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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TFAP2C
Z-value: 10.29
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Transcription factors associated with TFAP2C
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2C | hg38_v1_chr20_+_56629296_56629321 | -0.37 | 2.1e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2C
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_172869 Show fit | 51.02 |
ENST00000251595.11
ENST00000397806.1 ENST00000484216.1 |
hemoglobin subunit alpha 2 |
|
| chr6_+_33075952 Show fit | 32.05 |
ENST00000418931.7
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr21_-_44928824 Show fit | 28.26 |
ENST00000355153.8
ENST00000397850.6 |
integrin subunit beta 2 |
|
| chr14_+_92323154 Show fit | 26.09 |
ENST00000532405.6
ENST00000676001.1 ENST00000531433.5 |
solute carrier family 24 member 4 |
|
| chr16_+_176659 Show fit | 24.91 |
ENST00000320868.9
ENST00000397797.1 |
hemoglobin subunit alpha 1 |
|
| chr16_+_85027761 Show fit | 22.55 |
ENST00000683363.1
|
KIAA0513 |
|
| chr9_-_133992312 Show fit | 20.92 |
ENST00000371850.8
|
vav guanine nucleotide exchange factor 2 |
|
| chr15_-_64046322 Show fit | 19.27 |
ENST00000457488.5
ENST00000612884.4 |
death associated protein kinase 2 |
|
| chr10_+_86968432 Show fit | 19.11 |
ENST00000416348.1
ENST00000372013.8 |
adipogenesis regulatory factor |
|
| chr9_-_96655280 Show fit | 18.94 |
ENST00000446045.1
ENST00000375234.8 |
peroxiredoxin like 2C |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 146.1 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 1.0 | 89.3 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 8.4 | 67.3 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 2.4 | 50.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 1.5 | 47.0 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 2.3 | 44.6 | GO:0097320 | membrane tubulation(GO:0097320) |
| 2.1 | 44.3 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 1.0 | 43.1 | GO:0060119 | inner ear receptor cell development(GO:0060119) |
| 0.6 | 42.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.0 | 38.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 148.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 2.1 | 71.0 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.2 | 56.2 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 2.1 | 54.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.4 | 51.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.4 | 48.0 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 2.4 | 46.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 45.6 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.3 | 42.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.8 | 40.2 | GO:0042571 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 256.0 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.4 | 106.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.6 | 90.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 16.8 | 67.3 | GO:0008832 | dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793) guanyl deoxyribonucleotide binding(GO:0032560) dGTP binding(GO:0032567) |
| 0.6 | 60.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.2 | 59.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 1.1 | 54.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 2.6 | 54.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 1.4 | 45.2 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 2.3 | 44.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 164.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 1.5 | 52.6 | PID EPO PATHWAY | EPO signaling pathway |
| 0.8 | 44.2 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.9 | 43.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.6 | 40.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.5 | 34.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.5 | 29.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.9 | 28.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.4 | 27.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.8 | 26.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 76.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.0 | 59.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.6 | 57.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.9 | 46.6 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 2.1 | 41.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.6 | 38.5 | REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism |
| 0.8 | 34.4 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.9 | 34.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.7 | 33.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 1.7 | 32.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |