Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX7

Z-value: 3.78

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.8 SOX7
PINX1
ENSG00000258724.1 PINX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX7hg38_v1_chr8_-_10730498_107305250.621.3e-24Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_+_35241027 10.92 ENST00000330501.12
ENST00000601719.1
ENST00000591206.5
ENST00000261333.10
ENST00000355632.8
ENST00000585800.1
ZNF397
zinc finger protein 397
chr16_-_33845229 9.34 ENST00000569103.2
IGHV3OR16-17
immunoglobulin heavy variable 3/OR16-17 (non-functional)
chr2_-_89100352 8.15 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr15_+_75347030 8.00 ENST00000566313.5
ENST00000355059.9
ENST00000568059.1
ENST00000568881.1
NEIL1
nei like DNA glycosylase 1
chr14_-_106117159 7.76 ENST00000390601.3
IGHV3-11
immunoglobulin heavy variable 3-11
chr17_-_35880350 6.58 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
CCL5
C-C motif chemokine ligand 5
chr1_+_158931539 6.28 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
PYHIN1
pyrin and HIN domain family member 1
chr16_+_33009175 6.23 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr1_+_100133135 5.39 ENST00000370143.5
ENST00000370141.7
TRMT13
tRNA methyltransferase 13 homolog
chr8_+_28338640 5.33 ENST00000522209.1
PNOC
prepronociceptin
chr9_+_102995308 4.85 ENST00000612124.4
ENST00000374798.8
ENST00000487798.5
CYLC2
cylicin 2
chr8_-_19602484 4.74 ENST00000454498.6
ENST00000520003.5
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr2_-_89222461 4.56 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr5_+_162067858 4.49 ENST00000361925.9
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr5_+_162067458 4.26 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr5_+_162067500 3.88 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr19_-_2783308 3.65 ENST00000677562.1
ENST00000677754.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr19_-_2783241 3.64 ENST00000676943.1
ENST00000589251.5
ENST00000221566.7
ENST00000676984.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr1_+_10450004 3.48 ENST00000377049.4
CORT
cortistatin
chr16_-_229398 3.36 ENST00000430864.5
ENST00000293872.13
ENST00000629543.2
ENST00000337351.8
ENST00000397783.5
LUC7L
LUC7 like
chr22_+_22720615 3.35 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr6_+_150368997 3.35 ENST00000392255.7
ENST00000500320.7
ENST00000344419.8
IYD
iodotyrosine deiodinase
chr5_+_162067764 3.24 ENST00000639213.2
ENST00000414552.6
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr13_-_37059432 3.22 ENST00000464744.5
SUPT20H
SPT20 homolog, SAGA complex component
chr2_+_3658193 3.16 ENST00000252505.4
ALLC
allantoicase
chr4_+_76074701 2.94 ENST00000355810.9
ENST00000349321.7
ART3
ADP-ribosyltransferase 3 (inactive)
chr6_+_131573219 2.87 ENST00000356962.2
ENST00000368087.8
ENST00000673427.1
ENST00000640973.1
ARG1
arginase 1
chr4_-_47981535 2.58 ENST00000402813.9
CNGA1
cyclic nucleotide gated channel subunit alpha 1
chr1_-_158426237 2.20 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr10_+_94402486 2.18 ENST00000225235.5
TBC1D12
TBC1 domain family member 12
chr6_+_42563981 2.02 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr6_+_150368892 1.88 ENST00000229447.9
ENST00000392256.6
IYD
iodotyrosine deiodinase
chr4_+_68447453 1.86 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr8_+_12945667 1.85 ENST00000524591.7
TRMT9B
tRNA methyltransferase 9B (putative)
chr21_-_14546297 1.54 ENST00000400566.6
ENST00000400564.5
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr1_+_200027702 1.35 ENST00000367362.8
NR5A2
nuclear receptor subfamily 5 group A member 2
chr16_-_20352707 1.15 ENST00000396134.6
ENST00000573567.5
ENST00000570757.5
ENST00000396138.9
ENST00000571174.5
ENST00000576688.2
UMOD
uromodulin
chr4_-_103719980 0.95 ENST00000304883.3
TACR3
tachykinin receptor 3
chr7_-_138755892 0.73 ENST00000644341.1
ENST00000478480.2
ATP6V0A4
ATPase H+ transporting V0 subunit a4
chr10_+_4963406 0.66 ENST00000380872.9
ENST00000442997.5
AKR1C1
aldo-keto reductase family 1 member C1
chr1_+_86993009 0.65 ENST00000370548.3
ENSG00000267561.2
novel protein
chr1_+_200027605 0.63 ENST00000236914.7
NR5A2
nuclear receptor subfamily 5 group A member 2
chr11_-_62707413 0.51 ENST00000360796.10
ENST00000449636.6
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr11_+_7597182 0.46 ENST00000528883.5
PPFIBP2
PPFIA binding protein 2
chr12_-_57050102 0.31 ENST00000300119.8
MYO1A
myosin IA
chr8_+_127409026 0.26 ENST00000465342.4
POU5F1B
POU class 5 homeobox 1B
chr12_-_10420550 0.15 ENST00000381903.2
ENST00000396439.7
KLRC3
killer cell lectin like receptor C3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.3 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
1.6 6.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.6 4.7 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
1.1 3.2 GO:0043605 cellular amide catabolic process(GO:0043605)
0.7 8.0 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.7 2.9 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.6 15.9 GO:0071420 cellular response to histamine(GO:0071420)
0.4 2.0 GO:0071233 cellular response to leucine(GO:0071233)
0.4 5.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.4 2.0 GO:0061113 pancreas morphogenesis(GO:0061113)
0.4 1.2 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.3 3.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 5.4 GO:0030488 tRNA methylation(GO:0030488)
0.2 29.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.7 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 0.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 3.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 2.9 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 2.6 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 2.2 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 5.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.5 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.5 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 3.2 GO:0007369 gastrulation(GO:0007369)
0.0 0.3 GO:0030033 microvillus assembly(GO:0030033)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
1.2 3.5 GO:0071821 FANCM-MHF complex(GO:0071821)
0.4 15.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 3.2 GO:0000124 SAGA complex(GO:0000124)
0.2 3.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 2.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 4.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 6.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 2.9 GO:0035580 specific granule lumen(GO:0035580)
0.0 5.3 GO:0043679 axon terminus(GO:0043679)
0.0 2.2 GO:0005776 autophagosome(GO:0005776)
0.0 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.3 GO:0016607 nuclear speck(GO:0016607)
0.0 18.9 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 2.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.0 5.2 GO:0004447 iodide peroxidase activity(GO:0004447)
1.0 7.3 GO:1904288 BAT3 complex binding(GO:1904288)
1.0 15.9 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.9 4.7 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.8 5.3 GO:0001515 opioid peptide activity(GO:0001515)
0.6 2.9 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.4 8.0 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.4 3.4 GO:0050733 RS domain binding(GO:0050733)
0.4 6.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 2.0 GO:0070728 leucine binding(GO:0070728)
0.2 0.7 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.2 5.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.2 2.6 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.2 0.9 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 30.1 GO:0003823 antigen binding(GO:0003823)
0.1 3.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.7 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.0 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 2.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 2.9 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 15.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 5.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 4.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 6.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 6.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 2.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives