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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX14

Z-value: 6.68

Motif logo

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Transcription factors associated with SOX14

Gene Symbol Gene ID Gene Info
SOX14
ENSG00000168875.3 SOX14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX14hg38_v1_chr3_+_137764296_137764320-0.606.0e-23Click!

Activity profile of SOX14 motif

Sorted Z-values of SOX14 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX14

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_25906457 49.96 ENST00000426559.6
STMN1
stathmin 1
chr6_-_85644043 40.89 ENST00000678930.1
ENST00000678355.1
SYNCRIP
synaptotagmin binding cytoplasmic RNA interacting protein
chr17_-_8210565 35.36 ENST00000577833.5
ENST00000585124.6
ENST00000534871.5
ENST00000583915.1
ENST00000316199.10
ENST00000581511.5
AURKB
aurora kinase B
chr17_-_8210203 32.44 ENST00000578549.5
ENST00000582368.5
AURKB
aurora kinase B
chr6_-_85643832 32.03 ENST00000677771.1
ENST00000676688.1
SYNCRIP
synaptotagmin binding cytoplasmic RNA interacting protein
chr12_-_57752265 27.76 ENST00000547281.5
ENST00000257904.11
ENST00000546489.5
ENST00000552388.1
CDK4
cyclin dependent kinase 4
chr13_-_23433676 27.37 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
SACS
sacsin molecular chaperone
chr6_-_85643778 26.87 ENST00000676637.1
ENST00000678528.1
SYNCRIP
synaptotagmin binding cytoplasmic RNA interacting protein
chr12_-_57752345 26.50 ENST00000551800.5
ENST00000549606.5
ENST00000312990.10
CDK4
cyclin dependent kinase 4
chr19_+_16076485 26.37 ENST00000643579.2
ENST00000646575.1
TPM4
tropomyosin 4
chr19_+_16077006 24.06 ENST00000586833.7
ENST00000642221.1
TPM4
tropomyosin 4
chr1_-_225428813 23.99 ENST00000338179.6
ENST00000425080.1
LBR
lamin B receptor
chr12_+_68610858 20.19 ENST00000393436.9
ENST00000425247.6
ENST00000250559.14
ENST00000489473.6
ENST00000422358.6
ENST00000541167.5
ENST00000538283.5
ENST00000341355.9
ENST00000537460.5
ENST00000450214.6
ENST00000545270.5
RAP1B
RAP1B, member of RAS oncogene family
chr2_-_160493799 19.67 ENST00000348849.8
RBMS1
RNA binding motif single stranded interacting protein 1
chr10_-_13348270 18.16 ENST00000378614.8
ENST00000327347.10
ENST00000545675.5
SEPHS1
selenophosphate synthetase 1
chr2_-_37672448 18.10 ENST00000611976.1
CDC42EP3
CDC42 effector protein 3
chr3_-_182980531 18.07 ENST00000292782.9
ENST00000632685.1
DCUN1D1
defective in cullin neddylation 1 domain containing 1
chr1_+_51617079 18.02 ENST00000447887.5
ENST00000428468.6
ENST00000453295.5
OSBPL9
oxysterol binding protein like 9
chr12_+_69239592 17.67 ENST00000456847.7
ENST00000266679.8
CPSF6
cleavage and polyadenylation specific factor 6
chr11_-_102452758 17.55 ENST00000398136.7
ENST00000361236.7
TMEM123
transmembrane protein 123
chr11_+_4094775 17.46 ENST00000300738.10
RRM1
ribonucleotide reductase catalytic subunit M1
chr18_+_3447562 17.09 ENST00000618001.4
TGIF1
TGFB induced factor homeobox 1
chr13_-_23433735 16.64 ENST00000423156.2
ENST00000683210.1
ENST00000682775.1
ENST00000684497.1
ENST00000682944.1
ENST00000683489.1
ENST00000684385.1
ENST00000683680.1
SACS
sacsin molecular chaperone
chr6_+_30720335 16.20 ENST00000327892.13
TUBB
tubulin beta class I
chr7_-_106285898 16.10 ENST00000424768.2
ENST00000681255.1
NAMPT
nicotinamide phosphoribosyltransferase
chr2_+_186506713 15.16 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chrX_+_12975216 14.92 ENST00000380635.5
TMSB4X
thymosin beta 4 X-linked
chr2_-_37671633 14.63 ENST00000295324.4
CDC42EP3
CDC42 effector protein 3
chr12_-_49187369 14.28 ENST00000547939.6
TUBA1A
tubulin alpha 1a
chr5_-_179623098 13.98 ENST00000630639.1
ENST00000329433.10
ENST00000510411.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chrX_-_15854743 13.96 ENST00000450644.2
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr2_-_9630946 13.78 ENST00000446619.1
ENST00000238081.8
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
chr2_-_9630491 13.77 ENST00000381844.8
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
chr8_-_80080816 13.67 ENST00000520527.5
ENST00000517427.5
ENST00000379097.7
ENST00000448733.3
TPD52
tumor protein D52
chr12_+_69239627 13.61 ENST00000551516.1
CPSF6
cleavage and polyadenylation specific factor 6
chr14_-_34875348 13.40 ENST00000360310.6
BAZ1A
bromodomain adjacent to zinc finger domain 1A
chr6_+_113857333 13.35 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr2_-_105398978 12.97 ENST00000408995.5
ENST00000530340.6
ENST00000393353.7
ENST00000322142.13
ENST00000344213.9
ENST00000358129.8
FHL2
four and a half LIM domains 2
chr10_+_22321056 12.04 ENST00000376663.8
BMI1
BMI1 proto-oncogene, polycomb ring finger
chr1_-_25906411 11.98 ENST00000455785.7
STMN1
stathmin 1
chr6_+_32969345 11.65 ENST00000678250.1
BRD2
bromodomain containing 2
chrX_+_101390824 11.62 ENST00000427805.6
ENST00000614077.4
RPL36A
ribosomal protein L36a
chr6_-_31730198 11.53 ENST00000375787.6
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr6_-_31541937 11.41 ENST00000456662.5
ENST00000431908.5
ENST00000456976.5
ENST00000428450.5
ENST00000418897.5
ENST00000396172.6
ENST00000419020.1
ENST00000428098.5
DDX39B
DExD-box helicase 39B
chr7_-_106285094 11.39 ENST00000680584.1
ENST00000354289.9
NAMPT
nicotinamide phosphoribosyltransferase
chr1_+_226062704 11.30 ENST00000366814.3
ENST00000366815.10
ENST00000655399.1
ENST00000667897.1
H3-3A
H3.3 histone A
chr2_-_37672178 11.18 ENST00000457889.1
CDC42EP3
CDC42 effector protein 3
chr17_-_81514629 10.94 ENST00000681052.1
ENST00000575659.6
ACTG1
actin gamma 1
chr18_+_3448456 10.86 ENST00000549780.5
TGIF1
TGFB induced factor homeobox 1
chr6_+_32969165 10.58 ENST00000496118.2
ENST00000449085.4
BRD2
bromodomain containing 2
chr17_-_54968637 10.37 ENST00000299335.8
COX11
cytochrome c oxidase copper chaperone COX11
chrX_+_101390976 10.31 ENST00000392994.7
RPL36A
ribosomal protein L36a
chr12_-_15789375 10.08 ENST00000544064.1
ENST00000642939.1
ENST00000281172.10
ENST00000543523.5
ENST00000644374.1
ENST00000645775.1
ENST00000642278.1
ENST00000646123.1
ENST00000536793.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr1_+_93079264 9.69 ENST00000370298.9
ENST00000370303.4
MTF2
metal response element binding transcription factor 2
chr11_+_10751203 9.69 ENST00000361367.7
CTR9
CTR9 homolog, Paf1/RNA polymerase II complex component
chr14_+_69611586 9.69 ENST00000342745.5
SUSD6
sushi domain containing 6
chrX_+_101391000 9.65 ENST00000553110.8
ENST00000409338.5
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr6_+_137867414 9.57 ENST00000237289.8
ENST00000433680.1
TNFAIP3
TNF alpha induced protein 3
chr4_-_102345469 9.47 ENST00000356736.5
ENST00000682932.1
SLC39A8
solute carrier family 39 member 8
chrX_+_101391202 9.41 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr11_+_66480425 9.06 ENST00000541961.5
ENST00000532019.5
ENST00000526515.5
ENST00000530165.5
ENST00000533725.5
DPP3
dipeptidyl peptidase 3
chr3_-_120450981 9.04 ENST00000424703.6
ENST00000469005.1
ENST00000295633.8
FSTL1
follistatin like 1
chr14_-_34874887 8.60 ENST00000382422.6
BAZ1A
bromodomain adjacent to zinc finger domain 1A
chr4_-_1248976 8.56 ENST00000514210.5
ENST00000382952.8
ENST00000290921.10
CTBP1
C-terminal binding protein 1
chr7_+_44797114 8.40 ENST00000677022.1
PPIA
peptidylprolyl isomerase A
chr11_+_63986821 8.32 ENST00000543988.1
OTUB1
OTU deubiquitinase, ubiquitin aldehyde binding 1
chr1_+_93079234 8.18 ENST00000540243.5
ENST00000545708.5
MTF2
metal response element binding transcription factor 2
chr2_+_191245185 8.01 ENST00000418908.5
ENST00000339514.8
ENST00000392318.8
MYO1B
myosin IB
chr1_-_211579064 7.97 ENST00000367001.5
SLC30A1
solute carrier family 30 member 1
chr6_-_24877262 7.95 ENST00000378023.8
ENST00000540914.5
RIPOR2
RHO family interacting cell polarization regulator 2
chr15_-_83067199 7.83 ENST00000261721.9
BTBD1
BTB domain containing 1
chr12_-_122500947 7.76 ENST00000672018.1
ZCCHC8
zinc finger CCHC-type containing 8
chr7_-_108003122 7.71 ENST00000393559.2
ENST00000222399.11
ENST00000676777.1
ENST00000439976.6
ENST00000393560.5
ENST00000677793.1
ENST00000679244.1
LAMB1
laminin subunit beta 1
chrX_-_15854791 7.67 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
AP1S2
adaptor related protein complex 1 subunit sigma 2
chrX_+_12975083 7.54 ENST00000451311.7
ENST00000380636.1
TMSB4X
thymosin beta 4 X-linked
chr3_-_57597325 7.34 ENST00000496292.5
ENST00000489843.1
ENST00000303436.11
ARF4
ADP ribosylation factor 4
chrX_-_38220824 7.26 ENST00000378533.4
ENST00000432886.6
ENST00000544439.5
ENST00000538295.5
SRPX
sushi repeat containing protein X-linked
chr5_-_177409535 7.13 ENST00000253496.4
F12
coagulation factor XII
chr3_-_47443092 7.05 ENST00000545718.2
ENST00000495603.2
SCAP
SREBF chaperone
chr2_+_101697699 6.62 ENST00000350878.8
ENST00000350198.8
ENST00000324219.8
ENST00000425019.5
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr4_-_75673360 6.55 ENST00000676584.1
ENST00000678329.1
ENST00000677889.1
ENST00000357854.7
ENST00000359707.9
ENST00000676974.1
ENST00000678273.1
ENST00000677201.1
ENST00000678244.1
ENST00000677125.1
ENST00000677162.1
G3BP2
G3BP stress granule assembly factor 2
chr11_-_10808913 6.38 ENST00000527419.6
ENST00000530211.6
ENST00000339995.11
ENST00000530702.2
ENST00000524932.6
ENST00000532570.6
EIF4G2
eukaryotic translation initiation factor 4 gamma 2
chrX_+_71283577 6.23 ENST00000420903.6
ENST00000373856.8
ENST00000678437.1
ENST00000678830.1
ENST00000677879.1
ENST00000373841.5
ENST00000276079.13
ENST00000676797.1
ENST00000678660.1
ENST00000678231.1
ENST00000677612.1
ENST00000413858.5
ENST00000450092.6
NONO
non-POU domain containing octamer binding
chr1_+_23959797 6.13 ENST00000374468.1
ENST00000334351.8
PNRC2
proline rich nuclear receptor coactivator 2
chr12_-_389249 6.06 ENST00000535014.5
ENST00000543507.1
ENST00000544760.1
ENST00000399788.7
KDM5A
lysine demethylase 5A
chr8_+_132775340 5.95 ENST00000622263.4
ENST00000220847.8
ENST00000395379.5
ENST00000395386.7
ENST00000485595.5
ENST00000337920.8
PHF20L1
PHD finger protein 20 like 1
chr2_+_169733811 5.81 ENST00000392647.7
KLHL23
kelch like family member 23
chr15_+_64095967 5.45 ENST00000559844.6
ENST00000261889.9
ENST00000625244.2
ENST00000561026.5
ENST00000558040.5
SNX1
sorting nexin 1
chr5_-_134174765 5.44 ENST00000520417.1
SKP1
S-phase kinase associated protein 1
chr17_+_28744034 5.42 ENST00000444415.7
ENST00000262396.10
TRAF4
TNF receptor associated factor 4
chr2_+_9206762 5.31 ENST00000315273.4
ENST00000281419.8
ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr6_-_159726871 5.20 ENST00000535561.5
SOD2
superoxide dismutase 2
chr12_-_24902243 5.15 ENST00000538118.5
BCAT1
branched chain amino acid transaminase 1
chr3_-_57597443 5.00 ENST00000463880.1
ARF4
ADP ribosylation factor 4
chr1_-_25905989 4.94 ENST00000399728.5
STMN1
stathmin 1
chr1_+_24745396 4.82 ENST00000374379.9
CLIC4
chloride intracellular channel 4
chrX_-_3713593 4.66 ENST00000262848.6
PRKX
protein kinase X-linked
chr5_-_177473609 4.64 ENST00000477391.6
ENST00000393565.5
ENST00000309007.9
DBN1
drebrin 1
chr12_-_122422662 4.47 ENST00000620786.5
CLIP1
CAP-Gly domain containing linker protein 1
chr16_+_21599558 4.38 ENST00000396014.8
ENST00000358154.8
ENST00000615720.4
METTL9
methyltransferase like 9
chr10_+_6202866 4.29 ENST00000317350.8
ENST00000379785.5
ENST00000625260.2
ENST00000626882.2
ENST00000360521.7
ENST00000379775.9
ENST00000640683.1
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr7_-_24757413 4.18 ENST00000645220.1
ENST00000409970.6
GSDME
gasdermin E
chr11_-_47553117 4.17 ENST00000310513.10
ENST00000531165.5
CELF1
CUGBP Elav-like family member 1
chr10_-_32958164 3.98 ENST00000414670.2
ENST00000677363.1
ENST00000474568.6
ENST00000678591.1
ENST00000678943.1
ENST00000488494.6
ENST00000488427.2
ENST00000302278.8
ENST00000676964.1
ENST00000679187.1
ENST00000678952.1
ENST00000677999.1
ENST00000609742.3
ENST00000678766.1
ENST00000676460.1
ENST00000676659.1
ENST00000417122.7
ENST00000677310.1
ITGB1
integrin subunit beta 1
chr22_-_38317423 3.97 ENST00000396832.6
ENST00000403904.5
ENST00000405675.7
CSNK1E
casein kinase 1 epsilon
chrX_+_11760035 3.96 ENST00000482871.6
ENST00000648013.1
MSL3
MSL complex subunit 3
chr11_-_36289408 3.68 ENST00000263401.10
ENST00000532705.1
ENST00000452374.6
COMMD9
COMM domain containing 9
chr10_+_10798570 3.65 ENST00000638035.1
ENST00000636488.1
CELF2
CUGBP Elav-like family member 2
chr10_+_80454274 3.44 ENST00000372158.6
ENST00000372157.6
ENST00000372164.7
ENST00000341863.10
TSPAN14
tetraspanin 14
chrX_+_11760087 3.24 ENST00000649271.1
MSL3
MSL complex subunit 3
chr11_+_60924452 3.20 ENST00000453848.7
ENST00000544065.5
ENST00000005286.8
TMEM132A
transmembrane protein 132A
chrX_+_108044967 3.18 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_102724781 2.99 ENST00000438475.2
MMP8
matrix metallopeptidase 8
chr1_+_23019415 2.98 ENST00000465864.2
ENST00000356634.7
ENST00000400181.9
KDM1A
lysine demethylase 1A
chr13_+_111115303 2.93 ENST00000646102.2
ENST00000449979.5
ARHGEF7
Rho guanine nucleotide exchange factor 7
chr5_-_147453888 2.86 ENST00000398514.7
DPYSL3
dihydropyrimidinase like 3
chr19_+_48965304 2.65 ENST00000331825.11
FTL
ferritin light chain
chr5_+_87267792 2.52 ENST00000274376.11
RASA1
RAS p21 protein activator 1
chr6_+_159761991 2.38 ENST00000367048.5
ACAT2
acetyl-CoA acetyltransferase 2
chr7_+_26152188 2.37 ENST00000056233.4
NFE2L3
nuclear factor, erythroid 2 like 3
chr11_-_62646598 2.30 ENST00000648273.1
ENST00000356638.8
ENST00000346178.8
ENST00000534779.5
ENST00000525994.1
ENST00000540933.5
GANAB
glucosidase II alpha subunit
chr5_-_179623659 2.23 ENST00000519056.5
ENST00000506721.5
ENST00000503105.5
ENST00000504348.5
ENST00000508103.5
ENST00000510431.5
ENST00000515158.5
ENST00000393432.8
ENST00000442819.6
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr7_+_102285125 2.16 ENST00000536178.3
SH2B2
SH2B adaptor protein 2
chr19_-_51387955 2.09 ENST00000221973.7
ENST00000596399.2
LIM2
lens intrinsic membrane protein 2
chrX_+_108045050 2.02 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr14_-_21526391 2.01 ENST00000611430.4
SALL2
spalt like transcription factor 2
chr8_+_94641074 1.97 ENST00000423620.6
ESRP1
epithelial splicing regulatory protein 1
chr16_-_75495396 1.97 ENST00000332272.9
CHST6
carbohydrate sulfotransferase 6
chr11_-_70661762 1.94 ENST00000357171.7
ENST00000412252.5
ENST00000449833.6
ENST00000338508.8
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr12_-_85836372 1.90 ENST00000361228.5
RASSF9
Ras association domain family member 9
chr11_-_79441016 1.89 ENST00000278550.12
TENM4
teneurin transmembrane protein 4
chr17_+_28744002 1.87 ENST00000618771.1
ENST00000262395.10
ENST00000422344.5
TRAF4
TNF receptor associated factor 4
chr19_-_17264732 1.85 ENST00000252597.8
USHBP1
USH1 protein network component harmonin binding protein 1
chr1_-_20786610 1.80 ENST00000375000.5
ENST00000312239.10
ENST00000419490.5
ENST00000414993.1
ENST00000443615.1
HP1BP3
heterochromatin protein 1 binding protein 3
chr16_+_3654683 1.79 ENST00000246949.10
DNASE1
deoxyribonuclease 1
chr13_-_78603539 1.76 ENST00000377208.7
POU4F1
POU class 4 homeobox 1
chrX_+_130339941 1.76 ENST00000218197.9
SLC25A14
solute carrier family 25 member 14
chr18_+_58196736 1.71 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr12_-_122422544 1.66 ENST00000358808.6
ENST00000361654.8
ENST00000539080.1
ENST00000537178.5
CLIP1
CAP-Gly domain containing linker protein 1
chrX_-_54496212 1.62 ENST00000375135.4
FGD1
FYVE, RhoGEF and PH domain containing 1
chr20_-_46363174 1.61 ENST00000372227.5
SLC35C2
solute carrier family 35 member C2
chr14_-_91510144 1.60 ENST00000554684.5
ENST00000554511.1
ENST00000554943.6
PPP4R3A
protein phosphatase 4 regulatory subunit 3A
chr1_+_103750406 1.46 ENST00000370079.3
AMY1C
amylase alpha 1C
chr1_+_32465046 1.34 ENST00000609129.2
ZBTB8B
zinc finger and BTB domain containing 8B
chr3_-_27484374 1.31 ENST00000445684.5
ENST00000425128.6
SLC4A7
solute carrier family 4 member 7
chr2_-_144516397 1.26 ENST00000638128.1
ZEB2
zinc finger E-box binding homeobox 2
chr20_-_62065834 1.26 ENST00000252996.9
TAF4
TATA-box binding protein associated factor 4
chr15_+_85380565 1.23 ENST00000559362.5
ENST00000394518.7
AKAP13
A-kinase anchoring protein 13
chr22_+_23180365 1.18 ENST00000359540.7
ENST00000305877.13
BCR
BCR activator of RhoGEF and GTPase
chr2_+_126656128 1.17 ENST00000259254.9
ENST00000409836.3
ENST00000356887.12
GYPC
glycophorin C (Gerbich blood group)
chr1_+_103655760 1.16 ENST00000370083.9
AMY1A
amylase alpha 1A
chr2_-_144516154 1.06 ENST00000637304.1
ZEB2
zinc finger E-box binding homeobox 2
chr16_-_8868994 1.05 ENST00000311052.10
ENST00000565287.5
ENST00000611932.4
CARHSP1
calcium regulated heat stable protein 1
chrX_-_16712572 1.03 ENST00000359276.9
CTPS2
CTP synthase 2
chr3_-_134250831 0.93 ENST00000623711.4
RYK
receptor like tyrosine kinase
chr20_-_44521989 0.86 ENST00000342374.5
ENST00000255175.5
SERINC3
serine incorporator 3
chr4_+_87975667 0.75 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
SPP1
secreted phosphoprotein 1
chr2_-_121649431 0.74 ENST00000455322.6
ENST00000409078.8
ENST00000263710.8
ENST00000397587.7
ENST00000541377.5
CLASP1
cytoplasmic linker associated protein 1
chr2_+_235669602 0.71 ENST00000409538.5
AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chrX_+_103918872 0.70 ENST00000419165.5
TMSB15B
thymosin beta 15B
chr11_+_63986411 0.65 ENST00000538426.6
ENST00000543004.5
OTUB1
OTU deubiquitinase, ubiquitin aldehyde binding 1
chr2_+_64988469 0.65 ENST00000531327.5
SLC1A4
solute carrier family 1 member 4
chr1_+_65992389 0.57 ENST00000423207.6
PDE4B
phosphodiesterase 4B
chrX_-_24672654 0.53 ENST00000379145.5
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr12_-_8662808 0.52 ENST00000359478.7
ENST00000396549.6
MFAP5
microfibril associated protein 5
chr17_+_70104848 0.51 ENST00000392670.5
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr17_-_10036741 0.40 ENST00000585266.5
GAS7
growth arrest specific 7
chr5_+_95731300 0.35 ENST00000379982.8
RHOBTB3
Rho related BTB domain containing 3
chr13_-_98977975 0.27 ENST00000376460.5
DOCK9
dedicator of cytokinesis 9
chr19_-_55141889 0.25 ENST00000593194.5
TNNT1
troponin T1, slow skeletal type
chr11_-_70662197 0.21 ENST00000409161.5
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_+_215082731 0.21 ENST00000444842.7
KCNK2
potassium two pore domain channel subfamily K member 2
chr6_+_30880780 0.12 ENST00000460944.6
ENST00000324771.12
DDR1
discoidin domain receptor tyrosine kinase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
22.6 67.8 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
10.9 54.3 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
7.1 99.8 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
6.2 74.8 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
4.5 17.9 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
3.2 13.0 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
3.2 9.7 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
3.2 9.6 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
3.0 3.0 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
2.9 43.9 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
2.8 22.5 GO:2000483 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) negative regulation of interleukin-8 secretion(GO:2000483)
2.5 10.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
2.4 44.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
2.3 18.2 GO:0001887 selenium compound metabolic process(GO:0001887)
2.1 8.6 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
2.0 6.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
1.9 17.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
1.8 7.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
1.6 27.5 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
1.5 6.1 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
1.4 12.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
1.3 9.0 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.3 17.6 GO:0045793 positive regulation of cell size(GO:0045793)
1.2 12.0 GO:0007379 segment specification(GO:0007379)
1.2 7.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
1.1 11.4 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
1.1 18.1 GO:0045116 protein neddylation(GO:0045116)
1.0 5.2 GO:0003069 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
1.0 5.2 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
1.0 6.1 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.9 20.2 GO:0032486 Rap protein signal transduction(GO:0032486)
0.9 1.8 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.8 8.4 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.8 7.3 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.8 4.0 GO:0010710 regulation of collagen catabolic process(GO:0010710)
0.8 4.6 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.7 17.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.7 6.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.7 6.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.7 5.4 GO:0010265 SCF complex assembly(GO:0010265)
0.7 16.2 GO:0051764 actin crosslink formation(GO:0051764)
0.6 1.9 GO:0032289 central nervous system myelin formation(GO:0032289)
0.6 4.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.6 11.5 GO:0006527 arginine catabolic process(GO:0006527)
0.5 42.7 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.5 27.5 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.5 4.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.5 7.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.4 6.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.4 26.9 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.4 41.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 5.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.4 18.2 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.4 2.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.4 16.8 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.3 6.6 GO:0030033 microvillus assembly(GO:0030033)
0.3 1.2 GO:0060313 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of respiratory burst(GO:0060268) negative regulation of blood vessel remodeling(GO:0060313)
0.3 2.3 GO:1902748 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.3 7.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 2.9 GO:1904424 regulation of GTP binding(GO:1904424)
0.3 1.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.2 0.7 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2 4.0 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.2 5.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 0.9 GO:0036518 chemorepulsion of dopaminergic neuron axon(GO:0036518) chemorepulsion of axon(GO:0061643)
0.2 24.0 GO:0006334 nucleosome assembly(GO:0006334)
0.2 16.2 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 7.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 8.4 GO:0035987 endodermal cell differentiation(GO:0035987)
0.2 1.6 GO:0036066 pyrimidine nucleotide-sugar transport(GO:0015781) protein O-linked fucosylation(GO:0036066)
0.2 10.9 GO:0001895 retina homeostasis(GO:0001895)
0.2 4.7 GO:2000696 regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.1 1.7 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.6 GO:0015808 L-alanine transport(GO:0015808)
0.1 22.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.1 13.7 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 0.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.9 GO:0009597 detection of virus(GO:0009597)
0.1 13.7 GO:0030183 B cell differentiation(GO:0030183)
0.1 2.0 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 14.3 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.1 6.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 17.4 GO:0006260 DNA replication(GO:0006260)
0.1 2.5 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.1 2.1 GO:0060292 long term synaptic depression(GO:0060292)
0.1 9.0 GO:0042594 response to starvation(GO:0042594)
0.1 8.6 GO:0030048 actin filament-based movement(GO:0030048)
0.0 3.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.5 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.6 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 7.5 GO:0043393 regulation of protein binding(GO:0043393)
0.0 19.2 GO:0042493 response to drug(GO:0042493)
0.0 0.2 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 4.3 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 1.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 1.1 GO:0006308 DNA catabolic process(GO:0006308)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0097435 fibril organization(GO:0097435)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.0 15.2 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 7.0 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 99.8 GO:0097452 GAIT complex(GO:0097452)
9.0 54.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
7.5 67.8 GO:0032133 chromosome passenger complex(GO:0032133)
7.3 22.0 GO:0008623 CHRAC(GO:0008623)
4.4 44.0 GO:0070852 cell body fiber(GO:0070852)
4.4 17.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
3.8 34.6 GO:0042382 paraspeckles(GO:0042382)
3.2 45.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
2.6 7.7 GO:0005606 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
1.3 4.0 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
1.1 24.0 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.9 5.4 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.9 7.2 GO:0072487 MSL complex(GO:0072487)
0.9 13.3 GO:0043073 germ cell nucleus(GO:0043073)
0.9 9.7 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.9 11.4 GO:0005688 U6 snRNP(GO:0005688)
0.9 6.1 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.9 16.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.8 5.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.8 12.0 GO:0035102 PRC1 complex(GO:0035102)
0.7 16.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.7 7.9 GO:0060171 stereocilium membrane(GO:0060171)
0.7 10.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 6.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.7 2.6 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.5 7.2 GO:0097433 dense body(GO:0097433)
0.4 41.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 2.9 GO:0000322 storage vacuole(GO:0000322)
0.4 6.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 3.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 21.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.3 20.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 13.0 GO:0031430 M band(GO:0031430)
0.2 22.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 15.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 24.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 1.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.2 7.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 18.0 GO:0031902 late endosome membrane(GO:0031902)
0.1 4.6 GO:0005921 gap junction(GO:0005921)
0.1 2.1 GO:0005883 neurofilament(GO:0005883)
0.1 2.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 53.3 GO:0005874 microtubule(GO:0005874)
0.1 1.8 GO:0000786 nucleosome(GO:0000786)
0.1 7.3 GO:0005776 autophagosome(GO:0005776)
0.1 7.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.1 GO:0043186 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 8.0 GO:0030315 T-tubule(GO:0030315)
0.1 2.9 GO:0031941 filamentous actin(GO:0031941)
0.1 36.3 GO:0016607 nuclear speck(GO:0016607)
0.1 1.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 5.0 GO:0016459 myosin complex(GO:0016459)
0.1 3.0 GO:1990391 DNA repair complex(GO:1990391)
0.1 6.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 11.4 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 4.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 5.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 15.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 1.2 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 5.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 20.8 GO:0005925 focal adhesion(GO:0005925)
0.0 4.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 2.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 6.5 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.6 43.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
8.0 24.0 GO:0050613 delta14-sterol reductase activity(GO:0050613)
7.5 67.8 GO:0035174 histone serine kinase activity(GO:0035174)
5.5 27.5 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
4.4 17.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.6 99.8 GO:0008143 poly(A) binding(GO:0008143)
1.7 12.0 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
1.6 11.5 GO:0016403 dimethylargininase activity(GO:0016403)
1.6 44.0 GO:0070628 proteasome binding(GO:0070628)
1.5 9.0 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
1.4 54.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.3 11.4 GO:0030621 U4 snRNA binding(GO:0030621)
1.2 23.5 GO:0097602 cullin family protein binding(GO:0097602)
1.2 8.6 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.1 5.5 GO:1990460 leptin receptor binding(GO:1990460)
1.0 5.2 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
1.0 9.0 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.9 28.0 GO:0070410 co-SMAD binding(GO:0070410)
0.9 16.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.9 35.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.8 17.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.8 6.6 GO:0004111 creatine kinase activity(GO:0004111)
0.7 9.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.7 4.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.6 16.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.6 8.4 GO:0046790 virion binding(GO:0046790)
0.6 2.4 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.6 22.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.5 23.2 GO:0003785 actin monomer binding(GO:0003785)
0.5 5.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 4.0 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.5 45.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 7.3 GO:0031996 thioesterase binding(GO:0031996)
0.4 1.2 GO:0004556 alpha-amylase activity(GO:0004556)
0.4 9.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.4 1.8 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.4 25.1 GO:0035064 methylated histone binding(GO:0035064)
0.3 9.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 8.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 7.1 GO:0051787 misfolded protein binding(GO:0051787)
0.3 22.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.3 11.6 GO:0015248 sterol transporter activity(GO:0015248)
0.3 2.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.3 2.3 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 2.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 2.0 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.3 6.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 4.6 GO:0005522 profilin binding(GO:0005522)
0.3 2.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.3 2.6 GO:0008199 ferric iron binding(GO:0008199)
0.3 1.0 GO:0003883 CTP synthase activity(GO:0003883)
0.3 20.2 GO:0019003 GDP binding(GO:0019003)
0.2 13.0 GO:0050681 androgen receptor binding(GO:0050681)
0.2 12.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 13.3 GO:0005080 protein kinase C binding(GO:0005080)
0.2 4.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.2 6.1 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 41.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 6.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.2 7.1 GO:0015485 cholesterol binding(GO:0015485)
0.2 1.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 7.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 21.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 10.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.9 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 0.6 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1 46.9 GO:0015631 tubulin binding(GO:0015631)
0.1 0.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 14.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 4.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.9 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 6.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0031491 nucleosome binding(GO:0031491)
0.1 5.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 15.9 GO:0005525 GTP binding(GO:0005525)
0.0 2.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 12.5 GO:0045296 cadherin binding(GO:0045296)
0.0 11.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 6.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 14.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.3 GO:0003924 GTPase activity(GO:0003924)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.9 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 65.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
2.9 54.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.3 72.9 PID AURORA A PATHWAY Aurora A signaling
0.7 27.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.5 10.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 20.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.4 7.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 43.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 9.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.3 29.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 5.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 15.2 PID TNF PATHWAY TNF receptor signaling pathway
0.2 6.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 14.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 10.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 17.5 PID E2F PATHWAY E2F transcription factor network
0.2 22.4 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.2 4.0 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 17.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.2 PID FOXO PATHWAY FoxO family signaling
0.1 1.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 6.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 7.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 5.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 1.8 PID INSULIN PATHWAY Insulin Pathway
0.1 4.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 21.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.5 54.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
1.4 8.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
1.1 13.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
1.0 17.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.8 29.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.8 43.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.8 20.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.7 67.8 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.6 28.0 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.6 5.4 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.6 24.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.6 18.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 35.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 4.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.3 9.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 7.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 41.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 16.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 9.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 5.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 20.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 2.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 2.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 4.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 8.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 6.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 6.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.0 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.5 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing