Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SHOX2_HOXC5
Z-value: 7.71
Motif logo
Transcription factors associated with SHOX2_HOXC5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SHOX2
|
ENSG00000168779.20 | SHOX2 |
|
HOXC5
|
ENSG00000172789.4 | HOXC5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SHOX2 | hg38_v1_chr3_-_158105718_158105773 | -0.50 | 5.1e-15 | Click! |
| HOXC5 | hg38_v1_chr12_+_54033026_54033069 | -0.18 | 7.9e-03 | Click! |
Activity profile of SHOX2_HOXC5 motif
Sorted Z-values of SHOX2_HOXC5 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of SHOX2_HOXC5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 35.2 | 105.7 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 18.2 | 91.0 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 16.7 | 66.9 | GO:0051257 | meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311) |
| 14.7 | 58.8 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 11.2 | 78.5 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 9.4 | 28.1 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 9.0 | 26.9 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 7.6 | 37.9 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 6.4 | 19.3 | GO:0090149 | mitochondrial membrane fission(GO:0090149) |
| 6.3 | 25.4 | GO:0002188 | translation reinitiation(GO:0002188) |
| 6.2 | 18.6 | GO:0060623 | regulation of chromosome condensation(GO:0060623) cellular response to iron(III) ion(GO:0071283) |
| 6.0 | 78.3 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 5.8 | 80.6 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 5.7 | 17.0 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 5.5 | 16.6 | GO:1903926 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 5.3 | 42.3 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 4.8 | 29.1 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 4.8 | 19.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 4.6 | 13.9 | GO:0034183 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 4.5 | 18.0 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
| 4.4 | 21.9 | GO:0070370 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 4.4 | 13.1 | GO:0044752 | response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387) |
| 4.2 | 12.7 | GO:0061011 | hepatic duct development(GO:0061011) |
| 3.9 | 54.2 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 3.8 | 11.5 | GO:0097698 | telomere maintenance via base-excision repair(GO:0097698) |
| 3.8 | 15.0 | GO:0006238 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 3.7 | 18.4 | GO:0070425 | negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) |
| 3.7 | 14.6 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 3.7 | 21.9 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563) |
| 3.5 | 41.8 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 3.4 | 13.6 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 3.3 | 6.6 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 3.3 | 9.9 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 3.2 | 13.0 | GO:2000434 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 3.2 | 9.7 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 3.2 | 29.1 | GO:1904798 | positive regulation of core promoter binding(GO:1904798) |
| 3.2 | 9.7 | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
| 3.2 | 9.7 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 3.1 | 18.7 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 3.0 | 15.0 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 3.0 | 11.8 | GO:0000961 | negative regulation of mitochondrial RNA catabolic process(GO:0000961) |
| 3.0 | 8.9 | GO:0001923 | B-1 B cell differentiation(GO:0001923) |
| 2.8 | 8.5 | GO:1903674 | regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676) |
| 2.8 | 8.4 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 2.6 | 10.4 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 2.5 | 22.7 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 2.5 | 12.6 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 2.5 | 15.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 2.5 | 46.9 | GO:0003334 | keratinocyte development(GO:0003334) |
| 2.4 | 7.1 | GO:1901253 | negative regulation of intracellular transport of viral material(GO:1901253) |
| 2.4 | 11.9 | GO:2000542 | negative regulation of gastrulation(GO:2000542) |
| 2.4 | 7.1 | GO:0016488 | sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224) |
| 2.2 | 11.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 2.2 | 6.7 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 2.2 | 11.1 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 2.2 | 26.3 | GO:0045116 | protein neddylation(GO:0045116) |
| 2.1 | 23.6 | GO:0042262 | DNA protection(GO:0042262) |
| 2.1 | 15.0 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 2.1 | 6.4 | GO:0036245 | cellular response to menadione(GO:0036245) |
| 2.1 | 6.3 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 2.1 | 12.4 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 2.1 | 26.8 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 2.1 | 12.4 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 2.1 | 6.2 | GO:0002503 | peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 2.0 | 16.2 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 2.0 | 8.1 | GO:1904823 | pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 2.0 | 10.0 | GO:0003070 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 2.0 | 11.8 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 2.0 | 25.5 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 1.9 | 25.1 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 1.9 | 15.1 | GO:0051026 | chiasma assembly(GO:0051026) |
| 1.9 | 88.4 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 1.9 | 7.5 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 1.8 | 16.6 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 1.8 | 5.5 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 1.8 | 16.2 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 1.8 | 23.0 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 1.7 | 7.0 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 1.7 | 5.2 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 1.7 | 3.4 | GO:0003162 | atrioventricular node development(GO:0003162) |
| 1.6 | 4.9 | GO:0002305 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 1.6 | 6.4 | GO:0036116 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 1.6 | 8.0 | GO:0006574 | valine catabolic process(GO:0006574) |
| 1.5 | 9.1 | GO:0000710 | meiotic mismatch repair(GO:0000710) |
| 1.5 | 60.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 1.5 | 7.4 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 1.5 | 11.8 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 1.4 | 18.7 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 1.4 | 5.7 | GO:0061668 | mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 1.4 | 8.4 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 1.4 | 4.2 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 1.4 | 2.8 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 1.3 | 12.1 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 1.3 | 11.9 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 1.3 | 6.3 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 1.3 | 8.8 | GO:0015866 | ADP transport(GO:0015866) |
| 1.3 | 82.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.2 | 115.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 1.2 | 3.7 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 1.2 | 6.0 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 1.2 | 2.4 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 1.2 | 20.0 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 1.2 | 7.1 | GO:1903435 | regulation of constitutive secretory pathway(GO:1903433) positive regulation of constitutive secretory pathway(GO:1903435) |
| 1.2 | 2.3 | GO:0031393 | negative regulation of prostaglandin biosynthetic process(GO:0031393) |
| 1.2 | 17.6 | GO:0070986 | left/right axis specification(GO:0070986) |
| 1.2 | 7.0 | GO:1900368 | regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) |
| 1.2 | 12.7 | GO:0051451 | myoblast migration(GO:0051451) |
| 1.1 | 14.8 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 1.1 | 7.9 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 1.1 | 4.5 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 1.1 | 3.3 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 1.1 | 15.5 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 1.1 | 13.2 | GO:2000279 | negative regulation of DNA biosynthetic process(GO:2000279) |
| 1.1 | 8.8 | GO:0030091 | protein repair(GO:0030091) |
| 1.1 | 11.9 | GO:0042407 | cristae formation(GO:0042407) |
| 1.1 | 8.5 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 1.1 | 6.3 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 1.0 | 3.1 | GO:0031448 | regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) |
| 1.0 | 8.1 | GO:0009597 | detection of virus(GO:0009597) |
| 1.0 | 13.2 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 1.0 | 6.0 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 1.0 | 13.9 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 1.0 | 2.9 | GO:0010710 | regulation of collagen catabolic process(GO:0010710) |
| 1.0 | 8.8 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 1.0 | 5.7 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) |
| 1.0 | 5.7 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 1.0 | 21.0 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.9 | 8.5 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.9 | 6.6 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.9 | 25.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.9 | 7.4 | GO:2001205 | TNFSF11-mediated signaling pathway(GO:0071847) negative regulation of osteoclast development(GO:2001205) |
| 0.9 | 19.1 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.9 | 13.5 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.9 | 7.2 | GO:0046146 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.9 | 4.5 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.9 | 9.8 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.9 | 5.3 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.9 | 1.8 | GO:0001812 | regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068) |
| 0.9 | 6.2 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.9 | 12.4 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.9 | 6.0 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.9 | 74.4 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 0.9 | 6.8 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.8 | 0.8 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
| 0.8 | 8.2 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.8 | 5.7 | GO:1903551 | regulation of extracellular exosome assembly(GO:1903551) |
| 0.8 | 6.5 | GO:0002759 | regulation of antimicrobial humoral response(GO:0002759) |
| 0.8 | 13.7 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.8 | 2.4 | GO:1901355 | response to rapamycin(GO:1901355) |
| 0.8 | 8.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.8 | 2.4 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.8 | 4.8 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.8 | 7.2 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.8 | 32.7 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.8 | 3.1 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.8 | 11.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.8 | 7.0 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.8 | 4.6 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.8 | 99.4 | GO:0006414 | translational elongation(GO:0006414) |
| 0.8 | 11.3 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.7 | 10.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.7 | 1.5 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.7 | 112.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.7 | 6.4 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.7 | 53.1 | GO:0048208 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.7 | 21.7 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 0.7 | 10.4 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.7 | 2.7 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.7 | 6.8 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.7 | 17.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.7 | 2.0 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.6 | 5.2 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.6 | 12.3 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
| 0.6 | 1.3 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 0.6 | 15.6 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.6 | 2.5 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.6 | 13.6 | GO:0097341 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 0.6 | 12.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.6 | 4.3 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.6 | 14.7 | GO:0055070 | copper ion homeostasis(GO:0055070) |
| 0.6 | 6.1 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
| 0.6 | 27.2 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.6 | 8.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.6 | 8.4 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.6 | 4.2 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.6 | 3.6 | GO:0010616 | negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of lung blood pressure(GO:0061767) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243) |
| 0.6 | 4.1 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.6 | 7.6 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
| 0.6 | 9.4 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.6 | 1.7 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.6 | 5.7 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.6 | 4.5 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.6 | 1.1 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.6 | 2.2 | GO:0039516 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 0.6 | 2.2 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.5 | 5.5 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.5 | 4.8 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.5 | 6.4 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.5 | 2.1 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.5 | 46.2 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.5 | 20.9 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.5 | 5.2 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.5 | 6.0 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.5 | 35.0 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 0.5 | 18.9 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.5 | 2.0 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.5 | 35.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.5 | 1.5 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.5 | 4.9 | GO:0032071 | regulation of endodeoxyribonuclease activity(GO:0032071) |
| 0.5 | 2.0 | GO:0061643 | chemorepulsion of dopaminergic neuron axon(GO:0036518) chemorepulsion of axon(GO:0061643) |
| 0.5 | 2.0 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
| 0.5 | 3.4 | GO:2000229 | pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.5 | 10.7 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.5 | 73.6 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.5 | 2.4 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.5 | 8.1 | GO:0097502 | mannosylation(GO:0097502) |
| 0.5 | 3.3 | GO:1903543 | positive regulation of exosomal secretion(GO:1903543) |
| 0.5 | 18.7 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.5 | 6.9 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.5 | 3.2 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.4 | 2.2 | GO:0006668 | sphinganine-1-phosphate metabolic process(GO:0006668) |
| 0.4 | 3.1 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.4 | 10.4 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.4 | 6.5 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.4 | 12.1 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.4 | 2.1 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.4 | 15.4 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.4 | 1.6 | GO:0032808 | lacrimal gland development(GO:0032808) |
| 0.4 | 14.7 | GO:1901998 | toxin transport(GO:1901998) |
| 0.4 | 6.5 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.4 | 3.6 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.4 | 1.2 | GO:0036493 | positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) |
| 0.4 | 4.4 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.4 | 3.9 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.4 | 2.3 | GO:0090343 | positive regulation of cell aging(GO:0090343) |
| 0.4 | 13.5 | GO:0009251 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.4 | 24.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.4 | 17.4 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.4 | 6.5 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.4 | 4.1 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.4 | 2.2 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.3 | 11.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.3 | 0.3 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.3 | 4.8 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.3 | 1.0 | GO:0071877 | regulation of adrenergic receptor signaling pathway(GO:0071877) |
| 0.3 | 19.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.3 | 9.7 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.3 | 1.6 | GO:0046449 | creatinine metabolic process(GO:0046449) |
| 0.3 | 0.6 | GO:1990637 | response to prolactin(GO:1990637) |
| 0.3 | 3.5 | GO:0044829 | modulation by host of viral genome replication(GO:0044827) positive regulation by host of viral genome replication(GO:0044829) |
| 0.3 | 2.5 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.3 | 1.2 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 0.3 | 5.2 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.3 | 13.7 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.3 | 1.2 | GO:0010585 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 0.3 | 12.9 | GO:0034644 | cellular response to UV(GO:0034644) |
| 0.3 | 4.0 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) |
| 0.3 | 17.6 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.3 | 2.8 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.3 | 8.4 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.3 | 14.9 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
| 0.3 | 2.4 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
| 0.3 | 0.8 | GO:0003099 | positive regulation of the force of heart contraction by chemical signal(GO:0003099) |
| 0.3 | 0.8 | GO:0048840 | otolith development(GO:0048840) |
| 0.3 | 12.1 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.3 | 5.9 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.3 | 6.1 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.3 | 0.5 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.3 | 5.9 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 0.3 | 1.3 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.3 | 9.0 | GO:0014904 | myotube cell development(GO:0014904) |
| 0.2 | 0.7 | GO:0031550 | positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550) |
| 0.2 | 5.6 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.2 | 1.2 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.2 | 13.1 | GO:0000070 | mitotic sister chromatid segregation(GO:0000070) |
| 0.2 | 5.4 | GO:0071732 | cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170) |
| 0.2 | 1.4 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 3.4 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.2 | 10.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.2 | 5.8 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.2 | 6.0 | GO:0039694 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.2 | 0.7 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) regulation of toll-like receptor 9 signaling pathway(GO:0034163) |
| 0.2 | 1.7 | GO:0072656 | maintenance of protein location in mitochondrion(GO:0072656) |
| 0.2 | 3.0 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.2 | 1.3 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.2 | 5.3 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process(GO:0015012) |
| 0.2 | 4.9 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.2 | 2.3 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.2 | 2.5 | GO:0009642 | response to light intensity(GO:0009642) |
| 0.2 | 4.0 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.2 | 24.0 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.2 | 5.0 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.2 | 0.6 | GO:0060352 | cell adhesion molecule production(GO:0060352) |
| 0.2 | 0.8 | GO:0042421 | norepinephrine biosynthetic process(GO:0042421) |
| 0.2 | 1.5 | GO:1902358 | sulfate transmembrane transport(GO:1902358) |
| 0.2 | 1.5 | GO:1901475 | pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475) |
| 0.2 | 8.4 | GO:0018279 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.2 | 2.6 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.2 | 8.1 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.2 | 2.0 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) arterial endothelial cell differentiation(GO:0060842) |
| 0.2 | 1.2 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.2 | 1.8 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.2 | 0.8 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.2 | 3.1 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.2 | 0.6 | GO:0030070 | insulin processing(GO:0030070) |
| 0.2 | 13.5 | GO:0006413 | translational initiation(GO:0006413) |
| 0.2 | 4.8 | GO:0035904 | aorta development(GO:0035904) |
| 0.2 | 0.9 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.2 | 3.4 | GO:0050869 | negative regulation of B cell activation(GO:0050869) |
| 0.2 | 2.3 | GO:0055026 | negative regulation of cardiac muscle tissue development(GO:0055026) |
| 0.2 | 3.6 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.2 | 1.8 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.2 | 1.2 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
| 0.1 | 2.2 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 2.4 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
| 0.1 | 4.3 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.1 | 15.5 | GO:0050851 | antigen receptor-mediated signaling pathway(GO:0050851) |
| 0.1 | 7.1 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.1 | 3.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 11.6 | GO:0019079 | viral genome replication(GO:0019079) |
| 0.1 | 2.0 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.1 | 0.1 | GO:1904058 | positive regulation of sensory perception of pain(GO:1904058) |
| 0.1 | 0.6 | GO:0043126 | regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128) |
| 0.1 | 4.0 | GO:0061512 | protein localization to cilium(GO:0061512) |
| 0.1 | 4.7 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.1 | 3.8 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 0.5 | GO:0061358 | negative regulation of Wnt protein secretion(GO:0061358) |
| 0.1 | 4.9 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
| 0.1 | 9.8 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.1 | 6.3 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 66.5 | GO:0006396 | RNA processing(GO:0006396) |
| 0.1 | 1.9 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.1 | 0.2 | GO:0019249 | lactate biosynthetic process(GO:0019249) |
| 0.1 | 4.7 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.1 | 4.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 1.1 | GO:0051005 | plasma membrane to endosome transport(GO:0048227) negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.1 | 14.6 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 0.1 | 1.7 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.1 | 1.1 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.1 | 1.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.5 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.1 | 7.6 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.1 | 0.6 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.1 | 1.7 | GO:2000404 | regulation of T cell migration(GO:2000404) |
| 0.1 | 2.8 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.1 | 1.9 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
| 0.1 | 2.1 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 0.6 | GO:0097283 | keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) |
| 0.1 | 5.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 2.9 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.1 | 1.0 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964) |
| 0.1 | 0.9 | GO:1900037 | regulation of cellular response to hypoxia(GO:1900037) |
| 0.1 | 0.6 | GO:1990592 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.1 | 0.7 | GO:0030007 | cellular potassium ion homeostasis(GO:0030007) response to carbon monoxide(GO:0034465) |
| 0.1 | 0.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 7.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 0.3 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 0.1 | 1.4 | GO:0010659 | cardiac muscle cell apoptotic process(GO:0010659) |
| 0.1 | 1.0 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.1 | 26.5 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.1 | 0.2 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.1 | 2.5 | GO:0051180 | vitamin transport(GO:0051180) |
| 0.1 | 1.0 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.0 | 0.5 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.0 | 0.6 | GO:0034391 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.0 | 0.3 | GO:0051923 | sulfation(GO:0051923) |
| 0.0 | 0.3 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 2.7 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
| 0.0 | 0.6 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.5 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.2 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) |
| 0.0 | 2.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.3 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 1.0 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.0 | 0.7 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 2.6 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 2.1 | GO:0042752 | regulation of circadian rhythm(GO:0042752) |
| 0.0 | 0.5 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
| 0.0 | 2.3 | GO:0006637 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 0.0 | 0.2 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.3 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
| 0.0 | 0.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.0 | 0.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 0.2 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.7 | 66.9 | GO:0005715 | late recombination nodule(GO:0005715) |
| 13.0 | 91.0 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 11.9 | 59.3 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 11.7 | 105.7 | GO:0036449 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 11.2 | 78.5 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 8.4 | 33.6 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 8.1 | 24.2 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
| 7.9 | 94.7 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 7.3 | 29.0 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 7.1 | 78.3 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 7.0 | 21.0 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 6.5 | 58.8 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 6.0 | 6.0 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 5.3 | 21.0 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 4.7 | 18.6 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 4.6 | 13.9 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 4.6 | 13.9 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 4.5 | 13.6 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 4.4 | 13.1 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 4.2 | 54.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 4.1 | 16.2 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 4.0 | 43.7 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 4.0 | 11.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 3.8 | 26.9 | GO:0072589 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 3.7 | 18.4 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 3.7 | 33.1 | GO:0070652 | HAUS complex(GO:0070652) |
| 3.4 | 37.9 | GO:0030870 | Mre11 complex(GO:0030870) |
| 3.3 | 13.2 | GO:0071920 | cleavage body(GO:0071920) |
| 3.3 | 9.8 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 3.2 | 31.8 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 3.1 | 12.6 | GO:0035363 | histone locus body(GO:0035363) |
| 3.0 | 17.7 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 2.8 | 22.7 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 2.6 | 25.8 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 2.6 | 15.5 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 2.4 | 21.8 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 2.4 | 7.2 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 2.3 | 27.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 2.2 | 13.4 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 2.2 | 20.0 | GO:0000346 | transcription export complex(GO:0000346) |
| 2.2 | 17.3 | GO:0000243 | commitment complex(GO:0000243) |
| 2.1 | 10.4 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 2.0 | 11.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 1.9 | 13.2 | GO:0016272 | prefoldin complex(GO:0016272) |
| 1.8 | 53.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 1.8 | 7.2 | GO:0071986 | Ragulator complex(GO:0071986) |
| 1.8 | 16.2 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 1.8 | 8.9 | GO:0032449 | CBM complex(GO:0032449) |
| 1.7 | 7.0 | GO:0044307 | dendritic branch(GO:0044307) |
| 1.7 | 85.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 1.6 | 6.6 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 1.5 | 17.0 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 1.5 | 5.9 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
| 1.5 | 5.8 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 1.4 | 40.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 1.4 | 15.5 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 1.4 | 23.9 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 1.4 | 8.4 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 1.4 | 5.5 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 1.4 | 16.4 | GO:0071203 | WASH complex(GO:0071203) |
| 1.3 | 20.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 1.3 | 6.7 | GO:0031523 | Myb complex(GO:0031523) |
| 1.3 | 6.3 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 1.2 | 14.4 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 1.1 | 5.7 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 1.1 | 11.4 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 1.1 | 9.1 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522) |
| 1.1 | 4.5 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
| 1.1 | 5.5 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 1.1 | 11.9 | GO:0034709 | methylosome(GO:0034709) |
| 1.0 | 9.3 | GO:0042382 | paraspeckles(GO:0042382) |
| 1.0 | 7.0 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 1.0 | 2.9 | GO:0034677 | integrin alpha7-beta1 complex(GO:0034677) |
| 1.0 | 4.8 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 1.0 | 21.9 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.9 | 19.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.9 | 46.9 | GO:0002102 | podosome(GO:0002102) |
| 0.9 | 8.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.9 | 6.1 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.8 | 11.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.8 | 59.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.8 | 7.4 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.8 | 18.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.8 | 11.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.8 | 4.6 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.8 | 40.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.7 | 3.6 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.7 | 6.4 | GO:0045120 | pronucleus(GO:0045120) |
| 0.7 | 4.8 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.7 | 4.7 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.6 | 12.5 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.6 | 2.5 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.6 | 8.0 | GO:0042555 | MCM complex(GO:0042555) |
| 0.6 | 56.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.6 | 6.0 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.6 | 9.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.6 | 22.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.6 | 5.2 | GO:0030990 | intraciliary transport particle(GO:0030990) |
| 0.6 | 12.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.6 | 7.4 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.6 | 8.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.6 | 15.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.6 | 20.7 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.5 | 1.6 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.5 | 11.2 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.5 | 4.1 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.5 | 3.0 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.5 | 8.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.5 | 1.5 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.5 | 2.4 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.5 | 2.3 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.5 | 14.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.5 | 8.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.5 | 47.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 8.9 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.4 | 8.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.4 | 8.1 | GO:0031527 | filopodium membrane(GO:0031527) filopodium tip(GO:0032433) |
| 0.4 | 5.2 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.4 | 4.4 | GO:0031371 | ubiquitin conjugating enzyme complex(GO:0031371) |
| 0.4 | 3.6 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.4 | 3.4 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.4 | 2.5 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.4 | 2.1 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.3 | 6.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 6.5 | GO:0043219 | lateral loop(GO:0043219) |
| 0.3 | 4.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.3 | 1.0 | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.3 | 2.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 18.0 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.3 | 10.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.3 | 13.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 16.7 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.3 | 2.9 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.3 | 2.4 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.3 | 9.0 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.3 | 3.5 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.3 | 11.0 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.3 | 13.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.3 | 4.4 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.3 | 23.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.3 | 10.4 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.3 | 6.6 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.3 | 28.7 | GO:0005840 | ribosome(GO:0005840) |
| 0.3 | 21.7 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.3 | 25.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.3 | 5.1 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.3 | 10.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.2 | 3.0 | GO:0090543 | Flemming body(GO:0090543) |
| 0.2 | 0.7 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.2 | 107.0 | GO:0030529 | intracellular ribonucleoprotein complex(GO:0030529) |
| 0.2 | 5.8 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.2 | 6.7 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.2 | 1.2 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.2 | 7.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.2 | 5.0 | GO:1902562 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.2 | 2.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 20.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.2 | 3.1 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.2 | 70.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 0.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 14.7 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.2 | 7.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.2 | 7.5 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 15.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.2 | 20.5 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.2 | 1.3 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.2 | 6.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 12.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 1.3 | GO:0034464 | BBSome(GO:0034464) |
| 0.2 | 4.1 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 11.9 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 2.8 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 7.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 0.8 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.1 | 3.1 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 12.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 12.9 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 11.6 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 9.7 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 13.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 37.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 3.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 0.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 4.2 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.1 | 3.9 | GO:0032592 | integral component of mitochondrial membrane(GO:0032592) |
| 0.1 | 12.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 2.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 4.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 7.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 2.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 3.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 3.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 1.0 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 22.3 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 2.4 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.1 | 17.7 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 2.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.5 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 1.2 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 10.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 0.3 | GO:0005921 | gap junction(GO:0005921) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.2 | 91.0 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 12.6 | 37.8 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 9.8 | 58.8 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 5.6 | 66.9 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) |
| 5.5 | 16.6 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 5.3 | 21.0 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 5.0 | 15.1 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 4.5 | 13.6 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 4.4 | 13.1 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 4.3 | 89.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 4.1 | 16.2 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 3.9 | 23.5 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 3.8 | 26.9 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 3.8 | 18.9 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 3.2 | 25.5 | GO:0050733 | RS domain binding(GO:0050733) |
| 3.1 | 15.7 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 3.1 | 18.6 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 3.1 | 18.6 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 3.1 | 12.3 | GO:0033677 | DNA/RNA helicase activity(GO:0033677) |
| 3.0 | 14.8 | GO:0016936 | galactoside binding(GO:0016936) |
| 2.9 | 58.5 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 2.9 | 8.7 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 2.9 | 20.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 2.9 | 17.3 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 2.9 | 11.5 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 2.9 | 11.5 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 2.7 | 16.4 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 2.7 | 8.1 | GO:0015265 | urea channel activity(GO:0015265) |
| 2.6 | 13.2 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 2.6 | 10.4 | GO:0061752 | telomeric repeat-containing RNA binding(GO:0061752) |
| 2.6 | 7.7 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 2.5 | 12.4 | GO:0004619 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 2.5 | 9.9 | GO:0003990 | acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265) |
| 2.5 | 22.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 2.5 | 12.3 | GO:0016749 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 2.4 | 12.1 | GO:0038051 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 2.4 | 17.0 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 2.4 | 9.7 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 2.4 | 7.2 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 2.4 | 7.1 | GO:0045550 | geranylgeranyl reductase activity(GO:0045550) |
| 2.3 | 11.7 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 2.2 | 20.0 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 2.2 | 6.5 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
| 2.2 | 82.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 2.1 | 15.0 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 2.1 | 8.4 | GO:0016418 | S-acetyltransferase activity(GO:0016418) |
| 2.1 | 6.2 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 2.1 | 97.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 2.0 | 8.1 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 2.0 | 6.1 | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860) |
| 2.0 | 7.9 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 2.0 | 11.8 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 1.9 | 25.2 | GO:0046790 | virion binding(GO:0046790) |
| 1.9 | 22.8 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 1.9 | 5.7 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 1.9 | 22.7 | GO:0015266 | protein channel activity(GO:0015266) |
| 1.8 | 5.5 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 1.8 | 8.8 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 1.7 | 7.0 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 1.7 | 69.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 1.7 | 5.2 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 1.7 | 10.3 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 1.7 | 6.8 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 1.7 | 5.0 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 1.7 | 13.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 1.6 | 44.1 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 1.6 | 17.4 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 1.5 | 4.6 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 1.5 | 9.3 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 1.5 | 24.3 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 1.5 | 4.5 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 1.5 | 55.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 1.5 | 16.0 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 1.4 | 14.4 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 1.4 | 44.0 | GO:0000049 | tRNA binding(GO:0000049) |
| 1.4 | 17.0 | GO:0050700 | CARD domain binding(GO:0050700) |
| 1.4 | 7.1 | GO:0016532 | superoxide dismutase copper chaperone activity(GO:0016532) |
| 1.4 | 8.5 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 1.4 | 53.2 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 1.4 | 13.8 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 1.4 | 13.7 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 1.4 | 13.6 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 1.3 | 6.7 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 1.3 | 10.4 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 1.3 | 29.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 1.3 | 15.5 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 1.3 | 6.4 | GO:0050072 | m7G(5')pppN diphosphatase activity(GO:0050072) |
| 1.3 | 6.3 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 1.3 | 25.1 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 1.3 | 8.8 | GO:0015217 | adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217) |
| 1.2 | 10.0 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 1.2 | 4.8 | GO:0030620 | U2 snRNA binding(GO:0030620) |
| 1.2 | 8.4 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 1.2 | 4.7 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 1.1 | 5.7 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 1.1 | 9.1 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 1.1 | 4.5 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211) |
| 1.1 | 8.6 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 1.1 | 22.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 1.1 | 3.2 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 1.0 | 63.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.0 | 8.1 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 1.0 | 11.9 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 1.0 | 27.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.9 | 40.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.9 | 6.6 | GO:0102344 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 0.9 | 2.7 | GO:0018636 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.9 | 6.3 | GO:0016778 | diphosphotransferase activity(GO:0016778) |
| 0.9 | 3.6 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.9 | 19.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.9 | 18.6 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.9 | 7.0 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.9 | 15.5 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.8 | 7.6 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.8 | 15.2 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.8 | 2.5 | GO:0032428 | sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428) |
| 0.8 | 5.8 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.8 | 14.5 | GO:0016289 | CoA hydrolase activity(GO:0016289) |
| 0.8 | 183.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.8 | 18.4 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.8 | 16.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.8 | 11.9 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.8 | 2.3 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.8 | 3.1 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.8 | 3.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.8 | 6.0 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.7 | 5.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.7 | 2.0 | GO:0004958 | prostaglandin F receptor activity(GO:0004958) |
| 0.7 | 2.0 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.6 | 77.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.6 | 15.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.6 | 6.8 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.6 | 4.3 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.6 | 3.1 | GO:0004558 | alpha-1,4-glucosidase activity(GO:0004558) |
| 0.6 | 10.4 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.6 | 5.5 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.6 | 3.6 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.6 | 8.1 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.6 | 20.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.6 | 12.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.6 | 8.4 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.6 | 0.6 | GO:0004339 | glucan 1,4-alpha-glucosidase activity(GO:0004339) |
| 0.5 | 6.0 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.5 | 32.7 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.5 | 3.7 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.5 | 8.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.5 | 14.7 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.5 | 11.0 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.5 | 10.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.5 | 102.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 12.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.5 | 8.9 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.5 | 1.5 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.5 | 5.9 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.5 | 11.2 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.5 | 19.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.5 | 21.9 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.5 | 1.9 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.5 | 2.3 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.5 | 11.9 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.4 | 1.8 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.4 | 6.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.4 | 3.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.4 | 20.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 2.5 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.4 | 8.8 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.4 | 14.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.4 | 3.7 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.4 | 2.4 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.4 | 90.3 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 10.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.4 | 3.4 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.4 | 2.2 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.4 | 2.9 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.4 | 6.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.4 | 7.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.3 | 8.2 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.3 | 9.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.3 | 7.5 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.3 | 4.9 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.3 | 2.6 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.3 | 6.0 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.3 | 30.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.3 | 15.4 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.3 | 2.4 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.3 | 8.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.3 | 1.5 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.3 | 5.5 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.3 | 4.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.3 | 4.1 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.3 | 2.1 | GO:0089720 | caspase binding(GO:0089720) |
| 0.3 | 2.3 | GO:0004396 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.2 | 1.5 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.2 | 7.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 7.2 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.2 | 1.7 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.2 | 5.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.2 | 1.2 | GO:0015093 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) ferrous iron transmembrane transporter activity(GO:0015093) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.2 | 1.9 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.2 | 4.2 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.2 | 7.1 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.2 | 3.2 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.2 | 13.3 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.2 | 2.9 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.2 | 14.6 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.2 | 56.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.2 | 7.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 9.1 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 9.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 1.9 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.2 | 0.6 | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829) |
| 0.2 | 5.7 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 1.5 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.2 | 0.7 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.2 | 6.1 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.2 | 4.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 1.1 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.2 | 2.0 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.2 | 5.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.2 | 2.7 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.2 | 8.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.2 | 2.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 1.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 9.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 1.4 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.1 | 2.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.8 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 2.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 3.3 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 3.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.5 | GO:0038047 | beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047) |
| 0.1 | 1.7 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 1.5 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.1 | 40.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 1.0 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 8.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 2.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 2.3 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 2.3 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 9.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 2.1 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 2.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 7.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.1 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 3.9 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.1 | 0.2 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.1 | 8.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 0.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 0.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 3.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 1.3 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 0.2 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 0.1 | 3.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 4.3 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.1 | 1.3 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.0 | 0.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 1.9 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 11.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.7 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 1.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 17.4 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.0 | 1.0 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.2 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 0.2 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 0.2 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.0 | 0.2 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.0 | 0.8 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.1 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.3 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 0.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 35.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 2.4 | 122.4 | PID BARD1 PATHWAY | BARD1 signaling events |
| 2.1 | 78.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.7 | 8.8 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.7 | 18.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.6 | 3.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.6 | 41.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.6 | 22.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.5 | 21.7 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.5 | 8.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.5 | 10.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.5 | 87.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 32.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.5 | 22.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.5 | 22.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.4 | 26.1 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.4 | 14.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.4 | 24.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.4 | 10.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 15.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 12.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.3 | 8.2 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.3 | 5.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.3 | 6.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.3 | 22.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.3 | 13.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 25.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 27.5 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.3 | 5.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.3 | 19.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.3 | 50.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 11.2 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 2.7 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.2 | 7.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 2.5 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.2 | 2.3 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.2 | 6.1 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.2 | 4.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 5.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 4.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 3.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.2 | 0.6 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 4.6 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.1 | 2.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 6.1 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 1.5 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 9.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 2.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 7.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 2.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 4.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 6.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 5.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.6 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 2.7 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 2.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 0.6 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.1 | 1.2 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 1.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.3 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.6 | 94.7 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 3.6 | 25.2 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 3.3 | 50.2 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 3.2 | 6.4 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 3.2 | 76.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 3.2 | 113.7 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 3.0 | 107.7 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 1.9 | 61.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 1.5 | 24.0 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 1.3 | 13.2 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 1.2 | 85.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.1 | 93.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.0 | 9.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.0 | 9.9 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 1.0 | 21.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.9 | 17.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.9 | 60.4 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.9 | 16.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.9 | 52.8 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.9 | 151.5 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.8 | 20.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.8 | 22.6 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.8 | 12.8 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.7 | 11.9 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.7 | 39.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.7 | 9.1 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.6 | 11.9 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.6 | 8.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.6 | 16.6 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.6 | 9.8 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.6 | 11.5 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.6 | 5.7 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.5 | 9.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.5 | 8.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 7.2 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.5 | 13.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.5 | 13.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.5 | 8.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 16.2 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.5 | 8.0 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.5 | 5.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.5 | 11.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.5 | 6.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.5 | 14.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.4 | 6.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.4 | 48.5 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.4 | 26.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 9.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.4 | 11.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.4 | 33.2 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.4 | 13.8 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.4 | 8.4 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.4 | 11.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 7.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 7.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 47.5 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.3 | 7.0 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.3 | 4.6 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.3 | 3.1 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.3 | 28.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 5.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.2 | 3.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.2 | 11.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 5.2 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.2 | 6.5 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 2.0 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.2 | 5.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 4.6 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.2 | 3.4 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 3.9 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 3.0 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 6.3 | REACTOME SIGNALING BY FGFR1 MUTANTS | Genes involved in Signaling by FGFR1 mutants |
| 0.2 | 9.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 3.0 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 4.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 4.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 4.7 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.1 | 2.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 4.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 6.2 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 1.0 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.1 | 4.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 1.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 5.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 3.8 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 3.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 2.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 0.6 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 1.3 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.1 | 13.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 0.6 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.1 | 1.7 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.1 | 3.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 3.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 2.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.5 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.8 | REACTOME GABA RECEPTOR ACTIVATION | Genes involved in GABA receptor activation |
| 0.0 | 1.8 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 1.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.2 | REACTOME OPSINS | Genes involved in Opsins |