ISMARA results: SMAD3

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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SMAD3

Z-value: 2.29

Motif logo

Transcription factors associated with SMAD3

Gene Symbol	Gene ID	Gene Info
SMAD3 Ensembl NCBI GeneCards UniProt	ENSG00000166949.17	SMAD3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD3	hg38_v1_chr15_+_67128103_67128269	0.19	4.3e-03	Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

View svg image
View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr6_+_27147094 Show fit	12.36	ENST00000377459.3	H2AC12 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 12
chr10_-_88952763 Show fit	11.66	ENST00000224784.10	ACTA2 Ensembl NCBI GeneCards UniProt Show fit	actin alpha 2, smooth muscle
chr22_-_35617321 Show fit	8.82	ENST00000397326.7 ENST00000442617.1	MB Ensembl NCBI GeneCards UniProt Show fit	myoglobin
chr3_+_125969172 Show fit	7.28	ENST00000514116.6 ENST00000513830.5	ROPN1B Ensembl NCBI GeneCards UniProt Show fit	rhophilin associated tail protein 1B
chrX_+_47585212 Show fit	7.23	ENST00000445623.1	TIMP1 Ensembl NCBI GeneCards UniProt Show fit	TIMP metallopeptidase inhibitor 1
chr3_+_125969152 Show fit	7.02	ENST00000251776.8 ENST00000504401.1	ROPN1B Ensembl NCBI GeneCards UniProt Show fit	rhophilin associated tail protein 1B
chr3_+_125969214 Show fit	6.81	ENST00000508088.1	ROPN1B Ensembl NCBI GeneCards UniProt Show fit	rhophilin associated tail protein 1B
chr3_-_123992046 Show fit	6.57	ENST00000467907.5 ENST00000459660.5 ENST00000495093.1 ENST00000460743.5 ENST00000405845.7 ENST00000484329.1 ENST00000479867.1 ENST00000496145.5	ROPN1 Ensembl NCBI GeneCards UniProt Show fit	rhophilin associated tail protein 1
chr6_-_27146841 Show fit	6.19	ENST00000356950.2	H2BC12 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 12
chr14_-_20802402 Show fit	6.13	ENST00000412779.2	RNASE1 Ensembl NCBI GeneCards UniProt Show fit	ribonuclease A family member 1, pancreatic
chr6_-_27814757 Show fit	5.98	ENST00000333151.5	H2AC14 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 14
chr2_-_219245389 Show fit	5.53	ENST00000428427.1 ENST00000432839.1 ENST00000295759.12 ENST00000424620.1	GLB1L Ensembl NCBI GeneCards UniProt Show fit	galactosidase beta 1 like
chr15_-_82647503 Show fit	5.05	ENST00000567678.1 ENST00000620182.4	CPEB1 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic polyadenylation element binding protein 1
chr2_-_219245465 Show fit	4.85	ENST00000392089.6	GLB1L Ensembl NCBI GeneCards UniProt Show fit	galactosidase beta 1 like
chr3_+_12796662 Show fit	4.81	ENST00000456430.6 ENST00000626378.1	CAND2 Ensembl NCBI GeneCards UniProt Show fit	cullin associated and neddylation dissociated 2 (putative)
chr10_+_28677487 Show fit	4.80	ENST00000375533.6	BAMBI Ensembl NCBI GeneCards UniProt Show fit	BMP and activin membrane bound inhibitor
chr15_-_82647960 Show fit	4.78	ENST00000615198.4	CPEB1 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic polyadenylation element binding protein 1
chr6_+_27808163 Show fit	4.60	ENST00000358739.4	H2AC13 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 13
chr11_+_117199363 Show fit	4.40	ENST00000392951.9 ENST00000525531.5 ENST00000278968.10	TAGLN Ensembl NCBI GeneCards UniProt Show fit	transgelin
chr6_-_27132750 Show fit	4.34	ENST00000607124.1 ENST00000339812.3	H2BC11 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 11
chr15_-_82647336 Show fit	4.18	ENST00000617522.4 ENST00000684509.1	CPEB1 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic polyadenylation element binding protein 1
chr4_-_185775271 Show fit	3.94	ENST00000430503.5 ENST00000319454.10 ENST00000450341.5	SORBS2 Ensembl NCBI GeneCards UniProt Show fit	sorbin and SH3 domain containing 2
chr6_-_27807916 Show fit	3.68	ENST00000377401.3	H2BC13 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 13
chr17_-_40937445 Show fit	3.65	ENST00000436344.7 ENST00000485751.1	KRT23 Ensembl NCBI GeneCards UniProt Show fit	keratin 23
chr6_-_27893175 Show fit	3.64	ENST00000359611.4	H2AC17 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 17
chr6_+_27838600 Show fit	3.52	ENST00000606613.1	H2BC15 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 15
chr19_-_11577632 Show fit	3.47	ENST00000590420.1 ENST00000648477.1	ACP5 Ensembl NCBI GeneCards UniProt Show fit	acid phosphatase 5, tartrate resistant
chr22_+_41560973 Show fit	3.44	ENST00000306149.12	CSDC2 Ensembl NCBI GeneCards UniProt Show fit	cold shock domain containing C2
chr11_-_72434330 Show fit	3.35	ENST00000542555.2 ENST00000535990.5 ENST00000294053.9 ENST00000538039.6 ENST00000340729.9	CLPB Ensembl NCBI GeneCards UniProt Show fit	caseinolytic mitochondrial matrix peptidase chaperone subunit B
chr14_+_92923143 Show fit	3.33	ENST00000216492.10 ENST00000334654.4	CHGA Ensembl NCBI GeneCards UniProt Show fit	chromogranin A
chr6_+_27815010 Show fit	3.22	ENST00000621112.2	H2BC14 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 14
chr1_-_9069608 Show fit	3.17	ENST00000377424.9	SLC2A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 2 member 5
chr6_+_26124161 Show fit	3.07	ENST00000377791.4 ENST00000602637.1	H2AC6 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 6
chr20_-_23049659 Show fit	3.05	ENST00000377103.3	THBD Ensembl NCBI GeneCards UniProt Show fit	thrombomodulin
chr6_-_26216673 Show fit	3.02	ENST00000541790.3	H2BC8 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 8
chr6_-_11807045 Show fit	2.97	ENST00000379415.6	ADTRP Ensembl NCBI GeneCards UniProt Show fit	androgen dependent TFPI regulating protein
chr6_+_27133032 Show fit	2.90	ENST00000359193.3	H2AC11 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 11
chr1_-_225941383 Show fit	2.66	ENST00000420304.6	LEFTY2 Ensembl NCBI GeneCards UniProt Show fit	left-right determination factor 2
chrX_+_49829260 Show fit	2.56	ENST00000376141.5 ENST00000218068.7	PAGE4 Ensembl NCBI GeneCards UniProt Show fit	PAGE family member 4
chr9_+_5890872 Show fit	2.52	ENST00000381477.8 ENST00000381476.5 ENST00000381471.1	MLANA Ensembl NCBI GeneCards UniProt Show fit	melan-A
chr2_-_128028010 Show fit	2.45	ENST00000643581.2 ENST00000450957.1	SAP130 Ensembl NCBI GeneCards UniProt Show fit	Sin3A associated protein 130
chr17_+_50095331 Show fit	2.45	ENST00000503176.6	PDK2 Ensembl NCBI GeneCards UniProt Show fit	pyruvate dehydrogenase kinase 2
chr6_+_26272923 Show fit	2.36	ENST00000377733.4	H2BC10 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 10
chr2_-_217944005 Show fit	2.35	ENST00000611415.4 ENST00000615025.5 ENST00000449814.1 ENST00000171887.8	TNS1 Ensembl NCBI GeneCards UniProt Show fit	tensin 1
chr6_+_26216928 Show fit	2.34	ENST00000303910.4	H2AC8 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 8
chr9_-_127847117 Show fit	2.31	ENST00000480266.5	ENG Ensembl NCBI GeneCards UniProt Show fit	endoglin
chr1_-_225941212 Show fit	2.27	ENST00000366820.10	LEFTY2 Ensembl NCBI GeneCards UniProt Show fit	left-right determination factor 2
chr6_-_27831557 Show fit	2.26	ENST00000611927.2	H4C12 Ensembl NCBI GeneCards UniProt Show fit	H4 clustered histone 12
chr2_-_128028114 Show fit	2.26	ENST00000259234.10	SAP130 Ensembl NCBI GeneCards UniProt Show fit	Sin3A associated protein 130
chrX_-_111270474 Show fit	2.25	ENST00000324068.2	CAPN6 Ensembl NCBI GeneCards UniProt Show fit	calpain 6
chr2_-_128027273 Show fit	2.24	ENST00000259235.7 ENST00000357702.9 ENST00000424298.5	SAP130 Ensembl NCBI GeneCards UniProt Show fit	Sin3A associated protein 130
chr19_+_51225059 Show fit	2.22	ENST00000436584.6 ENST00000421133.6 ENST00000262262.5 ENST00000391796.7	CD33 Ensembl NCBI GeneCards UniProt Show fit	CD33 molecule
chr7_+_139829242 Show fit	2.15	ENST00000455353.6 ENST00000458722.6 ENST00000448866.7 ENST00000411653.6	TBXAS1 Ensembl NCBI GeneCards UniProt Show fit	thromboxane A synthase 1
chr6_+_146598961 Show fit	2.08	ENST00000522242.5 ENST00000397944.8	ADGB Ensembl NCBI GeneCards UniProt Show fit	androglobin
chr17_+_72121012 Show fit	2.05	ENST00000245479.3	SOX9 Ensembl NCBI GeneCards UniProt Show fit	SRY-box transcription factor 9
chr5_-_69332723 Show fit	2.03	ENST00000511257.1 ENST00000396496.7 ENST00000383374.6	CCDC125 Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 125
chrX_-_154295085 Show fit	2.01	ENST00000617225.4 ENST00000619903.4	TEX28 Ensembl NCBI GeneCards UniProt Show fit	testis expressed 28
chr16_-_375205 Show fit	1.96	ENST00000448854.1	PGAP6 Ensembl NCBI GeneCards UniProt Show fit	post-glycosylphosphatidylinositol attachment to proteins 6
chr6_+_292050 Show fit	1.95	ENST00000344450.9	DUSP22 Ensembl NCBI GeneCards UniProt Show fit	dual specificity phosphatase 22
chr12_+_119178920 Show fit	1.93	ENST00000281938.7	HSPB8 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 8
chr19_-_40850442 Show fit	1.91	ENST00000301141.10	CYP2A6 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 2 subfamily A member 6
chr12_-_110502065 Show fit	1.89	ENST00000447578.6 ENST00000546588.1 ENST00000360579.11 ENST00000549578.6 ENST00000549970.5	VPS29 Ensembl NCBI GeneCards UniProt Show fit	VPS29 retromer complex component
chrX_+_50067576 Show fit	1.87	ENST00000376108.7	CLCN5 Ensembl NCBI GeneCards UniProt Show fit	chloride voltage-gated channel 5
chr2_+_203867943 Show fit	1.84	ENST00000295854.10 ENST00000487393.1 ENST00000472206.1	CTLA4 Ensembl NCBI GeneCards UniProt Show fit	cytotoxic T-lymphocyte associated protein 4
chr6_+_27824084 Show fit	1.81	ENST00000355057.3	H4C11 Ensembl NCBI GeneCards UniProt Show fit	H4 clustered histone 11
chr12_+_119178953 Show fit	1.73	ENST00000674542.1	HSPB8 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 8
chr6_+_52423680 Show fit	1.71	ENST00000538167.2	EFHC1 Ensembl NCBI GeneCards UniProt Show fit	EF-hand domain containing 1
chr5_-_180815528 Show fit	1.70	ENST00000333055.8	MGAT1 Ensembl NCBI GeneCards UniProt Show fit	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
chr18_+_32018817 Show fit	1.67	ENST00000217740.4 ENST00000583184.1	RNF125 Ensembl NCBI GeneCards UniProt Show fit ENSG00000263917.1 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 125 novel transcript
chr11_+_116830529 Show fit	1.66	ENST00000630701.1	APOC3 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein C3
chr10_+_92691813 Show fit	1.64	ENST00000472590.6	HHEX Ensembl NCBI GeneCards UniProt Show fit	hematopoietically expressed homeobox
chr1_-_110607307 Show fit	1.63	ENST00000639048.2 ENST00000675391.1 ENST00000639233.2	KCNA2 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily A member 2
chr11_+_116829898 Show fit	1.63	ENST00000227667.8 ENST00000375345.3	APOC3 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein C3
chr22_+_20080211 Show fit	1.62	ENST00000383024.6 ENST00000351989.8	DGCR8 Ensembl NCBI GeneCards UniProt Show fit	DGCR8 microprocessor complex subunit
chr1_-_8817633 Show fit	1.59	ENST00000400908.7	RERE Ensembl NCBI GeneCards UniProt Show fit	arginine-glutamic acid dipeptide repeats
chr3_+_51707059 Show fit	1.57	ENST00000395052.8	GRM2 Ensembl NCBI GeneCards UniProt Show fit	glutamate metabotropic receptor 2
chr12_+_25958891 Show fit	1.53	ENST00000381352.7 ENST00000535907.5 ENST00000405154.6 ENST00000615708.4	RASSF8 Ensembl NCBI GeneCards UniProt Show fit	Ras association domain family member 8
chr11_+_113387773 Show fit	1.50	ENST00000303941.4	ANKK1 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and kinase domain containing 1
chr1_-_110607425 Show fit	1.50	ENST00000633222.1	KCNA2 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily A member 2
chr1_+_149832647 Show fit	1.47	ENST00000578186.2	H4C14 Ensembl NCBI GeneCards UniProt Show fit	H4 clustered histone 14
chr11_+_118610374 Show fit	1.38	ENST00000532639.3	PHLDB1 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology like domain family B member 1
chr11_+_73272201 Show fit	1.33	ENST00000393590.3	P2RY6 Ensembl NCBI GeneCards UniProt Show fit	pyrimidinergic receptor P2Y6
chr2_+_203867764 Show fit	1.30	ENST00000648405.2	CTLA4 Ensembl NCBI GeneCards UniProt Show fit	cytotoxic T-lymphocyte associated protein 4
chr1_+_173824626 Show fit	1.30	ENST00000648960.1 ENST00000648807.1 ENST00000649067.1 ENST00000649689.2	DARS2 Ensembl NCBI GeneCards UniProt Show fit	aspartyl-tRNA synthetase 2, mitochondrial
chr17_-_3292600 Show fit	1.30	ENST00000615105.1	OR3A1 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor family 3 subfamily A member 1
chr15_+_81299416 Show fit	1.29	ENST00000558332.3	IL16 Ensembl NCBI GeneCards UniProt Show fit	interleukin 16
chr6_-_26033609 Show fit	1.28	ENST00000615868.2	H2AC4 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 4
chr7_+_120988683 Show fit	1.28	ENST00000340646.9 ENST00000310396.10	CPED1 Ensembl NCBI GeneCards UniProt Show fit	cadherin like and PC-esterase domain containing 1
chr11_+_61102465 Show fit	1.27	ENST00000347785.8 ENST00000544014.1	CD5 Ensembl NCBI GeneCards UniProt Show fit	CD5 molecule
chr17_-_18682262 Show fit	1.22	ENST00000454745.2 ENST00000395675.7	FOXO3B Ensembl NCBI GeneCards UniProt Show fit	forkhead box O3B
chr1_+_173824694 Show fit	1.21	ENST00000647645.1	DARS2 Ensembl NCBI GeneCards UniProt Show fit	aspartyl-tRNA synthetase 2, mitochondrial
chr5_+_141245384 Show fit	1.20	ENST00000623671.1 ENST00000231173.6	PCDHB15 Ensembl NCBI GeneCards UniProt Show fit	protocadherin beta 15
chr6_-_46954922 Show fit	1.17	ENST00000265417.7	ADGRF5 Ensembl NCBI GeneCards UniProt Show fit	adhesion G protein-coupled receptor F5
chr14_-_64942720 Show fit	1.14	ENST00000557049.1 ENST00000389614.6	GPX2 Ensembl NCBI GeneCards UniProt Show fit	glutathione peroxidase 2
chr4_+_54657918 Show fit	1.13	ENST00000412167.6 ENST00000288135.6	KIT Ensembl NCBI GeneCards UniProt Show fit	KIT proto-oncogene, receptor tyrosine kinase
chr16_-_84187026 Show fit	1.13	ENST00000561955.1 ENST00000564454.1 ENST00000341690.10 ENST00000566732.6 ENST00000570117.5 ENST00000564345.5 ENST00000541676.5	TAF1C Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor, RNA polymerase I subunit C
chr14_+_91114431 Show fit	1.11	ENST00000428926.6 ENST00000517362.5	DGLUCY Ensembl NCBI GeneCards UniProt Show fit	D-glutamate cyclase
chr6_+_27893411 Show fit	1.11	ENST00000616182.2	H2BC17 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 17
chr11_-_64744993 Show fit	1.06	ENST00000377485.5	RASGRP2 Ensembl NCBI GeneCards UniProt Show fit	RAS guanyl releasing protein 2
chr16_-_20669855 Show fit	1.05	ENST00000524149.5	ACSM1 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase medium chain family member 1
chr6_-_26189101 Show fit	1.05	ENST00000614247.2	H4C4 Ensembl NCBI GeneCards UniProt Show fit	H4 clustered histone 4
chr12_+_49741544 Show fit	1.05	ENST00000549966.5 ENST00000547832.5 ENST00000547187.5 ENST00000548894.5 ENST00000546914.5 ENST00000552699.5 ENST00000267115.10	TMBIM6 Ensembl NCBI GeneCards UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr14_+_91114388 Show fit	1.03	ENST00000519019.5 ENST00000523816.5 ENST00000517518.5	DGLUCY Ensembl NCBI GeneCards UniProt Show fit	D-glutamate cyclase
chr16_-_84186998 Show fit	1.03	ENST00000567759.5	TAF1C Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor, RNA polymerase I subunit C
chr9_-_34691204 Show fit	1.02	ENST00000378800.3 ENST00000311925.7	CCL19 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 19
chr14_-_64942783 Show fit	1.00	ENST00000612794.1	GPX2 Ensembl NCBI GeneCards UniProt Show fit	glutathione peroxidase 2
chr4_+_186069144 Show fit	0.99	ENST00000513189.1 ENST00000296795.8	TLR3 Ensembl NCBI GeneCards UniProt Show fit	toll like receptor 3
chr14_+_21868822 Show fit	0.99	ENST00000390436.2	TRAV13-1 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor alpha variable 13-1
chr14_+_91114364 Show fit	0.99	ENST00000518868.5	DGLUCY Ensembl NCBI GeneCards UniProt Show fit	D-glutamate cyclase
chr5_+_141150012 Show fit	0.98	ENST00000231136.4 ENST00000622991.1	PCDHB6 Ensembl NCBI GeneCards UniProt Show fit	protocadherin beta 6
chr14_-_58152179 Show fit	0.96	ENST00000267485.7	ARMH4 Ensembl NCBI GeneCards UniProt Show fit	armadillo like helical domain containing 4
chr18_+_13218195 Show fit	0.95	ENST00000679167.1	LDLRAD4 Ensembl NCBI GeneCards UniProt Show fit	low density lipoprotein receptor class A domain containing 4
chr6_-_26123910 Show fit	0.95	ENST00000314332.5 ENST00000396984.1	H2BC4 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 4
chr14_+_91114667 Show fit	0.93	ENST00000523894.5 ENST00000522322.5 ENST00000523771.5	DGLUCY Ensembl NCBI GeneCards UniProt Show fit	D-glutamate cyclase
chr14_+_91114026 Show fit	0.87	ENST00000521081.5 ENST00000520328.5 ENST00000524232.5 ENST00000522170.5 ENST00000256324.15 ENST00000519950.5 ENST00000523879.5 ENST00000521077.6 ENST00000518665.6	DGLUCY Ensembl NCBI GeneCards UniProt Show fit	D-glutamate cyclase
chr1_+_66332004 Show fit	0.87	ENST00000371045.9 ENST00000531025.5 ENST00000526197.5	PDE4B Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 4B
chr6_-_53148822 Show fit	0.86	ENST00000259803.8	GCM1 Ensembl NCBI GeneCards UniProt Show fit	glial cells missing transcription factor 1
chr11_+_124954108 Show fit	0.81	ENST00000529051.5	CCDC15 Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 15
chr3_-_14178569 Show fit	0.80	ENST00000285021.12	XPC Ensembl NCBI GeneCards UniProt Show fit	XPC complex subunit, DNA damage recognition and repair factor
chrX_-_49073989 Show fit	0.79	ENST00000376386.3 ENST00000553851.3	PRAF2 Ensembl NCBI GeneCards UniProt Show fit	PRA1 domain family member 2
chr16_+_30472733 Show fit	0.78	ENST00000356798.11 ENST00000433423.2	ITGAL Ensembl NCBI GeneCards UniProt Show fit	integrin subunit alpha L
chr2_-_79086847 Show fit	0.76	ENST00000454188.5	REG1B Ensembl NCBI GeneCards UniProt Show fit	regenerating family member 1 beta
chr10_+_92691897 Show fit	0.75	ENST00000492654.3	HHEX Ensembl NCBI GeneCards UniProt Show fit	hematopoietically expressed homeobox
chr3_-_52897541 Show fit	0.75	ENST00000355083.11 ENST00000504329.1	STIMATE Ensembl NCBI GeneCards UniProt Show fit STIMATE-MUSTN1 Ensembl NCBI GeneCards UniProt Show fit	STIM activating enhancer STIMATE-MUSTN1 readthrough
chr5_-_128339191 Show fit	0.74	ENST00000507835.5	FBN2 Ensembl NCBI GeneCards UniProt Show fit	fibrillin 2
chr1_-_160862880 Show fit	0.70	ENST00000368034.9	CD244 Ensembl NCBI GeneCards UniProt Show fit	CD244 molecule
chr12_+_49741565 Show fit	0.70	ENST00000549445.5 ENST00000550951.5 ENST00000549385.5 ENST00000548713.5 ENST00000548201.5	TMBIM6 Ensembl NCBI GeneCards UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr4_+_2812259 Show fit	0.68	ENST00000502260.5 ENST00000435136.8	SH3BP2 Ensembl NCBI GeneCards UniProt Show fit	SH3 domain binding protein 2
chr2_-_49154433 Show fit	0.67	ENST00000454032.5 ENST00000304421.8	FSHR Ensembl NCBI GeneCards UniProt Show fit	follicle stimulating hormone receptor
chr2_+_219245455 Show fit	0.66	ENST00000409638.7 ENST00000396738.7 ENST00000409516.7	STK16 Ensembl NCBI GeneCards UniProt Show fit	serine/threonine kinase 16
chr1_-_9069572 Show fit	0.65	ENST00000377414.7	SLC2A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 2 member 5
chr18_+_13612614 Show fit	0.64	ENST00000586765.1 ENST00000677910.1	LDLRAD4 Ensembl NCBI GeneCards UniProt Show fit	low density lipoprotein receptor class A domain containing 4
chr11_+_66638678 Show fit	0.62	ENST00000578778.5 ENST00000483858.5 ENST00000398692.8 ENST00000310092.12 ENST00000510173.6 ENST00000506523.6 ENST00000530235.1 ENST00000532968.1	RBM4 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 4
chr21_+_44133610 Show fit	0.60	ENST00000644251.1 ENST00000427803.6 ENST00000348499.9 ENST00000291577.11 ENST00000389690.7	GATD3A Ensembl NCBI GeneCards UniProt Show fit	glutamine amidotransferase like class 1 domain containing 3A
chr15_-_82709775 Show fit	0.60	ENST00000535348.5	AP3B2 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 3 subunit beta 2
chr4_-_26490453 Show fit	0.59	ENST00000295589.4	CCKAR Ensembl NCBI GeneCards UniProt Show fit	cholecystokinin A receptor
chr11_+_62771357 Show fit	0.58	ENST00000526261.1 ENST00000294168.8	TAF6L Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 6 like
chr14_-_24081928 Show fit	0.55	ENST00000396995.1	NRL Ensembl NCBI GeneCards UniProt Show fit	neural retina leucine zipper
chr15_-_82709886 Show fit	0.52	ENST00000666055.1 ENST00000261722.8 ENST00000535513.2	AP3B2 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 3 subunit beta 2
chr19_-_55180010 Show fit	0.49	ENST00000589172.5	SYT5 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 5
chr15_-_82709859 Show fit	0.47	ENST00000542200.2 ENST00000535359.6 ENST00000668990.2 ENST00000652847.1	AP3B2 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 3 subunit beta 2
chr2_-_49154507 Show fit	0.47	ENST00000406846.7	FSHR Ensembl NCBI GeneCards UniProt Show fit	follicle stimulating hormone receptor
chr16_-_3256587 Show fit	0.46	ENST00000536379.5 ENST00000541159.5 ENST00000339854.8 ENST00000219596.6	MEFV Ensembl NCBI GeneCards UniProt Show fit	MEFV innate immuity regulator, pyrin
chr7_-_101211672 Show fit	0.43	ENST00000454310.5	PLOD3 Ensembl NCBI GeneCards UniProt Show fit	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
chr2_-_135837170 Show fit	0.42	ENST00000264162.7	LCT Ensembl NCBI GeneCards UniProt Show fit	lactase
chr1_-_20787287 Show fit	0.42	ENST00000438032.6 ENST00000424732.5 ENST00000437575.5	HP1BP3 Ensembl NCBI GeneCards UniProt Show fit	heterochromatin protein 1 binding protein 3
chr14_-_106622837 Show fit	0.39	ENST00000390628.3	IGHV1-58 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1-58
chr4_+_40335324 Show fit	0.39	ENST00000310169.3	CHRNA9 Ensembl NCBI GeneCards UniProt Show fit	cholinergic receptor nicotinic alpha 9 subunit
chr12_+_49741802 Show fit	0.38	ENST00000423828.5 ENST00000550445.5	TMBIM6 Ensembl NCBI GeneCards UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr19_+_42220283 Show fit	0.38	ENST00000301215.8 ENST00000597945.1	ZNF526 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 526
chr1_-_110607816 Show fit	0.37	ENST00000485317.6	KCNA2 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily A member 2
chr18_+_13611764 Show fit	0.36	ENST00000585931.5	LDLRAD4 Ensembl NCBI GeneCards UniProt Show fit	low density lipoprotein receptor class A domain containing 4
chr15_-_82709823 Show fit	0.36	ENST00000666973.1 ENST00000664460.1 ENST00000669930.1	AP3B2 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 3 subunit beta 2
chr1_-_110607970 Show fit	0.35	ENST00000638532.1	KCNA2 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily A member 2
chr18_+_46174014 Show fit	0.35	ENST00000619301.4 ENST00000615052.5	C18orf25 Ensembl NCBI GeneCards UniProt Show fit	chromosome 18 open reading frame 25
chr1_+_153416517 Show fit	0.33	ENST00000368729.9	S100A7A Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A7A
chr6_-_41921081 Show fit	0.33	ENST00000409060.1	MED20 Ensembl NCBI GeneCards UniProt Show fit	mediator complex subunit 20
chr14_-_24081986 Show fit	0.32	ENST00000560550.1	NRL Ensembl NCBI GeneCards UniProt Show fit	neural retina leucine zipper
chr1_-_9129085 Show fit	0.30	ENST00000377411.5	GPR157 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 157
chr6_+_30882914 Show fit	0.28	ENST00000509639.5 ENST00000412274.6 ENST00000507901.5 ENST00000507046.5 ENST00000437124.6 ENST00000454612.6 ENST00000396342.6	DDR1 Ensembl NCBI GeneCards UniProt Show fit	discoidin domain receptor tyrosine kinase 1
chr16_+_2471284 Show fit	0.26	ENST00000293973.2	NTN3 Ensembl NCBI GeneCards UniProt Show fit	netrin 3
chr6_-_26027274 Show fit	0.24	ENST00000377745.4	H4C2 Ensembl NCBI GeneCards UniProt Show fit	H4 clustered histone 2
chr3_-_120647018 Show fit	0.23	ENST00000475447.2	HGD Ensembl NCBI GeneCards UniProt Show fit	homogentisate 1,2-dioxygenase
chr17_+_4710622 Show fit	0.22	ENST00000574954.5 ENST00000269260.7 ENST00000346341.6 ENST00000572457.5 ENST00000381488.10 ENST00000412477.7 ENST00000571428.5 ENST00000575877.5	ARRB2 Ensembl NCBI GeneCards UniProt Show fit	arrestin beta 2
chr19_+_41088450 Show fit	0.21	ENST00000330436.4	CYP2A13 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 2 subfamily A member 13
chr10_+_116591010 Show fit	0.21	ENST00000530319.5 ENST00000527980.5 ENST00000471549.5 ENST00000534537.5	PNLIPRP1 Ensembl NCBI GeneCards UniProt Show fit	pancreatic lipase related protein 1
chr1_-_160070150 Show fit	0.20	ENST00000644903.1	KCNJ10 Ensembl NCBI GeneCards UniProt Show fit	potassium inwardly rectifying channel subfamily J member 10
chr12_-_9760893 Show fit	0.19	ENST00000228434.7 ENST00000536709.1	CD69 Ensembl NCBI GeneCards UniProt Show fit	CD69 molecule
chr1_-_152036984 Show fit	0.18	ENST00000271638.3	S100A11 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A11
chr10_+_116590956 Show fit	0.18	ENST00000358834.9 ENST00000528052.5	PNLIPRP1 Ensembl NCBI GeneCards UniProt Show fit	pancreatic lipase related protein 1
chr6_-_27838362 Show fit	0.18	ENST00000618958.2	H2AC15 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 15
chr6_-_41921105 Show fit	0.15	ENST00000434077.1 ENST00000409312.5 ENST00000265350.9	MED20 Ensembl NCBI GeneCards UniProt Show fit	mediator complex subunit 20
chr16_+_30472700 Show fit	0.12	ENST00000358164.9	ITGAL Ensembl NCBI GeneCards UniProt Show fit	integrin subunit alpha L
chr12_+_67648737 Show fit	0.12	ENST00000344096.4 ENST00000393555.3	DYRK2 Ensembl NCBI GeneCards UniProt Show fit	dual specificity tyrosine phosphorylation regulated kinase 2
chr19_-_45645560 Show fit	0.07	ENST00000587152.6	EML2 Ensembl NCBI GeneCards UniProt Show fit	EMAP like 2
chr1_-_160070102 Show fit	0.07	ENST00000638728.1 ENST00000637644.1	KCNJ10 Ensembl NCBI GeneCards UniProt Show fit	potassium inwardly rectifying channel subfamily J member 10
chr20_-_63463843 Show fit	0.07	ENST00000637193.1	KCNQ2 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily Q member 2
chr1_-_44017296 Show fit	0.01	ENST00000357730.6 ENST00000360584.6 ENST00000528803.1	SLC6A9 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 9
chr11_+_66638661 Show fit	0.01	ENST00000396053.9 ENST00000408993.6	RBM4 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.3	11.7	GO:0090131	mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131)
1.4	14.0	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
1.2	7.2	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
1.1	3.3	GO:1901899	positive regulation of relaxation of cardiac muscle(GO:1901899)
1.0	21.1	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
1.0	8.8	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
1.0	2.9	GO:0060018	astrocyte fate commitment(GO:0060018)
1.0	1.9	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.8	2.5	GO:0006421	asparaginyl-tRNA aminoacylation(GO:0006421)
0.8	3.3	GO:2000910	regulation of high-density lipoprotein particle clearance(GO:0010982) regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.8	2.4	GO:0061011	hepatic duct development(GO:0061011)
0.8	2.3	GO:0001300	chronological cell aging(GO:0001300)
0.7	3.5	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.6	3.1	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.4	1.7	GO:0006049	UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.4	1.6	GO:0021691	cerebellar Purkinje cell layer maturation(GO:0021691)
0.4	3.9	GO:0021633	optic nerve structural organization(GO:0021633)
0.4	1.1	GO:0001545	primary ovarian follicle growth(GO:0001545)
0.4	1.1	GO:0070662	mast cell proliferation(GO:0070662)
0.4	2.1	GO:1904721	negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.4	1.1	GO:0019605	benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.4	3.2	GO:0010265	SCF complex assembly(GO:0010265)
0.3	1.0	GO:2000547	dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
0.3	3.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.3	1.5	GO:0034334	adherens junction maintenance(GO:0034334)
0.2	1.0	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.2	0.7	GO:2000566	CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.2	3.5	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.2	0.9	GO:0045872	positive regulation of rhodopsin gene expression(GO:0045872)
0.2	1.0	GO:0097319	fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.2	0.5	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1	2.4	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	2.0	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.1	1.7	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.1	1.4	GO:1904261	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.1	0.6	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	1.6	GO:0031053	primary miRNA processing(GO:0031053)
0.1	1.3	GO:0030321	transepithelial chloride transport(GO:0030321)
0.1	0.4	GO:0046946	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1	1.2	GO:0043129	surfactant homeostasis(GO:0043129)
0.1	0.7	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1	2.2	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.1	1.9	GO:1990126	retrograde transport, endosome to plasma membrane(GO:1990126)
0.1	3.9	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1	2.0	GO:0099517	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1	1.6	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1	6.1	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1	4.9	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1	0.9	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	1.9	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	0.9	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.1	0.3	GO:0051935	amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1	1.3	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.1	0.4	GO:0044245	polysaccharide digestion(GO:0044245)
0.1	0.2	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.8	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.4	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0	2.2	GO:0006356	regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0	0.2	GO:0009698	phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0	0.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	1.9	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
0.0	2.4	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	6.6	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.2	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	2.3	GO:0001578	microtubule bundle formation(GO:0001578)
0.0	0.3	GO:0060019	radial glial cell differentiation(GO:0060019)
0.0	3.0	GO:0070268	cornification(GO:0070268)
0.0	1.0	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	0.8	GO:0015813	L-glutamate transport(GO:0015813)
0.0	1.7	GO:0021795	cerebral cortex cell migration(GO:0021795)
0.0	0.4	GO:0070828	heterochromatin organization(GO:0070828)
0.0	3.4	GO:0043488	regulation of mRNA stability(GO:0043488)
0.0	1.3	GO:0031295	T cell costimulation(GO:0031295)
0.0	1.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	1.1	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.9	11.7	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.8	2.3	GO:0072563	endothelial microparticle(GO:0072563)
0.6	1.9	GO:0030906	retromer, cargo-selective complex(GO:0030906)
0.6	14.0	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.5	3.3	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.4	2.2	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.4	2.4	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3	6.9	GO:0070822	Sin3-type complex(GO:0070822)
0.2	3.9	GO:0033010	paranodal junction(GO:0033010)
0.2	3.3	GO:0042583	chromaffin granule(GO:0042583)
0.2	0.8	GO:0071942	XPC complex(GO:0071942)
0.2	1.4	GO:0045180	basal cortex(GO:0045180)
0.2	0.9	GO:0034687	integrin alphaL-beta2 complex(GO:0034687)
0.1	20.6	GO:0031514	motile cilium(GO:0031514)
0.1	2.0	GO:0030123	AP-3 adaptor complex(GO:0030123)
0.1	12.2	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	1.7	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1	3.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	3.1	GO:0098636	protein complex involved in cell adhesion(GO:0098636)
0.0	1.2	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	1.0	GO:0036020	endolysosome membrane(GO:0036020)
0.0	1.6	GO:1902555	endoribonuclease complex(GO:1902555)
0.0	0.9	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.7	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.6	GO:0030914	STAGA complex(GO:0030914)
0.0	1.1	GO:0042629	mast cell granule(GO:0042629)
0.0	1.9	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	1.8	GO:0005876	spindle microtubule(GO:0005876)
0.0	1.7	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0	3.3	GO:0035579	specific granule membrane(GO:0035579)
0.0	1.6	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.4	GO:0000786	nucleosome(GO:0000786)
0.0	3.0	GO:0005882	intermediate filament(GO:0005882)
0.0	3.9	GO:0030018	Z disc(GO:0030018)
0.0	0.4	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.4	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	1.6	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.5	GO:0016592	mediator complex(GO:0016592)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	6.1	GO:0004522	ribonuclease A activity(GO:0004522)
1.2	10.4	GO:0004565	beta-galactosidase activity(GO:0004565)
0.7	14.0	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.7	2.2	GO:0036134	thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.7	3.3	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.6	7.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.6	8.8	GO:0005344	oxygen transporter activity(GO:0005344)
0.5	1.6	GO:0008267	poly-glutamine tract binding(GO:0008267)
0.5	1.6	GO:0001641	group II metabotropic glutamate receptor activity(GO:0001641)
0.5	21.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.4	1.7	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.4	2.4	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.4	1.1	GO:0004963	follicle-stimulating hormone receptor activity(GO:0004963)
0.3	7.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.3	2.1	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.3	1.6	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.3	3.5	GO:0008199	ferric iron binding(GO:0008199)
0.2	2.7	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.2	1.3	GO:0045029	UDP-activated nucleotide receptor activity(GO:0045029)
0.2	1.0	GO:0005353	fructose transmembrane transporter activity(GO:0005353)
0.2	3.9	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.2	1.0	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.2	3.9	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.1	0.8	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.1	0.9	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.1	2.4	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	2.1	GO:0008391	arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1	2.5	GO:0016876	aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1	4.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1	0.4	GO:0050211	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.1	0.4	GO:0008422	beta-glucosidase activity(GO:0008422)
0.1	1.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.1	0.7	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023)
0.1	2.2	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1	1.9	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.1	2.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	1.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1	1.3	GO:0042609	CD4 receptor binding(GO:0042609)
0.1	3.6	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.1	0.2	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.1	0.9	GO:0043522	leucine zipper domain binding(GO:0043522)
0.1	1.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.3	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0	1.4	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	3.4	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	2.0	GO:0070412	R-SMAD binding(GO:0070412)
0.0	1.9	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.3	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.9	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.7	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	1.3	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.4	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.4	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.0	0.7	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	1.1	GO:0004984	olfactory receptor activity(GO:0004984)
0.0	8.1	GO:0019901	protein kinase binding(GO:0019901)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.0	PID AURORA A PATHWAY	Aurora A signaling
0.1	5.7	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	4.8	PID BMP PATHWAY	BMP receptor signaling
0.1	2.5	PID ALK1 PATHWAY	ALK1 signaling events
0.1	16.1	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.1	4.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	3.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	2.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	2.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	1.0	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.9	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	7.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	0.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.2	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.2	3.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	2.5	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.2	8.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	3.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	2.4	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	2.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.1	3.6	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	1.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.1	1.6	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	1.0	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	1.6	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.1	3.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.1	1.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	3.9	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	2.2	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.1	1.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	1.0	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	2.2	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	3.5	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.4	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	1.7	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	1.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	1.7	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.5	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.4	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	1.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	1.1	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation

Results for SMAD3

Z-value: 2.29

Motif logo

Transcription factors associated with SMAD3

Activity-expression correlation:

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: