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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX8

Z-value: 6.03

Motif logo

Transcription factors associated with SOX8

Gene Symbol Gene ID Gene Info
ENSG00000005513.10 SOX8

Activity profile of SOX8 motif

Sorted Z-values of SOX8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX8

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_-_87529359 24.91 ENST00000458304.2
ENST00000282470.11
SPARC like 1
chr14_-_106025628 16.89 ENST00000631943.1
immunoglobulin heavy variable 7-4-1
chr1_+_153357846 15.80 ENST00000368738.4
S100 calcium binding protein A9
chr14_+_75278820 15.50 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
Fos proto-oncogene, AP-1 transcription factor subunit
chr2_-_174846405 14.68 ENST00000409597.5
ENST00000413882.6
chimerin 1
chr2_+_232662733 13.48 ENST00000410095.5
ENST00000611312.1
EF-hand domain family member D1
chr2_+_71453538 12.55 ENST00000258104.8
dysferlin
chr22_-_50085331 12.53 ENST00000395876.6
modulator of VRAC current 1
chr12_-_11395556 12.25 ENST00000565533.1
ENST00000389362.6
ENST00000546254.3
proline rich protein BstNI subfamily 2
proline rich protein BstNI subfamily 1
chr22_-_50085414 11.77 ENST00000311597.10
modulator of VRAC current 1
chrX_-_19965142 11.17 ENST00000340625.3
BCLAF1 and THRAP3 family member 3
chr11_-_125496122 11.12 ENST00000527534.1
ENST00000278919.8
ENST00000366139.3
fasciculation and elongation protein zeta 1
chr14_-_106507476 11.07 ENST00000390621.3
immunoglobulin heavy variable 1-45
chr14_-_106185387 10.95 ENST00000390605.2
immunoglobulin heavy variable 1-18
chr15_-_72118114 10.93 ENST00000356056.10
ENST00000569314.1
myosin IXA
chr8_+_22057857 10.42 ENST00000517305.4
ENST00000265800.9
ENST00000517418.5
dematin actin binding protein
chr14_-_106737547 10.14 ENST00000632209.1
immunoglobulin heavy variable 1-69-2
chr8_-_119592954 9.98 ENST00000522167.5
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr14_-_106875069 9.93 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr16_+_31259922 9.71 ENST00000648685.1
ENST00000544665.9
integrin subunit alpha M
chr1_+_203305510 9.43 ENST00000290551.5
BTG anti-proliferation factor 2
chr1_-_230745574 9.39 ENST00000681269.1
angiotensinogen
chr12_-_14951106 9.37 ENST00000541644.5
ENST00000545895.5
Rho GDP dissociation inhibitor beta
chr7_+_80646305 9.30 ENST00000426978.5
ENST00000432207.5
CD36 molecule
chr12_-_16600703 9.16 ENST00000616247.4
LIM domain only 3
chr6_+_32637419 9.13 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr2_+_89947508 8.99 ENST00000491977.1
immunoglobulin kappa variable 2D-29
chr12_-_10130241 8.98 ENST00000353231.9
ENST00000525605.1
C-type lectin domain containing 7A
chr7_+_80646436 8.78 ENST00000419819.2
CD36 molecule
chr15_+_72118392 8.70 ENST00000340912.6
SUMO peptidase family member, NEDD8 specific
chr1_-_201023694 8.54 ENST00000332129.6
ENST00000422435.2
ENST00000461742.7
kinesin family member 21B
chr18_+_74148508 8.35 ENST00000580087.5
ENST00000169551.11
translocase of inner mitochondrial membrane 21
chr1_-_38046785 8.20 ENST00000373012.5
POU class 3 homeobox 1
chr2_-_222656067 8.01 ENST00000281828.8
phenylalanyl-tRNA synthetase subunit beta
chr5_-_160852200 7.90 ENST00000327245.10
ATPase phospholipid transporting 10B (putative)
chr2_+_200440649 7.79 ENST00000366118.2
spermatogenesis associated serine rich 2 like
chr14_+_94612383 7.67 ENST00000393080.8
ENST00000555820.1
ENST00000393078.5
ENST00000467132.5
serpin family A member 3
chr16_+_8712943 7.64 ENST00000561870.5
ENST00000396600.6
4-aminobutyrate aminotransferase
chr1_+_110873135 7.63 ENST00000271324.6
CD53 molecule
chr4_-_70666492 7.57 ENST00000254801.9
ENST00000391614.7
joining chain of multimeric IgA and IgM
chr11_+_125904467 7.51 ENST00000263576.11
ENST00000530414.5
ENST00000530129.6
DEAD-box helicase 25
chr22_+_19723525 7.48 ENST00000366425.4
glycoprotein Ib platelet subunit beta
chr3_+_138347648 7.21 ENST00000614350.4
ENST00000289104.8
muscle RAS oncogene homolog
chr2_-_152098810 7.21 ENST00000636442.1
ENST00000638005.1
calcium voltage-gated channel auxiliary subunit beta 4
chr6_+_32637396 7.11 ENST00000395363.5
ENST00000496318.5
ENST00000343139.11
major histocompatibility complex, class II, DQ alpha 1
chr7_+_153887081 6.99 ENST00000404039.5
dipeptidyl peptidase like 6
chr19_+_19033575 6.96 ENST00000392335.6
ENST00000537263.5
ENST00000540707.5
ENST00000535612.6
ENST00000541725.5
ENST00000269932.10
ENST00000546344.5
ENST00000540792.5
ENST00000536098.5
ENST00000541898.5
armadillo repeat containing 6
chr4_-_86101922 6.96 ENST00000472236.5
ENST00000641881.1
mitogen-activated protein kinase 10
chr12_-_10130143 6.91 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
C-type lectin domain containing 7A
chr11_+_128694052 6.84 ENST00000527786.7
ENST00000534087.3
Fli-1 proto-oncogene, ETS transcription factor
chr1_-_153057504 6.79 ENST00000392653.3
small proline rich protein 2A
chr17_-_68955332 6.53 ENST00000269080.6
ENST00000615593.4
ENST00000586539.6
ENST00000430352.6
ATP binding cassette subfamily A member 8
chr9_+_128203397 6.19 ENST00000628346.2
ENST00000486160.3
ENST00000627061.2
ENST00000627543.2
ENST00000634267.2
dynamin 1
chr10_+_7703300 6.14 ENST00000358415.9
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_9151568 6.14 ENST00000519699.1
protein phosphatase 1 regulatory subunit 3B
chr4_+_40191037 6.10 ENST00000505618.5
ras homolog family member H
chrX_+_15749848 6.08 ENST00000479740.5
ENST00000454127.2
carbonic anhydrase 5B
chr9_-_110999458 6.03 ENST00000374430.6
lysophosphatidic acid receptor 1
chr15_+_24856551 5.93 ENST00000400097.5
small nuclear ribonucleoprotein polypeptide N
chr9_-_111038425 5.91 ENST00000441240.1
ENST00000683809.1
lysophosphatidic acid receptor 1
chr3_+_38305936 5.75 ENST00000273173.4
solute carrier family 22 member 14
chr6_+_29587455 5.64 ENST00000383640.4
olfactory receptor family 2 subfamily H member 2
chr16_+_57735723 5.55 ENST00000562592.5
ENST00000379661.8
ENST00000566726.5
katanin regulatory subunit B1
chr1_-_31764333 5.53 ENST00000398542.5
ENST00000373658.8
adhesion G protein-coupled receptor B2
chr17_-_8118489 5.52 ENST00000380149.6
ENST00000448843.7
arachidonate lipoxygenase 3
chr14_-_106593319 5.52 ENST00000390627.3
immunoglobulin heavy variable 3-53
chr15_-_21718245 5.41 ENST00000630556.1
novel gene identicle to IGHV1OR15-1
chr15_+_80441229 5.38 ENST00000533983.5
ENST00000527771.5
ENST00000525103.1
aryl hydrocarbon receptor nuclear translocator 2
chr1_+_158931539 5.35 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
pyrin and HIN domain family member 1
chr11_+_128693887 5.30 ENST00000281428.12
Fli-1 proto-oncogene, ETS transcription factor
chr16_-_66552460 5.06 ENST00000678015.1
ENST00000569718.6
ENST00000678314.1
ENST00000562484.2
thymidine kinase 2
chr4_+_155758990 5.03 ENST00000505154.5
ENST00000652626.1
ENST00000502959.5
ENST00000264424.13
ENST00000505764.5
ENST00000507146.5
ENST00000503520.5
guanylate cyclase 1 soluble subunit beta 1
chr14_-_106511856 5.02 ENST00000390622.2
immunoglobulin heavy variable 1-46
chr1_+_161505438 5.00 ENST00000271450.12
Fc fragment of IgG receptor IIa
chr3_+_319683 4.98 ENST00000620033.4
cell adhesion molecule L1 like
chr7_-_38249572 4.96 ENST00000436911.6
T cell receptor gamma constant 2
chr2_+_172928165 4.93 ENST00000535187.5
Rap guanine nucleotide exchange factor 4
chr17_-_35880350 4.92 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
C-C motif chemokine ligand 5
chr19_-_51028015 4.90 ENST00000319720.11
kallikrein related peptidase 11
chr19_+_18683656 4.90 ENST00000338797.10
ENST00000321949.13
CREB regulated transcription coactivator 1
chr7_-_80922354 4.80 ENST00000419255.6
semaphorin 3C
chr3_-_49422429 4.70 ENST00000637682.1
ENST00000427987.6
ENST00000636199.1
ENST00000638063.1
ENST00000636865.1
ENST00000458307.6
ENST00000273588.9
ENST00000635808.1
ENST00000636522.1
ENST00000636597.1
ENST00000538581.6
ENST00000395338.7
ENST00000462048.2
aminomethyltransferase
chr14_-_106622837 4.67 ENST00000390628.3
immunoglobulin heavy variable 1-58
chr15_+_43593054 4.61 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
creatine kinase, mitochondrial 1B
chr8_+_38901218 4.51 ENST00000521746.5
ENST00000616927.4
pleckstrin homology domain containing A2
chr7_+_139778229 4.47 ENST00000425687.5
ENST00000650822.1
ENST00000416849.6
ENST00000438104.6
ENST00000336425.10
thromboxane A synthase 1
chr15_-_58014097 4.44 ENST00000559517.5
aldehyde dehydrogenase 1 family member A2
chr5_+_140806929 4.33 ENST00000378125.4
ENST00000618834.1
ENST00000530339.2
ENST00000512229.6
ENST00000672575.1
protocadherin alpha 4
chr19_-_45178200 4.26 ENST00000592647.1
ENST00000006275.8
ENST00000588062.5
ENST00000585934.1
trafficking protein particle complex 6A
chr1_-_13285154 4.24 ENST00000357367.6
ENST00000614831.1
PRAME family member 8
chr3_+_138187511 4.21 ENST00000461822.5
ENST00000485396.5
ENST00000471453.5
ENST00000470821.5
ENST00000471709.5
ENST00000463485.5
armadillo repeat containing 8
chr14_-_105987068 4.19 ENST00000390594.3
immunoglobulin heavy variable 1-2
chr1_+_52404591 4.14 ENST00000257181.10
pre-mRNA processing factor 38A
chr2_+_101998955 4.09 ENST00000393414.6
interleukin 1 receptor type 2
chr20_-_1491407 4.08 ENST00000359801.8
signal regulatory protein beta 2
chr15_-_89211803 4.07 ENST00000563254.1
retinaldehyde binding protein 1
chr5_+_141421064 4.06 ENST00000518882.2
protocadherin gamma subfamily A, 11
chr6_-_159000174 3.99 ENST00000367069.7
radial spoke head 3
chr8_-_90082871 3.97 ENST00000265431.7
calbindin 1
chr15_-_19965101 3.84 ENST00000338912.5
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr6_-_49744434 3.83 ENST00000433368.6
ENST00000354620.4
cysteine rich secretory protein 3
chr22_-_36507022 3.79 ENST00000216187.10
ENST00000397224.9
ENST00000423980.1
FAD dependent oxidoreductase domain containing 2
chr6_-_136466858 3.79 ENST00000544465.5
microtubule associated protein 7
chr1_-_12831410 3.76 ENST00000619922.1
PRAME family member 11
chr12_-_101830799 3.75 ENST00000549940.5
ENST00000392919.4
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr13_-_48413105 3.68 ENST00000620633.5
lysophosphatidic acid receptor 6
chr8_-_94208548 3.63 ENST00000027335.8
ENST00000441892.6
ENST00000521491.1
cadherin 17
chr18_-_55586092 3.58 ENST00000563888.6
ENST00000540999.5
ENST00000627685.2
transcription factor 4
chr2_+_113058637 3.57 ENST00000346807.7
interleukin 36 receptor antagonist
chr4_-_47981535 3.53 ENST00000402813.9
cyclic nucleotide gated channel subunit alpha 1
chrX_+_101219917 3.53 ENST00000541709.5
dystrophin related protein 2
chr5_+_55160161 3.53 ENST00000296734.6
ENST00000515370.1
ENST00000503787.6
glutathione peroxidase 8 (putative)
chr10_-_1737516 3.38 ENST00000381312.6
adenosine deaminase RNA specific B2 (inactive)
chr9_+_126914760 3.35 ENST00000424082.6
ENST00000259351.10
ENST00000394022.7
ENST00000394011.7
ENST00000319107.8
Ral GEF with PH domain and SH3 binding motif 1
chr15_+_62561361 3.35 ENST00000561311.5
talin 2
chr3_-_179071742 3.28 ENST00000311417.7
ENST00000652290.1
zinc finger matrin-type 3
chr12_+_55932028 3.28 ENST00000394147.5
ENST00000551156.5
ENST00000553783.5
ENST00000557080.5
ENST00000432422.7
ENST00000556001.5
diacylglycerol kinase alpha
chr8_+_2045037 3.23 ENST00000262113.9
myomesin 2
chr3_-_186570308 3.20 ENST00000446782.5
TBCC domain containing 1
chr4_+_77605807 3.20 ENST00000682537.1
C-X-C motif chemokine ligand 13
chr19_+_51225059 3.19 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33 molecule
chrX_-_49073989 3.16 ENST00000376386.3
ENST00000553851.3
PRA1 domain family member 2
chr1_+_67307360 3.14 ENST00000262345.5
ENST00000544434.5
interleukin 12 receptor subunit beta 2
chr6_-_49744378 3.13 ENST00000371159.8
ENST00000263045.9
cysteine rich secretory protein 3
chr17_-_75667165 3.11 ENST00000584999.1
ENST00000420326.6
ENST00000340830.9
RecQ like helicase 5
chr18_-_55585773 3.06 ENST00000563824.5
ENST00000626425.2
ENST00000566514.5
ENST00000568673.5
ENST00000562847.5
ENST00000568147.5
transcription factor 4
chr12_-_101830671 3.01 ENST00000549165.1
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr8_+_109362453 3.01 ENST00000378402.10
PKHD1 like 1
chr5_-_161546671 3.00 ENST00000517547.5
gamma-aminobutyric acid type A receptor subunit beta2
chr14_-_106277039 3.00 ENST00000390610.2
immunoglobulin heavy variable 1-24
chr3_+_138187248 2.97 ENST00000538260.5
ENST00000481646.5
ENST00000491704.5
ENST00000469044.6
ENST00000461600.5
ENST00000466749.5
ENST00000358441.6
ENST00000489213.5
armadillo repeat containing 8
chr10_-_20897288 2.94 ENST00000377122.9
nebulette
chrX_+_13569593 2.93 ENST00000361306.6
ENST00000380602.3
EGF like domain multiple 6
chr1_+_70411241 2.93 ENST00000370938.8
ENST00000346806.2
cystathionine gamma-lyase
chr11_-_129192198 2.90 ENST00000310343.13
Rho GTPase activating protein 32
chr10_-_72354895 2.90 ENST00000444643.8
ENST00000338820.7
ENST00000394903.6
DnaJ heat shock protein family (Hsp40) member B12
chr3_-_58211212 2.89 ENST00000461914.7
deoxyribonuclease 1 like 3
chr4_+_6693870 2.85 ENST00000296370.4
S100 calcium binding protein P
chr1_+_18630839 2.82 ENST00000420770.7
paired box 7
chr10_+_95756150 2.81 ENST00000371205.5
ectonucleoside triphosphate diphosphohydrolase 1
chr4_-_99435336 2.80 ENST00000437033.7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr7_-_83649097 2.80 ENST00000643230.2
semaphorin 3E
chr8_+_106726012 2.79 ENST00000449762.6
ENST00000297447.10
oxidation resistance 1
chr12_+_55931148 2.78 ENST00000549629.5
ENST00000555218.5
ENST00000331886.10
diacylglycerol kinase alpha
chr6_-_132757883 2.78 ENST00000525289.5
ENST00000326499.11
vanin 2
chr16_+_87951424 2.73 ENST00000439677.5
ENST00000286122.11
ENST00000454563.5
ENST00000479780.6
ENST00000682872.1
ENST00000393208.6
ENST00000412691.5
ENST00000626016.2
ENST00000355022.8
BTG3 associated nuclear protein
chr12_-_9607903 2.73 ENST00000229402.4
killer cell lectin like receptor B1
chr6_-_52803807 2.72 ENST00000334575.6
glutathione S-transferase alpha 1
chr3_-_38794042 2.72 ENST00000643924.1
sodium voltage-gated channel alpha subunit 10
chr4_+_70383123 2.71 ENST00000304915.8
submaxillary gland androgen regulated protein 3B
chr8_+_22995831 2.69 ENST00000522948.5
Rho related BTB domain containing 2
chr4_-_99435396 2.63 ENST00000209665.8
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr10_-_118342292 2.61 ENST00000369172.8
ENST00000369183.9
family with sequence similarity 204 member A
chr2_+_64989343 2.58 ENST00000234256.4
solute carrier family 1 member 4
chr16_+_21233672 2.54 ENST00000311620.7
ankyrin repeat and sterile alpha motif domain containing 4B
chr18_+_63775395 2.51 ENST00000398019.7
serpin family B member 7
chr4_+_95051671 2.51 ENST00000440890.7
bone morphogenetic protein receptor type 1B
chr5_-_161546708 2.50 ENST00000393959.6
gamma-aminobutyric acid type A receptor subunit beta2
chr4_-_10684749 2.46 ENST00000226951.11
cytokine dependent hematopoietic cell linker
chr22_-_29388530 2.46 ENST00000357586.7
ENST00000432560.6
ENST00000405198.6
ENST00000317368.11
adaptor related protein complex 1 subunit beta 1
chr5_-_22853320 2.46 ENST00000504376.6
ENST00000382254.6
cadherin 12
chr10_-_6062290 2.42 ENST00000256876.10
ENST00000379954.5
interleukin 2 receptor subunit alpha
chr6_+_31739948 2.39 ENST00000375755.8
ENST00000425703.5
ENST00000375750.9
ENST00000375703.7
ENST00000375740.7
mutS homolog 5
chr3_+_40100007 2.39 ENST00000539167.2
myosin VIIA and Rab interacting protein
chr4_-_38856807 2.39 ENST00000506146.5
ENST00000436693.6
ENST00000508254.5
ENST00000514655.1
toll like receptor 1
toll like receptor 6
chr22_+_22720615 2.38 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr6_+_101181254 2.37 ENST00000682090.1
ENST00000421544.6
glutamate ionotropic receptor kainate type subunit 2
chr1_-_13201409 2.33 ENST00000625019.3
PRAME family member 13
chr11_+_17260353 2.27 ENST00000530527.5
nucleobindin 2
chr2_-_166128004 2.24 ENST00000303395.9
ENST00000674923.1
ENST00000637988.1
ENST00000635776.1
sodium voltage-gated channel alpha subunit 1
chr17_-_64263221 2.20 ENST00000258991.7
ENST00000583738.1
ENST00000584379.6
testis expressed 2
chr17_-_40565459 2.20 ENST00000578085.1
ENST00000246657.2
C-C motif chemokine receptor 7
chr19_-_7747511 2.18 ENST00000593660.5
ENST00000204801.12
ENST00000315591.12
ENST00000354397.10
ENST00000394161.9
ENST00000593821.5
ENST00000602261.5
ENST00000601256.1
ENST00000601951.5
ENST00000315599.12
CD209 molecule
chr5_-_180072086 2.15 ENST00000261947.4
ring finger protein 130
chr17_+_7484357 2.14 ENST00000674977.2
RNA polymerase II subunit A
chr2_+_203867943 2.13 ENST00000295854.10
ENST00000487393.1
ENST00000472206.1
cytotoxic T-lymphocyte associated protein 4
chr8_+_2045058 2.08 ENST00000523438.1
myomesin 2
chr2_+_203867764 2.01 ENST00000648405.2
cytotoxic T-lymphocyte associated protein 4
chr11_+_10456186 1.99 ENST00000528723.5
adenosine monophosphate deaminase 3
chr4_+_55346213 1.98 ENST00000679836.1
ENST00000264228.9
ENST00000679707.1
steroid 5 alpha-reductase 3
novel protein, SRD5A3-RP11-177J6.1 readthrough
chr5_+_141421020 1.98 ENST00000622044.1
ENST00000398587.7
protocadherin gamma subfamily A, 11
chr4_-_144140683 1.96 ENST00000324022.14
glycophorin A (MNS blood group)
chr1_-_12886201 1.96 ENST00000235349.6
PRAME family member 4
chr12_-_9999176 1.93 ENST00000298527.10
ENST00000348658.4
C-type lectin domain family 1 member B
chr6_-_41736239 1.86 ENST00000358871.6
transcription factor EB
chr6_+_27810041 1.85 ENST00000369163.3
H3 clustered histone 10
chr19_+_48552159 1.84 ENST00000201586.7
sulfotransferase family 2B member 1
chr12_+_29223730 1.84 ENST00000547116.5
fatty acyl-CoA reductase 2
chr1_-_48472166 1.83 ENST00000371847.8
ENST00000396199.7
spermatogenesis associated 6
chrX_-_133753681 1.81 ENST00000406757.2
glypican 3
chr4_-_16084002 1.78 ENST00000447510.7
prominin 1
chr3_-_21751189 1.76 ENST00000281523.8
zinc finger protein 385D
chr5_-_95081482 1.76 ENST00000312216.12
ENST00000512425.5
ENST00000505208.5
ENST00000429576.6
ENST00000508509.5
ENST00000510732.5
multiple C2 and transmembrane domain containing 1
chr16_+_30375820 1.71 ENST00000566955.1
myosin light chain, phosphorylatable, fast skeletal muscle
chr5_+_175861628 1.66 ENST00000509837.5
complexin 2
chr5_-_161546970 1.66 ENST00000675303.1
gamma-aminobutyric acid type A receptor subunit beta2
chr13_-_49413749 1.66 ENST00000610540.4
ENST00000347776.9
ENST00000409082.5
calcium binding protein 39 like
chr10_+_38094327 1.62 ENST00000638053.1
ENST00000351773.7
ENST00000361085.9
zinc finger protein 37A
chr15_-_30991415 1.59 ENST00000563714.5
myotubularin related protein 10
chr12_-_21775581 1.58 ENST00000537950.1
ENST00000665145.1
potassium inwardly rectifying channel subfamily J member 8

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 15.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
3.1 9.4 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
3.1 9.4 GO:0071461 cellular response to redox state(GO:0071461)
2.4 11.9 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
2.3 6.8 GO:0016256 N-glycan processing to lysosome(GO:0016256)
2.2 2.2 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
2.1 6.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
2.0 8.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
2.0 18.1 GO:0072564 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
1.9 7.6 GO:0061528 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
1.9 5.6 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
1.7 15.5 GO:0001661 conditioned taste aversion(GO:0001661)
1.6 4.9 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
1.6 24.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
1.6 8.0 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.5 10.4 GO:0070560 protein secretion by platelet(GO:0070560)
1.5 8.7 GO:0016926 protein desumoylation(GO:0016926)
1.4 5.8 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.3 9.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
1.2 11.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
1.2 3.6 GO:0033625 germinal center B cell differentiation(GO:0002314) positive regulation of integrin activation(GO:0033625)
1.1 3.3 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
1.1 7.6 GO:0060267 positive regulation of respiratory burst(GO:0060267)
1.1 3.2 GO:0051684 maintenance of Golgi location(GO:0051684)
1.1 5.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
1.0 69.5 GO:0006910 phagocytosis, recognition(GO:0006910)
1.0 4.1 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.9 2.8 GO:0014813 skeletal muscle satellite cell commitment(GO:0014813)
0.9 4.7 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.9 3.7 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.8 5.1 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.8 12.6 GO:0001778 plasma membrane repair(GO:0001778)
0.8 4.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.8 4.8 GO:0003350 pulmonary myocardium development(GO:0003350)
0.8 2.4 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.8 3.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.8 10.0 GO:2000394 phosphatidylcholine catabolic process(GO:0034638) positive regulation of lamellipodium morphogenesis(GO:2000394)
0.7 9.7 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.7 4.3 GO:1903232 melanosome assembly(GO:1903232)
0.7 5.5 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.6 8.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.6 4.4 GO:2000698 positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.6 1.8 GO:0000103 sulfate assimilation(GO:0000103)
0.6 8.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.6 6.5 GO:0042908 xenobiotic transport(GO:0042908)
0.6 2.9 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.5 2.2 GO:0046968 peptide antigen transport(GO:0046968)
0.5 12.4 GO:0035855 megakaryocyte development(GO:0035855)
0.5 2.6 GO:0015808 L-alanine transport(GO:0015808)
0.5 2.5 GO:1904970 brush border assembly(GO:1904970)
0.5 4.0 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.5 2.0 GO:0016095 polyprenol catabolic process(GO:0016095)
0.5 1.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.5 2.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.5 6.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.5 7.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.5 1.8 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.4 3.6 GO:0019732 antifungal humoral response(GO:0019732)
0.4 1.3 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.4 9.4 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.4 14.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.4 7.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.4 2.5 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.3 2.0 GO:0006196 AMP catabolic process(GO:0006196)
0.3 1.0 GO:1901876 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.3 7.9 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.3 1.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.3 7.5 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.3 2.4 GO:0051026 chiasma assembly(GO:0051026)
0.3 7.2 GO:0071420 cellular response to histamine(GO:0071420)
0.3 7.6 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.3 6.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 4.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 2.7 GO:0086043 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.2 2.8 GO:0015939 pantothenate metabolic process(GO:0015939)
0.2 8.2 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.2 3.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 2.9 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.2 3.8 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.2 1.1 GO:0052805 histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.2 3.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 2.8 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.2 5.8 GO:0015695 organic cation transport(GO:0015695)
0.2 17.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 2.2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.2 5.0 GO:0035640 exploration behavior(GO:0035640)
0.2 2.4 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 16.8 GO:0031295 T cell costimulation(GO:0031295)
0.2 1.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 2.7 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 2.8 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.1 2.9 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 4.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 0.7 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 7.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 7.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 0.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 6.1 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2.8 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 3.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 1.6 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 6.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 4.7 GO:0007618 mating(GO:0007618)
0.1 0.9 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1 0.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 1.2 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 3.2 GO:0015813 L-glutamate transport(GO:0015813)
0.1 3.9 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.7 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 6.7 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 3.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 1.8 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.7 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 2.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 1.9 GO:0030220 platelet formation(GO:0030220)
0.1 5.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 9.7 GO:0002377 immunoglobulin production(GO:0002377)
0.1 4.9 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 3.1 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 19.9 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 7.2 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 1.5 GO:0050832 defense response to fungus(GO:0050832)
0.0 2.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 5.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.0 12.1 GO:0002250 adaptive immune response(GO:0002250)
0.0 3.8 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 5.4 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 3.5 GO:1990748 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.6 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 4.5 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 5.5 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.5 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 1.3 GO:0001938 positive regulation of endothelial cell proliferation(GO:0001938)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 2.2 GO:0043542 endothelial cell migration(GO:0043542)
0.0 3.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.5 GO:0050808 synapse organization(GO:0050808)
0.0 0.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.7 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 1.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 1.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.3 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.0 1.5 GO:0007286 spermatid development(GO:0007286)
0.0 4.4 GO:0050900 leukocyte migration(GO:0050900)
0.0 0.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.4 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.9 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.7 GO:0090630 activation of GTPase activity(GO:0090630)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
2.5 7.6 GO:0071754 dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752) IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
1.9 9.7 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
1.9 15.5 GO:0035976 AP1 complex(GO:0035976)
1.9 7.6 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
1.1 53.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.9 16.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.8 7.5 GO:0033391 chromatoid body(GO:0033391)
0.8 2.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.6 8.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.6 11.7 GO:0016461 unconventional myosin complex(GO:0016461)
0.6 1.8 GO:0097224 sperm connecting piece(GO:0097224)
0.6 6.1 GO:0042587 glycogen granule(GO:0042587)
0.5 18.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 8.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.4 10.4 GO:0031095 spectrin-associated cytoskeleton(GO:0014731) platelet dense tubular network membrane(GO:0031095)
0.4 5.9 GO:0005687 U4 snRNP(GO:0005687)
0.4 4.3 GO:0030008 TRAPP complex(GO:0030008)
0.4 1.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.3 2.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.3 1.7 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.2 5.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 5.3 GO:0032982 myosin filament(GO:0032982)
0.2 11.8 GO:0043198 dendritic shaft(GO:0043198)
0.2 2.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 7.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 12.6 GO:0030315 T-tubule(GO:0030315)
0.2 4.1 GO:0071011 precatalytic spliceosome(GO:0071011)
0.2 1.2 GO:1990635 proximal dendrite(GO:1990635)
0.2 20.9 GO:0005901 caveola(GO:0005901)
0.2 3.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 2.1 GO:0000974 Prp19 complex(GO:0000974)
0.2 2.9 GO:0031528 microvillus membrane(GO:0031528)
0.2 7.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 8.5 GO:0005871 kinesin complex(GO:0005871)
0.1 2.4 GO:0000145 exocyst(GO:0000145)
0.1 6.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 8.6 GO:0001772 immunological synapse(GO:0001772)
0.1 3.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 19.1 GO:0072562 blood microparticle(GO:0072562)
0.1 2.0 GO:0032300 mismatch repair complex(GO:0032300)
0.1 8.6 GO:0035580 specific granule lumen(GO:0035580)
0.1 1.7 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.7 GO:0072487 MSL complex(GO:0072487)
0.1 4.1 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.1 3.9 GO:0001533 cornified envelope(GO:0001533)
0.1 1.0 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.1 2.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 3.4 GO:0005902 microvillus(GO:0005902)
0.1 7.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 4.0 GO:0043195 terminal bouton(GO:0043195)
0.0 2.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.5 GO:0071564 SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)
0.0 13.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.6 GO:0000922 spindle pole(GO:0000922)
0.0 6.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 8.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.9 GO:0030018 Z disc(GO:0030018)
0.0 7.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.6 GO:0005882 intermediate filament(GO:0005882)
0.0 3.1 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 5.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 7.5 GO:0030424 axon(GO:0030424)
0.0 84.7 GO:0016021 integral component of membrane(GO:0016021)
0.0 3.8 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.8 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
2.5 10.0 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
2.3 18.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.9 7.6 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
1.7 8.7 GO:0019862 IgA binding(GO:0019862)
1.7 6.8 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
1.6 8.0 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.6 4.7 GO:0004047 aminomethyltransferase activity(GO:0004047)
1.5 4.5 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
1.5 8.7 GO:0016929 SUMO-specific protease activity(GO:0016929)
1.4 5.8 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
1.4 15.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
1.4 4.1 GO:0005502 11-cis retinal binding(GO:0005502)
1.2 2.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
1.2 9.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.2 16.2 GO:0032395 MHC class II receptor activity(GO:0032395)
1.1 3.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.1 3.3 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
1.1 5.5 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
1.0 4.9 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.0 9.7 GO:0001851 complement component C3b binding(GO:0001851)
0.9 53.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.8 4.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.8 5.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.8 15.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.7 3.6 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.7 6.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.7 5.1 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.7 7.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.7 3.6 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.7 2.8 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.7 2.0 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.6 3.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.6 1.8 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.6 2.4 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.6 4.0 GO:0005499 vitamin D binding(GO:0005499)
0.5 7.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.5 1.6 GO:0004967 glucagon receptor activity(GO:0004967)
0.5 9.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.5 3.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.5 2.6 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.5 7.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 4.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.4 5.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.4 6.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 7.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 6.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 29.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 4.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 5.8 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.3 6.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 11.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 3.5 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.3 5.0 GO:0019864 IgG binding(GO:0019864)
0.3 1.4 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.3 6.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.3 7.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 1.6 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.3 2.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 1.8 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.3 25.2 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.2 1.0 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 5.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.2 39.5 GO:0003823 antigen binding(GO:0003823)
0.2 6.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 7.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 2.0 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 3.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.2 2.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 2.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 7.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.2 26.8 GO:0008565 protein transporter activity(GO:0008565)
0.2 1.8 GO:0032027 myosin light chain binding(GO:0032027)
0.2 2.8 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.2 10.4 GO:0030507 spectrin binding(GO:0030507)
0.2 2.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 0.6 GO:0005148 prolactin receptor binding(GO:0005148)
0.2 7.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 16.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 5.0 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 20.2 GO:0003774 motor activity(GO:0003774)
0.1 1.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.5 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 2.9 GO:0031005 filamin binding(GO:0031005)
0.1 12.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 2.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 4.4 GO:0042805 actinin binding(GO:0042805)
0.1 7.5 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 2.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.7 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 1.0 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 7.7 GO:0002039 p53 binding(GO:0002039)
0.1 4.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.0 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 2.8 GO:0030552 cAMP binding(GO:0030552)
0.1 6.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 3.8 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 2.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 1.2 GO:0070402 NADPH binding(GO:0070402)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 3.8 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 2.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 4.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 4.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 7.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 17.4 GO:0004888 transmembrane signaling receptor activity(GO:0004888)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 15.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.6 12.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 18.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 14.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 9.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 14.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 6.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.2 12.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 7.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 9.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 11.9 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 4.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 26.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.1 PID IL1 PATHWAY IL1-mediated signaling events
0.1 3.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 3.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 3.1 PID IL27 PATHWAY IL27-mediated signaling events
0.1 7.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 4.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 19.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.3 PID AP1 PATHWAY AP-1 transcription factor network
0.1 6.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 3.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.5 PID BMP PATHWAY BMP receptor signaling
0.0 3.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 2.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.8 22.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.8 16.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6 5.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 7.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 6.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.3 6.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 2.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 3.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 7.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 7.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 32.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 18.1 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.2 10.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 7.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 5.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 5.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.5 REACTOME DEFENSINS Genes involved in Defensins
0.1 7.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 6.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 23.0 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 2.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 2.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 9.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 7.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 4.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 2.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 0.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.6 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 1.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins