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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RFX5

Z-value: 2.49

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.18 RFX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg38_v1_chr1_-_151347234_1513473260.518.8e-16Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_32589833 86.52 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_+_33075952 80.18 ENST00000418931.7
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr5_-_150412743 76.68 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74
CD74 molecule
chr6_-_32530268 75.21 ENST00000374975.4
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr6_-_32953017 69.74 ENST00000395305.7
ENST00000374843.9
ENST00000395303.7
ENST00000429234.1
HLA-DMA
ENSG00000248993.1
major histocompatibility complex, class II, DM alpha
novel protein
chr6_+_32854179 47.10 ENST00000374859.3
PSMB9
proteasome 20S subunit beta 9
chr6_+_30489501 46.41 ENST00000376630.5
HLA-E
major histocompatibility complex, class I, E
chr6_-_32666648 40.14 ENST00000399082.7
ENST00000399079.7
ENST00000374943.8
ENST00000434651.6
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_-_32844643 38.98 ENST00000374881.3
PSMB8
proteasome 20S subunit beta 8
chr6_+_32844789 38.15 ENST00000414474.5
PSMB9
proteasome 20S subunit beta 9
chr6_-_32763522 35.56 ENST00000435145.6
ENST00000437316.7
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_-_32941018 31.91 ENST00000418107.3
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_31357171 29.49 ENST00000412585.7
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr6_-_32853618 27.22 ENST00000354258.5
TAP1
transporter 1, ATP binding cassette subfamily B member
chr6_-_32853813 26.86 ENST00000643049.2
TAP1
transporter 1, ATP binding cassette subfamily B member
chr6_-_32816910 19.43 ENST00000447394.1
ENST00000438763.7
HLA-DOB
major histocompatibility complex, class II, DO beta
chr11_-_6619353 18.07 ENST00000642892.1
ENST00000645620.1
ENST00000533371.6
ENST00000647152.1
ENST00000644810.1
ENST00000299427.12
ENST00000682424.1
ENST00000644218.1
ENST00000528657.2
ENST00000531754.2
TPP1
tripeptidyl peptidase 1
chr6_-_32763466 16.95 ENST00000427449.1
ENST00000411527.5
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_+_26383176 16.54 ENST00000416795.6
ENST00000494184.1
BTN2A2
butyrophilin subfamily 2 member A2
chr6_+_26365215 16.01 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
BTN3A2
butyrophilin subfamily 3 member A2
chr6_+_26365159 16.00 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
BTN3A2
butyrophilin subfamily 3 member A2
chr6_+_26365176 15.83 ENST00000377708.7
BTN3A2
butyrophilin subfamily 3 member A2
chr1_+_248838211 14.84 ENST00000306562.8
ZNF672
zinc finger protein 672
chr15_+_44711487 14.33 ENST00000544417.5
ENST00000559916.1
ENST00000648006.3
B2M
beta-2-microglobulin
chr11_+_7987314 13.96 ENST00000531572.2
ENST00000651655.1
EIF3F
eukaryotic translation initiation factor 3 subunit F
chr6_+_26457904 13.35 ENST00000541522.5
BTN2A1
butyrophilin subfamily 2 member A1
chr6_+_26402237 13.04 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
BTN3A1
butyrophilin subfamily 3 member A1
chr6_+_26457941 12.72 ENST00000493173.1
ENST00000312541.10
ENST00000429381.5
ENST00000469185.5
BTN2A1
butyrophilin subfamily 2 member A1
chr6_+_26440472 12.68 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr6_-_132757883 10.11 ENST00000525289.5
ENST00000326499.11
VNN2
vanin 2
chr6_+_26383090 8.71 ENST00000469230.5
ENST00000490025.5
ENST00000352867.6
ENST00000356709.9
ENST00000493275.5
ENST00000472507.5
ENST00000482536.5
ENST00000432533.6
ENST00000482842.1
BTN2A2
butyrophilin subfamily 2 member A2
chr10_-_80172839 8.53 ENST00000265447.8
ANXA11
annexin A11
chr19_+_44914833 6.69 ENST00000589078.1
ENST00000586638.5
APOC1
apolipoprotein C1
chr2_-_241149435 6.21 ENST00000358649.8
ENST00000452907.1
ENST00000403638.7
ENST00000234040.9
ENST00000415234.1
PASK
PAS domain containing serine/threonine kinase
chr3_+_196739839 5.02 ENST00000327134.7
PAK2
p21 (RAC1) activated kinase 2
chr19_+_44914702 4.29 ENST00000592885.5
ENST00000589781.1
APOC1
apolipoprotein C1
chr11_-_72722302 4.24 ENST00000334211.12
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr12_-_52652207 3.89 ENST00000309680.4
KRT2
keratin 2
chr4_-_99290975 3.45 ENST00000209668.3
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr6_+_26402289 3.40 ENST00000414912.2
BTN3A1
butyrophilin subfamily 3 member A1
chr5_-_60488055 3.16 ENST00000505507.6
ENST00000515835.2
ENST00000502484.6
PDE4D
phosphodiesterase 4D
chr6_-_30213379 3.09 ENST00000418026.1
ENST00000454678.7
ENST00000416596.5
ENST00000453195.5
TRIM26
tripartite motif containing 26
chr4_-_142305935 2.93 ENST00000511838.5
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr6_-_24666591 2.45 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr6_-_24666854 2.42 ENST00000378198.9
TDP2
tyrosyl-DNA phosphodiesterase 2
chr1_+_181033887 2.37 ENST00000684662.1
ENST00000434571.7
ENST00000367580.6
ENST00000617803.5
ENST00000683652.1
ENST00000367579.7
ENST00000282990.10
MR1
major histocompatibility complex, class I-related
chr4_-_142305826 2.31 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr16_+_67347391 1.97 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr19_-_39833615 1.92 ENST00000593685.5
ENST00000600611.5
DYRK1B
dual specificity tyrosine phosphorylation regulated kinase 1B
chr1_+_36084079 1.45 ENST00000207457.8
TEKT2
tektin 2
chr16_-_57971121 1.41 ENST00000251102.13
CNGB1
cyclic nucleotide gated channel subunit beta 1
chr16_+_67347358 1.26 ENST00000563189.5
LRRC36
leucine rich repeat containing 36
chr19_+_3933581 1.01 ENST00000593949.1
NMRK2
nicotinamide riboside kinase 2
chr1_-_202967229 0.83 ENST00000367249.9
CYB5R1
cytochrome b5 reductase 1
chr11_+_24497155 0.68 ENST00000529015.5
ENST00000533227.5
LUZP2
leucine zipper protein 2
chr11_+_24496988 0.62 ENST00000336930.11
LUZP2
leucine zipper protein 2
chr19_+_49527988 0.46 ENST00000270645.8
RCN3
reticulocalbin 3
chr19_+_35612729 0.39 ENST00000203166.10
HAUS5
HAUS augmin like complex subunit 5
chr8_-_98294195 0.18 ENST00000430223.7
NIPAL2
NIPA like domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
47.0 188.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
27.0 54.1 GO:0046967 cytosol to ER transport(GO:0046967)
25.6 76.7 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
20.2 60.7 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
6.5 19.4 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
3.7 29.5 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
2.7 11.0 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
2.1 64.3 GO:0072643 interferon-gamma secretion(GO:0072643)
2.0 253.1 GO:0031295 T cell costimulation(GO:0031295)
1.9 25.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
1.2 117.9 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
1.1 4.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
1.0 6.2 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.8 10.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.8 14.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.4 18.1 GO:0043171 peptide catabolic process(GO:0043171)
0.4 8.5 GO:0032506 cytokinetic process(GO:0032506)
0.4 3.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.3 3.5 GO:0006069 ethanol oxidation(GO:0006069)
0.2 3.9 GO:0003334 keratinocyte development(GO:0003334) keratinocyte migration(GO:0051546)
0.2 3.1 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 1.5 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 1.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 12.7 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 2.4 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 5.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.9 GO:0060612 adipose tissue development(GO:0060612)
0.0 1.0 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 4.9 GO:0006302 double-strand break repair(GO:0006302)
0.0 0.8 GO:0015701 bicarbonate transport(GO:0015701)
0.0 22.4 GO:0006629 lipid metabolic process(GO:0006629)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
28.0 532.3 GO:0042613 MHC class II protein complex(GO:0042613)
17.7 124.2 GO:1990111 spermatoproteasome complex(GO:1990111)
10.8 54.1 GO:0042825 TAP complex(GO:0042825)
8.4 92.6 GO:0042611 MHC protein complex(GO:0042611)
1.4 14.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.5 1.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.4 11.0 GO:0042627 chylomicron(GO:0042627)
0.1 26.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 4.9 GO:0016235 aggresome(GO:0016235)
0.1 3.9 GO:0045095 keratin filament(GO:0045095)
0.1 10.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.5 GO:0036126 sperm flagellum(GO:0036126)
0.0 107.2 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.4 71.9 GO:0032395 MHC class II receptor activity(GO:0032395)
11.0 76.7 GO:0042289 MHC class II protein binding(GO:0042289)
10.6 412.0 GO:0042605 peptide antigen binding(GO:0042605)
4.4 124.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
4.4 110.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
3.6 18.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
2.5 10.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.6 4.9 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
1.2 11.0 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.0 5.2 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.4 3.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 3.9 GO:0030280 structural constituent of epidermis(GO:0030280)
0.3 1.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.3 14.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.3 1.0 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.2 4.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.2 2.4 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 5.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 3.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 1.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 6.2 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 86.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 54.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 14.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 5.0 PID MYC PATHWAY C-MYC pathway
0.1 4.9 PID CD40 PATHWAY CD40/CD40L signaling
0.0 4.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 8.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 241.9 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
4.0 43.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.5 54.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.8 197.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.7 117.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 3.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 5.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 18.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 5.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 14.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases