Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for TAF1
Z-value: 9.79
Motif logo
Transcription factors associated with TAF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TAF1
|
ENSG00000147133.17 | TAF1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAF1 | hg38_v1_chrX_+_71366290_71366368 | -0.53 | 4.9e-17 | Click! |
Activity profile of TAF1 motif
Sorted Z-values of TAF1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TAF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 51.3 | 205.1 | GO:0006169 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) |
| 49.7 | 149.1 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 49.2 | 49.2 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 33.6 | 134.5 | GO:0000961 | negative regulation of mitochondrial RNA catabolic process(GO:0000961) |
| 30.5 | 91.5 | GO:2000681 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 28.7 | 143.4 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 27.2 | 81.7 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 26.0 | 51.9 | GO:0031990 | mRNA export from nucleus in response to heat stress(GO:0031990) |
| 25.7 | 77.2 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 25.2 | 125.8 | GO:0006167 | AMP biosynthetic process(GO:0006167) |
| 25.1 | 125.3 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 24.6 | 73.8 | GO:1902269 | positive regulation of polyamine transmembrane transport(GO:1902269) |
| 24.2 | 96.8 | GO:1904569 | regulation of selenocysteine incorporation(GO:1904569) |
| 23.3 | 116.5 | GO:1902904 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 22.7 | 68.1 | GO:1902822 | lysosomal membrane organization(GO:0097212) regulation of late endosome to lysosome transport(GO:1902822) |
| 22.3 | 89.3 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 22.3 | 111.4 | GO:0040030 | regulation of molecular function, epigenetic(GO:0040030) |
| 21.5 | 64.5 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 21.5 | 64.4 | GO:0043461 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 20.6 | 103.2 | GO:0043634 | polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046) |
| 20.6 | 144.4 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 20.4 | 61.3 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 19.5 | 312.8 | GO:0043248 | proteasome assembly(GO:0043248) |
| 19.4 | 135.9 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 19.2 | 57.7 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 19.2 | 38.5 | GO:0061198 | fungiform papilla formation(GO:0061198) |
| 18.9 | 56.6 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 18.2 | 54.7 | GO:0006311 | meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520) |
| 18.1 | 18.1 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
| 18.1 | 325.8 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 18.0 | 54.1 | GO:0036265 | RNA (guanine-N7)-methylation(GO:0036265) rRNA (guanine-N7)-methylation(GO:0070476) |
| 17.4 | 69.7 | GO:0051697 | protein delipidation(GO:0051697) |
| 17.2 | 68.7 | GO:0048205 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 17.1 | 153.8 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 16.9 | 168.5 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 16.6 | 116.1 | GO:0033183 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 16.0 | 191.5 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 15.9 | 47.8 | GO:0003064 | regulation of heart rate by hormone(GO:0003064) negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 15.9 | 158.8 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 15.7 | 188.5 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 15.4 | 138.6 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 14.9 | 14.9 | GO:0097695 | establishment of RNA localization to telomere(GO:0097694) establishment of macromolecular complex localization to telomere(GO:0097695) |
| 14.9 | 237.8 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 14.8 | 59.3 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 14.8 | 44.3 | GO:0007174 | epidermal growth factor catabolic process(GO:0007174) |
| 14.7 | 44.1 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 13.7 | 13.7 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 13.6 | 54.5 | GO:1904117 | response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 13.5 | 26.9 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 13.0 | 39.0 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 12.8 | 192.3 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 12.8 | 38.3 | GO:1905053 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 12.7 | 962.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 12.6 | 100.4 | GO:0033523 | histone H2B ubiquitination(GO:0033523) |
| 12.5 | 50.2 | GO:0070370 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 12.3 | 73.9 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 12.3 | 36.8 | GO:0002192 | IRES-dependent translational initiation(GO:0002192) |
| 12.2 | 122.5 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 12.2 | 73.2 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 11.9 | 35.7 | GO:0007057 | spindle assembly involved in female meiosis I(GO:0007057) |
| 11.9 | 154.2 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 11.7 | 105.6 | GO:0060699 | regulation of endoribonuclease activity(GO:0060699) |
| 11.7 | 70.1 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 11.3 | 33.8 | GO:0090155 | negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) |
| 11.3 | 45.0 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 11.1 | 88.7 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 11.1 | 33.2 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 11.0 | 33.1 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
| 10.7 | 96.3 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 10.5 | 31.5 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 10.5 | 52.3 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 10.4 | 62.5 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 10.3 | 61.9 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 10.2 | 173.0 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 10.2 | 30.5 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 10.1 | 40.4 | GO:0043335 | protein unfolding(GO:0043335) |
| 10.1 | 70.4 | GO:0080009 | mRNA methylation(GO:0080009) |
| 10.0 | 70.1 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 9.8 | 59.1 | GO:0035965 | cardiolipin acyl-chain remodeling(GO:0035965) |
| 9.7 | 38.9 | GO:0006272 | leading strand elongation(GO:0006272) |
| 9.6 | 38.3 | GO:0070269 | pyroptosis(GO:0070269) |
| 9.6 | 19.1 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 9.6 | 76.5 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 9.5 | 104.7 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 9.4 | 112.2 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 9.1 | 45.7 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 9.0 | 45.0 | GO:1902047 | polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) |
| 8.9 | 26.8 | GO:0036446 | peptidyl-serine ADP-ribosylation(GO:0018312) myofibroblast differentiation(GO:0036446) mitochondrial DNA repair(GO:0043504) regulation of myofibroblast differentiation(GO:1904760) |
| 8.9 | 71.5 | GO:0033484 | regulation of protein ADP-ribosylation(GO:0010835) nitric oxide homeostasis(GO:0033484) |
| 8.8 | 70.8 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 8.6 | 138.2 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 8.6 | 51.7 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 8.4 | 33.8 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 8.4 | 42.0 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 8.2 | 90.3 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 8.2 | 319.7 | GO:0045841 | negative regulation of mitotic metaphase/anaphase transition(GO:0045841) mitotic spindle checkpoint(GO:0071174) |
| 8.1 | 154.2 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 8.0 | 32.2 | GO:0009838 | abscission(GO:0009838) |
| 8.0 | 23.9 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 7.6 | 30.5 | GO:0007538 | primary sex determination(GO:0007538) |
| 7.6 | 90.9 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 7.5 | 105.5 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 7.5 | 30.0 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 7.5 | 29.9 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 7.5 | 59.7 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 7.2 | 79.6 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 7.2 | 86.4 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 7.2 | 64.4 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 7.2 | 500.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 7.1 | 42.8 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) |
| 7.0 | 49.1 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 6.8 | 34.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 6.8 | 61.0 | GO:1900223 | positive regulation of beta-amyloid clearance(GO:1900223) |
| 6.7 | 27.0 | GO:0051182 | coenzyme transport(GO:0051182) |
| 6.7 | 53.9 | GO:1904798 | positive regulation of core promoter binding(GO:1904798) |
| 6.7 | 20.1 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 6.7 | 20.0 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 6.7 | 26.6 | GO:0072369 | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) |
| 6.6 | 59.5 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 6.5 | 19.6 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 6.4 | 96.1 | GO:0000338 | protein deneddylation(GO:0000338) |
| 6.4 | 83.1 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 6.4 | 31.9 | GO:0070900 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 6.4 | 19.1 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 6.3 | 31.5 | GO:1902966 | regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
| 6.3 | 75.2 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 6.1 | 42.5 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
| 6.0 | 131.2 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 5.9 | 65.2 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 5.9 | 58.7 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 5.8 | 46.7 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 5.8 | 40.4 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 5.8 | 86.3 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 5.7 | 229.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 5.6 | 44.9 | GO:0007008 | outer mitochondrial membrane organization(GO:0007008) |
| 5.6 | 61.2 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 5.6 | 5.6 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 5.5 | 66.5 | GO:0046689 | response to mercury ion(GO:0046689) |
| 5.5 | 16.6 | GO:0018160 | peptidyl-pyrromethane cofactor linkage(GO:0018160) |
| 5.5 | 16.5 | GO:1901388 | regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389) |
| 5.4 | 16.2 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
| 5.3 | 74.4 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 5.3 | 26.5 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 5.2 | 41.8 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 5.1 | 30.8 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 5.1 | 35.5 | GO:0043144 | snoRNA processing(GO:0043144) |
| 5.0 | 110.1 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 4.9 | 19.7 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 4.9 | 24.3 | GO:0040031 | snRNA modification(GO:0040031) |
| 4.9 | 14.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 4.9 | 9.7 | GO:0090230 | regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234) |
| 4.8 | 38.5 | GO:1901836 | regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836) |
| 4.8 | 105.4 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 4.8 | 71.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 4.7 | 18.9 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 4.7 | 149.8 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 4.7 | 37.4 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 4.7 | 37.3 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 4.7 | 23.3 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 4.6 | 106.4 | GO:0046931 | pore complex assembly(GO:0046931) |
| 4.6 | 13.9 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 4.6 | 13.9 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 4.6 | 96.9 | GO:0060148 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 4.6 | 9.2 | GO:1902415 | regulation of mRNA binding(GO:1902415) regulation of RNA binding(GO:1905214) |
| 4.5 | 35.7 | GO:0002759 | regulation of antimicrobial humoral response(GO:0002759) |
| 4.4 | 289.1 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 4.4 | 35.5 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 4.4 | 22.0 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 4.4 | 8.8 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 4.3 | 26.1 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 4.3 | 17.3 | GO:0003290 | atrial septum secundum morphogenesis(GO:0003290) |
| 4.3 | 42.9 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 4.3 | 59.9 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 4.3 | 12.8 | GO:0002101 | tRNA wobble cytosine modification(GO:0002101) |
| 4.2 | 34.0 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 4.2 | 12.6 | GO:0032707 | negative regulation of interleukin-23 production(GO:0032707) |
| 4.2 | 29.2 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 4.2 | 20.8 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 4.2 | 12.5 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 4.1 | 16.5 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 4.1 | 41.0 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 4.1 | 24.5 | GO:0015680 | intracellular copper ion transport(GO:0015680) |
| 4.0 | 20.1 | GO:0097240 | telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 4.0 | 19.9 | GO:1900063 | regulation of peroxisome organization(GO:1900063) |
| 3.9 | 75.0 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 3.9 | 39.4 | GO:0019064 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 3.9 | 23.6 | GO:0052205 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 3.9 | 7.7 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 3.8 | 34.6 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 3.8 | 11.5 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 3.8 | 34.4 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 3.8 | 11.4 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 3.8 | 15.1 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 3.8 | 37.6 | GO:0007379 | segment specification(GO:0007379) |
| 3.7 | 22.5 | GO:0003057 | regulation of the force of heart contraction by chemical signal(GO:0003057) |
| 3.7 | 14.8 | GO:0000451 | rRNA 2'-O-methylation(GO:0000451) |
| 3.7 | 69.9 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 3.7 | 22.0 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 3.7 | 21.9 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 3.6 | 7.3 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 3.6 | 68.4 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 3.6 | 46.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 3.6 | 21.5 | GO:0018343 | protein farnesylation(GO:0018343) |
| 3.6 | 49.7 | GO:0034134 | toll-like receptor 2 signaling pathway(GO:0034134) |
| 3.5 | 506.7 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 3.5 | 242.3 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 3.4 | 1192.8 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 3.4 | 24.1 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 3.4 | 48.0 | GO:0000154 | rRNA modification(GO:0000154) |
| 3.4 | 102.0 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 3.3 | 29.9 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 3.3 | 39.6 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 3.3 | 19.7 | GO:0070987 | error-free translesion synthesis(GO:0070987) |
| 3.3 | 9.8 | GO:0002585 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) |
| 3.3 | 13.0 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 3.2 | 9.7 | GO:0032954 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 3.2 | 12.9 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 3.2 | 54.5 | GO:0030497 | fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761) |
| 3.2 | 15.9 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 3.1 | 34.0 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 3.1 | 49.3 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 3.1 | 9.2 | GO:0001189 | RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189) |
| 3.1 | 21.4 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 3.0 | 48.6 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 3.0 | 18.1 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 3.0 | 90.4 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 3.0 | 27.0 | GO:1900086 | regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086) |
| 3.0 | 92.6 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 3.0 | 9.0 | GO:0048633 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 3.0 | 35.6 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) |
| 3.0 | 11.9 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 3.0 | 50.2 | GO:0030488 | tRNA methylation(GO:0030488) |
| 2.9 | 20.6 | GO:0048102 | autophagic cell death(GO:0048102) |
| 2.8 | 42.5 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 2.8 | 39.2 | GO:0043622 | cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660) |
| 2.8 | 30.8 | GO:0032025 | response to cobalt ion(GO:0032025) |
| 2.8 | 16.6 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 2.7 | 211.5 | GO:0006413 | translational initiation(GO:0006413) |
| 2.7 | 10.9 | GO:0018201 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201) |
| 2.7 | 171.5 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 2.7 | 19.0 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 2.7 | 16.1 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 2.6 | 42.2 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 2.6 | 15.6 | GO:0042255 | ribosome assembly(GO:0042255) |
| 2.6 | 12.8 | GO:0051415 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 2.5 | 12.7 | GO:0016240 | autophagosome docking(GO:0016240) |
| 2.5 | 37.5 | GO:0000715 | nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 2.4 | 31.2 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 2.4 | 11.9 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 2.4 | 11.9 | GO:0019081 | viral translation(GO:0019081) |
| 2.3 | 190.5 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 2.3 | 23.1 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
| 2.3 | 6.9 | GO:0034499 | late endosome to Golgi transport(GO:0034499) |
| 2.3 | 115.6 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 2.3 | 53.2 | GO:0006491 | N-glycan processing(GO:0006491) |
| 2.3 | 45.8 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 2.3 | 9.0 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 2.2 | 87.7 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
| 2.2 | 13.3 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 2.2 | 28.9 | GO:0090110 | cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110) |
| 2.2 | 24.4 | GO:0051451 | myoblast migration(GO:0051451) |
| 2.2 | 99.4 | GO:0001881 | receptor recycling(GO:0001881) |
| 2.2 | 28.7 | GO:0045008 | depyrimidination(GO:0045008) |
| 2.2 | 43.6 | GO:0031958 | corticosteroid receptor signaling pathway(GO:0031958) glucocorticoid receptor signaling pathway(GO:0042921) |
| 2.1 | 53.4 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 2.1 | 19.1 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 2.1 | 102.0 | GO:0031663 | lipopolysaccharide-mediated signaling pathway(GO:0031663) |
| 2.0 | 32.7 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 2.0 | 10.1 | GO:1901090 | regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094) |
| 2.0 | 6.0 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 1.9 | 21.4 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 1.9 | 34.9 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 1.9 | 17.3 | GO:0015886 | heme transport(GO:0015886) |
| 1.9 | 9.4 | GO:0035624 | receptor transactivation(GO:0035624) |
| 1.9 | 9.4 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 1.9 | 11.2 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 1.9 | 24.1 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 1.8 | 24.0 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 1.8 | 14.7 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 1.8 | 27.5 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 1.8 | 3.6 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 1.8 | 21.6 | GO:0098779 | mitophagy in response to mitochondrial depolarization(GO:0098779) |
| 1.8 | 8.9 | GO:1904753 | positive regulation of heart rate by epinephrine(GO:0003065) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) |
| 1.8 | 7.1 | GO:0032913 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 1.8 | 8.9 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 1.8 | 51.0 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 1.7 | 12.2 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 1.7 | 12.0 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 1.7 | 45.8 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 1.7 | 6.7 | GO:0051799 | negative regulation of hair follicle development(GO:0051799) |
| 1.7 | 33.6 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 1.6 | 22.7 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 1.6 | 16.2 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
| 1.6 | 14.5 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 1.6 | 6.4 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 1.6 | 12.5 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 1.5 | 39.3 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 1.5 | 44.8 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
| 1.5 | 35.7 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 1.5 | 51.3 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 1.5 | 7.3 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 1.4 | 7.2 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) |
| 1.4 | 18.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 1.4 | 1.4 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 1.4 | 15.1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 1.4 | 6.8 | GO:0070897 | DNA-templated transcriptional preinitiation complex assembly(GO:0070897) |
| 1.4 | 17.7 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 1.4 | 34.1 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 1.3 | 6.4 | GO:1902659 | regulation of glucose mediated signaling pathway(GO:1902659) |
| 1.3 | 158.3 | GO:0008380 | RNA splicing(GO:0008380) |
| 1.3 | 11.3 | GO:0071421 | manganese ion transmembrane transport(GO:0071421) |
| 1.3 | 41.3 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 1.3 | 85.1 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 1.2 | 59.7 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 1.2 | 8.5 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 1.1 | 2.3 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 1.1 | 6.8 | GO:0017182 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 1.1 | 2.2 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
| 1.1 | 3.3 | GO:0097534 | post-embryonic camera-type eye development(GO:0031077) lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 1.1 | 10.0 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 1.1 | 3.3 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 1.1 | 10.8 | GO:0000212 | meiotic spindle organization(GO:0000212) |
| 1.1 | 26.3 | GO:0006414 | translational elongation(GO:0006414) |
| 1.0 | 138.0 | GO:0000910 | cytokinesis(GO:0000910) |
| 1.0 | 196.8 | GO:0006457 | protein folding(GO:0006457) |
| 1.0 | 12.2 | GO:0043097 | pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) |
| 1.0 | 4.0 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 1.0 | 20.1 | GO:0006817 | phosphate ion transport(GO:0006817) |
| 1.0 | 21.1 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 1.0 | 10.9 | GO:0009303 | rRNA transcription(GO:0009303) |
| 1.0 | 7.8 | GO:0070459 | prolactin secretion(GO:0070459) |
| 1.0 | 3.9 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 1.0 | 2.9 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 1.0 | 8.6 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.9 | 5.5 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.9 | 41.5 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.9 | 7.1 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.9 | 9.6 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.9 | 19.1 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.9 | 6.0 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.8 | 7.6 | GO:0061101 | neuroendocrine cell differentiation(GO:0061101) |
| 0.8 | 23.0 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.8 | 6.6 | GO:0022615 | protein to membrane docking(GO:0022615) |
| 0.8 | 20.1 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 0.8 | 35.1 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.8 | 11.0 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.8 | 10.9 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.8 | 17.7 | GO:1901998 | toxin transport(GO:1901998) |
| 0.8 | 3.8 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.7 | 32.8 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.7 | 12.6 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.7 | 8.8 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
| 0.7 | 46.9 | GO:0007492 | endoderm development(GO:0007492) |
| 0.7 | 42.6 | GO:0090114 | COPII-coated vesicle budding(GO:0090114) |
| 0.7 | 9.7 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.7 | 25.6 | GO:0017145 | stem cell division(GO:0017145) |
| 0.7 | 4.6 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.6 | 2.5 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.6 | 8.2 | GO:0000060 | protein import into nucleus, translocation(GO:0000060) |
| 0.6 | 28.7 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 0.6 | 8.7 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.6 | 28.9 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.6 | 15.4 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.6 | 11.7 | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway(GO:0002755) |
| 0.6 | 2.9 | GO:0090235 | regulation of metaphase plate congression(GO:0090235) |
| 0.6 | 11.6 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.6 | 4.6 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.6 | 2.8 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.6 | 5.0 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.5 | 20.2 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.5 | 2.2 | GO:0046203 | spermidine catabolic process(GO:0046203) |
| 0.5 | 38.3 | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068) |
| 0.5 | 6.8 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.5 | 15.9 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.5 | 25.0 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
| 0.5 | 18.7 | GO:0051602 | response to electrical stimulus(GO:0051602) |
| 0.5 | 5.5 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.5 | 3.0 | GO:0060356 | leucine import(GO:0060356) |
| 0.5 | 33.4 | GO:0001909 | leukocyte mediated cytotoxicity(GO:0001909) |
| 0.5 | 22.9 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.5 | 15.4 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.5 | 6.4 | GO:0090382 | phagosome maturation(GO:0090382) |
| 0.5 | 3.4 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.5 | 6.8 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 0.5 | 7.6 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.5 | 10.3 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.5 | 11.5 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.5 | 7.3 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.4 | 66.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.4 | 9.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.4 | 44.8 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.4 | 5.1 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.4 | 11.0 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 0.4 | 19.6 | GO:0010595 | positive regulation of endothelial cell migration(GO:0010595) |
| 0.4 | 3.4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.4 | 3.3 | GO:0042182 | ketone catabolic process(GO:0042182) |
| 0.4 | 2.2 | GO:0032096 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
| 0.3 | 19.1 | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway(GO:2001243) |
| 0.3 | 16.1 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.3 | 3.7 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.3 | 20.9 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.3 | 7.1 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 4.4 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.2 | 5.1 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.2 | 3.4 | GO:0031063 | regulation of histone deacetylation(GO:0031063) |
| 0.2 | 17.7 | GO:0002504 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.2 | 12.5 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.2 | 1.4 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.2 | 5.1 | GO:0070228 | regulation of lymphocyte apoptotic process(GO:0070228) |
| 0.2 | 6.4 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.2 | 19.2 | GO:0051262 | protein tetramerization(GO:0051262) |
| 0.2 | 1.8 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.2 | 7.6 | GO:0001570 | vasculogenesis(GO:0001570) |
| 0.2 | 34.1 | GO:0001649 | osteoblast differentiation(GO:0001649) |
| 0.2 | 35.6 | GO:0009165 | nucleotide biosynthetic process(GO:0009165) |
| 0.1 | 1.0 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.1 | 3.4 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 27.9 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.1 | 0.9 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 1.9 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 9.2 | GO:0048675 | axon extension(GO:0048675) |
| 0.1 | 1.8 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 1.0 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 0.1 | 1.9 | GO:0042438 | melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438) |
| 0.1 | 8.2 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.1 | 1.0 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 0.1 | 1.1 | GO:0090398 | cellular senescence(GO:0090398) |
| 0.1 | 8.1 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.9 | GO:0040014 | regulation of multicellular organism growth(GO:0040014) |
| 0.0 | 0.2 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 0.9 | GO:0031016 | pancreas development(GO:0031016) |
| 0.0 | 0.1 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.8 | 304.1 | GO:0042382 | paraspeckles(GO:0042382) |
| 32.3 | 96.9 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 28.8 | 201.3 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 27.7 | 138.4 | GO:0089701 | U2AF(GO:0089701) |
| 27.5 | 192.7 | GO:0016589 | NURF complex(GO:0016589) |
| 23.2 | 92.8 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 21.9 | 87.5 | GO:0071920 | cleavage body(GO:0071920) |
| 20.6 | 123.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 18.4 | 128.7 | GO:0016272 | prefoldin complex(GO:0016272) |
| 18.3 | 201.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 18.3 | 91.5 | GO:0045293 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 18.2 | 54.5 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 18.1 | 198.9 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 17.9 | 502.2 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 17.8 | 89.0 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 17.5 | 69.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 16.3 | 48.9 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 15.9 | 207.0 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 15.6 | 46.8 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 15.5 | 434.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 14.8 | 44.3 | GO:0032419 | extrinsic component of lysosome membrane(GO:0032419) |
| 14.7 | 205.5 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 14.6 | 116.5 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 14.3 | 57.0 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 14.2 | 42.7 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 14.2 | 70.8 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 14.2 | 56.6 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 13.7 | 123.7 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 13.3 | 120.1 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 13.1 | 104.7 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 13.0 | 52.0 | GO:0044307 | dendritic branch(GO:0044307) |
| 12.9 | 90.0 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 12.7 | 50.6 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 12.1 | 48.5 | GO:1990423 | RZZ complex(GO:1990423) |
| 11.4 | 80.0 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 11.1 | 77.5 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 11.0 | 77.2 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 11.0 | 33.0 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 10.9 | 54.7 | GO:0032301 | MutSalpha complex(GO:0032301) MutSbeta complex(GO:0032302) |
| 10.9 | 131.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 10.7 | 42.7 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
| 10.4 | 229.3 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 10.3 | 134.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 10.2 | 40.7 | GO:1990246 | uniplex complex(GO:1990246) |
| 9.8 | 78.1 | GO:0034709 | methylosome(GO:0034709) |
| 9.7 | 38.8 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 9.7 | 203.1 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 9.7 | 96.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 9.6 | 38.3 | GO:0071159 | NF-kappaB complex(GO:0071159) |
| 9.4 | 28.2 | GO:0034455 | t-UTP complex(GO:0034455) |
| 9.2 | 73.9 | GO:0000796 | condensin complex(GO:0000796) |
| 8.7 | 156.0 | GO:0000346 | transcription export complex(GO:0000346) |
| 8.6 | 60.5 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 8.6 | 34.5 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 8.5 | 76.5 | GO:1990630 | IRE1-RACK1-PP2A complex(GO:1990630) |
| 8.4 | 25.3 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 8.4 | 25.2 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 8.3 | 91.6 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 8.3 | 25.0 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 8.3 | 174.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 8.3 | 49.6 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 8.2 | 24.7 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 8.2 | 32.6 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 8.0 | 8.0 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 8.0 | 80.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 8.0 | 23.9 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 7.9 | 39.4 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 7.8 | 38.9 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 7.7 | 23.2 | GO:0034657 | GID complex(GO:0034657) |
| 7.6 | 38.2 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) plasma membrane respiratory chain(GO:0070470) |
| 7.6 | 53.3 | GO:0031415 | NatA complex(GO:0031415) |
| 7.5 | 15.1 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 7.3 | 22.0 | GO:0035363 | histone locus body(GO:0035363) |
| 7.3 | 73.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 7.3 | 145.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 7.2 | 324.6 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 7.2 | 21.6 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 7.1 | 113.2 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 7.1 | 77.7 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 6.7 | 53.9 | GO:0031371 | ubiquitin conjugating enzyme complex(GO:0031371) |
| 6.6 | 59.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 6.5 | 64.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 6.4 | 83.7 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 6.4 | 114.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 6.2 | 359.6 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 6.1 | 30.7 | GO:0035061 | interchromatin granule(GO:0035061) |
| 6.0 | 24.1 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 6.0 | 155.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 5.8 | 11.5 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 5.8 | 69.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 5.8 | 51.8 | GO:0090543 | Flemming body(GO:0090543) |
| 5.7 | 68.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 5.7 | 62.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 5.6 | 106.5 | GO:0000812 | Swr1 complex(GO:0000812) |
| 5.5 | 33.3 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 5.5 | 33.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 5.5 | 105.0 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 5.5 | 16.5 | GO:1990917 | sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917) |
| 5.4 | 21.5 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 5.4 | 64.4 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 5.3 | 64.0 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 5.3 | 21.3 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 5.2 | 15.7 | GO:1903349 | omegasome membrane(GO:1903349) |
| 5.2 | 31.1 | GO:0005816 | spindle pole body(GO:0005816) |
| 5.1 | 61.3 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 5.1 | 55.8 | GO:0005638 | lamin filament(GO:0005638) |
| 5.0 | 114.2 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 5.0 | 39.6 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 4.9 | 14.8 | GO:0000805 | X chromosome(GO:0000805) |
| 4.5 | 13.6 | GO:0044393 | microspike(GO:0044393) |
| 4.5 | 59.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 4.4 | 57.5 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 4.4 | 84.0 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 4.3 | 17.1 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 4.2 | 12.7 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 4.2 | 437.4 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 4.2 | 772.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 4.2 | 45.8 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 4.1 | 45.4 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 4.1 | 36.6 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 4.0 | 44.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 4.0 | 28.0 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 3.7 | 47.8 | GO:0042555 | MCM complex(GO:0042555) |
| 3.6 | 65.3 | GO:0032433 | filopodium tip(GO:0032433) |
| 3.6 | 21.7 | GO:0032279 | axonemal microtubule(GO:0005879) asymmetric synapse(GO:0032279) |
| 3.6 | 28.8 | GO:0000780 | condensed nuclear chromosome, centromeric region(GO:0000780) |
| 3.6 | 10.7 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 3.4 | 30.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 3.4 | 44.1 | GO:0030677 | ribonuclease P complex(GO:0030677) |
| 3.4 | 50.8 | GO:0097346 | INO80-type complex(GO:0097346) |
| 3.3 | 60.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 3.3 | 130.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 3.2 | 48.1 | GO:0010369 | chromocenter(GO:0010369) |
| 3.1 | 102.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 3.1 | 92.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 3.0 | 21.2 | GO:0005827 | polar microtubule(GO:0005827) |
| 3.0 | 12.0 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 2.9 | 140.3 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 2.9 | 52.5 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 2.9 | 28.6 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 2.8 | 45.3 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 2.8 | 33.1 | GO:0030008 | TRAPP complex(GO:0030008) |
| 2.7 | 16.2 | GO:0000322 | storage vacuole(GO:0000322) |
| 2.7 | 291.4 | GO:0005840 | ribosome(GO:0005840) |
| 2.6 | 58.0 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 2.6 | 60.2 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 2.6 | 95.1 | GO:0000502 | proteasome complex(GO:0000502) |
| 2.4 | 65.7 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 2.4 | 48.1 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 2.4 | 50.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 2.4 | 66.5 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 2.3 | 16.3 | GO:0070187 | telosome(GO:0070187) |
| 2.2 | 17.9 | GO:0051286 | cell tip(GO:0051286) |
| 2.2 | 11.0 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 2.2 | 8.8 | GO:0030532 | small nuclear ribonucleoprotein complex(GO:0030532) |
| 2.2 | 6.6 | GO:0001940 | male pronucleus(GO:0001940) |
| 2.2 | 56.1 | GO:0005844 | polysome(GO:0005844) |
| 2.1 | 32.1 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 2.1 | 195.8 | GO:0005811 | lipid particle(GO:0005811) |
| 2.1 | 25.1 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 2.1 | 116.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 2.1 | 27.0 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 2.0 | 6.0 | GO:0018444 | translation release factor complex(GO:0018444) |
| 2.0 | 88.7 | GO:0002102 | podosome(GO:0002102) |
| 1.9 | 15.0 | GO:0072487 | MSL complex(GO:0072487) |
| 1.9 | 22.4 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 1.8 | 14.5 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 1.8 | 17.9 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 1.8 | 30.0 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 1.7 | 8.3 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 1.6 | 40.4 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 1.6 | 16.1 | GO:0097433 | dense body(GO:0097433) |
| 1.6 | 17.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.6 | 33.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 1.5 | 66.0 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 1.5 | 72.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 1.5 | 68.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 1.5 | 95.2 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 1.5 | 110.9 | GO:0031970 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 1.5 | 24.7 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 1.4 | 39.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 1.4 | 14.0 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 1.4 | 22.2 | GO:0035102 | PRC1 complex(GO:0035102) |
| 1.3 | 18.4 | GO:1902562 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 1.3 | 5.2 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 1.3 | 6.4 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 1.3 | 3.8 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 1.2 | 40.6 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 1.2 | 45.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 1.2 | 3.6 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 1.2 | 13.3 | GO:0032039 | integrator complex(GO:0032039) |
| 1.2 | 7.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 1.2 | 5.8 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 1.1 | 94.2 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 1.1 | 11.8 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 1.1 | 5.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 1.1 | 27.3 | GO:0030684 | preribosome(GO:0030684) |
| 1.0 | 34.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 1.0 | 138.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.9 | 44.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.9 | 85.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.9 | 58.2 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.9 | 158.2 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.9 | 8.8 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.9 | 6.1 | GO:0030891 | VCB complex(GO:0030891) |
| 0.9 | 191.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.9 | 56.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.8 | 20.2 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.8 | 29.3 | GO:0016592 | mediator complex(GO:0016592) |
| 0.8 | 8.9 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.8 | 5.6 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.8 | 2.3 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.8 | 250.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.7 | 9.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.7 | 61.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.7 | 12.9 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.7 | 11.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.7 | 22.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.7 | 33.2 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.6 | 15.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.6 | 19.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.6 | 3.7 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.6 | 10.4 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.6 | 45.7 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.6 | 144.5 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.6 | 64.6 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.6 | 19.1 | GO:0071564 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.5 | 7.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.5 | 2.5 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.5 | 7.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.5 | 3.2 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.4 | 0.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.4 | 6.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.4 | 33.0 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.4 | 35.4 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.4 | 10.9 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.3 | 13.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.3 | 5.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 13.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 1.4 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.2 | 10.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.2 | 52.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 19.5 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.2 | 71.3 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.2 | 0.9 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 47.9 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 3.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 18.3 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 2.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 4.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 169.8 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 2.8 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 2.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 4.0 | GO:0031968 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
| 0.0 | 1.7 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 51.3 | 205.1 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 37.1 | 111.4 | GO:0043035 | chromatin insulator sequence binding(GO:0043035) |
| 33.8 | 101.4 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 33.7 | 202.3 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 25.1 | 125.3 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 24.6 | 73.7 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
| 23.2 | 92.9 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 22.5 | 180.4 | GO:0050733 | RS domain binding(GO:0050733) |
| 21.9 | 87.5 | GO:0033677 | DNA/RNA helicase activity(GO:0033677) |
| 21.6 | 86.3 | GO:0070404 | NADH binding(GO:0070404) |
| 21.4 | 128.3 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 19.8 | 59.3 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 19.4 | 77.8 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 19.1 | 57.2 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 18.8 | 75.2 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 18.2 | 54.5 | GO:0080023 | 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023) |
| 17.8 | 89.0 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
| 17.6 | 105.8 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 17.5 | 69.9 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 17.3 | 173.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 16.5 | 66.1 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 16.5 | 49.5 | GO:0031755 | endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755) |
| 16.3 | 49.0 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 16.0 | 128.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 15.7 | 31.4 | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422) |
| 15.2 | 137.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 14.8 | 59.1 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 14.7 | 191.0 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 14.6 | 73.2 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 14.0 | 140.2 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 13.7 | 123.7 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 13.7 | 13.7 | GO:0061752 | telomeric repeat-containing RNA binding(GO:0061752) |
| 13.4 | 67.0 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 13.4 | 93.7 | GO:0032139 | dinucleotide insertion or deletion binding(GO:0032139) |
| 13.3 | 53.2 | GO:0004853 | uroporphyrinogen decarboxylase activity(GO:0004853) |
| 12.9 | 77.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 12.8 | 64.2 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 12.5 | 37.5 | GO:0004639 | phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 11.7 | 81.9 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 11.7 | 58.3 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 11.5 | 45.8 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 11.3 | 67.9 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 11.3 | 45.1 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 11.3 | 45.0 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 11.2 | 44.8 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 11.0 | 77.2 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 10.7 | 42.9 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 10.6 | 116.5 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 10.5 | 42.2 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 10.5 | 73.8 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 10.5 | 63.0 | GO:0036033 | mediator complex binding(GO:0036033) |
| 10.1 | 130.9 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 10.0 | 30.0 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 9.6 | 38.5 | GO:0004738 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 9.5 | 266.9 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 9.4 | 28.3 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 9.0 | 45.0 | GO:0042979 | ornithine decarboxylase regulator activity(GO:0042979) |
| 8.8 | 44.1 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 8.6 | 77.8 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 8.6 | 25.9 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 8.2 | 123.1 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 8.2 | 48.9 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 8.1 | 437.0 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 7.9 | 118.2 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 7.6 | 76.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 7.5 | 149.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 7.5 | 22.4 | GO:0033981 | D-dopachrome decarboxylase activity(GO:0033981) |
| 7.4 | 14.9 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 7.3 | 462.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 7.0 | 49.2 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 6.9 | 27.8 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 6.9 | 69.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 6.9 | 27.5 | GO:0032551 | pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551) |
| 6.9 | 34.4 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 6.8 | 20.3 | GO:0008523 | sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) |
| 6.7 | 20.0 | GO:0001132 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 6.7 | 272.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 6.6 | 33.2 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 6.6 | 32.8 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 6.5 | 39.0 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 6.4 | 70.8 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 6.4 | 102.0 | GO:0000150 | recombinase activity(GO:0000150) |
| 6.3 | 50.5 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 6.3 | 18.9 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 6.3 | 338.5 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 6.2 | 112.5 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 6.2 | 18.7 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 6.2 | 99.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 6.1 | 24.5 | GO:0016532 | superoxide dismutase copper chaperone activity(GO:0016532) |
| 6.1 | 206.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 5.9 | 41.6 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 5.8 | 40.4 | GO:0030911 | TPR domain binding(GO:0030911) |
| 5.6 | 44.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 5.5 | 16.6 | GO:0004418 | hydroxymethylbilane synthase activity(GO:0004418) |
| 5.5 | 44.1 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 5.4 | 114.2 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 5.4 | 21.6 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 5.4 | 26.9 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 5.4 | 21.5 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 5.2 | 15.6 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 5.2 | 41.3 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 5.1 | 30.6 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 5.1 | 183.2 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 5.1 | 136.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 5.0 | 44.7 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 4.9 | 34.6 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 4.9 | 1051.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 4.9 | 220.1 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 4.9 | 48.9 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 4.7 | 37.9 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 4.7 | 33.1 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 4.6 | 78.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 4.6 | 27.3 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 4.5 | 89.8 | GO:0070628 | proteasome binding(GO:0070628) |
| 4.5 | 26.9 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 4.4 | 155.2 | GO:0043022 | ribosome binding(GO:0043022) |
| 4.3 | 34.5 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 4.2 | 58.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 4.1 | 28.7 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 4.1 | 171.6 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 4.0 | 16.2 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 4.0 | 196.4 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 4.0 | 68.1 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 4.0 | 20.0 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 4.0 | 147.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 3.9 | 116.9 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 3.9 | 65.6 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 3.9 | 30.8 | GO:0015288 | porin activity(GO:0015288) |
| 3.7 | 76.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 3.6 | 147.5 | GO:0043175 | RNA polymerase core enzyme binding(GO:0043175) |
| 3.5 | 104.9 | GO:0008143 | poly(A) binding(GO:0008143) |
| 3.5 | 31.4 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 3.4 | 10.3 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 3.4 | 27.4 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 3.4 | 78.8 | GO:0005537 | mannose binding(GO:0005537) |
| 3.4 | 6.8 | GO:0001034 | RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034) |
| 3.4 | 13.5 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 3.3 | 33.1 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) poly(U) RNA binding(GO:0008266) |
| 3.3 | 95.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 3.3 | 9.8 | GO:0032090 | Pyrin domain binding(GO:0032090) |
| 3.2 | 9.7 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
| 3.1 | 231.1 | GO:0019003 | GDP binding(GO:0019003) |
| 3.0 | 90.9 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 3.0 | 12.0 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 3.0 | 11.9 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 2.9 | 17.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 2.9 | 14.6 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 2.9 | 64.0 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 2.9 | 14.5 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 2.8 | 36.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 2.7 | 51.9 | GO:0043495 | protein anchor(GO:0043495) |
| 2.7 | 10.9 | GO:0019107 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 2.7 | 48.9 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 2.6 | 60.0 | GO:0048156 | tau protein binding(GO:0048156) |
| 2.6 | 20.7 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 2.6 | 10.2 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 2.5 | 12.7 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 2.5 | 52.9 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 2.5 | 12.6 | GO:0051021 | GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 2.5 | 85.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 2.5 | 51.9 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 2.3 | 30.5 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 2.3 | 60.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 2.3 | 11.6 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 2.3 | 13.9 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 2.3 | 11.3 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 2.2 | 17.3 | GO:0015232 | heme transporter activity(GO:0015232) |
| 2.1 | 30.8 | GO:0043274 | phospholipase binding(GO:0043274) |
| 2.0 | 16.2 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 2.0 | 31.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 2.0 | 15.7 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 1.9 | 9.7 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 1.9 | 17.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.9 | 91.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 1.9 | 42.6 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 1.8 | 20.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 1.8 | 8.9 | GO:0097016 | L27 domain binding(GO:0097016) |
| 1.7 | 20.6 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 1.7 | 6.9 | GO:0019976 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 1.7 | 11.6 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 1.6 | 6.4 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 1.6 | 9.6 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 1.6 | 14.0 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 1.6 | 184.6 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 1.5 | 18.1 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 1.5 | 12.0 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 1.5 | 29.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.5 | 41.3 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.5 | 17.5 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 1.4 | 56.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 1.4 | 12.9 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 1.4 | 7.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 1.4 | 29.5 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 1.4 | 16.8 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 1.4 | 67.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 1.4 | 8.3 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 1.4 | 144.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 1.4 | 6.8 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 1.3 | 14.8 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 1.3 | 81.1 | GO:0009055 | electron carrier activity(GO:0009055) |
| 1.3 | 24.8 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 1.3 | 10.4 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 1.3 | 24.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 1.3 | 12.8 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 1.3 | 12.8 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 1.3 | 5.1 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 1.3 | 41.5 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 1.2 | 19.9 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 1.2 | 71.5 | GO:0005507 | copper ion binding(GO:0005507) |
| 1.2 | 1730.4 | GO:0003723 | RNA binding(GO:0003723) |
| 1.2 | 13.9 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 1.1 | 2.3 | GO:0004040 | amidase activity(GO:0004040) glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 1.1 | 11.4 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 1.1 | 24.7 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 1.1 | 14.6 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 1.1 | 177.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 1.1 | 10.5 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 1.0 | 16.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 1.0 | 21.9 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 1.0 | 15.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 1.0 | 78.0 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 1.0 | 10.1 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 1.0 | 10.1 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 1.0 | 14.1 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 1.0 | 2.9 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.9 | 69.1 | GO:0004702 | receptor signaling protein serine/threonine kinase activity(GO:0004702) |
| 0.8 | 59.7 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.8 | 12.5 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.8 | 4.1 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.8 | 10.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.8 | 66.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.8 | 60.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.8 | 23.8 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.7 | 17.7 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.7 | 18.3 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.7 | 2.8 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.7 | 10.5 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.7 | 7.3 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.6 | 5.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.6 | 101.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.6 | 18.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.6 | 15.0 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.6 | 13.1 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.6 | 3.5 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.4 | 10.7 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.4 | 2.2 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.4 | 3.8 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.4 | 53.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 19.7 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.4 | 1.2 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.4 | 7.1 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.4 | 1.9 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.4 | 6.0 | GO:0016208 | AMP binding(GO:0016208) |
| 0.3 | 56.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.3 | 5.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.3 | 1.9 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.3 | 5.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.3 | 3.9 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.3 | 0.3 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.3 | 109.3 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.3 | 20.5 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 0.2 | 28.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 10.8 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.2 | 1.4 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.2 | 3.0 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.2 | 1.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 0.6 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 2.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 7.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 2.8 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.2 | 8.0 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 1.0 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.1 | 2.2 | GO:0043531 | ADP binding(GO:0043531) |
| 0.1 | 7.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 4.0 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.1 | 2.2 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.1 | 0.8 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.1 | 1.3 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 15.9 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 17.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 4.0 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 2.4 | GO:0042165 | neurotransmitter binding(GO:0042165) |
| 0.0 | 3.1 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 6.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 7.6 | GO:0015293 | symporter activity(GO:0015293) |
| 0.0 | 0.2 | GO:0009008 | DNA-methyltransferase activity(GO:0009008) |
| 0.0 | 2.4 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.3 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 2.5 | GO:0005125 | cytokine activity(GO:0005125) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 191.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 6.8 | 394.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 6.7 | 322.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 5.5 | 105.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 5.0 | 115.9 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 4.9 | 151.0 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 4.8 | 308.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 4.2 | 88.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 3.6 | 158.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 3.5 | 114.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 3.0 | 33.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 3.0 | 117.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 2.8 | 53.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 2.7 | 96.2 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 2.7 | 284.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.6 | 72.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 2.4 | 124.3 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 2.3 | 140.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 2.3 | 16.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 2.3 | 73.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 2.3 | 102.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 2.3 | 47.8 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 2.3 | 61.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 1.9 | 32.9 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 1.9 | 211.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.8 | 33.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 1.8 | 14.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.8 | 10.7 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 1.6 | 54.8 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 1.6 | 46.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 1.4 | 92.6 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 1.4 | 251.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.3 | 53.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.3 | 81.3 | PID E2F PATHWAY | E2F transcription factor network |
| 1.2 | 89.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 1.2 | 24.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 1.2 | 109.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.2 | 20.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 1.1 | 63.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 1.1 | 26.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 1.1 | 39.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 1.0 | 2.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.8 | 43.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.8 | 35.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.8 | 24.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.8 | 15.9 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.8 | 36.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.7 | 15.7 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.7 | 23.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.7 | 19.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.7 | 36.0 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.6 | 13.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.6 | 32.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.5 | 21.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.4 | 19.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.4 | 10.6 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.4 | 9.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.4 | 24.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.3 | 21.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 8.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 4.0 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 4.0 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 9.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 8.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 5.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 1.8 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 1.9 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 3.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 0.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 1.0 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.4 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.2 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.5 | 220.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 19.6 | 19.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 12.9 | 116.5 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 10.4 | 757.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 9.2 | 821.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 8.5 | 205.1 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 8.5 | 93.5 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 8.0 | 144.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 7.7 | 131.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 7.7 | 115.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 7.5 | 367.4 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 7.3 | 262.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 7.2 | 86.6 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 7.0 | 245.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 6.8 | 75.2 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 6.6 | 59.6 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 6.6 | 39.4 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 6.6 | 91.7 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 6.4 | 470.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 6.2 | 136.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 5.9 | 153.8 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 5.9 | 94.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 5.8 | 57.7 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 5.5 | 60.6 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 5.5 | 223.8 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 5.4 | 114.2 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 5.3 | 90.3 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 5.2 | 337.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 5.1 | 40.4 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 5.0 | 181.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 5.0 | 667.0 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 5.0 | 90.1 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 4.8 | 751.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 4.5 | 35.7 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 4.4 | 145.3 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 4.2 | 66.5 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 4.1 | 202.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 4.1 | 114.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 4.1 | 40.5 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 3.9 | 35.3 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 3.9 | 129.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 3.9 | 158.7 | REACTOME CHROMOSOME MAINTENANCE | Genes involved in Chromosome Maintenance |
| 3.8 | 49.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 3.5 | 49.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 3.4 | 20.5 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 3.4 | 53.9 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 3.3 | 76.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 3.2 | 6.4 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 3.1 | 34.1 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 2.9 | 87.4 | REACTOME SIGNALING BY WNT | Genes involved in Signaling by Wnt |
| 2.9 | 34.9 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 2.9 | 65.9 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 2.9 | 14.3 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 2.8 | 78.1 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 2.8 | 416.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.7 | 19.1 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 2.7 | 51.7 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 2.7 | 86.8 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 2.7 | 35.1 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 2.6 | 31.5 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 2.5 | 81.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 2.5 | 102.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 2.4 | 142.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 2.1 | 38.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 2.1 | 79.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 2.0 | 26.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 2.0 | 57.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 2.0 | 29.6 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |
| 1.9 | 19.0 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 1.8 | 44.1 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 1.8 | 23.0 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 1.7 | 52.0 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 1.6 | 49.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 1.6 | 19.0 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 1.5 | 34.7 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 1.5 | 17.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 1.4 | 39.2 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 1.4 | 30.7 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 1.4 | 89.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 1.4 | 27.0 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 1.3 | 26.7 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 1.2 | 29.6 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 1.2 | 39.2 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 1.2 | 18.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 1.2 | 24.0 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 1.1 | 63.1 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 1.1 | 9.0 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 1.1 | 87.2 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 1.0 | 16.2 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 1.0 | 17.5 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.9 | 23.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.9 | 33.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.8 | 36.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.8 | 6.3 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.8 | 43.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.8 | 45.4 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.7 | 11.3 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.5 | 12.0 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.5 | 30.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.4 | 15.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.4 | 3.2 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.4 | 16.2 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.3 | 11.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.3 | 7.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 9.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.3 | 23.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 11.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.3 | 6.9 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.3 | 5.1 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.2 | 8.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 7.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 15.7 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.2 | 1.5 | REACTOME RNA POL III TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
| 0.2 | 32.0 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.1 | 1.8 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 6.4 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 1.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 3.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 6.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.2 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.2 | REACTOME SIGNALING BY FGFR1 MUTANTS | Genes involved in Signaling by FGFR1 mutants |