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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX6

Z-value: 1.23

Motif logo

Transcription factors associated with SOX6

Gene Symbol Gene ID Gene Info
ENSG00000110693.19 SOX6

Activity profile of SOX6 motif

Sorted Z-values of SOX6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX6

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr12_+_6226136 14.96 ENST00000676764.1
ENST00000646407.1
CD9 molecule
chr6_-_106974721 13.26 ENST00000606017.2
ENST00000620405.1
CD24 molecule
chr5_+_102808057 13.21 ENST00000684043.1
ENST00000682407.1
peptidylglycine alpha-amidating monooxygenase
chr16_+_3018390 12.47 ENST00000573001.5
TNF receptor superfamily member 12A
chr7_+_134779663 12.26 ENST00000361901.6
caldesmon 1
chr13_-_110307131 11.92 ENST00000543140.6
ENST00000375820.10
collagen type IV alpha 1 chain
chr1_-_25906457 11.00 ENST00000426559.6
stathmin 1
chr7_+_134779625 10.67 ENST00000454108.5
ENST00000361675.7
caldesmon 1
chr6_+_113857333 10.37 ENST00000612661.2
myristoylated alanine rich protein kinase C substrate
chr4_+_41612892 10.26 ENST00000509454.5
ENST00000396595.7
ENST00000381753.8
LIM and calponin homology domains 1
chr6_-_134318097 9.63 ENST00000367858.10
ENST00000533224.1
serum/glucocorticoid regulated kinase 1
chr12_-_52926459 9.14 ENST00000552150.5
keratin 8
chr13_+_110307276 9.11 ENST00000360467.7
ENST00000650540.1
collagen type IV alpha 2 chain
chr1_-_201507116 8.88 ENST00000340006.7
ENST00000526256.5
ENST00000526723.5
ENST00000524951.5
cysteine and glycine rich protein 1
chr4_+_41612702 8.76 ENST00000509277.5
LIM and calponin homology domains 1
chr7_-_108003122 8.37 ENST00000393559.2
ENST00000222399.11
ENST00000676777.1
ENST00000439976.6
ENST00000393560.5
ENST00000677793.1
ENST00000679244.1
laminin subunit beta 1
chr3_-_120450981 8.29 ENST00000424703.6
ENST00000469005.1
ENST00000295633.8
follistatin like 1
chr11_-_102452758 8.12 ENST00000398136.7
ENST00000361236.7
transmembrane protein 123
chr5_-_39425187 7.78 ENST00000545653.5
DAB adaptor protein 2
chr2_-_37671633 7.77 ENST00000295324.4
CDC42 effector protein 3
chr15_+_76931704 7.48 ENST00000320963.9
ENST00000394885.8
ENST00000394883.3
reticulocalbin 2
chr1_-_94927079 7.42 ENST00000370206.9
ENST00000394202.8
calponin 3
chr2_-_1744442 7.30 ENST00000433670.5
ENST00000425171.1
ENST00000252804.9
peroxidasin
chr12_+_53097656 7.29 ENST00000301464.4
insulin like growth factor binding protein 6
chr2_-_86563382 7.28 ENST00000263856.9
charged multivesicular body protein 3
chr18_+_3451647 7.14 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGFB induced factor homeobox 1
chr4_+_87975667 7.09 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
secreted phosphoprotein 1
chr3_-_123620496 6.89 ENST00000578202.1
myosin light chain kinase
chr17_-_42136431 6.88 ENST00000552162.5
ENST00000550504.5
RAB5C, member RAS oncogene family
chr3_-_123620571 6.83 ENST00000583087.5
myosin light chain kinase
chr16_+_33802683 6.76 ENST00000570121.2
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr12_-_57752265 6.75 ENST00000547281.5
ENST00000257904.11
ENST00000546489.5
ENST00000552388.1
cyclin dependent kinase 4
chr7_+_77538059 6.48 ENST00000435495.6
protein tyrosine phosphatase non-receptor type 12
chr18_+_3449817 6.46 ENST00000407501.6
TGFB induced factor homeobox 1
chr5_-_39424966 6.40 ENST00000515700.5
ENST00000320816.11
ENST00000339788.10
DAB adaptor protein 2
chr18_+_3450036 6.20 ENST00000546979.5
ENST00000343820.10
ENST00000551402.1
ENST00000577543.5
TGFB induced factor homeobox 1
chr5_+_83471736 6.12 ENST00000265077.8
versican
chr1_+_67685342 6.11 ENST00000617962.2
growth arrest and DNA damage inducible alpha
chr2_+_10123171 6.04 ENST00000615152.5
ribonucleotide reductase regulatory subunit M2
chr7_+_116672187 5.99 ENST00000318493.11
ENST00000397752.8
MET proto-oncogene, receptor tyrosine kinase
chr19_-_1568301 5.91 ENST00000402693.5
mex-3 RNA binding family member D
chr1_+_67685170 5.91 ENST00000370985.4
ENST00000370986.9
ENST00000650283.1
ENST00000648742.1
growth arrest and DNA damage inducible alpha
chr7_-_149028651 5.68 ENST00000286091.9
protein disulfide isomerase family A member 4
chr12_+_56041893 5.55 ENST00000552361.1
ENST00000646449.2
ribosomal protein S26
chr6_-_128520358 5.31 ENST00000368215.7
ENST00000532331.5
ENST00000368213.9
ENST00000368207.7
ENST00000525459.1
ENST00000368226.9
ENST00000368210.7
protein tyrosine phosphatase receptor type K
chr8_-_140800535 5.26 ENST00000521986.5
ENST00000523539.5
protein tyrosine kinase 2
chr7_-_149028452 5.25 ENST00000413966.1
ENST00000652332.1
protein disulfide isomerase family A member 4
chr6_-_106975452 5.15 ENST00000619869.1
ENST00000619133.4
CD24 molecule
chr12_-_49187369 5.11 ENST00000547939.6
tubulin alpha 1a
chr14_-_106470788 5.07 ENST00000434710.1
immunoglobulin heavy variable 3-43
chr5_+_141359970 5.04 ENST00000522605.2
ENST00000622527.1
protocadherin gamma subfamily B, 2
chr8_-_42501224 4.90 ENST00000520262.6
ENST00000517366.1
solute carrier family 20 member 2
chr1_-_25906931 4.86 ENST00000357865.6
stathmin 1
chr12_+_69585666 4.86 ENST00000543146.2
chaperonin containing TCP1 subunit 2
chr3_+_23810436 4.78 ENST00000467766.5
ENST00000424381.5
ubiquitin conjugating enzyme E2 E1
chr11_+_60924452 4.75 ENST00000453848.7
ENST00000544065.5
ENST00000005286.8
transmembrane protein 132A
chr13_+_99501464 4.74 ENST00000376387.5
transmembrane 9 superfamily member 2
chr2_-_37672448 4.73 ENST00000611976.1
CDC42 effector protein 3
chr3_-_57597325 4.66 ENST00000496292.5
ENST00000489843.1
ENST00000303436.11
ADP ribosylation factor 4
chr11_-_95910665 4.62 ENST00000674610.1
ENST00000675660.1
myotubularin related protein 2
chr11_-_95910824 4.56 ENST00000674528.1
ENST00000675477.1
ENST00000675636.1
myotubularin related protein 2
chr17_-_81512671 4.27 ENST00000679480.1
ENST00000644774.2
ENST00000571721.6
ENST00000575842.5
ENST00000575087.5
ENST00000573283.7
ENST00000571691.6
ENST00000570382.2
actin gamma 1
chr12_-_57752345 4.25 ENST00000551800.5
ENST00000549606.5
ENST00000312990.10
cyclin dependent kinase 4
chrX_-_154371210 4.21 ENST00000369856.8
ENST00000422373.6
ENST00000360319.9
filamin A
chr11_-_10808913 4.20 ENST00000527419.6
ENST00000530211.6
ENST00000339995.11
ENST00000530702.2
ENST00000524932.6
ENST00000532570.6
eukaryotic translation initiation factor 4 gamma 2
chr1_+_40040219 4.20 ENST00000372797.7
ENST00000372802.5
ENST00000449311.5
cyclase associated actin cytoskeleton regulatory protein 1
chr1_+_19644284 4.17 ENST00000375136.8
NBL1, DAN family BMP antagonist
chr12_+_68610858 4.14 ENST00000393436.9
ENST00000425247.6
ENST00000250559.14
ENST00000489473.6
ENST00000422358.6
ENST00000541167.5
ENST00000538283.5
ENST00000341355.9
ENST00000537460.5
ENST00000450214.6
ENST00000545270.5
RAP1B, member of RAS oncogene family
chr11_-_95910748 4.13 ENST00000675933.1
myotubularin related protein 2
chr16_+_89923333 4.12 ENST00000315491.12
ENST00000555576.5
ENST00000554336.5
ENST00000553967.1
tubulin beta 3 class III
chrX_+_12975216 4.10 ENST00000380635.5
thymosin beta 4 X-linked
chr13_-_23433676 4.09 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
sacsin molecular chaperone
chr16_+_56936654 4.04 ENST00000563911.5
homocysteine inducible ER protein with ubiquitin like domain 1
chr20_-_40689228 4.02 ENST00000373313.3
MAF bZIP transcription factor B
chr2_+_54456311 3.97 ENST00000615901.4
ENST00000356805.9
spectrin beta, non-erythrocytic 1
chr2_-_37672178 3.96 ENST00000457889.1
CDC42 effector protein 3
chr12_+_10929229 3.89 ENST00000381847.7
ENST00000396400.4
proline rich protein HaeIII subfamily 2
chr11_+_46381033 3.87 ENST00000359803.7
midkine
chr6_+_30721573 3.86 ENST00000330914.7
tubulin beta class I
chr5_-_157575767 3.83 ENST00000257527.9
ADAM metallopeptidase domain 19
chr5_+_141350081 3.80 ENST00000523390.2
ENST00000611598.1
protocadherin gamma subfamily B, 1
chr8_+_26577843 3.80 ENST00000311151.9
dihydropyrimidinase like 2
chr13_-_23433735 3.77 ENST00000423156.2
ENST00000683210.1
ENST00000682775.1
ENST00000684497.1
ENST00000682944.1
ENST00000683489.1
ENST00000684385.1
ENST00000683680.1
sacsin molecular chaperone
chr2_-_9630491 3.72 ENST00000381844.8
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
chr10_+_102776237 3.71 ENST00000369889.5
WW domain binding protein 1 like
chr17_+_54900795 3.66 ENST00000348161.8
target of myb1 like 1 membrane trafficking protein
chr5_-_16936231 3.63 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
myosin X
chr21_+_6111123 3.57 ENST00000613488.3
salt inducible kinase 1B (putative)
chr8_-_101206064 3.55 ENST00000518336.5
ENST00000520454.1
zinc finger protein 706
chr4_-_185810894 3.45 ENST00000448662.6
ENST00000439049.5
ENST00000420158.5
ENST00000319471.13
sorbin and SH3 domain containing 2
chr20_+_63520746 3.45 ENST00000370179.8
ENST00000370177.1
pancreatic progenitor cell differentiation and proliferation factor
chr2_+_231708511 3.41 ENST00000341369.11
ENST00000409115.8
ENST00000409683.5
prothymosin alpha
chr7_+_99408609 3.35 ENST00000403633.6
BUD31 homolog
chr10_-_13348270 3.32 ENST00000378614.8
ENST00000327347.10
ENST00000545675.5
selenophosphate synthetase 1
chr16_-_73048104 3.31 ENST00000268489.10
zinc finger homeobox 3
chr14_-_106389858 3.31 ENST00000390617.2
immunoglobulin heavy variable 3-35 (non-functional)
chr12_-_8662619 3.27 ENST00000544889.1
ENST00000543369.5
microfibril associated protein 5
chr2_+_71068636 3.16 ENST00000244204.11
ENST00000533981.5
N-acetylglucosamine kinase
chr2_+_10122730 3.08 ENST00000304567.10
ribonucleotide reductase regulatory subunit M2
chr5_+_72816643 3.06 ENST00000337273.10
ENST00000523768.5
transportin 1
chr9_-_71768386 2.92 ENST00000377066.9
ENST00000377044.9
cell migration inducing hyaluronidase 2
chr12_+_69239627 2.92 ENST00000551516.1
cleavage and polyadenylation specific factor 6
chr17_+_77287891 2.92 ENST00000449803.6
ENST00000431235.6
septin 9
chr10_+_122163590 2.89 ENST00000368999.5
transforming acidic coiled-coil containing protein 2
chr11_+_46381194 2.87 ENST00000533952.5
midkine
chr2_+_101697699 2.83 ENST00000350878.8
ENST00000350198.8
ENST00000324219.8
ENST00000425019.5
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_49188811 2.81 ENST00000295766.9
tubulin alpha 1a
chr19_+_46602050 2.81 ENST00000599839.5
ENST00000596362.1
calmodulin 3
chr17_-_1684807 2.76 ENST00000577001.1
ENST00000572621.5
ENST00000304992.11
pre-mRNA processing factor 8
chr7_+_16753731 2.75 ENST00000262067.5
tetraspanin 13
chr12_+_69239592 2.73 ENST00000456847.7
ENST00000266679.8
cleavage and polyadenylation specific factor 6
chr5_+_87267792 2.69 ENST00000274376.11
RAS p21 protein activator 1
chr1_-_25906411 2.62 ENST00000455785.7
stathmin 1
chr11_-_62646598 2.62 ENST00000648273.1
ENST00000356638.8
ENST00000346178.8
ENST00000534779.5
ENST00000525994.1
ENST00000540933.5
glucosidase II alpha subunit
chr14_-_106235582 2.59 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr19_+_5681140 2.59 ENST00000579559.1
ENST00000577222.5
hydroxysteroid 11-beta dehydrogenase 1 like
ribosomal protein L36
chr20_-_44521989 2.56 ENST00000342374.5
ENST00000255175.5
serine incorporator 3
chr22_+_38656627 2.51 ENST00000411557.5
ENST00000396811.6
ENST00000216029.7
ENST00000416285.5
chibby family member 1, beta catenin antagonist
chr15_+_78873723 2.45 ENST00000559690.5
ENST00000559158.5
mortality factor 4 like 1
chr17_+_77376083 2.41 ENST00000427674.6
septin 9
chr14_+_55051639 2.35 ENST00000395468.9
ENST00000622254.1
mitogen-activated protein kinase 1 interacting protein 1 like
chr3_+_52685995 2.35 ENST00000394799.6
ENST00000418458.6
G protein nucleolar 3
chr11_+_65182413 2.28 ENST00000531068.5
ENST00000527699.5
ENST00000533909.5
ENST00000527323.5
calpain 1
chr8_-_119673368 2.26 ENST00000427067.6
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr9_-_83980190 2.25 ENST00000457156.5
ENST00000376263.8
ENST00000360384.9
heterogeneous nuclear ribonucleoprotein K
chr4_+_70050431 2.23 ENST00000511674.5
ENST00000246896.8
histatin 1
chr1_+_93448155 2.22 ENST00000370253.6
formin binding protein 1 like
chr12_+_77830886 2.19 ENST00000397909.7
ENST00000549464.5
neuron navigator 3
chr19_+_48965304 2.16 ENST00000331825.11
ferritin light chain
chr7_+_5592805 2.16 ENST00000382361.8
fascin actin-bundling protein 1
chr6_+_31815532 2.15 ENST00000375651.7
ENST00000608703.1
heat shock protein family A (Hsp70) member 1A
chr9_-_72364504 2.11 ENST00000237937.7
ENST00000343431.6
ENST00000376956.3
zinc finger AN1-type containing 5
chr17_-_19745369 2.08 ENST00000573368.5
ENST00000457500.6
aldehyde dehydrogenase 3 family member A1
chr10_+_122163426 2.08 ENST00000360561.7
transforming acidic coiled-coil containing protein 2
chr21_-_15064934 2.05 ENST00000400199.5
ENST00000400202.5
ENST00000318948.7
nuclear receptor interacting protein 1
chr4_+_26321192 2.05 ENST00000681484.1
recombination signal binding protein for immunoglobulin kappa J region
chr11_+_65181920 2.01 ENST00000279247.11
ENST00000532285.1
ENST00000534373.5
calpain 1
chr19_+_48469354 1.95 ENST00000452733.7
ENST00000641098.1
cytohesin 2
chr10_+_22321056 1.92 ENST00000376663.8
BMI1 proto-oncogene, polycomb ring finger
chr14_+_22836574 1.92 ENST00000548162.2
ENST00000311852.11
matrix metallopeptidase 14
chr1_-_32336224 1.87 ENST00000329421.8
MARCKS like 1
chr4_-_142305935 1.87 ENST00000511838.5
inositol polyphosphate-4-phosphatase type II B
chr4_+_26321365 1.84 ENST00000505958.6
recombination signal binding protein for immunoglobulin kappa J region
chr1_-_155910881 1.82 ENST00000609492.1
ENST00000368322.7
Ras like without CAAX 1
chr20_-_35954461 1.78 ENST00000305978.7
SCAN domain containing 1
chr10_-_29735787 1.77 ENST00000375400.7
supervillin
chr1_+_150067279 1.77 ENST00000643970.1
ENST00000535106.5
ENST00000369128.9
vacuolar protein sorting 45 homolog
chr15_-_58749569 1.75 ENST00000402627.5
ENST00000559053.1
ENST00000260408.8
ENST00000561288.1
ENST00000461408.2
ENST00000439637.5
ENST00000558004.1
ADAM metallopeptidase domain 10
chr3_-_115071333 1.74 ENST00000462705.5
zinc finger and BTB domain containing 20
chr14_-_106117159 1.73 ENST00000390601.3
immunoglobulin heavy variable 3-11
chr10_+_122163672 1.70 ENST00000369004.7
ENST00000260733.7
transforming acidic coiled-coil containing protein 2
chr11_+_36296281 1.67 ENST00000530639.6
proline rich 5 like
chr8_+_106726012 1.66 ENST00000449762.6
ENST00000297447.10
oxidation resistance 1
chr2_-_151828408 1.65 ENST00000295087.13
ADP ribosylation factor like GTPase 5A
chrX_+_71283577 1.64 ENST00000420903.6
ENST00000373856.8
ENST00000678437.1
ENST00000678830.1
ENST00000677879.1
ENST00000373841.5
ENST00000276079.13
ENST00000676797.1
ENST00000678660.1
ENST00000678231.1
ENST00000677612.1
ENST00000413858.5
ENST00000450092.6
non-POU domain containing octamer binding
chr17_-_54968637 1.59 ENST00000299335.8
cytochrome c oxidase copper chaperone COX11
chr12_+_22625075 1.58 ENST00000671733.1
ENST00000335148.8
ENST00000672951.1
ENST00000266517.9
ethanolamine kinase 1
chr1_-_93180261 1.57 ENST00000370280.1
ENST00000479918.5
transmembrane p24 trafficking protein 5
chr8_-_30658176 1.57 ENST00000355904.9
general transcription factor IIE subunit 2
chr15_+_89088417 1.51 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
abhydrolase domain containing 2, acylglycerol lipase
chr15_+_85380565 1.48 ENST00000559362.5
ENST00000394518.7
A-kinase anchoring protein 13
chr15_+_64095967 1.46 ENST00000559844.6
ENST00000261889.9
ENST00000625244.2
ENST00000561026.5
ENST00000558040.5
sorting nexin 1
chr1_-_25905989 1.43 ENST00000399728.5
stathmin 1
chr11_-_60952067 1.37 ENST00000681275.1
solute carrier family 15 member 3
chr3_+_152268920 1.36 ENST00000495875.6
ENST00000324210.10
ENST00000493459.5
muscleblind like splicing regulator 1
chr4_-_142305826 1.35 ENST00000514525.1
inositol polyphosphate-4-phosphatase type II B
chr12_+_103965863 1.35 ENST00000392872.8
ENST00000537100.5
thymine DNA glycosylase
chr9_+_98943705 1.31 ENST00000610452.1
collagen type XV alpha 1 chain
chr8_-_28386417 1.30 ENST00000521185.5
ENST00000520290.5
ENST00000344423.10
zinc finger protein 395
chr6_+_32969345 1.27 ENST00000678250.1
bromodomain containing 2
chr1_+_172533104 1.26 ENST00000616058.4
ENST00000263688.4
ENST00000610051.5
SUN domain containing ossification factor
chr4_-_7939789 1.22 ENST00000420658.6
ENST00000358461.6
actin filament associated protein 1
chr12_-_8662808 1.21 ENST00000359478.7
ENST00000396549.6
microfibril associated protein 5
chr7_+_77538027 1.17 ENST00000433369.6
ENST00000415482.6
protein tyrosine phosphatase non-receptor type 12
chr2_-_216695540 1.06 ENST00000233813.5
insulin like growth factor binding protein 5
chr8_-_28386073 1.06 ENST00000523095.5
ENST00000522795.1
zinc finger protein 395
chr17_-_51046868 1.06 ENST00000510283.5
ENST00000510855.1
sperm associated antigen 9
chr14_+_23322019 1.05 ENST00000557702.5
poly(A) binding protein nuclear 1
chr7_+_102912983 1.05 ENST00000339431.9
ENST00000249377.4
leucine rich repeat containing 17
chr4_-_185956348 1.02 ENST00000431902.5
ENST00000284776.11
ENST00000415274.5
sorbin and SH3 domain containing 2
chr3_-_197298000 1.02 ENST00000664991.1
discs large MAGUK scaffold protein 1
chr6_+_32969165 0.97 ENST00000496118.2
ENST00000449085.4
bromodomain containing 2
chr11_-_79441016 0.93 ENST00000278550.12
teneurin transmembrane protein 4
chr11_-_60952134 0.92 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
solute carrier family 15 member 3
chr1_+_13585453 0.91 ENST00000487038.5
ENST00000475043.5
podoplanin
chr16_+_3654683 0.91 ENST00000246949.10
deoxyribonuclease 1
chr8_+_11802611 0.89 ENST00000623368.3
farnesyl-diphosphate farnesyltransferase 1
chr14_+_49768109 0.89 ENST00000298307.10
ENST00000554589.5
ENST00000557247.1
kelch domain containing 2
chr7_+_107583919 0.88 ENST00000491150.5
B cell receptor associated protein 29
chr12_+_22625182 0.87 ENST00000538218.2
ethanolamine kinase 1
chrX_+_12975083 0.87 ENST00000451311.7
ENST00000380636.1
thymosin beta 4 X-linked
chr9_+_131394042 0.85 ENST00000684596.1
ENST00000683519.1
ENST00000682501.1
proline rich coiled-coil 2B
chr4_+_26584064 0.84 ENST00000264866.9
ENST00000505206.5
ENST00000511789.5
TBC1 domain family member 19
chr2_+_69013414 0.82 ENST00000681816.1
ENST00000482235.2
ANTXR cell adhesion molecule 1
chr21_+_37073213 0.82 ENST00000418766.5
ENST00000450533.5
ENST00000438055.5
ENST00000355666.5
ENST00000540756.5
ENST00000399010.5
tetratricopeptide repeat domain 3
chr8_+_11802667 0.80 ENST00000443614.6
ENST00000220584.9
ENST00000525900.5
farnesyl-diphosphate farnesyltransferase 1
chr20_+_6767678 0.79 ENST00000378827.5
bone morphogenetic protein 2
chr2_+_69013379 0.79 ENST00000409349.7
ANTXR cell adhesion molecule 1
chr17_+_16381462 0.78 ENST00000578706.5
ENST00000614404.1
ubiquitin B
chr8_+_94641074 0.77 ENST00000423620.6
epithelial splicing regulatory protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.2 GO:0035026 leading edge cell differentiation(GO:0035026)
4.6 18.4 GO:0032597 B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
3.3 13.2 GO:0018032 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
3.0 11.9 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
2.4 7.1 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
2.3 13.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.2 11.0 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
2.1 12.5 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
1.8 21.9 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.4 4.2 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.4 9.6 GO:0070294 renal sodium ion absorption(GO:0070294)
1.2 15.0 GO:0009414 response to water deprivation(GO:0009414)
1.2 13.3 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
1.0 4.2 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
1.0 4.0 GO:0035284 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
1.0 4.0 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.0 6.7 GO:0030421 defecation(GO:0030421)
0.9 13.9 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.8 7.6 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.7 7.3 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.7 4.9 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.7 3.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.7 9.1 GO:0009415 response to water(GO:0009415) response to hydrostatic pressure(GO:0051599)
0.7 9.1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.6 5.0 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) negative regulation of interleukin-8 secretion(GO:2000483)
0.6 4.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.6 2.2 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.6 3.4 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.6 10.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.6 3.9 GO:0060844 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.5 8.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.5 2.2 GO:0030035 microspike assembly(GO:0030035)
0.5 6.9 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.5 3.2 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.5 4.7 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.5 12.8 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.5 3.5 GO:0031017 exocrine pancreas development(GO:0031017)
0.5 1.9 GO:1990834 response to odorant(GO:1990834)
0.5 0.9 GO:0032289 central nervous system myelin formation(GO:0032289)
0.5 5.9 GO:0008298 intracellular mRNA localization(GO:0008298)
0.5 10.4 GO:0051764 actin crosslink formation(GO:0051764)
0.4 4.9 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.4 1.8 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.4 2.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.4 3.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.4 5.3 GO:0051964 netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964)
0.4 7.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 9.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.4 4.3 GO:0060056 mammary gland involution(GO:0060056)
0.4 1.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.3 1.0 GO:1904247 regulation of polynucleotide adenylyltransferase activity(GO:1904245) positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.3 1.3 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.3 4.0 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.3 5.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.3 2.6 GO:0009597 detection of virus(GO:0009597)
0.3 2.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3 0.9 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.3 1.7 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.3 6.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 6.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 0.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 7.0 GO:0030033 microvillus assembly(GO:0030033)
0.2 7.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 2.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 1.0 GO:0048539 bone marrow development(GO:0048539)
0.2 3.5 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.2 1.6 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.2 3.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 1.8 GO:1902255 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) fat pad development(GO:0060613) positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) positive regulation of protein monoubiquitination(GO:1902527)
0.2 1.9 GO:0007379 segment specification(GO:0007379)
0.2 14.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 3.7 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.2 2.4 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.2 1.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 2.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 8.4 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.1 0.7 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 13.2 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.7 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 2.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 4.5 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 5.5 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.1 2.5 GO:0046337 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.1 1.7 GO:0038203 TORC2 signaling(GO:0038203)
0.1 9.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 4.5 GO:0097435 fibril organization(GO:0097435)
0.1 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 1.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 2.2 GO:0097320 membrane tubulation(GO:0097320)
0.1 1.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 4.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 0.8 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 2.9 GO:0048745 smooth muscle tissue development(GO:0048745)
0.1 0.1 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.1 3.7 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 1.5 GO:0048240 sperm capacitation(GO:0048240)
0.1 4.8 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 2.7 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.1 2.2 GO:0050832 defense response to fungus(GO:0050832)
0.1 3.9 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 0.6 GO:0051601 exocyst localization(GO:0051601)
0.1 1.3 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.0 8.3 GO:0042594 response to starvation(GO:0042594)
0.0 18.8 GO:0042493 response to drug(GO:0042493)
0.0 5.8 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 7.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 4.4 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.8 GO:0007143 female meiotic division(GO:0007143)
0.0 2.7 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)
0.0 1.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 17.1 GO:0006936 muscle contraction(GO:0006936)
0.0 2.5 GO:0051289 protein homotetramerization(GO:0051289)
0.0 8.2 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 2.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 2.5 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0 0.9 GO:0006308 DNA catabolic process(GO:0006308)
0.0 0.4 GO:0016540 protein autoprocessing(GO:0016540)
0.0 2.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.8 GO:0015992 proton transport(GO:0015992)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.6 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.6 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.8 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.8 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0051572 negative regulation of histone H3-K36 methylation(GO:0000415) negative regulation of histone H3-K4 methylation(GO:0051572)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.4 GO:0005606 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
2.6 21.0 GO:0005587 collagen type IV trimer(GO:0005587)
2.4 14.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
2.3 9.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.8 11.0 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
1.5 22.9 GO:0030478 actin cap(GO:0030478)
0.8 4.2 GO:0031523 Myb complex(GO:0031523)
0.8 7.9 GO:0070852 cell body fiber(GO:0070852)
0.8 18.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.7 2.2 GO:0044393 microspike(GO:0044393)
0.7 8.4 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.7 4.0 GO:0032437 cuticular plate(GO:0032437)
0.6 10.4 GO:0043073 germ cell nucleus(GO:0043073)
0.6 5.6 GO:0042382 paraspeckles(GO:0042382)
0.6 4.0 GO:1990037 Lewy body core(GO:1990037)
0.6 7.3 GO:0000815 ESCRT III complex(GO:0000815)
0.5 2.2 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.4 1.3 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.4 3.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 18.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.3 4.3 GO:0097433 dense body(GO:0097433)
0.3 1.9 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.3 9.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 2.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 4.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 5.8 GO:0031527 filopodium membrane(GO:0031527)
0.3 4.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 11.7 GO:0002102 podosome(GO:0002102)
0.2 8.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 4.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 13.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 3.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 2.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 11.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 2.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.9 GO:0035102 PRC1 complex(GO:0035102)
0.1 42.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 7.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 22.2 GO:0043197 dendritic spine(GO:0043197)
0.1 2.8 GO:0005682 U5 snRNP(GO:0005682)
0.1 5.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.7 GO:0031932 TORC2 complex(GO:0031932)
0.1 1.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 2.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.1 1.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 5.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 4.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 13.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 25.3 GO:0005925 focal adhesion(GO:0005925)
0.0 4.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 19.2 GO:0005874 microtubule(GO:0005874)
0.0 2.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 6.1 GO:0001726 ruffle(GO:0001726)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 17.2 GO:0016607 nuclear speck(GO:0016607)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 2.8 GO:0000922 spindle pole(GO:0000922)
0.0 5.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.3 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.1 GO:1903349 omegasome membrane(GO:1903349)
0.0 4.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.4 GO:0005771 multivesicular body(GO:0005771)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
3.4 13.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
3.3 13.2 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
2.3 9.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.7 11.9 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
1.5 7.3 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
1.3 3.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
1.0 4.9 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
1.0 4.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.8 4.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.8 22.1 GO:0005523 tropomyosin binding(GO:0005523)
0.8 3.2 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.7 8.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.7 19.8 GO:0070410 co-SMAD binding(GO:0070410)
0.6 3.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.6 14.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.6 4.2 GO:0016015 morphogen activity(GO:0016015)
0.6 7.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.6 2.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.5 10.9 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.5 11.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.5 18.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.5 3.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.5 1.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.4 1.3 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.4 2.5 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.4 7.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.4 2.3 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.4 9.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.4 2.8 GO:0004111 creatine kinase activity(GO:0004111)
0.3 7.7 GO:0070628 proteasome binding(GO:0070628)
0.3 2.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.3 2.8 GO:0030620 U2 snRNA binding(GO:0030620)
0.3 18.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 6.3 GO:0008432 JUN kinase binding(GO:0008432)
0.3 2.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 29.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 1.5 GO:1990460 leptin receptor binding(GO:1990460)
0.3 1.7 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.3 1.9 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.3 10.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 6.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 3.9 GO:0000150 recombinase activity(GO:0000150)
0.2 4.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 2.2 GO:0008199 ferric iron binding(GO:0008199)
0.2 5.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 2.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 4.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.9 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.2 2.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 2.1 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 0.8 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 3.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 3.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 4.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 8.6 GO:0005080 protein kinase C binding(GO:0005080)
0.1 11.0 GO:0019003 GDP binding(GO:0019003)
0.1 4.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 5.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 18.6 GO:0005178 integrin binding(GO:0005178)
0.1 7.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 8.9 GO:0097110 scaffold protein binding(GO:0097110)
0.1 4.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 16.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 4.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 2.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.8 GO:0039706 co-receptor binding(GO:0039706)
0.1 12.0 GO:0008201 heparin binding(GO:0008201)
0.1 2.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 4.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 3.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 3.7 GO:0030276 clathrin binding(GO:0030276)
0.1 0.9 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 9.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 2.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.8 GO:0097016 L27 domain binding(GO:0097016)
0.0 10.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 18.3 GO:0003779 actin binding(GO:0003779)
0.0 4.0 GO:0044325 ion channel binding(GO:0044325)
0.0 0.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 1.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.0 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 2.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.1 GO:0003823 antigen binding(GO:0003823)
0.0 0.0 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 3.6 GO:0005525 GTP binding(GO:0005525)
0.0 1.4 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 3.0 GO:0015631 tubulin binding(GO:0015631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 17.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.7 30.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.4 7.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 24.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 12.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 20.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 11.2 PID INSULIN PATHWAY Insulin Pathway
0.2 9.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 10.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 17.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 13.8 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.2 6.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 24.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 2.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 5.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 7.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 7.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 20.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 2.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 9.1 PID E2F PATHWAY E2F transcription factor network
0.1 2.0 PID ARF 3PATHWAY Arf1 pathway
0.1 5.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 1.8 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 2.1 PID FOXO PATHWAY FoxO family signaling
0.0 5.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 16.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.8 9.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.7 39.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.7 14.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.5 16.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 9.4 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4 19.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 8.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 22.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 11.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 9.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 3.9 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 1.8 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 4.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 6.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 30.7 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.2 4.8 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.2 7.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 4.0 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 2.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 3.1 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.2 2.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 19.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 9.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.8 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 3.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 6.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 1.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.0 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.9 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 2.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 4.9 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 4.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 6.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.6 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 2.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 2.6 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling