ISMARA results: SPIB

Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for SPIB

Z-value: 3.23

Motif logo

Transcription factors associated with SPIB

Gene Symbol	Gene ID	Gene Info
SPIB Ensembl NCBI GeneCards UniProt	ENSG00000269404.7	SPIB

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SPIB	hg38_v1_chr19_+_50418930_50418958	0.43	2.4e-11	Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

View svg image
View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr1_-_160711803 Show fit	124.73	ENST00000368045.3 ENST00000368046.8 ENST00000613788.1	CD48 Ensembl NCBI GeneCards UniProt Show fit	CD48 molecule
chr1_-_30757767 Show fit	88.85	ENST00000294507.4	LAPTM5 Ensembl NCBI GeneCards UniProt Show fit	lysosomal protein transmembrane 5
chr12_-_14961559 Show fit	88.75	ENST00000228945.9 ENST00000541546.5	ARHGDIB Ensembl NCBI GeneCards UniProt Show fit	Rho GDP dissociation inhibitor beta
chr16_+_30183595 Show fit	84.26	ENST00000219150.10 ENST00000570045.5 ENST00000565497.5 ENST00000570244.5	CORO1A Ensembl NCBI GeneCards UniProt Show fit	coronin 1A
chr3_-_121660892 Show fit	82.09	ENST00000428394.6 ENST00000314583.8	HCLS1 Ensembl NCBI GeneCards UniProt Show fit	hematopoietic cell-specific Lyn substrate 1
chr5_+_169637241 Show fit	72.10	ENST00000520908.7	DOCK2 Ensembl NCBI GeneCards UniProt Show fit	dedicator of cytokinesis 2
chr22_+_36913620 Show fit	66.28	ENST00000403662.8 ENST00000262825.9	CSF2RB Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 2 receptor subunit beta
chr13_+_30735523 Show fit	63.22	ENST00000380490.5	ALOX5AP Ensembl NCBI GeneCards UniProt Show fit	arachidonate 5-lipoxygenase activating protein
chr17_-_31314040 Show fit	59.36	ENST00000330927.5	EVI2B Ensembl NCBI GeneCards UniProt Show fit	ecotropic viral integration site 2B
chr13_+_30713477 Show fit	57.70	ENST00000617770.4	ALOX5AP Ensembl NCBI GeneCards UniProt Show fit	arachidonate 5-lipoxygenase activating protein
chr7_+_74773962 Show fit	57.28	ENST00000289473.10	NCF1 Ensembl NCBI GeneCards UniProt Show fit	neutrophil cytosolic factor 1
chrX_-_47629845 Show fit	54.53	ENST00000469388.1 ENST00000396992.8 ENST00000377005.6	CFP Ensembl NCBI GeneCards UniProt Show fit	complement factor properdin
chr1_+_209768482 Show fit	53.88	ENST00000367023.5	TRAF3IP3 Ensembl NCBI GeneCards UniProt Show fit	TRAF3 interacting protein 3
chr11_-_64745331 Show fit	51.91	ENST00000377489.5 ENST00000354024.7	RASGRP2 Ensembl NCBI GeneCards UniProt Show fit	RAS guanyl releasing protein 2
chr2_+_68365274 Show fit	50.94	ENST00000234313.8	PLEK Ensembl NCBI GeneCards UniProt Show fit	pleckstrin
chr21_-_44920892 Show fit	48.72	ENST00000397846.7 ENST00000652462.1 ENST00000302347.10 ENST00000524251.1	ITGB2 Ensembl NCBI GeneCards UniProt Show fit	integrin subunit beta 2
chr20_-_64079479 Show fit	48.23	ENST00000395042.2	RGS19 Ensembl NCBI GeneCards UniProt Show fit	regulator of G protein signaling 19
chr20_-_64079906 Show fit	48.16	ENST00000332298.9	RGS19 Ensembl NCBI GeneCards UniProt Show fit	regulator of G protein signaling 19
chr21_-_44920855 Show fit	47.90	ENST00000397854.7	ITGB2 Ensembl NCBI GeneCards UniProt Show fit	integrin subunit beta 2
chr2_+_143129379 Show fit	47.74	ENST00000295095.11	ARHGAP15 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 15
chr11_-_64744811 Show fit	47.25	ENST00000377497.7 ENST00000377487.5 ENST00000430645.1	RASGRP2 Ensembl NCBI GeneCards UniProt Show fit	RAS guanyl releasing protein 2
chr1_+_26317950 Show fit	46.84	ENST00000374213.3	CD52 Ensembl NCBI GeneCards UniProt Show fit	CD52 molecule
chr1_-_153946652 Show fit	46.81	ENST00000361217.9	DENND4B Ensembl NCBI GeneCards UniProt Show fit	DENN domain containing 4B
chr17_-_31314066 Show fit	46.08	ENST00000577894.1	EVI2B Ensembl NCBI GeneCards UniProt Show fit	ecotropic viral integration site 2B
chr6_+_31615215 Show fit	45.75	ENST00000337917.11 ENST00000376059.8	AIF1 Ensembl NCBI GeneCards UniProt Show fit	allograft inflammatory factor 1
chr6_-_24935942 Show fit	44.96	ENST00000645100.1 ENST00000643898.2 ENST00000613507.4	RIPOR2 Ensembl NCBI GeneCards UniProt Show fit	RHO family interacting cell polarization regulator 2
chr22_-_37244237 Show fit	44.54	ENST00000401529.3 ENST00000249071.11	RAC2 Ensembl NCBI GeneCards UniProt Show fit	Rac family small GTPase 2
chr12_+_25052732 Show fit	41.46	ENST00000547044.5	IRAG2 Ensembl NCBI GeneCards UniProt Show fit	inositol 1,4,5-triphosphate receptor associated 2
chr19_-_10335773 Show fit	39.07	ENST00000592439.1	ICAM3 Ensembl NCBI GeneCards UniProt Show fit	intercellular adhesion molecule 3
chr1_+_161505412 Show fit	37.05	ENST00000367972.8	FCGR2A Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor IIa
chr11_-_3837858 Show fit	36.95	ENST00000396979.1	RHOG Ensembl NCBI GeneCards UniProt Show fit	ras homolog family member G
chr12_+_6951271 Show fit	36.82	ENST00000456013.5	PTPN6 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase non-receptor type 6
chr12_+_6951345 Show fit	36.76	ENST00000318974.14 ENST00000541698.5 ENST00000542462.1	PTPN6 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase non-receptor type 6
chr12_+_25052634 Show fit	36.63	ENST00000548766.5	IRAG2 Ensembl NCBI GeneCards UniProt Show fit	inositol 1,4,5-triphosphate receptor associated 2
chr7_-_36724380 Show fit	35.38	ENST00000617267.4	AOAH Ensembl NCBI GeneCards UniProt Show fit	acyloxyacyl hydrolase
chr7_-_36724457 Show fit	35.22	ENST00000617537.5 ENST00000435386.1	AOAH Ensembl NCBI GeneCards UniProt Show fit	acyloxyacyl hydrolase
chr12_+_8123837 Show fit	35.15	ENST00000345999.9 ENST00000352620.9 ENST00000360500.5	CLEC4A Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain family 4 member A
chr7_-_36724543 Show fit	34.24	ENST00000612871.4	AOAH Ensembl NCBI GeneCards UniProt Show fit	acyloxyacyl hydrolase
chr19_+_48325323 Show fit	34.22	ENST00000596315.5	EMP3 Ensembl NCBI GeneCards UniProt Show fit	epithelial membrane protein 3
chr19_+_48325522 Show fit	34.14	ENST00000594198.1 ENST00000270221.11 ENST00000597279.5 ENST00000593437.1	EMP3 Ensembl NCBI GeneCards UniProt Show fit	epithelial membrane protein 3
chr11_-_64744993 Show fit	34.13	ENST00000377485.5	RASGRP2 Ensembl NCBI GeneCards UniProt Show fit	RAS guanyl releasing protein 2
chr6_+_31586269 Show fit	33.80	ENST00000438075.7	LST1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte specific transcript 1
chr7_+_139829153 Show fit	32.78	ENST00000652056.1	TBXAS1 Ensembl NCBI GeneCards UniProt Show fit	thromboxane A synthase 1
chr11_-_67437670 Show fit	32.74	ENST00000326294.4	PTPRCAP Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase receptor type C associated protein
chr3_-_151329539 Show fit	32.21	ENST00000325602.6	P2RY13 Ensembl NCBI GeneCards UniProt Show fit	purinergic receptor P2Y13
chr10_+_11165475 Show fit	32.20	ENST00000609692.5 ENST00000354897.3	CELF2 Ensembl NCBI GeneCards UniProt Show fit	CUGBP Elav-like family member 2
chr14_-_22819721 Show fit	31.50	ENST00000554517.5 ENST00000285850.11 ENST00000397529.6 ENST00000555702.5	SLC7A7 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 7 member 7
chr19_+_45469841 Show fit	31.46	ENST00000592811.5 ENST00000586615.5	FOSB Ensembl NCBI GeneCards UniProt Show fit	FosB proto-oncogene, AP-1 transcription factor subunit
chr17_+_42289213 Show fit	31.33	ENST00000677301.1	STAT5A Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 5A
chr12_+_25052512 Show fit	30.81	ENST00000557489.5 ENST00000354454.7 ENST00000536173.5	IRAG2 Ensembl NCBI GeneCards UniProt Show fit	inositol 1,4,5-triphosphate receptor associated 2
chr9_+_90801909 Show fit	30.26	ENST00000375747.5	SYK Ensembl NCBI GeneCards UniProt Show fit	spleen associated tyrosine kinase
chr6_+_31586124 Show fit	30.17	ENST00000418507.6 ENST00000376096.5 ENST00000376099.5 ENST00000376110.7	LST1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte specific transcript 1
chr1_+_161581339 Show fit	30.12	ENST00000543859.5 ENST00000611236.1	FCGR2C Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor IIc (gene/pseudogene)
chr12_+_8123899 Show fit	30.02	ENST00000641376.1	CLEC4A Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain family 4 member A
chr9_+_90801757 Show fit	29.94	ENST00000375751.8 ENST00000375754.9	SYK Ensembl NCBI GeneCards UniProt Show fit	spleen associated tyrosine kinase
chr7_+_139829242 Show fit	29.93	ENST00000455353.6 ENST00000458722.6 ENST00000448866.7 ENST00000411653.6	TBXAS1 Ensembl NCBI GeneCards UniProt Show fit	thromboxane A synthase 1
chr6_-_132757883 Show fit	29.83	ENST00000525289.5 ENST00000326499.11	VNN2 Ensembl NCBI GeneCards UniProt Show fit	vanin 2
chr17_+_7558774 Show fit	29.75	ENST00000396545.4	TNFSF13 Ensembl NCBI GeneCards UniProt Show fit	TNF superfamily member 13
chr2_-_230219944 Show fit	29.67	ENST00000455674.2 ENST00000392048.7 ENST00000258381.11 ENST00000358662.9 ENST00000258382.10	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr6_-_132513045 Show fit	29.50	ENST00000367941.7 ENST00000367937.4	STX7 Ensembl NCBI GeneCards UniProt Show fit	syntaxin 7
chr6_+_31587002 Show fit	29.29	ENST00000376090.6	LST1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte specific transcript 1
chr4_+_102501885 Show fit	29.08	ENST00000505458.5	NFKB1 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor kappa B subunit 1
chr2_+_233059838 Show fit	29.00	ENST00000359570.9	INPP5D Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase D
chr6_+_31587049 Show fit	28.74	ENST00000376089.6 ENST00000396112.6	LST1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte specific transcript 1
chr15_+_76995118 Show fit	28.67	ENST00000558012.6 ENST00000379595.7	PSTPIP1 Ensembl NCBI GeneCards UniProt Show fit	proline-serine-threonine phosphatase interacting protein 1
chr10_-_119542683 Show fit	28.57	ENST00000369103.3	RGS10 Ensembl NCBI GeneCards UniProt Show fit	regulator of G protein signaling 10
chr19_+_6772699 Show fit	28.30	ENST00000602142.6 ENST00000304076.6 ENST00000596764.5	VAV1 Ensembl NCBI GeneCards UniProt Show fit	vav guanine nucleotide exchange factor 1
chr2_-_230219902 Show fit	27.89	ENST00000409815.6	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr22_-_37244417 Show fit	27.70	ENST00000405484.5 ENST00000441619.5 ENST00000406508.5	RAC2 Ensembl NCBI GeneCards UniProt Show fit	Rac family small GTPase 2
chr19_+_41877267 Show fit	25.90	ENST00000221972.8 ENST00000597454.1 ENST00000444740.2	CD79A Ensembl NCBI GeneCards UniProt Show fit	CD79a molecule
chr2_+_233060295 Show fit	25.45	ENST00000445964.6	INPP5D Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase D
chr19_+_35154914 Show fit	25.38	ENST00000423817.7	FXYD5 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 5
chr1_+_161505438 Show fit	25.28	ENST00000271450.12	FCGR2A Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor IIa
chr12_-_7503744 Show fit	25.24	ENST00000396620.7 ENST00000432237.3	CD163 Ensembl NCBI GeneCards UniProt Show fit	CD163 molecule
chr8_+_73991345 Show fit	25.19	ENST00000284818.7 ENST00000518893.1	LY96 Ensembl NCBI GeneCards UniProt Show fit	lymphocyte antigen 96
chr17_+_7558712 Show fit	25.15	ENST00000338784.9 ENST00000625791.2	TNFSF13 Ensembl NCBI GeneCards UniProt Show fit	TNF superfamily member 13
chr11_-_47378391 Show fit	24.98	ENST00000227163.8	SPI1 Ensembl NCBI GeneCards UniProt Show fit	Spi-1 proto-oncogene
chr10_+_95756150 Show fit	24.59	ENST00000371205.5	ENTPD1 Ensembl NCBI GeneCards UniProt Show fit	ectonucleoside triphosphate diphosphohydrolase 1
chr17_+_7558465 Show fit	24.00	ENST00000349228.8	TNFSF13 Ensembl NCBI GeneCards UniProt Show fit	TNF superfamily member 13
chr14_+_88005128 Show fit	23.95	ENST00000267549.5	GPR65 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 65
chr19_-_13102848 Show fit	23.68	ENST00000264824.5	LYL1 Ensembl NCBI GeneCards UniProt Show fit	LYL1 basic helix-loop-helix family member
chr19_+_7348930 Show fit	23.58	ENST00000668164.2	ARHGEF18 Ensembl NCBI GeneCards UniProt Show fit	Rho/Rac guanine nucleotide exchange factor 18
chr10_+_11164961 Show fit	23.47	ENST00000399850.7 ENST00000417956.6	CELF2 Ensembl NCBI GeneCards UniProt Show fit	CUGBP Elav-like family member 2
chr6_+_292461 Show fit	23.11	ENST00000605035.5 ENST00000605863.5 ENST00000419235.7	DUSP22 Ensembl NCBI GeneCards UniProt Show fit	dual specificity phosphatase 22
chr1_+_161663147 Show fit	22.93	ENST00000236937.13 ENST00000367961.8 ENST00000358671.9	FCGR2B Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor IIb
chrX_-_130110679 Show fit	22.57	ENST00000335997.11	ELF4 Ensembl NCBI GeneCards UniProt Show fit	E74 like ETS transcription factor 4
chr5_-_140633690 Show fit	22.54	ENST00000512545.1 ENST00000401743.6	CD14 Ensembl NCBI GeneCards UniProt Show fit	CD14 molecule
chr3_+_122055355 Show fit	22.53	ENST00000330540.7 ENST00000469710.5 ENST00000493101.5	CD86 Ensembl NCBI GeneCards UniProt Show fit	CD86 molecule
chr17_-_75393741 Show fit	22.47	ENST00000578961.5 ENST00000392564.5	GRB2 Ensembl NCBI GeneCards UniProt Show fit	growth factor receptor bound protein 2
chr11_-_47378527 Show fit	22.16	ENST00000378538.8	SPI1 Ensembl NCBI GeneCards UniProt Show fit	Spi-1 proto-oncogene
chr12_-_7503841 Show fit	21.91	ENST00000359156.8	CD163 Ensembl NCBI GeneCards UniProt Show fit	CD163 molecule
chr19_+_54630497 Show fit	21.80	ENST00000396332.8 ENST00000427581.6	LILRB1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte immunoglobulin like receptor B1
chr5_+_55102635 Show fit	21.67	ENST00000274306.7	GZMA Ensembl NCBI GeneCards UniProt Show fit	granzyme A
chr17_-_75393656 Show fit	21.16	ENST00000392563.5	GRB2 Ensembl NCBI GeneCards UniProt Show fit	growth factor receptor bound protein 2
chr12_+_54497712 Show fit	21.16	ENST00000293373.11	NCKAP1L Ensembl NCBI GeneCards UniProt Show fit	NCK associated protein 1 like
chr19_+_54630410 Show fit	21.07	ENST00000396327.7 ENST00000324602.12	LILRB1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte immunoglobulin like receptor B1
chr6_+_31586835 Show fit	21.04	ENST00000211921.11	LST1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte specific transcript 1
chr8_-_100722174 Show fit	20.82	ENST00000677380.1 ENST00000677478.1	PABPC1 Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein cytoplasmic 1
chr8_-_100722036 Show fit	20.43	ENST00000518196.5 ENST00000519004.5 ENST00000519363.1 ENST00000318607.10 ENST00000520142.2	PABPC1 Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein cytoplasmic 1
chrX_+_11760087 Show fit	20.26	ENST00000649271.1	MSL3 Ensembl NCBI GeneCards UniProt Show fit	MSL complex subunit 3
chr1_+_89821921 Show fit	20.02	ENST00000394593.7	LRRC8D Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 8 VRAC subunit D
chr1_+_149782671 Show fit	19.70	ENST00000444948.5 ENST00000369168.5	FCGR1A Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor Ia
chr6_+_31586680 Show fit	19.59	ENST00000339530.8	LST1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte specific transcript 1
chrX_-_130110479 Show fit	19.26	ENST00000308167.10	ELF4 Ensembl NCBI GeneCards UniProt Show fit	E74 like ETS transcription factor 4
chr15_-_65517244 Show fit	19.22	ENST00000341861.9	DPP8 Ensembl NCBI GeneCards UniProt Show fit	dipeptidyl peptidase 8
chr17_+_7558258 Show fit	18.79	ENST00000483039.5 ENST00000380535.8 ENST00000396542.5	TNFSF13 Ensembl NCBI GeneCards UniProt Show fit	TNF superfamily member 13
chr11_-_65121780 Show fit	18.77	ENST00000525297.5 ENST00000529259.1	FAU Ensembl NCBI GeneCards UniProt Show fit	FAU ubiquitin like and ribosomal protein S30 fusion
chrX_+_11760035 Show fit	18.66	ENST00000482871.6 ENST00000648013.1	MSL3 Ensembl NCBI GeneCards UniProt Show fit	MSL complex subunit 3
chr3_-_52239082 Show fit	18.00	ENST00000499914.2 ENST00000678838.1 ENST00000305533.10 ENST00000678330.1	TWF2 Ensembl NCBI GeneCards UniProt Show fit	twinfilin actin binding protein 2
chr8_-_100721851 Show fit	17.93	ENST00000522658.6	PABPC1 Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein cytoplasmic 1
chr15_-_65517653 Show fit	17.87	ENST00000559526.5 ENST00000358939.8 ENST00000560665.1 ENST00000300141.11	DPP8 Ensembl NCBI GeneCards UniProt Show fit	dipeptidyl peptidase 8
chrX_+_24054931 Show fit	17.61	ENST00000253039.9 ENST00000423068.1	EIF2S3 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 2 subunit gamma
chr1_+_121087343 Show fit	17.36	ENST00000616817.4 ENST00000623603.3 ENST00000369384.9 ENST00000369383.8 ENST00000369178.5	FCGR1B Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor Ib
chr22_-_37484505 Show fit	17.32	ENST00000442496.1	MFNG Ensembl NCBI GeneCards UniProt Show fit	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_-_41286665 Show fit	17.25	ENST00000589614.5 ENST00000244709.9 ENST00000334475.10 ENST00000591620.1	TREM1 Ensembl NCBI GeneCards UniProt Show fit	triggering receptor expressed on myeloid cells 1
chr11_-_47378494 Show fit	17.23	ENST00000533030.1	SPI1 Ensembl NCBI GeneCards UniProt Show fit	Spi-1 proto-oncogene
chr3_-_16513643 Show fit	17.21	ENST00000334133.9	RFTN1 Ensembl NCBI GeneCards UniProt Show fit	raftlin, lipid raft linker 1
chr2_+_161231078 Show fit	17.15	ENST00000439442.1	TANK Ensembl NCBI GeneCards UniProt Show fit	TRAF family member associated NFKB activator
chr14_+_101761786 Show fit	16.92	ENST00000422945.6 ENST00000554442.5 ENST00000556260.6 ENST00000328724.9 ENST00000557268.5	PPP2R5C Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2 regulatory subunit B'gamma
chr1_+_38991239 Show fit	16.87	ENST00000432648.8 ENST00000446189.6 ENST00000372984.8	AKIRIN1 Ensembl NCBI GeneCards UniProt Show fit	akirin 1
chr17_+_82237134 Show fit	16.80	ENST00000583025.1	SLC16A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 16 member 3
chr2_-_74178802 Show fit	16.74	ENST00000396049.5	MOB1A Ensembl NCBI GeneCards UniProt Show fit	MOB kinase activator 1A
chrX_+_110003095 Show fit	16.34	ENST00000372073.5 ENST00000372068.7 ENST00000288381.4	TMEM164 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 164
chr10_+_95755737 Show fit	16.32	ENST00000543964.6	ENTPD1 Ensembl NCBI GeneCards UniProt Show fit	ectonucleoside triphosphate diphosphohydrolase 1
chr19_+_51225059 Show fit	16.19	ENST00000436584.6 ENST00000421133.6 ENST00000262262.5 ENST00000391796.7	CD33 Ensembl NCBI GeneCards UniProt Show fit	CD33 molecule
chr12_+_111405861 Show fit	16.18	ENST00000341259.7	SH2B3 Ensembl NCBI GeneCards UniProt Show fit	SH2B adaptor protein 3
chr1_+_159302321 Show fit	15.74	ENST00000368114.1	FCER1A Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgE receptor Ia
chr19_-_10119886 Show fit	15.67	ENST00000587146.5 ENST00000253108.9 ENST00000588709.5	EIF3G Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 3 subunit G
chr1_-_159923717 Show fit	15.27	ENST00000368096.5	TAGLN2 Ensembl NCBI GeneCards UniProt Show fit	transgelin 2
chr11_-_65122057 Show fit	15.11	ENST00000531743.5 ENST00000527548.5 ENST00000526555.5 ENST00000529639.6 ENST00000279259.7	FAU Ensembl NCBI GeneCards UniProt Show fit	FAU ubiquitin like and ribosomal protein S30 fusion
chr15_-_65517704 Show fit	15.03	ENST00000321147.10	DPP8 Ensembl NCBI GeneCards UniProt Show fit	dipeptidyl peptidase 8
chr3_+_46354072 Show fit	14.98	ENST00000445132.3 ENST00000421659.1	CCR2 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine receptor 2
chr3_+_122077850 Show fit	14.92	ENST00000482356.5 ENST00000393627.6	CD86 Ensembl NCBI GeneCards UniProt Show fit	CD86 molecule
chr11_-_64778747 Show fit	14.71	ENST00000227503.13 ENST00000377394.7 ENST00000334944.9	SF1 Ensembl NCBI GeneCards UniProt Show fit	splicing factor 1
chr19_-_54242751 Show fit	14.69	ENST00000245621.6 ENST00000396365.6	LILRA6 Ensembl NCBI GeneCards UniProt Show fit	leukocyte immunoglobulin like receptor A6
chr18_-_50287570 Show fit	14.65	ENST00000586837.1 ENST00000412036.6 ENST00000589940.5 ENST00000587396.1 ENST00000591474.5 ENST00000285106.11	CXXC1 Ensembl NCBI GeneCards UniProt Show fit	CXXC finger protein 1
chr17_+_7558296 Show fit	14.53	ENST00000438470.5 ENST00000436057.5	TNFSF13 Ensembl NCBI GeneCards UniProt Show fit	TNF superfamily member 13
chr10_-_96271508 Show fit	14.52	ENST00000427367.6 ENST00000413476.6 ENST00000371176.6	BLNK Ensembl NCBI GeneCards UniProt Show fit	B cell linker
chr8_-_100721942 Show fit	14.46	ENST00000522387.5	PABPC1 Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein cytoplasmic 1
chr17_+_67377413 Show fit	14.18	ENST00000580974.5	PITPNC1 Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol transfer protein cytoplasmic 1
chr2_+_113173950 Show fit	13.90	ENST00000245796.11 ENST00000441564.7	PSD4 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin and Sec7 domain containing 4
chr17_+_67377272 Show fit	13.90	ENST00000581322.6 ENST00000299954.13	PITPNC1 Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol transfer protein cytoplasmic 1
chr19_+_2476118 Show fit	13.87	ENST00000215631.9 ENST00000587345.1	GADD45B Ensembl NCBI GeneCards UniProt Show fit	growth arrest and DNA damage inducible beta
chr22_-_31630825 Show fit	13.23	ENST00000397500.5	PISD Ensembl NCBI GeneCards UniProt Show fit	phosphatidylserine decarboxylase
chr11_-_65122177 Show fit	13.22	ENST00000434372.2	FAU Ensembl NCBI GeneCards UniProt Show fit	FAU ubiquitin like and ribosomal protein S30 fusion
chr19_-_54222978 Show fit	13.16	ENST00000245620.13 ENST00000346401.10 ENST00000445347.1	LILRB3 Ensembl NCBI GeneCards UniProt Show fit	leukocyte immunoglobulin like receptor B3
chr2_-_207167220 Show fit	13.09	ENST00000421199.5 ENST00000457962.5	KLF7 Ensembl NCBI GeneCards UniProt Show fit	Kruppel like factor 7
chr1_-_150579738 Show fit	13.04	ENST00000620947.4	MCL1 Ensembl NCBI GeneCards UniProt Show fit	MCL1 apoptosis regulator, BCL2 family member
chr5_+_112976757 Show fit	12.70	ENST00000389063.3	DCP2 Ensembl NCBI GeneCards UniProt Show fit	decapping mRNA 2
chrX_-_75156272 Show fit	12.62	ENST00000620875.5 ENST00000669573.1 ENST00000339447.8 ENST00000645829.3 ENST00000529949.5 ENST00000373394.8 ENST00000253577.9 ENST00000644766.1 ENST00000534524.5	ABCB7 Ensembl NCBI GeneCards UniProt Show fit	ATP binding cassette subfamily B member 7
chr2_+_201260496 Show fit	12.60	ENST00000323492.11	CASP8 Ensembl NCBI GeneCards UniProt Show fit	caspase 8
chr10_+_112374110 Show fit	12.35	ENST00000354655.9	ACSL5 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase long chain family member 5
chr6_+_15246054 Show fit	12.33	ENST00000341776.7	JARID2 Ensembl NCBI GeneCards UniProt Show fit	jumonji and AT-rich interaction domain containing 2
chr18_-_50287816 Show fit	12.23	ENST00000589548.6 ENST00000673786.1	CXXC1 Ensembl NCBI GeneCards UniProt Show fit	CXXC finger protein 1
chr6_+_31586859 Show fit	12.21	ENST00000433492.5	LST1 Ensembl NCBI GeneCards UniProt Show fit	leukocyte specific transcript 1
chr18_-_11908330 Show fit	12.17	ENST00000344987.11 ENST00000588103.5 ENST00000588191.5 ENST00000317235.11 ENST00000309976.13 ENST00000588186.5 ENST00000589267.5	MPPE1 Ensembl NCBI GeneCards UniProt Show fit	metallophosphoesterase 1
chr19_-_3786254 Show fit	12.12	ENST00000585778.5	MATK Ensembl NCBI GeneCards UniProt Show fit	megakaryocyte-associated tyrosine kinase
chr22_-_31630805 Show fit	12.07	ENST00000266095.9	PISD Ensembl NCBI GeneCards UniProt Show fit	phosphatidylserine decarboxylase
chrX_+_70133433 Show fit	11.80	ENST00000356413.5 ENST00000342206.10	IGBP1 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin binding protein 1
chr19_-_10119863 Show fit	11.76	ENST00000589454.5	EIF3G Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 3 subunit G
chr1_+_43974902 Show fit	11.65	ENST00000532642.5 ENST00000236067.8 ENST00000471859.6 ENST00000472174.7	ATP6V0B Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting V0 subunit b
chrX_+_11759604 Show fit	11.63	ENST00000649602.1 ENST00000650215.1 ENST00000649685.1 ENST00000649649.1 ENST00000380693.8 ENST00000380692.7 ENST00000650628.1 ENST00000649851.1 ENST00000421368.3	MSL3 Ensembl NCBI GeneCards UniProt Show fit	MSL complex subunit 3
chr3_+_122077776 Show fit	11.28	ENST00000264468.9	CD86 Ensembl NCBI GeneCards UniProt Show fit	CD86 molecule
chr9_-_35618367 Show fit	11.23	ENST00000378431.5 ENST00000378430.3 ENST00000259633.9	CD72 Ensembl NCBI GeneCards UniProt Show fit	CD72 molecule
chr1_-_160647037 Show fit	11.22	ENST00000302035.11	SLAMF1 Ensembl NCBI GeneCards UniProt Show fit	signaling lymphocytic activation molecule family member 1
chr5_+_35856883 Show fit	11.15	ENST00000506850.5 ENST00000303115.8 ENST00000511982.1	IL7R Ensembl NCBI GeneCards UniProt Show fit	interleukin 7 receptor
chr4_+_102501298 Show fit	10.99	ENST00000394820.8 ENST00000226574.9 ENST00000511926.5 ENST00000507079.5	NFKB1 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor kappa B subunit 1
chr18_-_11908273 Show fit	10.84	ENST00000592977.5 ENST00000590501.5 ENST00000588072.6 ENST00000586844.5	MPPE1 Ensembl NCBI GeneCards UniProt Show fit	metallophosphoesterase 1
chr2_+_126656128 Show fit	10.65	ENST00000259254.9 ENST00000409836.3 ENST00000356887.12	GYPC Ensembl NCBI GeneCards UniProt Show fit	glycophorin C (Gerbich blood group)
chr19_+_17747737 Show fit	10.65	ENST00000600676.5 ENST00000600209.5 ENST00000596309.5 ENST00000598539.5 ENST00000597474.5 ENST00000593385.5 ENST00000598067.5 ENST00000593833.5	FCHO1 Ensembl NCBI GeneCards UniProt Show fit	FCH and mu domain containing endocytic adaptor 1
chr15_+_58987652 Show fit	10.64	ENST00000348370.9 ENST00000559160.1	RNF111 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 111
chrX_+_110002635 Show fit	10.43	ENST00000372072.7	TMEM164 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 164
chr14_+_101809795 Show fit	10.43	ENST00000350249.7 ENST00000557621.5 ENST00000556946.1	PPP2R5C Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2 regulatory subunit B'gamma
chr21_+_33266350 Show fit	10.37	ENST00000290200.7	IL10RB Ensembl NCBI GeneCards UniProt Show fit	interleukin 10 receptor subunit beta
chr11_-_60952067 Show fit	10.36	ENST00000681275.1	SLC15A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 15 member 3
chr17_+_43483949 Show fit	10.36	ENST00000540306.5 ENST00000262415.8	DHX8 Ensembl NCBI GeneCards UniProt Show fit	DEAH-box helicase 8
chr1_+_89821003 Show fit	10.27	ENST00000525774.5 ENST00000337338.9	LRRC8D Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 8 VRAC subunit D
chr11_-_60952559 Show fit	10.18	ENST00000538739.2	SLC15A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 15 member 3
chr19_-_3786363 Show fit	10.10	ENST00000310132.11	MATK Ensembl NCBI GeneCards UniProt Show fit	megakaryocyte-associated tyrosine kinase
chr1_+_40040219 Show fit	10.06	ENST00000372797.7 ENST00000372802.5 ENST00000449311.5	CAP1 Ensembl NCBI GeneCards UniProt Show fit	cyclase associated actin cytoskeleton regulatory protein 1
chr10_-_63269057 Show fit	10.03	ENST00000542921.5	JMJD1C Ensembl NCBI GeneCards UniProt Show fit	jumonji domain containing 1C
chr16_+_30949054 Show fit	10.03	ENST00000318663.5 ENST00000566237.1 ENST00000562699.1	ORAI3 Ensembl NCBI GeneCards UniProt Show fit	ORAI calcium release-activated calcium modulator 3
chr12_-_8949628 Show fit	10.00	ENST00000000412.8 ENST00000543845.1 ENST00000544245.1 ENST00000536844.5	M6PR Ensembl NCBI GeneCards UniProt Show fit	mannose-6-phosphate receptor, cation dependent
chr8_-_100721583 Show fit	9.95	ENST00000610907.2 ENST00000677140.1 ENST00000677787.1 ENST00000679197.1 ENST00000519100.6	PABPC1 Ensembl NCBI GeneCards UniProt Show fit	poly(A) binding protein cytoplasmic 1
chr4_+_67558719 Show fit	9.92	ENST00000265404.7 ENST00000396225.1	STAP1 Ensembl NCBI GeneCards UniProt Show fit	signal transducing adaptor family member 1
chr17_-_5234801 Show fit	9.91	ENST00000571800.5 ENST00000574081.6 ENST00000399600.8 ENST00000574297.1	SCIMP Ensembl NCBI GeneCards UniProt Show fit	SLP adaptor and CSK interacting membrane protein
chr19_-_3786408 Show fit	9.19	ENST00000395040.6	MATK Ensembl NCBI GeneCards UniProt Show fit	megakaryocyte-associated tyrosine kinase
chr17_-_63741869 Show fit	9.17	ENST00000375840.9 ENST00000582137.6 ENST00000447001.8 ENST00000392950.9	STRADA Ensembl NCBI GeneCards UniProt Show fit	STE20 related adaptor alpha
chr17_+_77140898 Show fit	9.16	ENST00000585618.5	SEC14L1 Ensembl NCBI GeneCards UniProt Show fit	SEC14 like lipid binding 1
chr3_+_9793074 Show fit	9.05	ENST00000397261.8 ENST00000485273.1 ENST00000433034.1 ENST00000397256.5	ARPC4 Ensembl NCBI GeneCards UniProt Show fit ARPC4-TTLL3 Ensembl NCBI GeneCards UniProt Show fit	actin related protein 2/3 complex subunit 4 ARPC4-TTLL3 readthrough
chr1_+_32292067 Show fit	8.94	ENST00000373548.8 ENST00000428704.1	HDAC1 Ensembl NCBI GeneCards UniProt Show fit	histone deacetylase 1
chr5_-_39270623 Show fit	8.91	ENST00000512138.1 ENST00000646045.2	FYB1 Ensembl NCBI GeneCards UniProt Show fit	FYN binding protein 1
chr1_+_43389889 Show fit	8.87	ENST00000562955.2 ENST00000634258.3	SZT2 Ensembl NCBI GeneCards UniProt Show fit	SZT2 subunit of KICSTOR complex
chr14_-_73950393 Show fit	8.82	ENST00000651776.1	FAM161B Ensembl NCBI GeneCards UniProt Show fit	FAM161 centrosomal protein B
chr2_+_3575303 Show fit	8.66	ENST00000646909.1 ENST00000647131.1 ENST00000462576.5 ENST00000403564.5	RPS7 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S7
chr14_+_101809855 Show fit	8.57	ENST00000557714.1 ENST00000445439.7 ENST00000334743.9 ENST00000557095.5	PPP2R5C Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2 regulatory subunit B'gamma
chr2_+_3575342 Show fit	8.44	ENST00000407445.8 ENST00000406376.1	RPS7 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S7
chrX_+_123960519 Show fit	8.42	ENST00000455404.5 ENST00000218089.13	STAG2 Ensembl NCBI GeneCards UniProt Show fit	stromal antigen 2
chr6_+_391743 Show fit	8.35	ENST00000380956.9	IRF4 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 4
chr9_+_124862098 Show fit	8.28	ENST00000353214.6	ARPC5L Ensembl NCBI GeneCards UniProt Show fit	actin related protein 2/3 complex subunit 5 like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
29.6	88.8	GO:0071461	cellular response to redox state(GO:0071461)
22.1	66.3	GO:0038156	interleukin-3-mediated signaling pathway(GO:0038156)
20.8	83.3	GO:0002277	myeloid dendritic cell activation involved in immune response(GO:0002277)
19.0	75.9	GO:0045401	positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401)
16.2	48.7	GO:0002668	negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
14.7	73.6	GO:0033277	abortive mitotic cell cycle(GO:0033277)
14.0	84.3	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
13.6	54.5	GO:0045658	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
12.9	64.4	GO:0044027	hypermethylation of CpG island(GO:0044027)
12.6	37.9	GO:0002434	immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
10.7	42.9	GO:2001193	gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
9.9	9.9	GO:1904124	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
9.3	120.9	GO:2001300	lipoxin metabolic process(GO:2001300)
9.1	45.7	GO:0014738	regulation of muscle hyperplasia(GO:0014738)
9.0	45.0	GO:2001107	negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
8.5	50.9	GO:0033625	positive regulation of integrin activation(GO:0033625)
8.5	25.4	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)
8.4	41.8	GO:1900127	positive regulation of hyaluronan biosynthetic process(GO:1900127)
8.4	8.4	GO:0045402	interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
7.6	45.6	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
7.5	112.2	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
7.1	21.2	GO:0045588	regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) positive regulation of gamma-delta T cell differentiation(GO:0045588)
6.6	72.2	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
6.4	83.6	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
5.5	43.8	GO:0034128	negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
5.5	54.5	GO:0036066	protein O-linked fucosylation(GO:0036066)
5.2	31.3	GO:0000255	allantoin metabolic process(GO:0000255)
5.0	85.2	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
4.8	96.6	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
4.6	41.6	GO:0001866	NK T cell proliferation(GO:0001866)
4.5	31.5	GO:0000821	regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
4.3	13.0	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
4.3	17.2	GO:0070945	neutrophil mediated killing of gram-negative bacterium(GO:0070945)
3.6	61.1	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
3.3	68.4	GO:0032060	bleb assembly(GO:0032060)
3.0	64.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
3.0	27.4	GO:0075525	viral translational termination-reinitiation(GO:0075525)
3.0	9.1	GO:0018094	protein polyglycylation(GO:0018094)
3.0	29.5	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
2.9	17.1	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
2.8	11.2	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
2.7	18.9	GO:0035879	plasma membrane lactate transport(GO:0035879)
2.6	7.8	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
2.6	23.1	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
2.6	23.1	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
2.5	12.4	GO:0071894	histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
2.5	29.8	GO:0015939	pantothenate metabolic process(GO:0015939)
2.3	43.6	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
2.2	10.9	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
2.2	28.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
2.2	40.9	GO:0034656	nucleobase-containing small molecule catabolic process(GO:0034656)
2.2	17.2	GO:0002457	T cell antigen processing and presentation(GO:0002457)
2.1	6.4	GO:0072183	negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
2.1	14.7	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
2.0	15.8	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
2.0	23.7	GO:0001955	blood vessel maturation(GO:0001955)
1.9	35.7	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
1.8	18.0	GO:0032532	regulation of microvillus length(GO:0032532)
1.7	6.8	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)
1.7	5.0	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
1.6	165.0	GO:0050672	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.6	14.4	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
1.6	17.3	GO:0002315	marginal zone B cell differentiation(GO:0002315)
1.5	55.7	GO:0006376	mRNA splice site selection(GO:0006376)
1.5	7.5	GO:1904925	positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
1.5	8.9	GO:0021540	corpus callosum morphogenesis(GO:0021540)
1.4	28.6	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.4	16.9	GO:0015871	choline transport(GO:0015871)
1.4	12.6	GO:0015886	heme transport(GO:0015886)
1.4	8.2	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.3	132.7	GO:0071277	cellular response to calcium ion(GO:0071277)
1.3	10.6	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
1.3	5.1	GO:2000435	regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
1.3	8.9	GO:0061198	fungiform papilla formation(GO:0061198)
1.2	12.3	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
1.2	3.6	GO:0035655	interleukin-18-mediated signaling pathway(GO:0035655)
1.2	8.3	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.2	28.3	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
1.1	45.7	GO:0043984	histone H4-K16 acetylation(GO:0043984)
1.1	4.3	GO:0090135	actin filament branching(GO:0090135) protein localization to cell leading edge(GO:1902463)
1.1	36.1	GO:0045730	respiratory burst(GO:0045730)
1.1	36.9	GO:1900027	regulation of ruffle assembly(GO:1900027)
1.1	8.4	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
1.1	121.9	GO:0002819	regulation of adaptive immune response(GO:0002819)
0.9	10.0	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
0.9	7.8	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.9	23.9	GO:0010447	response to acidic pH(GO:0010447)
0.8	6.5	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.8	1.6	GO:0060023	soft palate development(GO:0060023)
0.8	5.5	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.8	13.9	GO:1900745	positive regulation of p38MAPK cascade(GO:1900745)
0.7	5.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.7	47.1	GO:0006953	acute-phase response(GO:0006953)
0.7	7.3	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.7	2.6	GO:0060022	hard palate development(GO:0060022)
0.6	5.5	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.6	23.0	GO:0006505	GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.6	85.3	GO:1990823	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.6	31.4	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.6	7.8	GO:0031642	negative regulation of myelination(GO:0031642)
0.6	26.1	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.6	1.7	GO:0050928	negative regulation of positive chemotaxis(GO:0050928)
0.5	15.3	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.5	13.2	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.5	2.1	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.5	1.5	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.5	10.0	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.5	5.0	GO:0006390	transcription from mitochondrial promoter(GO:0006390)
0.5	82.0	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.5	13.9	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.5	75.6	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.5	1.0	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.5	3.4	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.5	4.1	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.5	3.2	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.4	16.7	GO:0035329	hippo signaling(GO:0035329)
0.4	45.8	GO:0030183	B cell differentiation(GO:0030183)
0.4	3.0	GO:1901223	negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.4	1.7	GO:0060454	positive regulation of gastric acid secretion(GO:0060454)
0.4	13.4	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.4	8.3	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.4	28.1	GO:0015914	phospholipid transport(GO:0015914)
0.3	7.8	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.3	57.5	GO:0008360	regulation of cell shape(GO:0008360)
0.3	1.0	GO:0046619	optic placode formation involved in camera-type eye formation(GO:0046619) ventricular cardiac myofibril assembly(GO:0055005) aorta smooth muscle tissue morphogenesis(GO:0060414) pancreas morphogenesis(GO:0061113) regulation of forebrain neuron differentiation(GO:2000977)
0.3	4.9	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.3	3.6	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.3	3.7	GO:0030225	macrophage differentiation(GO:0030225)
0.3	8.2	GO:0015991	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.2	2.7	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.2	3.1	GO:1904871	regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.2	7.9	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.2	15.8	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.2	10.1	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.2	15.5	GO:0006611	protein export from nucleus(GO:0006611)
0.2	5.4	GO:0043551	regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2	7.9	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2	4.8	GO:0060008	Sertoli cell differentiation(GO:0060008)
0.2	21.0	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.2	4.1	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.2	2.4	GO:1901673	regulation of mitotic spindle assembly(GO:1901673)
0.2	1.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	9.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1	77.5	GO:0006954	inflammatory response(GO:0006954)
0.1	5.8	GO:0000186	activation of MAPKK activity(GO:0000186)
0.1	4.2	GO:0031440	regulation of mRNA 3'-end processing(GO:0031440)
0.1	1.6	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.1	0.9	GO:0071763	nuclear membrane organization(GO:0071763)
0.1	0.8	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1	2.1	GO:0016445	somatic diversification of immunoglobulins(GO:0016445)
0.1	1.4	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1	1.4	GO:0015671	oxygen transport(GO:0015671)
0.1	25.7	GO:0098656	anion transmembrane transport(GO:0098656)
0.1	6.6	GO:0006818	hydrogen transport(GO:0006818) proton transport(GO:0015992)
0.1	28.2	GO:0007264	small GTPase mediated signal transduction(GO:0007264)
0.0	11.2	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.0	0.6	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0	8.4	GO:0006413	translational initiation(GO:0006413)
0.0	4.4	GO:0070268	cornification(GO:0070268)
0.0	1.6	GO:0016266	O-glycan processing(GO:0016266)
0.0	1.1	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.0	2.4	GO:0007569	cell aging(GO:0007569)
0.0	1.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	8.8	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
19.3	96.6	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
17.2	86.1	GO:0019815	B cell receptor complex(GO:0019815)
6.7	73.6	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
6.4	57.3	GO:0032010	phagolysosome(GO:0032010)
6.4	44.5	GO:0070436	Grb2-EGFR complex(GO:0070436)
6.3	6.3	GO:0071159	NF-kappaB complex(GO:0071159)
5.7	45.7	GO:0072487	MSL complex(GO:0072487)
5.0	130.0	GO:0001891	phagocytic cup(GO:0001891)
4.9	43.8	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
4.1	45.0	GO:0060171	stereocilium membrane(GO:0060171)
3.3	83.6	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
3.1	40.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
2.4	9.7	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
2.0	42.7	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
1.9	26.9	GO:0048188	Set1C/COMPASS complex(GO:0048188)
1.7	5.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
1.6	21.2	GO:0031209	SCAR complex(GO:0031209)
1.4	96.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
1.3	118.3	GO:0035580	specific granule lumen(GO:0035580)
1.3	15.8	GO:0016602	CCAAT-binding factor complex(GO:0016602)
1.3	6.5	GO:0000836	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
1.3	8.9	GO:1990130	Iml1 complex(GO:1990130)
1.2	7.3	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
1.2	192.0	GO:0032587	ruffle membrane(GO:0032587)
1.1	13.0	GO:0097136	Bcl-2 family protein complex(GO:0097136)
1.1	7.6	GO:0030121	AP-1 adaptor complex(GO:0030121)
1.0	5.0	GO:0032444	activin responsive factor complex(GO:0032444)
1.0	27.4	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.9	155.5	GO:0031225	anchored component of membrane(GO:0031225)
0.9	73.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.9	8.2	GO:0042101	T cell receptor complex(GO:0042101)
0.9	17.3	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.8	5.8	GO:0000788	nuclear nucleosome(GO:0000788)
0.8	49.9	GO:0001772	immunological synapse(GO:0001772)
0.7	23.1	GO:0030686	90S preribosome(GO:0030686)
0.7	3.6	GO:0032044	DSIF complex(GO:0032044)
0.7	12.7	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.7	213.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.7	12.6	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.6	23.9	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.6	8.9	GO:0016580	Sin3 complex(GO:0016580)
0.6	18.0	GO:0032420	stereocilium(GO:0032420)
0.6	35.0	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.6	1.1	GO:0035859	Seh1-associated complex(GO:0035859) GATOR2 complex(GO:0061700)
0.6	1.7	GO:0031251	PAN complex(GO:0031251)
0.5	12.3	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.5	17.3	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.5	10.0	GO:0030904	retromer complex(GO:0030904)
0.5	5.5	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.4	69.7	GO:0098802	plasma membrane receptor complex(GO:0098802)
0.4	7.9	GO:0031932	TORC2 complex(GO:0031932)
0.3	2.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.3	51.6	GO:0016605	PML body(GO:0016605)
0.3	77.9	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3	8.3	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.3	133.3	GO:0031965	nuclear membrane(GO:0031965)
0.3	7.5	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.3	10.6	GO:0005905	clathrin-coated pit(GO:0005905)
0.3	27.0	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	1.0	GO:0002945	cyclin K-CDK13 complex(GO:0002945)
0.2	2.4	GO:0000815	ESCRT III complex(GO:0000815)
0.2	3.1	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.2	73.2	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2	62.4	GO:0030667	secretory granule membrane(GO:0030667)
0.2	134.3	GO:0000139	Golgi membrane(GO:0000139)
0.2	21.0	GO:0043197	dendritic spine(GO:0043197)
0.2	69.7	GO:0000790	nuclear chromatin(GO:0000790)
0.2	9.4	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2	249.2	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	6.8	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2	35.0	GO:0005681	spliceosomal complex(GO:0005681)
0.2	56.2	GO:0005667	transcription factor complex(GO:0005667)
0.2	20.0	GO:0016324	apical plasma membrane(GO:0016324)
0.2	1.1	GO:0097427	microtubule bundle(GO:0097427)
0.1	3.0	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.1	10.1	GO:0035578	azurophil granule lumen(GO:0035578)
0.1	10.4	GO:0005882	intermediate filament(GO:0005882)
0.1	5.0	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	6.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	4.3	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	19.3	GO:0005911	cell-cell junction(GO:0005911)
0.1	3.4	GO:0005811	lipid particle(GO:0005811)
0.1	8.9	GO:0005741	mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0	1.3	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	2.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	32.1	GO:0016021	integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
34.9	104.8	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
24.2	120.9	GO:0004464	leukotriene-C4 synthase activity(GO:0004464)
22.1	66.3	GO:0004912	interleukin-3 receptor activity(GO:0004912)
20.9	62.7	GO:0004796	thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
13.8	96.6	GO:0030369	ICAM-3 receptor activity(GO:0030369)
13.6	54.5	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
11.1	88.8	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
10.7	42.9	GO:0030107	HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
9.0	152.4	GO:0019864	IgG binding(GO:0019864)
9.0	26.9	GO:0045322	unmethylated CpG binding(GO:0045322)
7.9	15.7	GO:0019763	immunoglobulin receptor activity(GO:0019763)
7.5	29.8	GO:0017159	pantetheine hydrolase activity(GO:0017159)
7.2	57.3	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
6.3	133.3	GO:0019992	diacylglycerol binding(GO:0019992)
6.3	25.3	GO:0004609	phosphatidylserine decarboxylase activity(GO:0004609)
5.9	64.4	GO:0051525	NFAT protein binding(GO:0051525)
5.6	22.5	GO:0016019	peptidoglycan receptor activity(GO:0016019)
5.5	72.1	GO:0042608	T cell receptor binding(GO:0042608)
5.0	15.0	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
4.9	14.7	GO:0045131	pre-mRNA branch point binding(GO:0045131)
4.3	17.3	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
4.2	12.7	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
4.2	125.0	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
4.0	84.3	GO:0032036	myosin heavy chain binding(GO:0032036)
3.8	83.6	GO:0008494	translation activator activity(GO:0008494)
3.7	215.6	GO:0001784	phosphotyrosine binding(GO:0001784)
3.4	20.5	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
3.4	30.3	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
3.1	28.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
3.0	9.1	GO:0070735	protein-glycine ligase activity(GO:0070735)
2.9	17.1	GO:0035800	deubiquitinase activator activity(GO:0035800)
2.8	16.9	GO:0039552	RIG-I binding(GO:0039552)
2.7	5.4	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
2.7	29.5	GO:0019869	chloride channel inhibitor activity(GO:0019869)
2.7	131.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
2.7	21.3	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
2.7	10.6	GO:0032184	SUMO polymer binding(GO:0032184)
2.6	31.5	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
2.6	26.0	GO:1990948	ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
2.6	40.9	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
2.6	23.0	GO:0034235	GPI anchor binding(GO:0034235)
2.2	20.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
2.2	52.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
2.1	35.7	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
2.1	10.4	GO:0004920	interleukin-10 receptor activity(GO:0004920)
2.0	50.9	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.8	5.5	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
1.7	6.8	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
1.6	12.6	GO:0015232	heme transporter activity(GO:0015232)
1.6	18.9	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
1.4	66.6	GO:0036002	pre-mRNA binding(GO:0036002)
1.2	3.6	GO:0042008	interleukin-18 receptor activity(GO:0042008)
1.2	44.9	GO:0071889	14-3-3 protein binding(GO:0071889)
1.1	7.8	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.1	10.0	GO:0015279	store-operated calcium channel activity(GO:0015279)
1.1	13.0	GO:0051434	protein channel activity(GO:0015266) BH3 domain binding(GO:0051434)
1.0	5.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
1.0	3.0	GO:0055100	adiponectin binding(GO:0055100)
0.9	48.5	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.9	3.4	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.8	10.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.8	4.1	GO:0004883	glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.8	10.6	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.8	14.6	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.8	47.1	GO:0005044	scavenger receptor activity(GO:0005044)
0.7	16.9	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.7	7.8	GO:0004875	complement receptor activity(GO:0004875)
0.6	20.1	GO:0003785	actin monomer binding(GO:0003785)
0.6	38.9	GO:0015026	coreceptor activity(GO:0015026)
0.6	5.0	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.6	4.2	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.6	8.9	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.6	8.3	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.6	6.3	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.6	45.7	GO:0035064	methylated histone binding(GO:0035064)
0.6	10.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.6	5.0	GO:0043139	5'-3' DNA helicase activity(GO:0043139)
0.6	5.5	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5	4.3	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.5	4.3	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.5	37.2	GO:0003743	translation initiation factor activity(GO:0003743)
0.5	16.0	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.5	7.5	GO:0019789	SUMO transferase activity(GO:0019789)
0.5	26.6	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.5	7.3	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.4	3.1	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.4	10.6	GO:0032452	histone demethylase activity(GO:0032452)
0.4	80.9	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.4	13.9	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4	1.7	GO:0001626	nociceptin receptor activity(GO:0001626)
0.4	2.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4	27.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3	10.0	GO:0015149	hexose transmembrane transporter activity(GO:0015149)
0.3	1.0	GO:0050692	DBD domain binding(GO:0050692)
0.3	12.3	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.3	23.9	GO:0030295	protein kinase activator activity(GO:0030295)
0.3	35.7	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.3	105.1	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3	104.1	GO:0003924	GTPase activity(GO:0003924)
0.3	6.1	GO:0044769	hydrogen-exporting ATPase activity(GO:0036442) ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3	1.3	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.3	7.2	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.2	12.9	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2	4.2	GO:0046965	retinoid X receptor binding(GO:0046965)
0.2	13.1	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.2	47.1	GO:0051015	actin filament binding(GO:0051015)
0.2	14.9	GO:0097110	scaffold protein binding(GO:0097110)
0.2	1.1	GO:0070728	leucine binding(GO:0070728)
0.2	17.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.2	30.6	GO:0004713	protein tyrosine kinase activity(GO:0004713)
0.2	9.4	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2	9.9	GO:0017080	sodium channel regulator activity(GO:0017080)
0.2	8.9	GO:0019843	rRNA binding(GO:0019843)
0.2	17.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	3.8	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	2.1	GO:0042288	MHC class I protein binding(GO:0042288)
0.1	39.5	GO:0030246	carbohydrate binding(GO:0030246)
0.1	5.8	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1	2.1	GO:0001055	RNA polymerase II activity(GO:0001055)
0.1	6.0	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1	19.5	GO:0003823	antigen binding(GO:0003823)
0.1	1.7	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.1	1.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	3.0	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	86.8	GO:0004872	receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.1	0.6	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0	13.4	GO:0005096	GTPase activator activity(GO:0005096)
0.0	0.3	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.9	GO:0005521	lamin binding(GO:0005521)
0.0	1.4	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	1.1	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.8	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	2.9	GO:0004871	signal transducer activity(GO:0004871)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.6	140.6	PID IL5 PATHWAY	IL5-mediated signaling events
4.0	198.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
3.7	110.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
3.6	190.7	PID EPO PATHWAY	EPO signaling pathway
3.0	133.3	PID RAS PATHWAY	Regulation of Ras family activation
2.7	123.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
1.9	158.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
1.9	122.8	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
1.5	43.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.5	112.3	PID RHOA REG PATHWAY	Regulation of RhoA activity
1.1	55.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
1.1	72.7	PID IL4 2PATHWAY	IL4-mediated signaling events
0.9	64.4	PID RAC1 PATHWAY	RAC1 signaling pathway
0.9	37.1	PID BCR 5PATHWAY	BCR signaling pathway
0.9	35.3	PID IL12 2PATHWAY	IL12-mediated signaling events
0.8	6.5	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.6	10.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.6	21.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.6	12.6	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5	19.9	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.5	6.8	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.4	7.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4	24.1	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	13.0	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.3	109.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	5.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.2	5.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.2	11.2	PID LKB1 PATHWAY	LKB1 signaling events
0.2	15.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	8.4	PID PLK1 PATHWAY	PLK1 signaling events
0.1	7.1	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	18.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	1.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	2.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	3.3	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	2.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	2.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	1.2	PID CDC42 PATHWAY	CDC42 signaling events
0.0	1.3	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.3	31.4	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
4.9	133.4	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
4.9	108.5	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
3.4	43.8	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
3.3	129.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
3.1	103.9	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
3.0	48.7	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
3.0	42.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
2.7	65.7	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
2.6	290.7	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
2.3	83.6	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
1.9	72.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
1.9	35.7	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
1.7	23.6	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.6	14.6	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
1.6	28.7	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
1.6	120.0	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.5	15.0	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
1.4	115.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.3	23.9	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
1.3	25.9	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.2	85.9	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
1.1	29.5	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.0	121.4	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
1.0	62.7	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.8	27.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.7	120.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.7	9.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.5	6.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.5	13.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.5	8.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.4	10.5	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.4	26.9	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4	11.2	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.3	14.0	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3	29.3	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.3	10.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	14.6	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.2	4.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.2	8.4	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	4.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	8.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.6	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1	3.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	5.5	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	2.7	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.1	10.3	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.1	3.1	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	2.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	1.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	11.5	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.1	1.1	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.1	3.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	6.3	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	4.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	1.6	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	2.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	1.7	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	0.3	REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	Genes involved in Activation of Kainate Receptors upon glutamate binding

Results for SPIB

Z-value: 3.23

Motif logo

Transcription factors associated with SPIB

Activity-expression correlation:

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: