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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SP100

Z-value: 8.35

Motif logo

Transcription factors associated with SP100

Gene Symbol Gene ID Gene Info
ENSG00000067066.17 SP100

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SP100hg38_v1_chr2_+_230416156_2304161860.314.1e-06Click!

Activity profile of SP100 motif

Sorted Z-values of SP100 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SP100

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr16_-_69726506 37.75 ENST00000561500.5
ENST00000320623.10
ENST00000439109.6
ENST00000564043.1
ENST00000379046.6
ENST00000379047.7
NAD(P)H quinone dehydrogenase 1
chr11_+_35180342 37.29 ENST00000639002.1
CD44 molecule (Indian blood group)
chr12_+_27710795 33.80 ENST00000081029.8
ENST00000538315.5
ENST00000542791.1
mitochondrial ribosomal protein S35
chr15_+_66504959 28.60 ENST00000535141.6
ENST00000613446.4
ENST00000446801.6
zwilch kinetochore protein
chr15_+_66505289 27.83 ENST00000565627.5
ENST00000564179.5
ENST00000307897.10
zwilch kinetochore protein
chrX_+_120604199 26.49 ENST00000371315.3
MCTS1 re-initiation and release factor
chr1_-_86914102 25.08 ENST00000331835.10
ENST00000401030.4
ENST00000370554.5
selenoprotein F
chr7_+_118184156 24.43 ENST00000422760.1
ENST00000249299.7
ENST00000411938.1
LSM8 homolog, U6 small nuclear RNA associated
chr1_+_236394268 24.30 ENST00000334232.9
EDAR associated death domain
chr16_-_30429800 23.85 ENST00000568973.5
ENST00000678016.1
ENST00000565758.1
ENST00000319285.5
ENST00000567983.1
dCTP pyrophosphatase 1
chr11_+_35180279 23.75 ENST00000531873.5
CD44 molecule (Indian blood group)
chrX_-_77969638 23.57 ENST00000458128.3
phosphoglycerate mutase family member 4
chr1_-_225428813 23.49 ENST00000338179.6
ENST00000425080.1
lamin B receptor
chr5_+_33440947 23.41 ENST00000455217.6
ENST00000265112.8
threonyl-tRNA synthetase 1
chr5_+_138179093 22.47 ENST00000394894.8
kinesin family member 20A
chrX_+_120604084 22.40 ENST00000371317.10
MCTS1 re-initiation and release factor
chr1_-_86914319 21.76 ENST00000611507.4
ENST00000616787.4
selenoprotein F
chr14_+_58244821 21.49 ENST00000216455.9
ENST00000412908.6
ENST00000557508.5
proteasome 20S subunit alpha 3
chr12_+_103930332 21.41 ENST00000681861.1
ENST00000550595.2
ENST00000680762.1
ENST00000614327.2
ENST00000681949.1
ENST00000299767.10
heat shock protein 90 beta family member 1
chr20_-_5126534 21.39 ENST00000379160.3
proliferating cell nuclear antigen
chr3_+_142623386 21.24 ENST00000337777.7
ENST00000497199.5
plastin 1
chr7_-_100100716 20.12 ENST00000354230.7
ENST00000425308.5
minichromosome maintenance complex component 7
chr14_-_54441325 20.06 ENST00000556113.1
ENST00000553660.5
ENST00000216416.9
ENST00000395573.8
ENST00000557690.5
cornichon family AMPA receptor auxiliary protein 1
chr1_-_63523175 19.92 ENST00000371092.7
ENST00000271002.15
integrin subunit beta 3 binding protein
chr5_+_33440696 19.47 ENST00000502553.5
ENST00000514259.5
threonyl-tRNA synthetase 1
chr5_+_138179145 19.01 ENST00000508792.5
ENST00000504621.1
kinesin family member 20A
chr1_-_108192818 18.40 ENST00000370041.4
solute carrier family 25 member 24
chr12_-_120446372 18.15 ENST00000546954.2
TP53 regulated inhibitor of apoptosis 1
chr3_-_64023986 18.14 ENST00000394431.6
proteasome 26S subunit, non-ATPase 6
chrX_+_78104229 17.74 ENST00000373316.5
phosphoglycerate kinase 1
chr11_+_119087979 17.57 ENST00000535253.5
ENST00000392841.1
ENST00000648374.1
hydroxymethylbilane synthase
chr3_+_180912444 17.24 ENST00000305586.11
FMR1 autosomal homolog 1
chr12_-_47705971 17.04 ENST00000380650.4
RNA polymerase II associated protein 3
chr2_+_171922442 16.86 ENST00000264108.5
histone acetyltransferase 1
chr7_+_99374240 16.76 ENST00000443222.6
ENST00000414376.5
actin related protein 2/3 complex subunit 1B
chr2_+_200305873 16.76 ENST00000439084.5
ENST00000409718.5
spermatogenesis associated serine rich 2 like
chr15_+_59105099 16.74 ENST00000288207.7
ENST00000559622.5
cyclin B2
chr17_-_59707404 16.62 ENST00000393038.3
peptidyl-tRNA hydrolase 2
chr5_-_126595237 16.45 ENST00000637206.1
ENST00000553117.5
aldehyde dehydrogenase 7 family member A1
chr7_-_92134737 16.11 ENST00000450723.5
cytochrome P450 family 51 subfamily A member 1
chr16_-_46621345 16.03 ENST00000303383.8
SHC binding and spindle associated 1
chr1_-_155934398 16.00 ENST00000368320.7
ENST00000368321.8
KH domain containing 4, pre-mRNA splicing factor
chr2_-_196799642 15.94 ENST00000409364.3
ENST00000263956.8
general transcription factor IIIC subunit 3
chr3_-_32502783 15.93 ENST00000205636.4
CKLF like MARVEL transmembrane domain containing 6
chr9_+_33265013 15.81 ENST00000223500.9
charged multivesicular body protein 5
chr12_+_103930600 15.56 ENST00000680316.1
ENST00000679861.1
heat shock protein 90 beta family member 1
chr15_-_78299570 15.49 ENST00000560569.5
ENST00000558459.5
ENST00000558311.5
ENST00000267973.7
WD repeat domain 61
chr14_-_102139645 15.11 ENST00000334701.11
ENST00000558600.1
heat shock protein 90 alpha family class A member 1
chr2_+_201129318 15.10 ENST00000417748.1
CASP8 and FADD like apoptosis regulator
chr2_+_200306048 15.04 ENST00000409988.7
ENST00000409385.5
spermatogenesis associated serine rich 2 like
chr5_+_136049513 15.04 ENST00000514554.5
transforming growth factor beta induced
chr2_-_151289613 14.93 ENST00000243346.10
N-myc and STAT interactor
chr22_+_23966880 14.85 ENST00000215770.6
D-dopachrome tautomerase like
chr1_+_44739825 14.55 ENST00000372224.9
kinesin family member 2C
chr15_+_59105205 14.16 ENST00000621385.1
cyclin B2
chr11_-_6683282 14.12 ENST00000532203.1
ENST00000288937.7
mitochondrial ribosomal protein L17
chr22_-_23974441 13.96 ENST00000398344.9
ENST00000403754.7
ENST00000430101.2
D-dopachrome tautomerase
chrX_+_119574554 13.94 ENST00000371558.7
ENST00000630695.2
ENST00000631185.2
ubiquitin conjugating enzyme E2 A
chr9_-_125650417 13.94 ENST00000420643.5
MAPK associated protein 1
chr10_-_89414458 13.77 ENST00000371837.5
lipase A, lysosomal acid type
chrX_-_15493234 13.75 ENST00000380420.10
pirin
chr15_-_66504832 13.72 ENST00000569438.2
ENST00000569696.5
ENST00000307961.11
ribosomal protein L4
chr10_+_113679159 13.70 ENST00000621345.4
ENST00000429617.5
ENST00000369331.8
caspase 7
chrX_+_77899440 13.70 ENST00000373335.4
ENST00000475465.1
ENST00000650309.2
ENST00000647835.1
cytochrome c oxidase subunit 7B
chr9_+_33264848 13.60 ENST00000419016.6
charged multivesicular body protein 5
chr1_-_1407237 13.49 ENST00000482352.1
ENST00000344843.12
mitochondrial ribosomal protein L20
chr10_-_73167961 13.42 ENST00000372979.9
ecdysoneless cell cycle regulator
chr2_+_234952009 13.36 ENST00000392011.7
SH3 domain binding protein 4
chr14_+_20469399 13.36 ENST00000361505.10
ENST00000553591.1
purine nucleoside phosphorylase
chr15_-_59657468 13.35 ENST00000396061.5
general transcription factor IIA subunit 2
chrX_+_11111291 13.26 ENST00000321143.8
ENST00000380762.5
ENST00000380763.7
holocytochrome c synthase
chrX_+_119574530 13.20 ENST00000346330.6
ENST00000625938.2
ubiquitin conjugating enzyme E2 A
chr11_-_33722710 13.15 ENST00000415002.7
ENST00000437761.6
ENST00000445143.6
CD59 molecule (CD59 blood group)
chr5_-_69369465 13.11 ENST00000508954.3
ENST00000512152.5
ENST00000503245.5
ENST00000217893.10
ENST00000618980.1
ENST00000502819.5
ENST00000380822.9
ENST00000512561.5
TATA-box binding protein associated factor 9
adenylate kinase 6
chr5_+_151771943 13.10 ENST00000520177.6
ENST00000678854.1
ENST00000520006.2
ENST00000677105.1
ENST00000678101.1
ENST00000678910.1
ENST00000356245.8
ENST00000678646.1
ENST00000677433.1
ENST00000677369.1
ENST00000677284.1
ENST00000678564.1
G3BP stress granule assembly factor 1
chr20_+_31547367 13.09 ENST00000394552.3
MCTS family member 2, pseudogene
chr11_+_86244745 13.09 ENST00000528180.5
ENST00000263360.11
ENST00000672825.1
embryonic ectoderm development
chr11_-_62671540 13.00 ENST00000532208.5
ENST00000377954.3
ENST00000431002.6
ENST00000354588.7
ENST00000415855.6
LBH domain containing 1
chr7_+_55887277 12.94 ENST00000426595.1
novel zinc finger protein 713 (ZNF713) and mitochondrial ribosomal protein S17 (MRPS17) protein
chr14_+_55051639 12.90 ENST00000395468.9
ENST00000622254.1
mitogen-activated protein kinase 1 interacting protein 1 like
chr6_+_31403553 12.87 ENST00000449934.7
ENST00000421350.1
MHC class I polypeptide-related sequence A
chr1_+_84479239 12.87 ENST00000370656.5
ENST00000370654.6
ribosome production factor 1 homolog
chr14_-_75176593 12.79 ENST00000303575.9
transmembrane p24 trafficking protein 10
chrX_-_23907887 12.70 ENST00000379226.9
apolipoprotein O
chr19_+_32581178 12.69 ENST00000590247.7
ENST00000419343.7
ENST00000592786.5
ENST00000379316.3
programmed cell death 5
chr7_+_118184105 12.49 ENST00000424702.1
LSM8 homolog, U6 small nuclear RNA associated
chr21_-_29073565 12.46 ENST00000431234.1
ENST00000286788.9
ENST00000540844.5
chaperonin containing TCP1 subunit 8
chr2_+_199955539 12.44 ENST00000392290.5
matrix AAA peptidase interacting protein 1
chr12_+_56041893 12.39 ENST00000552361.1
ENST00000646449.2
ribosomal protein S26
chr14_-_23034878 12.35 ENST00000493471.2
ENST00000460922.2
ENST00000361611.11
proteasome 20S subunit beta 5
chr1_+_214603173 12.34 ENST00000366955.8
centromere protein F
chr21_+_36135071 12.32 ENST00000290354.6
carbonyl reductase 3
chr5_+_110738983 12.32 ENST00000355943.8
ENST00000447245.6
solute carrier family 25 member 46
chr8_+_103298433 12.28 ENST00000522566.5
frizzled class receptor 6
chr3_+_62319037 12.25 ENST00000494481.5
chromosome 3 open reading frame 14
chr4_+_41935114 12.23 ENST00000508448.5
ENST00000513702.5
ENST00000325094.9
transmembrane protein 33
chr11_+_108665045 12.22 ENST00000322536.8
DEAD-box helicase 10
chr13_+_43023577 12.14 ENST00000379221.4
DnaJ heat shock protein family (Hsp40) member C15
chrX_-_10620419 12.07 ENST00000380782.6
midline 1
chr11_-_78079773 11.94 ENST00000612612.5
ENST00000614236.2
NDUFC2-KCTD14 readthrough
chr20_-_33401501 11.92 ENST00000473997.5
ENST00000346416.7
ENST00000357886.8
ENST00000339269.5
CDK5 regulatory subunit associated protein 1
chr3_-_57597443 11.89 ENST00000463880.1
ADP ribosylation factor 4
chr20_+_43590912 11.85 ENST00000373030.8
ENST00000373039.4
intraflagellar transport 52
chr1_-_93879198 11.77 ENST00000436063.7
deoxynucleotidyltransferase terminal interacting protein 2
chr5_+_151771884 11.74 ENST00000627077.2
ENST00000678976.1
ENST00000677408.1
ENST00000678070.1
ENST00000678964.1
ENST00000678925.1
ENST00000394123.7
ENST00000522761.6
ENST00000676827.1
G3BP stress granule assembly factor 1
chr1_+_161314372 11.73 ENST00000342751.8
ENST00000367975.7
ENST00000432287.6
ENST00000392169.6
ENST00000513009.5
succinate dehydrogenase complex subunit C
chr2_-_10812794 11.71 ENST00000540494.5
protein disulfide isomerase family A member 6
chr12_-_56752311 11.34 ENST00000338193.11
ENST00000550770.1
DNA primase subunit 1
chr6_+_30721573 11.31 ENST00000330914.7
tubulin beta class I
chr6_-_127343590 11.31 ENST00000368291.6
ENST00000454859.8
ethylmalonyl-CoA decarboxylase 1
chr5_-_77776321 11.26 ENST00000380377.9
tubulin folding cofactor A
chr1_+_75724431 11.07 ENST00000541113.6
ENST00000680805.1
acyl-CoA dehydrogenase medium chain
chrX_-_136880715 11.07 ENST00000431446.7
ENST00000320676.11
ENST00000562646.5
RNA binding motif protein X-linked
chr15_-_90234046 11.00 ENST00000612800.1
calcium and integrin binding 1
chr15_-_59657494 11.00 ENST00000396063.5
ENST00000396060.7
ENST00000396064.7
ENST00000484743.5
ENST00000559706.1
general transcription factor IIA subunit 2
chr5_+_32585549 11.00 ENST00000265073.9
ENST00000515355.5
ENST00000502897.5
ENST00000510442.1
SUB1 regulator of transcription
chr19_-_14517425 10.90 ENST00000676577.1
ENST00000677204.1
ENST00000598235.2
DnaJ heat shock protein family (Hsp40) member B1
chr12_-_32755876 10.89 ENST00000324868.13
tyrosyl-tRNA synthetase 2
chr14_-_23035223 10.87 ENST00000425762.2
proteasome 20S subunit beta 5
chr2_-_55269207 10.86 ENST00000263629.9
ENST00000403721.5
mitochondrial translational initiation factor 2
chr2_-_55917699 10.82 ENST00000634374.1
EGF containing fibulin extracellular matrix protein 1
chr18_+_3247778 10.77 ENST00000217652.8
ENST00000578611.5
ENST00000583449.1
myosin light chain 12A
chr8_-_101204697 10.76 ENST00000517844.5
zinc finger protein 706
chr22_-_27919199 10.58 ENST00000634017.1
ENST00000436663.1
ENST00000320996.14
ENST00000335272.10
ENST00000455418.7
phosphatidylinositol transfer protein beta
chr17_-_782317 10.42 ENST00000301329.10
glyoxalase domain containing 4
chr6_-_127343518 10.42 ENST00000528402.5
ENST00000454591.6
ethylmalonyl-CoA decarboxylase 1
chrX_+_48897900 10.38 ENST00000376566.8
ENST00000376563.5
polyglutamine binding protein 1
chr4_+_168497066 10.34 ENST00000261509.10
palladin, cytoskeletal associated protein
chr6_+_30721624 10.29 ENST00000396389.5
ENST00000396384.1
tubulin beta class I
chr10_+_78033760 10.26 ENST00000435275.5
ENST00000613865.5
ENST00000645440.1
ENST00000464716.6
ENST00000360830.9
ENST00000372360.9
ENST00000440692.6
ribosomal protein S24
chr5_+_169583636 10.23 ENST00000506574.5
ENST00000515224.5
ENST00000629457.2
ENST00000508247.5
ENST00000265295.9
ENST00000513941.5
spindle apparatus coiled-coil protein 1
chr1_+_225777813 10.15 ENST00000619790.4
ENST00000626563.2
ENST00000304786.12
ENST00000650651.1
ENST00000366839.8
ENST00000651761.1
ENST00000366838.1
signal recognition particle 9
chr10_-_119536533 10.14 ENST00000392865.5
regulator of G protein signaling 10
chr8_-_47960126 10.12 ENST00000314191.7
ENST00000338368.7
protein kinase, DNA-activated, catalytic subunit
chr17_-_782253 10.01 ENST00000628529.2
ENST00000625892.1
ENST00000301328.9
ENST00000576419.1
glyoxalase domain containing 4
chrX_-_10620534 9.98 ENST00000317552.9
midline 1
chr12_-_47705990 9.95 ENST00000432584.7
ENST00000005386.8
RNA polymerase II associated protein 3
chr11_-_111871271 9.94 ENST00000398006.6
ALG9 alpha-1,2-mannosyltransferase
chr16_+_74296789 9.94 ENST00000219313.9
ENST00000567958.5
ENST00000568615.2
proteasome 26S subunit, non-ATPase 7
chr10_-_73168052 9.92 ENST00000430082.6
ENST00000454759.6
ENST00000413026.1
ENST00000453402.5
ecdysoneless cell cycle regulator
chr20_-_2470749 9.89 ENST00000381342.7
ENST00000438552.6
small nuclear ribonucleoprotein polypeptides B and B1
chr4_+_83035159 9.84 ENST00000509317.5
ENST00000264389.7
ENST00000503682.5
ENST00000511653.1
COP9 signalosome subunit 4
chr6_+_44247087 9.69 ENST00000353801.7
ENST00000371646.10
heat shock protein 90 alpha family class B member 1
chr3_+_159839847 9.62 ENST00000445224.6
schwannomin interacting protein 1
chr4_+_168497044 9.58 ENST00000505667.6
palladin, cytoskeletal associated protein
chr3_+_62318983 9.44 ENST00000232519.9
ENST00000462069.6
ENST00000465142.5
chromosome 3 open reading frame 14
chr11_+_842928 9.41 ENST00000397408.5
tetraspanin 4
chr17_+_47209375 9.41 ENST00000572303.1
myosin light chain 4
chr20_+_49219398 9.32 ENST00000618172.5
DEAD-box helicase 27
chr5_+_31532277 9.25 ENST00000507818.6
ENST00000325366.14
chromosome 5 open reading frame 22
chr5_-_134632769 9.25 ENST00000505758.5
ENST00000439578.5
ENST00000502286.1
ENST00000402673.7
secretion associated Ras related GTPase 1B
chr12_-_56752366 9.19 ENST00000672280.1
DNA primase subunit 1
chr6_-_2841853 9.17 ENST00000380739.6
serpin family B member 1
chr15_-_101295209 9.13 ENST00000254193.11
ENST00000626000.1
small nuclear ribonucleoprotein polypeptide A'
chr4_+_17577487 9.05 ENST00000606142.5
leucine aminopeptidase 3
chr4_+_41935423 9.02 ENST00000504986.6
transmembrane protein 33
chr1_-_236604479 9.01 ENST00000366579.1
ENST00000366581.6
ENST00000366582.8
HEAT repeat containing 1
chr2_-_202911621 9.00 ENST00000261015.5
WD repeat domain 12
chr9_+_69205141 8.99 ENST00000649134.1
ENST00000539225.2
ENST00000650084.1
ENST00000648402.1
tight junction protein 2
chrX_-_109733220 8.90 ENST00000672282.1
ENST00000340800.7
acyl-CoA synthetase long chain family member 4
chr11_+_93741620 8.84 ENST00000331239.8
ENST00000533585.5
ENST00000528099.5
ENST00000530620.5
ENST00000354421.8
ENST00000527003.5
ENST00000531650.5
ENST00000530279.5
ENST00000638767.1
chromosome 11 open reading frame 54
novel protein, C11orf54-MED17 readthrough
chr6_+_10585748 8.82 ENST00000265012.5
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr6_+_135181268 8.74 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB proto-oncogene, transcription factor
chr8_+_100150621 8.70 ENST00000522439.1
ENST00000353107.8
RNA polymerase II, I and III subunit K
chrX_+_48897919 8.60 ENST00000447146.7
ENST00000247140.8
polyglutamine binding protein 1
chr6_-_127343329 8.60 ENST00000474289.6
ENST00000534442.5
ENST00000368289.6
ENST00000525745.5
ENST00000430841.6
ethylmalonyl-CoA decarboxylase 1
chr6_+_31665234 8.59 ENST00000677536.1
ENST00000375885.8
casein kinase 2 beta
chr1_+_153634037 8.50 ENST00000368694.8
ENST00000403433.5
chromatin target of PRMT1
chr5_+_72848115 8.50 ENST00000679378.1
transportin 1
chr4_+_41538143 8.49 ENST00000503057.6
ENST00000511496.5
LIM and calponin homology domains 1
chr12_+_107685759 8.36 ENST00000412830.8
ENST00000547995.5
PWP1 homolog, endonuclein
chr15_-_55249029 8.34 ENST00000566877.5
RAB27A, member RAS oncogene family
chr11_+_125626229 8.32 ENST00000532449.6
ENST00000534070.5
checkpoint kinase 1
chrX_-_109733249 8.31 ENST00000469796.7
ENST00000672401.1
ENST00000671846.1
acyl-CoA synthetase long chain family member 4
chrX_-_100636799 8.19 ENST00000373020.9
tetraspanin 6
chr4_-_139302460 8.09 ENST00000394223.2
ENST00000676245.1
NADH:ubiquinone oxidoreductase subunit C1
chr22_-_31662180 8.09 ENST00000435900.5
phosphatidylserine decarboxylase
chr8_+_109540075 8.07 ENST00000614147.1
ENST00000337573.10
estrogen receptor binding site associated antigen 9
chr8_+_109540602 8.07 ENST00000530629.5
ENST00000620557.4
estrogen receptor binding site associated antigen 9
chr2_+_73926826 8.05 ENST00000629438.2
ENST00000348222.3
ENST00000264093.9
deoxyguanosine kinase
chr4_-_139302516 7.98 ENST00000394228.5
ENST00000539387.5
NADH:ubiquinone oxidoreductase subunit C1
chr11_+_125625967 7.96 ENST00000428830.6
ENST00000278916.8
ENST00000544373.5
ENST00000532669.5
ENST00000527013.6
ENST00000526937.5
ENST00000534685.5
checkpoint kinase 1
chr17_-_31901658 7.95 ENST00000261708.9
UTP6 small subunit processome component
chr13_-_36370171 7.95 ENST00000355182.8
spartin
chr7_-_80919017 7.89 ENST00000265361.8
semaphorin 3C
chr11_-_33722941 7.85 ENST00000652678.1
CD59 molecule (CD59 blood group)
chr21_+_39387757 7.85 ENST00000380708.5
guided entry of tail-anchored proteins factor 1
chr20_-_37527723 7.77 ENST00000397135.1
ENST00000397137.5
BLCAP apoptosis inducing factor
chr15_+_48878070 7.74 ENST00000530028.3
ENST00000560490.1
EP300 interacting inhibitor of differentiation 1
chr19_-_12669388 7.62 ENST00000597961.1
ENST00000598732.1
ENST00000222190.9
ENST00000596731.7
novel protein
WD repeat domain 83 opposite strand
chr2_-_135876382 7.51 ENST00000264156.3
minichromosome maintenance complex component 6
chr17_-_15684288 7.51 ENST00000416464.6
ENST00000578237.5
ENST00000581200.1
ENST00000649191.2
tripartite motif containing 16
chr3_-_11643871 7.49 ENST00000430365.7
vestigial like family member 4
chr1_-_246566238 7.37 ENST00000366514.5
transcription factor B2, mitochondrial
chr1_-_3650063 7.35 ENST00000419924.2
ENST00000270708.12
WD repeat containing, antisense to TP73
chr10_+_13161543 7.35 ENST00000378714.8
ENST00000479669.5
ENST00000484800.6
minichromosome maintenance 10 replication initiation factor
chr20_-_37527891 7.34 ENST00000414542.6
BLCAP apoptosis inducing factor
chr19_+_984314 7.32 ENST00000587001.6
ENST00000585809.6
ENST00000251289.9
ENST00000607440.5
WD repeat domain 18
chr15_-_43824675 7.31 ENST00000267812.4
microfibril associated protein 1
chr8_-_73293616 7.23 ENST00000352983.7
ENST00000396467.5
ribosomal protein L7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 48.9 GO:0002188 translation reinitiation(GO:0002188)
7.1 21.4 GO:0006272 leading strand elongation(GO:0006272)
6.1 18.4 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
5.9 17.6 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
5.8 23.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
5.2 15.5 GO:0034729 histone H3-K79 methylation(GO:0034729)
5.1 20.2 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
5.0 25.2 GO:1902896 terminal web assembly(GO:1902896)
5.0 14.9 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
4.8 23.8 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
4.7 23.6 GO:1902093 positive regulation of sperm motility(GO:1902093)
4.7 61.0 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
4.2 12.7 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
4.2 21.0 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
4.2 12.5 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
4.2 70.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
4.1 12.3 GO:0090149 mitochondrial membrane fission(GO:0090149)
4.1 16.3 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
3.9 11.8 GO:0035720 intraciliary anterograde transport(GO:0035720)
3.9 11.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
3.8 15.1 GO:0043335 protein unfolding(GO:0043335)
3.7 11.1 GO:0051793 medium-chain fatty acid catabolic process(GO:0051793)
3.4 10.2 GO:0060382 regulation of DNA strand elongation(GO:0060382)
3.3 13.4 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
3.2 9.7 GO:1901388 regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
3.2 12.8 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
3.2 6.3 GO:1901420 negative regulation of response to alcohol(GO:1901420)
3.1 12.3 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
3.0 9.0 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
3.0 11.9 GO:0045903 positive regulation of translational fidelity(GO:0045903)
2.8 13.9 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
2.8 11.0 GO:0007113 endomitotic cell cycle(GO:0007113)
2.7 11.0 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
2.6 18.4 GO:0015866 ADP transport(GO:0015866)
2.5 12.3 GO:1901662 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
2.5 7.4 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
2.4 24.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
2.3 30.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.3 18.6 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
2.3 37.0 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
2.3 32.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
2.3 16.0 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
2.3 15.9 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
2.1 12.9 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
2.1 8.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
2.1 16.6 GO:2000210 positive regulation of anoikis(GO:2000210)
2.0 14.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
2.0 10.1 GO:0045900 negative regulation of translational elongation(GO:0045900)
2.0 12.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
2.0 19.9 GO:0045176 apical protein localization(GO:0045176)
1.9 5.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.9 20.9 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.9 55.0 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
1.8 3.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
1.7 7.0 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
1.7 10.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
1.6 21.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.6 16.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
1.6 14.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.6 22.0 GO:0035372 protein localization to microtubule(GO:0035372)
1.6 10.9 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
1.5 10.8 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
1.5 10.4 GO:1901856 negative regulation of cellular respiration(GO:1901856) regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956) negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957)
1.4 6.9 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
1.4 10.8 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.3 4.0 GO:0035425 autocrine signaling(GO:0035425)
1.3 15.9 GO:0051096 positive regulation of helicase activity(GO:0051096)
1.3 5.3 GO:0090164 protein retention in Golgi apparatus(GO:0045053) asymmetric Golgi ribbon formation(GO:0090164)
1.3 13.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
1.3 16.5 GO:0000338 protein deneddylation(GO:0000338)
1.3 8.8 GO:0036438 maintenance of lens transparency(GO:0036438)
1.3 11.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
1.2 8.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.2 8.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
1.2 3.7 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
1.2 3.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
1.2 3.5 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
1.2 7.0 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
1.1 113.0 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
1.1 4.4 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.0 12.5 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
1.0 12.3 GO:0051382 kinetochore assembly(GO:0051382)
1.0 3.9 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.9 5.5 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.9 8.0 GO:0046070 dGTP metabolic process(GO:0046070)
0.9 16.9 GO:0003334 keratinocyte development(GO:0003334)
0.9 5.3 GO:0006642 triglyceride mobilization(GO:0006642)
0.9 10.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.8 3.3 GO:0006404 RNA import into nucleus(GO:0006404)
0.8 10.8 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.8 2.5 GO:0036233 glycine import(GO:0036233)
0.8 9.0 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.8 3.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.8 5.4 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.8 9.9 GO:0040016 embryonic cleavage(GO:0040016)
0.8 7.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.7 2.2 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.7 27.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.7 5.1 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.7 21.8 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.7 10.9 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.7 1.4 GO:2000619 negative regulation of histone H4-K16 acetylation(GO:2000619)
0.7 2.1 GO:0006711 estrogen catabolic process(GO:0006711)
0.7 30.9 GO:0043029 T cell homeostasis(GO:0043029)
0.7 4.1 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.7 20.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.7 13.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.7 3.3 GO:0071964 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.7 3.3 GO:0001315 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.7 11.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.6 2.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.6 17.2 GO:0060148 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.6 2.4 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.6 4.8 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.6 17.3 GO:0031639 plasminogen activation(GO:0031639)
0.6 1.7 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.6 2.8 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.5 3.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.5 4.9 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.5 26.3 GO:0032508 DNA duplex unwinding(GO:0032508)
0.5 9.9 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.5 10.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 4.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739) calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 4.7 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.5 1.4 GO:1901804 beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.5 2.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.5 12.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.4 3.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.4 17.3 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.4 3.9 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.4 5.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.4 13.8 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.4 52.9 GO:0007062 sister chromatid cohesion(GO:0007062)
0.4 14.1 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.4 8.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 2.8 GO:0001705 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.4 4.8 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.4 39.0 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.4 5.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.4 13.5 GO:0006270 DNA replication initiation(GO:0006270)
0.4 9.9 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.4 1.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.4 21.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4 20.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.4 13.4 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.4 7.0 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.4 5.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.4 13.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.4 28.9 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.4 2.5 GO:0071569 protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.4 7.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.4 6.1 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.4 14.0 GO:0006582 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.4 22.9 GO:0006901 vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 4.2 GO:0006379 mRNA cleavage(GO:0006379)
0.3 8.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 14.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.3 6.0 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.3 1.3 GO:0033306 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.3 0.9 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.3 24.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.3 11.2 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.3 1.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 18.6 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.3 1.7 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.3 7.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.3 13.7 GO:0030224 monocyte differentiation(GO:0030224)
0.3 1.8 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.3 9.6 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.2 8.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 1.4 GO:0060356 leucine import(GO:0060356)
0.2 6.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 16.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 2.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 2.1 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237)
0.2 5.0 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.2 5.1 GO:0018126 protein hydroxylation(GO:0018126)
0.2 5.7 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.2 3.2 GO:0006020 inositol metabolic process(GO:0006020)
0.2 3.0 GO:0002323 natural killer cell activation involved in immune response(GO:0002323)
0.2 16.0 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.2 13.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 79.5 GO:0008380 RNA splicing(GO:0008380)
0.2 0.7 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.2 4.3 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.2 0.5 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.2 1.6 GO:0090656 t-circle formation(GO:0090656)
0.2 0.9 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.2 3.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 7.7 GO:0035065 regulation of histone acetylation(GO:0035065)
0.1 11.0 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 4.0 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.1 2.8 GO:0097502 mannosylation(GO:0097502)
0.1 15.0 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 3.6 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 4.4 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.1 15.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 7.3 GO:0015914 phospholipid transport(GO:0015914)
0.1 1.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.5 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 3.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 4.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 1.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 2.1 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.1 0.5 GO:0043382 positive regulation of memory T cell differentiation(GO:0043382)
0.1 3.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 1.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.5 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.1 2.0 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 13.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 6.0 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.4 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.7 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 1.8 GO:0019827 stem cell population maintenance(GO:0019827)
0.0 3.8 GO:0045444 fat cell differentiation(GO:0045444)
0.0 1.2 GO:0050918 positive chemotaxis(GO:0050918)
0.0 0.2 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.8 GO:0006968 cellular defense response(GO:0006968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
14.1 56.4 GO:1990423 RZZ complex(GO:1990423)
5.6 16.8 GO:0036284 tubulobulbar complex(GO:0036284)
5.5 61.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
5.4 27.1 GO:0033503 HULC complex(GO:0033503)
5.2 26.2 GO:0070557 PCNA-p21 complex(GO:0070557)
5.2 51.8 GO:0097255 R2TP complex(GO:0097255)
5.2 15.5 GO:0055087 Ski complex(GO:0055087)
3.8 23.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
3.8 19.0 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
3.5 21.2 GO:1990357 terminal web(GO:1990357)
3.2 48.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
3.2 9.7 GO:1990913 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
3.0 9.0 GO:0034455 t-UTP complex(GO:0034455)
2.8 36.9 GO:0005688 U6 snRNP(GO:0005688)
2.7 24.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
2.6 5.1 GO:1903349 omegasome membrane(GO:1903349)
2.5 29.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
2.4 28.4 GO:0042555 MCM complex(GO:0042555)
2.3 11.7 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.3 15.9 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
2.2 13.1 GO:0070761 pre-snoRNP complex(GO:0070761)
2.1 12.7 GO:0061617 MICOS complex(GO:0061617)
2.0 10.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
1.8 25.7 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
1.8 21.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.7 27.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
1.6 8.0 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
1.5 9.0 GO:0070545 PeBoW complex(GO:0070545)
1.4 12.8 GO:0070765 gamma-secretase complex(GO:0070765)
1.4 7.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.4 9.9 GO:0005683 U7 snRNP(GO:0005683)
1.3 1.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
1.3 3.9 GO:0044393 microspike(GO:0044393)
1.3 10.2 GO:0070187 telosome(GO:0070187)
1.2 8.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
1.2 33.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.2 22.0 GO:0005641 nuclear envelope lumen(GO:0005641)
1.1 10.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
1.1 23.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
1.0 15.3 GO:0000346 transcription export complex(GO:0000346)
1.0 4.0 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
1.0 20.9 GO:0097342 ripoptosome(GO:0097342)
1.0 11.8 GO:0044292 dendrite terminus(GO:0044292)
1.0 58.5 GO:0005871 kinesin complex(GO:0005871)
1.0 8.6 GO:0001739 sex chromatin(GO:0001739)
1.0 12.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.0 5.7 GO:0005816 spindle pole body(GO:0005816)
0.9 12.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.9 6.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.9 28.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.9 21.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.9 60.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 7.4 GO:0031298 replication fork protection complex(GO:0031298)
0.8 3.3 GO:0071920 cleavage body(GO:0071920)
0.8 6.5 GO:0051286 cell tip(GO:0051286)
0.7 5.5 GO:0061689 tricellular tight junction(GO:0061689)
0.7 13.9 GO:0031932 TORC2 complex(GO:0031932)
0.7 4.6 GO:0016589 NURF complex(GO:0016589)
0.6 11.0 GO:0032433 filopodium tip(GO:0032433)
0.6 2.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.6 5.0 GO:0034709 methylosome(GO:0034709)
0.6 9.1 GO:0005686 U2 snRNP(GO:0005686)
0.6 1.7 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.6 15.8 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.5 7.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.5 4.4 GO:0030891 VCB complex(GO:0030891)
0.5 8.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.5 27.9 GO:0002102 podosome(GO:0002102)
0.5 2.4 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.5 3.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 12.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.5 21.1 GO:0005844 polysome(GO:0005844)
0.5 5.0 GO:0000124 SAGA complex(GO:0000124)
0.4 5.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.4 23.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 7.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.4 10.7 GO:0097228 sperm principal piece(GO:0097228)
0.4 23.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.3 16.5 GO:0008180 COP9 signalosome(GO:0008180)
0.3 24.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 2.9 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.3 1.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.3 0.9 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.3 39.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 17.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 19.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.2 24.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 35.0 GO:0000781 chromosome, telomeric region(GO:0000781)
0.2 0.6 GO:0032302 MutSbeta complex(GO:0032302)
0.2 20.3 GO:0016459 myosin complex(GO:0016459)
0.2 4.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 7.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 2.0 GO:0044666 MLL3/4 complex(GO:0044666) Set1C/COMPASS complex(GO:0048188)
0.2 4.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 2.1 GO:0030008 TRAPP complex(GO:0030008)
0.2 1.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 24.9 GO:0030496 midbody(GO:0030496)
0.2 0.5 GO:0002079 inner acrosomal membrane(GO:0002079)
0.2 0.9 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.2 7.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 15.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 5.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 6.2 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.5 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 1.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 45.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 4.5 GO:0090544 BAF-type complex(GO:0090544)
0.1 11.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 35.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 11.7 GO:0043202 lysosomal lumen(GO:0043202)
0.1 6.5 GO:0031970 organelle envelope lumen(GO:0031970)
0.1 15.9 GO:0034399 nuclear periphery(GO:0034399)
0.1 8.6 GO:0016605 PML body(GO:0016605)
0.1 4.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 4.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 3.3 GO:0005643 nuclear pore(GO:0005643)
0.0 3.4 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 35.4 GO:0005730 nucleolus(GO:0005730)
0.0 19.1 GO:0005925 focal adhesion(GO:0005925)
0.0 5.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 8.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 5.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.1 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 30.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
7.8 23.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
7.7 23.0 GO:0003896 DNA primase activity(GO:0003896)
7.1 21.4 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
6.1 24.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
6.0 18.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
5.9 17.7 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
5.9 17.6 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
4.7 23.6 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
4.7 14.0 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
4.2 12.7 GO:0010698 acetyltransferase activator activity(GO:0010698)
4.1 12.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
4.1 41.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
4.1 16.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
4.0 15.9 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
3.7 11.1 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
3.7 11.0 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
3.6 14.4 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
3.4 10.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
3.3 13.4 GO:0002060 purine nucleobase binding(GO:0002060)
3.3 16.6 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
3.2 12.9 GO:0042134 rRNA primary transcript binding(GO:0042134)
3.0 23.8 GO:0032552 deoxyribonucleotide binding(GO:0032552)
2.8 11.3 GO:0043515 kinetochore binding(GO:0043515)
2.8 13.8 GO:0004771 sterol esterase activity(GO:0004771)
2.7 10.8 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
2.6 37.0 GO:0046790 virion binding(GO:0046790)
2.6 18.4 GO:0015217 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
2.5 20.3 GO:0019237 centromeric DNA binding(GO:0019237)
2.5 20.1 GO:0030620 U2 snRNA binding(GO:0030620)
2.5 7.5 GO:0032089 NACHT domain binding(GO:0032089)
2.5 9.9 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
2.3 11.7 GO:0000104 succinate dehydrogenase activity(GO:0000104)
2.3 6.9 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
2.0 10.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
2.0 8.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.9 15.1 GO:0030911 TPR domain binding(GO:0030911)
1.7 10.1 GO:0005047 signal recognition particle binding(GO:0005047)
1.7 47.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.6 9.6 GO:0032038 myosin II heavy chain binding(GO:0032038)
1.6 29.5 GO:0017070 U6 snRNA binding(GO:0017070)
1.5 13.1 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
1.4 55.0 GO:0005540 hyaluronic acid binding(GO:0005540)
1.4 19.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
1.3 8.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
1.2 4.9 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971) thiol oxidase activity(GO:0016972)
1.2 7.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
1.2 36.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
1.1 4.6 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
1.1 12.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.1 9.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
1.1 9.8 GO:0019784 NEDD8-specific protease activity(GO:0019784)
1.1 53.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.0 26.3 GO:0032794 GTPase activating protein binding(GO:0032794)
1.0 4.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.0 20.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.9 25.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.9 8.3 GO:0004645 phosphorylase activity(GO:0004645)
0.9 27.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.9 19.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.8 6.6 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.8 4.8 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.8 16.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.8 2.3 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.7 20.8 GO:0001848 complement binding(GO:0001848)
0.7 3.5 GO:0019776 Atg8 ligase activity(GO:0019776)
0.7 48.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 2.8 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.7 8.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 3.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.6 8.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.6 2.4 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.6 4.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.6 11.7 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.6 1.7 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.6 24.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.6 17.0 GO:0030515 snoRNA binding(GO:0030515)
0.6 5.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.5 30.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.5 8.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.5 16.1 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.5 13.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.5 13.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.5 13.7 GO:0031489 myosin V binding(GO:0031489)
0.5 39.4 GO:0003777 microtubule motor activity(GO:0003777)
0.5 30.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.5 7.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 2.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.5 6.0 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.5 1.4 GO:0015616 DNA translocase activity(GO:0015616)
0.5 7.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 10.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 13.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4 5.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4 1.6 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.4 21.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 13.7 GO:0001671 ATPase activator activity(GO:0001671)
0.4 2.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 12.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 11.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 2.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.4 1.4 GO:0004348 glucosylceramidase activity(GO:0004348)
0.3 5.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.3 3.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 16.0 GO:0042169 SH2 domain binding(GO:0042169)
0.3 12.4 GO:0043022 ribosome binding(GO:0043022)
0.3 7.0 GO:0002162 dystroglycan binding(GO:0002162)
0.3 1.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.3 62.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 7.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 7.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 10.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 3.6 GO:0046870 cadmium ion binding(GO:0046870)
0.3 8.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 4.4 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.3 1.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.3 5.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 14.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 6.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 3.3 GO:0000339 RNA cap binding(GO:0000339)
0.2 12.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 0.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2 6.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 0.6 GO:0000406 double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.2 11.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 1.4 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.2 6.7 GO:0003785 actin monomer binding(GO:0003785)
0.2 5.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 3.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.2 2.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 9.0 GO:0030145 manganese ion binding(GO:0030145)
0.2 15.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.9 GO:0089720 caspase binding(GO:0089720)
0.2 9.9 GO:0042379 chemokine receptor binding(GO:0042379)
0.2 3.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 2.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 22.9 GO:0043130 ubiquitin binding(GO:0043130)
0.2 3.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 10.4 GO:0051018 protein kinase A binding(GO:0051018)
0.2 5.9 GO:0001972 retinoic acid binding(GO:0001972)
0.2 3.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 18.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 3.2 GO:0005123 death receptor binding(GO:0005123)
0.2 29.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 4.0 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 3.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 11.3 GO:0051087 chaperone binding(GO:0051087)
0.1 3.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 11.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 2.0 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 1.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 18.3 GO:0005125 cytokine activity(GO:0005125)
0.1 4.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 3.7 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 11.4 GO:0016597 amino acid binding(GO:0016597)
0.1 4.6 GO:0031491 nucleosome binding(GO:0031491)
0.1 7.1 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.1 4.5 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.1 0.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 6.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.4 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 1.2 GO:0042056 chemoattractant activity(GO:0042056)
0.1 4.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 16.5 GO:0045296 cadherin binding(GO:0045296)
0.0 3.3 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 6.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 4.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 2.7 GO:0016829 lyase activity(GO:0016829)
0.0 3.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.5 GO:0016887 ATPase activity(GO:0016887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 61.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.5 21.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.4 84.4 PID AURORA B PATHWAY Aurora B signaling
0.8 8.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.8 24.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.7 43.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.7 18.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.6 18.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.6 18.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.6 20.2 PID BARD1 PATHWAY BARD1 signaling events
0.5 39.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 26.1 PID ATR PATHWAY ATR signaling pathway
0.4 10.1 PID IL3 PATHWAY IL3-mediated signaling events
0.4 13.9 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.4 31.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.4 15.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.4 13.1 PID MYC PATHWAY C-MYC pathway
0.4 12.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.4 12.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 16.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 10.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 10.4 PID RHOA PATHWAY RhoA signaling pathway
0.2 17.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 4.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 10.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 27.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 4.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 8.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 11.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 11.9 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 9.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 4.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 3.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.3 PID FOXO PATHWAY FoxO family signaling
0.1 9.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 10.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.9 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 44.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
2.7 38.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
2.5 61.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
2.0 30.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
2.0 56.0 REACTOME KINESINS Genes involved in Kinesins
1.9 13.1 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.8 3.6 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
1.5 113.0 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
1.4 54.5 REACTOME G2 M CHECKPOINTS Genes involved in G2/M Checkpoints
1.3 10.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
1.2 19.9 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
1.2 29.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
1.1 45.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.9 18.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.9 21.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.8 3.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.8 24.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.7 21.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.7 10.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.7 9.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.7 20.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.7 11.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 18.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 22.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.6 17.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.6 5.7 REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.6 10.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.5 15.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.5 57.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 43.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.5 12.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 7.5 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.4 5.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.4 13.0 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.4 8.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.4 9.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 8.5 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.4 11.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.4 17.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 13.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 4.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 5.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 37.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.3 10.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.3 21.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 35.0 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 8.1 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.2 5.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 4.7 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 10.4 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 8.6 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.2 7.9 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 4.0 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.2 14.0 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.2 3.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 4.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 11.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 7.4 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.2 31.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 7.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 5.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 17.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 1.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 3.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 3.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 4.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT