ISMARA results: TCF7L1

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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF7L1

Z-value: 1.14

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Transcription factors associated with TCF7L1

Gene Symbol	Gene ID	Gene Info
TCF7L1 Ensembl NCBI GeneCards UniProt	ENSG00000152284.5	TCF7L1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF7L1	hg38_v1_chr2_+_85133376_85133474	0.02	7.5e-01	Click!

Activity profile of TCF7L1 motif

Sorted Z-values of TCF7L1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L1

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View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr6_-_106975452 Show fit	14.70	ENST00000619869.1 ENST00000619133.4	CD24 Ensembl NCBI GeneCards UniProt Show fit	CD24 molecule
chr6_-_106975309 Show fit	14.70	ENST00000615659.1	CD24 Ensembl NCBI GeneCards UniProt Show fit	CD24 molecule
chr1_-_153550083 Show fit	12.28	ENST00000368714.1	S100A4 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A4
chr14_+_75280078 Show fit	11.07	ENST00000555347.1	FOS Ensembl NCBI GeneCards UniProt Show fit	Fos proto-oncogene, AP-1 transcription factor subunit
chr6_-_106974721 Show fit	10.86	ENST00000606017.2 ENST00000620405.1	CD24 Ensembl NCBI GeneCards UniProt Show fit	CD24 molecule
chr18_+_3450036 Show fit	10.66	ENST00000546979.5 ENST00000343820.10 ENST00000551402.1 ENST00000577543.5	TGIF1 Ensembl NCBI GeneCards UniProt Show fit	TGFB induced factor homeobox 1
chr18_+_3449817 Show fit	10.56	ENST00000407501.6	TGIF1 Ensembl NCBI GeneCards UniProt Show fit	TGFB induced factor homeobox 1
chr14_-_22982258 Show fit	9.57	ENST00000555074.1 ENST00000361265.8	ENSG00000259132.1 Ensembl NCBI GeneCards UniProt Show fit AJUBA Ensembl NCBI GeneCards UniProt Show fit	novel protein ajuba LIM protein
chr21_-_44910630 Show fit	9.32	ENST00000320216.10 ENST00000397852.5	ITGB2 Ensembl NCBI GeneCards UniProt Show fit	integrin subunit beta 2
chr7_+_80602150 Show fit	8.77	ENST00000309881.11	CD36 Ensembl NCBI GeneCards UniProt Show fit	CD36 molecule
chr7_-_149028452 Show fit	8.72	ENST00000413966.1 ENST00000652332.1	PDIA4 Ensembl NCBI GeneCards UniProt Show fit	protein disulfide isomerase family A member 4
chr7_+_80602200 Show fit	8.65	ENST00000534394.5	CD36 Ensembl NCBI GeneCards UniProt Show fit	CD36 molecule
chr14_-_64942783 Show fit	8.45	ENST00000612794.1	GPX2 Ensembl NCBI GeneCards UniProt Show fit	glutathione peroxidase 2
chr7_-_149028651 Show fit	8.37	ENST00000286091.9	PDIA4 Ensembl NCBI GeneCards UniProt Show fit	protein disulfide isomerase family A member 4
chr7_+_116210501 Show fit	7.62	ENST00000455989.1 ENST00000358204.9	TES Ensembl NCBI GeneCards UniProt Show fit	testin LIM domain protein
chr5_-_176537361 Show fit	7.62	ENST00000274811.9	RNF44 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 44
chr17_-_7394240 Show fit	7.34	ENST00000576362.5 ENST00000571078.5	PLSCR3 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 3
chr14_-_34875348 Show fit	7.22	ENST00000360310.6	BAZ1A Ensembl NCBI GeneCards UniProt Show fit	bromodomain adjacent to zinc finger domain 1A
chr17_-_7394514 Show fit	7.19	ENST00000571802.1 ENST00000619711.5 ENST00000576201.5 ENST00000573213.1 ENST00000324822.15	PLSCR3 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 3
chr7_-_140176970 Show fit	7.15	ENST00000397560.7	KDM7A Ensembl NCBI GeneCards UniProt Show fit	lysine demethylase 7A
chr14_-_34874887 Show fit	6.79	ENST00000382422.6	BAZ1A Ensembl NCBI GeneCards UniProt Show fit	bromodomain adjacent to zinc finger domain 1A
chr17_-_7394800 Show fit	6.63	ENST00000574401.5	PLSCR3 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 3
chrX_-_136880715 Show fit	6.42	ENST00000431446.7 ENST00000320676.11 ENST00000562646.5	RBMX Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein X-linked
chr6_-_169724467 Show fit	6.35	ENST00000339209.9	PHF10 Ensembl NCBI GeneCards UniProt Show fit	PHD finger protein 10
chr7_-_27180230 Show fit	6.31	ENST00000396344.4	HOXA10 Ensembl NCBI GeneCards UniProt Show fit	homeobox A10
chr7_+_80646305 Show fit	6.06	ENST00000426978.5 ENST00000432207.5	CD36 Ensembl NCBI GeneCards UniProt Show fit	CD36 molecule
chr20_+_57391388 Show fit	5.94	ENST00000356208.10 ENST00000440234.6	RBM38 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 38
chr12_+_103965863 Show fit	5.94	ENST00000392872.8 ENST00000537100.5	TDG Ensembl NCBI GeneCards UniProt Show fit	thymine DNA glycosylase
chr7_+_80646436 Show fit	5.82	ENST00000419819.2	CD36 Ensembl NCBI GeneCards UniProt Show fit	CD36 molecule
chrX_+_101390824 Show fit	5.40	ENST00000427805.6 ENST00000614077.4	RPL36A Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L36a
chr21_+_29299368 Show fit	5.21	ENST00000399921.5	BACH1 Ensembl NCBI GeneCards UniProt Show fit	BTB domain and CNC homolog 1
chr1_+_182839338 Show fit	5.18	ENST00000367549.4	DHX9 Ensembl NCBI GeneCards UniProt Show fit	DExH-box helicase 9
chr12_+_103965835 Show fit	5.06	ENST00000266775.13 ENST00000544861.5	TDG Ensembl NCBI GeneCards UniProt Show fit	thymine DNA glycosylase
chr11_+_69641146 Show fit	4.96	ENST00000227507.3 ENST00000536559.1	CCND1 Ensembl NCBI GeneCards UniProt Show fit	cyclin D1
chr12_+_103965798 Show fit	4.94	ENST00000436021.6	TDG Ensembl NCBI GeneCards UniProt Show fit	thymine DNA glycosylase
chr6_-_106975616 Show fit	4.86	ENST00000610952.1	CD24 Ensembl NCBI GeneCards UniProt Show fit	CD24 molecule
chr1_+_109548567 Show fit	4.74	ENST00000369851.7	GNAI3 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha i3
chr6_+_143608170 Show fit	4.72	ENST00000427704.6 ENST00000305766.10	PHACTR2 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 2
chr8_-_101206064 Show fit	4.66	ENST00000518336.5 ENST00000520454.1	ZNF706 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 706
chr7_-_25228485 Show fit	4.62	ENST00000222674.2	NPVF Ensembl NCBI GeneCards UniProt Show fit	neuropeptide VF precursor
chr8_-_17246846 Show fit	4.53	ENST00000628418.1 ENST00000361272.9 ENST00000523917.5	CNOT7 Ensembl NCBI GeneCards UniProt Show fit	CCR4-NOT transcription complex subunit 7
chrX_-_154371210 Show fit	4.43	ENST00000369856.8 ENST00000422373.6 ENST00000360319.9	FLNA Ensembl NCBI GeneCards UniProt Show fit	filamin A
chrX_+_101391202 Show fit	4.42	ENST00000471855.1	RPL36A Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L36a
chr11_+_65572349 Show fit	4.34	ENST00000316409.2 ENST00000449319.2 ENST00000530349.2	FAM89B Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 89 member B
chr9_-_72364504 Show fit	4.31	ENST00000237937.7 ENST00000343431.6 ENST00000376956.3	ZFAND5 Ensembl NCBI GeneCards UniProt Show fit	zinc finger AN1-type containing 5
chr13_+_29428709 Show fit	4.28	ENST00000542829.1	MTUS2 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated scaffold protein 2
chrX_+_101390976 Show fit	4.27	ENST00000392994.7	RPL36A Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L36a
chr17_-_10518536 Show fit	4.22	ENST00000226207.6	MYH1 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 1
chr12_+_53097656 Show fit	4.21	ENST00000301464.4	IGFBP6 Ensembl NCBI GeneCards UniProt Show fit	insulin like growth factor binding protein 6
chr15_+_40844018 Show fit	4.19	ENST00000344051.8 ENST00000562057.6	SPINT1 Ensembl NCBI GeneCards UniProt Show fit	serine peptidase inhibitor, Kunitz type 1
chr8_+_30095649 Show fit	4.13	ENST00000518192.5	LEPROTL1 Ensembl NCBI GeneCards UniProt Show fit	leptin receptor overlapping transcript like 1
chr6_+_63571702 Show fit	4.06	ENST00000672924.1	PTP4A1 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase 4A1
chr19_+_40751179 Show fit	4.02	ENST00000243563.8 ENST00000601393.1	SNRPA Ensembl NCBI GeneCards UniProt Show fit	small nuclear ribonucleoprotein polypeptide A
chr2_+_10043524 Show fit	4.00	ENST00000305883.6	KLF11 Ensembl NCBI GeneCards UniProt Show fit	Kruppel like factor 11
chr3_+_179562886 Show fit	3.98	ENST00000450518.6 ENST00000392662.5 ENST00000429709.7 ENST00000490364.1	ACTL6A Ensembl NCBI GeneCards UniProt Show fit	actin like 6A
chrX_+_101391000 Show fit	3.96	ENST00000553110.8 ENST00000409338.5 ENST00000409170.3	RPL36A Ensembl NCBI GeneCards UniProt Show fit RPL36A-HNRNPH2 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L36a RPL36A-HNRNPH2 readthrough
chr7_-_148884266 Show fit	3.91	ENST00000483967.5 ENST00000320356.7	EZH2 Ensembl NCBI GeneCards UniProt Show fit	enhancer of zeste 2 polycomb repressive complex 2 subunit
chr17_-_10469558 Show fit	3.90	ENST00000255381.2	MYH4 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 4
chr15_-_101252040 Show fit	3.82	ENST00000254190.4	CHSY1 Ensembl NCBI GeneCards UniProt Show fit	chondroitin sulfate synthase 1
chr5_+_134114673 Show fit	3.79	ENST00000342854.10 ENST00000395029.5	TCF7 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 7
chr4_-_121072519 Show fit	3.68	ENST00000379692.9	NDNF Ensembl NCBI GeneCards UniProt Show fit	neuron derived neurotrophic factor
chr10_+_22316375 Show fit	3.64	ENST00000376836.8 ENST00000456711.5 ENST00000444869.5 ENST00000475460.6 ENST00000602390.5 ENST00000489125.2	COMMD3 Ensembl NCBI GeneCards UniProt Show fit COMMD3-BMI1 Ensembl NCBI GeneCards UniProt Show fit	COMM domain containing 3 COMMD3-BMI1 readthrough
chr1_+_32013848 Show fit	3.63	ENST00000327300.12 ENST00000492989.1	KHDRBS1 Ensembl NCBI GeneCards UniProt Show fit	KH RNA binding domain containing, signal transduction associated 1
chr7_+_73830988 Show fit	3.60	ENST00000340958.4	CLDN4 Ensembl NCBI GeneCards UniProt Show fit	claudin 4
chr3_-_47781837 Show fit	3.59	ENST00000254480.10	SMARCC1 Ensembl NCBI GeneCards UniProt Show fit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
chr10_+_21524627 Show fit	3.53	ENST00000651097.1	MLLT10 Ensembl NCBI GeneCards UniProt Show fit	MLLT10 histone lysine methyltransferase DOT1L cofactor
chrX_+_153494970 Show fit	3.48	ENST00000331595.9 ENST00000431891.1	BGN Ensembl NCBI GeneCards UniProt Show fit	biglycan
chr7_-_148884159 Show fit	3.47	ENST00000478654.5 ENST00000460911.5 ENST00000350995.6	EZH2 Ensembl NCBI GeneCards UniProt Show fit	enhancer of zeste 2 polycomb repressive complex 2 subunit
chr11_-_5234475 Show fit	3.46	ENST00000292901.7 ENST00000650601.1 ENST00000417377.1	HBD Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit delta
chr1_-_65067707 Show fit	3.46	ENST00000672099.1 ENST00000671954.1 ENST00000672434.1 ENST00000673502.1 ENST00000672751.1	JAK1 Ensembl NCBI GeneCards UniProt Show fit	Janus kinase 1
chr10_+_22316445 Show fit	3.42	ENST00000448361.5	COMMD3 Ensembl NCBI GeneCards UniProt Show fit	COMM domain containing 3
chr7_-_27174274 Show fit	3.40	ENST00000283921.5	HOXA10 Ensembl NCBI GeneCards UniProt Show fit	homeobox A10
chr7_-_106285898 Show fit	3.32	ENST00000424768.2 ENST00000681255.1	NAMPT Ensembl NCBI GeneCards UniProt Show fit	nicotinamide phosphoribosyltransferase
chr6_+_118894144 Show fit	3.31	ENST00000229595.6	ASF1A Ensembl NCBI GeneCards UniProt Show fit	anti-silencing function 1A histone chaperone
chr7_+_116672187 Show fit	3.30	ENST00000318493.11 ENST00000397752.8	MET Ensembl NCBI GeneCards UniProt Show fit	MET proto-oncogene, receptor tyrosine kinase
chr18_+_70288991 Show fit	3.27	ENST00000397942.4	SOCS6 Ensembl NCBI GeneCards UniProt Show fit	suppressor of cytokine signaling 6
chr11_+_36296281 Show fit	3.27	ENST00000530639.6	PRR5L Ensembl NCBI GeneCards UniProt Show fit	proline rich 5 like
chr17_-_40937445 Show fit	3.26	ENST00000436344.7 ENST00000485751.1	KRT23 Ensembl NCBI GeneCards UniProt Show fit	keratin 23
chr15_+_74782069 Show fit	3.26	ENST00000220003.14 ENST00000439220.6	CSK Ensembl NCBI GeneCards UniProt Show fit	C-terminal Src kinase
chr3_+_137764296 Show fit	3.20	ENST00000306087.3	SOX14 Ensembl NCBI GeneCards UniProt Show fit	SRY-box transcription factor 14
chr3_-_160565560 Show fit	3.20	ENST00000334256.9 ENST00000676866.1 ENST00000469804.1	KPNA4 Ensembl NCBI GeneCards UniProt Show fit	karyopherin subunit alpha 4
chr14_+_20455185 Show fit	3.20	ENST00000555414.5 ENST00000553681.5	APEX1 Ensembl NCBI GeneCards UniProt Show fit	apurinic/apyrimidinic endodeoxyribonuclease 1
chr8_-_42377227 Show fit	3.18	ENST00000220812.3	DKK4 Ensembl NCBI GeneCards UniProt Show fit	dickkopf WNT signaling pathway inhibitor 4
chr1_+_93448155 Show fit	3.15	ENST00000370253.6	FNBP1L Ensembl NCBI GeneCards UniProt Show fit	formin binding protein 1 like
chr4_+_2818155 Show fit	3.13	ENST00000511747.6	SH3BP2 Ensembl NCBI GeneCards UniProt Show fit	SH3 domain binding protein 2
chr12_+_54033026 Show fit	3.06	ENST00000312492.3	HOXC5 Ensembl NCBI GeneCards UniProt Show fit	homeobox C5
chr17_-_40937641 Show fit	2.97	ENST00000209718.8	KRT23 Ensembl NCBI GeneCards UniProt Show fit	keratin 23
chr7_-_27174253 Show fit	2.93	ENST00000613671.1	HOXA10 Ensembl NCBI GeneCards UniProt Show fit	homeobox A10
chr16_-_46831134 Show fit	2.91	ENST00000394806.6 ENST00000285697.9	C16orf87 Ensembl NCBI GeneCards UniProt Show fit	chromosome 16 open reading frame 87
chr5_+_72816643 Show fit	2.90	ENST00000337273.10 ENST00000523768.5	TNPO1 Ensembl NCBI GeneCards UniProt Show fit	transportin 1
chr8_-_143973520 Show fit	2.89	ENST00000356346.7	PLEC Ensembl NCBI GeneCards UniProt Show fit	plectin
chr6_-_27473058 Show fit	2.87	ENST00000683788.1 ENST00000211936.10	ZNF184 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 184
chr17_+_9162935 Show fit	2.83	ENST00000436734.1	NTN1 Ensembl NCBI GeneCards UniProt Show fit	netrin 1
chr10_+_69802424 Show fit	2.82	ENST00000673802.2 ENST00000517713.5 ENST00000520133.5 ENST00000522165.5 ENST00000673641.2 ENST00000673628.2	COL13A1 Ensembl NCBI GeneCards UniProt Show fit	collagen type XIII alpha 1 chain
chr14_+_57390544 Show fit	2.81	ENST00000555166.5 ENST00000556492.6 ENST00000554703.1	NAA30 Ensembl NCBI GeneCards UniProt Show fit	N-alpha-acetyltransferase 30, NatC catalytic subunit
chr10_+_21524670 Show fit	2.78	ENST00000631589.1	MLLT10 Ensembl NCBI GeneCards UniProt Show fit	MLLT10 histone lysine methyltransferase DOT1L cofactor
chr2_+_69013379 Show fit	2.70	ENST00000409349.7	ANTXR1 Ensembl NCBI GeneCards UniProt Show fit	ANTXR cell adhesion molecule 1
chr6_-_27472681 Show fit	2.67	ENST00000377419.1	ZNF184 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 184
chr14_-_50561119 Show fit	2.66	ENST00000555216.5	MAP4K5 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 5
chr10_+_69801892 Show fit	2.59	ENST00000398978.8 ENST00000645393.2 ENST00000354547.7 ENST00000674121.1 ENST00000673842.1 ENST00000520267.5	COL13A1 Ensembl NCBI GeneCards UniProt Show fit	collagen type XIII alpha 1 chain
chr9_+_125748175 Show fit	2.48	ENST00000491787.7 ENST00000447726.6	PBX3 Ensembl NCBI GeneCards UniProt Show fit	PBX homeobox 3
chr6_+_133953210 Show fit	2.44	ENST00000367869.1 ENST00000237264.9 ENST00000674115.1	TBPL1 Ensembl NCBI GeneCards UniProt Show fit ENSG00000288529.1 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein like 1 novel protein
chr6_+_108559742 Show fit	2.44	ENST00000343882.10	FOXO3 Ensembl NCBI GeneCards UniProt Show fit	forkhead box O3
chrX_+_70268305 Show fit	2.44	ENST00000374495.7	ARR3 Ensembl NCBI GeneCards UniProt Show fit	arrestin 3
chr2_+_227813834 Show fit	2.39	ENST00000358813.5 ENST00000409189.7	CCL20 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 20
chr17_+_77451244 Show fit	2.38	ENST00000591088.5	SEPTIN9 Ensembl NCBI GeneCards UniProt Show fit	septin 9
chr20_-_63956382 Show fit	2.35	ENST00000358711.7 ENST00000354216.11	UCKL1 Ensembl NCBI GeneCards UniProt Show fit	uridine-cytidine kinase 1 like 1
chr1_+_35883189 Show fit	2.35	ENST00000674304.1 ENST00000373204.6 ENST00000674426.1	AGO1 Ensembl NCBI GeneCards UniProt Show fit	argonaute RISC component 1
chr10_-_97185758 Show fit	2.35	ENST00000371070.8	SLIT1 Ensembl NCBI GeneCards UniProt Show fit	slit guidance ligand 1
chr1_+_81800368 Show fit	2.34	ENST00000674489.1 ENST00000674442.1 ENST00000674419.1 ENST00000674407.1 ENST00000674168.1 ENST00000674307.1 ENST00000674209.1 ENST00000370715.5 ENST00000370713.5 ENST00000319517.10 ENST00000627151.2 ENST00000370717.6	ADGRL2 Ensembl NCBI GeneCards UniProt Show fit	adhesion G protein-coupled receptor L2
chr4_-_102345196 Show fit	2.32	ENST00000683412.1 ENST00000682227.1	SLC39A8 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 39 member 8
chr17_+_81712236 Show fit	2.31	ENST00000545862.5 ENST00000350690.10 ENST00000331531.9	SLC25A10 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 25 member 10
chr2_-_169362527 Show fit	2.29	ENST00000649046.1 ENST00000443831.1	LRP2 Ensembl NCBI GeneCards UniProt Show fit	LDL receptor related protein 2
chr6_-_89217339 Show fit	2.22	ENST00000454853.7	GABRR1 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type A receptor subunit rho1
chr12_-_107761113 Show fit	2.19	ENST00000228437.10	PRDM4 Ensembl NCBI GeneCards UniProt Show fit	PR/SET domain 4
chr5_-_157575767 Show fit	2.18	ENST00000257527.9	ADAM19 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase domain 19
chr9_-_72365198 Show fit	2.15	ENST00000376962.10 ENST00000376960.8	ZFAND5 Ensembl NCBI GeneCards UniProt Show fit	zinc finger AN1-type containing 5
chr17_+_59565598 Show fit	2.12	ENST00000251241.9 ENST00000425628.7 ENST00000584385.5 ENST00000580030.1	DHX40 Ensembl NCBI GeneCards UniProt Show fit	DEAH-box helicase 40
chr3_-_197298092 Show fit	2.11	ENST00000392382.6	DLG1 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 1
chr15_-_78811415 Show fit	2.09	ENST00000388820.5	ADAMTS7 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase with thrombospondin type 1 motif 7
chr13_-_39038039 Show fit	2.08	ENST00000625998.2 ENST00000352251.8	PROSER1 Ensembl NCBI GeneCards UniProt Show fit	proline and serine rich 1
chr2_+_69013414 Show fit	2.06	ENST00000681816.1 ENST00000482235.2	ANTXR1 Ensembl NCBI GeneCards UniProt Show fit	ANTXR cell adhesion molecule 1
chr12_+_55931148 Show fit	2.05	ENST00000549629.5 ENST00000555218.5 ENST00000331886.10	DGKA Ensembl NCBI GeneCards UniProt Show fit	diacylglycerol kinase alpha
chr1_-_37595927 Show fit	1.98	ENST00000373062.8	GNL2 Ensembl NCBI GeneCards UniProt Show fit	G protein nucleolar 2
chr2_-_17800195 Show fit	1.98	ENST00000402989.5 ENST00000428868.1	SMC6 Ensembl NCBI GeneCards UniProt Show fit	structural maintenance of chromosomes 6
chr19_-_40285395 Show fit	1.97	ENST00000424901.5 ENST00000578123.5	AKT2 Ensembl NCBI GeneCards UniProt Show fit	AKT serine/threonine kinase 2
chr1_+_99646025 Show fit	1.97	ENST00000263174.9 ENST00000605497.5 ENST00000615664.1	PALMD Ensembl NCBI GeneCards UniProt Show fit	palmdelphin
chr6_-_33580229 Show fit	1.95	ENST00000374467.4 ENST00000442998.6 ENST00000360661.9	BAK1 Ensembl NCBI GeneCards UniProt Show fit	BCL2 antagonist/killer 1
chr14_-_23155302 Show fit	1.93	ENST00000529705.6	SLC7A8 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 7 member 8
chr8_+_30095400 Show fit	1.93	ENST00000321250.13 ENST00000518001.1 ENST00000520682.5 ENST00000442880.6 ENST00000523116.5	LEPROTL1 Ensembl NCBI GeneCards UniProt Show fit	leptin receptor overlapping transcript like 1
chr13_+_75760659 Show fit	1.91	ENST00000526202.5 ENST00000465261.6	LMO7 Ensembl NCBI GeneCards UniProt Show fit	LIM domain 7
chr7_-_151814668 Show fit	1.88	ENST00000651764.1	PRKAG2 Ensembl NCBI GeneCards UniProt Show fit	protein kinase AMP-activated non-catalytic subunit gamma 2
chr6_+_95577465 Show fit	1.88	ENST00000369293.6 ENST00000683151.1 ENST00000358812.9	MANEA Ensembl NCBI GeneCards UniProt Show fit	mannosidase endo-alpha
chr2_+_69013170 Show fit	1.87	ENST00000303714.9	ANTXR1 Ensembl NCBI GeneCards UniProt Show fit	ANTXR cell adhesion molecule 1
chr2_-_37324826 Show fit	1.87	ENST00000234179.8	PRKD3 Ensembl NCBI GeneCards UniProt Show fit	protein kinase D3
chr9_+_113463697 Show fit	1.86	ENST00000317613.10	RGS3 Ensembl NCBI GeneCards UniProt Show fit	regulator of G protein signaling 3
chr1_-_6419903 Show fit	1.84	ENST00000377836.8 ENST00000487437.5 ENST00000489730.1 ENST00000377834.8	HES2 Ensembl NCBI GeneCards UniProt Show fit	hes family bHLH transcription factor 2
chr5_+_132257670 Show fit	1.84	ENST00000253754.8 ENST00000379018.7	PDLIM4 Ensembl NCBI GeneCards UniProt Show fit	PDZ and LIM domain 4
chr6_+_20403679 Show fit	1.84	ENST00000535432.2	E2F3 Ensembl NCBI GeneCards UniProt Show fit	E2F transcription factor 3
chr14_+_39175221 Show fit	1.83	ENST00000556530.1 ENST00000216832.9	PNN Ensembl NCBI GeneCards UniProt Show fit	pinin, desmosome associated protein
chr2_+_69013282 Show fit	1.80	ENST00000409829.7	ANTXR1 Ensembl NCBI GeneCards UniProt Show fit	ANTXR cell adhesion molecule 1
chr17_-_41350824 Show fit	1.79	ENST00000007735.4	KRT33A Ensembl NCBI GeneCards UniProt Show fit	keratin 33A
chr19_-_11339573 Show fit	1.79	ENST00000222120.8	RAB3D Ensembl NCBI GeneCards UniProt Show fit	RAB3D, member RAS oncogene family
chr3_-_168095344 Show fit	1.78	ENST00000309027.4	GOLIM4 Ensembl NCBI GeneCards UniProt Show fit	golgi integral membrane protein 4
chr2_+_233712905 Show fit	1.77	ENST00000373414.4	UGT1A5 Ensembl NCBI GeneCards UniProt Show fit	UDP glucuronosyltransferase family 1 member A5
chr13_+_75760431 Show fit	1.77	ENST00000321797.12	LMO7 Ensembl NCBI GeneCards UniProt Show fit	LIM domain 7
chr7_-_151814636 Show fit	1.75	ENST00000652047.1 ENST00000650858.1	PRKAG2 Ensembl NCBI GeneCards UniProt Show fit	protein kinase AMP-activated non-catalytic subunit gamma 2
chr8_-_69833338 Show fit	1.72	ENST00000524945.5	SLCO5A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier organic anion transporter family member 5A1
chr15_+_78438199 Show fit	1.72	ENST00000258886.13	IREB2 Ensembl NCBI GeneCards UniProt Show fit	iron responsive element binding protein 2
chr18_+_6729698 Show fit	1.72	ENST00000383472.9	ARHGAP28 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 28
chr1_-_93614091 Show fit	1.69	ENST00000370247.7	BCAR3 Ensembl NCBI GeneCards UniProt Show fit	BCAR3 adaptor protein, NSP family member
chr1_-_53838276 Show fit	1.69	ENST00000371429.4	NDC1 Ensembl NCBI GeneCards UniProt Show fit	NDC1 transmembrane nucleoporin
chr13_-_71867192 Show fit	1.69	ENST00000611519.4 ENST00000620444.4 ENST00000613252.5	DACH1 Ensembl NCBI GeneCards UniProt Show fit	dachshund family transcription factor 1
chr11_-_10808304 Show fit	1.66	ENST00000532082.6	EIF4G2 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 4 gamma 2
chr2_+_190408324 Show fit	1.62	ENST00000417958.5 ENST00000432036.5 ENST00000392328.6	MFSD6 Ensembl NCBI GeneCards UniProt Show fit	major facilitator superfamily domain containing 6
chrX_+_70268324 Show fit	1.56	ENST00000307959.9 ENST00000620997.4 ENST00000480877.6	ARR3 Ensembl NCBI GeneCards UniProt Show fit	arrestin 3
chr11_-_65614195 Show fit	1.54	ENST00000309100.8 ENST00000529839.1 ENST00000526293.1	MAP3K11 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase 11
chr2_-_39121000 Show fit	1.51	ENST00000402219.8	SOS1 Ensembl NCBI GeneCards UniProt Show fit	SOS Ras/Rac guanine nucleotide exchange factor 1
chr17_-_39864126 Show fit	1.50	ENST00000351680.7 ENST00000346243.7 ENST00000350532.7 ENST00000467757.5 ENST00000439016.2	IKZF3 Ensembl NCBI GeneCards UniProt Show fit	IKAROS family zinc finger 3
chr4_+_77157189 Show fit	1.47	ENST00000316355.10 ENST00000502280.5	CCNG2 Ensembl NCBI GeneCards UniProt Show fit	cyclin G2
chr15_+_50182188 Show fit	1.45	ENST00000267842.10	SLC27A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 27 member 2
chr5_-_157575741 Show fit	1.45	ENST00000517905.1	ADAM19 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase domain 19
chrX_-_40097403 Show fit	1.42	ENST00000397354.7	BCOR Ensembl NCBI GeneCards UniProt Show fit	BCL6 corepressor
chr4_+_112231748 Show fit	1.41	ENST00000274000.10 ENST00000309703.10	AP1AR Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 1 associated regulatory protein
chr10_+_52314272 Show fit	1.40	ENST00000373970.4	DKK1 Ensembl NCBI GeneCards UniProt Show fit	dickkopf WNT signaling pathway inhibitor 1
chr5_+_43603163 Show fit	1.38	ENST00000660752.1 ENST00000654405.1 ENST00000344920.9 ENST00000657172.1 ENST00000512996.6 ENST00000671668.1	NNT Ensembl NCBI GeneCards UniProt Show fit	nicotinamide nucleotide transhydrogenase
chr2_+_169066994 Show fit	1.33	ENST00000357546.6 ENST00000432060.6	DHRS9 Ensembl NCBI GeneCards UniProt Show fit	dehydrogenase/reductase 9
chr2_-_240896144 Show fit	1.33	ENST00000388934.5	MAB21L4 Ensembl NCBI GeneCards UniProt Show fit	mab-21 like 4
chr10_+_69801874 Show fit	1.33	ENST00000357811.8	COL13A1 Ensembl NCBI GeneCards UniProt Show fit	collagen type XIII alpha 1 chain
chr11_-_119729158 Show fit	1.32	ENST00000264025.8	NECTIN1 Ensembl NCBI GeneCards UniProt Show fit	nectin cell adhesion molecule 1
chr8_+_22161655 Show fit	1.30	ENST00000318561.7	SFTPC Ensembl NCBI GeneCards UniProt Show fit	surfactant protein C
chr17_-_39864140 Show fit	1.29	ENST00000623724.3 ENST00000439167.6 ENST00000377945.7 ENST00000394189.6 ENST00000377944.7 ENST00000377958.6 ENST00000535189.5 ENST00000377952.6	IKZF3 Ensembl NCBI GeneCards UniProt Show fit	IKAROS family zinc finger 3
chr17_-_41369807 Show fit	1.28	ENST00000251646.8	KRT33B Ensembl NCBI GeneCards UniProt Show fit	keratin 33B
chr9_-_35650902 Show fit	1.27	ENST00000259608.8 ENST00000618781.1	SIT1 Ensembl NCBI GeneCards UniProt Show fit	signaling threshold regulating transmembrane adaptor 1
chr17_+_74432079 Show fit	1.27	ENST00000392627.7 ENST00000392628.7 ENST00000582473.2	GPRC5C Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor class C group 5 member C
chr14_+_74763308 Show fit	1.23	ENST00000325680.12 ENST00000552421.5	YLPM1 Ensembl NCBI GeneCards UniProt Show fit	YLP motif containing 1
chr4_-_122621011 Show fit	1.23	ENST00000611104.2 ENST00000648588.1	IL21 Ensembl NCBI GeneCards UniProt Show fit	interleukin 21
chr22_-_38084093 Show fit	1.21	ENST00000681075.1	SLC16A8 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 16 member 8
chr12_+_54008961 Show fit	1.21	ENST00000040584.6	HOXC8 Ensembl NCBI GeneCards UniProt Show fit	homeobox C8
chr7_+_120988683 Show fit	1.21	ENST00000340646.9 ENST00000310396.10	CPED1 Ensembl NCBI GeneCards UniProt Show fit	cadherin like and PC-esterase domain containing 1
chr2_+_69013337 Show fit	1.18	ENST00000463335.2	ANTXR1 Ensembl NCBI GeneCards UniProt Show fit	ANTXR cell adhesion molecule 1
chr8_-_42501224 Show fit	1.17	ENST00000520262.6 ENST00000517366.1	SLC20A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 20 member 2
chr19_-_40285277 Show fit	1.14	ENST00000579047.5 ENST00000392038.7	AKT2 Ensembl NCBI GeneCards UniProt Show fit	AKT serine/threonine kinase 2
chr3_-_197298000 Show fit	1.12	ENST00000664991.1	DLG1 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 1
chr14_-_20454741 Show fit	1.11	ENST00000206542.9 ENST00000553640.3	OSGEP Ensembl NCBI GeneCards UniProt Show fit	O-sialoglycoprotein endopeptidase
chr3_-_149221811 Show fit	1.08	ENST00000455472.3 ENST00000264613.11	CP Ensembl NCBI GeneCards UniProt Show fit	ceruloplasmin
chr3_+_183635605 Show fit	1.08	ENST00000493074.1 ENST00000437402.5 ENST00000454495.6 ENST00000473045.5 ENST00000468101.5 ENST00000427201.2 ENST00000482138.1 ENST00000454652.6 ENST00000242810.11	KLHL24 Ensembl NCBI GeneCards UniProt Show fit	kelch like family member 24
chr2_+_32063533 Show fit	1.07	ENST00000315285.9	SPAST Ensembl NCBI GeneCards UniProt Show fit	spastin
chr16_+_2770911 Show fit	1.05	ENST00000570539.1	SRRM2 Ensembl NCBI GeneCards UniProt Show fit	serine/arginine repetitive matrix 2
chr3_+_141387801 Show fit	1.05	ENST00000514251.5	ZBTB38 Ensembl NCBI GeneCards UniProt Show fit	zinc finger and BTB domain containing 38
chr3_+_52779916 Show fit	1.02	ENST00000537050.5	ITIH1 Ensembl NCBI GeneCards UniProt Show fit	inter-alpha-trypsin inhibitor heavy chain 1
chr2_-_207167220 Show fit	1.02	ENST00000421199.5 ENST00000457962.5	KLF7 Ensembl NCBI GeneCards UniProt Show fit	Kruppel like factor 7
chr10_+_113553039 Show fit	0.99	ENST00000351270.4	HABP2 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan binding protein 2
chr5_-_59039454 Show fit	0.98	ENST00000358923.10	PDE4D Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 4D
chr21_-_32771712 Show fit	0.97	ENST00000331923.9	PAXBP1 Ensembl NCBI GeneCards UniProt Show fit	PAX3 and PAX7 binding protein 1
chr16_-_73048104 Show fit	0.97	ENST00000268489.10	ZFHX3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger homeobox 3
chr12_-_48570046 Show fit	0.94	ENST00000301046.6 ENST00000549817.1	LALBA Ensembl NCBI GeneCards UniProt Show fit	lactalbumin alpha
chr8_+_22161788 Show fit	0.94	ENST00000521315.5 ENST00000437090.6 ENST00000679463.1 ENST00000520605.5 ENST00000522109.5 ENST00000524255.5 ENST00000523296.1	SFTPC Ensembl NCBI GeneCards UniProt Show fit	surfactant protein C
chr3_-_160565433 Show fit	0.93	ENST00000483437.2 ENST00000678765.1	KPNA4 Ensembl NCBI GeneCards UniProt Show fit	karyopherin subunit alpha 4
chr2_+_11539833 Show fit	0.93	ENST00000263834.9	GREB1 Ensembl NCBI GeneCards UniProt Show fit	growth regulating estrogen receptor binding 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
11.3	45.1	GO:0033606	B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
4.0	15.9	GO:1902544	regulation of DNA N-glycosylase activity(GO:1902544)
3.3	29.3	GO:2000332	response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
2.5	7.4	GO:0036333	hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
2.4	7.2	GO:0035574	histone H4-K20 demethylation(GO:0035574)
1.9	9.6	GO:1901202	negative regulation of extracellular matrix assembly(GO:1901202)
1.5	4.4	GO:1905000	regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.4	4.3	GO:0060392	negative regulation of SMAD protein import into nucleus(GO:0060392)
1.2	11.1	GO:0001661	conditioned taste aversion(GO:0001661)
1.2	21.2	GO:0017121	phospholipid scrambling(GO:0017121)
1.1	3.2	GO:0097698	telomere maintenance via base-excision repair(GO:0097698)
1.0	3.1	GO:0071484	response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) retinal cell apoptotic process(GO:1990009)
1.0	9.6	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.9	3.6	GO:0046833	positive regulation of RNA export from nucleus(GO:0046833)
0.9	6.1	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.9	5.2	GO:0035549	positive regulation of interferon-beta secretion(GO:0035549)
0.8	2.4	GO:0001544	initiation of primordial ovarian follicle growth(GO:0001544)
0.8	2.4	GO:0045360	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.6	1.9	GO:0002339	B cell selection(GO:0002339)
0.6	3.8	GO:0048619	embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619)
0.6	3.1	GO:0051799	negative regulation of hair follicle development(GO:0051799)
0.6	2.3	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
0.6	2.3	GO:0019418	sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.5	3.3	GO:0060368	negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.5	4.5	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.5	2.5	GO:0007386	compartment pattern specification(GO:0007386)
0.5	2.8	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.5	1.4	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996)
0.5	5.0	GO:0033327	Leydig cell differentiation(GO:0033327)
0.4	1.8	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.4	0.4	GO:0060197	cloacal septation(GO:0060197)
0.4	17.1	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.4	1.3	GO:0005988	lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.4	1.3	GO:0051228	mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.4	7.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4	4.6	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.4	2.1	GO:0006740	NADPH regeneration(GO:0006740)
0.4	2.4	GO:0006235	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.4	9.3	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.4	2.8	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.4	2.4	GO:0044211	CTP salvage(GO:0044211)
0.4	2.4	GO:0090625	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.4	3.5	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.4	1.1	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.4	3.3	GO:0031936	DNA replication-dependent nucleosome assembly(GO:0006335) negative regulation of chromatin silencing(GO:0031936) DNA replication-dependent nucleosome organization(GO:0034723)
0.4	1.4	GO:0097089	methyl-branched fatty acid metabolic process(GO:0097089)
0.4	1.4	GO:0000415	negative regulation of histone H3-K36 methylation(GO:0000415)
0.3	1.3	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3	2.2	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.3	1.5	GO:1904693	midbrain morphogenesis(GO:1904693)
0.3	3.2	GO:1904424	regulation of GTP binding(GO:1904424)
0.3	5.8	GO:0061436	establishment of skin barrier(GO:0061436)
0.3	4.7	GO:1902455	negative regulation of stem cell population maintenance(GO:1902455)
0.3	0.8	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3	6.4	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3	2.3	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.2	1.4	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.2	3.3	GO:0038203	TORC2 signaling(GO:0038203)
0.2	9.2	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2	1.8	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.2	9.6	GO:0048745	smooth muscle tissue development(GO:0048745)
0.2	3.2	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.2	4.2	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2	7.0	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.2	2.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.2	1.9	GO:0089700	protein kinase D signaling(GO:0089700)
0.2	4.0	GO:1900363	regulation of mRNA polyadenylation(GO:1900363)
0.2	3.3	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.2	1.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.2	1.5	GO:0007256	activation of JNKK activity(GO:0007256)
0.2	1.7	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2	17.1	GO:0045454	cell redox homeostasis(GO:0045454)
0.2	3.5	GO:0015671	oxygen transport(GO:0015671)
0.2	18.0	GO:0002181	cytoplasmic translation(GO:0002181)
0.2	3.6	GO:0006853	carnitine shuttle(GO:0006853)
0.2	1.3	GO:1902414	protein localization to cell junction(GO:1902414)
0.2	2.0	GO:0000722	telomere maintenance via recombination(GO:0000722)
0.1	1.8	GO:0052696	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1	4.0	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	4.2	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1	7.3	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1	1.2	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1	3.6	GO:0045577	regulation of B cell differentiation(GO:0045577)
0.1	1.2	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.1	2.7	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.1	3.2	GO:0009649	entrainment of circadian clock(GO:0009649)
0.1	1.0	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1	0.4	GO:1904885	beta-catenin destruction complex assembly(GO:1904885)
0.1	2.9	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	1.2	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1	4.2	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1	0.3	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.1	2.3	GO:0042953	vitamin D metabolic process(GO:0042359) lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1	0.8	GO:0043589	skin morphogenesis(GO:0043589)
0.1	4.7	GO:0007194	negative regulation of adenylate cyclase activity(GO:0007194)
0.1	0.6	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.1	2.9	GO:0006337	nucleosome disassembly(GO:0006337)
0.1	14.7	GO:0006261	DNA-dependent DNA replication(GO:0006261)
0.1	0.5	GO:1903232	melanosome assembly(GO:1903232)
0.1	9.5	GO:0070268	cornification(GO:0070268)
0.1	3.6	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.1	2.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.1	0.3	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.1	0.5	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.1	1.7	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.1	0.6	GO:0044334	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1	0.4	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1	5.9	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.1	1.7	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.1	12.3	GO:0001837	epithelial to mesenchymal transition(GO:0001837)
0.1	1.1	GO:0045109	intermediate filament organization(GO:0045109)
0.1	0.6	GO:0070842	aggresome assembly(GO:0070842)
0.1	1.9	GO:0015695	organic cation transport(GO:0015695)
0.1	3.2	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	1.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	3.9	GO:0014823	response to activity(GO:0014823)
0.0	0.3	GO:2000288	positive regulation of myoblast proliferation(GO:2000288)
0.0	1.1	GO:0006825	copper ion transport(GO:0006825)
0.0	1.3	GO:0043029	T cell homeostasis(GO:0043029)
0.0	0.1	GO:0001188	RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0	3.5	GO:0048706	embryonic skeletal system development(GO:0048706)
0.0	0.4	GO:0021840	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0	0.1	GO:0036058	filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0	0.6	GO:0031424	keratinization(GO:0031424)
0.0	15.7	GO:0042493	response to drug(GO:0042493)
0.0	2.2	GO:0007585	respiratory gaseous exchange(GO:0007585)
0.0	0.4	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	1.7	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.3	GO:0045821	positive regulation of glycolytic process(GO:0045821)
0.0	0.4	GO:0040018	positive regulation of multicellular organism growth(GO:0040018)
0.0	1.5	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.3	GO:0043536	positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0	0.3	GO:0009303	rRNA transcription(GO:0009303)
0.0	0.3	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.2	GO:0003301	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.7	14.0	GO:0008623	CHRAC(GO:0008623)
2.2	6.7	GO:0005600	collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
1.9	45.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
1.9	9.3	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
1.4	11.1	GO:0035976	AP1 complex(GO:0035976)
1.0	5.2	GO:0005726	perichromatin fibrils(GO:0005726)
0.9	34.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.9	6.4	GO:0044530	supraspliceosomal complex(GO:0044530)
0.9	4.5	GO:0042025	host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.9	4.4	GO:0031523	Myb complex(GO:0031523)
0.5	2.0	GO:0035061	Smc5-Smc6 complex(GO:0030915) interchromatin granule(GO:0035061)
0.5	7.7	GO:0045120	pronucleus(GO:0045120)
0.4	13.3	GO:0071564	npBAF complex(GO:0071564)
0.4	4.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.3	2.8	GO:0031414	N-terminal protein acetyltransferase complex(GO:0031414)
0.3	2.4	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.3	1.7	GO:0005816	spindle pole body(GO:0005816)
0.3	2.4	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.3	6.5	GO:0042588	zymogen granule(GO:0042588)
0.2	3.5	GO:0005833	hemoglobin complex(GO:0005833)
0.2	1.1	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.2	1.3	GO:0032584	growth cone membrane(GO:0032584)
0.2	0.7	GO:0097135	cyclin E2-CDK2 complex(GO:0097135)
0.2	9.6	GO:0031258	lamellipodium membrane(GO:0031258)
0.2	5.5	GO:0032982	myosin filament(GO:0032982)
0.2	3.3	GO:0031932	TORC2 complex(GO:0031932)
0.2	2.2	GO:0097486	multivesicular body lumen(GO:0097486)
0.2	3.6	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.2	18.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.2	1.9	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.2	3.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.2	4.0	GO:0005685	U1 snRNP(GO:0005685)
0.1	5.8	GO:0009925	basal plasma membrane(GO:0009925)
0.1	3.8	GO:0005719	nuclear euchromatin(GO:0005719)
0.1	2.9	GO:0030056	hemidesmosome(GO:0030056)
0.1	16.5	GO:0016605	PML body(GO:0016605)
0.1	1.9	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.1	0.5	GO:0031905	early endosome lumen(GO:0031905)
0.1	4.2	GO:1902711	GABA-A receptor complex(GO:1902711)
0.1	1.3	GO:0000815	ESCRT III complex(GO:0000815)
0.1	2.9	GO:0030057	desmosome(GO:0030057)
0.1	1.7	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	17.1	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.1	0.9	GO:0005638	lamin filament(GO:0005638)
0.1	9.0	GO:0005882	intermediate filament(GO:0005882)
0.1	4.0	GO:0001917	photoreceptor inner segment(GO:0001917)
0.1	3.3	GO:0001772	immunological synapse(GO:0001772)
0.1	3.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	8.0	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.1	0.8	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	1.4	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	3.8	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	2.3	GO:0031526	brush border membrane(GO:0031526)
0.0	4.1	GO:0005643	nuclear pore(GO:0005643)
0.0	7.7	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	1.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	2.2	GO:0035097	histone methyltransferase complex(GO:0035097)
0.0	3.6	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	12.6	GO:0005667	transcription factor complex(GO:0005667)
0.0	8.8	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	0.4	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	1.0	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	2.9	GO:0034399	nuclear periphery(GO:0034399)
0.0	2.1	GO:0005746	mitochondrial respiratory chain(GO:0005746)
0.0	1.1	GO:0015030	Cajal body(GO:0015030)
0.0	3.3	GO:0042383	sarcolemma(GO:0042383)
0.0	9.7	GO:0005925	focal adhesion(GO:0005925)
0.0	2.1	GO:0005681	spliceosomal complex(GO:0005681)
0.0	0.5	GO:0005921	gap junction(GO:0005921)
0.0	0.6	GO:0016235	aggresome(GO:0016235)
0.0	6.0	GO:0016607	nuclear speck(GO:0016607)
0.0	3.3	GO:0000790	nuclear chromatin(GO:0000790)
0.0	1.4	GO:0005604	basement membrane(GO:0005604)
0.0	0.6	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0	0.3	GO:0036064	ciliary basal body(GO:0036064)
0.0	0.3	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.4	GO:0030673	axolemma(GO:0030673)
0.0	6.1	GO:0005813	centrosome(GO:0005813)
0.0	1.4	GO:0031901	early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.3	15.9	GO:0043739	G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
3.7	29.3	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
2.4	7.2	GO:0035575	histone demethylase activity (H4-K20 specific)(GO:0035575)
1.3	9.3	GO:0030369	ICAM-3 receptor activity(GO:0030369)
1.3	21.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
1.3	5.2	GO:0033677	DNA/RNA helicase activity(GO:0033677)
1.3	3.8	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
1.2	45.5	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
1.0	4.0	GO:0002046	opsin binding(GO:0002046)
0.9	4.4	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.9	17.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.8	4.0	GO:0035614	snRNA stem-loop binding(GO:0035614)
0.8	3.2	GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.8	2.4	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.8	2.3	GO:0015140	malate transmembrane transporter activity(GO:0015140)
0.7	7.4	GO:0070878	primary miRNA binding(GO:0070878)
0.7	21.2	GO:0070410	co-SMAD binding(GO:0070410)
0.7	3.3	GO:0047280	nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.6	1.9	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.6	2.3	GO:0016524	latrotoxin receptor activity(GO:0016524)
0.6	12.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.6	2.3	GO:0042954	lipoprotein transporter activity(GO:0042954)
0.5	9.6	GO:0045294	alpha-catenin binding(GO:0045294)
0.4	5.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4	3.5	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.4	1.5	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.4	4.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.3	2.4	GO:0004849	uridine kinase activity(GO:0004849)
0.3	3.6	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.3	4.5	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.3	4.7	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.3	8.2	GO:0070064	proline-rich region binding(GO:0070064)
0.3	8.5	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.3	2.3	GO:0048495	Roundabout binding(GO:0048495)
0.3	4.3	GO:0001222	transcription corepressor binding(GO:0001222)
0.2	2.2	GO:1990226	histone methyltransferase binding(GO:1990226)
0.2	1.7	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2	0.9	GO:0004461	lactose synthase activity(GO:0004461)
0.2	1.2	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.2	3.5	GO:0005344	oxygen transporter activity(GO:0005344)
0.2	11.1	GO:0070412	R-SMAD binding(GO:0070412)
0.2	2.8	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2	13.5	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.2	1.9	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.2	1.3	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.2	1.2	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.2	3.1	GO:0097016	L27 domain binding(GO:0097016)
0.2	7.0	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.1	1.5	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.1	0.3	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.1	6.9	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.1	0.6	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1	1.9	GO:0019534	toxin transporter activity(GO:0019534)
0.1	1.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	1.9	GO:0004559	alpha-mannosidase activity(GO:0004559)
0.1	2.7	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.1	3.6	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	2.1	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.1	1.4	GO:0039706	co-receptor binding(GO:0039706)
0.1	1.3	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1	1.7	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	2.4	GO:0035198	miRNA binding(GO:0035198)
0.1	0.3	GO:0004382	guanosine-diphosphatase activity(GO:0004382)
0.1	2.3	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	14.1	GO:0042826	histone deacetylase binding(GO:0042826)
0.1	0.3	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.4	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1	1.9	GO:0051400	BH domain binding(GO:0051400)
0.1	1.3	GO:0046790	virion binding(GO:0046790)
0.1	1.2	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.1	4.7	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.1	1.4	GO:0015245	fatty acid transporter activity(GO:0015245)
0.1	2.9	GO:0030506	ankyrin binding(GO:0030506)
0.1	1.9	GO:0004697	protein kinase C activity(GO:0004697)
0.1	3.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	18.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	9.6	GO:0005518	collagen binding(GO:0005518)
0.1	2.4	GO:0001221	transcription cofactor binding(GO:0001221)
0.1	0.8	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	1.8	GO:0031489	myosin V binding(GO:0031489)
0.1	1.7	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	13.1	GO:0001047	core promoter binding(GO:0001047)
0.1	2.2	GO:0004890	GABA-A receptor activity(GO:0004890)
0.1	0.4	GO:0019826	oxygen sensor activity(GO:0019826)
0.1	1.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	1.7	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1	1.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.1	3.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.6	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	0.4	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.1	0.3	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.1	1.8	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.0	5.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.8	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	1.0	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	2.1	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	3.9	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.6	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.7	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.9	GO:0005521	lamin binding(GO:0005521)
0.0	3.2	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.0	1.3	GO:0042169	SH2 domain binding(GO:0042169)
0.0	2.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0	3.9	GO:0008201	heparin binding(GO:0008201)
0.0	2.1	GO:0050661	NADP binding(GO:0050661)
0.0	1.7	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.5	GO:0005522	profilin binding(GO:0005522)
0.0	0.9	GO:0050699	WW domain binding(GO:0050699)
0.0	1.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.4	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.6	GO:0070628	proteasome binding(GO:0070628)
0.0	0.5	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.6	GO:0005523	tropomyosin binding(GO:0005523)
0.0	3.6	GO:0042393	histone binding(GO:0042393)
0.0	4.8	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.0	2.2	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.3	GO:0031996	thioesterase binding(GO:0031996)
0.0	1.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	7.1	GO:0045296	cadherin binding(GO:0045296)
0.0	0.5	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.1	GO:0005497	androgen binding(GO:0005497)
0.0	1.0	GO:0005539	glycosaminoglycan binding(GO:0005539)
0.0	3.5	GO:0003713	transcription coactivator activity(GO:0003713)
0.0	6.7	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	2.9	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	11.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	9.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.4	15.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.3	3.5	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.3	5.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	14.1	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.2	4.6	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	4.0	PID CONE PATHWAY	Visual signal transduction: Cones
0.2	21.2	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.2	6.5	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	10.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	4.1	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	11.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	3.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	4.0	PID MYC PATHWAY	C-MYC pathway
0.1	5.1	NABA COLLAGENS	Genes encoding collagen proteins
0.1	2.8	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	1.9	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	2.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	2.2	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	3.6	PID IL2 1PATHWAY	IL2-mediated signaling events
0.1	4.9	PID FOXO PATHWAY	FoxO family signaling
0.1	3.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	4.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	3.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	0.7	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	1.9	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	3.6	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	1.5	PID IFNG PATHWAY	IFN-gamma pathway
0.0	8.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.9	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	14.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	1.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	1.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.8	PID E2F PATHWAY	E2F transcription factor network
0.0	1.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.9	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	3.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.0	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.4	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.6	PID AP1 PATHWAY	AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	19.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.4	11.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.4	21.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3	29.3	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.3	3.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.3	3.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.2	7.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.2	6.8	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.2	3.5	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.2	4.8	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.2	32.7	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.2	3.6	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2	4.7	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.2	4.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	3.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	2.9	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1	3.4	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	4.5	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	1.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	18.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	9.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	2.4	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	15.6	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	3.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	2.9	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	4.2	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.1	0.8	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	2.2	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.1	2.1	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.1	1.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	2.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	1.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	5.8	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	4.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	2.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	1.9	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.1	0.7	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.1	2.1	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	2.2	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	2.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.9	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.6	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	3.5	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.4	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	5.5	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.0	0.5	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis

Results for TCF7L1

Z-value: 1.14

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Transcription factors associated with TCF7L1

Activity-expression correlation:

Activity profile of TCF7L1 motif

Sorted Z-values of TCF7L1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: