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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RORA

Z-value: 6.74

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Transcription factors associated with RORA

Gene Symbol Gene ID Gene Info
RORA
ENSG00000069667.16 RORA

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORAhg38_v1_chr15_-_61229297_61229306,
hg38_v1_chr15_-_60592507_60592545		-0.111.2e-01Click!

Activity profile of RORA motif

Sorted Z-values of RORA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr20_+_3796288 28.87 ENST00000439880.6
ENST00000245960.10
CDC25B
cell division cycle 25B
chr2_+_74206384 24.73 ENST00000678623.1
ENST00000678731.1
MTHFD2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr14_-_58427114 24.53 ENST00000556007.6
TIMM9
translocase of inner mitochondrial membrane 9
chrX_-_130165699 21.26 ENST00000676328.1
ENST00000675857.1
ENST00000675427.1
ENST00000675092.1
AIFM1
apoptosis inducing factor mitochondria associated 1
chr14_-_58427158 19.13 ENST00000555097.1
ENST00000556367.6
ENST00000555404.5
TIMM9
translocase of inner mitochondrial membrane 9
chr1_-_150234668 18.80 ENST00000616917.4
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr17_+_51153551 18.69 ENST00000393196.8
ENST00000336097.7
ENST00000480143.5
ENST00000511355.5
ENST00000393193.6
ENST00000376392.10
NME1
NME1-NME2
NME/NM23 nucleoside diphosphate kinase 1
NME1-NME2 readthrough
chr12_-_52926459 18.66 ENST00000552150.5
KRT8
keratin 8
chr6_-_41071825 18.26 ENST00000468811.5
OARD1
O-acyl-ADP-ribose deacylase 1
chr17_+_51153628 18.18 ENST00000555572.1
ENST00000013034.3
NME1-NME2
NME1
NME1-NME2 readthrough
NME/NM23 nucleoside diphosphate kinase 1
chr7_+_128758947 17.99 ENST00000493278.1
CALU
calumenin
chrX_-_130165664 16.73 ENST00000535724.6
ENST00000346424.6
ENST00000676436.1
AIFM1
apoptosis inducing factor mitochondria associated 1
chr7_+_112423137 16.08 ENST00000005558.8
ENST00000621379.4
IFRD1
interferon related developmental regulator 1
chr10_+_92291155 15.46 ENST00000358935.3
MARCHF5
membrane associated ring-CH-type finger 5
chr8_+_144095054 14.79 ENST00000318911.5
CYC1
cytochrome c1
chr14_-_58427134 14.00 ENST00000555930.6
TIMM9
translocase of inner mitochondrial membrane 9
chr9_-_128204218 13.87 ENST00000634901.1
ENST00000372948.7
CIZ1
CDKN1A interacting zinc finger protein 1
chr1_-_153550083 13.82 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr3_-_142029108 13.61 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr10_-_63269057 12.95 ENST00000542921.5
JMJD1C
jumonji domain containing 1C
chr3_-_113746218 11.89 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
NAA50
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr2_-_206159509 11.54 ENST00000423725.5
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr2_-_86194972 11.18 ENST00000254636.9
IMMT
inner membrane mitochondrial protein
chr3_-_113746185 10.91 ENST00000616174.1
NAA50
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr2_-_208254232 10.62 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
IDH1
isocitrate dehydrogenase (NADP(+)) 1
chrX_-_130165825 10.60 ENST00000675240.1
ENST00000319908.8
ENST00000674546.1
ENST00000287295.8
AIFM1
apoptosis inducing factor mitochondria associated 1
chr2_+_197500398 10.57 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr16_+_21953341 10.54 ENST00000268379.9
ENST00000561553.5
ENST00000565331.5
UQCRC2
ubiquinol-cytochrome c reductase core protein 2
chr16_-_47143934 10.45 ENST00000562435.6
NETO2
neuropilin and tolloid like 2
chr11_+_67605488 10.43 ENST00000533876.1
ENST00000647561.1
ENSG00000255119.1
NDUFV1
novel transcript
NADH:ubiquinone oxidoreductase core subunit V1
chr2_-_197499826 10.39 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
HSPD1
heat shock protein family D (Hsp60) member 1
chr1_-_33036927 9.89 ENST00000354858.11
AK2
adenylate kinase 2
chr19_-_3546306 9.75 ENST00000398558.8
MFSD12
major facilitator superfamily domain containing 12
chr2_-_206159410 9.51 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr2_-_197499857 9.18 ENST00000428204.6
ENST00000678170.1
ENST00000676933.1
ENST00000678621.1
HSPD1
heat shock protein family D (Hsp60) member 1
chr2_+_206159580 9.05 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr18_-_21704763 8.60 ENST00000580981.5
ENST00000289119.7
ABHD3
abhydrolase domain containing 3, phospholipase
chr1_-_205750167 8.54 ENST00000367142.5
NUCKS1
nuclear casein kinase and cyclin dependent kinase substrate 1
chr2_+_206159884 8.53 ENST00000392222.7
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr18_+_9102671 8.34 ENST00000497577.2
ENST00000318388.11
ENST00000579126.5
ENST00000578850.1
NDUFV2
ENSG00000265257.5
NADH:ubiquinone oxidoreductase core subunit V2
novel transcript
chr10_-_101818425 8.28 ENST00000361464.8
ENST00000439817.5
OGA
O-GlcNAcase
chr9_+_131228109 8.14 ENST00000498010.2
ENST00000476004.5
ENST00000528406.1
NUP214
nucleoporin 214
chr1_-_33036840 8.10 ENST00000548033.5
ENST00000487289.1
ENST00000626911.1
ENST00000673291.1
ENST00000480134.5
ENST00000373449.7
ENST00000672715.1
ENST00000467905.5
ENST00000629371.2
AK2
adenylate kinase 2
chr10_-_101818405 7.98 ENST00000357797.9
ENST00000370094.7
OGA
O-GlcNAcase
chr3_-_50322733 7.92 ENST00000428028.1
ENST00000357750.9
HYAL2
hyaluronidase 2
chr19_-_39435627 7.85 ENST00000599705.1
RPS16
ribosomal protein S16
chr3_-_9986682 7.75 ENST00000429759.5
EMC3
ER membrane protein complex subunit 3
chr7_-_123557679 7.75 ENST00000677264.1
ENST00000471770.5
ENST00000676730.1
ENST00000677391.1
ENST00000677251.1
ENST00000470123.2
ENST00000679163.1
ENST00000676614.1
ENST00000378795.9
ENST00000676516.1
ENST00000355749.7
ENST00000678090.1
NDUFA5
NADH:ubiquinone oxidoreductase subunit A5
chr19_-_39335999 7.68 ENST00000602185.5
ENST00000598034.5
ENST00000601387.5
ENST00000595636.1
ENST00000253054.12
ENST00000594700.5
ENST00000597595.6
GMFG
glia maturation factor gamma
chr5_-_140647590 7.65 ENST00000252102.9
ENST00000512088.1
NDUFA2
NADH:ubiquinone oxidoreductase subunit A2
chr17_-_44067585 7.51 ENST00000591247.6
LSM12
LSM12 homolog
chr7_-_128343823 7.45 ENST00000415472.6
ENST00000478061.5
ENST00000223073.6
ENST00000459726.1
RBM28
RNA binding motif protein 28
chr17_-_50707855 7.45 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr2_+_197500371 7.45 ENST00000409468.1
ENST00000233893.10
HSPE1
heat shock protein family E (Hsp10) member 1
chr1_-_31938302 7.34 ENST00000647444.2
PTP4A2
protein tyrosine phosphatase 4A2
chr18_-_12377200 6.76 ENST00000269143.8
AFG3L2
AFG3 like matrix AAA peptidase subunit 2
chr3_-_50322759 6.66 ENST00000442581.1
ENST00000447092.5
HYAL2
hyaluronidase 2
chr10_+_70815889 6.65 ENST00000373202.8
SGPL1
sphingosine-1-phosphate lyase 1
chr7_-_45111673 6.62 ENST00000461363.1
ENST00000258770.8
ENST00000495078.1
ENST00000494076.5
ENST00000478532.5
ENST00000361278.7
TBRG4
transforming growth factor beta regulator 4
chr12_-_6375209 6.43 ENST00000360168.7
SCNN1A
sodium channel epithelial 1 subunit alpha
chr11_-_112086727 6.02 ENST00000504148.3
ENST00000541231.1
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B
chr2_+_108621260 5.97 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr11_+_118401586 5.91 ENST00000649464.1
ENST00000648261.1
ENST00000300688.8
ENST00000533172.5
ENST00000524422.1
ENSG00000285827.1
ATP5MG
novel protein
ATP synthase membrane subunit g
chr19_+_46347063 5.70 ENST00000012443.9
ENST00000391919.1
PPP5C
protein phosphatase 5 catalytic subunit
chr1_+_161202147 5.69 ENST00000392179.5
ENST00000678511.1
ENST00000677453.1
ENST00000678783.1
ENST00000679218.1
ENST00000676972.1
NDUFS2
NADH:ubiquinone oxidoreductase core subunit S2
chr11_-_111871271 5.50 ENST00000398006.6
ALG9
ALG9 alpha-1,2-mannosyltransferase
chr3_-_42804451 5.38 ENST00000418900.6
ENST00000321331.12
ENST00000430190.5
ENST00000648550.1
HIGD1A
ENSG00000280571.2
HIG1 hypoxia inducible domain family member 1A
novel protein
chr14_+_103121457 5.30 ENST00000333007.8
TNFAIP2
TNF alpha induced protein 2
chr3_+_155870623 5.30 ENST00000295920.7
ENST00000496455.7
GMPS
guanine monophosphate synthase
chr11_+_112086853 5.19 ENST00000528182.5
ENST00000528048.5
ENST00000375549.8
ENST00000528021.6
ENST00000526592.5
ENST00000525291.5
SDHD
succinate dehydrogenase complex subunit D
chr6_-_96897853 4.82 ENST00000316149.8
NDUFAF4
NADH:ubiquinone oxidoreductase complex assembly factor 4
chr5_+_140647802 4.80 ENST00000417647.7
ENST00000507593.5
ENST00000508301.5
IK
IK cytokine
chr1_+_103617427 4.59 ENST00000423678.2
ENST00000414303.7
AMY2A
amylase alpha 2A
chr17_+_44070857 4.51 ENST00000591696.1
G6PC3
glucose-6-phosphatase catalytic subunit 3
chr3_-_24494791 4.43 ENST00000431815.5
ENST00000356447.9
ENST00000418247.1
ENST00000416420.5
ENST00000396671.7
THRB
thyroid hormone receptor beta
chr7_-_151080833 4.36 ENST00000353841.6
ENST00000482571.2
FASTK
Fas activated serine/threonine kinase
chr18_+_61333424 4.30 ENST00000262717.9
CDH20
cadherin 20
chr11_-_64744102 4.23 ENST00000431822.5
ENST00000394432.8
ENST00000377486.7
RASGRP2
RAS guanyl releasing protein 2
chr7_-_151080787 4.10 ENST00000540185.5
ENST00000297532.11
FASTK
Fas activated serine/threonine kinase
chr17_-_4555371 3.92 ENST00000254718.9
ENST00000381556.6
MYBBP1A
MYB binding protein 1a
chr10_+_73998104 3.88 ENST00000372755.7
ENST00000211998.10
VCL
vinculin
chr1_+_212565334 3.85 ENST00000366981.8
ENST00000366987.6
ATF3
activating transcription factor 3
chr11_-_33717409 3.74 ENST00000651485.1
CD59
CD59 molecule (CD59 blood group)
chr3_+_179604785 3.58 ENST00000611971.4
ENST00000493866.5
ENST00000259037.8
ENST00000472629.5
ENST00000482604.5
NDUFB5
NADH:ubiquinone oxidoreductase subunit B5
chr2_+_70087468 3.34 ENST00000303577.7
PCBP1
poly(rC) binding protein 1
chr3_-_24494842 3.29 ENST00000646209.2
THRB
thyroid hormone receptor beta
chr12_-_56645955 3.19 ENST00000552959.5
ENST00000551020.5
ENST00000553007.2
ENST00000262030.8
ATP5F1B
ATP synthase F1 subunit beta
chr3_-_27456743 3.10 ENST00000295736.9
ENST00000428386.5
ENST00000428179.1
SLC4A7
solute carrier family 4 member 7
chr12_-_120265719 3.07 ENST00000637617.2
ENST00000267257.11
ENST00000228307.11
ENST00000424649.6
PXN
paxillin
chr15_-_74725370 2.97 ENST00000567032.5
ENST00000564596.5
ENST00000566503.1
ENST00000395049.8
ENST00000379727.8
ENST00000617691.4
ENST00000395048.6
CYP1A1
cytochrome P450 family 1 subfamily A member 1
chr12_+_93569814 2.82 ENST00000340600.6
SOCS2
suppressor of cytokine signaling 2
chr5_+_40679907 2.76 ENST00000302472.4
PTGER4
prostaglandin E receptor 4
chr10_+_97426162 2.75 ENST00000334828.6
PGAM1
phosphoglycerate mutase 1
chr9_-_93453540 2.72 ENST00000375412.11
FAM120AOS
family with sequence similarity 120A opposite strand
chr3_-_24494875 2.70 ENST00000644321.1
THRB
thyroid hormone receptor beta
chr16_-_30526518 2.67 ENST00000380412.7
ZNF768
zinc finger protein 768
chr8_-_99893697 2.44 ENST00000518171.5
ENST00000520468.7
COX6C
cytochrome c oxidase subunit 6C
chr15_+_78149354 2.16 ENST00000558554.5
ENST00000557826.5
ENST00000561279.5
ENST00000299518.7
ENST00000559186.5
ENST00000560770.5
ENST00000559881.5
ENST00000559205.1
ENST00000629769.2
IDH3A
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
chr3_-_24495532 2.12 ENST00000643772.1
ENST00000642307.1
ENST00000645139.1
THRB
thyroid hormone receptor beta
chr3_+_113747022 2.00 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATP6V1A
ATPase H+ transporting V1 subunit A
chr5_+_170353480 1.96 ENST00000377360.8
KCNIP1
potassium voltage-gated channel interacting protein 1
chr20_+_50510321 1.67 ENST00000541713.5
ENST00000371621.5
PTPN1
protein tyrosine phosphatase non-receptor type 1
chr9_-_35685462 1.53 ENST00000607559.1
TPM2
tropomyosin 2
chr2_+_10420021 1.46 ENST00000422133.1
HPCAL1
hippocalcin like 1
chr17_+_42844573 1.39 ENST00000253799.8
ENST00000452774.2
AOC2
amine oxidase copper containing 2
chr19_+_15949008 1.18 ENST00000322107.1
OR10H4
olfactory receptor family 10 subfamily H member 4
chr1_+_45913647 1.06 ENST00000674079.1
MAST2
microtubule associated serine/threonine kinase 2
chr1_+_103750406 1.05 ENST00000370079.3
AMY1C
amylase alpha 1C
chr19_-_11578937 1.01 ENST00000592659.1
ENST00000592828.6
ENST00000218758.9
ENST00000412435.6
ACP5
acid phosphatase 5, tartrate resistant
chr1_-_185317234 0.99 ENST00000367498.8
IVNS1ABP
influenza virus NS1A binding protein
chrX_-_21758021 0.96 ENST00000646008.1
SMPX
small muscle protein X-linked
chr5_-_88785493 0.95 ENST00000503554.4
MEF2C
myocyte enhancer factor 2C
chrX_-_21758097 0.95 ENST00000379494.4
SMPX
small muscle protein X-linked
chr20_-_37527862 0.92 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP
BLCAP apoptosis inducing factor
chr8_-_99893135 0.85 ENST00000524245.5
COX6C
cytochrome c oxidase subunit 6C
chr12_-_6606642 0.82 ENST00000545584.2
ENST00000545942.6
CHD4
chromodomain helicase DNA binding protein 4
chrX_-_109482075 0.79 ENST00000218006.3
GUCY2F
guanylate cyclase 2F, retinal
chr17_-_2711633 0.78 ENST00000435359.5
CLUH
clustered mitochondria homolog
chr8_-_99893622 0.77 ENST00000520271.5
ENST00000522940.5
ENST00000523016.1
ENST00000517682.6
ENST00000297564.6
COX6C
cytochrome c oxidase subunit 6C
chr8_-_133060347 0.66 ENST00000427060.6
SLA
Src like adaptor
chr6_-_41735557 0.61 ENST00000373033.6
TFEB
transcription factor EB
chr14_+_69484722 0.50 ENST00000322564.9
PLEKHD1
pleckstrin homology and coiled-coil domain containing D1
chr1_+_165631199 0.49 ENST00000367888.8
ENST00000367889.8
ENST00000367885.5
ENST00000367884.6
MGST3
microsomal glutathione S-transferase 3
chr19_-_50837213 0.47 ENST00000326856.8
KLK15
kallikrein related peptidase 15
chr16_+_56865202 0.47 ENST00000566786.5
ENST00000438926.6
ENST00000563236.6
ENST00000262502.5
SLC12A3
solute carrier family 12 member 3
chr18_-_46098275 0.46 ENST00000589252.5
ENST00000398752.11
ENST00000590665.5
ENST00000593152.6
ATP5F1A
ATP synthase F1 subunit alpha
chr10_+_102419189 0.33 ENST00000432590.5
FBXL15
F-box and leucine rich repeat protein 15
chr12_+_93570381 0.14 ENST00000549206.5
SOCS2
suppressor of cytokine signaling 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 48.6 GO:1904045 cellular response to aldosterone(GO:1904045)
6.5 19.6 GO:0002368 B cell cytokine production(GO:0002368)
6.4 57.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
6.0 18.0 GO:0006172 ADP biosynthetic process(GO:0006172)
5.4 16.1 GO:0007518 myoblast fate determination(GO:0007518)
3.7 14.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
3.5 10.6 GO:0006097 glyoxylate cycle(GO:0006097)
2.9 14.6 GO:0070295 transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295)
2.8 8.5 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
2.6 10.5 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
2.6 28.9 GO:0007144 female meiosis I(GO:0007144)
1.8 36.9 GO:0006228 UTP biosynthetic process(GO:0006228)
1.8 12.5 GO:0008050 negative regulation of female receptivity(GO:0007621) female courtship behavior(GO:0008050)
1.7 5.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.7 6.8 GO:0034982 mitochondrial protein processing(GO:0034982)
1.5 22.8 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
1.3 18.7 GO:0051599 response to hydrostatic pressure(GO:0051599)
1.3 3.9 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
1.1 5.3 GO:0006177 GMP biosynthetic process(GO:0006177)
1.0 3.0 GO:0043449 cellular alkene metabolic process(GO:0043449)
1.0 7.7 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
1.0 67.8 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.9 11.2 GO:0042407 cristae formation(GO:0042407)
0.9 2.8 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.8 24.7 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.7 3.7 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
0.7 4.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.6 4.5 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.6 13.0 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.5 5.3 GO:0051601 exocyst localization(GO:0051601)
0.5 3.9 GO:2000210 positive regulation of anoikis(GO:2000210)
0.5 7.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.5 2.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.4 4.9 GO:0033327 Leydig cell differentiation(GO:0033327)
0.4 7.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.4 5.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.4 6.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.4 13.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 18.8 GO:0043486 histone exchange(GO:0043486)
0.3 1.7 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.3 5.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 3.9 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.2 1.0 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 7.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 3.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 11.4 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.2 3.0 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 8.1 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 8.6 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 3.1 GO:0007172 signal complex assembly(GO:0007172)
0.2 6.0 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 0.8 GO:0072553 terminal button organization(GO:0072553)
0.1 3.1 GO:0060117 auditory receptor cell development(GO:0060117)
0.1 6.4 GO:0050909 sensory perception of taste(GO:0050909)
0.1 13.7 GO:0006414 translational elongation(GO:0006414)
0.1 1.1 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 2.0 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 8.8 GO:0045333 cellular respiration(GO:0045333)
0.1 0.8 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 13.8 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 5.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0 10.6 GO:0006457 protein folding(GO:0006457)
0.0 10.6 GO:0042278 purine nucleoside metabolic process(GO:0042278)
0.0 1.4 GO:0009712 catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712)
0.0 0.9 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.7 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 3.2 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.5 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 1.0 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 1.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.6 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 57.7 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
5.9 29.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
3.3 22.8 GO:0031415 NatA complex(GO:0031415)
2.3 6.8 GO:0005745 m-AAA complex(GO:0005745)
2.2 19.6 GO:0046696 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) lipopolysaccharide receptor complex(GO:0046696)
2.0 8.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
1.9 25.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.9 11.2 GO:0061617 MICOS complex(GO:0061617)
1.8 18.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.6 17.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.5 6.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.3 3.9 GO:1990622 CHOP-ATF3 complex(GO:1990622)
1.0 5.2 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.0 18.8 GO:0000812 Swr1 complex(GO:0000812)
0.9 7.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.8 18.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.8 5.7 GO:1990635 proximal dendrite(GO:1990635)
0.7 66.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.6 33.6 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 18.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 1.9 GO:0005927 muscle tendon junction(GO:0005927)
0.3 5.3 GO:0000145 exocyst(GO:0000145)
0.3 1.7 GO:0097443 sorting endosome(GO:0097443)
0.3 36.9 GO:0005882 intermediate filament(GO:0005882)
0.2 10.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 3.9 GO:0005916 fascia adherens(GO:0005916)
0.2 4.8 GO:0070469 respiratory chain(GO:0070469)
0.2 2.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 28.5 GO:0000922 spindle pole(GO:0000922)
0.1 7.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 42.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 3.1 GO:0032420 stereocilium(GO:0032420)
0.1 13.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 9.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 10.4 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 4.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 8.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 20.1 GO:0000785 chromatin(GO:0000785)
0.0 6.6 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 24.7 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
4.0 48.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
3.5 10.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
3.3 19.6 GO:0034186 apolipoprotein A-I binding(GO:0034186)
2.9 14.6 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
2.9 8.6 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
2.6 5.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
2.3 36.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
1.6 22.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
1.5 4.6 GO:0004556 alpha-amylase activity(GO:0004556)
1.5 4.5 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.4 29.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.4 5.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.2 18.0 GO:0004017 adenylate kinase activity(GO:0004017)
1.0 7.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.8 12.5 GO:0070324 thyroid hormone binding(GO:0070324)
0.8 7.3 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.7 33.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 13.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.7 13.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.7 17.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.6 3.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.5 2.7 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.5 2.2 GO:0004449 isocitrate dehydrogenase activity(GO:0004448) isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.4 6.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.4 58.6 GO:0008565 protein transporter activity(GO:0008565)
0.4 3.0 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.3 1.4 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.3 4.8 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.3 6.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 2.8 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.2 19.1 GO:0019213 deacetylase activity(GO:0019213)
0.2 3.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 18.3 GO:0009055 electron carrier activity(GO:0009055)
0.2 18.7 GO:0097110 scaffold protein binding(GO:0097110)
0.2 5.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 10.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.2 3.3 GO:0098847 sequence-specific single stranded DNA binding(GO:0098847)
0.2 24.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 10.4 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 3.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 16.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.7 GO:0001848 complement binding(GO:0001848)
0.1 3.1 GO:0017166 vinculin binding(GO:0017166)
0.1 2.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.0 GO:0008199 ferric iron binding(GO:0008199)
0.1 2.0 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 8.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 1.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 7.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 7.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 23.8 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.5 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 3.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 28.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.1 36.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.6 19.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 48.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 19.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 12.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 8.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 7.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 6.6 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 13.6 PID E2F PATHWAY E2F transcription factor network
0.1 4.7 PID IGF1 PATHWAY IGF1 pathway
0.1 3.9 PID RHOA PATHWAY RhoA signaling pathway
0.1 6.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 3.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.1 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.0 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 5.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 13.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.8 PID P73PATHWAY p73 transcription factor network
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 11.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 54.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.7 98.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
1.0 28.9 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.0 82.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.6 14.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 5.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.4 10.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 5.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3 12.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 6.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.2 5.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 6.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 3.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 19.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.9 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 7.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 10.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 17.6 REACTOME TRANSLATION Genes involved in Translation
0.1 3.7 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 2.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 3.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 11.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway