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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SPI1
Z-value: 6.20
Motif logo
Transcription factors associated with SPI1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SPI1
|
ENSG00000066336.12 | SPI1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPI1 | hg38_v1_chr11_-_47378391_47378410, hg38_v1_chr11_-_47378527_47378555 | 0.48 | 4.7e-14 | Click! |
Activity profile of SPI1 motif
Sorted Z-values of SPI1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of SPI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 43.6 | 130.7 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 28.0 | 84.0 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 23.5 | 93.8 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 22.8 | 68.4 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 18.1 | 145.2 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 16.3 | 49.0 | GO:1903595 | positive regulation of histamine secretion by mast cell(GO:1903595) |
| 16.3 | 48.9 | GO:1904845 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 15.7 | 62.6 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 15.4 | 77.1 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 15.4 | 46.2 | GO:0060369 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) mast cell proliferation(GO:0070662) |
| 14.9 | 44.6 | GO:0002188 | translation reinitiation(GO:0002188) |
| 14.2 | 42.6 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 13.8 | 96.8 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 13.4 | 40.1 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 12.5 | 50.1 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 12.0 | 48.1 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 11.8 | 47.2 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 11.7 | 35.2 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 11.7 | 11.7 | GO:1903006 | regulation of protein K63-linked deubiquitination(GO:1903004) positive regulation of protein K63-linked deubiquitination(GO:1903006) |
| 11.6 | 34.9 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 11.6 | 34.7 | GO:0060623 | regulation of chromosome condensation(GO:0060623) |
| 11.4 | 45.4 | GO:0002357 | defense response to tumor cell(GO:0002357) |
| 10.9 | 54.7 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 10.9 | 65.6 | GO:0006226 | dUMP biosynthetic process(GO:0006226) |
| 10.8 | 43.3 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 10.5 | 10.5 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 10.0 | 50.1 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 9.1 | 36.3 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
| 9.1 | 36.2 | GO:0052053 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 9.0 | 26.9 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 8.5 | 127.8 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 8.5 | 93.6 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 8.5 | 25.5 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 8.5 | 42.3 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 8.3 | 41.5 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 7.9 | 55.5 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 7.4 | 14.8 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 7.4 | 29.5 | GO:0045401 | positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) |
| 7.2 | 21.7 | GO:0002349 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
| 7.2 | 29.0 | GO:0010796 | regulation of multivesicular body size(GO:0010796) |
| 6.9 | 27.7 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 6.8 | 20.5 | GO:0045588 | positive regulation of gamma-delta T cell differentiation(GO:0045588) |
| 6.8 | 20.5 | GO:0098905 | regulation of bundle of His cell action potential(GO:0098905) |
| 6.8 | 13.5 | GO:0035743 | CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745) |
| 6.7 | 53.6 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 6.5 | 103.3 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 6.2 | 31.0 | GO:0070425 | negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) |
| 6.2 | 117.4 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 6.2 | 80.2 | GO:0045651 | positive regulation of macrophage differentiation(GO:0045651) |
| 6.1 | 18.3 | GO:2000538 | regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 5.9 | 17.8 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 5.8 | 17.5 | GO:0060957 | endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445) |
| 5.7 | 23.0 | GO:0050916 | sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917) |
| 5.7 | 131.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 5.7 | 68.4 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 5.5 | 33.1 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 5.5 | 16.5 | GO:0090149 | synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149) |
| 5.4 | 16.1 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 5.3 | 42.3 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 5.2 | 73.0 | GO:0051014 | actin filament severing(GO:0051014) |
| 5.2 | 51.7 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 5.2 | 10.3 | GO:0071677 | positive regulation of mononuclear cell migration(GO:0071677) |
| 4.9 | 34.3 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
| 4.9 | 24.3 | GO:0034127 | detection of lipopolysaccharide(GO:0032497) regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034127) negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
| 4.8 | 48.1 | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) |
| 4.8 | 14.4 | GO:1903719 | regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) |
| 4.7 | 14.1 | GO:1903674 | regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676) |
| 4.6 | 13.9 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 4.6 | 9.3 | GO:0001810 | regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068) |
| 4.6 | 77.9 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 4.6 | 86.6 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 4.5 | 27.2 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 4.5 | 18.1 | GO:0002913 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 4.5 | 13.5 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 4.5 | 17.8 | GO:0090135 | actin filament branching(GO:0090135) protein localization to cell leading edge(GO:1902463) |
| 4.4 | 17.5 | GO:0021569 | rhombomere 3 development(GO:0021569) |
| 4.3 | 13.0 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 4.3 | 21.7 | GO:0030242 | pexophagy(GO:0030242) |
| 4.3 | 30.0 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 4.2 | 38.1 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 4.2 | 16.8 | GO:0016334 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 4.2 | 8.3 | GO:0009826 | unidimensional cell growth(GO:0009826) |
| 4.1 | 49.3 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 4.0 | 24.0 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 4.0 | 15.8 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 3.9 | 133.6 | GO:0045730 | respiratory burst(GO:0045730) |
| 3.9 | 74.5 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 3.9 | 27.4 | GO:0002353 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 3.8 | 53.6 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 3.8 | 82.8 | GO:0097320 | membrane tubulation(GO:0097320) |
| 3.7 | 26.2 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 3.7 | 14.8 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 3.7 | 11.0 | GO:2000395 | ubiquitin-dependent endocytosis(GO:0070086) positive regulation of viral budding via host ESCRT complex(GO:1903774) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 3.6 | 7.2 | GO:0001923 | B-1 B cell differentiation(GO:0001923) |
| 3.6 | 35.8 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 3.6 | 17.8 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 3.5 | 14.2 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 3.5 | 35.2 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 3.5 | 42.0 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 3.5 | 125.1 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 3.5 | 17.3 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) |
| 3.4 | 20.6 | GO:0042997 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 3.4 | 30.7 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 3.3 | 16.6 | GO:1900127 | positive regulation of hyaluronan biosynthetic process(GO:1900127) |
| 3.3 | 55.7 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 3.3 | 22.8 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 3.2 | 6.5 | GO:0002339 | B cell selection(GO:0002339) |
| 3.2 | 35.6 | GO:0007144 | female meiosis I(GO:0007144) |
| 3.2 | 28.7 | GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway(GO:0034141) |
| 3.2 | 25.5 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 3.2 | 28.6 | GO:0006167 | AMP biosynthetic process(GO:0006167) |
| 3.2 | 9.5 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 3.2 | 31.5 | GO:0006116 | NADH oxidation(GO:0006116) |
| 3.1 | 24.7 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 3.1 | 21.5 | GO:0008215 | spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295) |
| 3.0 | 5.9 | GO:0072679 | thymocyte migration(GO:0072679) |
| 2.9 | 14.7 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 2.9 | 14.6 | GO:0043307 | eosinophil activation(GO:0043307) |
| 2.9 | 37.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 2.9 | 5.8 | GO:0033029 | regulation of neutrophil apoptotic process(GO:0033029) |
| 2.9 | 48.7 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 2.9 | 34.3 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 2.8 | 28.3 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 2.7 | 10.8 | GO:0002384 | hepatic immune response(GO:0002384) |
| 2.7 | 40.5 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 2.6 | 7.9 | GO:0090234 | regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234) |
| 2.6 | 23.5 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 2.6 | 20.5 | GO:0035771 | interleukin-4-mediated signaling pathway(GO:0035771) |
| 2.6 | 7.7 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 2.5 | 57.9 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 2.5 | 7.5 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 2.5 | 2.5 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) |
| 2.5 | 17.3 | GO:1902961 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 2.5 | 22.2 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 2.4 | 9.7 | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
| 2.4 | 7.2 | GO:2000681 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 2.4 | 23.7 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 2.3 | 6.8 | GO:0070370 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 2.2 | 6.7 | GO:2000234 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 2.2 | 4.4 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 2.2 | 21.9 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 2.2 | 30.4 | GO:0002281 | macrophage activation involved in immune response(GO:0002281) |
| 2.1 | 42.0 | GO:0097341 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 2.1 | 16.7 | GO:0007068 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 2.1 | 4.1 | GO:0032930 | positive regulation of superoxide anion generation(GO:0032930) |
| 2.1 | 69.9 | GO:1903393 | positive regulation of focal adhesion assembly(GO:0051894) positive regulation of adherens junction organization(GO:1903393) |
| 2.0 | 53.1 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 2.0 | 11.8 | GO:1990592 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 1.9 | 25.1 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 1.9 | 17.3 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 1.9 | 30.6 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 1.9 | 11.4 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 1.9 | 5.7 | GO:0033385 | geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386) |
| 1.9 | 26.5 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 1.9 | 13.2 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 1.9 | 37.6 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 1.9 | 31.7 | GO:0002347 | response to tumor cell(GO:0002347) |
| 1.8 | 14.7 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
| 1.8 | 3.7 | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 1.8 | 49.2 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 1.8 | 14.4 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 1.8 | 28.4 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 1.8 | 47.8 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 1.7 | 19.1 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 1.7 | 5.2 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 1.7 | 10.3 | GO:0043316 | cytotoxic T cell degranulation(GO:0043316) positive regulation of constitutive secretory pathway(GO:1903435) |
| 1.7 | 51.2 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 1.7 | 62.1 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway(GO:0035666) |
| 1.7 | 268.9 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 1.7 | 21.5 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 1.6 | 6.6 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 1.6 | 24.2 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 1.6 | 165.0 | GO:1902036 | regulation of hematopoietic stem cell differentiation(GO:1902036) |
| 1.6 | 15.8 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 1.5 | 44.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 1.5 | 10.8 | GO:2001140 | regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140) |
| 1.5 | 23.1 | GO:0034447 | very-low-density lipoprotein particle clearance(GO:0034447) |
| 1.5 | 15.4 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 1.5 | 15.1 | GO:0000012 | single strand break repair(GO:0000012) |
| 1.5 | 7.5 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 1.5 | 10.5 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 1.5 | 22.4 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.5 | 13.2 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 1.5 | 5.8 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 1.5 | 10.2 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 1.4 | 18.6 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 1.4 | 23.8 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
| 1.4 | 7.0 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 1.4 | 44.2 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 1.4 | 28.7 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 1.4 | 17.7 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 1.4 | 52.9 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 1.3 | 13.4 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 1.3 | 38.1 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 1.3 | 23.4 | GO:1900363 | regulation of mRNA polyadenylation(GO:1900363) |
| 1.3 | 29.9 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 1.3 | 7.8 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 1.3 | 18.0 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 1.3 | 3.8 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 1.3 | 69.6 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) negative regulation of leukocyte proliferation(GO:0070664) |
| 1.2 | 6.2 | GO:0060613 | fat pad development(GO:0060613) |
| 1.2 | 4.9 | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201) |
| 1.2 | 15.8 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 1.2 | 19.1 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 1.2 | 13.1 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 1.2 | 7.0 | GO:0051665 | membrane raft localization(GO:0051665) |
| 1.2 | 84.2 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.1 | 5.7 | GO:0042376 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 1.1 | 4.6 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) negative regulation of histone H3-K4 methylation(GO:0051572) |
| 1.1 | 4.5 | GO:0045048 | protein insertion into ER membrane(GO:0045048) |
| 1.1 | 8.9 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 1.1 | 7.8 | GO:0001712 | ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712) |
| 1.1 | 11.0 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
| 1.1 | 24.1 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 1.1 | 143.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.1 | 34.7 | GO:0050869 | negative regulation of B cell activation(GO:0050869) |
| 1.1 | 41.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 1.1 | 9.6 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
| 1.0 | 39.2 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 1.0 | 33.8 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 1.0 | 4.1 | GO:0032903 | viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 1.0 | 3.0 | GO:1904457 | glucosylceramide catabolic process(GO:0006680) beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457) |
| 1.0 | 6.0 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 1.0 | 12.9 | GO:0060004 | reflex(GO:0060004) |
| 1.0 | 2.9 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 1.0 | 4.9 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 0.9 | 25.1 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.9 | 2.8 | GO:0001927 | exocyst assembly(GO:0001927) |
| 0.9 | 6.4 | GO:0015677 | copper ion import(GO:0015677) |
| 0.9 | 7.3 | GO:0034625 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.9 | 8.2 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.9 | 10.4 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.9 | 2.6 | GO:0086092 | regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium:sodium antiporter activity(GO:1903279) positive regulation of calcium:sodium antiporter activity(GO:1903281) |
| 0.8 | 11.0 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.8 | 10.1 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.8 | 3.3 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.8 | 18.7 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.8 | 6.4 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.8 | 4.6 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.7 | 6.0 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.7 | 58.9 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.7 | 15.5 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.7 | 4.9 | GO:0002517 | T cell tolerance induction(GO:0002517) |
| 0.7 | 43.4 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.7 | 26.8 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.7 | 4.1 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.7 | 7.3 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.7 | 45.6 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 0.6 | 7.7 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.6 | 24.6 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.6 | 3.7 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.6 | 11.5 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.6 | 22.4 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.6 | 3.5 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.6 | 10.3 | GO:0039694 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.6 | 12.6 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.6 | 4.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.6 | 2.3 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504) |
| 0.6 | 7.3 | GO:0032753 | positive regulation of interleukin-4 production(GO:0032753) |
| 0.5 | 10.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.5 | 12.2 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.5 | 1.6 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.5 | 3.1 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.5 | 3.6 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.5 | 6.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.5 | 4.2 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.5 | 38.3 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.5 | 5.6 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.5 | 17.9 | GO:0046039 | GTP metabolic process(GO:0046039) |
| 0.5 | 10.9 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.5 | 1.9 | GO:0034091 | regulation of maintenance of sister chromatid cohesion(GO:0034091) regulation of maintenance of mitotic sister chromatid cohesion(GO:0034182) |
| 0.5 | 1.9 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.5 | 19.5 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.4 | 15.7 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
| 0.4 | 15.1 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.4 | 23.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.4 | 75.1 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.4 | 2.2 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.4 | 33.3 | GO:0048208 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.4 | 8.6 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.4 | 57.1 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.4 | 1.3 | GO:0031550 | positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550) |
| 0.4 | 10.9 | GO:0010259 | multicellular organism aging(GO:0010259) |
| 0.4 | 18.9 | GO:0061001 | regulation of dendritic spine morphogenesis(GO:0061001) |
| 0.4 | 1.6 | GO:0046532 | regulation of photoreceptor cell differentiation(GO:0046532) |
| 0.4 | 11.5 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.4 | 2.0 | GO:0001783 | B cell apoptotic process(GO:0001783) |
| 0.4 | 3.6 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.4 | 69.1 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.4 | 17.4 | GO:0002220 | innate immune response activating cell surface receptor signaling pathway(GO:0002220) stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.4 | 2.2 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.4 | 19.2 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.4 | 29.7 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.4 | 21.6 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.4 | 3.6 | GO:0036507 | protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.3 | 2.8 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) positive regulation of cardiac muscle contraction(GO:0060452) |
| 0.3 | 25.6 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.3 | 1.0 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.3 | 9.8 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.3 | 8.1 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.3 | 2.4 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.3 | 6.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.3 | 21.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.3 | 2.3 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.3 | 4.6 | GO:0046850 | regulation of bone remodeling(GO:0046850) |
| 0.3 | 2.5 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.3 | 5.4 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.3 | 8.6 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.3 | 1.1 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.2 | 6.0 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.2 | 13.8 | GO:0042113 | B cell activation(GO:0042113) |
| 0.2 | 9.4 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.2 | 16.6 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.2 | 3.6 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 18.6 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.2 | 29.7 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.2 | 10.1 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.2 | 1.9 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.2 | 1.5 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.2 | 3.7 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.2 | 4.8 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.2 | 14.6 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.2 | 1.4 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.2 | 2.8 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.2 | 1.7 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.1 | 2.0 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.1 | 2.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 1.1 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.1 | 0.8 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) netrin-activated signaling pathway(GO:0038007) |
| 0.1 | 1.1 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.1 | 3.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 2.7 | GO:0017004 | cytochrome complex assembly(GO:0017004) |
| 0.1 | 3.5 | GO:0000305 | response to oxygen radical(GO:0000305) |
| 0.1 | 0.2 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) |
| 0.1 | 9.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 2.3 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.1 | 1.6 | GO:0031034 | myosin filament assembly(GO:0031034) |
| 0.1 | 1.3 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 1.1 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.1 | 1.4 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.1 | 5.3 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.1 | 1.4 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.1 | 5.5 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 0.1 | 0.5 | GO:0000154 | rRNA modification(GO:0000154) |
| 0.1 | 0.3 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.1 | 0.5 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.1 | 0.5 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.1 | 1.1 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.1 | 27.1 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.1 | 2.7 | GO:0048477 | oogenesis(GO:0048477) |
| 0.1 | 2.5 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 0.1 | GO:0010454 | negative regulation of cell fate commitment(GO:0010454) |
| 0.0 | 0.2 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.0 | 1.1 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.9 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 2.6 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity(GO:2000117) |
| 0.0 | 0.8 | GO:0072673 | lamellipodium morphogenesis(GO:0072673) |
| 0.0 | 0.1 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 2.7 | GO:0009267 | cellular response to starvation(GO:0009267) |
| 0.0 | 0.5 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 1.0 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.0 | 0.8 | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway(GO:0060071) regulation of establishment of planar polarity(GO:0090175) |
| 0.0 | 2.2 | GO:0006457 | protein folding(GO:0006457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 28.1 | 84.2 | GO:0008623 | CHRAC(GO:0008623) |
| 27.6 | 82.8 | GO:0036284 | tubulobulbar complex(GO:0036284) |
| 18.2 | 164.1 | GO:0032010 | phagolysosome(GO:0032010) |
| 17.7 | 124.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 17.3 | 103.9 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 15.6 | 171.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 13.9 | 55.5 | GO:0071817 | MMXD complex(GO:0071817) |
| 12.0 | 84.0 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 11.6 | 57.9 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 9.6 | 57.5 | GO:0097422 | tubular endosome(GO:0097422) |
| 9.6 | 47.9 | GO:0036398 | TCR signalosome(GO:0036398) |
| 9.2 | 46.2 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 9.1 | 36.3 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 7.7 | 192.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 7.3 | 94.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 6.7 | 26.9 | GO:0071159 | NF-kappaB complex(GO:0071159) |
| 6.7 | 26.7 | GO:0005715 | late recombination nodule(GO:0005715) |
| 6.5 | 51.7 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 6.2 | 31.2 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 6.2 | 31.0 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 6.2 | 24.6 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 6.0 | 29.9 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 5.9 | 71.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 5.8 | 17.4 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 5.3 | 48.0 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 5.0 | 45.4 | GO:0044194 | cytolytic granule(GO:0044194) |
| 4.9 | 73.0 | GO:0032059 | bleb(GO:0032059) |
| 4.5 | 40.5 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 4.4 | 17.5 | GO:0048179 | activin receptor complex(GO:0048179) |
| 4.3 | 38.8 | GO:0097452 | GAIT complex(GO:0097452) |
| 4.1 | 20.4 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 4.0 | 40.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 3.9 | 27.2 | GO:0034719 | SMN-Sm protein complex(GO:0034719) |
| 3.5 | 31.9 | GO:0042382 | paraspeckles(GO:0042382) |
| 3.5 | 34.7 | GO:0008278 | cohesin complex(GO:0008278) |
| 3.5 | 17.3 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 3.4 | 13.6 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 3.4 | 57.7 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 3.4 | 16.8 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 3.3 | 85.2 | GO:0005685 | U1 snRNP(GO:0005685) |
| 3.2 | 205.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 3.0 | 21.1 | GO:0032021 | NELF complex(GO:0032021) |
| 3.0 | 24.1 | GO:0072487 | MSL complex(GO:0072487) |
| 2.9 | 23.5 | GO:0070522 | nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522) |
| 2.9 | 17.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 2.8 | 19.7 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 2.5 | 44.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 2.4 | 14.6 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 2.3 | 16.4 | GO:0016272 | prefoldin complex(GO:0016272) |
| 2.3 | 177.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 2.3 | 58.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 2.2 | 26.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 2.2 | 10.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 2.1 | 14.7 | GO:1990037 | Lewy body core(GO:1990037) |
| 2.1 | 12.5 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 2.0 | 15.7 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 2.0 | 23.4 | GO:0030008 | TRAPP complex(GO:0030008) |
| 1.9 | 11.7 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 1.9 | 19.3 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 1.9 | 20.8 | GO:0032039 | integrator complex(GO:0032039) |
| 1.9 | 13.0 | GO:0031429 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 1.8 | 7.2 | GO:0032449 | CBM complex(GO:0032449) |
| 1.8 | 66.4 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 1.8 | 26.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 1.8 | 72.0 | GO:0002102 | podosome(GO:0002102) |
| 1.7 | 36.2 | GO:0097342 | ripoptosome(GO:0097342) |
| 1.7 | 37.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 1.7 | 16.6 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 1.6 | 6.6 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 1.6 | 30.4 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 1.6 | 15.6 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 1.5 | 21.3 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 1.5 | 17.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 1.5 | 116.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 1.5 | 7.3 | GO:0032044 | DSIF complex(GO:0032044) |
| 1.4 | 18.8 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 1.4 | 31.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 1.4 | 146.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.4 | 23.6 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 1.3 | 14.8 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 1.3 | 24.7 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 1.3 | 6.4 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 1.3 | 8.9 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 1.3 | 10.2 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500) |
| 1.3 | 89.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 1.2 | 8.6 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 1.2 | 11.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 1.1 | 7.8 | GO:0044614 | nuclear pore cytoplasmic filaments(GO:0044614) |
| 1.1 | 5.5 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 1.1 | 13.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 1.1 | 110.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 1.0 | 10.2 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 1.0 | 10.1 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 1.0 | 4.9 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 1.0 | 5.8 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 1.0 | 14.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.9 | 32.1 | GO:0071564 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.9 | 80.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.9 | 66.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.9 | 23.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.8 | 18.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.8 | 14.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.8 | 2.5 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.8 | 32.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.8 | 13.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.8 | 88.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.8 | 7.7 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.8 | 116.5 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.7 | 2.2 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.7 | 61.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.7 | 65.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.7 | 38.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.7 | 14.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.7 | 85.8 | GO:0005903 | brush border(GO:0005903) |
| 0.7 | 253.7 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.7 | 8.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.7 | 81.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.6 | 6.2 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 0.6 | 30.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.6 | 2.9 | GO:0030532 | small nuclear ribonucleoprotein complex(GO:0030532) |
| 0.6 | 2.8 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.5 | 6.0 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.5 | 6.5 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.5 | 73.4 | GO:0016605 | PML body(GO:0016605) |
| 0.5 | 21.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.5 | 3.6 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.5 | 29.9 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.5 | 22.9 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.5 | 4.1 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.4 | 163.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 2.6 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.4 | 1.3 | GO:0055087 | Ski complex(GO:0055087) |
| 0.4 | 36.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.4 | 1.2 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.4 | 1.6 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.4 | 7.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.4 | 1.2 | GO:0032009 | early phagosome(GO:0032009) |
| 0.4 | 1.5 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.4 | 2.9 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.4 | 60.0 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.3 | 10.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.3 | 1.3 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.3 | 8.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.3 | 36.9 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.3 | 1.5 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.3 | 2.9 | GO:0097433 | dense body(GO:0097433) |
| 0.3 | 10.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.3 | 7.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.3 | 3.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 3.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.3 | 0.8 | GO:1990393 | 3M complex(GO:1990393) |
| 0.3 | 5.5 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.3 | 4.6 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.3 | 1.3 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.3 | 3.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.3 | 32.3 | GO:0000922 | spindle pole(GO:0000922) |
| 0.2 | 71.8 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 0.2 | 2.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.2 | 36.7 | GO:0005819 | spindle(GO:0005819) |
| 0.2 | 19.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 1.9 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.2 | 48.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 4.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 0.8 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.2 | 1.7 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.2 | 2.8 | GO:0000145 | exocyst(GO:0000145) |
| 0.2 | 19.4 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.2 | 3.9 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 27.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 11.3 | GO:0031970 | organelle envelope lumen(GO:0031970) |
| 0.1 | 2.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 36.1 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.1 | 1.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 3.8 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.1 | 4.6 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 2.1 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.1 | 4.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 24.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 0.9 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 201.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 1.6 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 1.0 | GO:0036452 | ESCRT complex(GO:0036452) |
| 0.1 | 1.7 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 2.8 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 39.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 2.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 4.1 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 1.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 7.4 | GO:0005635 | nuclear envelope(GO:0005635) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.5 | 93.8 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 21.9 | 65.6 | GO:0004132 | dCMP deaminase activity(GO:0004132) |
| 20.5 | 164.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 18.4 | 73.6 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 14.8 | 103.9 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 13.4 | 40.1 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 11.8 | 47.2 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 11.6 | 57.9 | GO:0003920 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 10.9 | 43.8 | GO:0015207 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 9.7 | 48.7 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 9.7 | 29.0 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 9.5 | 47.3 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 8.5 | 68.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 8.5 | 68.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 8.4 | 167.1 | GO:0005522 | profilin binding(GO:0005522) |
| 7.7 | 92.7 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 7.6 | 38.1 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 7.2 | 130.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 7.0 | 77.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 6.5 | 51.7 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 6.2 | 18.6 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 6.2 | 49.3 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 6.1 | 18.3 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 6.0 | 36.2 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 5.7 | 23.0 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 5.4 | 174.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 5.4 | 64.5 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 5.2 | 15.6 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 5.0 | 15.1 | GO:0033699 | DNA 5'-adenosine monophosphate hydrolase activity(GO:0033699) |
| 4.7 | 23.4 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 4.5 | 27.2 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 4.4 | 124.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 4.4 | 13.2 | GO:0050146 | nucleoside phosphotransferase activity(GO:0050146) |
| 4.4 | 48.1 | GO:0004673 | protein histidine kinase activity(GO:0004673) |
| 4.3 | 25.8 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 4.2 | 42.0 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 4.0 | 15.8 | GO:0019976 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 3.9 | 19.6 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 3.8 | 65.3 | GO:0019864 | IgG binding(GO:0019864) |
| 3.8 | 26.8 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 3.7 | 14.6 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 3.7 | 7.3 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 3.6 | 10.8 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 3.6 | 10.8 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 3.6 | 96.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 3.5 | 14.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 3.5 | 35.0 | GO:0033691 | sialic acid binding(GO:0033691) |
| 3.3 | 19.9 | GO:0019003 | GDP binding(GO:0019003) |
| 3.3 | 19.7 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 3.3 | 55.7 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 3.2 | 13.0 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 3.0 | 48.0 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 3.0 | 18.0 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 3.0 | 17.8 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 2.9 | 23.5 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 2.9 | 23.1 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 2.8 | 38.7 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 2.8 | 30.3 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 2.7 | 13.6 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 2.7 | 10.8 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 2.7 | 26.9 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 2.6 | 94.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 2.6 | 41.5 | GO:0034452 | dynactin binding(GO:0034452) |
| 2.6 | 20.5 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 2.6 | 28.2 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 2.5 | 42.9 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 2.5 | 42.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 2.4 | 58.8 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 2.4 | 21.8 | GO:0043426 | MRF binding(GO:0043426) |
| 2.4 | 74.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 2.4 | 45.3 | GO:0051400 | BH domain binding(GO:0051400) |
| 2.3 | 7.0 | GO:0031755 | endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755) |
| 2.3 | 34.6 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 2.3 | 41.4 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 2.3 | 47.6 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 2.2 | 29.0 | GO:0032407 | MutSalpha complex binding(GO:0032407) |
| 2.2 | 17.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 2.2 | 11.0 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 2.2 | 96.3 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 2.2 | 39.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 2.1 | 10.6 | GO:0016936 | galactoside binding(GO:0016936) |
| 2.1 | 84.0 | GO:0043236 | laminin binding(GO:0043236) |
| 2.1 | 93.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 2.1 | 4.2 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 2.1 | 84.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 2.0 | 22.4 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 2.0 | 7.9 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 2.0 | 5.9 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 2.0 | 15.7 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 1.9 | 5.7 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 1.9 | 9.5 | GO:0047238 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238) |
| 1.9 | 22.8 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 1.9 | 35.7 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 1.9 | 13.0 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 1.8 | 10.7 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 1.8 | 26.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 1.8 | 26.5 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
| 1.7 | 45.4 | GO:0022829 | wide pore channel activity(GO:0022829) |
| 1.7 | 36.6 | GO:0043495 | protein anchor(GO:0043495) |
| 1.7 | 44.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 1.7 | 15.4 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 1.7 | 21.7 | GO:0030228 | lipoprotein particle receptor activity(GO:0030228) |
| 1.6 | 24.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 1.6 | 109.2 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 1.6 | 32.0 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 1.6 | 17.3 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 1.5 | 44.0 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 1.5 | 68.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.5 | 34.6 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 1.5 | 47.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 1.5 | 17.9 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 1.5 | 29.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 1.5 | 38.1 | GO:0046961 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 1.5 | 48.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 1.5 | 78.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 1.4 | 14.4 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 1.4 | 7.2 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 1.4 | 47.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 1.4 | 28.7 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 1.4 | 19.1 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 1.4 | 36.9 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 1.4 | 29.8 | GO:0035198 | miRNA binding(GO:0035198) |
| 1.3 | 23.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 1.3 | 15.6 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 1.2 | 54.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 1.2 | 4.9 | GO:0019107 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 1.2 | 20.8 | GO:0043274 | phospholipase binding(GO:0043274) |
| 1.2 | 3.7 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 1.2 | 4.7 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 1.2 | 9.4 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 1.2 | 15.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 1.2 | 11.7 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 1.2 | 15.1 | GO:0046790 | virion binding(GO:0046790) |
| 1.1 | 4.6 | GO:0001632 | leukotriene B4 receptor activity(GO:0001632) |
| 1.1 | 5.7 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 1.1 | 11.2 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 1.1 | 37.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 1.1 | 5.4 | GO:0004376 | glycolipid mannosyltransferase activity(GO:0004376) |
| 1.0 | 17.8 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 1.0 | 214.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 234.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.0 | 2.1 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 1.0 | 15.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 1.0 | 38.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 1.0 | 24.9 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.0 | 29.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 1.0 | 61.5 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.0 | 2.9 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.9 | 7.3 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.9 | 3.6 | GO:0015119 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.9 | 9.7 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.9 | 57.3 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.9 | 61.6 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.8 | 28.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.8 | 5.8 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.8 | 74.5 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.8 | 3.0 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.7 | 18.7 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.7 | 14.8 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.7 | 4.6 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) sequence-specific mRNA binding(GO:1990825) |
| 0.6 | 16.1 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.6 | 2.5 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.6 | 15.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.6 | 41.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.6 | 170.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.6 | 9.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.6 | 29.9 | GO:0008137 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.6 | 10.0 | GO:0098847 | sequence-specific single stranded DNA binding(GO:0098847) |
| 0.5 | 10.3 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.5 | 6.4 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.5 | 170.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 62.3 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.5 | 6.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.5 | 2.6 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.5 | 3.0 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.5 | 6.9 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.5 | 11.2 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.5 | 59.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.5 | 23.2 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.5 | 13.2 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.5 | 120.0 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.5 | 23.2 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.5 | 42.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.4 | 30.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.4 | 1.7 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.4 | 1.3 | GO:0005167 | neurotrophin TRK receptor binding(GO:0005167) |
| 0.4 | 12.2 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.4 | 8.1 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.4 | 2.8 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
| 0.4 | 1.6 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.4 | 3.9 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.4 | 1.9 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.4 | 4.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.4 | 2.6 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.4 | 45.2 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.4 | 2.9 | GO:0003696 | satellite DNA binding(GO:0003696) centromeric DNA binding(GO:0019237) |
| 0.4 | 14.4 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.4 | 9.9 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.3 | 6.4 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
| 0.3 | 28.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.3 | 8.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.3 | 7.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.3 | 2.7 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.3 | 9.0 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.3 | 0.8 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.3 | 0.8 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.3 | 1.5 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.3 | 3.5 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.2 | 3.7 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.2 | 1.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.2 | 3.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 4.1 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.2 | 3.1 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.2 | 1.3 | GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929) |
| 0.2 | 4.0 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.2 | 2.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 4.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.2 | 2.1 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.2 | 2.3 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.2 | 3.8 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.1 | 7.2 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 3.5 | GO:0044390 | ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.1 | 7.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 2.9 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 8.2 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.1 | 1.7 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.1 | 2.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 29.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 1.4 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 2.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 7.5 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 0.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.0 | 0.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 1.1 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.0 | 1.5 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 589.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 5.6 | 244.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 4.5 | 416.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 4.2 | 125.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 3.8 | 11.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 3.4 | 47.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 3.1 | 266.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 3.0 | 146.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.9 | 197.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 2.5 | 77.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 2.1 | 8.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 2.0 | 54.8 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 1.9 | 31.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 1.8 | 59.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 1.8 | 139.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.8 | 54.9 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 1.8 | 40.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 1.8 | 26.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 1.7 | 195.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 1.7 | 26.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 1.5 | 37.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 1.5 | 96.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 1.5 | 178.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.5 | 64.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 1.5 | 36.7 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 1.4 | 10.8 | ST STAT3 PATHWAY | STAT3 Pathway |
| 1.1 | 28.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.9 | 14.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.9 | 27.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.9 | 24.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.8 | 6.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.8 | 16.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.8 | 25.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.7 | 14.9 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.7 | 14.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.7 | 42.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.7 | 21.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.6 | 9.0 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.6 | 8.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.6 | 36.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.5 | 50.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.5 | 41.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.5 | 11.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.5 | 17.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.5 | 5.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.4 | 17.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 32.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 1.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.3 | 4.1 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 8.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 6.7 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.2 | 6.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.2 | 5.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 0.6 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 30.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 2.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 0.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 0.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 3.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 10.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 3.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 2.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 1.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 0.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 1.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.5 | 323.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 9.5 | 47.6 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 7.6 | 84.0 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 5.5 | 303.2 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 5.3 | 47.6 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 5.3 | 232.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 4.9 | 74.0 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 4.7 | 18.6 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 4.6 | 68.4 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 4.4 | 144.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 3.1 | 87.7 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 3.1 | 258.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 2.9 | 64.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 2.6 | 37.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 2.5 | 81.1 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 2.4 | 29.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 2.4 | 34.0 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 2.4 | 57.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 2.3 | 9.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 2.3 | 72.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 2.2 | 15.7 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 2.2 | 44.4 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 2.2 | 312.9 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 2.1 | 113.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 2.0 | 38.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 2.0 | 29.9 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 2.0 | 59.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 2.0 | 49.0 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 2.0 | 64.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 1.9 | 28.6 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 1.8 | 27.6 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 1.7 | 65.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 1.7 | 49.7 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 1.7 | 13.2 | REACTOME PURINE METABOLISM | Genes involved in Purine metabolism |
| 1.6 | 32.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.6 | 81.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.6 | 11.0 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 1.5 | 250.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.5 | 16.9 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 1.5 | 19.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 1.5 | 70.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.5 | 108.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.4 | 20.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 1.4 | 72.1 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 1.3 | 11.4 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 1.2 | 7.3 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 1.2 | 23.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.1 | 27.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.1 | 21.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 1.1 | 43.8 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 1.0 | 114.6 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 1.0 | 9.1 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 1.0 | 26.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 1.0 | 14.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.0 | 26.7 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.9 | 20.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.9 | 14.9 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.8 | 24.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.8 | 13.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.8 | 10.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.8 | 13.2 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.8 | 20.4 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.8 | 135.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 10.2 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.8 | 14.7 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.7 | 9.0 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.7 | 7.2 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.7 | 53.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.7 | 11.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.6 | 14.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.6 | 40.7 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.6 | 40.7 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.5 | 12.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 11.0 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.5 | 14.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.5 | 10.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.5 | 16.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.5 | 7.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.5 | 10.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.4 | 4.7 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.4 | 17.3 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.4 | 10.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.4 | 4.4 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.4 | 12.8 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.3 | 4.9 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.3 | 9.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 10.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.3 | 4.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.3 | 4.6 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.3 | 7.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 5.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 5.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 6.4 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.2 | 4.9 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.2 | 9.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 9.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 11.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 4.4 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.2 | 7.1 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.2 | 12.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 4.0 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 7.8 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.2 | 7.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 1.7 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 8.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 5.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 4.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 13.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.4 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.1 | 3.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.4 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 4.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.1 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 2.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 0.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.6 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.5 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |