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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TBP

Z-value: 4.82

Motif logo

Transcription factors associated with TBP

Gene Symbol Gene ID Gene Info
ENSG00000112592.14 TBP

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBPhg38_v1_chr6_+_170554333_170554396-0.341.8e-07Click!

Activity profile of TBP motif

Sorted Z-values of TBP motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBP

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr12_-_91146195 72.82 ENST00000548218.1
decorin
chr11_-_5227063 60.99 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
hemoglobin subunit beta
chr1_-_58577244 50.06 ENST00000371225.4
tumor associated calcium signal transducer 2
chr16_+_56651885 46.98 ENST00000334346.3
ENST00000562399.1
metallothionein 1B
chr19_-_6720641 44.80 ENST00000245907.11
complement C3
chr5_-_42811884 44.61 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
selenoprotein P
chr16_+_56625775 38.22 ENST00000330439.7
ENST00000568293.1
metallothionein 1E
chr20_-_45254556 35.94 ENST00000338380.2
secretory leukocyte peptidase inhibitor
chr12_-_14885845 35.39 ENST00000539261.6
ENST00000228938.5
matrix Gla protein
chr11_-_5234475 30.35 ENST00000292901.7
ENST00000650601.1
ENST00000417377.1
hemoglobin subunit delta
chr21_-_26845402 29.40 ENST00000284984.8
ENST00000676955.1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr10_-_93601228 28.61 ENST00000371464.8
retinol binding protein 4
chr1_-_9943314 28.05 ENST00000377223.6
ENST00000377213.1
leucine zipper and CTNNBIP1 domain containing
chr6_+_31815532 27.27 ENST00000375651.7
ENST00000608703.1
heat shock protein family A (Hsp70) member 1A
chr11_-_5254741 27.22 ENST00000444587.1
ENST00000336906.6
ENST00000642908.1
ENST00000647543.1
hemoglobin subunit gamma 2
novel protein
chr11_-_5249836 27.20 ENST00000632727.1
ENST00000330597.5
hemoglobin subunit gamma 1
chr9_+_128149447 26.58 ENST00000277480.7
ENST00000372998.1
lipocalin 2
chr8_-_27614681 26.01 ENST00000519472.5
ENST00000523589.5
ENST00000522413.5
ENST00000523396.1
ENST00000316403.15
clusterin
chr1_-_94541746 25.48 ENST00000334047.12
coagulation factor III, tissue factor
chr12_-_53220229 24.49 ENST00000338561.9
retinoic acid receptor gamma
chr1_-_94541636 24.25 ENST00000370207.4
coagulation factor III, tissue factor
chr1_+_153357846 23.86 ENST00000368738.4
S100 calcium binding protein A9
chr10_+_7703340 23.75 ENST00000429820.5
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_88952763 23.48 ENST00000224784.10
actin alpha 2, smooth muscle
chr6_-_52995170 23.31 ENST00000370959.1
ENST00000370963.9
glutathione S-transferase alpha 4
chr1_-_182391783 23.13 ENST00000331872.11
ENST00000339526.8
glutamate-ammonia ligase
chr7_+_76302665 23.12 ENST00000248553.7
ENST00000674638.1
ENST00000674547.1
ENST00000675226.1
ENST00000675538.1
ENST00000676231.1
ENST00000675134.1
ENST00000675906.1
ENST00000674650.1
heat shock protein family B (small) member 1
chr11_+_45146631 22.76 ENST00000534751.3
ENST00000683152.1
PR/SET domain 11
chr1_-_230714112 22.40 ENST00000681514.1
ENST00000366667.6
ENST00000680041.1
angiotensinogen
chr7_+_143132069 21.70 ENST00000291009.4
prolactin induced protein
chr1_+_85580751 21.61 ENST00000451137.7
cellular communication network factor 1
chr10_+_7703300 21.22 ENST00000358415.9
inter-alpha-trypsin inhibitor heavy chain 2
chr19_-_35757009 21.18 ENST00000587965.1
ENST00000004982.6
heat shock protein family B (small) member 6
chr1_-_182391363 21.04 ENST00000417584.6
glutamate-ammonia ligase
chr16_-_56668034 21.00 ENST00000569500.5
ENST00000379811.4
ENST00000444837.6
metallothionein 1G
chr1_-_182391323 20.90 ENST00000642379.1
glutamate-ammonia ligase
chr12_+_123671105 20.53 ENST00000680574.1
ENST00000426174.6
ENST00000679504.1
ENST00000303372.7
tectonic family member 2
chr16_+_56669807 20.51 ENST00000332374.5
metallothionein 1H
chr17_-_50201618 19.57 ENST00000225964.10
collagen type I alpha 1 chain
chr7_-_100428657 19.50 ENST00000360951.8
ENST00000398027.6
ENST00000684423.1
ENST00000472716.1
zinc finger CW-type and PWWP domain containing 1
chr12_-_11310420 19.23 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
proline rich protein BstNI subfamily 4
chr18_+_24139053 19.22 ENST00000463087.5
ENST00000585037.5
ENST00000399496.8
ENST00000486759.6
ENST00000577705.1
ENST00000415309.6
ENST00000621648.4
ENST00000581397.5
calcium binding tyrosine phosphorylation regulated
chr1_+_159587817 19.12 ENST00000255040.3
amyloid P component, serum
chr1_-_153041111 19.11 ENST00000360379.4
small proline rich protein 2D
chr17_+_58238426 18.95 ENST00000421678.6
ENST00000262290.9
ENST00000543544.5
lactoperoxidase
chr12_-_11269696 18.84 ENST00000381842.7
proline rich protein BstNI subfamily 3
chr4_-_74099187 18.63 ENST00000508487.3
C-X-C motif chemokine ligand 2
chr6_+_27133032 17.86 ENST00000359193.3
H2A clustered histone 11
chrX_-_119943732 17.66 ENST00000371410.5
NFKB activating protein
chr20_+_31605280 17.49 ENST00000376105.4
ENST00000376112.4
inhibitor of DNA binding 1, HLH protein
chr10_+_87659839 17.43 ENST00000456849.2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr18_+_24139013 17.42 ENST00000399481.6
ENST00000327201.10
calcium binding tyrosine phosphorylation regulated
chr3_-_195583931 17.33 ENST00000343267.8
ENST00000421243.5
ENST00000453131.1
apolipoprotein D
chr16_+_56682461 17.21 ENST00000562939.1
ENST00000394485.5
ENST00000567563.1
metallothionein 1X
novel transcript
chr11_-_18248662 17.08 ENST00000256733.9
serum amyloid A2
chr6_-_27893175 17.01 ENST00000359611.4
H2A clustered histone 17
chr17_-_76710955 16.75 ENST00000355797.7
ENST00000449428.7
ENST00000375036.6
matrix remodeling associated 7
chr5_+_40909490 16.70 ENST00000313164.10
complement C7
chr10_-_122845850 16.60 ENST00000392790.6
CUB and zona pellucida like domains 1
chr17_-_50468871 16.11 ENST00000508540.6
ENST00000258969.4
chondroadherin
chr2_-_21044063 15.95 ENST00000233242.5
apolipoprotein B
chr16_+_152638 15.95 ENST00000252951.3
hemoglobin subunit zeta
chr12_-_11269805 15.82 ENST00000538488.2
proline rich protein BstNI subfamily 3
chr13_+_53028806 15.82 ENST00000219022.3
olfactomedin 4
chr8_-_6877928 15.79 ENST00000297439.4
defensin beta 1
chr4_+_73869385 15.53 ENST00000395761.4
C-X-C motif chemokine ligand 1
chr17_+_16380854 15.05 ENST00000577640.1
ubiquitin B
chr20_+_33235987 14.90 ENST00000375422.6
ENST00000375413.8
ENST00000354297.9
BPI fold containing family A member 1
chr1_+_207053229 14.71 ENST00000367080.8
ENST00000367079.3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr17_+_34319427 14.51 ENST00000394620.2
C-C motif chemokine ligand 8
chr22_-_31346143 14.48 ENST00000405309.7
ENST00000351933.8
POZ/BTB and AT hook containing zinc finger 1
chr12_-_53220377 14.41 ENST00000543726.1
retinoic acid receptor gamma
chr11_-_18248632 14.40 ENST00000524555.3
ENST00000528349.5
ENST00000526900.1
ENST00000529528.5
ENST00000414546.6
SAA2-SAA4 readthrough
serum amyloid A2
chr17_-_63918817 14.25 ENST00000458650.6
ENST00000351388.8
ENST00000342364.8
ENST00000617086.1
ENST00000323322.10
ENST00000392824.8
growth hormone 1
chorionic somatomammotropin hormone like 1
chr7_+_116953306 14.19 ENST00000265437.9
ENST00000393451.7
suppression of tumorigenicity 7
chr5_+_79111802 14.03 ENST00000524080.1
ENST00000274353.10
betaine--homocysteine S-methyltransferase
chr1_-_207052980 14.03 ENST00000367084.1
YOD1 deubiquitinase
chr3_+_101849505 13.82 ENST00000326151.9
ENST00000326172.9
NFKB inhibitor zeta
chr3_+_194136138 13.80 ENST00000232424.4
hes family bHLH transcription factor 1
chr1_+_152663378 13.75 ENST00000368784.2
late cornified envelope 2D
chr2_-_162152404 13.74 ENST00000375497.3
glucagon
chr19_+_10271093 13.65 ENST00000423829.2
ENST00000588645.1
ENST00000264832.8
intercellular adhesion molecule 1
chr6_-_169250825 13.43 ENST00000676869.1
ENST00000676760.1
thrombospondin 2
chr12_-_52493250 13.31 ENST00000330722.7
keratin 6A
chr8_-_7018295 13.21 ENST00000327857.7
defensin alpha 3
chr14_+_92923143 13.08 ENST00000216492.10
ENST00000334654.4
chromogranin A
chr1_-_153390976 12.70 ENST00000368732.5
ENST00000368733.4
S100 calcium binding protein A8
chr17_-_41505597 12.68 ENST00000336861.7
ENST00000246635.8
ENST00000587544.5
ENST00000587435.1
keratin 13
chr1_-_206117386 12.58 ENST00000367126.5
arginine vasopressin receptor 1B
chr9_-_21077938 12.48 ENST00000380232.4
interferon beta 1
chr17_-_41624541 12.43 ENST00000540235.5
ENST00000311208.13
keratin 17
chr11_+_18266254 12.42 ENST00000532858.5
ENST00000649195.1
ENST00000356524.9
ENST00000405158.2
serum amyloid A1
chr20_-_49278416 12.38 ENST00000371754.8
zinc finger NFX1-type containing 1
chr4_-_74038681 12.35 ENST00000296026.4
C-X-C motif chemokine ligand 3
chr6_-_26043704 12.28 ENST00000615966.2
H2B clustered histone 3
chr14_+_64540734 12.24 ENST00000247207.7
heat shock protein family A (Hsp70) member 2
chr17_+_81035122 12.21 ENST00000321280.11
ENST00000575989.5
ENST00000428708.7
ENST00000575712.5
ENST00000575245.5
ENST00000435091.7
ENST00000321300.10
BAR/IMD domain containing adaptor protein 2
chr6_-_33271835 12.08 ENST00000482399.5
ENST00000445902.3
VPS52 subunit of GARP complex
chr16_+_75222609 12.02 ENST00000495583.1
chymotrypsinogen B1
chr19_-_10836273 11.98 ENST00000591695.5
transmembrane p24 trafficking protein 1
chr1_+_152908538 11.97 ENST00000368764.4
involucrin
chr11_-_116837586 11.95 ENST00000375320.5
ENST00000359492.6
ENST00000375329.6
ENST00000375323.5
ENST00000236850.5
apolipoprotein A1
chr3_+_149474688 11.90 ENST00000305354.5
ENST00000465758.1
transmembrane 4 L six family member 4
chr12_-_52473798 11.81 ENST00000252250.7
keratin 6C
chr19_+_859654 11.78 ENST00000592860.2
ENST00000327726.11
complement factor D
chrX_+_85244075 11.69 ENST00000276123.7
zinc finger protein 711
chr19_+_8364146 11.48 ENST00000301455.7
ENST00000393962.6
angiopoietin like 4
chr2_-_162152239 11.27 ENST00000418842.7
glucagon
chr9_-_33447553 11.27 ENST00000645858.1
ENST00000297991.6
aquaporin 3 (Gill blood group)
chr1_-_216805367 11.23 ENST00000360012.7
estrogen related receptor gamma
chr3_-_194369731 11.21 ENST00000428839.1
ENST00000347624.4
leucine rich repeat containing 15
chrX_+_85244032 11.19 ENST00000373165.7
zinc finger protein 711
chr4_+_20251896 11.08 ENST00000504154.6
slit guidance ligand 2
chr6_+_27838600 10.94 ENST00000606613.1
H2B clustered histone 15
chr19_-_45322867 10.91 ENST00000221476.4
creatine kinase, M-type
chr8_-_133297092 10.85 ENST00000522890.5
ENST00000675983.1
ENST00000518176.5
ENST00000323851.13
ENST00000522476.5
ENST00000518066.5
ENST00000521544.5
ENST00000674605.1
ENST00000518480.5
ENST00000523892.5
N-myc downstream regulated 1
chr11_+_1697195 10.84 ENST00000382160.1
keratin associated protein 5-6
chr8_-_56074144 10.77 ENST00000618656.2
ribosomal protein S20
chr16_+_82035245 10.76 ENST00000199936.9
hydroxysteroid 17-beta dehydrogenase 2
chr1_-_11847772 10.73 ENST00000376480.7
ENST00000610706.1
natriuretic peptide A
chr12_-_52618559 10.69 ENST00000305748.7
keratin 73
chr17_-_63896568 10.63 ENST00000610991.1
ENST00000316193.13
ENST00000329882.8
chorionic somatomammotropin hormone 1
chr16_+_67807082 10.53 ENST00000567852.5
ENST00000565148.5
ENST00000388833.7
ENST00000561654.5
ENST00000431934.2
translin associated factor X interacting protein 1
chr17_-_63896621 10.41 ENST00000453363.7
chorionic somatomammotropin hormone 1
chr19_-_10836195 10.41 ENST00000589638.1
ENST00000214869.7
transmembrane p24 trafficking protein 1
chr6_+_7726089 10.38 ENST00000283147.7
bone morphogenetic protein 6
chr17_+_34356472 10.35 ENST00000225844.7
C-C motif chemokine ligand 13
chr7_+_143316105 10.31 ENST00000343257.7
ENST00000650516.1
chloride voltage-gated channel 1
chr17_-_63873676 10.30 ENST00000613718.3
ENST00000392886.7
ENST00000345366.8
ENST00000336844.9
ENST00000560142.5
chorionic somatomammotropin hormone 2
chr9_-_101435760 10.25 ENST00000647789.2
ENST00000616752.1
aldolase, fructose-bisphosphate B
chr17_-_41518878 10.22 ENST00000254043.8
keratin 15
chr8_+_22565655 10.19 ENST00000523965.5
sorbin and SH3 domain containing 3
chrX_+_141589700 10.16 ENST00000370518.4
SPANX family member A2
chr10_+_122560639 10.10 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
deleted in malignant brain tumors 1
chr3_+_148827800 10.09 ENST00000282957.9
ENST00000468341.1
carboxypeptidase B1
chr1_-_161223408 10.08 ENST00000491350.1
apolipoprotein A2
chr5_+_66958870 10.02 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
microtubule associated serine/threonine kinase family member 4
chr17_-_63911236 10.01 ENST00000438387.6
ENST00000346606.10
ENST00000309894.6
ENST00000561003.5
ENST00000450719.3
ENST00000259003.14
chorionic somatomammotropin hormone like 1
chr10_+_122560679 10.00 ENST00000657942.1
deleted in malignant brain tumors 1
chr21_-_42315336 9.97 ENST00000398431.2
ENST00000518498.3
trefoil factor 3
chr22_+_39520553 9.86 ENST00000674920.3
ENST00000679776.1
ENST00000675582.2
ENST00000337304.2
ENST00000676346.2
ENST00000396680.3
ENST00000680446.1
ENST00000674568.2
ENST00000680748.1
ENST00000674835.2
activating transcription factor 4
chr18_+_59220149 9.86 ENST00000256857.7
ENST00000529320.2
ENST00000420468.6
gastrin releasing peptide
chr7_+_73328152 9.84 ENST00000252037.5
ENST00000431982.6
FKBP prolyl isomerase family member 6 (inactive)
chr8_-_132085655 9.82 ENST00000262283.5
novel protein
chr7_+_73328177 9.75 ENST00000442793.5
ENST00000413573.6
FKBP prolyl isomerase family member 6 (inactive)
chr10_+_122560751 9.59 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
deleted in malignant brain tumors 1
chr10_+_52314272 9.53 ENST00000373970.4
dickkopf WNT signaling pathway inhibitor 1
chr6_-_27132750 9.50 ENST00000607124.1
ENST00000339812.3
H2B clustered histone 11
chr7_+_24284181 9.49 ENST00000407573.5
ENST00000242152.7
neuropeptide Y
chr19_+_8321487 9.48 ENST00000600659.3
ribosomal protein S28
chr11_-_2161158 9.36 ENST00000421783.1
ENST00000397262.5
ENST00000381330.5
ENST00000250971.7
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr6_+_82364234 9.33 ENST00000543496.3
trophoblast glycoprotein
chr6_-_26246996 9.31 ENST00000611444.2
H4 clustered histone 7
chr1_+_153031195 9.25 ENST00000307098.5
small proline rich protein 1B
chr19_+_35282520 9.24 ENST00000222304.5
hepcidin antimicrobial peptide
chrX_+_21855987 9.16 ENST00000429584.3
YY2 transcription factor
chr10_-_50885619 9.10 ENST00000373997.8
APOBEC1 complementation factor
chr12_-_10884244 9.08 ENST00000543626.4
proline rich protein HaeIII subfamily 1
chr1_-_203186677 9.03 ENST00000255409.8
chitinase 3 like 1
chr19_+_14028148 8.89 ENST00000431365.3
ENST00000585987.1
relaxin 3
chr6_+_26124161 8.88 ENST00000377791.4
ENST00000602637.1
H2A clustered histone 6
chr15_-_63381835 8.88 ENST00000344366.7
ENST00000178638.8
ENST00000422263.2
carbonic anhydrase 12
chr6_-_52994248 8.88 ENST00000457564.1
ENST00000370960.5
glutathione S-transferase alpha 4
chr22_+_24806265 8.82 ENST00000400359.4
small G protein signaling modulator 1
chr12_+_130162456 8.79 ENST00000539839.1
ENST00000229030.5
frizzled class receptor 10
chr20_+_23035312 8.72 ENST00000255008.5
somatostatin receptor 4
chrX_-_7927701 8.68 ENST00000537427.5
ENST00000444736.5
ENST00000442940.1
patatin like phospholipase domain containing 4
chr6_-_41747390 8.63 ENST00000356667.8
ENST00000373025.7
ENST00000425343.6
progastricsin
chr4_+_25655822 8.57 ENST00000504570.5
ENST00000382051.8
solute carrier family 34 member 2
chr17_+_16381083 8.51 ENST00000535788.1
ENST00000302182.8
ubiquitin B
chr1_-_117210918 8.35 ENST00000369458.8
ENST00000430871.3
ENST00000328189.7
V-set domain containing T cell activation inhibitor 1
chr21_+_25639251 8.35 ENST00000480456.6
junctional adhesion molecule 2
chr19_+_3933059 8.33 ENST00000616156.4
ENST00000168977.6
ENST00000599576.5
nicotinamide riboside kinase 2
chr4_+_70028452 8.32 ENST00000530128.5
ENST00000381057.3
ENST00000673563.1
histatin 3
chrX_+_153781033 8.24 ENST00000370104.5
ENST00000370108.7
ENST00000370101.8
ENST00000430541.5
ENST00000370100.5
SRSF protein kinase 3
chr1_-_156705764 8.21 ENST00000621784.4
ENST00000368220.1
cellular retinoic acid binding protein 2
chr6_-_26189101 8.20 ENST00000614247.2
H4 clustered histone 4
chr1_+_37474572 8.18 ENST00000373087.7
zinc finger CCCH-type containing 12A
chr9_+_134880806 8.16 ENST00000291744.11
ENST00000350339.3
ficolin 2
chrX_+_85243983 8.11 ENST00000674551.1
zinc finger protein 711
chr12_-_118359105 8.10 ENST00000541186.5
ENST00000539872.5
TAO kinase 3
chr5_+_80035341 8.09 ENST00000350881.6
thrombospondin 4
chr1_-_161223559 8.07 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
apolipoprotein A2
chr12_-_52452139 7.90 ENST00000252252.4
keratin 6B
chr1_+_12857086 7.70 ENST00000240189.2
PRAME family member 2
chr15_+_84981981 7.65 ENST00000339708.9
phosphodiesterase 8A
chr10_+_116545907 7.57 ENST00000369221.2
pancreatic lipase
chr9_+_133061981 7.52 ENST00000372080.8
carboxyl ester lipase
chr5_-_139198358 7.52 ENST00000394817.7
SIL1 nucleotide exchange factor
chr20_+_38304149 7.42 ENST00000262865.9
ENST00000642449.2
bactericidal permeability increasing protein
chr12_+_101594849 7.38 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
myosin binding protein C1
chr19_-_40882226 7.36 ENST00000301146.9
cytochrome P450 family 2 subfamily A member 7
chr1_-_42958836 7.31 ENST00000372500.4
ENST00000674765.1
ENST00000460369.3
ENST00000426263.10
solute carrier family 2 member 1
chr21_-_42366525 7.27 ENST00000291527.3
trefoil factor 1
chr6_-_27872334 7.27 ENST00000616365.2
H3 clustered histone 11
chr1_+_103655760 7.23 ENST00000370083.9
amylase alpha 1A
chr6_-_27838362 7.23 ENST00000618958.2
H2A clustered histone 15
chr9_+_89605004 7.19 ENST00000252506.11
ENST00000375769.1
growth arrest and DNA damage inducible gamma
chr5_-_54310545 7.16 ENST00000504924.6
ENST00000620747.4
ENST00000507646.2
ENST00000502271.5
ADP ribosylation factor like GTPase 15
chr19_+_3933581 7.13 ENST00000593949.1
nicotinamide riboside kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.3 61.0 GO:0030185 nitric oxide transport(GO:0030185)
16.3 65.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
16.1 16.1 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
14.9 44.8 GO:0001796 type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892)
12.4 49.7 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
10.3 10.3 GO:1905237 response to cyclosporin A(GO:1905237)
9.7 38.9 GO:0003431 growth plate cartilage chondrocyte growth(GO:0003430) growth plate cartilage chondrocyte development(GO:0003431)
9.5 9.5 GO:0003129 heart induction(GO:0003129)
7.5 22.4 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
7.2 50.1 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
6.9 13.8 GO:0045168 cell-cell signaling involved in cell fate commitment(GO:0045168)
6.8 27.3 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
6.4 19.1 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
6.3 25.0 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
6.0 30.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
6.0 143.9 GO:0071294 cellular response to zinc ion(GO:0071294)
5.9 105.3 GO:0015671 oxygen transport(GO:0015671)
5.8 17.4 GO:0000103 sulfate assimilation(GO:0000103)
5.8 23.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
5.8 17.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
5.6 72.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
5.6 28.0 GO:0090131 mesenchyme migration(GO:0090131)
5.3 26.6 GO:0010046 response to mycotoxin(GO:0010046) iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
5.3 15.8 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
5.2 26.0 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
4.9 19.6 GO:1902617 response to fluoride(GO:1902617)
4.8 28.6 GO:0048807 female genitalia morphogenesis(GO:0048807)
4.7 14.0 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
4.6 9.2 GO:1903413 cellular response to bile acid(GO:1903413)
4.6 22.9 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
4.5 35.8 GO:0001887 selenium compound metabolic process(GO:0001887)
4.4 13.3 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
4.0 15.9 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
3.7 14.9 GO:1900228 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
3.7 11.1 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
3.6 10.9 GO:0001207 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
3.5 17.5 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
3.5 10.4 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
3.5 17.3 GO:0007621 negative regulation of female receptivity(GO:0007621)
3.3 30.0 GO:1902255 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) fat pad development(GO:0060613) positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) positive regulation of protein monoubiquitination(GO:1902527)
3.3 9.9 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
3.1 6.3 GO:0002125 maternal aggressive behavior(GO:0002125)
3.1 9.4 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
3.1 9.3 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
3.0 12.0 GO:0018199 peptidyl-glutamine modification(GO:0018199)
2.8 11.3 GO:0070295 renal water absorption(GO:0070295)
2.8 19.6 GO:0034587 piRNA metabolic process(GO:0034587)
2.8 5.6 GO:0046878 positive regulation of saliva secretion(GO:0046878)
2.8 16.6 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
2.7 16.5 GO:0034371 chylomicron remodeling(GO:0034371)
2.7 13.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
2.7 8.2 GO:0010587 miRNA catabolic process(GO:0010587)
2.7 29.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
2.7 8.1 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
2.5 12.6 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
2.5 7.5 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
2.5 14.8 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
2.5 14.7 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
2.4 9.5 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
2.3 57.3 GO:0019731 antibacterial humoral response(GO:0019731)
2.3 43.0 GO:0003351 epithelial cilium movement(GO:0003351)
2.3 15.8 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
2.1 8.4 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
2.0 6.1 GO:0097026 dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
2.0 14.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
2.0 58.5 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
2.0 5.9 GO:0006533 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
1.9 5.8 GO:0015847 putrescine transport(GO:0015847)
1.9 5.7 GO:0001983 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
1.9 5.6 GO:0003218 cardiac left ventricle formation(GO:0003218)
1.8 19.7 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
1.8 10.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.7 12.2 GO:1905232 cellular response to L-glutamate(GO:1905232)
1.7 8.7 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
1.7 10.4 GO:0060356 leucine import(GO:0060356)
1.7 66.9 GO:0018149 peptide cross-linking(GO:0018149)
1.7 10.3 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
1.7 20.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.7 8.4 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.6 6.6 GO:0035962 response to interleukin-13(GO:0035962)
1.6 14.7 GO:0097267 omega-hydroxylase P450 pathway(GO:0097267)
1.6 29.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
1.6 4.7 GO:0035993 subthalamic nucleus development(GO:0021763) deltoid tuberosity development(GO:0035993) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
1.6 40.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
1.6 12.5 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
1.6 10.9 GO:0006600 creatine metabolic process(GO:0006600)
1.5 6.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
1.5 9.1 GO:0016554 cytidine to uridine editing(GO:0016554)
1.5 6.0 GO:0035106 operant conditioning(GO:0035106)
1.5 4.4 GO:0060032 notochord regression(GO:0060032)
1.4 11.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
1.4 4.3 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
1.4 28.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.4 5.6 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.4 4.1 GO:0015669 gas transport(GO:0015669)
1.4 4.1 GO:0035425 autocrine signaling(GO:0035425)
1.4 13.6 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
1.4 9.5 GO:0032097 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
1.4 6.8 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
1.3 9.2 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.3 1.3 GO:1904437 positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
1.3 2.6 GO:0051097 negative regulation of helicase activity(GO:0051097)
1.3 3.8 GO:2000848 positive regulation of corticosteroid hormone secretion(GO:2000848)
1.3 8.9 GO:0055064 chloride ion homeostasis(GO:0055064)
1.3 2.5 GO:0014806 smooth muscle hyperplasia(GO:0014806)
1.3 6.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
1.2 4.9 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
1.2 35.4 GO:0001502 cartilage condensation(GO:0001502)
1.2 5.8 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.2 12.7 GO:0043587 tongue morphogenesis(GO:0043587)
1.1 50.2 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
1.1 29.3 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
1.1 8.8 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
1.1 4.4 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
1.1 5.4 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
1.0 3.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
1.0 32.2 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
1.0 4.1 GO:0033693 neurofilament bundle assembly(GO:0033693)
1.0 12.1 GO:0010668 ectodermal cell differentiation(GO:0010668)
1.0 10.8 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
1.0 3.9 GO:0046968 peptide antigen transport(GO:0046968)
1.0 13.8 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.0 17.5 GO:0045109 intermediate filament organization(GO:0045109)
1.0 6.8 GO:0042483 negative regulation of odontogenesis(GO:0042483)
1.0 3.8 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.9 12.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.9 2.7 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.9 15.4 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.9 3.4 GO:0002357 defense response to tumor cell(GO:0002357)
0.9 33.3 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.8 2.5 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.8 9.0 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.8 19.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.8 3.2 GO:0070092 glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.8 7.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.8 3.9 GO:0032667 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.8 23.8 GO:0042572 retinol metabolic process(GO:0042572)
0.8 10.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.7 12.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.7 41.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.7 7.9 GO:0007398 ectoderm development(GO:0007398)
0.7 1.4 GO:0071288 cellular response to mercury ion(GO:0071288)
0.7 10.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.6 2.6 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.6 3.8 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.6 12.0 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.6 4.4 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.6 49.1 GO:0070268 cornification(GO:0070268)
0.6 4.2 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.6 16.8 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.6 4.1 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.6 4.1 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.6 5.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.5 2.7 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.5 5.8 GO:0030728 ovulation(GO:0030728)
0.5 17.7 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.5 2.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.5 1.0 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693)
0.5 29.5 GO:0006953 acute-phase response(GO:0006953)
0.5 2.4 GO:0035900 response to isolation stress(GO:0035900)
0.5 7.8 GO:0031424 keratinization(GO:0031424)
0.5 1.8 GO:0000023 maltose metabolic process(GO:0000023)
0.5 1.4 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.5 11.0 GO:0019730 antimicrobial humoral response(GO:0019730)
0.4 6.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.4 6.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.4 12.0 GO:0009235 cobalamin metabolic process(GO:0009235)
0.4 9.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 2.0 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.4 1.5 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.4 1.1 GO:0021780 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 1.4 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.3 1.7 GO:2000858 mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) regulation of aldosterone secretion(GO:2000858)
0.3 1.9 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.3 4.4 GO:0003334 keratinocyte development(GO:0003334)
0.3 6.8 GO:0032486 Rap protein signal transduction(GO:0032486)
0.3 1.8 GO:0001692 histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.3 5.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.3 2.3 GO:0007028 cytoplasm organization(GO:0007028)
0.3 0.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 9.2 GO:0034694 response to prostaglandin(GO:0034694)
0.2 11.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 23.8 GO:0007586 digestion(GO:0007586)
0.2 1.1 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 5.3 GO:1903206 negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.2 4.8 GO:0007530 sex determination(GO:0007530)
0.2 5.8 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.2 2.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 15.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 12.1 GO:0042246 tissue regeneration(GO:0042246)
0.2 6.6 GO:0040019 positive regulation of embryonic development(GO:0040019)
0.2 4.3 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.2 10.2 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.2 8.8 GO:2000273 positive regulation of receptor activity(GO:2000273)
0.2 11.5 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 5.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.2 15.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 2.7 GO:0072678 T cell migration(GO:0072678)
0.2 20.5 GO:0007224 smoothened signaling pathway(GO:0007224)
0.2 1.7 GO:0060992 response to fungicide(GO:0060992)
0.2 1.7 GO:0061635 regulation of protein complex stability(GO:0061635)
0.2 0.6 GO:0009305 protein biotinylation(GO:0009305) histone biotinylation(GO:0071110)
0.1 1.5 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.1 0.7 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 1.8 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 1.1 GO:0032119 sequestering of zinc ion(GO:0032119)
0.1 6.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 12.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 4.9 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 4.4 GO:0060325 face morphogenesis(GO:0060325)
0.1 10.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 0.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 2.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 17.0 GO:0010212 response to ionizing radiation(GO:0010212)
0.1 3.8 GO:0090303 positive regulation of wound healing(GO:0090303)
0.1 2.4 GO:0060384 response to histamine(GO:0034776) innervation(GO:0060384) cellular response to histamine(GO:0071420)
0.1 0.3 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.1 5.4 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 2.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 5.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 0.1 GO:0060300 regulation of cytokine activity(GO:0060300)
0.1 4.1 GO:0006400 tRNA modification(GO:0006400)
0.1 4.7 GO:0021549 cerebellum development(GO:0021549)
0.1 0.9 GO:0014911 positive regulation of smooth muscle cell migration(GO:0014911)
0.0 1.4 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 3.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.3 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.4 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 5.6 GO:0010952 positive regulation of peptidase activity(GO:0010952)
0.0 2.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 1.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 4.6 GO:0043542 endothelial cell migration(GO:0043542)
0.0 0.8 GO:0010039 response to iron ion(GO:0010039)
0.0 2.8 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 1.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 1.7 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 1.3 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 1.7 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 1.7 GO:0034332 adherens junction organization(GO:0034332)
0.0 2.3 GO:0009749 response to glucose(GO:0009749)
0.0 1.6 GO:0042445 hormone metabolic process(GO:0042445)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.2 61.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
14.3 43.0 GO:0097229 sperm end piece(GO:0097229)
8.1 105.3 GO:0005833 hemoglobin complex(GO:0005833)
7.8 23.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
5.6 72.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
5.1 15.4 GO:0070195 growth hormone receptor complex(GO:0070195)
4.0 44.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
4.0 27.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
2.6 49.8 GO:0042589 zymogen granule membrane(GO:0042589)
2.6 12.8 GO:0036128 CatSper complex(GO:0036128)
2.3 9.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
2.2 44.6 GO:0031089 platelet dense granule lumen(GO:0031089)
2.1 59.6 GO:0097386 glial cell projection(GO:0097386)
2.1 16.7 GO:0005579 membrane attack complex(GO:0005579)
2.0 9.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
1.8 44.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
1.8 79.1 GO:0045095 keratin filament(GO:0045095)
1.7 12.1 GO:1990745 EARP complex(GO:1990745)
1.5 49.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
1.5 19.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.5 68.4 GO:0001533 cornified envelope(GO:0001533)
1.3 15.3 GO:0097486 multivesicular body lumen(GO:0097486)
1.2 13.3 GO:0042583 chromaffin granule(GO:0042583)
1.2 8.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.2 9.2 GO:0045179 apical cortex(GO:0045179)
1.2 105.0 GO:0035580 specific granule lumen(GO:0035580)
1.1 20.5 GO:0036038 MKS complex(GO:0036038)
1.1 6.8 GO:0072687 meiotic spindle(GO:0072687)
1.1 4.4 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
1.0 7.3 GO:0001939 female pronucleus(GO:0001939)
1.0 50.1 GO:0009925 basal plasma membrane(GO:0009925)
1.0 17.5 GO:0097225 sperm midpiece(GO:0097225)
1.0 28.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.9 4.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.9 6.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.9 4.3 GO:0030314 junctional membrane complex(GO:0030314)
0.9 37.5 GO:0031904 endosome lumen(GO:0031904)
0.7 145.9 GO:0072562 blood microparticle(GO:0072562)
0.7 2.7 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.6 4.9 GO:0030057 desmosome(GO:0030057)
0.6 4.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.5 5.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.5 37.7 GO:0005882 intermediate filament(GO:0005882)
0.5 4.6 GO:0061574 ASAP complex(GO:0061574)
0.5 1.4 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.4 2.6 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.4 4.7 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.4 11.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.4 5.8 GO:0005916 fascia adherens(GO:0005916)
0.4 21.1 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.4 1.4 GO:0070876 SOSS complex(GO:0070876)
0.3 12.2 GO:0042629 mast cell granule(GO:0042629)
0.3 4.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.3 27.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.3 487.5 GO:0005615 extracellular space(GO:0005615)
0.3 2.4 GO:0005610 laminin-5 complex(GO:0005610)
0.3 10.3 GO:0034451 centriolar satellite(GO:0034451)
0.3 19.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 49.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 10.4 GO:0000795 synaptonemal complex(GO:0000795)
0.2 8.8 GO:0016592 mediator complex(GO:0016592)
0.2 0.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 5.4 GO:0005796 Golgi lumen(GO:0005796)
0.2 3.2 GO:0000786 nucleosome(GO:0000786)
0.2 11.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 12.1 GO:0005811 lipid particle(GO:0005811)
0.2 130.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 3.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 11.1 GO:0034707 chloride channel complex(GO:0034707)
0.1 4.4 GO:0097546 ciliary base(GO:0097546)
0.1 4.4 GO:0002102 podosome(GO:0002102)
0.1 0.6 GO:0005652 nuclear lamina(GO:0005652)
0.1 3.2 GO:0005921 gap junction(GO:0005921)
0.1 13.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 6.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 11.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.4 GO:0001772 immunological synapse(GO:0001772)
0.1 0.5 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 34.6 GO:0009986 cell surface(GO:0009986)
0.1 6.1 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.9 GO:0031526 brush border membrane(GO:0031526)
0.0 1.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.6 GO:0016459 myosin complex(GO:0016459)
0.0 3.7 GO:0030017 sarcomere(GO:0030017)
0.0 1.3 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
16.3 65.1 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
12.2 36.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
11.1 166.3 GO:0005344 oxygen transporter activity(GO:0005344)
9.9 29.7 GO:0035375 zymogen binding(GO:0035375)
7.7 23.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
6.0 30.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
5.3 15.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
4.9 19.8 GO:0035473 lipase binding(GO:0035473)
4.7 14.0 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
4.0 60.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
3.9 15.5 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
3.7 44.6 GO:0008430 selenium binding(GO:0008430)
3.6 10.8 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
3.6 14.2 GO:0005148 prolactin receptor binding(GO:0005148)
3.5 55.3 GO:0019841 retinol binding(GO:0019841)
3.4 10.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
3.4 10.3 GO:0061609 fructose-1-phosphate aldolase activity(GO:0061609)
2.8 11.3 GO:0015254 glycerol channel activity(GO:0015254)
2.7 18.8 GO:0001849 complement component C1q binding(GO:0001849)
2.7 10.7 GO:0045569 TRAIL binding(GO:0045569)
2.5 50.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
2.5 27.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
2.5 14.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
2.4 7.3 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
2.4 7.2 GO:0004556 alpha-amylase activity(GO:0004556)
2.3 11.5 GO:0004995 tachykinin receptor activity(GO:0004995)
2.3 11.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
2.0 14.0 GO:0008172 S-methyltransferase activity(GO:0008172)
2.0 5.9 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.9 5.8 GO:0015203 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
1.8 11.1 GO:0043237 laminin-1 binding(GO:0043237)
1.8 5.4 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
1.8 19.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.8 12.4 GO:0042289 MHC class II protein binding(GO:0042289)
1.8 8.8 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
1.7 8.7 GO:0004994 somatostatin receptor activity(GO:0004994)
1.7 5.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
1.6 6.6 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
1.6 6.3 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
1.6 12.6 GO:0005000 vasopressin receptor activity(GO:0005000)
1.5 7.5 GO:0004771 sterol esterase activity(GO:0004771)
1.5 43.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
1.4 5.7 GO:0031716 calcitonin receptor binding(GO:0031716)
1.4 35.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
1.4 10.9 GO:0004111 creatine kinase activity(GO:0004111)
1.2 3.7 GO:0008903 hydroxypyruvate isomerase activity(GO:0008903)
1.2 17.3 GO:0070324 thyroid hormone binding(GO:0070324)
1.2 155.6 GO:0005179 hormone activity(GO:0005179)
1.2 6.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
1.2 39.7 GO:0042056 chemoattractant activity(GO:0042056)
1.1 5.7 GO:0070097 delta-catenin binding(GO:0070097)
1.1 4.4 GO:0004668 protein-arginine deiminase activity(GO:0004668)
1.1 5.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.0 85.4 GO:0050840 extracellular matrix binding(GO:0050840)
1.0 12.5 GO:0016413 O-acetyltransferase activity(GO:0016413)
1.0 10.4 GO:0070700 BMP receptor binding(GO:0070700)
1.0 14.5 GO:0016004 phospholipase activator activity(GO:0016004)
1.0 7.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
1.0 17.2 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
1.0 4.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.0 7.8 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.0 8.6 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321) phosphate ion binding(GO:0042301)
0.9 22.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.9 6.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.9 25.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.8 4.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.8 9.0 GO:0008061 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.8 10.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.7 78.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.7 5.8 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.7 1.4 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.7 2.8 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.7 12.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.7 6.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.7 8.2 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.7 5.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.7 32.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 17.5 GO:0070628 proteasome binding(GO:0070628)
0.6 10.1 GO:0031432 titin binding(GO:0031432)
0.6 5.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.6 3.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.6 16.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.6 19.7 GO:0070566 adenylyltransferase activity(GO:0070566)
0.6 2.4 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.6 5.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.5 5.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.5 6.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 140.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 2.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.5 2.0 GO:0004461 lactose synthase activity(GO:0004461)
0.5 40.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 10.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 3.4 GO:0033691 sialic acid binding(GO:0033691)
0.5 1.4 GO:0005135 interleukin-3 receptor binding(GO:0005135)
0.5 1.8 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.4 56.5 GO:0008201 heparin binding(GO:0008201)
0.4 4.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.4 12.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.4 13.1 GO:0004601 peroxidase activity(GO:0004601)
0.4 1.6 GO:0042015 interleukin-20 binding(GO:0042015)
0.4 10.2 GO:0017166 vinculin binding(GO:0017166)
0.4 8.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.4 2.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.4 8.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 3.7 GO:0005549 odorant binding(GO:0005549)
0.3 4.1 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.3 10.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 17.8 GO:0015485 cholesterol binding(GO:0015485)
0.3 4.9 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.3 4.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 4.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 1.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.3 2.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 7.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.3 10.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 10.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 2.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 2.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.3 2.5 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.3 4.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 6.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 3.2 GO:0046870 cadmium ion binding(GO:0046870)
0.2 2.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.2 43.0 GO:0017124 SH3 domain binding(GO:0017124)
0.2 4.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 22.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 1.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 24.6 GO:0002020 protease binding(GO:0002020)
0.2 1.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 4.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 1.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974) histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 20.0 GO:0001618 virus receptor activity(GO:0001618)
0.2 8.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 1.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 21.0 GO:0008013 beta-catenin binding(GO:0008013)
0.2 5.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 4.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.2 17.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 4.3 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.2 4.7 GO:0030371 translation repressor activity(GO:0030371)
0.2 13.8 GO:0051087 chaperone binding(GO:0051087)
0.2 7.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 0.6 GO:0018271 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.1 2.0 GO:0043422 protein kinase B binding(GO:0043422)
0.1 5.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.4 GO:0030547 receptor inhibitor activity(GO:0030547)
0.1 110.4 GO:0008270 zinc ion binding(GO:0008270)
0.1 0.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.8 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 6.2 GO:0005518 collagen binding(GO:0005518)
0.1 1.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.1 1.3 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 5.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 10.7 GO:0019905 syntaxin binding(GO:0019905)
0.1 4.9 GO:0050681 androgen receptor binding(GO:0050681)
0.1 2.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 4.4 GO:0019003 GDP binding(GO:0019003)
0.1 4.5 GO:0017022 myosin binding(GO:0017022)
0.1 0.5 GO:0008312 7S RNA binding(GO:0008312)
0.1 45.3 GO:0005198 structural molecule activity(GO:0005198)
0.1 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.1 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.0 1.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 8.0 GO:0008168 methyltransferase activity(GO:0008168)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.0 3.6 GO:0005178 integrin binding(GO:0005178)
0.0 13.9 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 2.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 7.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.8 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 5.8 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 12.4 GO:0008289 lipid binding(GO:0008289)
0.0 3.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 136.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.6 44.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
1.4 49.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.4 5.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
1.0 56.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.9 12.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.8 42.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.8 19.6 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.7 28.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.7 28.3 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.6 18.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.6 44.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.5 18.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.5 18.9 PID IL3 PATHWAY IL3-mediated signaling events
0.5 11.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.5 171.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.4 23.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 16.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 115.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 10.7 PID TRAIL PATHWAY TRAIL signaling pathway
0.4 15.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.4 22.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 32.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.3 2.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 9.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.3 50.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 9.2 PID RAS PATHWAY Regulation of Ras family activation
0.2 5.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 13.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 10.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 12.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 10.7 PID AP1 PATHWAY AP-1 transcription factor network
0.2 7.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 10.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 35.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.2 11.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 3.9 PID CONE PATHWAY Visual signal transduction: Cones
0.2 19.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 4.7 ST ADRENERGIC Adrenergic Pathway
0.1 5.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 9.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 4.2 PID INSULIN PATHWAY Insulin Pathway
0.1 5.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 6.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.5 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.7 PID IL1 PATHWAY IL1-mediated signaling events
0.1 4.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 5.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 2.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.8 PID ATR PATHWAY ATR signaling pathway
0.0 1.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 53.7 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
2.7 72.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
2.4 67.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
2.2 41.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
2.1 46.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.6 15.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
1.5 33.7 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
1.4 55.4 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
1.3 21.5 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
1.2 21.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.2 13.2 REACTOME DEFENSINS Genes involved in Defensins
1.2 29.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
1.1 46.8 REACTOME AMYLOIDS Genes involved in Amyloids
1.0 12.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.9 32.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.9 12.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.8 14.7 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.8 159.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.8 12.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.8 17.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.7 16.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.7 106.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.6 67.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.6 23.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 7.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 11.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.4 2.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 33.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 3.7 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.3 2.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 4.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 13.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 2.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 2.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 5.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 10.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 10.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 4.9 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.2 7.6 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.2 7.7 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.2 11.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 15.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.2 4.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 9.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 6.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 6.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 5.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 7.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 0.8 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.1 8.0 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.1 5.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 8.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 4.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 3.7 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides