ISMARA results: STAT4

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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for STAT4

Z-value: 5.43

Motif logo

Transcription factors associated with STAT4

Gene Symbol	Gene ID	Gene Info
STAT4 Ensembl NCBI GeneCards UniProt	ENSG00000138378.19	STAT4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT4	hg38_v1_chr2_-_191150971_191151017, hg38_v1_chr2_-_191151568_191151596	0.35	8.8e-08	Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr19_-_34677157 Show fit	13.71	ENST00000601241.6	SCGB2B2 Ensembl NCBI GeneCards UniProt Show fit	secretoglobin family 2B member 2
chr8_-_27611325 Show fit	12.35	ENST00000523500.5	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr10_+_104269163 Show fit	11.14	ENST00000338595.7	GSTO2 Ensembl NCBI GeneCards UniProt Show fit	glutathione S-transferase omega 2
chr5_-_140633690 Show fit	10.90	ENST00000512545.1 ENST00000401743.6	CD14 Ensembl NCBI GeneCards UniProt Show fit	CD14 molecule
chr2_+_68734861 Show fit	10.86	ENST00000467265.5	ARHGAP25 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 25
chr5_-_140633167 Show fit	10.82	ENST00000302014.11	CD14 Ensembl NCBI GeneCards UniProt Show fit	CD14 molecule
chr4_+_157220654 Show fit	10.55	ENST00000393815.6	GRIA2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr4_+_157220691 Show fit	10.38	ENST00000509417.5 ENST00000645636.1 ENST00000296526.12 ENST00000264426.14	GRIA2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr1_+_232950580 Show fit	10.17	ENST00000366628.10 ENST00000366627.4	NTPCR Ensembl NCBI GeneCards UniProt Show fit	nucleoside-triphosphatase, cancer-related
chr14_-_21022817 Show fit	9.94	ENST00000554104.5	NDRG2 Ensembl NCBI GeneCards UniProt Show fit	NDRG family member 2
chr8_-_27611424 Show fit	9.06	ENST00000405140.7	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr14_-_21022494 Show fit	8.96	ENST00000449431.6	NDRG2 Ensembl NCBI GeneCards UniProt Show fit	NDRG family member 2
chr1_-_230745574 Show fit	8.65	ENST00000681269.1	AGT Ensembl NCBI GeneCards UniProt Show fit	angiotensinogen
chr14_-_21022095 Show fit	8.54	ENST00000635386.1	NDRG2 Ensembl NCBI GeneCards UniProt Show fit	NDRG family member 2
chr14_-_20802402 Show fit	8.26	ENST00000412779.2	RNASE1 Ensembl NCBI GeneCards UniProt Show fit	ribonuclease A family member 1, pancreatic
chr17_-_35880350 Show fit	8.20	ENST00000605140.6 ENST00000651122.1 ENST00000603197.6	CCL5 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 5
chr14_-_21022432 Show fit	8.19	ENST00000557633.5	NDRG2 Ensembl NCBI GeneCards UniProt Show fit	NDRG family member 2
chrX_-_66033664 Show fit	8.12	ENST00000427538.5	VSIG4 Ensembl NCBI GeneCards UniProt Show fit	V-set and immunoglobulin domain containing 4
chr14_-_21022258 Show fit	8.03	ENST00000556366.5	NDRG2 Ensembl NCBI GeneCards UniProt Show fit	NDRG family member 2
chr16_+_58249910 Show fit	7.95	ENST00000219299.8 ENST00000443128.6 ENST00000616795.1	CCDC113 Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 113
chr3_+_122577596 Show fit	6.94	ENST00000483793.5 ENST00000464300.7	PARP15 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 15
chr3_+_15427551 Show fit	6.80	ENST00000396842.7	EAF1 Ensembl NCBI GeneCards UniProt Show fit	ELL associated factor 1
chr3_-_15427497 Show fit	6.77	ENST00000443029.5 ENST00000383789.9 ENST00000450816.6 ENST00000383790.8	METTL6 Ensembl NCBI GeneCards UniProt Show fit	methyltransferase like 6
chr5_+_36606355 Show fit	6.41	ENST00000681909.1 ENST00000513903.5 ENST00000681795.1 ENST00000680125.1 ENST00000612708.5 ENST00000680232.1 ENST00000681776.1 ENST00000681926.1 ENST00000679958.1 ENST00000265113.9 ENST00000504121.5 ENST00000512374.1 ENST00000613445.5 ENST00000679983.1	SLC1A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 1 member 3
chr19_+_39391323 Show fit	6.24	ENST00000615911.4 ENST00000315588.11 ENST00000594368.5 ENST00000596297.1	MED29 Ensembl NCBI GeneCards UniProt Show fit	mediator complex subunit 29
chr7_-_150341615 Show fit	5.99	ENST00000223271.8 ENST00000466675.5 ENST00000482669.1 ENST00000467793.5	RARRES2 Ensembl NCBI GeneCards UniProt Show fit	retinoic acid receptor responder 2
chr1_+_17580474 Show fit	5.96	ENST00000375415.5	ARHGEF10L Ensembl NCBI GeneCards UniProt Show fit	Rho guanine nucleotide exchange factor 10 like
chr5_+_40909490 Show fit	5.79	ENST00000313164.10	C7 Ensembl NCBI GeneCards UniProt Show fit	complement C7
chr12_+_57745017 Show fit	5.51	ENST00000547992.5 ENST00000552816.5 ENST00000257910.8 ENST00000547472.5	TSPAN31 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 31
chr6_+_133889105 Show fit	5.42	ENST00000367882.5	TCF21 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 21
chr16_-_20327426 Show fit	5.40	ENST00000575582.5 ENST00000341642.9 ENST00000381362.8 ENST00000572347.5 ENST00000572478.5 ENST00000302555.10	GP2 Ensembl NCBI GeneCards UniProt Show fit	glycoprotein 2
chr8_-_109648825 Show fit	5.39	ENST00000533895.5 ENST00000446070.6 ENST00000528331.5 ENST00000526302.5 ENST00000408908.6 ENST00000433638.1 ENST00000524720.5	SYBU Ensembl NCBI GeneCards UniProt Show fit	syntabulin
chr1_+_15236509 Show fit	5.20	ENST00000683790.1	FHAD1 Ensembl NCBI GeneCards UniProt Show fit	forkhead associated phosphopeptide binding domain 1
chr19_+_34677723 Show fit	5.08	ENST00000505365.2	ZNF302 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 302
chr5_-_39274515 Show fit	5.07	ENST00000510188.1	FYB1 Ensembl NCBI GeneCards UniProt Show fit	FYN binding protein 1
chr1_-_161309961 Show fit	5.07	ENST00000533357.5 ENST00000672602.2 ENST00000526189.3	MPZ Ensembl NCBI GeneCards UniProt Show fit	myelin protein zero
chrX_+_108044967 Show fit	5.00	ENST00000415430.7	VSIG1 Ensembl NCBI GeneCards UniProt Show fit	V-set and immunoglobulin domain containing 1
chr19_+_34677639 Show fit	4.94	ENST00000627982.2 ENST00000613363.4 ENST00000502743.5 ENST00000509528.5 ENST00000506901.5 ENST00000457781.6 ENST00000505163.5 ENST00000505242.6 ENST00000423823.6 ENST00000507959.5 ENST00000446502.6	ZNF302 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 302
chr3_-_50611767 Show fit	4.91	ENST00000443053.6 ENST00000348721.4	CISH Ensembl NCBI GeneCards UniProt Show fit	cytokine inducible SH2 containing protein
chr1_+_116754422 Show fit	4.79	ENST00000369478.4 ENST00000369477.1	CD2 Ensembl NCBI GeneCards UniProt Show fit	CD2 molecule
chr2_+_68734773 Show fit	4.70	ENST00000409202.8	ARHGAP25 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 25
chr7_-_83649097 Show fit	4.63	ENST00000643230.2	SEMA3E Ensembl NCBI GeneCards UniProt Show fit	semaphorin 3E
chr11_-_31804067 Show fit	4.60	ENST00000639548.1 ENST00000640125.1 ENST00000481563.6 ENST00000639079.1 ENST00000638762.1 ENST00000638346.1	PAX6 Ensembl NCBI GeneCards UniProt Show fit	paired box 6
chr11_-_120128831 Show fit	4.56	ENST00000529044.5	TRIM29 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 29
chr19_+_56595279 Show fit	4.41	ENST00000328070.10 ENST00000599599.7 ENST00000650950.1	ZNF71 Ensembl NCBI GeneCards UniProt Show fit ZIM2-AS1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 71 ZIM2 antisense RNA 1
chr6_-_46921926 Show fit	4.28	ENST00000283296.12	ADGRF5 Ensembl NCBI GeneCards UniProt Show fit	adhesion G protein-coupled receptor F5
chr16_+_85899121 Show fit	4.28	ENST00000268638.10 ENST00000565552.1	IRF8 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 8
chr6_-_166167832 Show fit	4.27	ENST00000366876.7	TBXT Ensembl NCBI GeneCards UniProt Show fit	T-box transcription factor T
chr5_+_55160161 Show fit	4.24	ENST00000296734.6 ENST00000515370.1 ENST00000503787.6	GPX8 Ensembl NCBI GeneCards UniProt Show fit	glutathione peroxidase 8 (putative)
chr5_+_140882116 Show fit	4.17	ENST00000289272.3 ENST00000409494.5 ENST00000617769.1	PCDHA13 Ensembl NCBI GeneCards UniProt Show fit	protocadherin alpha 13
chr15_+_63048576 Show fit	4.16	ENST00000559281.6	TPM1 Ensembl NCBI GeneCards UniProt Show fit	tropomyosin 1
chr11_-_118176576 Show fit	4.03	ENST00000278947.6	SCN2B Ensembl NCBI GeneCards UniProt Show fit	sodium voltage-gated channel beta subunit 2
chrX_+_108045050 Show fit	4.00	ENST00000458383.1 ENST00000217957.10	VSIG1 Ensembl NCBI GeneCards UniProt Show fit	V-set and immunoglobulin domain containing 1
chrX_+_139530730 Show fit	4.00	ENST00000218099.7	F9 Ensembl NCBI GeneCards UniProt Show fit	coagulation factor IX
chr5_-_151686908 Show fit	3.83	ENST00000231061.9	SPARC Ensembl NCBI GeneCards UniProt Show fit	secreted protein acidic and cysteine rich
chr19_-_58573280 Show fit	3.74	ENST00000594234.5 ENST00000596039.1 ENST00000215057.7	MZF1 Ensembl NCBI GeneCards UniProt Show fit	myeloid zinc finger 1
chr11_+_64924673 Show fit	3.64	ENST00000164133.7 ENST00000532850.1	PPP2R5B Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2 regulatory subunit B'beta
chr19_+_44113385 Show fit	3.59	ENST00000262894.11 ENST00000588926.5 ENST00000592780.5	ZNF225 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 225
chr10_+_17752185 Show fit	3.56	ENST00000377495.2	TMEM236 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 236
chr6_+_101181254 Show fit	3.50	ENST00000682090.1 ENST00000421544.6	GRIK2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor kainate type subunit 2
chr19_+_44094380 Show fit	3.43	ENST00000336976.10	ZNF224 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 224
chr2_+_113127588 Show fit	3.43	ENST00000409930.4	IL1RN Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor antagonist
chr3_-_52830664 Show fit	3.36	ENST00000266041.9 ENST00000406595.5 ENST00000485816.5	ITIH4 Ensembl NCBI GeneCards UniProt Show fit	inter-alpha-trypsin inhibitor heavy chain 4
chr14_+_24161257 Show fit	3.30	ENST00000396864.8 ENST00000557894.5 ENST00000559284.5 ENST00000560275.5	IRF9 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 9
chr12_+_53050179 Show fit	3.26	ENST00000546602.5 ENST00000552570.5 ENST00000549700.5	TNS2 Ensembl NCBI GeneCards UniProt Show fit	tensin 2
chr7_-_83162899 Show fit	3.24	ENST00000423517.6	PCLO Ensembl NCBI GeneCards UniProt Show fit	piccolo presynaptic cytomatrix protein
chr6_+_167111789 Show fit	3.23	ENST00000400926.5	CCR6 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine receptor 6
chr1_+_155173787 Show fit	3.11	ENST00000392451.6 ENST00000545012.5 ENST00000334634.9 ENST00000368385.8 ENST00000543729.5 ENST00000368383.7 ENST00000368382.5	TRIM46 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 46
chr1_+_50105666 Show fit	3.07	ENST00000651347.1	ELAVL4 Ensembl NCBI GeneCards UniProt Show fit	ELAV like RNA binding protein 4
chr1_+_121087343 Show fit	3.03	ENST00000616817.4 ENST00000623603.3 ENST00000369384.9 ENST00000369383.8 ENST00000369178.5	FCGR1B Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor Ib
chr13_-_45341086 Show fit	3.01	ENST00000309246.9 ENST00000379060.8 ENST00000379055.5 ENST00000527226.2 ENST00000530705.6 ENST00000379056.5 ENST00000616577.4	TPT1 Ensembl NCBI GeneCards UniProt Show fit	tumor protein, translationally-controlled 1
chr17_-_51120855 Show fit	2.94	ENST00000618113.4 ENST00000357122.8 ENST00000262013.12	SPAG9 Ensembl NCBI GeneCards UniProt Show fit	sperm associated antigen 9
chr11_+_73308237 Show fit	2.86	ENST00000263674.4	ARHGEF17 Ensembl NCBI GeneCards UniProt Show fit	Rho guanine nucleotide exchange factor 17
chr3_+_156120572 Show fit	2.83	ENST00000389636.9 ENST00000490337.6	KCNAB1 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr10_-_102419693 Show fit	2.80	ENST00000611678.4	PSD Ensembl NCBI GeneCards UniProt Show fit	pleckstrin and Sec7 domain containing
chr13_-_26221703 Show fit	2.79	ENST00000381570.7 ENST00000346166.7	RNF6 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 6
chr17_-_60526167 Show fit	2.74	ENST00000083182.8	APPBP2 Ensembl NCBI GeneCards UniProt Show fit	amyloid beta precursor protein binding protein 2
chr11_+_118304881 Show fit	2.73	ENST00000528600.1	CD3E Ensembl NCBI GeneCards UniProt Show fit	CD3e molecule
chr2_-_166375901 Show fit	2.69	ENST00000303354.11 ENST00000645907.1 ENST00000642356.2 ENST00000452182.2	SCN9A Ensembl NCBI GeneCards UniProt Show fit	sodium voltage-gated channel alpha subunit 9
chr22_+_35648438 Show fit	2.68	ENST00000409652.5	APOL6 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L6
chr5_-_161546671 Show fit	2.67	ENST00000517547.5	GABRB2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit beta2
chr11_-_118565992 Show fit	2.64	ENST00000264020.6	IFT46 Ensembl NCBI GeneCards UniProt Show fit	intraflagellar transport 46
chr5_+_141343818 Show fit	2.63	ENST00000619750.1 ENST00000253812.8	PCDHGA3 Ensembl NCBI GeneCards UniProt Show fit	protocadherin gamma subfamily A, 3
chr10_-_114684457 Show fit	2.58	ENST00000392955.7	ABLIM1 Ensembl NCBI GeneCards UniProt Show fit	actin binding LIM protein 1
chr3_+_171843337 Show fit	2.55	ENST00000334567.9 ENST00000619900.4 ENST00000450693.1	TMEM212 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 212
chr6_+_30888672 Show fit	2.51	ENST00000446312.5	DDR1 Ensembl NCBI GeneCards UniProt Show fit	discoidin domain receptor tyrosine kinase 1
chr1_+_50106265 Show fit	2.51	ENST00000357083.8	ELAVL4 Ensembl NCBI GeneCards UniProt Show fit	ELAV like RNA binding protein 4
chr5_-_16508812 Show fit	2.45	ENST00000683414.1	RETREG1 Ensembl NCBI GeneCards UniProt Show fit	reticulophagy regulator 1
chr1_+_149782671 Show fit	2.43	ENST00000444948.5 ENST00000369168.5	FCGR1A Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor Ia
chr5_-_16508951 Show fit	2.39	ENST00000682628.1	RETREG1 Ensembl NCBI GeneCards UniProt Show fit	reticulophagy regulator 1
chr5_-_16508858 Show fit	2.39	ENST00000684456.1	RETREG1 Ensembl NCBI GeneCards UniProt Show fit	reticulophagy regulator 1
chr1_+_9239835 Show fit	2.30	ENST00000602477.1	H6PD Ensembl NCBI GeneCards UniProt Show fit	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
chr12_+_55931148 Show fit	2.29	ENST00000549629.5 ENST00000555218.5 ENST00000331886.10	DGKA Ensembl NCBI GeneCards UniProt Show fit	diacylglycerol kinase alpha
chr17_+_34356472 Show fit	2.26	ENST00000225844.7	CCL13 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 13
chr21_+_34364003 Show fit	2.26	ENST00000290310.4	KCNE2 Ensembl NCBI GeneCards UniProt Show fit	potassium voltage-gated channel subfamily E regulatory subunit 2
chr20_+_8132138 Show fit	2.21	ENST00000378641.7 ENST00000338037.11 ENST00000629992.2	PLCB1 Ensembl NCBI GeneCards UniProt Show fit	phospholipase C beta 1
chr5_-_122078249 Show fit	2.18	ENST00000231004.5	LOX Ensembl NCBI GeneCards UniProt Show fit	lysyl oxidase
chr5_-_22853320 Show fit	2.15	ENST00000504376.6 ENST00000382254.6	CDH12 Ensembl NCBI GeneCards UniProt Show fit	cadherin 12
chr5_-_16508990 Show fit	2.10	ENST00000399793.6	RETREG1 Ensembl NCBI GeneCards UniProt Show fit	reticulophagy regulator 1
chr2_-_166375969 Show fit	2.10	ENST00000454569.6 ENST00000409672.5	SCN9A Ensembl NCBI GeneCards UniProt Show fit	sodium voltage-gated channel alpha subunit 9
chr15_+_63048436 Show fit	2.08	ENST00000334895.10 ENST00000404484.9 ENST00000558910.3 ENST00000317516.12	TPM1 Ensembl NCBI GeneCards UniProt Show fit	tropomyosin 1
chr7_+_117480011 Show fit	2.07	ENST00000649406.1 ENST00000648260.1 ENST00000003084.11	CFTR Ensembl NCBI GeneCards UniProt Show fit	CF transmembrane conductance regulator
chr20_+_43507668 Show fit	2.03	ENST00000434666.5 ENST00000649084.1 ENST00000418998.7 ENST00000427442.8 ENST00000649917.1	L3MBTL1 Ensembl NCBI GeneCards UniProt Show fit	L3MBTL histone methyl-lysine binding protein 1
chr10_-_102419934 Show fit	2.02	ENST00000406432.5	PSD Ensembl NCBI GeneCards UniProt Show fit	pleckstrin and Sec7 domain containing
chr5_-_65481907 Show fit	1.99	ENST00000381055.8	ADAMTS6 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase with thrombospondin type 1 motif 6
chr6_+_25754699 Show fit	1.95	ENST00000439485.6 ENST00000377905.9	SLC17A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 17 member 4
chr2_-_159616442 Show fit	1.94	ENST00000541068.6 ENST00000392783.7 ENST00000392782.5	BAZ2B Ensembl NCBI GeneCards UniProt Show fit	bromodomain adjacent to zinc finger domain 2B
chr5_-_161546708 Show fit	1.94	ENST00000393959.6	GABRB2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit beta2
chr22_-_31140494 Show fit	1.91	ENST00000215885.4	PLA2G3 Ensembl NCBI GeneCards UniProt Show fit	phospholipase A2 group III
chr19_+_34734155 Show fit	1.91	ENST00000599244.5 ENST00000392232.7 ENST00000492450.3 ENST00000595708.5 ENST00000593781.5	ZNF181 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 181
chr6_-_32184287 Show fit	1.90	ENST00000375069.7 ENST00000375070.7 ENST00000438221.6 ENST00000620802.4 ENST00000538695.2	AGER Ensembl NCBI GeneCards UniProt Show fit	advanced glycosylation end-product specific receptor
chr7_-_95596507 Show fit	1.89	ENST00000005178.6	PDK4 Ensembl NCBI GeneCards UniProt Show fit	pyruvate dehydrogenase kinase 4
chr9_+_114611206 Show fit	1.81	ENST00000374049.4 ENST00000288502.9	TMEM268 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 268
chr19_+_39997031 Show fit	1.78	ENST00000599504.5 ENST00000596894.5 ENST00000601138.5 ENST00000347077.9 ENST00000600094.5	ZNF546 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 546
chr19_+_35282520 Show fit	1.77	ENST00000222304.5	HAMP Ensembl NCBI GeneCards UniProt Show fit	hepcidin antimicrobial peptide
chr9_-_114074969 Show fit	1.73	ENST00000466610.6	AMBP Ensembl NCBI GeneCards UniProt Show fit	alpha-1-microglobulin/bikunin precursor
chr19_+_10086305 Show fit	1.73	ENST00000253110.16 ENST00000591813.5	SHFL Ensembl NCBI GeneCards UniProt Show fit	shiftless antiviral inhibitor of ribosomal frameshifting
chr19_+_10086787 Show fit	1.72	ENST00000590378.5 ENST00000397881.7	SHFL Ensembl NCBI GeneCards UniProt Show fit	shiftless antiviral inhibitor of ribosomal frameshifting
chr14_-_20413420 Show fit	1.69	ENST00000556935.5 ENST00000556549.1 ENST00000262715.10	TEP1 Ensembl NCBI GeneCards UniProt Show fit	telomerase associated protein 1
chr2_-_162071183 Show fit	1.69	ENST00000678668.1	DPP4 Ensembl NCBI GeneCards UniProt Show fit	dipeptidyl peptidase 4
chr3_+_108296489 Show fit	1.69	ENST00000619531.4	HHLA2 Ensembl NCBI GeneCards UniProt Show fit	HERV-H LTR-associating 2
chr2_+_102187015 Show fit	1.68	ENST00000441515.3 ENST00000264257.7	IL1RL2 Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor like 2
chr14_-_24634266 Show fit	1.68	ENST00000382540.5	GZMB Ensembl NCBI GeneCards UniProt Show fit	granzyme B
chr12_+_20695323 Show fit	1.67	ENST00000266509.7	SLCO1C1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier organic anion transporter family member 1C1
chrX_+_136487940 Show fit	1.65	ENST00000370648.4	BRS3 Ensembl NCBI GeneCards UniProt Show fit	bombesin receptor subtype 3
chr14_+_96256194 Show fit	1.63	ENST00000216629.11 ENST00000553356.1	BDKRB1 Ensembl NCBI GeneCards UniProt Show fit	bradykinin receptor B1
chr11_+_118304721 Show fit	1.57	ENST00000361763.9	CD3E Ensembl NCBI GeneCards UniProt Show fit	CD3e molecule
chr19_-_50025936 Show fit	1.57	ENST00000596445.5 ENST00000599538.5	VRK3 Ensembl NCBI GeneCards UniProt Show fit	VRK serine/threonine kinase 3
chr12_+_20695553 Show fit	1.54	ENST00000545102.1	SLCO1C1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier organic anion transporter family member 1C1
chr5_+_137867852 Show fit	1.53	ENST00000421631.6 ENST00000239926.9	MYOT Ensembl NCBI GeneCards UniProt Show fit	myotilin
chr14_-_24634160 Show fit	1.52	ENST00000616551.1 ENST00000382542.5 ENST00000216341.9 ENST00000526004.1 ENST00000415355.7	GZMB Ensembl NCBI GeneCards UniProt Show fit	granzyme B
chr12_-_9999176 Show fit	1.51	ENST00000298527.10 ENST00000348658.4	CLEC1B Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain family 1 member B
chr19_+_50025714 Show fit	1.51	ENST00000598809.5 ENST00000595661.5 ENST00000391821.6	ZNF473 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 473
chr6_-_49744378 Show fit	1.50	ENST00000371159.8 ENST00000263045.9	CRISP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine rich secretory protein 3
chr6_+_36676455 Show fit	1.49	ENST00000615513.4	CDKN1A Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase inhibitor 1A
chr2_+_209580024 Show fit	1.49	ENST00000392194.5	MAP2 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 2
chr10_+_101031223 Show fit	1.47	ENST00000393459.5 ENST00000224807.9	SFXN3 Ensembl NCBI GeneCards UniProt Show fit	sideroflexin 3
chr10_-_114684612 Show fit	1.44	ENST00000533213.6 ENST00000369252.8	ABLIM1 Ensembl NCBI GeneCards UniProt Show fit	actin binding LIM protein 1
chrX_-_155334580 Show fit	1.34	ENST00000369449.7 ENST00000321926.4	CLIC2 Ensembl NCBI GeneCards UniProt Show fit	chloride intracellular channel 2
chr5_-_161546970 Show fit	1.34	ENST00000675303.1	GABRB2 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit beta2
chrX_-_138711663 Show fit	1.33	ENST00000315930.11	FGF13 Ensembl NCBI GeneCards UniProt Show fit	fibroblast growth factor 13
chr3_+_111542178 Show fit	1.33	ENST00000283285.10 ENST00000352690.9	CD96 Ensembl NCBI GeneCards UniProt Show fit	CD96 molecule
chr5_+_137867868 Show fit	1.29	ENST00000515645.1	MYOT Ensembl NCBI GeneCards UniProt Show fit	myotilin
chr11_-_85627268 Show fit	1.27	ENST00000650630.1	DLG2 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 2
chr9_-_113401249 Show fit	1.27	ENST00000409155.8 ENST00000448137.5	ALAD Ensembl NCBI GeneCards UniProt Show fit	aminolevulinate dehydratase
chr14_+_69191760 Show fit	1.24	ENST00000409949.5 ENST00000312994.9 ENST00000409242.5 ENST00000413191.1	EXD2 Ensembl NCBI GeneCards UniProt Show fit	exonuclease 3'-5' domain containing 2
chr6_-_25874212 Show fit	1.21	ENST00000361703.10 ENST00000397060.8	SLC17A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 17 member 3
chr4_-_76036060 Show fit	1.21	ENST00000306621.8	CXCL11 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 11
chr19_+_50025989 Show fit	1.20	ENST00000445728.7 ENST00000270617.8 ENST00000601364.5	ZNF473 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 473
chr15_-_65792283 Show fit	1.19	ENST00000443035.8 ENST00000564674.5	DENND4A Ensembl NCBI GeneCards UniProt Show fit	DENN domain containing 4A
chrX_-_140784366 Show fit	1.15	ENST00000674533.1	CDR1 Ensembl NCBI GeneCards UniProt Show fit	cerebellar degeneration related protein 1
chr3_-_184017863 Show fit	1.15	ENST00000427120.6 ENST00000334444.11 ENST00000392579.6 ENST00000382494.6 ENST00000265586.10 ENST00000446941.2	ABCC5 Ensembl NCBI GeneCards UniProt Show fit	ATP binding cassette subfamily C member 5
chr17_+_2056073 Show fit	1.12	ENST00000576444.1 ENST00000322941.3	HIC1 Ensembl NCBI GeneCards UniProt Show fit	HIC ZBTB transcriptional repressor 1
chr11_+_124115404 Show fit	1.08	ENST00000361352.9 ENST00000449321.5 ENST00000392748.5 ENST00000392744.4 ENST00000456829.7	VWA5A Ensembl NCBI GeneCards UniProt Show fit	von Willebrand factor A domain containing 5A
chr5_-_128339191 Show fit	1.07	ENST00000507835.5	FBN2 Ensembl NCBI GeneCards UniProt Show fit	fibrillin 2
chr7_-_83162857 Show fit	1.07	ENST00000333891.14	PCLO Ensembl NCBI GeneCards UniProt Show fit	piccolo presynaptic cytomatrix protein
chr18_-_27990256 Show fit	0.99	ENST00000675173.1	CDH2 Ensembl NCBI GeneCards UniProt Show fit	cadherin 2
chr6_+_36676489 Show fit	0.96	ENST00000448526.6	CDKN1A Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase inhibitor 1A
chr7_-_116030735 Show fit	0.90	ENST00000393485.5	TFEC Ensembl NCBI GeneCards UniProt Show fit	transcription factor EC
chr11_-_120138104 Show fit	0.89	ENST00000341846.10	TRIM29 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 29
chr7_+_117480052 Show fit	0.81	ENST00000426809.5 ENST00000649781.1	CFTR Ensembl NCBI GeneCards UniProt Show fit	CF transmembrane conductance regulator
chr15_+_63048658 Show fit	0.80	ENST00000560615.5 ENST00000651577.1	TPM1 Ensembl NCBI GeneCards UniProt Show fit	tropomyosin 1
chr19_+_44165067 Show fit	0.80	ENST00000590578.5 ENST00000589160.5 ENST00000586286.5 ENST00000337433.10 ENST00000585560.5 ENST00000586914.5 ENST00000588883.5 ENST00000413984.6 ENST00000588742.5 ENST00000300823.10 ENST00000585678.5 ENST00000586203.5 ENST00000590467.5 ENST00000588795.5 ENST00000588127.5	ZNF226 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 226
chr2_+_233917371 Show fit	0.78	ENST00000324695.9 ENST00000433712.6	TRPM8 Ensembl NCBI GeneCards UniProt Show fit	transient receptor potential cation channel subfamily M member 8
chr2_-_79159747 Show fit	0.78	ENST00000409839.7 ENST00000305165.3 ENST00000393878.5 ENST00000490901.2	REG3A Ensembl NCBI GeneCards UniProt Show fit	regenerating family member 3 alpha
chr6_-_56851888 Show fit	0.76	ENST00000312431.10 ENST00000520645.5	DST Ensembl NCBI GeneCards UniProt Show fit	dystonin
chr6_+_31114793 Show fit	0.72	ENST00000259881.10	PSORS1C1 Ensembl NCBI GeneCards UniProt Show fit	psoriasis susceptibility 1 candidate 1
chr19_-_51372640 Show fit	0.69	ENST00000600427.5 ENST00000221978.10	NKG7 Ensembl NCBI GeneCards UniProt Show fit	natural killer cell granule protein 7
chr1_+_161663147 Show fit	0.68	ENST00000236937.13 ENST00000367961.8 ENST00000358671.9	FCGR2B Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor IIb
chr20_+_19886506 Show fit	0.68	ENST00000648440.1	RIN2 Ensembl NCBI GeneCards UniProt Show fit	Ras and Rab interactor 2
chr22_+_24155797 Show fit	0.63	ENST00000337989.11	CABIN1 Ensembl NCBI GeneCards UniProt Show fit	calcineurin binding protein 1
chr6_-_32853813 Show fit	0.63	ENST00000643049.2	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP binding cassette subfamily B member
chr3_-_138132381 Show fit	0.57	ENST00000236709.4	A4GNT Ensembl NCBI GeneCards UniProt Show fit	alpha-1,4-N-acetylglucosaminyltransferase
chr17_+_42980547 Show fit	0.54	ENST00000361677.5 ENST00000589705.1	RUNDC1 Ensembl NCBI GeneCards UniProt Show fit	RUN domain containing 1
chr11_+_73292755 Show fit	0.54	ENST00000680955.1 ENST00000538328.2	P2RY6 Ensembl NCBI GeneCards UniProt Show fit	pyrimidinergic receptor P2Y6
chr6_+_36678699 Show fit	0.48	ENST00000405375.5 ENST00000244741.10 ENST00000373711.3	CDKN1A Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase inhibitor 1A
chr4_-_186555567 Show fit	0.48	ENST00000307161.5	MTNR1A Ensembl NCBI GeneCards UniProt Show fit	melatonin receptor 1A
chr11_-_62984957 Show fit	0.42	ENST00000377871.7 ENST00000360421.9	SLC22A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22 member 6
chr7_-_116030750 Show fit	0.41	ENST00000265440.12 ENST00000320239.11	TFEC Ensembl NCBI GeneCards UniProt Show fit	transcription factor EC
chr10_+_113553039 Show fit	0.40	ENST00000351270.4	HABP2 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan binding protein 2
chr1_-_7940825 Show fit	0.36	ENST00000377507.8	TNFRSF9 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 9
chr6_-_32853618 Show fit	0.36	ENST00000354258.5	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP binding cassette subfamily B member
chr6_+_52186373 Show fit	0.32	ENST00000648244.1	IL17A Ensembl NCBI GeneCards UniProt Show fit	interleukin 17A
chr1_+_15684284 Show fit	0.29	ENST00000375799.8 ENST00000375793.2	PLEKHM2 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology and RUN domain containing M2
chr3_-_165196369 Show fit	0.27	ENST00000475390.2	SLITRK3 Ensembl NCBI GeneCards UniProt Show fit	SLIT and NTRK like family member 3
chr12_-_48852153 Show fit	0.24	ENST00000308025.8	DDX23 Ensembl NCBI GeneCards UniProt Show fit	DEAD-box helicase 23
chr6_+_31571957 Show fit	0.20	ENST00000454783.5	LTA Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin alpha
chr1_+_161581339 Show fit	0.16	ENST00000543859.5 ENST00000611236.1	FCGR2C Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor IIc (gene/pseudogene)
chr9_-_92404559 Show fit	0.16	ENST00000262551.8 ENST00000375561.10	OGN Ensembl NCBI GeneCards UniProt Show fit	osteoglycin
chr3_-_149221811 Show fit	0.16	ENST00000455472.3 ENST00000264613.11	CP Ensembl NCBI GeneCards UniProt Show fit	ceruloplasmin
chr18_+_63476927 Show fit	0.11	ENST00000489441.5 ENST00000382771.9 ENST00000424602.1	SERPINB5 Ensembl NCBI GeneCards UniProt Show fit	serpin family B member 5
chr19_-_51372686 Show fit	0.09	ENST00000595217.1	NKG7 Ensembl NCBI GeneCards UniProt Show fit	natural killer cell granule protein 7
chr8_-_94262308 Show fit	0.05	ENST00000297596.3 ENST00000396194.6	GEM Ensembl NCBI GeneCards UniProt Show fit	GTP binding protein overexpressed in skeletal muscle

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.3	21.7	GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
4.3	21.4	GO:1902847	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
2.9	8.6	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
2.6	43.6	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
2.0	8.2	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
2.0	6.0	GO:0061760	antifungal innate immune response(GO:0061760)
1.8	5.4	GO:0060435	branchiomeric skeletal muscle development(GO:0014707) bronchiole development(GO:0060435) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.4	4.3	GO:0098928	presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
1.3	6.5	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
1.3	5.1	GO:1902159	regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
1.2	11.1	GO:0090487	toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
1.2	3.6	GO:0070317	negative regulation of G0 to G1 transition(GO:0070317)
1.2	9.3	GO:0061709	reticulophagy(GO:0061709)
1.1	4.3	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
1.1	3.2	GO:0060474	positive regulation of sperm motility involved in capacitation(GO:0060474)
1.0	6.9	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
1.0	2.9	GO:0002436	immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
0.7	2.2	GO:0007343	egg activation(GO:0007343)
0.7	4.8	GO:0030885	regulation of myeloid dendritic cell activation(GO:0030885)
0.7	13.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.6	6.4	GO:0006537	glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.6	1.9	GO:1904596	regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.6	1.8	GO:1904479	negative regulation of intestinal absorption(GO:1904479) response to iron ion starvation(GO:1990641)
0.6	2.8	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.5	3.8	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.5	24.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.5	4.0	GO:0046684	response to pyrethroid(GO:0046684)
0.5	2.7	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.4	4.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.4	9.0	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.4	3.4	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.4	1.3	GO:0071284	cellular response to lead ion(GO:0071284)
0.4	2.9	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.4	3.2	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.4	0.8	GO:0050955	thermoception(GO:0050955)
0.4	4.3	GO:0043129	surfactant homeostasis(GO:0043129)
0.4	2.9	GO:0060574	intestinal epithelial cell maturation(GO:0060574)
0.3	1.3	GO:1990834	response to odorant(GO:1990834)
0.3	1.3	GO:0002370	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.3	1.0	GO:0046967	cytosol to ER transport(GO:0046967)
0.3	1.7	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.3	2.5	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.3	4.6	GO:0003322	pancreatic A cell development(GO:0003322)
0.2	3.2	GO:0070327	thyroid hormone transport(GO:0070327)
0.2	8.8	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2	6.0	GO:0071420	cellular response to histamine(GO:0071420)
0.2	1.9	GO:0007288	sperm axoneme assembly(GO:0007288)
0.2	1.6	GO:0015747	urate transport(GO:0015747)
0.2	2.2	GO:0048251	elastic fiber assembly(GO:0048251)
0.2	3.1	GO:0099612	protein localization to axon(GO:0099612)
0.2	4.3	GO:0042832	defense response to protozoan(GO:0042832)
0.2	2.8	GO:1902260	negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2	4.8	GO:0048266	behavioral response to pain(GO:0048266)
0.2	4.8	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.2	1.6	GO:0008343	adult feeding behavior(GO:0008343)
0.2	1.1	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1	1.7	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	3.3	GO:0014850	response to muscle activity(GO:0014850)
0.1	1.7	GO:0000722	telomere maintenance via recombination(GO:0000722)
0.1	4.6	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.1	1.2	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
0.1	1.0	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1	1.9	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	8.3	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1	2.3	GO:0006098	pentose-phosphate shunt(GO:0006098)
0.1	3.0	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.1	1.1	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.1	5.4	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.1	1.7	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.1	0.3	GO:1903527	positive regulation of membrane tubulation(GO:1903527)
0.1	3.4	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.1	0.8	GO:0045617	positive regulation of keratinocyte proliferation(GO:0010838) negative regulation of keratinocyte differentiation(GO:0045617)
0.1	8.8	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.1	5.4	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1	0.8	GO:0008090	retrograde axonal transport(GO:0008090)
0.1	1.6	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.1	1.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1	0.4	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.1	4.0	GO:0030032	lamellipodium assembly(GO:0030032)
0.1	0.3	GO:0097398	response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1	2.6	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	5.6	GO:0098869	cellular oxidant detoxification(GO:0098869)
0.0	0.5	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	18.1	GO:0051056	regulation of small GTPase mediated signal transduction(GO:0051056)
0.0	2.0	GO:0060976	coronary vasculature development(GO:0060976)
0.0	1.2	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	1.7	GO:0042104	positive regulation of activated T cell proliferation(GO:0042104)
0.0	1.5	GO:0030220	platelet formation(GO:0030220)
0.0	10.2	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.0	2.0	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652)
0.0	1.3	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.5	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	3.5	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0	2.7	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.0	1.5	GO:0001578	microtubule bundle formation(GO:0001578)
0.0	0.0	GO:1901842	negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0	0.2	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.6	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.0	2.4	GO:0060271	cilium morphogenesis(GO:0060271)
0.0	0.2	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.0	0.6	GO:0016266	O-glycan processing(GO:0016266)
0.0	4.0	GO:0032259	methylation(GO:0032259)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.0	20.9	GO:0098843	postsynaptic endocytic zone(GO:0098843)
2.4	21.7	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
1.4	4.3	GO:0098831	cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569)
1.4	21.4	GO:0097418	neurofibrillary tangle(GO:0097418)
1.0	3.0	GO:0045298	tubulin complex(GO:0045298)
0.7	5.8	GO:0005579	membrane attack complex(GO:0005579)
0.6	2.9	GO:0070557	PCNA-p21 complex(GO:0070557)
0.6	2.9	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.5	3.1	GO:1990769	proximal neuron projection(GO:1990769)
0.5	9.3	GO:0031089	platelet dense granule lumen(GO:0031089)
0.5	6.5	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.4	2.8	GO:1990635	proximal dendrite(GO:1990635)
0.4	4.3	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.4	5.4	GO:0097433	dense body(GO:0097433)
0.4	8.8	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.3	3.2	GO:0097524	sperm plasma membrane(GO:0097524)
0.2	1.8	GO:0045179	apical cortex(GO:0045179)
0.2	7.9	GO:0034451	centriolar satellite(GO:0034451)
0.2	1.0	GO:0042825	TAP complex(GO:0042825)
0.2	45.0	GO:0030426	growth cone(GO:0030426)
0.2	1.5	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.2	1.7	GO:0046581	intercellular canaliculus(GO:0046581)
0.2	0.8	GO:0031673	H zone(GO:0031673)
0.1	6.0	GO:1902711	GABA-A receptor complex(GO:1902711)
0.1	9.3	GO:0005801	cis-Golgi network(GO:0005801)
0.1	3.8	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.1	9.5	GO:0015030	Cajal body(GO:0015030)
0.1	4.8	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	2.6	GO:0030992	intraciliary transport particle B(GO:0030992)
0.1	3.5	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	3.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	7.3	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	3.4	GO:0016592	mediator complex(GO:0016592)
0.1	5.5	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	1.9	GO:0005682	U5 snRNP(GO:0005682)
0.1	4.8	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	1.1	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.1	3.2	GO:0001772	immunological synapse(GO:0001772)
0.1	1.0	GO:0016342	catenin complex(GO:0016342)
0.1	1.9	GO:0042629	mast cell granule(GO:0042629)
0.0	5.4	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	9.4	GO:0072562	blood microparticle(GO:0072562)
0.0	1.3	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	5.4	GO:0031225	anchored component of membrane(GO:0031225)
0.0	4.2	GO:0005796	Golgi lumen(GO:0005796)
0.0	2.5	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	2.9	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	1.3	GO:0034707	chloride channel complex(GO:0034707)
0.0	3.4	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.5	GO:0035580	specific granule lumen(GO:0035580)
0.0	2.8	GO:0016605	PML body(GO:0016605)
0.0	2.3	GO:0034705	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0	0.6	GO:0016235	aggresome(GO:0016235)
0.0	2.8	GO:0042383	sarcolemma(GO:0042383)
0.0	7.7	GO:0045177	apical part of cell(GO:0045177)
0.0	2.7	GO:0005875	microtubule associated complex(GO:0005875)
0.0	7.7	GO:0000785	chromatin(GO:0000785)
0.0	2.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	2.7	GO:0043235	receptor complex(GO:0043235)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.4	21.7	GO:0016019	peptidoglycan receptor activity(GO:0016019)
3.4	10.2	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
2.6	20.9	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
2.2	11.1	GO:0045174	glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
1.7	8.3	GO:0004522	ribonuclease A activity(GO:0004522)
1.6	8.2	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
1.1	3.4	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
1.0	2.9	GO:0005260	channel-conductance-controlling ATPase activity(GO:0005260)
0.9	21.4	GO:0051787	misfolded protein binding(GO:0051787)
0.8	2.3	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.8	2.3	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.7	2.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.7	2.0	GO:0032093	SAM domain binding(GO:0032093)
0.6	1.9	GO:1904599	advanced glycation end-product binding(GO:1904599)
0.6	6.0	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.6	2.9	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.5	4.0	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.5	3.7	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.5	6.4	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.5	8.6	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.4	1.7	GO:0004909	interleukin-1, Type I, activating receptor activity(GO:0004909)
0.4	2.5	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4	3.2	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.4	3.5	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.3	1.7	GO:0019862	IgA binding(GO:0019862)
0.3	4.3	GO:0042608	T cell receptor binding(GO:0042608)
0.3	1.9	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3	4.6	GO:0030215	semaphorin receptor binding(GO:0030215)
0.3	6.9	GO:0070403	NAD+ binding(GO:0070403)
0.2	1.2	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.2	1.2	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.2	2.6	GO:0019864	IgG binding(GO:0019864)
0.2	4.3	GO:0005522	profilin binding(GO:0005522)
0.2	3.2	GO:0019957	C-C chemokine binding(GO:0019957)
0.2	2.9	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.2	1.2	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2	1.9	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.2	5.4	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2	4.8	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2	5.6	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.2	1.0	GO:0015440	peptide-transporting ATPase activity(GO:0015440) TAP2 binding(GO:0046979)
0.2	0.5	GO:0008502	melatonin receptor activity(GO:0008502)
0.2	5.4	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	1.7	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2	1.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023)
0.1	4.8	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	5.6	GO:0017091	AU-rich element binding(GO:0017091)
0.1	2.3	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.1	2.3	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1	2.8	GO:0070402	NADPH binding(GO:0070402)
0.1	8.2	GO:0050681	androgen receptor binding(GO:0050681)
0.1	1.1	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)
0.1	1.5	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.5	GO:0045029	UDP-activated nucleotide receptor activity(GO:0045029)
0.1	9.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	1.0	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	4.6	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.1	2.2	GO:0005521	lamin binding(GO:0005521)
0.1	1.7	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.1	0.4	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	3.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	8.0	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	1.6	GO:0008188	neuropeptide receptor activity(GO:0008188)
0.0	4.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	4.9	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.0	0.8	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	1.9	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	4.3	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	2.7	GO:0003777	microtubule motor activity(GO:0003777)
0.0	3.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	4.3	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	6.8	GO:0008168	methyltransferase activity(GO:0008168)
0.0	1.3	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	7.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	1.3	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	1.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	1.6	GO:0008528	G-protein coupled peptide receptor activity(GO:0008528)
0.0	3.0	GO:0008017	microtubule binding(GO:0008017)
0.0	1.8	GO:0005179	hormone activity(GO:0005179)
0.0	0.4	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	79.5	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.5	17.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.4	3.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.4	4.9	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.3	21.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	8.6	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	8.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	3.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	3.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	4.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	2.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	2.7	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	2.9	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	1.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	6.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	8.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.4	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	1.5	PID LKB1 PATHWAY	LKB1 signaling events
0.0	4.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.3	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	1.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.7	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	2.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	1.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	21.7	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.8	20.9	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3	11.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.3	3.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.2	4.0	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2	4.3	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	2.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	4.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	2.7	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2	6.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2	3.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.2	24.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	9.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	6.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	2.9	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	5.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	3.6	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.1	4.9	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.1	13.0	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	3.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	4.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	1.9	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.1	1.9	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	1.9	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	4.0	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	4.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	16.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	11.9	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	3.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	6.4	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	3.1	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	3.2	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.1	2.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	2.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	4.8	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	1.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	1.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	3.4	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	2.0	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.4	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	7.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation

Results for STAT4

Z-value: 5.43

Motif logo

Transcription factors associated with STAT4

Activity-expression correlation:

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: