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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for T

Z-value: 5.04

Motif logo

Transcription factors associated with T

Gene Symbol Gene ID Gene Info
ENSG00000164458.10 TBXT

Activity-expression correlation:

Activity profile of T motif

Sorted Z-values of T motif

Network of associatons between targets according to the STRING database.

First level regulatory network of T

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_23799533 24.93 ENST00000429356.5
UDP-galactose-4-epimerase
chr12_-_122227491 19.65 ENST00000475784.1
ENST00000645606.1
novel protein
chr1_-_149927756 16.09 ENST00000271628.9
splicing factor 3b subunit 4
chr3_+_142596385 15.77 ENST00000457734.7
ENST00000483373.5
ENST00000475296.5
ENST00000495744.5
ENST00000476044.5
ENST00000461644.5
ENST00000464320.5
plastin 1
chr9_+_36572854 15.64 ENST00000543751.5
ENST00000536860.5
ENST00000541717.4
ENST00000536329.5
ENST00000536987.5
ENST00000298048.7
ENST00000495529.5
ENST00000545008.5
maternal embryonic leucine zipper kinase
chr2_-_85409805 14.85 ENST00000449030.5
capping actin protein, gelsolin like
chrX_+_134460138 14.78 ENST00000298556.8
hypoxanthine phosphoribosyltransferase 1
chr20_+_35542038 14.73 ENST00000357394.8
ENST00000348547.7
ENST00000416206.5
ENST00000640748.1
ENST00000411577.5
ENST00000413587.5
ERGIC and golgi 3
chr15_+_78540405 13.66 ENST00000560217.5
ENST00000559082.5
ENST00000559948.5
ENST00000413382.6
ENST00000559146.5
ENST00000044462.12
ENST00000558281.5
proteasome 20S subunit alpha 4
chr12_+_53985138 13.40 ENST00000303460.5
homeobox C10
chr11_-_27722021 12.08 ENST00000314915.6
brain derived neurotrophic factor
chr20_+_1135217 11.83 ENST00000381898.5
proteasome inhibitor subunit 1
chr2_-_199457931 10.58 ENST00000417098.6
SATB homeobox 2
chr12_-_56316002 8.85 ENST00000547423.5
ENST00000548360.1
ENST00000551475.5
novel protein
canopy FGF signaling regulator 2
chr16_-_88651015 8.81 ENST00000568278.1
ENST00000569359.5
ENST00000567174.5
ENST00000261623.8
cytochrome b-245 alpha chain
chr10_-_95290992 8.80 ENST00000329399.7
PDZ and LIM domain 1
chr10_+_5446601 8.64 ENST00000449083.5
ENST00000380359.3
neuroepithelial cell transforming 1
chr16_+_69187125 8.64 ENST00000336278.8
syntrophin beta 2
chr2_+_121737100 8.61 ENST00000455432.5
translin
chr12_-_56315890 8.57 ENST00000551286.1
ENST00000549318.5
canopy FGF signaling regulator 2
novel protein
chr2_+_57907621 8.50 ENST00000648897.1
ENST00000435505.6
ENST00000417641.6
VRK serine/threonine kinase 2
chr12_-_6851245 8.34 ENST00000540683.1
ENST00000229265.10
ENST00000535406.5
ENST00000422785.7
ENST00000538862.7
cell division cycle associated 3
chr9_-_72953047 8.17 ENST00000297785.8
ENST00000376939.5
aldehyde dehydrogenase 1 family member A1
chr7_-_95435329 7.70 ENST00000633192.1
paraoxonase 2
chr17_-_42154916 7.49 ENST00000592574.1
ENST00000550406.1
ENST00000547517.5
ENST00000346213.9
ENST00000393860.7
novel protein
RAB5C, member RAS oncogene family
chr16_+_85611401 7.48 ENST00000405402.6
Gse1 coiled-coil protein
chrX_+_110002635 7.44 ENST00000372072.7
transmembrane protein 164
chr1_-_114581589 7.38 ENST00000369541.4
BCAS2 pre-mRNA processing factor
chr21_+_29130630 7.36 ENST00000399926.5
ENST00000399928.6
MAP3K7 C-terminal like
chr6_+_43132472 7.29 ENST00000489707.5
protein tyrosine kinase 7 (inactive)
chr12_-_56315952 6.78 ENST00000273308.9
canopy FGF signaling regulator 2
chr11_-_111879425 6.70 ENST00000622211.4
novel protein
chr20_+_3209469 6.62 ENST00000380113.8
ENST00000455664.6
ENST00000399838.3
inosine triphosphatase
chr21_-_45563115 6.49 ENST00000650808.1
solute carrier family 19 member 1
chr7_-_76626127 6.40 ENST00000454397.1
POM121 and ZP3 fusion
chr7_+_107580454 5.94 ENST00000379117.6
ENST00000473124.1
B cell receptor associated protein 29
chr5_-_177351522 5.60 ENST00000513877.1
ENST00000515209.5
ENST00000514458.5
ENST00000502560.5
ENST00000303127.12
lectin, mannose binding 2
chr17_-_28335421 5.51 ENST00000578122.5
ENST00000579419.5
ENST00000585313.5
ENST00000578985.5
ENST00000577498.1
ENST00000585089.5
ENST00000357896.7
ENST00000395418.8
ENST00000588477.5
intraflagellar transport 20
chr14_-_45134454 5.50 ENST00000396062.4
FKBP prolyl isomerase 3
chr16_-_2264221 5.38 ENST00000566397.5
RNA binding protein with serine rich domain 1
chr5_+_86617967 5.28 ENST00000515763.1
cytochrome c oxidase subunit 7C
chr16_+_67562453 5.24 ENST00000646076.1
CCCTC-binding factor
chr16_+_69424634 5.24 ENST00000515314.6
ENST00000561792.6
ENST00000568237.1
cytochrome b5 type B
chr5_-_112922217 5.22 ENST00000379638.9
ENST00000513339.5
ENST00000504247.1
receptor accessory protein 5
chr19_+_11436044 5.14 ENST00000589838.5
protein kinase C substrate 80K-H
chr4_+_26320782 5.03 ENST00000514807.5
ENST00000348160.9
recombination signal binding protein for immunoglobulin kappa J region
chr4_-_151015713 5.01 ENST00000357115.9
LPS responsive beige-like anchor protein
chrX_+_51893533 4.99 ENST00000375722.5
ENST00000326587.12
ENST00000375695.2
MAGE family member D1
chr5_-_177006350 4.90 ENST00000377227.8
ubiquitin interaction motif containing 1
chr11_-_66345066 4.86 ENST00000359957.8
ENST00000425825.6
BRMS1 transcriptional repressor and anoikis regulator
chr10_-_46030585 4.73 ENST00000580070.5
ENST00000578454.5
ENST00000585056.5
ENST00000579039.2
ENST00000581486.6
nuclear receptor coactivator 4
chr12_+_19205294 4.64 ENST00000424268.5
pleckstrin homology domain containing A5
chr4_+_26320563 4.57 ENST00000361572.10
recombination signal binding protein for immunoglobulin kappa J region
chr6_-_31542339 4.55 ENST00000458640.5
DExD-box helicase 39B
chr16_+_67562514 4.44 ENST00000264010.10
ENST00000401394.6
ENST00000646771.1
CCCTC-binding factor
chr8_-_140800535 4.35 ENST00000521986.5
ENST00000523539.5
protein tyrosine kinase 2
chr5_+_86617919 3.98 ENST00000247655.4
ENST00000509578.1
cytochrome c oxidase subunit 7C
chr1_+_113929304 3.95 ENST00000426820.7
homeodomain interacting protein kinase 1
chr10_-_5017955 3.90 ENST00000604507.5
aldo-keto reductase family 1 member C2
chr17_-_20467535 3.87 ENST00000324290.5
ENST00000423676.8
galectin 9B
chr1_+_113929350 3.81 ENST00000369559.8
ENST00000626993.2
homeodomain interacting protein kinase 1
chr1_-_44986568 3.71 ENST00000372183.7
ENST00000360403.7
ENST00000620860.4
eukaryotic translation initiation factor 2B subunit gamma
chrX_+_101408198 3.63 ENST00000316594.6
heterogeneous nuclear ribonucleoprotein H2
chr1_+_113929600 3.57 ENST00000369558.5
ENST00000369561.8
homeodomain interacting protein kinase 1
chr6_-_106325416 3.36 ENST00000343245.7
autophagy related 5
chr19_+_11435619 3.25 ENST00000589126.5
ENST00000588269.1
ENST00000587509.5
ENST00000591462.6
ENST00000592741.5
ENST00000677123.1
ENST00000593101.5
ENST00000587327.5
protein kinase C substrate 80K-H
chr4_+_37960397 3.25 ENST00000504686.2
pituitary tumor-transforming 2
chr19_+_35031263 3.25 ENST00000640135.1
ENST00000596348.2
sodium voltage-gated channel beta subunit 1
chr21_-_25735026 3.05 ENST00000400099.5
ENST00000457143.6
ATP synthase peripheral stalk subunit F6
chr7_-_88220025 2.96 ENST00000419179.5
ENST00000265729.7
sorcin
chr1_+_113929859 2.94 ENST00000369555.6
homeodomain interacting protein kinase 1
chr2_+_161231078 2.89 ENST00000439442.1
TRAF family member associated NFKB activator
chr8_+_132775340 2.82 ENST00000622263.4
ENST00000220847.8
ENST00000395379.5
ENST00000395386.7
ENST00000485595.5
ENST00000337920.8
PHD finger protein 20 like 1
chr17_+_59893046 2.81 ENST00000393021.7
ENST00000225577.9
ENST00000443572.6
ENST00000406116.7
ribosomal protein S6 kinase B1
chr17_+_36210924 2.79 ENST00000615418.4
C-C motif chemokine ligand 4 like 2
chr22_+_19941733 2.78 ENST00000403184.5
ENST00000361682.11
ENST00000403710.5
ENST00000407537.5
ENST00000678868.1
catechol-O-methyltransferase
chr7_+_134891566 2.71 ENST00000424922.5
ENST00000495522.1
caldesmon 1
chr6_-_106325735 2.64 ENST00000635758.2
ENST00000369076.8
ENST00000636437.1
autophagy related 5
chr21_-_25734887 2.60 ENST00000400094.5
ENST00000284971.8
ATP synthase peripheral stalk subunit F6
chr19_-_43670153 2.60 ENST00000601723.5
ENST00000339082.7
ENST00000340093.8
plasminogen activator, urokinase receptor
chr12_-_48957445 2.57 ENST00000541959.5
ENST00000447318.6
ENST00000256682.9
ADP ribosylation factor 3
chr4_-_139084289 2.56 ENST00000510408.5
ENST00000379549.7
ENST00000358635.7
E74 like ETS transcription factor 2
chr20_-_62367304 2.45 ENST00000252999.7
laminin subunit alpha 5
chr10_-_22714531 2.38 ENST00000376573.9
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
chr1_-_120176450 2.30 ENST00000578049.4
SEC22 homolog B, vesicle trafficking protein
chr17_-_51046868 2.28 ENST00000510283.5
ENST00000510855.1
sperm associated antigen 9
chr1_+_88684513 2.27 ENST00000370513.9
protein kinase N2
chr16_-_10942443 2.20 ENST00000570440.2
ENST00000331808.5
Dexi homolog
chr1_-_224330121 2.17 ENST00000469968.5
ENST00000436927.5
ENST00000469075.5
ENST00000488718.5
ENST00000340871.8
ENST00000492281.5
ENST00000391875.6
ENST00000281701.11
ENST00000461546.2
ENST00000482491.5
nuclear VCP like
chr2_+_233692881 2.10 ENST00000305139.11
UDP glucuronosyltransferase family 1 member A6
chr6_-_26123910 1.99 ENST00000314332.5
ENST00000396984.1
H2B clustered histone 4
chr9_+_33750669 1.92 ENST00000361005.10
ENST00000342836.9
ENST00000429677.8
serine protease 3
chr12_-_52473798 1.89 ENST00000252250.7
keratin 6C
chr13_-_113864062 1.79 ENST00000327773.7
growth arrest specific 6
chr8_-_98942557 1.77 ENST00000523601.5
serine/threonine kinase 3
chr17_-_58007217 1.72 ENST00000258962.5
ENST00000582730.6
ENST00000584773.5
ENST00000585096.1
serine and arginine rich splicing factor 1
chr15_-_65517244 1.56 ENST00000341861.9
dipeptidyl peptidase 8
chr22_+_40045451 1.55 ENST00000402203.5
trinucleotide repeat containing adaptor 6B
chr1_+_27322145 1.50 ENST00000611517.4
ENST00000374076.9
transmembrane protein 222
chr1_+_27322218 1.49 ENST00000608611.5
ENST00000466759.5
ENST00000464813.5
ENST00000498220.1
transmembrane protein 222
chr12_-_52680398 1.42 ENST00000252244.3
keratin 1
chr2_-_85668172 1.14 ENST00000428225.5
ENST00000519937.7
surfactant protein B
chr6_+_26158115 1.09 ENST00000377777.5
ENST00000289316.2
H2B clustered histone 5
chr17_+_36211055 1.08 ENST00000617405.5
ENST00000617416.4
ENST00000613173.4
ENST00000620732.4
ENST00000620098.4
ENST00000620576.4
ENST00000620055.4
ENST00000610565.4
ENST00000620250.1
C-C motif chemokine ligand 4 like 2
chr1_+_158355894 1.07 ENST00000368162.2
CD1e molecule
chr11_-_1762403 1.01 ENST00000367196.4
cathepsin D
chr21_+_18244828 0.79 ENST00000299295.7
chondrolectin
chr6_+_29111560 0.77 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr1_+_88684222 0.73 ENST00000316005.11
ENST00000370521.8
protein kinase N2
chr2_-_215138603 0.72 ENST00000272895.12
ATP binding cassette subfamily A member 12
chr3_-_52409783 0.68 ENST00000470173.1
ENST00000296288.9
ENST00000460680.6
BRCA1 associated protein 1
chr12_-_89630552 0.65 ENST00000393164.6
ATPase plasma membrane Ca2+ transporting 1
chr12_-_68933161 0.59 ENST00000549781.1
ENST00000551568.6
ENST00000548262.5
carboxypeptidase M
chr11_-_65121780 0.39 ENST00000525297.5
ENST00000529259.1
FAU ubiquitin like and ribosomal protein S30 fusion
chr3_-_66500973 0.35 ENST00000383703.3
ENST00000273261.8
leucine rich repeats and immunoglobulin like domains 1
chr19_-_17264732 0.32 ENST00000252597.8
USH1 protein network component harmonin binding protein 1
chr5_+_7869104 0.32 ENST00000264668.6
ENST00000514220.5
ENST00000440940.7
ENST00000502550.5
ENST00000506877.1
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr12_+_113185702 0.30 ENST00000548278.2
RBPJ interacting and tubulin associated 1
chr1_+_151008412 0.20 ENST00000271620.8
ENST00000650332.1
ENST00000450884.5
ENST00000368937.5
ENST00000431193.5
ENST00000368936.5
prune exopolyphosphatase 1
chr22_+_19941813 0.18 ENST00000678769.1
catechol-O-methyltransferase
chr17_+_27631148 0.13 ENST00000313648.10
ENST00000395473.7
ENST00000577392.5
ENST00000584661.5
galectin 9
chr6_-_29045175 0.07 ENST00000377175.2
olfactory receptor family 2 subfamily W member 1
chr13_+_53028806 0.01 ENST00000219022.3
olfactomedin 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.1 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
3.2 15.8 GO:1902896 terminal web assembly(GO:1902896)
2.9 8.8 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
2.5 14.8 GO:0043103 hypoxanthine salvage(GO:0043103)
2.4 24.2 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
2.0 6.0 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
1.9 9.7 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
1.9 24.9 GO:0019388 galactose catabolic process(GO:0019388)
1.4 14.3 GO:0060235 lens induction in camera-type eye(GO:0060235)
1.4 9.6 GO:1905068 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
1.4 8.2 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
1.2 13.4 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
1.1 6.5 GO:0098838 methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
1.1 6.4 GO:0035803 egg coat formation(GO:0035803)
1.0 5.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
1.0 10.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9 2.8 GO:0048633 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of skeletal muscle tissue growth(GO:0048633)
0.9 2.6 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.8 7.3 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.8 14.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.7 6.6 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.7 8.6 GO:0051451 myoblast migration(GO:0051451)
0.7 4.9 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.7 16.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.7 3.9 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.6 4.5 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.6 4.9 GO:2000210 positive regulation of anoikis(GO:2000210)
0.6 1.8 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.6 7.5 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.6 8.6 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.5 3.2 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.5 3.0 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.5 2.9 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.5 9.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 5.5 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.4 3.0 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.4 3.7 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.4 2.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.4 4.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.4 1.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 8.4 GO:0006491 N-glycan processing(GO:0006491)
0.3 4.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.3 2.3 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.3 25.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.2 7.7 GO:0019372 lipoxygenase pathway(GO:0019372)
0.2 2.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.2 5.0 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2 0.7 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 5.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 1.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 0.7 GO:0035627 ceramide transport(GO:0035627)
0.2 2.1 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 4.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 10.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 0.3 GO:0048840 otolith development(GO:0048840)
0.1 0.7 GO:1990034 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.1 1.1 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 1.5 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 7.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 5.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 8.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 2.6 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 2.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 3.2 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.1 3.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0032831 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 2.2 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 2.5 GO:0001755 neural crest cell migration(GO:0001755)
0.0 1.9 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 11.0 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.1 GO:0007585 respiratory gaseous exchange(GO:0007585)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.8 GO:1990357 terminal web(GO:1990357)
1.8 5.5 GO:1902636 kinociliary basal body(GO:1902636)
1.5 13.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
1.2 14.9 GO:0008290 F-actin capping protein complex(GO:0008290)
1.2 6.0 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
1.1 13.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.1 9.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.8 2.5 GO:0043260 laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.7 9.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.7 16.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.6 4.5 GO:0005687 U4 snRNP(GO:0005687)
0.6 11.8 GO:0005839 proteasome core complex(GO:0005839)
0.6 8.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 5.4 GO:0061574 ASAP complex(GO:0061574)
0.5 4.7 GO:0044754 autolysosome(GO:0044754)
0.5 3.7 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.4 3.0 GO:0044326 dendritic spine neck(GO:0044326)
0.4 7.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 4.9 GO:0070531 BRCA1-A complex(GO:0070531)
0.2 8.6 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 0.7 GO:0035517 PR-DUB complex(GO:0035517)
0.2 21.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 2.6 GO:0071438 invadopodium membrane(GO:0071438)
0.2 5.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 4.9 GO:0070822 Sin3-type complex(GO:0070822)
0.2 2.7 GO:0030478 actin cap(GO:0030478)
0.1 1.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 10.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 3.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 16.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 7.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 3.3 GO:0045095 keratin filament(GO:0045095)
0.1 1.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 9.2 GO:0016605 PML body(GO:0016605)
0.1 4.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 3.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 9.7 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 2.4 GO:0005776 autophagosome(GO:0005776)
0.0 10.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 6.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 8.2 GO:0016607 nuclear speck(GO:0016607)
0.0 3.0 GO:0043197 dendritic spine(GO:0043197)
0.0 4.0 GO:0005938 cell cortex(GO:0005938)
0.0 7.1 GO:0005925 focal adhesion(GO:0005925)
0.0 1.1 GO:0043202 lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 24.9 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
3.2 9.7 GO:0043035 chromatin insulator sequence binding(GO:0043035)
3.0 12.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
2.2 6.6 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
1.9 7.7 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
1.4 5.5 GO:0002046 opsin binding(GO:0002046)
1.4 8.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.2 6.0 GO:0019776 Atg8 ligase activity(GO:0019776)
1.1 6.5 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
1.0 7.3 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.9 2.8 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.8 2.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.8 3.9 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.7 6.4 GO:0032190 acrosin binding(GO:0032190)
0.6 3.2 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.6 9.3 GO:0000150 recombinase activity(GO:0000150)
0.5 4.5 GO:0030621 U4 snRNA binding(GO:0030621)
0.5 13.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5 2.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.5 11.8 GO:0070628 proteasome binding(GO:0070628)
0.4 8.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.4 4.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.4 8.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 6.6 GO:0008432 JUN kinase binding(GO:0008432)
0.3 3.0 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.3 9.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 6.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 1.7 GO:0050733 DNA topoisomerase binding(GO:0044547) RS domain binding(GO:0050733)
0.2 14.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 7.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 4.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 5.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 8.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.7 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.1 3.0 GO:0004697 protein kinase C activity(GO:0004697)
0.1 11.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 4.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 30.6 GO:0051015 actin filament binding(GO:0051015)
0.1 1.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 1.1 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 2.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 7.5 GO:0019003 GDP binding(GO:0019003)
0.1 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.8 GO:0048018 receptor agonist activity(GO:0048018)
0.1 4.7 GO:0050681 androgen receptor binding(GO:0050681)
0.1 2.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 8.6 GO:0004519 endonuclease activity(GO:0004519)
0.1 3.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 5.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.3 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 1.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 17.5 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 5.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.2 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.2 PID IGF1 PATHWAY IGF1 pathway
0.1 17.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 9.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 2.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 8.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 4.9 PID ATM PATHWAY ATM pathway
0.1 8.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 14.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.0 PID RHOA PATHWAY RhoA signaling pathway
0.1 5.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 4.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 8.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.6 14.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 8.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.5 9.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 25.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 17.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 5.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 8.8 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.2 4.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 2.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 5.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.5 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.1 8.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 2.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 9.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 6.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 6.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.6 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 3.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 24.9 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 1.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 3.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 2.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 2.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 4.1 REACTOME TRANSLATION Genes involved in Translation