Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for TBX4

Z-value: 2.40

Motif logo

Transcription factors associated with TBX4

Gene Symbol Gene ID Gene Info
ENSG00000121075.11 TBX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX4hg38_v1_chr17_+_61452378_614524370.275.9e-05Click!

Activity profile of TBX4 motif

Sorted Z-values of TBX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image
Promoter Score Transcript Gene Gene Info
chr3_+_167735704 20.31 ENST00000446050.7
ENST00000295777.9
ENST00000472747.2
serpin family I member 1
chr11_+_73647549 15.89 ENST00000227214.10
ENST00000398494.8
ENST00000543085.5
pleckstrin homology domain containing B1
chr2_-_175005357 14.52 ENST00000409156.7
ENST00000444573.2
ENST00000409900.9
chimerin 1
chr2_-_2326378 14.39 ENST00000647618.1
myelin transcription factor 1 like
chr20_+_46029165 9.50 ENST00000616201.4
ENST00000616202.4
ENST00000616933.4
ENST00000626937.2
solute carrier family 12 member 5
chr20_+_46029206 9.16 ENST00000243964.7
solute carrier family 12 member 5
chr13_-_35855627 8.23 ENST00000379893.5
doublecortin like kinase 1
chr5_+_75512058 6.86 ENST00000514296.5
DNA polymerase kappa
chr6_+_39792298 6.86 ENST00000633794.1
ENST00000274867.9
dishevelled associated activator of morphogenesis 2
chr2_+_102473219 6.40 ENST00000295269.5
solute carrier family 9 member A4
chr14_+_75280078 6.31 ENST00000555347.1
Fos proto-oncogene, AP-1 transcription factor subunit
chr14_+_75278820 5.97 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
Fos proto-oncogene, AP-1 transcription factor subunit
chrX_-_138711663 5.82 ENST00000315930.11
fibroblast growth factor 13
chr4_-_101347327 5.74 ENST00000394853.8
protein phosphatase 3 catalytic subunit alpha
chr15_-_82647336 5.68 ENST00000617522.4
ENST00000684509.1
cytoplasmic polyadenylation element binding protein 1
chr4_+_8580387 5.56 ENST00000382487.5
G protein-coupled receptor 78
chr15_-_82647503 5.45 ENST00000567678.1
ENST00000620182.4
cytoplasmic polyadenylation element binding protein 1
chr7_+_97732046 5.16 ENST00000350485.8
ENST00000346867.4
ENST00000319273.10
tachykinin precursor 1
chr13_-_35855758 5.06 ENST00000615680.4
doublecortin like kinase 1
chr4_-_101347492 4.71 ENST00000394854.8
protein phosphatase 3 catalytic subunit alpha
chr8_+_55102012 4.60 ENST00000327381.7
XK related 4
chr20_+_2536573 4.41 ENST00000358864.2
transmembrane channel like 2
chr12_-_89630552 4.34 ENST00000393164.6
ATPase plasma membrane Ca2+ transporting 1
chr3_+_63819341 4.32 ENST00000647022.1
chromosome 3 open reading frame 49
chr1_+_69567906 4.21 ENST00000651989.2
leucine rich repeat containing 7
chr7_-_72336995 4.19 ENST00000329008.9
calneuron 1
chr2_-_156332694 4.18 ENST00000424077.1
ENST00000426264.5
ENST00000421709.1
ENST00000339562.9
nuclear receptor subfamily 4 group A member 2
chr4_-_101347471 4.13 ENST00000323055.10
ENST00000512215.5
protein phosphatase 3 catalytic subunit alpha
chr1_+_145927105 3.72 ENST00000437797.5
ENST00000601726.3
ENST00000599626.5
ENST00000599147.5
ENST00000595494.5
ENST00000595518.5
ENST00000597144.5
ENST00000599469.5
ENST00000598354.5
ENST00000598103.5
ENST00000600340.5
ENST00000630257.2
ENST00000625258.1
LIX1L antisense RNA 1
novel protein, lncRNA-POLR3GL readthrough
chr18_-_55401751 3.63 ENST00000537856.7
transcription factor 4
chr6_-_13487593 3.04 ENST00000379287.4
ENST00000603223.1
glucose-fructose oxidoreductase domain containing 1
chr11_-_129192291 3.02 ENST00000682385.1
Rho GTPase activating protein 32
chr9_-_133149334 2.99 ENST00000393160.7
ral guanine nucleotide dissociation stimulator
chr15_-_58065734 2.93 ENST00000347587.7
aldehyde dehydrogenase 1 family member A2
chr1_+_151612001 2.89 ENST00000642376.1
ENST00000368843.8
ENST00000458013.7
sorting nexin 27
chr2_-_25252072 2.86 ENST00000683760.1
DNA methyltransferase 3 alpha
chr15_-_58065870 2.85 ENST00000537372.5
aldehyde dehydrogenase 1 family member A2
chr15_-_58065703 2.83 ENST00000249750.9
aldehyde dehydrogenase 1 family member A2
chr17_-_39401593 2.80 ENST00000394294.7
ENST00000264658.11
ENST00000583610.5
ENST00000647139.1
F-box and leucine rich repeat protein 20
chr1_+_95117324 2.71 ENST00000370203.9
ENST00000456991.5
TLC domain containing 4
chr5_-_115180037 2.70 ENST00000514154.1
ENST00000282369.7
tripartite motif containing 36
chr15_-_82806054 2.67 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
fibronectin type III and SPRY domain containing 2
chr14_+_78170336 2.65 ENST00000634499.2
ENST00000335750.7
neurexin 3
chr10_-_97771954 2.63 ENST00000266066.4
secreted frizzled related protein 5
chr14_+_78403686 2.59 ENST00000553631.1
ENST00000554719.5
neurexin 3
chr11_-_129192198 2.58 ENST00000310343.13
Rho GTPase activating protein 32
chr8_+_737595 2.57 ENST00000637795.2
DLG associated protein 2
chr11_-_33869816 2.49 ENST00000395833.7
LIM domain only 2
chr2_-_25252251 2.41 ENST00000380746.8
ENST00000402667.1
DNA methyltransferase 3 alpha
chr11_-_33892010 2.37 ENST00000257818.3
LIM domain only 2
chr8_+_102551583 2.35 ENST00000285402.4
outer dense fiber of sperm tails 1
chr9_-_72953047 2.35 ENST00000297785.8
ENST00000376939.5
aldehyde dehydrogenase 1 family member A1
chr1_-_1074303 2.30 ENST00000453464.3
ring finger protein 223
chr17_-_42181116 2.24 ENST00000264661.4
potassium voltage-gated channel subfamily H member 4
chr3_-_52409783 2.10 ENST00000470173.1
ENST00000296288.9
ENST00000460680.6
BRCA1 associated protein 1
chr17_-_42181081 2.00 ENST00000607371.5
potassium voltage-gated channel subfamily H member 4
chr3_-_66500973 1.96 ENST00000383703.3
ENST00000273261.8
leucine rich repeats and immunoglobulin like domains 1
chr13_+_114281577 1.92 ENST00000375299.8
ENST00000492270.1
ENST00000351487.5
UPF3A regulator of nonsense mediated mRNA decay
chr1_+_154405326 1.84 ENST00000368485.8
interleukin 6 receptor
chr9_+_133534697 1.83 ENST00000651351.2
ADAMTS like 2
chr5_+_55024250 1.78 ENST00000231009.3
granzyme K
chr7_-_150978284 1.78 ENST00000262186.10
potassium voltage-gated channel subfamily H member 2
chr7_+_143316105 1.76 ENST00000343257.7
ENST00000650516.1
chloride voltage-gated channel 1
chr1_-_110606009 1.66 ENST00000640774.2
ENST00000638616.2
potassium voltage-gated channel subfamily A member 2
chr11_-_114400417 1.60 ENST00000325636.8
ENST00000623205.2
chromosome 11 open reading frame 71
chr17_+_27471999 1.58 ENST00000583370.5
ENST00000509603.6
ENST00000268763.10
ENST00000398988.7
kinase suppressor of ras 1
chr1_+_154405193 1.56 ENST00000622330.4
ENST00000344086.8
interleukin 6 receptor
chr5_-_34043205 1.47 ENST00000382065.8
ENST00000231338.7
C1q and TNF related 3
chr16_+_2537997 1.47 ENST00000441549.7
ENST00000268673.11
ENST00000342085.9
ENST00000389224.7
3-phosphoinositide dependent protein kinase 1
chr2_+_60881553 1.47 ENST00000394479.4
REL proto-oncogene, NF-kB subunit
chr5_-_79514127 1.46 ENST00000334082.11
homer scaffold protein 1
chr22_-_41946729 1.46 ENST00000402420.1
centromere protein M
chr12_+_57460127 1.44 ENST00000532291.5
ENST00000543426.5
ENST00000546141.5
GLI family zinc finger 1
chr5_+_114362286 1.42 ENST00000610748.4
ENST00000264773.7
potassium calcium-activated channel subfamily N member 2
chr5_-_75511596 1.41 ENST00000643158.1
ENST00000261415.12
ENST00000646713.1
ENST00000643773.1
ENST00000645866.1
ENST00000644072.2
ENST00000643780.2
ENST00000645483.1
ENST00000642556.1
ENST00000646511.1
ceramide transporter 1
chr21_+_25734948 1.40 ENST00000400075.4
GA binding protein transcription factor subunit alpha
chr2_+_60881515 1.38 ENST00000295025.12
REL proto-oncogene, NF-kB subunit
chr11_+_6481473 1.34 ENST00000530751.1
ENST00000254616.11
translocase of inner mitochondrial membrane 10B
chr5_+_114362043 1.31 ENST00000673685.1
potassium calcium-activated channel subfamily N member 2
chr2_-_110534010 1.31 ENST00000437167.1
RANBP2 like and GRIP domain containing 6
chrX_+_70423031 1.30 ENST00000453994.6
ENST00000538649.5
ENST00000536730.5
glycerophosphodiester phosphodiesterase domain containing 2
chr16_-_67931859 1.29 ENST00000574481.6
ENST00000571044.5
ENST00000571605.1
chymotrypsin like
chr20_-_5001474 1.28 ENST00000338244.6
solute carrier family 23 member 2
chr1_-_11848345 1.26 ENST00000376476.1
natriuretic peptide A
chr17_-_27893339 1.24 ENST00000460380.6
ENST00000379102.8
ENST00000508862.5
ENST00000582441.1
LYR motif containing 9
novel protein
chr5_-_60945008 1.24 ENST00000683052.1
ENST00000675229.1
ENST00000265038.10
ENST00000676185.1
ENST00000682217.1
ENST00000439176.6
ENST00000675042.2
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
chrX_+_70423301 1.22 ENST00000374382.4
glycerophosphodiester phosphodiesterase domain containing 2
chr14_+_20999255 1.22 ENST00000554422.5
ENST00000298681.5
solute carrier family 39 member 2
chr22_-_40819324 1.17 ENST00000435456.7
ENST00000434185.1
ENST00000544408.5
solute carrier family 25 member 17
chr1_-_225889143 1.11 ENST00000272134.5
left-right determination factor 1
chr9_-_114930508 1.09 ENST00000223795.3
ENST00000618336.4
TNF superfamily member 8
chr20_+_11917859 1.06 ENST00000618296.4
ENST00000378226.7
BTB domain containing 3
chr14_+_90398159 1.05 ENST00000544280.6
calmodulin 1
chr5_+_140107777 1.04 ENST00000505703.2
ENST00000651386.1
purine rich element binding protein A
chr15_+_92393841 1.01 ENST00000268164.8
ENST00000539113.5
ENST00000555434.1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr1_+_26788166 1.00 ENST00000374145.6
ENST00000431541.6
ENST00000674273.1
phosphatidylinositol glycan anchor biosynthesis class V
chr10_+_93073873 1.00 ENST00000224356.5
cytochrome P450 family 26 subfamily A member 1
chr11_-_126062782 0.98 ENST00000531738.6
cell adhesion associated, oncogene regulated
chr1_+_172659095 0.94 ENST00000367721.3
ENST00000340030.4
Fas ligand
chr12_+_48818763 0.92 ENST00000548279.5
ENST00000547230.5
calcium voltage-gated channel auxiliary subunit beta 3
chr17_-_63911236 0.89 ENST00000438387.6
ENST00000346606.10
ENST00000309894.6
ENST00000561003.5
ENST00000450719.3
ENST00000259003.14
chorionic somatomammotropin hormone like 1
chr12_-_26125023 0.88 ENST00000242728.5
basic helix-loop-helix family member e41
chr3_-_49422429 0.88 ENST00000637682.1
ENST00000427987.6
ENST00000636199.1
ENST00000638063.1
ENST00000636865.1
ENST00000458307.6
ENST00000273588.9
ENST00000635808.1
ENST00000636522.1
ENST00000636597.1
ENST00000538581.6
ENST00000395338.7
ENST00000462048.2
aminomethyltransferase
chr5_-_75511213 0.88 ENST00000644445.1
ENST00000646302.1
ENST00000644912.1
ENST00000642809.1
ENST00000644377.1
ceramide transporter 1
chr10_-_75109085 0.86 ENST00000607131.5
dual specificity phosphatase 13
chr7_+_27242796 0.81 ENST00000496902.7
even-skipped homeobox 1
chr17_-_63918817 0.80 ENST00000458650.6
ENST00000351388.8
ENST00000342364.8
ENST00000617086.1
ENST00000323322.10
ENST00000392824.8
growth hormone 1
chorionic somatomammotropin hormone like 1
chr9_+_133534807 0.77 ENST00000393060.1
ADAMTS like 2
chr17_-_63896568 0.74 ENST00000610991.1
ENST00000316193.13
ENST00000329882.8
chorionic somatomammotropin hormone 1
chr11_-_128867364 0.73 ENST00000440599.6
ENST00000324036.7
potassium inwardly rectifying channel subfamily J member 1
chr1_+_26787926 0.72 ENST00000674202.1
ENST00000674222.1
phosphatidylinositol glycan anchor biosynthesis class V
chr3_-_187745460 0.70 ENST00000406870.7
BCL6 transcription repressor
chr13_-_102401599 0.68 ENST00000376131.8
fibroblast growth factor 14
chr11_-_128867268 0.66 ENST00000392665.6
ENST00000392666.6
potassium inwardly rectifying channel subfamily J member 1
chr6_-_31112566 0.65 ENST00000259870.4
chromosome 6 open reading frame 15
chr2_+_62705644 0.63 ENST00000427809.5
ENST00000405482.5
ENST00000431489.6
EH domain binding protein 1
chr17_-_63873676 0.58 ENST00000613718.3
ENST00000392886.7
ENST00000345366.8
ENST00000336844.9
ENST00000560142.5
chorionic somatomammotropin hormone 2
chr1_-_11847772 0.55 ENST00000376480.7
ENST00000610706.1
natriuretic peptide A
chr12_+_48818478 0.54 ENST00000547818.5
ENST00000301050.7
ENST00000547392.5
calcium voltage-gated channel auxiliary subunit beta 3
chr22_+_40045451 0.54 ENST00000402203.5
trinucleotide repeat containing adaptor 6B
chr14_+_32939243 0.53 ENST00000346562.6
ENST00000548645.5
ENST00000356141.8
ENST00000357798.9
neuronal PAS domain protein 3
chr11_-_18322122 0.48 ENST00000349215.8
ENST00000396253.7
ENST00000438420.6
HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
chr1_+_158355894 0.46 ENST00000368162.2
CD1e molecule
chr12_+_50057548 0.41 ENST00000228468.8
ENST00000447966.7
acid sensing ion channel subunit 1
chr17_-_78360066 0.40 ENST00000587578.1
ENST00000330871.3
suppressor of cytokine signaling 3
chr9_-_72365198 0.39 ENST00000376962.10
ENST00000376960.8
zinc finger AN1-type containing 5
chr3_+_134795248 0.38 ENST00000398015.8
EPH receptor B1
chr2_+_62705866 0.38 ENST00000263991.9
EH domain binding protein 1
chr1_+_26787667 0.33 ENST00000674335.1
phosphatidylinositol glycan anchor biosynthesis class V
chrX_+_71223216 0.31 ENST00000361726.7
gap junction protein beta 1
chr2_+_11556337 0.25 ENST00000234142.9
growth regulating estrogen receptor binding 1
chr11_+_18322541 0.25 ENST00000534641.5
ENST00000265963.9
ENST00000525831.5
general transcription factor IIH subunit 1
chr12_-_119803383 0.25 ENST00000392520.2
ENST00000678677.1
ENST00000679249.1
ENST00000676849.1
citron rho-interacting serine/threonine kinase
chr3_+_134795277 0.25 ENST00000647596.1
EPH receptor B1
chr17_-_41065879 0.20 ENST00000394015.3
keratin associated protein 2-4
chr1_-_145927447 0.18 ENST00000632555.1
ENST00000369307.4
ENST00000583313.7
RNA binding motif protein 8A
chr4_+_159267737 0.17 ENST00000264431.8
Rap guanine nucleotide exchange factor 2
chr10_-_101695119 0.15 ENST00000331272.9
ENST00000664783.1
F-box and WD repeat domain containing 4
chr1_+_26410809 0.15 ENST00000254231.4
ENST00000326279.11
lin-28 homolog A
chr19_+_35031263 0.11 ENST00000640135.1
ENST00000596348.2
sodium voltage-gated channel beta subunit 1
chr17_-_49677976 0.09 ENST00000665825.1
ENST00000508805.5
ENST00000515508.6
ENST00000451526.6
ENST00000507970.5
speckle type BTB/POZ protein
chr10_+_31319125 0.07 ENST00000320985.14
ENST00000560721.6
ENST00000558440.5
ENST00000424869.6
ENST00000542815.7
zinc finger E-box binding homeobox 1
chr5_+_150661243 0.07 ENST00000517768.6
myozenin 3
chrX_+_124346544 0.06 ENST00000371139.9
SH2 domain containing 1A

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.6 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
3.3 19.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
1.7 5.2 GO:0046878 positive regulation of saliva secretion(GO:0046878)
1.5 4.4 GO:0060005 vestibular reflex(GO:0060005)
1.5 5.8 GO:1990834 response to odorant(GO:1990834)
1.4 4.2 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
1.4 12.3 GO:0001661 conditioned taste aversion(GO:0001661)
1.1 11.1 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
1.0 8.6 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.9 5.3 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.8 3.4 GO:0002384 hepatic immune response(GO:0002384)
0.8 6.0 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.7 4.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.7 2.6 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.5 1.4 GO:0060032 notochord regression(GO:0060032)
0.5 6.4 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4 2.1 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.4 2.3 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.4 1.2 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.4 2.6 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.4 1.5 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.3 0.7 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.3 11.8 GO:0048665 neuron fate specification(GO:0048665)
0.3 1.0 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.3 12.9 GO:0008045 motor neuron axon guidance(GO:0008045)
0.3 2.0 GO:0048840 otolith development(GO:0048840)
0.3 14.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 1.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 6.9 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 15.9 GO:0007602 phototransduction(GO:0007602)
0.2 4.9 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 1.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 2.7 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.2 0.9 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.2 0.7 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 1.7 GO:0021631 optic nerve morphogenesis(GO:0021631) optic nerve structural organization(GO:0021633)
0.2 1.5 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.2 5.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 2.9 GO:0001767 establishment of lymphocyte polarity(GO:0001767)
0.2 1.8 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 2.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 2.5 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.3 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 1.5 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.8 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.1 12.8 GO:0007422 peripheral nervous system development(GO:0007422)
0.1 2.1 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.4 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 1.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 1.5 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577)
0.1 1.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 8.0 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 0.2 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 5.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 1.2 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.9 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.5 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 1.5 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.5 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 1.1 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.7 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.3 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 1.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 1.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 3.6 GO:0065004 protein-DNA complex assembly(GO:0065004)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 12.3 GO:0035976 AP1 complex(GO:0035976)
1.5 4.4 GO:0032426 stereocilium tip(GO:0032426)
1.3 14.6 GO:0005955 calcineurin complex(GO:0005955)
0.7 2.1 GO:0035517 PR-DUB complex(GO:0035517)
0.7 3.4 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.4 11.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.4 1.8 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.3 2.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.3 5.3 GO:0001741 XY body(GO:0001741)
0.3 18.7 GO:0043198 dendritic shaft(GO:0043198)
0.3 0.8 GO:0070195 growth hormone receptor complex(GO:0070195)
0.3 2.4 GO:0001520 outer dense fiber(GO:0001520)
0.3 4.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 2.9 GO:0071203 WASH complex(GO:0071203)
0.2 2.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 2.6 GO:0005883 neurofilament(GO:0005883)
0.1 1.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 21.8 GO:0043204 perikaryon(GO:0043204)
0.1 1.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 24.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 5.9 GO:0014704 intercalated disc(GO:0014704)
0.1 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 5.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.8 GO:0042629 mast cell granule(GO:0042629)
0.0 1.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.4 GO:0097546 ciliary base(GO:0097546)
0.0 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0031082 BLOC complex(GO:0031082)
0.0 6.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0005901 caveola(GO:0005901)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.7 GO:0005657 replication fork(GO:0005657)
0.0 1.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.3 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
1.3 18.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.1 3.4 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.9 11.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.9 5.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.9 6.0 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.7 4.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.7 2.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.6 6.4 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.6 11.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.5 2.6 GO:0050436 microfibril binding(GO:0050436)
0.5 2.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4 1.3 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.3 14.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 0.9 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.3 18.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 2.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.3 1.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 6.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.6 GO:0070052 collagen V binding(GO:0070052)
0.2 4.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 0.8 GO:0005148 prolactin receptor binding(GO:0005148)
0.2 5.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 3.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.2 GO:0015216 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.2 17.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 4.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 7.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 2.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 5.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.5 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 2.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 11.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 2.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 5.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 9.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 1.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.0 GO:0001972 retinoic acid binding(GO:0001972)
0.0 8.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.2 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 5.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0001784 phosphotyrosine binding(GO:0001784)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 15.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 11.1 PID AURORA A PATHWAY Aurora A signaling
0.2 14.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 3.4 ST STAT3 PATHWAY STAT3 Pathway
0.1 17.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.8 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 1.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 4.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 4.6 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 3.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.4 PID EPO PATHWAY EPO signaling pathway
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 15.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 2.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 3.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 24.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.0 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.1 3.0 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 7.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 14.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 1.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 4.1 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 1.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 1.0 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 3.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.8 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.2 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 5.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation