437 6.34 ENST00000308595.10
ENST00000526285.1
G protein-coupled receptor kinase 2
chr11_+_46347526 6.21 ENST00000456247.6
ENST00000421244.6
ENST00000318201.12
diacylglycerol kinase zeta
chr2_-_165204042 6.21 ENST00000283254.12
ENST00000453007.1
sodium voltage-gated channel alpha subunit 3
chr19_-_48835823 6.20 ENST00000595764.1
hydroxysteroid 17-beta dehydrogenase 14
chr9_-_131740056 6.14 ENST00000372195.5
ENST00000683357.1
Rap guanine nucleotide exchange factor 1
chr17_+_45135640 6.03 ENST00000586346.5
ENST00000321854.13
ENST00000398322.7
ENST00000592162.5
ENST00000376955.8
acyl-CoA binding domain containing 4
chr8_-_144444406 6.03 ENST00000409379.8
tonsoku like, DNA repair protein
chr11_-_117232033 6.00 ENST00000524507.6
ENST00000320934.8
ENST00000532301.5
ENST00000676339.1
ENST00000540028.5
proprotein convertase subtilisin/kexin type 7
chr19_+_36916298 5.86 ENST00000427117.5
ENST00000333987.12
ENST00000587130.5
ENST00000415168.5
ENST00000444991.5
zinc finger protein 568
chr7_-_91880672 5.83 ENST00000456229.1
ENST00000442961.1
ENST00000406735.6
ENST00000419292.1
ENST00000351870.8
mitochondrial transcription termination factor 1
chr17_-_39152571 5.80 ENST00000415163.5
ENST00000441877.5
ENST00000444911.6
plexin domain containing 1
chr7_-_102464842 5.78 ENST00000292566.4
alkB homolog 4, lysine demethylase
chr20_+_31514410 5.74 ENST00000335574.10
ENST00000340852.9
ENST00000398174.9
ENST00000466766.2
ENST00000498035.5
ENST00000344042.5
histocompatibility minor 13
chr2_-_231530427 5.71 ENST00000305141.5
neuromedin U receptor 1
chr2_-_165953750 5.69 ENST00000243344.8
ENST00000679799.1
ENST00000679840.1
ENST00000681606.1
ENST00000680448.1
tetratricopeptide repeat domain 21B
chr2_+_165239388 5.65 ENST00000424833.5
ENST00000375437.7
ENST00000631182.3
sodium voltage-gated channel alpha subunit 2
chr4_+_7043315 5.62 ENST00000310074.8
ENST00000512388.1
transcriptional adaptor 2B
chr19_+_47349298 5.59 ENST00000328771.9
DExH-box helicase 34
chr17_+_45894515 5.55 ENST00000680674.1
ENST00000535772.6
ENST00000351559.10
ENST00000262410.10
ENST00000344290.10
microtubule associated protein tau
chr19_-_19643597 5.55 ENST00000587205.1
ENST00000203556.9
GEM interacting protein
chr17_-_7614824 5.55 ENST00000571597.1
ENST00000250113.12
FMR1 autosomal homolog 2
chr22_+_22697789 5.54 ENST00000390306.2
immunoglobulin lambda variable 2-23
chr16_+_30748378 5.39 ENST00000563588.6
ENST00000328273.11
phosphorylase kinase catalytic subunit gamma 2
chr4_+_127965394 5.27 ENST00000645843.2
ENST00000388795.9
abhydrolase domain containing 18
chrX_+_153764178 5.27 ENST00000538966.5
plexin B3
chr19_-_19643547 5.25 ENST00000587238.5
GEM interacting protein
chr19_+_12838437 5.22 ENST00000251472.9
microtubule associated serine/threonine kinase 1
chr17_+_45894644 5.22 ENST00000680542.1
ENST00000334239.12
ENST00000446361.7
microtubule associated protein tau
chr22_-_21952827 5.21 ENST00000397495.8
ENST00000263212.10
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr2_+_11133119 5.20 ENST00000381585.8
ENST00000405022.3
chromosome 2 open reading frame 50
chr1_+_27392612 5.14 ENST00000374024.4
G protein-coupled receptor 3
chr9_-_133149334 5.14 ENST00000393160.7
ral guanine nucleotide dissociation stimulator
chr5_-_141618914 5.04 ENST00000518047.5
diaphanous related formin 1
chr6_-_41779859 5.00 ENST00000373018.7
fibroblast growth factor receptor substrate 3
chr8_+_28622729 4.98 ENST00000523149.5
exostosin like glycosyltransferase 3
chr1_+_205256189 4.95 ENST00000329800.7
transmembrane and coiled-coil domain family 2
chr1_+_17755307 4.90 ENST00000375406.2
actin like 8
chr15_+_70892809 4.86 ENST00000260382.10
ENST00000560755.5
leucine rich repeat containing 49
chr9_-_137423153 4.79 ENST00000479452.5
ENST00000340951.9
ENST00000465160.2
exonuclease 3'-5' domain containing 3
chr6_+_127266832 4.78 ENST00000356799.6
ENST00000368314.6
ring finger protein 146
chr9_-_91950201 4.75 ENST00000375708.4
receptor tyrosine kinase like orphan receptor 2
chr19_-_57889004 4.73 ENST00000597832.5
ENST00000435989.7
ENST00000614383.1
zinc finger protein 814
chr1_+_50048014 4.71 ENST00000448907.7
ELAV like RNA binding protein 4
chr14_+_21978440 4.70 ENST00000390443.3
T cell receptor alpha variable 8-6
chr9_+_84668485 4.66 ENST00000359847.4
ENST00000395882.6
ENST00000376208.6
ENST00000376213.6
neurotrophic receptor tyrosine kinase 2
chr10_+_124461800 4.55 ENST00000368842.10
ENST00000392757.8
ENST00000368839.1
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr8_-_144787275 4.55 ENST00000343459.8
ENST00000429371.7
ENST00000534445.1
zinc finger protein 34
chr22_-_21938557 4.51 ENST00000424647.1
ENST00000407142.5
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr2_-_166128004 4.36 ENST00000303395.9
ENST00000674923.1
ENST00000637988.1
ENST00000635776.1
sodium voltage-gated channel alpha subunit 1
chr17_-_27893339 4.32 ENST00000460380.6
ENST00000379102.8
ENST00000508862.5
ENST00000582441.1
LYR motif containing 9
novel protein
chr6_+_127266875 4.27 ENST00000610162.5
ENST00000608991.5
ENST00000610153.1
ring finger protein 146
chr11_-_130916437 4.24 ENST00000533214.1
ENST00000528555.5
ENST00000530356.5
ENST00000265909.9
sorting nexin 19
chr14_-_69574845 4.23 ENST00000599174.3
coiled-coil domain containing 177
chr12_+_120640552 4.21 ENST00000316803.7
calcium binding protein 1
chr19_-_45815228 4.21 ENST00000597055.1
radial spoke head 6 homolog A
chr5_+_140786136 4.12 ENST00000378133.4
ENST00000504120.4
protocadherin alpha 1
chr12_-_101830671 4.11 ENST00000549165.1
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr15_+_65611336 4.09 ENST00000537259.5
solute carrier family 24 member 1
chr14_+_24161257 4.08 ENST00000396864.8
ENST00000557894.5
ENST00000559284.5
ENST00000560275.5
interferon regulatory factor 9
chrX_+_153764233 4.07 ENST00000361971.10
plexin B3
chr11_+_2400488 4.03 ENST00000380996.9
ENST00000380992.5
ENST00000333256.11
ENST00000437110.5
ENST00000435795.5
tumor suppressing subtransferable candidate 4
chr1_+_220690354 4.03 ENST00000294889.6
chromosome 1 open reading frame 115
chr2_-_174487005 4.02 ENST00000392552.7
ENST00000295500.8
ENST00000614352.4
ENST00000392551.6
G protein-coupled receptor 155
chr12_-_101830926 4.00 ENST00000299314.12
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr11_+_61752603 3.99 ENST00000278836.10
myelin regulatory factor
chr16_-_70680025 3.97 ENST00000576338.1
MTSS I-BAR domain containing 2
chr17_-_9959455 3.97 ENST00000580865.5
ENST00000583882.5
growth arrest specific 7
chr15_+_68578970 3.96 ENST00000261861.10
coronin 2B
chr20_+_3820515 3.91 ENST00000246041.6
ENST00000379573.6
ENST00000379567.6
ENST00000455742.5
ENST00000615891.2
adaptor related protein complex 5 subunit sigma 1
chr16_+_22206255 3.91 ENST00000263026.10
eukaryotic elongation factor 2 kinase
chr14_-_93115812 3.88 ENST00000553452.5
inositol-tetrakisphosphate 1-kinase
chr1_-_211133945 3.85 ENST00000640044.1
ENST00000640566.1
potassium voltage-gated channel subfamily H member 1
chr9_+_89318811 3.83 ENST00000534113.6
SECIS binding protein 2
chr2_-_74482914 3.83 ENST00000290418.4
ENST00000393965.8
coiled-coil domain containing 142
chr16_+_71358713 3.67 ENST00000349553.9
ENST00000302628.9
ENST00000562305.5
calbindin 2
chr12_-_56189459 3.64 ENST00000550164.6
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
chr16_-_740934 3.61 ENST00000540986.5
cytosolic iron-sulfur assembly component 3
chr1_+_109984756 3.58 ENST00000393614.8
ENST00000369799.10
adenosylhomocysteinase like 1
chr12_-_113135710 3.57 ENST00000446861.7
RAS protein activator like 1
chr2_+_230864921 3.55 ENST00000326427.11
ENST00000335005.10
ENST00000326407.10
integral membrane protein 2C
chr16_+_83968244 3.55 ENST00000305202.9
N-terminal EF-hand calcium binding protein 2
chr12_-_123533705 3.53 ENST00000636882.1
ENST00000376874.9
Rab interacting lysosomal protein like 1
chr11_+_46347425 3.53 ENST00000527911.5
diacylglycerol kinase zeta
chr9_+_131009141 3.47 ENST00000361069.9
laminin subunit gamma 3
chr9_+_89318492 3.44 ENST00000375807.8
ENST00000339901.8
SECIS binding protein 2
chr11_+_66258467 3.40 ENST00000394066.6
kinesin light chain 2
chr2_+_6917404 3.38 ENST00000320892.11
ring finger protein 144A
chr16_-_740980 3.36 ENST00000251588.7
cytosolic iron-sulfur assembly component 3
chr11_+_925809 3.36 ENST00000332231.9
adaptor related protein complex 2 subunit alpha 2
chr1_+_228165794 3.35 ENST00000366711.4
iron-sulfur cluster assembly factor IBA57
chr17_-_8079903 3.33 ENST00000649809.1
arachidonate 12-lipoxygenase, 12R type
chr10_+_97572771 3.32 ENST00000370655.6
ENST00000455090.1
ankyrin repeat domain 2
chr7_-_38349972 3.31 ENST00000390344.2
T cell receptor gamma variable 5
chr9_+_19049385 3.31 ENST00000380527.3
Ras related GTP binding A
chr6_+_31137646 3.30 ENST00000547221.1
psoriasis susceptibility 1 candidate 1
chr11_+_60924452 3.28 ENST00000453848.7
ENST00000544065.5
ENST00000005286.8
transmembrane protein 132A
chr11_-_36510232 3.27 ENST00000348124.5
ENST00000526995.6
TNF receptor associated factor 6
chr16_+_15643267 3.25 ENST00000396355.5
nudE neurodevelopment protein 1
chr11_+_73289403 3.24 ENST00000535931.2
ENST00000544437.6
pyrimidinergic receptor P2Y6
chrX_-_30308333 3.23 ENST00000378963.1
nuclear receptor subfamily 0 group B member 1
chr10_+_110225955 3.22 ENST00000239007.11
MAX interactor 1, dimerization protein
chr3_+_50273119 3.19 ENST00000456560.6
ENST00000418576.3
semaphorin 3B
chr5_-_179907821 3.19 ENST00000630103.1
ENST00000356834.7
ENST00000355235.8
TBC1 domain family member 9B
chr15_-_64046322 3.17 ENST00000457488.5
ENST00000612884.4
death associated protein kinase 2
chr1_+_1435523 3.14 ENST00000338660.5
ENST00000476993.2
ENST00000471398.1
von Willebrand factor A domain containing 1
chr17_-_8965674 3.14 ENST00000447110.6
ENST00000611902.4
ENST00000616147.4
ENST00000623421.3
phosphoinositide-3-kinase regulatory subunit 5
chr22_+_23070496 3.14 ENST00000615612.2
G protein subunit alpha z
chr11_-_118565992 3.12 ENST00000264020.6
intraflagellar transport 46
chr9_-_137046160 3.09 ENST00000371601.5
neural proliferation, differentiation and control 1
chr1_+_168179030 3.08 ENST00000367830.3
TOR signaling pathway regulator
chr10_-_101843920 3.06 ENST00000358038.7
potassium voltage-gated channel interacting protein 2
chr20_+_58852710 3.04 ENST00000676826.2
ENST00000371100.9
GNAS complex locus
chr9_+_97412062 2.98 ENST00000355295.5
tudor domain containing 7
chr7_-_122886706 2.97 ENST00000313070.11
ENST00000334010.11
ENST00000615869.4
calcium dependent secretion activator 2
chr1_+_47438036 2.97 ENST00000334793.6
forkhead box D2
chr19_-_45815303 2.96 ENST00000221538.8
radial spoke head 6 homolog A
chr1_+_10430720 2.93 ENST00000602296.6
CENPS-CORT readthrough
chr11_+_119206298 2.93 ENST00000634586.1
ENST00000634840.1
ENST00000264033.6
ENST00000637974.1
Cbl proto-oncogene
chr17_-_8383164 2.90 ENST00000584164.6
ENST00000582556.5
ENST00000648839.1
ENST00000578812.5
ENST00000583011.6
ribosomal protein L26
chr3_+_113838772 2.90 ENST00000358160.9
GRAM domain containing 1C
chr15_-_34210073 2.85 ENST00000559515.1
ENST00000560108.5
ENST00000256544.8
ENST00000559462.1
katanin regulatory subunit B1 like 1
chr6_-_136550819 2.85 ENST00000616617.4
ENST00000618822.4
microtubule associated protein 7
chr8_-_144326842 2.83 ENST00000528718.6
diacylglycerol O-acyltransferase 1
chr11_-_72793592 2.83 ENST00000536377.5
ENST00000359373.9
StAR related lipid transfer domain containing 10
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr14_-_91060578 2.80 ENST00000418736.6
ENST00000614987.5
ribosomal protein S6 kinase A5
chr4_+_127965267 2.79 ENST00000398965.5
abhydrolase domain containing 18
chr11_-_64744102 2.77 ENST00000431822.5
ENST00000394432.8
ENST00000377486.7
RAS guanyl releasing protein 2
chr17_+_65137344 2.75 ENST00000262406.10
regulator of G protein signaling 9
chr7_-_122886439 2.74 ENST00000412584.6
ENST00000449022.7
calcium dependent secretion activator 2
chr7_-_5529949 2.74 ENST00000642480.2
ENST00000417101.2
actin beta
chr4_+_127965361 2.73 ENST00000444616.5
abhydrolase domain containing 18
chrX_+_11758159 2.73 ENST00000361672.6
ENST00000337339.7
ENST00000647869.1
ENST00000312196.10
ENST00000647857.1
ENST00000649130.1
MSL complex subunit 3
chr5_+_140841183 2.70 ENST00000378123.4
ENST00000531613.2
protocadherin alpha 8
chr15_-_78811415 2.69 ENST00000388820.5
ADAM metallopeptidase with thrombospondin type 1 motif 7
chr12_-_113136224 2.68 ENST00000546530.5
ENST00000261729.9
RAS protein activator like 1
chr17_+_49575828 2.67 ENST00000328741.6
neurexophilin 3
chr12_-_95073490 2.66 ENST00000330677.7
nuclear receptor subfamily 2 group C member 1
chr20_-_44311142 2.65 ENST00000396825.4
fat storage inducing transmembrane protein 2
chr10_-_48524236 2.62 ENST00000374170.5
Rho GTPase activating protein 22
chr8_+_42271289 2.62 ENST00000520810.6
ENST00000520835.7
inhibitor of nuclear factor kappa B kinase subunit beta
chr19_+_10416773 2.60 ENST00000592685.5
phosphodiesterase 4A

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.2 39.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
5.8 23.4 GO:0033693 neurofilament bundle assembly(GO:0033693)
5.1 15.3 GO:0016256 N-glycan processing to lysosome(GO:0016256)
4.3 26.1 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
2.7 8.2 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
2.7 19.0 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
2.5 10.1 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
2.2 10.8 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
2.0 12.1 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
1.9 7.8 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
1.9 5.8 GO:0036090 cleavage furrow ingression(GO:0036090)
1.7 10.0 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.5 9.2 GO:0032252 secretory granule localization(GO:0032252)
1.3 3.9 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
1.3 3.9 GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557)
1.2 13.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
1.2 4.8 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
1.2 4.7 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
1.1 3.3 GO:0072573 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
1.1 4.2 GO:1990502 dense core granule maturation(GO:1990502)
1.1 6.3 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) positive regulation of long term synaptic depression(GO:1900454)
1.0 12.8 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
1.0 3.9 GO:1990637 response to prolactin(GO:1990637)
0.9 9.3 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.9 6.4 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.9 2.7 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.9 3.6 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
0.9 16.7 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.9 2.6 GO:1903028 positive regulation of opsonization(GO:1903028)
0.8 6.7 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.8 2.5 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.8 5.7 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.8 7.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.8 2.3 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.8 3.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.8 6.1 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.7 9.7 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.7 2.8 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.7 14.8 GO:0021756 striatum development(GO:0021756)
0.7 2.7 GO:0031627 telomeric loop formation(GO:0031627)
0.7 2.6 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.6 18.6 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.6 2.5 GO:0050893 sensory processing(GO:0050893)
0.6 4.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.6 7.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.6 10.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.6 5.8 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.6 14.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.6 2.9 GO:1990164 histone H3-S28 phosphorylation(GO:0043988) histone H2A phosphorylation(GO:1990164)
0.6 4.6 GO:0034454 microtubule anchoring at centrosome(GO:0034454) positive regulation of microtubule nucleation(GO:0090063)
0.6 2.9 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.6 2.3 GO:0016095 polyprenol catabolic process(GO:0016095) dolichol metabolic process(GO:0019348)
0.6 5.7 GO:1990504 dense core granule exocytosis(GO:1990504)
0.6 1.7 GO:0071529 cementum mineralization(GO:0071529)
0.6 3.9 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.6 1.7 GO:2000722 mineralocorticoid receptor signaling pathway(GO:0031959) regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722)
0.6 6.6 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.5 7.7 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.5 3.3 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.5 3.2 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.5 3.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.5 3.9 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.5 2.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.5 7.7 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.5 13.0 GO:0048820 hair follicle maturation(GO:0048820)
0.5 1.4 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.5 1.8 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.4 5.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 3.3 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.4 2.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.4 1.2 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.4 1.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 6.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.4 4.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.4 1.2 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.4 6.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.4 5.7 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.4 1.9 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.4 2.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.4 16.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.4 7.1 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.3 1.0 GO:0002588 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.3 2.0 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.3 3.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 2.9 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.3 3.6 GO:1904424 regulation of GTP binding(GO:1904424)
0.3 3.6 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.3 3.5 GO:0032594 protein transport within lipid bilayer(GO:0032594)
0.3 1.6 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.3 5.3 GO:0060973 cell migration involved in heart development(GO:0060973)
0.3 6.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.3 4.4 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.3 0.9 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.3 3.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 3.3 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.3 2.7 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.3 3.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.3 2.3 GO:0045023 G0 to G1 transition(GO:0045023)
0.3 2.8 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.3 0.8 GO:2000832 negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.3 4.1 GO:0009642 response to light intensity(GO:0009642)
0.3 1.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 2.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 3.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.3 0.8 GO:0046967 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) cytosol to ER transport(GO:0046967)
0.3 1.6 GO:0042997 negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.3 9.2 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.3 3.3 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.2 12.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 0.7 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.2 3.0 GO:0071318 cellular response to ATP(GO:0071318)
0.2 1.3 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.2 0.9 GO:0006408 snRNA export from nucleus(GO:0006408)
0.2 2.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 1.1 GO:2000143 negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.2 2.7 GO:0035878 nail development(GO:0035878)
0.2 8.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 1.6 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.2 2.0 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 4.5 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.2 1.2 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.2 3.0 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.2 3.1 GO:0048266 behavioral response to pain(GO:0048266)
0.2 5.1 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.2 0.5 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.2 5.7 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.2 5.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.2 14.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.2 5.9 GO:0008045 motor neuron axon guidance(GO:0008045)
0.2 9.2 GO:0019228 neuronal action potential(GO:0019228)
0.2 2.6 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 5.4 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.2 2.3 GO:0006020 inositol metabolic process(GO:0006020)
0.2 0.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 4.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 7.3 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 7.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.6 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.1 2.4 GO:0015671 oxygen transport(GO:0015671)
0.1 7.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 0.4 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 6.7 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.1 2.6 GO:0030575 nuclear body organization(GO:0030575)
0.1 9.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.8 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 5.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 3.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 6.0 GO:0016486 peptide hormone processing(GO:0016486)
0.1 2.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 12.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.8 GO:0014850 response to muscle activity(GO:0014850)
0.1 1.2 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.1 3.5 GO:0014002 astrocyte development(GO:0014002)
0.1 3.2 GO:0050919 negative chemotaxis(GO:0050919)
0.1 1.9 GO:0022038 corpus callosum development(GO:0022038)
0.1 1.3 GO:0042346 positive regulation of NF-kappaB import into nucleus(GO:0042346)
0.1 4.9 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 11.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 2.3 GO:0048745 smooth muscle tissue development(GO:0048745)
0.1 8.0 GO:0032418 lysosome localization(GO:0032418)
0.1 0.4 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 4.2 GO:1904590 negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein import(GO:1904590)
0.1 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 1.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 5.8 GO:0021510 spinal cord development(GO:0021510)
0.1 2.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 4.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 1.7 GO:0006853 carnitine shuttle(GO:0006853)
0.1 3.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 6.0 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 0.3 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.1 0.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 1.3 GO:0014029 neural crest formation(GO:0014029)
0.1 12.3 GO:0051384 response to glucocorticoid(GO:0051384)
0.1 0.5 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 2.1 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.1 1.1 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 2.2 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 0.7 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.1 1.0 GO:0034389 lipid particle organization(GO:0034389)
0.1 1.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.8 GO:0015732 prostaglandin transport(GO:0015732)
0.1 0.2 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 2.5 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 3.2 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 3.7 GO:0006970 response to osmotic stress(GO:0006970)
0.1 3.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.0 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 4.2 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.9 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 2.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.8 GO:0010107 potassium ion import(GO:0010107)
0.0 1.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 4.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.7 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 3.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.7 GO:0042737 drug catabolic process(GO:0042737)
0.0 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 5.4 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 1.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0 0.7 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 2.2 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 1.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 1.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.8 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 2.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.4 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.3 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.2 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.6 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.0 0.3 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 2.5 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.6 GO:0016266 O-glycan processing(GO:0016266)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0016939 kinesin II complex(GO:0016939)
2.6 26.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
2.3 34.1 GO:0097418 neurofibrillary tangle(GO:0097418)
1.2 30.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.2 12.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
1.1 5.7 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
1.1 3.4 GO:0016938 kinesin I complex(GO:0016938)
1.1 9.5 GO:0097208 alveolar lamellar body(GO:0097208)
1.0 3.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.9 10.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.8 46.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.8 5.7 GO:0030991 intraciliary transport particle A(GO:0030991)
0.7 2.0 GO:0000125 PCAF complex(GO:0000125)
0.6 8.4 GO:0035253 ciliary rootlet(GO:0035253)
0.6 2.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.6 6.6 GO:0032039 integrator complex(GO:0032039)
0.6 2.3 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.6 3.3 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.5 5.8 GO:0070938 contractile ring(GO:0070938)
0.5 6.0 GO:0042555 MCM complex(GO:0042555)
0.5 1.8 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.4 3.6 GO:0000322 storage vacuole(GO:0000322)
0.4 8.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.4 14.7 GO:0033268 node of Ranvier(GO:0033268)
0.4 20.3 GO:0005871 kinesin complex(GO:0005871)
0.4 5.6 GO:0030914 STAGA complex(GO:0030914)
0.3 12.3 GO:0042629 mast cell granule(GO:0042629)
0.3 2.7 GO:0072487 MSL complex(GO:0072487)
0.3 4.6 GO:0005869 dynactin complex(GO:0005869)
0.3 3.0 GO:0033391 chromatoid body(GO:0033391)
0.3 5.9 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 0.6 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3 3.1 GO:0005614 interstitial matrix(GO:0005614)
0.3 0.9 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.3 6.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 8.0 GO:0071437 invadopodium(GO:0071437)
0.3 2.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.3 3.2 GO:0042788 polysomal ribosome(GO:0042788)
0.3 1.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 1.5 GO:0005879 axonemal microtubule(GO:0005879)
0.3 4.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.2 5.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 4.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 1.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 2.7 GO:0097433 dense body(GO:0097433)
0.2 1.7 GO:0044327 dendritic spine head(GO:0044327)
0.2 5.8 GO:0051233 spindle midzone(GO:0051233)
0.2 1.0 GO:0072558 NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
0.2 0.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 7.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 1.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 5.6 GO:0016514 SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)
0.2 6.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 2.4 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.8 GO:0042825 TAP complex(GO:0042825)
0.1 2.3 GO:0000145 exocyst(GO:0000145)
0.1 5.7 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 2.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.3 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 15.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.3 GO:0001741 XY body(GO:0001741)
0.1 6.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.5 GO:0005921 gap junction(GO:0005921)
0.1 15.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 3.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 32.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 7.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 6.6 GO:0016459 myosin complex(GO:0016459)
0.1 1.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 1.1 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 5.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 6.7 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.1 GO:0097440 apical dendrite(GO:0097440)
0.1 4.5 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 6.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 2.5 GO:0005581 collagen trimer(GO:0005581)
0.1 3.5 GO:0005604 basement membrane(GO:0005604)
0.1 3.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 3.2 GO:0005776 autophagosome(GO:0005776)
0.0 4.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 5.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 12.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.2 GO:0031674 I band(GO:0031674)
0.0 3.6 GO:0035579 specific granule membrane(GO:0035579)
0.0 5.7 GO:0005769 early endosome(GO:0005769)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.0 5.1 GO:0098793 presynapse(GO:0098793)
0.0 7.0 GO:0043235 receptor complex(GO:0043235)
0.0 5.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 5.4 GO:0019867 outer membrane(GO:0019867)
0.0 1.6 GO:0036064 ciliary basal body(GO:0036064)
0.0 4.8 GO:0005929 cilium(GO:0005929)
0.0 3.8 GO:0005938 cell cortex(GO:0005938)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0001726 ruffle(GO:0001726)
0.0 1.0 GO:0030027 lamellipodium(GO:0030027)
0.0 0.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 36.7 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 15.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
3.7 11.2 GO:0031862 prostanoid receptor binding(GO:0031862)
2.7 10.8 GO:0099609 microtubule lateral binding(GO:0099609)
2.5 10.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
2.1 6.3 GO:0031755 endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755)
2.0 6.1 GO:0052825 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol tetrakisphosphate kinase activity(GO:0051765) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
1.8 5.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.7 5.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
1.5 4.6 GO:0008969 phosphohistidine phosphatase activity(GO:0008969)
1.3 9.3 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
1.2 12.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
1.2 3.6 GO:0031687 A2A adenosine receptor binding(GO:0031687)
1.2 4.7 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
1.1 3.3 GO:0001601 peptide YY receptor activity(GO:0001601)
1.1 9.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
1.0 7.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
1.0 5.0 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.9 6.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.9 2.7 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.9 6.2 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.9 2.6 GO:0008384 IkappaB kinase activity(GO:0008384)
0.8 19.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.8 5.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.8 2.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.8 2.4 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.8 26.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.8 2.3 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.8 7.7 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.7 6.7 GO:0043426 MRF binding(GO:0043426)
0.7 4.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.7 4.1 GO:0022821 calcium, potassium:sodium antiporter activity(GO:0008273) potassium ion antiporter activity(GO:0022821)
0.7 4.8 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.7 14.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.7 3.3 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.7 2.0 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.6 9.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.6 8.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.6 27.5 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.6 10.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.6 3.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.6 12.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.6 2.9 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.6 3.9 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.6 6.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.6 2.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.5 3.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.5 3.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 3.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 3.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.5 13.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 2.3 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.4 6.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.4 7.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 7.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 42.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.4 4.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 3.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 1.0 GO:0032090 Pyrin domain binding(GO:0032090)
0.3 3.4 GO:0003777 microtubule motor activity(GO:0003777)
0.3 2.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3 6.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.3 2.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.3 2.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.3 1.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.3 6.0 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.3 2.2 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 0.8 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.3 0.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 16.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 1.0 GO:0035473 lipase binding(GO:0035473)
0.2 3.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 3.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 7.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 3.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 1.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 8.2 GO:0019894 kinesin binding(GO:0019894)
0.2 3.3 GO:0015643 toxic substance binding(GO:0015643)
0.2 10.0 GO:0017069 snRNA binding(GO:0017069)
0.2 2.6 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2 65.7 GO:0008017 microtubule binding(GO:0008017)
0.2 3.0 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 1.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 0.6 GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity(GO:0004577)
0.2 1.7 GO:1990239 steroid hormone binding(GO:1990239)
0.2 4.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 3.7 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.0 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.2 3.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 5.1 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.2 0.5 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.2 3.9 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.2 6.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 2.8 GO:0031701 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.2 2.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 2.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.1 1.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 4.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 4.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 2.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.9 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.6 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 1.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 3.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 2.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 3.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 4.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 5.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 4.1 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 5.6 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 3.0 GO:0030332 cyclin binding(GO:0030332)
0.1 0.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.7 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 1.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 4.6 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 8.0 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 2.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 2.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.6 GO:0030552 cAMP binding(GO:0030552)
0.1 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.8 GO:0030506 ankyrin binding(GO:0030506)
0.1 11.5 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 6.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 0.7 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 2.0 GO:0043236 laminin binding(GO:0043236)
0.1 0.9 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 3.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 3.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.7 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 13.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 4.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 7.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.8 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.4 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 10.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 24.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 3.4 GO:0051015 actin filament binding(GO:0051015)
0.0 0.9 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.2 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 40.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.7 14.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 5.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.4 17.9 PID RAS PATHWAY Regulation of Ras family activation
0.3 14.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 17.8 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.3 8.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 5.3 PID IL23 PATHWAY IL23-mediated signaling events
0.2 2.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.2 3.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 16.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 4.4 PID IL27 PATHWAY IL27-mediated signaling events
0.1 5.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 3.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 4.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 1.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 6.6 PID AURORA A PATHWAY Aurora A signaling
0.1 2.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 12.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 20.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 9.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 4.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 4.3 PID ENDOTHELIN PATHWAY Endothelins
0.1 5.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 4.5 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 3.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 21.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 1.6 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 2.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.6 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 2.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 3.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.9 PID E2F PATHWAY E2F transcription factor network
0.0 1.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 39.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
1.8 40.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.7 5.9 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.5 7.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.4 12.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.4 6.6 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.4 5.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 10.0 REACTOME KINESINS Genes involved in Kinesins
0.4 15.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 6.1 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.3 10.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 6.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.3 6.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.3 12.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 1.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.3 4.9 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 6.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 2.9 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 3.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 5.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 2.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 3.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.2 3.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 4.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 2.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 3.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 10.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 10.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 4.9 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 2.0 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.5 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 6.8 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.7 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.6 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 15.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 2.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.8 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 8.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 3.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.4 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.1 2.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 0.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.9 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 12.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 0.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 4.7 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 4.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 2.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases