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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RARA
Z-value: 0.53
Motif logo
Transcription factors associated with RARA
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RARA
|
ENSG00000131759.18 | RARA |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARA | hg38_v1_chr17_+_40318237_40318299 | -0.23 | 4.8e-04 | Click! |
Activity profile of RARA motif
Sorted Z-values of RARA motif
Network of associatons between targets according to the STRING database.
First level regulatory network of RARA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 4.1 | GO:1902957 | negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957) |
| 3.0 | 9.1 | GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 1.9 | 7.8 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 1.6 | 11.3 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 1.3 | 3.8 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.2 | 7.1 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 1.1 | 4.4 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 1.1 | 4.3 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.9 | 2.8 | GO:0003213 | cardiac right atrium morphogenesis(GO:0003213) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) regulation of cell proliferation in midbrain(GO:1904933) |
| 0.9 | 4.6 | GO:0045906 | negative regulation of vasoconstriction(GO:0045906) |
| 0.9 | 2.7 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.9 | 2.6 | GO:1903778 | positive regulation of histamine secretion by mast cell(GO:1903595) protein localization to vacuolar membrane(GO:1903778) |
| 0.8 | 2.4 | GO:0009447 | putrescine catabolic process(GO:0009447) |
| 0.7 | 3.0 | GO:0018032 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 0.6 | 1.9 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.6 | 3.1 | GO:0044858 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 0.6 | 2.9 | GO:0019087 | transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295) |
| 0.5 | 4.4 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.5 | 6.9 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.5 | 2.1 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.5 | 2.0 | GO:0006235 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
| 0.5 | 2.3 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.5 | 1.4 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.4 | 3.5 | GO:0030997 | regulation of centriole-centriole cohesion(GO:0030997) |
| 0.4 | 5.5 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.4 | 7.8 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.4 | 1.1 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) positive regulation of response to alcohol(GO:1901421) |
| 0.4 | 1.1 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.4 | 1.1 | GO:0060382 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.4 | 1.4 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.3 | 1.3 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.3 | 5.6 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.3 | 3.5 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.3 | 2.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.3 | 0.9 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 0.3 | 1.5 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.3 | 1.5 | GO:0048861 | oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.3 | 4.9 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.3 | 8.9 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.3 | 2.0 | GO:0060701 | negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) |
| 0.3 | 0.9 | GO:0015798 | myo-inositol transport(GO:0015798) |
| 0.3 | 1.1 | GO:0008215 | spermine metabolic process(GO:0008215) |
| 0.3 | 0.8 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 0.3 | 0.8 | GO:1904328 | regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764) |
| 0.3 | 2.2 | GO:0060685 | regulation of prostatic bud formation(GO:0060685) negative regulation of prostatic bud formation(GO:0060686) |
| 0.3 | 7.4 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.3 | 1.1 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.3 | 5.4 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.3 | 0.8 | GO:1903925 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 0.3 | 1.1 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 0.3 | 1.8 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.3 | 4.0 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.2 | 4.0 | GO:0021957 | corticospinal tract morphogenesis(GO:0021957) |
| 0.2 | 2.2 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.2 | 1.4 | GO:1904016 | response to Thyroglobulin triiodothyronine(GO:1904016) |
| 0.2 | 2.2 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.2 | 1.2 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.2 | 0.7 | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) |
| 0.2 | 0.6 | GO:0031393 | negative regulation of prostaglandin biosynthetic process(GO:0031393) |
| 0.2 | 1.4 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.2 | 1.2 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.2 | 1.6 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.2 | 1.6 | GO:0016139 | glycoside catabolic process(GO:0016139) |
| 0.2 | 2.2 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.2 | 2.4 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.2 | 7.6 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.2 | 4.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.2 | 0.5 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 0.2 | 0.3 | GO:1902263 | apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
| 0.2 | 2.5 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.2 | 0.8 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 0.2 | 0.5 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.2 | 0.8 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.1 | 1.0 | GO:0090235 | regulation of metaphase plate congression(GO:0090235) |
| 0.1 | 0.9 | GO:0098795 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.1 | 4.3 | GO:0006625 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 2.4 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.1 | 2.1 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.6 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.1 | 0.4 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.1 | 0.8 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.1 | 0.8 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
| 0.1 | 1.7 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.1 | 1.4 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.1 | 1.8 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 1.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 1.4 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.1 | 0.5 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.1 | 1.1 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.1 | 0.4 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.1 | 0.5 | GO:0072143 | renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144) |
| 0.1 | 10.1 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.1 | 0.7 | GO:0097052 | L-kynurenine metabolic process(GO:0097052) |
| 0.1 | 0.6 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.1 | 0.7 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 2.9 | GO:0017004 | cytochrome complex assembly(GO:0017004) |
| 0.1 | 0.7 | GO:0033489 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 0.1 | 1.0 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 2.7 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 0.9 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) |
| 0.1 | 5.1 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.1 | 3.6 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.1 | 1.8 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.1 | 8.0 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.1 | 7.2 | GO:0008542 | visual learning(GO:0008542) |
| 0.1 | 0.6 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.1 | 0.7 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.1 | 1.2 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.1 | 1.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 0.3 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.1 | 9.0 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.1 | 1.1 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.1 | 0.5 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.1 | 0.2 | GO:0002876 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876) |
| 0.1 | 1.4 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
| 0.1 | 0.2 | GO:0061364 | apoptotic process involved in luteolysis(GO:0061364) |
| 0.1 | 0.7 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.1 | 0.8 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 0.2 | GO:1901389 | regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389) |
| 0.1 | 0.5 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.1 | 2.5 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.1 | 0.7 | GO:1902414 | protein localization to cell junction(GO:1902414) |
| 0.1 | 0.2 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.1 | 0.2 | GO:0032903 | viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 0.1 | 0.8 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.1 | 1.6 | GO:0097435 | fibril organization(GO:0097435) |
| 0.1 | 0.9 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 7.0 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.1 | 1.3 | GO:1903846 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.1 | 1.1 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 1.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.6 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.0 | 0.4 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.9 | GO:0009650 | UV protection(GO:0009650) UV-damage excision repair(GO:0070914) |
| 0.0 | 0.4 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.0 | 1.2 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 0.7 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 1.7 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.0 | 3.7 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 0.4 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 0.1 | GO:0032815 | negative regulation of natural killer cell activation(GO:0032815) |
| 0.0 | 0.4 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 0.3 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.0 | 0.1 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.0 | 0.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 1.2 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 4.5 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 2.5 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 5.7 | GO:0030509 | BMP signaling pathway(GO:0030509) |
| 0.0 | 0.1 | GO:0046416 | D-amino acid metabolic process(GO:0046416) |
| 0.0 | 0.1 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.0 | 1.0 | GO:0097503 | sialylation(GO:0097503) |
| 0.0 | 1.8 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.0 | 0.1 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.0 | 0.2 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 0.4 | GO:0034311 | sphingosine metabolic process(GO:0006670) diol metabolic process(GO:0034311) |
| 0.0 | 0.2 | GO:0006772 | thiamine metabolic process(GO:0006772) |
| 0.0 | 0.2 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 1.5 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.0 | 0.4 | GO:0008212 | mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212) |
| 0.0 | 2.1 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 0.8 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 0.4 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.0 | 0.5 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.0 | 6.0 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 0.2 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.0 | 0.0 | GO:0000965 | mitochondrial RNA 3'-end processing(GO:0000965) |
| 0.0 | 0.2 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.0 | 1.0 | GO:0061462 | protein localization to lysosome(GO:0061462) |
| 0.0 | 0.6 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.0 | 0.9 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.1 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.0 | 0.3 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.0 | 2.0 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 1.2 | GO:0035065 | regulation of histone acetylation(GO:0035065) |
| 0.0 | 2.4 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 1.5 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.4 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.0 | 0.3 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.0 | 0.2 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.2 | GO:0043243 | positive regulation of protein complex disassembly(GO:0043243) |
| 0.0 | 0.6 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.0 | 0.1 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.0 | 0.4 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
| 0.0 | 0.5 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 0.1 | GO:0006127 | glycerophosphate shuttle(GO:0006127) |
| 0.0 | 0.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.6 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.0 | 0.6 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.2 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 0.1 | GO:0072526 | pyridine-containing compound catabolic process(GO:0072526) |
| 0.0 | 0.3 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.4 | GO:0006517 | protein deglycosylation(GO:0006517) |
| 0.0 | 0.3 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 0.2 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 0.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 8.9 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
| 1.6 | 11.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.7 | 2.2 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.7 | 8.0 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.6 | 7.1 | GO:0005638 | lamin filament(GO:0005638) |
| 0.6 | 1.9 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.6 | 4.9 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.5 | 3.8 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.5 | 4.3 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
| 0.5 | 5.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.5 | 7.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.4 | 1.6 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.4 | 7.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.3 | 5.1 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.3 | 1.2 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 0.3 | 1.5 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.3 | 2.6 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.3 | 3.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.3 | 4.1 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.3 | 2.2 | GO:0034464 | BBSome(GO:0034464) |
| 0.2 | 5.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 2.7 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.2 | 7.2 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.2 | 2.4 | GO:0070449 | elongin complex(GO:0070449) |
| 0.2 | 3.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 1.6 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.2 | 1.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 1.6 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 2.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 1.5 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.2 | 2.0 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.2 | 2.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.2 | 0.5 | GO:0005656 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.2 | 0.6 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.1 | 0.5 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.1 | 4.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.8 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 1.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 2.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 1.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 1.3 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.1 | 1.4 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.9 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.1 | 2.3 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.1 | 0.5 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 0.3 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.1 | 0.9 | GO:0032797 | SMN complex(GO:0032797) |
| 0.1 | 0.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 1.5 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.1 | 0.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 2.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 1.8 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 9.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 6.9 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 1.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 1.5 | GO:1902555 | endoribonuclease complex(GO:1902555) |
| 0.1 | 3.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 5.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 1.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 0.2 | GO:1990913 | sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917) |
| 0.1 | 4.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 1.1 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 6.3 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 0.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 0.3 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 5.2 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 2.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 5.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 1.1 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.1 | 1.2 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 1.0 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 2.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 1.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 13.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 2.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 14.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 5.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.9 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 1.5 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 15.9 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 1.3 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.0 | 0.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.1 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.1 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 2.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.6 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 6.1 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.0 | 1.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.1 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.0 | 1.7 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.3 | GO:0031901 | early endosome membrane(GO:0031901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.8 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 2.1 | 6.4 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
| 1.4 | 7.1 | GO:1990254 | keratin filament binding(GO:1990254) |
| 1.3 | 6.4 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 1.3 | 3.8 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 1.1 | 5.6 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 1.0 | 10.5 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.9 | 2.7 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.8 | 6.4 | GO:0016997 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 0.7 | 3.0 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.7 | 2.9 | GO:0016972 | flavin-linked sulfhydryl oxidase activity(GO:0016971) thiol oxidase activity(GO:0016972) |
| 0.7 | 11.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.6 | 1.8 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
| 0.6 | 4.1 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.6 | 2.9 | GO:0033906 | hyaluronoglucuronidase activity(GO:0033906) |
| 0.6 | 2.3 | GO:0050211 | procollagen galactosyltransferase activity(GO:0050211) |
| 0.6 | 2.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.5 | 1.6 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.5 | 1.5 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.3 | 13.2 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.3 | 4.0 | GO:0046790 | virion binding(GO:0046790) |
| 0.3 | 2.0 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.3 | 9.3 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.3 | 0.8 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.3 | 1.1 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.3 | 2.7 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.3 | 1.1 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.3 | 1.6 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.3 | 4.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.3 | 9.5 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.3 | 1.5 | GO:0032296 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.3 | 0.8 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.2 | 3.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.2 | 0.7 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.2 | 3.1 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.2 | 2.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 0.8 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.2 | 0.6 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.2 | 2.4 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.2 | 0.5 | GO:0030290 | sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428) |
| 0.2 | 0.5 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.2 | 0.7 | GO:0004420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 0.2 | 2.1 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.2 | 4.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.2 | 0.6 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.2 | 1.1 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.1 | 0.9 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 8.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.4 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.1 | 0.4 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
| 0.1 | 0.4 | GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798) |
| 0.1 | 2.8 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.1 | 9.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 0.8 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.1 | 1.1 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.9 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
| 0.1 | 9.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 2.3 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.1 | 2.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 3.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 5.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 2.1 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 0.3 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.1 | 0.4 | GO:0070363 | mitochondrial light strand promoter sense binding(GO:0070363) |
| 0.1 | 0.7 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 0.6 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.1 | 2.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 3.5 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 0.1 | 3.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 0.4 | GO:0047238 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238) |
| 0.1 | 1.4 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 1.6 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 1.5 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 2.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 1.3 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 0.4 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.1 | 2.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 3.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 0.2 | GO:0002135 | CTP binding(GO:0002135) |
| 0.1 | 0.7 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.1 | 0.6 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 1.1 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 0.5 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 1.2 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 0.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 4.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 1.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 0.7 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.0 | 0.6 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 1.2 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.0 | 0.2 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.0 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.0 | 0.9 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 0.2 | GO:0004802 | transketolase activity(GO:0004802) |
| 0.0 | 2.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.9 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.5 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 0.2 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.0 | 0.4 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 0.8 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.0 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.1 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.0 | 0.5 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 4.3 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 0.3 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.0 | 2.2 | GO:0070405 | ammonium ion binding(GO:0070405) |
| 0.0 | 0.4 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.0 | 8.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.1 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.0 | 4.1 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 3.1 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.1 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.0 | 0.1 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.1 | GO:0052590 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.0 | 0.1 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 0.5 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 0.1 | GO:0005298 | proline:sodium symporter activity(GO:0005298) |
| 0.0 | 0.7 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.3 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.1 | GO:0004803 | transposase activity(GO:0004803) |
| 0.0 | 0.1 | GO:0002060 | purine nucleobase binding(GO:0002060) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 20.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 10.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 7.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 5.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 9.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 5.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 29.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 1.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 1.9 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 4.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 6.1 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 4.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 5.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 18.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 4.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.6 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 0.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 4.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.3 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 8.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.4 | 7.4 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.4 | 14.6 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 4.0 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.3 | 6.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 3.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 11.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 1.5 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.2 | 8.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 0.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 1.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 6.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 3.8 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.1 | 2.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 4.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 3.9 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 11.1 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.1 | 7.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 4.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 4.3 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 1.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 3.1 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 2.7 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 4.5 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.1 | 1.9 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.1 | 1.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 1.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 9.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 1.5 | REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION | Genes involved in Glucagon signaling in metabolic regulation |
| 0.1 | 0.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 6.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 1.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.0 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.6 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 2.1 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.9 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.6 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.5 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.4 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.4 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.0 | 1.4 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 0.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.7 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.4 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 1.0 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |