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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RORC

Z-value: 0.35

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.19 RORC

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg38_v1_chr1_-_151826085_151826108,
hg38_v1_chr1_-_151831768_151831833		0.073.3e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_7060676 8.12 ENST00000617865.4
ENST00000402681.7
ENST00000360817.10
C1S
complement C1s
chr1_-_153550083 2.59 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr1_+_103655760 2.55 ENST00000370083.9
AMY1A
amylase alpha 1A
chr12_+_93569814 2.00 ENST00000340600.6
SOCS2
suppressor of cytokine signaling 2
chr6_+_43770202 2.00 ENST00000372067.8
ENST00000672860.2
VEGFA
vascular endothelial growth factor A
chr12_+_93570381 1.90 ENST00000549206.5
SOCS2
suppressor of cytokine signaling 2
chr11_-_64759967 1.74 ENST00000377432.7
ENST00000164139.4
PYGM
glycogen phosphorylase, muscle associated
chr6_+_43770707 1.64 ENST00000324450.11
ENST00000417285.7
ENST00000413642.8
ENST00000372055.9
ENST00000482630.7
ENST00000425836.7
ENST00000372064.9
ENST00000372077.8
ENST00000519767.5
VEGFA
vascular endothelial growth factor A
chr11_-_19202004 1.63 ENST00000648719.1
CSRP3
cysteine and glycine rich protein 3
chr9_-_107489754 1.44 ENST00000610832.1
ENST00000374672.5
KLF4
Kruppel like factor 4
chr16_-_1782526 1.27 ENST00000566339.6
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr3_-_50322759 1.19 ENST00000442581.1
ENST00000447092.5
HYAL2
hyaluronidase 2
chr3_-_50322733 1.19 ENST00000428028.1
ENST00000357750.9
HYAL2
hyaluronidase 2
chr7_-_30550761 1.01 ENST00000598361.4
ENST00000440438.6
ENSG00000281039.1
GARS1-DT
novel protein
GARS1 divergent transcript
chr16_-_11915991 0.98 ENST00000420576.6
GSPT1
G1 to S phase transition 1
chr17_-_49362206 0.95 ENST00000430262.3
ZNF652
zinc finger protein 652
chr16_-_67481131 0.83 ENST00000290949.8
ATP6V0D1
ATPase H+ transporting V0 subunit d1
chr19_+_1269266 0.80 ENST00000585630.5
ENST00000589710.5
ENST00000628979.2
ENST00000586773.5
ENST00000587323.5
ENST00000589686.5
ENST00000588230.5
ENST00000413636.6
ENST00000587896.6
ENST00000320936.9
ENST00000589235.5
ENST00000591659.5
CIRBP
cold inducible RNA binding protein
chr6_-_46954922 0.77 ENST00000265417.7
ADGRF5
adhesion G protein-coupled receptor F5
chr16_-_67481079 0.70 ENST00000565835.5
ENST00000602876.5
ENST00000540149.5
ATP6V0D1
ATPase H+ transporting V0 subunit d1
chr11_-_65662780 0.61 ENST00000534283.1
ENST00000527749.5
ENST00000533187.5
ENST00000525693.5
ENST00000534558.5
ENST00000532879.5
ENST00000406246.8
ENST00000532999.5
RELA
RELA proto-oncogene, NF-kB subunit
chr2_+_159733958 0.61 ENST00000409591.5
MARCHF7
membrane associated ring-CH-type finger 7
chr3_+_185586270 0.60 ENST00000296257.10
SENP2
SUMO specific peptidase 2
chr16_+_1782940 0.58 ENST00000262302.14
ENST00000563136.5
ENST00000565987.5
ENST00000568287.5
ENST00000565134.5
NUBP2
nucleotide binding protein 2
chr12_-_68225806 0.52 ENST00000229134.5
IL26
interleukin 26
chr6_-_136526654 0.51 ENST00000611373.1
MAP7
microtubule associated protein 7
chr11_+_67605488 0.50 ENST00000533876.1
ENST00000647561.1
ENSG00000255119.1
NDUFV1
novel transcript
NADH:ubiquinone oxidoreductase core subunit V1
chr3_-_65597886 0.50 ENST00000460329.6
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr14_+_21317535 0.49 ENST00000382933.8
RPGRIP1
RPGR interacting protein 1
chr7_+_98106852 0.48 ENST00000297293.6
LMTK2
lemur tyrosine kinase 2
chr2_+_118942188 0.46 ENST00000327097.5
MARCO
macrophage receptor with collagenous structure
chr10_+_100535927 0.43 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr10_-_119536533 0.41 ENST00000392865.5
RGS10
regulator of G protein signaling 10
chr8_+_39913881 0.41 ENST00000518237.6
IDO1
indoleamine 2,3-dioxygenase 1
chr20_+_58841343 0.41 ENST00000491348.5
ENST00000472183.6
GNAS
GNAS complex locus
chr2_+_161160420 0.41 ENST00000392749.7
ENST00000405852.5
TANK
TRAF family member associated NFKB activator
chr8_-_94436926 0.40 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr12_-_54258275 0.40 ENST00000552562.1
CBX5
chromobox 5
chr17_-_50707855 0.39 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr5_+_178130996 0.38 ENST00000515098.5
ENST00000502814.5
ENST00000313386.9
ENST00000507457.5
ENST00000508647.5
RMND5B
required for meiotic nuclear division 5 homolog B
chr10_-_104085847 0.32 ENST00000648076.2
COL17A1
collagen type XVII alpha 1 chain
chr10_-_101818425 0.29 ENST00000361464.8
ENST00000439817.5
OGA
O-GlcNAcase
chr1_+_154567770 0.29 ENST00000368476.4
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr1_+_154567820 0.27 ENST00000637900.1
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr1_+_159826860 0.25 ENST00000289707.10
SLAMF8
SLAM family member 8
chr10_-_101818405 0.24 ENST00000357797.9
ENST00000370094.7
OGA
O-GlcNAcase
chr20_+_46894581 0.21 ENST00000357410.7
ENST00000611592.4
EYA2
EYA transcriptional coactivator and phosphatase 2
chr2_-_29921580 0.20 ENST00000389048.8
ALK
ALK receptor tyrosine kinase
chr20_+_58840692 0.20 ENST00000306090.12
GNAS
GNAS complex locus
chr4_+_109827963 0.19 ENST00000317735.7
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr7_-_128775793 0.16 ENST00000249389.3
OPN1SW
opsin 1, short wave sensitive
chr17_-_61863327 0.16 ENST00000584322.2
ENST00000682369.1
ENST00000683039.1
ENST00000683381.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr2_+_161160299 0.15 ENST00000440506.5
ENST00000429217.5
ENST00000406287.5
ENST00000402568.5
TANK
TRAF family member associated NFKB activator
chr5_-_181238195 0.15 ENST00000509148.1
RACK1
receptor for activated C kinase 1
chr13_+_108596152 0.15 ENST00000356711.7
ENST00000251041.10
MYO16
myosin XVI
chr12_+_56021005 0.14 ENST00000547167.6
IKZF4
IKAROS family zinc finger 4
chr12_+_4562192 0.13 ENST00000543431.5
DYRK4
dual specificity tyrosine phosphorylation regulated kinase 4
chr1_+_67166448 0.13 ENST00000347310.10
IL23R
interleukin 23 receptor
chr19_-_42423100 0.12 ENST00000597001.1
LIPE
lipase E, hormone sensitive type
chr1_+_26543106 0.12 ENST00000530003.5
RPS6KA1
ribosomal protein S6 kinase A1
chr12_-_81758665 0.09 ENST00000549325.5
ENST00000550584.6
PPFIA2
PTPRF interacting protein alpha 2
chr1_-_217137748 0.09 ENST00000493603.5
ENST00000366940.6
ESRRG
estrogen related receptor gamma
chr6_-_111605859 0.09 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr3_-_184378136 0.08 ENST00000445696.6
THPO
thrombopoietin
chrX_-_111412162 0.07 ENST00000637570.1
ENST00000356220.8
ENST00000636035.2
ENST00000637453.1
ENST00000635795.1
DCX
doublecortin
chr7_+_102285125 0.05 ENST00000536178.3
SH2B2
SH2B adaptor protein 2
chr18_-_26091175 0.05 ENST00000579061.5
ENST00000542420.6
SS18
SS18 subunit of BAF chromatin remodeling complex
chr3_+_45945019 0.01 ENST00000458629.1
ENST00000457814.1
CXCR6
C-X-C motif chemokine receptor 6
chr3_-_45915698 0.01 ENST00000539217.5
LZTFL1
leucine zipper transcription factor like 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.5 8.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.5 1.4 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.5 2.4 GO:0019087 transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295)
0.3 1.6 GO:0035995 detection of muscle stretch(GO:0035995)
0.3 1.0 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 3.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 0.6 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.2 0.6 GO:0036269 swimming behavior(GO:0036269)
0.1 0.6 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
0.1 0.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.6 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.8 GO:0043129 surfactant homeostasis(GO:0043129)
0.1 0.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 1.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.2 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 1.7 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.6 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051343)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.5 GO:0033572 transferrin transport(GO:0033572)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 2.6 GO:0001837 epithelial to mesenchymal transition(GO:0001837)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0018444 translation release factor complex(GO:0018444)
0.2 0.6 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.1 0.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 2.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.5 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 1.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 3.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 8.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0004556 alpha-amylase activity(GO:0004556)
0.7 3.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.5 4.0 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.5 2.4 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.4 1.7 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.3 1.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 1.4 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.2 1.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 1.6 GO:0031433 telethonin binding(GO:0031433)
0.1 1.0 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.4 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 2.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 0.6 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 8.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.5 GO:0010181 FMN binding(GO:0010181)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 3.9 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 3.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 3.9 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen