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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RUNX3_BCL11A
Z-value: 0.40
Motif logo
Transcription factors associated with RUNX3_BCL11A
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RUNX3
|
ENSG00000020633.19 | RUNX3 |
|
BCL11A
|
ENSG00000119866.22 | BCL11A |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX3 | hg38_v1_chr1_-_24964984_24965020 | 0.71 | 3.2e-35 | Click! |
| BCL11A | hg38_v1_chr2_-_60553618_60553664 | 0.14 | 3.3e-02 | Click! |
Activity profile of RUNX3_BCL11A motif
Sorted Z-values of RUNX3_BCL11A motif
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX3_BCL11A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 21.9 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 6.9 | 20.8 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 6.9 | 20.6 | GO:0002625 | regulation of T cell antigen processing and presentation(GO:0002625) |
| 5.9 | 17.8 | GO:0036292 | DNA rewinding(GO:0036292) |
| 5.9 | 17.6 | GO:1901624 | negative regulation of lymphocyte chemotaxis(GO:1901624) |
| 5.5 | 16.6 | GO:2000537 | regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 5.0 | 20.0 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
| 4.8 | 38.2 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 4.8 | 14.3 | GO:0002304 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 4.7 | 18.8 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 4.2 | 25.2 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 4.1 | 20.3 | GO:1902523 | negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523) |
| 3.6 | 28.6 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 3.4 | 27.4 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 3.3 | 16.4 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 3.1 | 24.7 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 3.0 | 9.1 | GO:1902948 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 3.0 | 8.9 | GO:1904845 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 2.9 | 14.6 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 2.8 | 14.1 | GO:2000503 | regulation of natural killer cell chemotaxis(GO:2000501) positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 2.5 | 27.6 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 2.5 | 14.7 | GO:0048619 | embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619) |
| 2.4 | 53.3 | GO:0097320 | membrane tubulation(GO:0097320) |
| 2.4 | 31.4 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 2.4 | 7.2 | GO:1904882 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
| 2.1 | 25.2 | GO:0001865 | NK T cell differentiation(GO:0001865) |
| 2.0 | 36.5 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 2.0 | 6.0 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 1.9 | 7.5 | GO:0002370 | natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) |
| 1.7 | 13.5 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996) |
| 1.6 | 6.3 | GO:0060335 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 1.6 | 6.2 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 1.5 | 7.7 | GO:1903936 | cellular response to sodium arsenite(GO:1903936) |
| 1.5 | 19.7 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 1.4 | 4.3 | GO:0060437 | lung growth(GO:0060437) |
| 1.4 | 26.5 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 1.2 | 3.7 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 1.2 | 15.9 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 1.1 | 15.2 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 1.0 | 3.0 | GO:0060448 | dichotomous subdivision of terminal units involved in lung branching(GO:0060448) |
| 1.0 | 3.0 | GO:1901860 | positive regulation of mitochondrial DNA metabolic process(GO:1901860) |
| 1.0 | 2.9 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487) |
| 1.0 | 2.9 | GO:1904772 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.9 | 18.4 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.9 | 3.6 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823) |
| 0.9 | 6.2 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.9 | 5.3 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.8 | 2.5 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.8 | 5.1 | GO:0051549 | positive regulation of keratinocyte migration(GO:0051549) |
| 0.7 | 2.2 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.7 | 3.7 | GO:0043144 | snoRNA processing(GO:0043144) |
| 0.7 | 4.4 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.7 | 16.9 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.7 | 12.6 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.7 | 2.8 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.7 | 2.1 | GO:0038178 | complement component C5a signaling pathway(GO:0038178) |
| 0.7 | 2.0 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.7 | 8.7 | GO:1901072 | glucosamine-containing compound catabolic process(GO:1901072) |
| 0.7 | 8.6 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
| 0.7 | 6.6 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.6 | 7.8 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.6 | 3.9 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.6 | 5.0 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.6 | 3.1 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.6 | 3.4 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.5 | 4.3 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 0.5 | 2.1 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.5 | 6.4 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.5 | 2.1 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.5 | 12.7 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.5 | 2.0 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 0.5 | 5.8 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.5 | 7.9 | GO:0002335 | mature B cell differentiation(GO:0002335) |
| 0.4 | 18.5 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.4 | 1.2 | GO:0098507 | polynucleotide 5' dephosphorylation(GO:0098507) |
| 0.4 | 4.1 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
| 0.4 | 9.4 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.4 | 5.3 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.4 | 2.7 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.4 | 4.6 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.4 | 1.5 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.4 | 3.3 | GO:0048298 | regulation of isotype switching to IgA isotypes(GO:0048296) positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.4 | 29.4 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.4 | 2.8 | GO:0003402 | planar cell polarity pathway involved in axis elongation(GO:0003402) |
| 0.3 | 30.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.3 | 4.0 | GO:0043587 | tongue morphogenesis(GO:0043587) |
| 0.3 | 5.5 | GO:0034447 | very-low-density lipoprotein particle clearance(GO:0034447) |
| 0.3 | 0.6 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.3 | 1.5 | GO:0016199 | axon midline choice point recognition(GO:0016199) |
| 0.3 | 4.0 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.3 | 1.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.3 | 3.3 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.3 | 54.0 | GO:0050680 | negative regulation of epithelial cell proliferation(GO:0050680) |
| 0.3 | 4.1 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.3 | 25.8 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.3 | 0.8 | GO:0021658 | rhombomere 5 development(GO:0021571) rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.3 | 23.1 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.3 | 0.8 | GO:0036414 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.3 | 39.1 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.3 | 1.3 | GO:0031291 | Ran protein signal transduction(GO:0031291) |
| 0.3 | 23.2 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.2 | 5.1 | GO:0090656 | t-circle formation(GO:0090656) |
| 0.2 | 0.5 | GO:0002329 | pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331) |
| 0.2 | 1.4 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.2 | 2.1 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
| 0.2 | 1.9 | GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.2 | 1.5 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 1.1 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.2 | 4.4 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.2 | 6.5 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.2 | 8.1 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.2 | 0.8 | GO:0080154 | regulation of fertilization(GO:0080154) |
| 0.2 | 1.1 | GO:0090154 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.2 | 1.3 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.2 | 5.9 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.2 | 10.9 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.2 | 6.8 | GO:0016445 | somatic diversification of immunoglobulins(GO:0016445) |
| 0.2 | 0.7 | GO:2000504 | positive regulation of blood vessel remodeling(GO:2000504) |
| 0.2 | 2.3 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.2 | 3.1 | GO:1900363 | regulation of mRNA polyadenylation(GO:1900363) |
| 0.2 | 0.6 | GO:0030806 | negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821) |
| 0.1 | 3.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 3.3 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.1 | 0.4 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.1 | 4.1 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 1.2 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.1 | 9.8 | GO:0070301 | cellular response to hydrogen peroxide(GO:0070301) |
| 0.1 | 0.3 | GO:2000017 | positive regulation of determination of dorsal identity(GO:2000017) |
| 0.1 | 1.6 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.1 | 0.9 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.1 | 1.8 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.1 | 1.3 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.1 | 1.0 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 0.1 | 0.5 | GO:0008215 | spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295) |
| 0.1 | 0.7 | GO:0070857 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) regulation of bile acid biosynthetic process(GO:0070857) |
| 0.1 | 11.8 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 2.4 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.1 | 10.8 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.1 | 0.4 | GO:0071104 | response to interleukin-9(GO:0071104) |
| 0.1 | 1.3 | GO:1901663 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 2.8 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 4.8 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.1 | 0.5 | GO:0003096 | renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294) |
| 0.1 | 1.5 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.1 | 0.2 | GO:0018160 | peptidyl-pyrromethane cofactor linkage(GO:0018160) |
| 0.1 | 0.2 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.1 | 9.2 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.1 | 3.2 | GO:0034113 | heterotypic cell-cell adhesion(GO:0034113) |
| 0.1 | 1.4 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 2.3 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.1 | 3.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 0.9 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 1.3 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.0 | 3.6 | GO:0032481 | positive regulation of type I interferon production(GO:0032481) |
| 0.0 | 0.7 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 1.9 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.0 | 0.9 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 2.0 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 2.6 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 1.5 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 3.3 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.9 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.7 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.0 | 0.3 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.0 | 0.1 | GO:2001140 | regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140) |
| 0.0 | 0.7 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724) |
| 0.0 | 0.4 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.0 | 0.6 | GO:0061001 | regulation of dendritic spine morphogenesis(GO:0061001) |
| 0.0 | 11.5 | GO:0006396 | RNA processing(GO:0006396) |
| 0.0 | 1.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.2 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.0 | 5.1 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 20.0 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 3.6 | 92.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 2.9 | 31.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.9 | 24.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 1.3 | 5.3 | GO:0044307 | dendritic branch(GO:0044307) |
| 1.3 | 86.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 1.1 | 14.6 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 1.0 | 17.1 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.9 | 9.4 | GO:0032039 | integrator complex(GO:0032039) |
| 0.9 | 2.6 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.8 | 2.5 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.8 | 4.1 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.8 | 19.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.8 | 38.2 | GO:0002102 | podosome(GO:0002102) |
| 0.6 | 8.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.6 | 27.8 | GO:0008305 | integrin complex(GO:0008305) |
| 0.6 | 8.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.5 | 14.7 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.5 | 6.9 | GO:0070938 | contractile ring(GO:0070938) |
| 0.5 | 10.1 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.4 | 6.2 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.4 | 4.1 | GO:0044754 | autolysosome(GO:0044754) |
| 0.4 | 56.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.4 | 3.0 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.4 | 10.4 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.3 | 5.1 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.3 | 6.8 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.3 | 2.2 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.3 | 2.8 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.3 | 22.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.2 | 47.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 2.8 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 31.1 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 2.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 4.8 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.2 | 8.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 3.2 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.2 | 3.7 | GO:0005684 | U2-type spliceosomal complex(GO:0005684) |
| 0.2 | 2.9 | GO:0045120 | pronucleus(GO:0045120) |
| 0.2 | 4.0 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.2 | 54.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 22.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 2.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.2 | 24.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.2 | 3.6 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 4.1 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.1 | 0.9 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.1 | 1.1 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.1 | 2.0 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 7.2 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 35.4 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 9.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 6.8 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 5.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 1.5 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 3.3 | GO:0016514 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.1 | 1.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 10.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 24.3 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 1.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 8.8 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.3 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.1 | 1.5 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.8 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 0.7 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.1 | 6.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 5.1 | GO:0005798 | Golgi-associated vesicle(GO:0005798) |
| 0.1 | 9.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 14.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 4.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 0.3 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 1.5 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 2.4 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 2.7 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 4.4 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 2.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.7 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 3.3 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.0 | 1.6 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 4.8 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.7 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 0.9 | GO:0005903 | brush border(GO:0005903) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 17.8 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 3.5 | 14.1 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 3.2 | 15.9 | GO:1990254 | keratin filament binding(GO:1990254) |
| 3.2 | 28.6 | GO:0043426 | MRF binding(GO:0043426) |
| 3.1 | 15.3 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 2.6 | 20.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 2.6 | 7.7 | GO:0061752 | telomeric repeat-containing RNA binding(GO:0061752) |
| 2.3 | 16.1 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 1.8 | 5.4 | GO:0004939 | beta-adrenergic receptor activity(GO:0004939) |
| 1.6 | 12.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.4 | 7.2 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 1.4 | 26.5 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 1.3 | 27.0 | GO:0005522 | profilin binding(GO:0005522) |
| 1.2 | 3.7 | GO:0033300 | dehydroascorbic acid transporter activity(GO:0033300) |
| 1.2 | 3.6 | GO:0015265 | urea channel activity(GO:0015265) |
| 1.2 | 18.1 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 1.2 | 16.4 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 1.1 | 4.6 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 1.1 | 6.6 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 1.0 | 25.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.9 | 2.8 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.9 | 19.7 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.9 | 2.6 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.8 | 31.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.8 | 8.0 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.8 | 20.6 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.7 | 2.2 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.7 | 15.4 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.7 | 25.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.7 | 17.6 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.7 | 61.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.7 | 2.1 | GO:0004878 | complement component C5a receptor activity(GO:0004878) |
| 0.7 | 5.5 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.6 | 6.7 | GO:0004568 | chitinase activity(GO:0004568) chitin binding(GO:0008061) |
| 0.6 | 19.0 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.6 | 9.1 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.5 | 3.1 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.5 | 8.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.5 | 6.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.5 | 2.9 | GO:0016807 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.5 | 1.4 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.5 | 4.1 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.4 | 8.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.4 | 2.5 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.4 | 1.2 | GO:0004651 | polynucleotide 5'-phosphatase activity(GO:0004651) |
| 0.4 | 1.9 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.4 | 2.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 5.0 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.3 | 4.0 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.3 | 3.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.3 | 37.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.3 | 2.1 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.2 | 11.2 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.2 | 1.5 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.2 | 2.9 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 2.1 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.2 | 2.9 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.2 | 5.3 | GO:0051959 | protein kinase B binding(GO:0043422) dynein light intermediate chain binding(GO:0051959) |
| 0.2 | 32.4 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.2 | 1.9 | GO:0030884 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.2 | 25.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.2 | 2.9 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.2 | 0.8 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.2 | 2.0 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.2 | 0.7 | GO:0001588 | dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) |
| 0.2 | 3.0 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.2 | 50.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 6.5 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.2 | 1.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.2 | 3.6 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.2 | 1.4 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.2 | 25.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.2 | 5.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.2 | 7.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 1.7 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.2 | 2.3 | GO:0001222 | transcription corepressor binding(GO:0001222) protein tag(GO:0031386) |
| 0.2 | 3.3 | GO:0070008 | serine-type carboxypeptidase activity(GO:0004185) serine-type exopeptidase activity(GO:0070008) |
| 0.2 | 3.1 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.1 | 4.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 6.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 3.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 17.0 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 0.4 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.1 | 1.1 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 0.9 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 1.3 | GO:0003720 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.1 | 2.7 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.8 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 3.1 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 1.6 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 8.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 0.3 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.1 | 2.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 13.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 2.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 4.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 1.1 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 0.7 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 1.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.6 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.1 | 2.1 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.1 | 3.3 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 26.4 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.1 | 0.2 | GO:0004418 | hydroxymethylbilane synthase activity(GO:0004418) |
| 0.1 | 3.2 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 10.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 0.3 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.0 | 2.0 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 14.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 12.7 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 2.8 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.5 | GO:0070405 | ammonium ion binding(GO:0070405) |
| 0.0 | 2.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.4 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 2.8 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.8 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 0.1 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.0 | 12.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 15.2 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 2.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 3.8 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 0.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 16.5 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
| 0.0 | 0.1 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.0 | 2.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.5 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 103.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.9 | 82.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.7 | 20.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.5 | 27.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.4 | 8.0 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.4 | 38.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 24.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.4 | 14.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.3 | 23.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.3 | 9.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.3 | 11.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.3 | 7.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.3 | 8.8 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 29.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.2 | 3.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 4.4 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.2 | 3.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 2.7 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 1.3 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 7.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 7.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 10.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 5.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 12.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 10.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 33.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 1.7 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 13.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 2.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 2.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 2.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 2.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.7 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 0.6 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 21.9 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 1.6 | 75.8 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 1.4 | 32.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 1.3 | 26.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 1.0 | 25.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.8 | 27.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.8 | 9.9 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.7 | 60.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.7 | 43.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 15.9 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 19.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.5 | 5.8 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.5 | 8.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.5 | 24.7 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.4 | 6.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.3 | 3.6 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.3 | 8.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 8.0 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.3 | 14.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.3 | 3.6 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.3 | 13.3 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.2 | 4.7 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.2 | 2.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 8.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 2.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.2 | 21.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 3.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 3.3 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.2 | 5.3 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.2 | 4.6 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.2 | 3.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 2.8 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 9.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 38.7 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.1 | 5.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 4.4 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.3 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 16.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.8 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 3.3 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.1 | 1.2 | REACTOME MRNA CAPPING | Genes involved in mRNA Capping |
| 0.1 | 1.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 10.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.1 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 3.1 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 2.1 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.6 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.0 | 1.0 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.6 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 1.3 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.6 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.0 | 0.6 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 1.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.9 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |