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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TFAP2E

Z-value: 2.60

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.9 TFAP2E

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_82901698 11.12 ENST00000524921.5
ENST00000528759.5
ENST00000525361.5
ENST00000532764.5
ENST00000532589.5
ENST00000533655.6
ENST00000525388.5
DDIAS
DNA damage induced apoptosis suppressor
chr17_-_44915486 10.09 ENST00000638281.1
ENST00000588316.1
ENST00000588735.3
ENST00000639277.1
ENST00000253408.11
ENST00000435360.8
ENST00000586793.6
ENST00000588037.1
ENST00000592320.6
GFAP
glial fibrillary acidic protein
chr16_+_56589521 8.83 ENST00000200691.5
ENST00000570176.1
MT3
metallothionein 3
chr1_-_11805977 8.05 ENST00000376486.3
MTHFR
methylenetetrahydrofolate reductase
chr1_-_11805924 7.57 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase
chr12_+_75391078 7.04 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1L2
GLIPR1 like 2
chr1_-_11805949 7.00 ENST00000376590.9
MTHFR
methylenetetrahydrofolate reductase
chr15_+_23565705 6.19 ENST00000568252.1
ENST00000649065.1
MKRN3
makorin ring finger protein 3
chr6_+_42564060 6.06 ENST00000372903.6
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr7_-_45088888 5.73 ENST00000490531.3
NACAD
NAC alpha domain containing
chr6_-_29633171 5.55 ENST00000377034.9
GABBR1
gamma-aminobutyric acid type B receptor subunit 1
chr6_-_29633056 5.51 ENST00000377016.8
GABBR1
gamma-aminobutyric acid type B receptor subunit 1
chr7_+_73433761 5.07 ENST00000344575.5
FZD9
frizzled class receptor 9
chr17_-_76726753 4.98 ENST00000617192.4
JMJD6
jumonji domain containing 6, arginine demethylase and lysine hydroxylase
chr1_+_8945858 4.91 ENST00000549778.5
ENST00000377443.7
ENST00000480186.7
ENST00000377436.6
ENST00000377442.3
CA6
carbonic anhydrase 6
chr14_+_24368020 4.82 ENST00000554050.5
ENST00000554903.1
ENST00000250373.9
ENST00000554779.1
ENST00000553708.5
NFATC4
nuclear factor of activated T cells 4
chr19_+_4969105 4.79 ENST00000611640.4
ENST00000159111.9
ENST00000588337.5
ENST00000381759.8
KDM4B
lysine demethylase 4B
chr3_+_49554436 4.65 ENST00000296452.5
BSN
bassoon presynaptic cytomatrix protein
chr3_+_4493442 4.65 ENST00000456211.8
ENST00000443694.5
ENST00000648266.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chrX_+_153724847 4.62 ENST00000218104.6
ABCD1
ATP binding cassette subfamily D member 1
chr3_+_4493340 4.51 ENST00000357086.10
ENST00000354582.12
ENST00000649015.2
ENST00000467056.6
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr17_+_3723889 4.50 ENST00000325418.5
HASPIN
histone H3 associated protein kinase
chr3_+_4493471 4.45 ENST00000544951.6
ENST00000650294.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr3_-_48088800 3.79 ENST00000423088.5
MAP4
microtubule associated protein 4
chr4_-_81471855 3.79 ENST00000436139.6
ENST00000613784.1
RASGEF1B
RasGEF domain family member 1B
chr17_-_38799442 3.71 ENST00000619039.5
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
chr19_-_45886120 3.39 ENST00000302165.5
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr10_+_98134642 3.32 ENST00000298999.8
R3HCC1L
R3H domain and coiled-coil containing 1 like
chr18_-_76495191 3.29 ENST00000443185.7
ZNF516
zinc finger protein 516
chr2_+_218859794 3.26 ENST00000233948.4
WNT6
Wnt family member 6
chr10_+_98134622 3.21 ENST00000370584.7
R3HCC1L
R3H domain and coiled-coil containing 1 like
chr2_+_73202570 3.20 ENST00000398468.4
NOTO
notochord homeobox
chr22_+_39994926 3.14 ENST00000333407.11
FAM83F
family with sequence similarity 83 member F
chr15_-_52528870 3.13 ENST00000399233.7
ENST00000356338.10
MYO5A
myosin VA
chr20_+_24469623 3.13 ENST00000376862.4
SYNDIG1
synapse differentiation inducing 1
chr7_+_29194757 3.12 ENST00000222792.11
CHN2
chimerin 2
chr7_-_140924699 3.10 ENST00000288602.11
ENST00000469930.2
ENST00000496384.7
BRAF
B-Raf proto-oncogene, serine/threonine kinase
chr15_-_65211463 3.09 ENST00000261883.6
CILP
cartilage intermediate layer protein
chr11_-_47848539 3.04 ENST00000526870.1
NUP160
nucleoporin 160
chr11_-_35419213 3.02 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
SLC1A2
solute carrier family 1 member 2
chr7_+_35800932 3.01 ENST00000635172.1
ENST00000399034.7
ENST00000350320.10
ENST00000435235.6
ENST00000672279.1
ENST00000634600.1
ENST00000635047.1
SEPTIN7
septin 7
chr12_+_53050179 2.96 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
TNS2
tensin 2
chr11_-_35419542 2.94 ENST00000643305.1
ENST00000644351.1
ENST00000278379.9
ENST00000644779.1
SLC1A2
solute carrier family 1 member 2
chr8_-_126557691 2.81 ENST00000652209.1
LRATD2
LRAT domain containing 2
chr8_+_17922974 2.74 ENST00000517730.5
ENST00000518537.5
ENST00000523055.5
ENST00000519253.5
PCM1
pericentriolar material 1
chr8_+_25184668 2.72 ENST00000276440.12
ENST00000410074.5
DOCK5
dedicator of cytokinesis 5
chr13_+_19958760 2.69 ENST00000382871.3
ZMYM2
zinc finger MYM-type containing 2
chr13_+_19958708 2.65 ENST00000382874.6
ENST00000610343.5
ZMYM2
zinc finger MYM-type containing 2
chr1_+_17308194 2.64 ENST00000375453.5
ENST00000375448.4
PADI4
peptidyl arginine deiminase 4
chr3_+_156142962 2.60 ENST00000471742.5
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr4_-_2262082 2.58 ENST00000337190.7
MXD4
MAX dimerization protein 4
chr2_+_38666059 2.58 ENST00000272252.10
ENST00000410063.5
GALM
galactose mutarotase
chr17_+_30831944 2.57 ENST00000321990.5
ATAD5
ATPase family AAA domain containing 5
chr11_-_35419462 2.50 ENST00000643522.1
SLC1A2
solute carrier family 1 member 2
chr6_+_31586859 2.45 ENST00000433492.5
LST1
leukocyte specific transcript 1
chr7_-_140924900 2.43 ENST00000646891.1
ENST00000644969.2
BRAF
B-Raf proto-oncogene, serine/threonine kinase
chr9_+_4985227 2.41 ENST00000381652.4
JAK2
Janus kinase 2
chr13_-_26760741 2.39 ENST00000405846.5
GPR12
G protein-coupled receptor 12
chr11_-_35419098 2.39 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2
chr19_-_43465596 2.30 ENST00000244333.4
LYPD3
LY6/PLAUR domain containing 3
chr6_+_42563981 2.23 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr4_-_152679984 2.18 ENST00000304385.8
ENST00000504064.1
TMEM154
transmembrane protein 154
chr9_-_34662654 2.12 ENST00000259631.5
CCL27
C-C motif chemokine ligand 27
chr13_-_75482114 2.12 ENST00000377625.6
ENST00000431480.6
TBC1D4
TBC1 domain family member 4
chr6_+_7107597 2.00 ENST00000379933.7
ENST00000491191.5
ENST00000471433.5
RREB1
ras responsive element binding protein 1
chr10_+_91220603 2.00 ENST00000336126.6
PCGF5
polycomb group ring finger 5
chr13_-_75482151 1.97 ENST00000377636.8
TBC1D4
TBC1 domain family member 4
chr6_+_13272709 1.96 ENST00000379335.8
PHACTR1
phosphatase and actin regulator 1
chr12_-_14567714 1.94 ENST00000240617.10
PLBD1
phospholipase B domain containing 1
chr17_-_41612757 1.93 ENST00000301653.9
ENST00000593067.1
KRT16
keratin 16
chr19_+_8390316 1.84 ENST00000328024.11
ENST00000601897.1
ENST00000594216.1
RAB11B
RAB11B, member RAS oncogene family
chr19_-_38773432 1.83 ENST00000599035.1
ENST00000378626.5
LGALS7
galectin 7
chr1_-_201377652 1.80 ENST00000455702.6
ENST00000367320.6
ENST00000421663.6
ENST00000412633.3
ENST00000367318.10
ENST00000422165.6
ENST00000656932.1
ENST00000438742.6
ENST00000367322.6
ENST00000458432.6
ENST00000509001.5
ENST00000660295.1
TNNT2
troponin T2, cardiac type
chr7_-_100468063 1.78 ENST00000423266.5
ENST00000456330.1
TSC22D4
TSC22 domain family member 4
chr9_-_21077938 1.78 ENST00000380232.4
IFNB1
interferon beta 1
chr14_+_103385374 1.77 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
MARK3
microtubule affinity regulating kinase 3
chr1_-_114511160 1.71 ENST00000369543.6
ENST00000358465.7
TRIM33
tripartite motif containing 33
chr19_+_45001430 1.68 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB
RELB proto-oncogene, NF-kB subunit
chr7_-_23014099 1.65 ENST00000432176.7
ENST00000440481.6
FAM126A
family with sequence similarity 126 member A
chr3_-_136752361 1.64 ENST00000480733.1
ENST00000629124.2
ENST00000383202.7
ENST00000236698.9
ENST00000434713.6
STAG1
stromal antigen 1
chr6_+_31586835 1.60 ENST00000211921.11
LST1
leukocyte specific transcript 1
chr8_+_17922837 1.60 ENST00000325083.12
PCM1
pericentriolar material 1
chr5_+_134648772 1.59 ENST00000398844.7
ENST00000322887.8
SEC24A
SEC24 homolog A, COPII coat complex component
chr11_-_35420017 1.58 ENST00000643000.1
ENST00000646099.1
ENST00000647372.1
ENST00000642578.1
SLC1A2
solute carrier family 1 member 2
chr19_+_35704540 1.58 ENST00000392197.7
ENST00000426659.6
ZBTB32
zinc finger and BTB domain containing 32
chr14_+_103385450 1.51 ENST00000416682.6
MARK3
microtubule affinity regulating kinase 3
chr19_+_50432885 1.42 ENST00000357701.6
MYBPC2
myosin binding protein C2
chr19_+_49157780 1.41 ENST00000599628.5
ENST00000252826.10
ENST00000427978.6
TRPM4
transient receptor potential cation channel subfamily M member 4
chr10_-_110919146 1.40 ENST00000652396.1
ENST00000423273.5
ENST00000436562.1
ENST00000651952.1
ENST00000448814.7
ENST00000652400.1
ENST00000447005.5
ENST00000454061.5
BBIP1
BBSome interacting protein 1
chr2_+_6917404 1.38 ENST00000320892.11
RNF144A
ring finger protein 144A
chr11_-_66289007 1.34 ENST00000431556.6
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A, membrane trafficking protein
chr9_+_126326809 1.33 ENST00000361171.8
ENST00000489637.3
MVB12B
multivesicular body subunit 12B
chr5_+_177133005 1.27 ENST00000510954.5
ENST00000354179.8
NSD1
nuclear receptor binding SET domain protein 1
chr10_-_96513911 1.26 ENST00000357947.4
TLL2
tolloid like 2
chr11_+_118607579 1.26 ENST00000530708.4
PHLDB1
pleckstrin homology like domain family B member 1
chr11_+_116829898 1.25 ENST00000227667.8
ENST00000375345.3
APOC3
apolipoprotein C3
chr4_+_153466324 1.24 ENST00000409663.7
ENST00000409959.8
TMEM131L
transmembrane 131 like
chr14_+_20745880 1.20 ENST00000326842.3
EDDM3A
epididymal protein 3A
chr7_+_32495447 1.20 ENST00000318709.9
ENST00000409301.5
ENST00000640103.1
AVL9
AVL9 cell migration associated
chrX_+_129738942 1.19 ENST00000371106.4
XPNPEP2
X-prolyl aminopeptidase 2
chr3_+_52779916 1.18 ENST00000537050.5
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr3_-_48088824 1.17 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
MAP4
microtubule associated protein 4
chr20_+_19212624 1.15 ENST00000328041.11
SLC24A3
solute carrier family 24 member 3
chr17_-_35089212 1.14 ENST00000584655.5
ENST00000447669.6
ENST00000315249.11
RFFL
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr5_-_180072086 1.11 ENST00000261947.4
RNF130
ring finger protein 130
chr11_+_118607598 1.10 ENST00000600882.6
ENST00000356063.9
PHLDB1
pleckstrin homology like domain family B member 1
chr2_-_177264686 1.05 ENST00000397062.8
ENST00000430047.1
NFE2L2
nuclear factor, erythroid 2 like 2
chr3_+_50155305 1.04 ENST00000002829.8
ENST00000426511.5
SEMA3F
semaphorin 3F
chr20_+_2840694 1.03 ENST00000380469.7
ENST00000380445.8
ENST00000453689.5
ENST00000417508.1
VPS16
VPS16 core subunit of CORVET and HOPS complexes
chr1_+_3069195 0.96 ENST00000378391.6
ENST00000270722.10
ENST00000514189.5
PRDM16
PR/SET domain 16
chr6_+_31586680 0.91 ENST00000339530.8
LST1
leukocyte specific transcript 1
chr5_-_151924846 0.91 ENST00000274576.9
GLRA1
glycine receptor alpha 1
chr2_-_240892007 0.90 ENST00000402775.6
ENST00000307486.12
MAB21L4
mab-21 like 4
chr10_-_77637902 0.86 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr5_-_180071708 0.83 ENST00000522208.6
ENST00000521389.6
RNF130
ring finger protein 130
chr5_-_151924824 0.80 ENST00000455880.2
GLRA1
glycine receptor alpha 1
chr9_+_133636355 0.79 ENST00000393056.8
DBH
dopamine beta-hydroxylase
chr19_+_3572777 0.77 ENST00000416526.5
HMG20B
high mobility group 20B
chrX_-_49079702 0.76 ENST00000636049.1
ENST00000474053.6
ENST00000635003.1
WDR45
WD repeat domain 45
chr11_+_3855629 0.75 ENST00000526596.2
ENST00000300737.8
ENST00000616714.4
STIM1
stromal interaction molecule 1
chr10_-_77638369 0.74 ENST00000372443.6
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr14_+_103385506 0.72 ENST00000303622.13
MARK3
microtubule affinity regulating kinase 3
chr11_-_47848313 0.72 ENST00000530326.5
ENST00000528071.5
NUP160
nucleoporin 160
chr11_-_71252492 0.69 ENST00000601538.6
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr9_+_35605234 0.61 ENST00000336395.6
TESK1
testis associated actin remodelling kinase 1
chr2_+_74514442 0.59 ENST00000233638.8
TLX2
T cell leukemia homeobox 2
chr11_-_82901654 0.56 ENST00000534631.5
ENST00000531801.6
ENST00000680524.1
ENST00000531128.5
ENST00000680566.1
PRCP
prolylcarboxypeptidase
chr11_-_82901623 0.52 ENST00000681637.1
ENST00000679387.1
PRCP
prolylcarboxypeptidase
chr16_+_69566041 0.51 ENST00000567239.5
NFAT5
nuclear factor of activated T cells 5
chr11_-_82901594 0.45 ENST00000679623.1
PRCP
prolylcarboxypeptidase
chr8_+_124450806 0.45 ENST00000328599.4
TRMT12
tRNA methyltransferase 12 homolog
chr1_-_85048437 0.44 ENST00000341115.8
ENST00000370587.5
ENST00000370589.7
MCOLN3
mucolipin TRP cation channel 3
chr2_-_23927107 0.39 ENST00000238789.10
ATAD2B
ATPase family AAA domain containing 2B
chr14_-_25049889 0.38 ENST00000419632.6
ENST00000396700.5
STXBP6
syntaxin binding protein 6
chr4_-_100517991 0.37 ENST00000511970.5
ENST00000502569.1
ENST00000305864.7
ENST00000296420.9
EMCN
endomucin
chr14_-_25050111 0.30 ENST00000323944.9
STXBP6
syntaxin binding protein 6
chr3_+_53161120 0.28 ENST00000394729.6
ENST00000330452.8
ENST00000652449.1
PRKCD
protein kinase C delta
chr9_+_35605277 0.28 ENST00000620767.4
TESK1
testis associated actin remodelling kinase 1
chrX_+_116436599 0.22 ENST00000598581.3
SLC6A14
solute carrier family 6 member 14
chr17_+_76074772 0.21 ENST00000329003.4
GALR2
galanin receptor 2
chr15_+_84817346 0.16 ENST00000258888.6
ALPK3
alpha kinase 3
chr10_-_124092445 0.14 ENST00000346248.7
CHST15
carbohydrate sulfotransferase 15
chr11_-_47848467 0.09 ENST00000378460.6
NUP160
nucleoporin 160
chr19_+_43576800 0.08 ENST00000612042.4
PINLYP
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr1_-_113812448 0.06 ENST00000612242.4
ENST00000261441.9
RSBN1
round spermatid basic protein 1
chr17_+_39668447 0.05 ENST00000269582.3
ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr4_+_41990496 0.05 ENST00000264451.12
SLC30A9
solute carrier family 30 member 9
chr11_-_35419899 0.04 ENST00000646847.1
ENST00000449068.2
ENST00000643401.1
ENST00000645966.1
ENST00000647104.1
SLC1A2
solute carrier family 1 member 2
chr20_+_6767678 0.02 ENST00000378827.5
BMP2
bone morphogenetic protein 2
chr2_-_37324826 0.01 ENST00000234179.8
PRKD3
protein kinase D3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 22.6 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
2.9 8.8 GO:2000296 lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
1.7 13.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.7 5.1 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
1.7 5.0 GO:0070079 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine(GO:0018395) histone arginine demethylation(GO:0070077) histone H3-R2 demethylation(GO:0070078) histone H4-R3 demethylation(GO:0070079)
1.7 8.3 GO:0071233 cellular response to leucine(GO:0071233)
1.6 4.7 GO:0099526 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
1.2 4.8 GO:2000297 negative regulation of synapse maturation(GO:2000297)
1.2 4.6 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.9 5.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.9 2.6 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.8 12.5 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.8 5.0 GO:0051012 microtubule sliding(GO:0051012)
0.8 2.4 GO:0060398 mineralocorticoid receptor signaling pathway(GO:0031959) regulation of growth hormone receptor signaling pathway(GO:0060398) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.7 4.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.7 2.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.6 3.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.6 4.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.5 2.7 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.5 3.3 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.5 10.1 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.5 1.4 GO:1903781 positive regulation of cardiac conduction(GO:1903781)
0.5 1.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.4 1.3 GO:0019075 virus maturation(GO:0019075)
0.4 4.0 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.4 1.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.4 3.7 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.3 4.8 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.3 1.2 GO:2000909 regulation of high-density lipoprotein particle clearance(GO:0010982) regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.3 3.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 1.1 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.3 1.3 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.2 1.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 11.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 1.8 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 2.4 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.2 1.8 GO:0045054 constitutive secretory pathway(GO:0045054)
0.2 1.8 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.2 1.5 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.2 1.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 4.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.7 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.2 1.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.2 3.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.2 2.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 1.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 2.6 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 1.0 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 1.2 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 1.6 GO:0045794 response to carbon monoxide(GO:0034465) negative regulation of cell volume(GO:0045794)
0.1 3.2 GO:0044458 motile cilium assembly(GO:0044458)
0.1 1.9 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 0.8 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.1 1.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 3.0 GO:0014850 response to muscle activity(GO:0014850)
0.1 0.3 GO:2000754 regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755)
0.1 1.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.7 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 1.4 GO:0051546 keratinocyte migration(GO:0051546)
0.1 1.2 GO:0007320 insemination(GO:0007320)
0.1 2.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 3.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.8 GO:0044804 nucleophagy(GO:0044804)
0.0 3.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 1.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.6 GO:0048484 enteric nervous system development(GO:0048484)
0.0 10.5 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.5 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 1.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.7 GO:0060292 long term synaptic depression(GO:0060292)
0.0 1.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 1.7 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.0 6.2 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 0.4 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.0 1.6 GO:0007062 sister chromatid cohesion(GO:0007062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.6 4.7 GO:0098831 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569)
1.2 13.6 GO:0005955 calcineurin complex(GO:0005955)
1.1 5.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.1 8.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.4 2.6 GO:1990635 proximal dendrite(GO:1990635)
0.3 1.8 GO:1990584 cardiac Troponin complex(GO:1990584)
0.3 3.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 12.5 GO:0030673 axolemma(GO:0030673)
0.2 2.4 GO:0045180 basal cortex(GO:0045180)
0.2 3.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 6.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 4.3 GO:0000242 pericentriolar material(GO:0000242)
0.2 1.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 4.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.3 GO:0000813 ESCRT I complex(GO:0000813)
0.1 5.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 12.7 GO:0005882 intermediate filament(GO:0005882)
0.1 1.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.0 GO:0030897 HOPS complex(GO:0030897)
0.1 0.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 2.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 5.0 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 3.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.4 GO:0032982 myosin filament(GO:0032982)
0.0 1.4 GO:0034706 sodium channel complex(GO:0034706)
0.0 2.4 GO:0031904 endosome lumen(GO:0031904)
0.0 3.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 5.3 GO:0016605 PML body(GO:0016605)
0.0 2.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.2 GO:0055037 recycling endosome(GO:0055037)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.9 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 22.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
2.8 11.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.7 13.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.7 5.0 GO:0033746 histone demethylase activity (H3-R2 specific)(GO:0033746) histone demethylase activity (H4-R3 specific)(GO:0033749)
1.4 8.3 GO:0070728 leucine binding(GO:0070728)
1.2 3.7 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.9 12.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 2.6 GO:0034618 arginine binding(GO:0034618)
0.7 8.8 GO:0046870 cadmium ion binding(GO:0046870)
0.7 4.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 2.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.5 3.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 2.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.4 4.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 4.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 1.7 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 1.8 GO:0030172 troponin C binding(GO:0030172)
0.3 4.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 1.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.2 1.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 5.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 6.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.3 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 5.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 1.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 2.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.8 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 2.6 GO:0070402 NADPH binding(GO:0070402)
0.1 0.7 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 3.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 2.4 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 3.1 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.8 GO:0031489 myosin V binding(GO:0031489)
0.1 1.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 1.9 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 11.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.3 GO:0043236 laminin binding(GO:0043236)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 1.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 3.1 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 3.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 3.7 GO:0008017 microtubule binding(GO:0008017)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.3 GO:0003714 transcription corepressor activity(GO:0003714)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 5.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 2.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 1.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 3.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID ALK2 PATHWAY ALK2 signaling events
0.0 3.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.9 PID TNF PATHWAY TNF receptor signaling pathway
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 4.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.3 22.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 4.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 5.5 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.2 5.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 12.5 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 12.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 3.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.9 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 3.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 0.7 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 6.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 4.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 5.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides