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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TBX20

Z-value: 3.18

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Transcription factors associated with TBX20

Gene Symbol Gene ID Gene Info
TBX20
ENSG00000164532.11 TBX20

Activity profile of TBX20 motif

Sorted Z-values of TBX20 motif

Network of associatons between targets according to the STRING database.

Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_57628684 300.35 ENST00000567397.5
ENST00000568979.5
ENST00000672974.1
ADGRG1
adhesion G protein-coupled receptor G1
chr16_+_57628507 118.26 ENST00000456916.5
ENST00000567154.5
ENST00000388813.9
ENST00000562558.6
ENST00000566271.6
ENST00000563374.5
ENST00000673126.2
ENST00000562631.7
ENST00000568234.5
ENST00000565770.5
ENST00000566164.5
ADGRG1
adhesion G protein-coupled receptor G1
chr3_-_131502946 16.95 ENST00000512877.1
ENST00000264995.8
ENST00000511168.5
ENST00000425847.6
MRPL3
mitochondrial ribosomal protein L3
chr12_-_55729660 15.75 ENST00000546457.1
ENST00000549117.5
CD63
CD63 molecule
chr6_-_2841853 12.48 ENST00000380739.6
SERPINB1
serpin family B member 1
chr15_-_84716063 12.06 ENST00000558217.5
ENST00000558196.1
ENST00000558134.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr15_-_84716099 11.90 ENST00000560266.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr15_-_84716153 11.61 ENST00000455959.7
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chrX_-_101617921 11.44 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr5_+_134525649 10.06 ENST00000282605.8
ENST00000681547.2
ENST00000361895.6
ENST00000402835.5
JADE2
jade family PHD finger 2
chr15_-_84716384 9.75 ENST00000559729.5
SEC11A
SEC11 homolog A, signal peptidase complex subunit
chr2_+_63840944 9.26 ENST00000484142.2
ENST00000482668.5
ENST00000467648.6
ENST00000394417.7
UGP2
UDP-glucose pyrophosphorylase 2
chr2_-_218269619 9.06 ENST00000447885.1
ENST00000420660.5
AAMP
angio associated migratory cell protein
chr2_+_63840982 8.77 ENST00000480679.5
ENST00000613823.2
ENST00000677841.1
UGP2
UDP-glucose pyrophosphorylase 2
chr11_-_14337074 7.69 ENST00000531421.5
RRAS2
RAS related 2
chr5_+_136059151 7.36 ENST00000503087.1
TGFBI
transforming growth factor beta induced
chr3_+_142596385 7.18 ENST00000457734.7
ENST00000483373.5
ENST00000475296.5
ENST00000495744.5
ENST00000476044.5
ENST00000461644.5
ENST00000464320.5
PLS1
plastin 1
chr8_-_108443409 6.99 ENST00000678023.1
ENST00000679198.1
ENST00000678881.1
ENST00000677084.1
ENST00000676663.1
ENST00000677614.1
ENST00000677040.1
ENST00000676487.1
ENST00000677409.1
ENST00000678797.1
ENST00000678334.1
EIF3E
eukaryotic translation initiation factor 3 subunit E
chr2_-_218270099 6.53 ENST00000248450.9
ENST00000444053.5
AAMP
angio associated migratory cell protein
chr16_+_31033513 6.15 ENST00000313843.8
STX4
syntaxin 4
chr1_-_11058839 5.99 ENST00000465788.1
SRM
spermidine synthase
chr1_+_87331668 5.28 ENST00000370542.1
LMO4
LIM domain only 4
chr1_-_17054015 4.65 ENST00000375499.8
SDHB
succinate dehydrogenase complex iron sulfur subunit B
chr22_-_42649332 4.14 ENST00000352397.10
CYB5R3
cytochrome b5 reductase 3
chr1_-_154936681 3.25 ENST00000368467.4
PMVK
phosphomevalonate kinase
chr1_+_147541491 3.06 ENST00000683836.1
ENST00000234739.8
BCL9
BCL9 transcription coactivator
chr14_-_106235582 1.98 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr15_-_74212219 1.73 ENST00000449139.6
STRA6
signaling receptor and transporter of retinol STRA6
chr3_-_139678011 1.66 ENST00000646611.1
ENST00000645290.1
ENST00000647257.1
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr15_-_74212256 1.63 ENST00000416286.7
STRA6
signaling receptor and transporter of retinol STRA6
chr22_+_37823382 1.61 ENST00000249041.3
GALR3
galanin receptor 3
chr10_-_102114935 1.39 ENST00000361198.9
LDB1
LIM domain binding 1
chr12_-_121038967 1.32 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr12_+_15322257 1.12 ENST00000674316.1
PTPRO
protein tyrosine phosphatase receptor type O
chr14_-_105987068 0.93 ENST00000390594.3
IGHV1-2
immunoglobulin heavy variable 1-2
chr12_-_121039156 0.93 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr15_-_21718245 0.84 ENST00000630556.1
ENSG00000281179.1
novel gene identicle to IGHV1OR15-1
chr1_-_158330957 0.58 ENST00000451207.5
CD1B
CD1b molecule
chr1_-_204307391 0.50 ENST00000637508.1
PLEKHA6
pleckstrin homology domain containing A6
chr12_+_15322480 0.33 ENST00000674188.1
ENST00000281171.9
ENST00000543886.6
PTPRO
protein tyrosine phosphatase receptor type O
chr1_+_162790702 0.27 ENST00000254521.8
ENST00000367915.1
HSD17B7
hydroxysteroid 17-beta dehydrogenase 7
chr12_-_121039236 0.09 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr3_-_50359480 0.09 ENST00000266025.4
TMEM115
transmembrane protein 115
chr12_-_121039204 0.01 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
32.2 418.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
3.0 18.0 GO:0019255 UDP-glucuronate biosynthetic process(GO:0006065) glucose 1-phosphate metabolic process(GO:0019255)
2.1 6.2 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
1.4 7.2 GO:1902896 terminal web assembly(GO:1902896)
1.4 41.5 GO:0006465 signal peptide processing(GO:0006465)
1.1 15.8 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
1.1 3.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.9 6.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.8 7.0 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.8 10.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.6 3.4 GO:0061143 alveolar primary septum development(GO:0061143)
0.5 1.4 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.4 5.3 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.2 0.9 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 17.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 4.6 GO:0006105 succinate metabolic process(GO:0006105)
0.2 4.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.2 15.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.6 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 3.1 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 5.7 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 12.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.6 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 2.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 7.7 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 1.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
59.8 418.6 GO:0097451 glial limiting end-foot(GO:0097451)
5.0 45.3 GO:0005787 signal peptidase complex(GO:0005787)
1.3 15.8 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.2 7.2 GO:1990357 terminal web(GO:1990357)
0.9 4.6 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.8 6.2 GO:0000322 storage vacuole(GO:0000322)
0.5 15.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.4 17.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 4.1 GO:0005833 hemoglobin complex(GO:0005833)
0.2 7.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 10.1 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 7.4 GO:0005604 basement membrane(GO:0005604)
0.0 3.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 12.5 GO:0034774 secretory granule lumen(GO:0034774)
0.0 3.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 426.0 GO:0050840 extracellular matrix binding(GO:0050840)
4.5 18.0 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
2.0 6.0 GO:0004766 spermidine synthase activity(GO:0004766)
1.5 6.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.2 4.6 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.4 4.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 1.6 GO:0004966 galanin receptor activity(GO:0004966)
0.2 2.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 1.4 GO:0030274 LIM domain binding(GO:0030274)
0.1 12.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 37.8 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 15.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 7.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 17.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.6 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 7.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.9 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 7.7 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 6.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 7.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 5.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 8.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 45.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.7 18.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 6.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 6.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 4.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 7.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 15.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 7.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling