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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX11

Z-value: 1.04

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Transcription factors associated with SOX11

Gene Symbol Gene ID Gene Info
SOX11
ENSG00000176887.7 SOX11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX11hg38_v1_chr2_+_5692357_56924100.135.9e-02Click!

Activity profile of SOX11 motif

Sorted Z-values of SOX11 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX11

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr20_+_11892493 10.52 ENST00000422390.5
ENST00000618918.4
BTBD3
BTB domain containing 3
chr15_+_80441229 10.04 ENST00000533983.5
ENST00000527771.5
ENST00000525103.1
ARNT2
aryl hydrocarbon receptor nuclear translocator 2
chr5_+_72107453 7.97 ENST00000296755.12
ENST00000511641.2
MAP1B
microtubule associated protein 1B
chr4_-_89838289 7.14 ENST00000336904.7
SNCA
synuclein alpha
chr13_-_44474296 6.68 ENST00000611198.4
TSC22D1
TSC22 domain family member 1
chr7_-_93890160 6.46 ENST00000451238.1
TFPI2
tissue factor pathway inhibitor 2
chrX_-_13817027 6.42 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
GPM6B
glycoprotein M6B
chr9_-_14300231 5.55 ENST00000636735.1
NFIB
nuclear factor I B
chr17_-_10114546 4.76 ENST00000323816.8
GAS7
growth arrest specific 7
chr8_-_13276491 4.18 ENST00000512044.6
DLC1
DLC1 Rho GTPase activating protein
chr7_+_99325857 4.01 ENST00000638617.1
ENST00000262942.10
ENSG00000284292.1
ARPC1A
novel protein, ARPC1A and ARPC1B readthrough
actin related protein 2/3 complex subunit 1A
chr1_+_204870831 3.43 ENST00000404076.5
ENST00000539706.6
NFASC
neurofascin
chr15_+_83447328 3.28 ENST00000427482.7
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3
chr7_-_83162899 3.21 ENST00000423517.6
PCLO
piccolo presynaptic cytomatrix protein
chr2_+_11534039 3.21 ENST00000381486.7
GREB1
growth regulating estrogen receptor binding 1
chr2_-_224402097 3.11 ENST00000409685.4
FAM124B
family with sequence similarity 124 member B
chr15_+_83447411 3.00 ENST00000324537.5
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3
chr17_-_68955332 2.98 ENST00000269080.6
ENST00000615593.4
ENST00000586539.6
ENST00000430352.6
ABCA8
ATP binding cassette subfamily A member 8
chr2_-_2324323 2.72 ENST00000648339.1
ENST00000647694.1
MYT1L
myelin transcription factor 1 like
chr8_-_53839846 2.64 ENST00000520188.5
ATP6V1H
ATPase H+ transporting V1 subunit H
chr18_+_7754959 2.62 ENST00000400053.8
PTPRM
protein tyrosine phosphatase receptor type M
chr2_-_224401994 2.61 ENST00000389874.3
FAM124B
family with sequence similarity 124 member B
chr5_+_174045673 2.56 ENST00000303177.8
ENST00000519867.5
NSG2
neuronal vesicle trafficking associated 2
chr10_-_93482194 2.50 ENST00000358334.9
ENST00000371488.3
MYOF
myoferlin
chr2_+_137964279 2.49 ENST00000329366.8
HNMT
histamine N-methyltransferase
chr10_-_93482326 2.49 ENST00000359263.9
MYOF
myoferlin
chr13_-_29850605 2.44 ENST00000380680.5
UBL3
ubiquitin like 3
chr5_+_140868945 2.42 ENST00000398640.7
PCDHA11
protocadherin alpha 11
chr2_-_189179754 2.28 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr6_-_47309898 2.11 ENST00000296861.2
TNFRSF21
TNF receptor superfamily member 21
chr5_+_140834230 2.08 ENST00000356878.5
ENST00000525929.2
PCDHA7
protocadherin alpha 7
chr10_-_125816596 2.04 ENST00000368786.5
UROS
uroporphyrinogen III synthase
chr5_+_149141817 2.00 ENST00000504238.5
ABLIM3
actin binding LIM protein family member 3
chr2_+_69013414 1.99 ENST00000681816.1
ENST00000482235.2
ANTXR1
ANTXR cell adhesion molecule 1
chr6_+_30617825 1.98 ENST00000259873.5
MRPS18B
mitochondrial ribosomal protein S18B
chr17_+_6444441 1.89 ENST00000250056.12
ENST00000571373.5
ENST00000570337.6
ENST00000572595.6
ENST00000572447.6
ENST00000576056.5
PIMREG
PICALM interacting mitotic regulator
chr1_+_65264694 1.87 ENST00000263441.11
ENST00000395325.7
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr6_-_11382247 1.83 ENST00000397378.7
ENST00000513989.5
ENST00000508546.5
ENST00000504387.5
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_+_69013379 1.75 ENST00000409349.7
ANTXR1
ANTXR cell adhesion molecule 1
chr1_+_205042960 1.74 ENST00000638378.1
CNTN2
contactin 2
chr15_-_64381431 1.72 ENST00000558008.3
ENST00000300035.9
ENST00000559519.5
ENST00000380258.6
PCLAF
PCNA clamp associated factor
chr16_+_67227105 1.67 ENST00000563953.5
ENST00000304800.14
ENST00000565201.1
TMEM208
transmembrane protein 208
chr5_+_140875299 1.65 ENST00000613593.1
ENST00000398631.3
PCDHA12
protocadherin alpha 12
chr22_-_30246739 1.62 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chr3_-_123980727 1.55 ENST00000620893.4
ROPN1
rhophilin associated tail protein 1
chr15_+_57219411 1.48 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
TCF12
transcription factor 12
chr17_-_81937221 1.48 ENST00000402252.6
ENST00000583564.5
ENST00000585244.1
ENST00000337943.9
ENST00000579698.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr1_-_112935984 1.40 ENST00000443580.6
SLC16A1
solute carrier family 16 member 1
chr18_+_11752041 1.33 ENST00000423027.8
GNAL
G protein subunit alpha L
chr7_-_96709780 1.31 ENST00000623693.3
ENST00000623498.3
ENST00000488005.5
ENST00000413065.5
SEM1
SEM1 26S proteasome complex subunit
chr22_-_28306645 1.28 ENST00000612946.4
TTC28
tetratricopeptide repeat domain 28
chr17_-_36017953 1.28 ENST00000612516.4
ENST00000615050.2
CCL23
C-C motif chemokine ligand 23
chr17_-_81937277 1.27 ENST00000405481.8
ENST00000329875.13
ENST00000585215.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr5_-_160852200 1.22 ENST00000327245.10
ATP10B
ATPase phospholipid transporting 10B (putative)
chr2_+_137964446 1.22 ENST00000280096.5
ENST00000280097.5
HNMT
histamine N-methyltransferase
chr8_+_104339796 1.15 ENST00000622554.1
ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr2_+_73828916 1.15 ENST00000339566.7
ENST00000683349.1
ENST00000682157.1
ENST00000682851.1
ENST00000394070.7
ENST00000409707.6
ENST00000684585.1
ENST00000683434.1
ENST00000682352.1
ENST00000424659.6
ENST00000536064.2
ENST00000684355.1
ENST00000682998.1
ENST00000682799.1
ENST00000394073.6
ENST00000682848.1
ENST00000683877.1
ENST00000682351.1
ENST00000683818.1
ENST00000683391.1
ENST00000682558.1
STAMBP
STAM binding protein
chr3_-_123991352 1.13 ENST00000184183.8
ROPN1
rhophilin associated tail protein 1
chr8_+_9555900 1.12 ENST00000310430.11
ENST00000520408.5
ENST00000522110.1
TNKS
tankyrase
chr1_-_145910031 1.03 ENST00000369304.8
ITGA10
integrin subunit alpha 10
chr17_-_36001549 0.95 ENST00000617897.2
CCL15
C-C motif chemokine ligand 15
chr18_+_58196736 0.94 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr9_-_92404559 0.92 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr15_+_49155750 0.90 ENST00000327171.7
ENST00000560654.5
GALK2
galactokinase 2
chr11_-_118176576 0.90 ENST00000278947.6
SCN2B
sodium voltage-gated channel beta subunit 2
chr14_-_36320582 0.90 ENST00000604336.5
ENST00000359527.11
ENST00000621657.4
ENST00000603139.1
ENST00000318473.11
ENST00000416007.9
MBIP
MAP3K12 binding inhibitory protein 1
chr2_-_175181663 0.88 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP5MC3
ATP synthase membrane subunit c locus 3
chr3_-_125520165 0.86 ENST00000251775.9
SNX4
sorting nexin 4
chr18_+_48539017 0.84 ENST00000256413.8
CTIF
cap binding complex dependent translation initiation factor
chrX_-_21758021 0.83 ENST00000646008.1
SMPX
small muscle protein X-linked
chr2_-_177263522 0.83 ENST00000448782.5
ENST00000446151.6
NFE2L2
nuclear factor, erythroid 2 like 2
chr1_-_145910066 0.80 ENST00000539363.2
ITGA10
integrin subunit alpha 10
chr8_-_85341659 0.79 ENST00000522389.5
CA1
carbonic anhydrase 1
chr21_+_5011799 0.79 ENST00000624081.1
ENSG00000279493.1
novel protein, similar to DNA (cytosine-5-)-methyltransferase 3-like DNMT3L
chr2_+_102311546 0.78 ENST00000233954.6
ENST00000447231.5
IL1RL1
interleukin 1 receptor like 1
chr7_+_70596078 0.78 ENST00000644506.1
AUTS2
activator of transcription and developmental regulator AUTS2
chr11_+_22666604 0.75 ENST00000454584.6
GAS2
growth arrest specific 2
chr4_+_71339014 0.68 ENST00000340595.4
SLC4A4
solute carrier family 4 member 4
chr9_-_21141832 0.68 ENST00000380229.4
IFNW1
interferon omega 1
chr2_+_102311502 0.67 ENST00000404917.6
ENST00000410040.5
IL1RL1
IL18R1
interleukin 1 receptor like 1
interleukin 18 receptor 1
chr8_+_103819244 0.67 ENST00000262231.14
ENST00000507740.5
ENST00000408894.6
RIMS2
regulating synaptic membrane exocytosis 2
chr14_+_102362931 0.65 ENST00000359520.12
TECPR2
tectonin beta-propeller repeat containing 2
chr16_+_482507 0.62 ENST00000412256.1
RAB11FIP3
RAB11 family interacting protein 3
chr12_-_10802627 0.60 ENST00000240687.2
TAS2R7
taste 2 receptor member 7
chr9_+_73151833 0.60 ENST00000456643.5
ENST00000257497.11
ENST00000415424.5
ANXA1
annexin A1
chr10_+_80408485 0.59 ENST00000615554.4
ENST00000372185.5
PRXL2A
peroxiredoxin like 2A
chr6_+_52423680 0.56 ENST00000538167.2
EFHC1
EF-hand domain containing 1
chr6_+_26183750 0.54 ENST00000614097.3
H2BC6
H2B clustered histone 6
chr6_-_11778781 0.54 ENST00000414691.8
ENST00000229583.9
ADTRP
androgen dependent TFPI regulating protein
chr20_-_7940444 0.53 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chrX_+_30243715 0.53 ENST00000378981.8
ENST00000397550.6
MAGEB1
MAGE family member B1
chr5_+_136160986 0.51 ENST00000507637.1
SMAD5
SMAD family member 5
chr6_-_46080332 0.51 ENST00000185206.12
CLIC5
chloride intracellular channel 5
chrX_-_7927701 0.50 ENST00000537427.5
ENST00000444736.5
ENST00000442940.1
PNPLA4
patatin like phospholipase domain containing 4
chr8_+_24384275 0.48 ENST00000256412.8
ADAMDEC1
ADAM like decysin 1
chr20_+_33237712 0.46 ENST00000618484.1
BPIFA1
BPI fold containing family A member 1
chr7_-_122995700 0.46 ENST00000249284.3
TAS2R16
taste 2 receptor member 16
chr11_+_62208665 0.45 ENST00000244930.6
SCGB2A1
secretoglobin family 2A member 1
chr2_+_108621260 0.43 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr8_-_85341705 0.43 ENST00000517618.5
CA1
carbonic anhydrase 1
chr16_+_19067989 0.42 ENST00000569127.1
COQ7
coenzyme Q7, hydroxylase
chr12_-_81369348 0.40 ENST00000548670.1
ENST00000541017.5
ENST00000541570.6
ENST00000553058.5
PPFIA2
PTPRF interacting protein alpha 2
chrX_-_21758097 0.39 ENST00000379494.4
SMPX
small muscle protein X-linked
chr4_-_158159657 0.38 ENST00000590648.5
GASK1B
golgi associated kinase 1B
chr1_-_24143112 0.37 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr7_+_142111739 0.37 ENST00000550469.6
ENST00000477922.3
MGAM2
maltase-glucoamylase 2 (putative)
chr8_-_25424260 0.35 ENST00000421054.7
GNRH1
gonadotropin releasing hormone 1
chr1_-_150697128 0.33 ENST00000427665.1
ENST00000271732.8
GOLPH3L
golgi phosphoprotein 3 like
chr3_-_46085817 0.33 ENST00000683768.1
XCR1
X-C motif chemokine receptor 1
chr1_-_92792396 0.32 ENST00000370331.5
ENST00000540033.2
EVI5
ecotropic viral integration site 5
chr8_-_71361860 0.31 ENST00000303824.11
ENST00000645451.1
EYA1
EYA transcriptional coactivator and phosphatase 1
chr8_-_71362054 0.31 ENST00000340726.8
EYA1
EYA transcriptional coactivator and phosphatase 1
chrX_-_32155462 0.29 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
DMD
dystrophin
chr1_+_50103903 0.27 ENST00000371827.5
ELAVL4
ELAV like RNA binding protein 4
chr18_+_24460655 0.26 ENST00000426880.2
HRH4
histamine receptor H4
chr4_+_168092530 0.25 ENST00000359299.8
ANXA10
annexin A10
chr13_-_98977975 0.24 ENST00000376460.5
DOCK9
dedicator of cytokinesis 9
chr9_+_27109200 0.24 ENST00000380036.10
TEK
TEK receptor tyrosine kinase
chr17_-_10373002 0.22 ENST00000252172.9
ENST00000418404.8
MYH13
myosin heavy chain 13
chr6_-_49636832 0.21 ENST00000371175.10
ENST00000646272.1
ENST00000646939.1
ENST00000618248.3
ENST00000229810.9
ENST00000646963.1
RHAG
Rh associated glycoprotein
chrX_+_102937272 0.21 ENST00000218249.7
RAB40AL
RAB40A like
chr5_+_170353480 0.20 ENST00000377360.8
KCNIP1
potassium voltage-gated channel interacting protein 1
chr8_+_41529212 0.20 ENST00000520710.5
ENST00000518671.5
GINS4
GINS complex subunit 4
chr12_+_50400809 0.18 ENST00000293618.12
ENST00000429001.7
ENST00000398473.7
ENST00000548174.5
ENST00000548697.5
ENST00000548993.5
ENST00000614335.4
ENST00000522085.5
ENST00000615080.4
ENST00000518444.5
ENST00000551886.5
ENST00000523389.5
ENST00000518561.5
ENST00000347328.9
ENST00000550260.1
LARP4
La ribonucleoprotein 4
chr1_-_110519175 0.17 ENST00000369771.4
KCNA10
potassium voltage-gated channel subfamily A member 10
chr20_-_33720221 0.14 ENST00000409299.8
ENST00000217398.3
ENST00000344022.7
PXMP4
peroxisomal membrane protein 4
chr14_+_22524325 0.13 ENST00000390517.1
TRAJ20
T cell receptor alpha joining 20
chr5_+_108747879 0.13 ENST00000281092.9
FER
FER tyrosine kinase
chr8_+_41529242 0.12 ENST00000523277.6
ENST00000276533.4
GINS4
GINS complex subunit 4
chr4_+_87832917 0.12 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr9_+_27109135 0.10 ENST00000519097.5
ENST00000615002.4
TEK
TEK receptor tyrosine kinase
chr11_+_57657736 0.09 ENST00000529773.2
ENST00000533905.1
ENST00000525602.1
ENST00000533682.2
ENST00000302731.4
CLP1
cleavage factor polyribonucleotide kinase subunit 1
chr10_+_116591010 0.09 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr19_+_15728024 0.07 ENST00000305899.5
OR10H2
olfactory receptor family 10 subfamily H member 2
chr14_-_52069039 0.07 ENST00000216286.10
NID2
nidogen 2
chr18_+_24460630 0.05 ENST00000256906.5
HRH4
histamine receptor H4
chr16_+_19067893 0.02 ENST00000544894.6
ENST00000561858.5
COQ7
coenzyme Q7, hydroxylase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
1.1 6.4 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.7 3.7 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.7 2.1 GO:0099526 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.7 2.1 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.6 3.7 GO:0001692 histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.6 1.7 GO:0071206 establishment of protein localization to juxtaparanode region of axon(GO:0071206)
0.5 1.6 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.5 2.0 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.5 5.6 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.5 8.0 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.5 2.3 GO:2000542 negative regulation of gastrulation(GO:2000542)
0.4 1.2 GO:0034239 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.4 3.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.4 1.1 GO:0099403 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) protein auto-ADP-ribosylation(GO:0070213) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of telomeric DNA binding(GO:1904742) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.3 2.7 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.3 5.0 GO:0001778 plasma membrane repair(GO:0001778)
0.3 0.9 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.3 4.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.3 0.8 GO:0098582 innate vocalization behavior(GO:0098582)
0.2 3.0 GO:0042908 xenobiotic transport(GO:0042908)
0.2 0.8 GO:0043387 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.2 1.5 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 6.5 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.2 1.4 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.2 0.6 GO:0036292 positive regulation of prostaglandin biosynthetic process(GO:0031394) DNA rewinding(GO:0036292) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.2 1.9 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.2 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1 0.5 GO:1900228 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.1 0.9 GO:0046684 response to pyrethroid(GO:0046684)
0.1 0.5 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 0.9 GO:0043545 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 2.6 GO:0010842 retina layer formation(GO:0010842)
0.1 4.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.3 GO:2000354 response to prolactin(GO:1990637) regulation of ovarian follicle development(GO:2000354)
0.1 3.3 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.9 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 2.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 2.6 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.1 0.6 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 0.7 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.5 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 10.0 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 11.1 GO:0021987 cerebral cortex development(GO:0021987)
0.1 0.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.2 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 0.9 GO:0006012 galactose metabolic process(GO:0006012)
0.0 1.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.3 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 2.2 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 6.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.7 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0050904 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 1.7 GO:0019985 translesion synthesis(GO:0019985)
0.0 2.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 2.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.8 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 4.9 GO:0007050 cell cycle arrest(GO:0007050)
0.0 1.5 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0005588 collagen type V trimer(GO:0005588)
0.7 2.1 GO:0098831 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569)
0.7 3.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.7 2.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.4 1.8 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.3 5.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 1.2 GO:0005927 muscle tendon junction(GO:0005927)
0.2 4.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 7.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 10.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 4.0 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.6 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.1 2.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 8.7 GO:0005901 caveola(GO:0005901)
0.1 6.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 4.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 6.6 GO:0030027 lamellipodium(GO:0030027)
0.0 11.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.9 GO:0005771 multivesicular body(GO:0005771)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 8.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 1.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.4 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.7 10.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.5 2.0 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.5 1.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.5 2.7 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 0.9 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.3 3.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.3 1.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 3.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 2.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 1.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 0.5 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.2 0.9 GO:1990460 leptin receptor binding(GO:1990460)
0.1 1.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.4 GO:0004339 glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.1 1.2 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 2.1 GO:0005522 profilin binding(GO:0005522)
0.1 2.6 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 8.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.5 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 4.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.9 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.7 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.5 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 3.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 3.7 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 8.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 10.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 1.6 GO:0043621 protein self-association(GO:0043621)
0.0 0.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 4.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 0.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0000146 microfilament motor activity(GO:0000146)
0.0 2.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 3.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 5.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 1.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 5.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 4.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 3.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.5 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.9 ST ADRENERGIC Adrenergic Pathway
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.9 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 6.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 1.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 4.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.9 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 2.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins