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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TFAP2E

Z-value: 2.60

Motif logo

Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
ENSG00000116819.9 TFAP2E

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr11_+_82901698 11.12 ENST00000524921.5
ENST00000528759.5
ENST00000525361.5
ENST00000532764.5
ENST00000532589.5
ENST00000533655.6
ENST00000525388.5
DNA damage induced apoptosis suppressor
chr17_-_44915486 10.09 ENST00000638281.1
ENST00000588316.1
ENST00000588735.3
ENST00000639277.1
ENST00000253408.11
ENST00000435360.8
ENST00000586793.6
ENST00000588037.1
ENST00000592320.6
glial fibrillary acidic protein
chr16_+_56589521 8.83 ENST00000200691.5
ENST00000570176.1
metallothionein 3
chr1_-_11805977 8.05 ENST00000376486.3
methylenetetrahydrofolate reductase
chr1_-_11805924 7.57 ENST00000418034.1
methylenetetrahydrofolate reductase
chr12_+_75391078 7.04 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1 like 2
chr1_-_11805949 7.00 ENST00000376590.9
methylenetetrahydrofolate reductase
chr15_+_23565705 6.19 ENST00000568252.1
ENST00000649065.1
makorin ring finger protein 3
chr6_+_42564060 6.06 ENST00000372903.6
ubiquitin protein ligase E3 component n-recognin 2
chr7_-_45088888 5.73 ENST00000490531.3
NAC alpha domain containing
chr6_-_29633171 5.55 ENST00000377034.9
gamma-aminobutyric acid type B receptor subunit 1
chr6_-_29633056 5.51 ENST00000377016.8
gamma-aminobutyric acid type B receptor subunit 1
chr7_+_73433761 5.07 ENST00000344575.5
frizzled class receptor 9
chr17_-_76726753 4.98 ENST00000617192.4
jumonji domain containing 6, arginine demethylase and lysine hydroxylase
chr1_+_8945858 4.91 ENST00000549778.5
ENST00000377443.7
ENST00000480186.7
ENST00000377436.6
ENST00000377442.3
carbonic anhydrase 6
chr14_+_24368020 4.82 ENST00000554050.5
ENST00000554903.1
ENST00000250373.9
ENST00000554779.1
ENST00000553708.5
nuclear factor of activated T cells 4
chr19_+_4969105 4.79 ENST00000611640.4
ENST00000159111.9
ENST00000588337.5
ENST00000381759.8
lysine demethylase 4B
chr3_+_49554436 4.65 ENST00000296452.5
bassoon presynaptic cytomatrix protein
chr3_+_4493442 4.65 ENST00000456211.8
ENST00000443694.5
ENST00000648266.1
inositol 1,4,5-trisphosphate receptor type 1
chrX_+_153724847 4.62 ENST00000218104.6
ATP binding cassette subfamily D member 1
chr3_+_4493340 4.51 ENST00000357086.10
ENST00000354582.12
ENST00000649015.2
ENST00000467056.6
inositol 1,4,5-trisphosphate receptor type 1
chr17_+_3723889 4.50 ENST00000325418.5
histone H3 associated protein kinase
chr3_+_4493471 4.45 ENST00000544951.6
ENST00000650294.1
inositol 1,4,5-trisphosphate receptor type 1
chr3_-_48088800 3.79 ENST00000423088.5
microtubule associated protein 4
chr4_-_81471855 3.79 ENST00000436139.6
ENST00000613784.1
RasGEF domain family member 1B
chr17_-_38799442 3.71 ENST00000619039.5
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
chr19_-_45886120 3.39 ENST00000302165.5
interferon regulatory factor 2 binding protein 1
chr10_+_98134642 3.32 ENST00000298999.8
R3H domain and coiled-coil containing 1 like
chr18_-_76495191 3.29 ENST00000443185.7
zinc finger protein 516
chr2_+_218859794 3.26 ENST00000233948.4
Wnt family member 6
chr10_+_98134622 3.21 ENST00000370584.7
R3H domain and coiled-coil containing 1 like
chr2_+_73202570 3.20 ENST00000398468.4
notochord homeobox
chr22_+_39994926 3.14 ENST00000333407.11
family with sequence similarity 83 member F
chr15_-_52528870 3.13 ENST00000399233.7
ENST00000356338.10
myosin VA
chr20_+_24469623 3.13 ENST00000376862.4
synapse differentiation inducing 1
chr7_+_29194757 3.12 ENST00000222792.11
chimerin 2
chr7_-_140924699 3.10 ENST00000288602.11
ENST00000469930.2
ENST00000496384.7
B-Raf proto-oncogene, serine/threonine kinase
chr15_-_65211463 3.09 ENST00000261883.6
cartilage intermediate layer protein
chr11_-_47848539 3.04 ENST00000526870.1
nucleoporin 160
chr11_-_35419213 3.02 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
solute carrier family 1 member 2
chr7_+_35800932 3.01 ENST00000635172.1
ENST00000399034.7
ENST00000350320.10
ENST00000435235.6
ENST00000672279.1
ENST00000634600.1
ENST00000635047.1
septin 7
chr12_+_53050179 2.96 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
tensin 2
chr11_-_35419542 2.94 ENST00000643305.1
ENST00000644351.1
ENST00000278379.9
ENST00000644779.1
solute carrier family 1 member 2
chr8_-_126557691 2.81 ENST00000652209.1
LRAT domain containing 2
chr8_+_17922974 2.74 ENST00000517730.5
ENST00000518537.5
ENST00000523055.5
ENST00000519253.5
pericentriolar material 1
chr8_+_25184668 2.72 ENST00000276440.12
ENST00000410074.5
dedicator of cytokinesis 5
chr13_+_19958760 2.69 ENST00000382871.3
zinc finger MYM-type containing 2
chr13_+_19958708 2.65 ENST00000382874.6
ENST00000610343.5
zinc finger MYM-type containing 2
chr1_+_17308194 2.64 ENST00000375453.5
ENST00000375448.4
peptidyl arginine deiminase 4
chr3_+_156142962 2.60 ENST00000471742.5
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr4_-_2262082 2.58 ENST00000337190.7
MAX dimerization protein 4
chr2_+_38666059 2.58 ENST00000272252.10
ENST00000410063.5
galactose mutarotase
chr17_+_30831944 2.57 ENST00000321990.5
ATPase family AAA domain containing 5
chr11_-_35419462 2.50 ENST00000643522.1
solute carrier family 1 member 2
chr6_+_31586859 2.45 ENST00000433492.5
leukocyte specific transcript 1
chr7_-_140924900 2.43 ENST00000646891.1
ENST00000644969.2
B-Raf proto-oncogene, serine/threonine kinase
chr9_+_4985227 2.41 ENST00000381652.4
Janus kinase 2
chr13_-_26760741 2.39 ENST00000405846.5
G protein-coupled receptor 12
chr11_-_35419098 2.39 ENST00000606205.6
ENST00000645303.1
solute carrier family 1 member 2
chr19_-_43465596 2.30 ENST00000244333.4
LY6/PLAUR domain containing 3
chr6_+_42563981 2.23 ENST00000372899.6
ENST00000372901.2
ubiquitin protein ligase E3 component n-recognin 2
chr4_-_152679984 2.18 ENST00000304385.8
ENST00000504064.1
transmembrane protein 154
chr9_-_34662654 2.12 ENST00000259631.5
C-C motif chemokine ligand 27
chr13_-_75482114 2.12 ENST00000377625.6
ENST00000431480.6
TBC1 domain family member 4
chr6_+_7107597 2.00 ENST00000379933.7
ENST00000491191.5
ENST00000471433.5
ras responsive element binding protein 1
chr10_+_91220603 2.00 ENST00000336126.6
polycomb group ring finger 5
chr13_-_75482151 1.97 ENST00000377636.8
TBC1 domain family member 4
chr6_+_13272709 1.96 ENST00000379335.8
phosphatase and actin regulator 1
chr12_-_14567714 1.94 ENST00000240617.10
phospholipase B domain containing 1
chr17_-_41612757 1.93 ENST00000301653.9
ENST00000593067.1
keratin 16
chr19_+_8390316 1.84 ENST00000328024.11
ENST00000601897.1
ENST00000594216.1
RAB11B, member RAS oncogene family
chr19_-_38773432 1.83 ENST00000599035.1
ENST00000378626.5
galectin 7
chr1_-_201377652 1.80 ENST00000455702.6
ENST00000367320.6
ENST00000421663.6
ENST00000412633.3
ENST00000367318.10
ENST00000422165.6
ENST00000656932.1
ENST00000438742.6
ENST00000367322.6
ENST00000458432.6
ENST00000509001.5
ENST00000660295.1
troponin T2, cardiac type
chr7_-_100468063 1.78 ENST00000423266.5
ENST00000456330.1
TSC22 domain family member 4
chr9_-_21077938 1.78 ENST00000380232.4
interferon beta 1
chr14_+_103385374 1.77 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
microtubule affinity regulating kinase 3
chr1_-_114511160 1.71 ENST00000369543.6
ENST00000358465.7
tripartite motif containing 33
chr19_+_45001430 1.68 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB proto-oncogene, NF-kB subunit
chr7_-_23014099 1.65 ENST00000432176.7
ENST00000440481.6
family with sequence similarity 126 member A
chr3_-_136752361 1.64 ENST00000480733.1
ENST00000629124.2
ENST00000383202.7
ENST00000236698.9
ENST00000434713.6
stromal antigen 1
chr6_+_31586835 1.60 ENST00000211921.11
leukocyte specific transcript 1
chr8_+_17922837 1.60 ENST00000325083.12
pericentriolar material 1
chr5_+_134648772 1.59 ENST00000398844.7
ENST00000322887.8
SEC24 homolog A, COPII coat complex component
chr11_-_35420017 1.58 ENST00000643000.1
ENST00000646099.1
ENST00000647372.1
ENST00000642578.1
solute carrier family 1 member 2
chr19_+_35704540 1.58 ENST00000392197.7
ENST00000426659.6
zinc finger and BTB domain containing 32
chr14_+_103385450 1.51 ENST00000416682.6
microtubule affinity regulating kinase 3
chr19_+_50432885 1.42 ENST00000357701.6
myosin binding protein C2
chr19_+_49157780 1.41 ENST00000599628.5
ENST00000252826.10
ENST00000427978.6
transient receptor potential cation channel subfamily M member 4
chr10_-_110919146 1.40 ENST00000652396.1
ENST00000423273.5
ENST00000436562.1
ENST00000651952.1
ENST00000448814.7
ENST00000652400.1
ENST00000447005.5
ENST00000454061.5
BBSome interacting protein 1
chr2_+_6917404 1.38 ENST00000320892.11
ring finger protein 144A
chr11_-_66289007 1.34 ENST00000431556.6
ENST00000528575.1
Yip1 interacting factor homolog A, membrane trafficking protein
chr9_+_126326809 1.33 ENST00000361171.8
ENST00000489637.3
multivesicular body subunit 12B
chr5_+_177133005 1.27 ENST00000510954.5
ENST00000354179.8
nuclear receptor binding SET domain protein 1
chr10_-_96513911 1.26 ENST00000357947.4
tolloid like 2
chr11_+_118607579 1.26 ENST00000530708.4
pleckstrin homology like domain family B member 1
chr11_+_116829898 1.25 ENST00000227667.8
ENST00000375345.3
apolipoprotein C3
chr4_+_153466324 1.24 ENST00000409663.7
ENST00000409959.8
transmembrane 131 like
chr14_+_20745880 1.20 ENST00000326842.3
epididymal protein 3A
chr7_+_32495447 1.20 ENST00000318709.9
ENST00000409301.5
ENST00000640103.1
AVL9 cell migration associated
chrX_+_129738942 1.19 ENST00000371106.4
X-prolyl aminopeptidase 2
chr3_+_52779916 1.18 ENST00000537050.5
inter-alpha-trypsin inhibitor heavy chain 1
chr3_-_48088824 1.17 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
microtubule associated protein 4
chr20_+_19212624 1.15 ENST00000328041.11
solute carrier family 24 member 3
chr17_-_35089212 1.14 ENST00000584655.5
ENST00000447669.6
ENST00000315249.11
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr5_-_180072086 1.11 ENST00000261947.4
ring finger protein 130
chr11_+_118607598 1.10 ENST00000600882.6
ENST00000356063.9
pleckstrin homology like domain family B member 1
chr2_-_177264686 1.05 ENST00000397062.8
ENST00000430047.1
nuclear factor, erythroid 2 like 2
chr3_+_50155305 1.04 ENST00000002829.8
ENST00000426511.5
semaphorin 3F
chr20_+_2840694 1.03 ENST00000380469.7
ENST00000380445.8
ENST00000453689.5
ENST00000417508.1
VPS16 core subunit of CORVET and HOPS complexes
chr1_+_3069195 0.96 ENST00000378391.6
ENST00000270722.10
ENST00000514189.5
PR/SET domain 16
chr6_+_31586680 0.91 ENST00000339530.8
leukocyte specific transcript 1
chr5_-_151924846 0.91 ENST00000274576.9
glycine receptor alpha 1
chr2_-_240892007 0.90 ENST00000402775.6
ENST00000307486.12
mab-21 like 4
chr10_-_77637902 0.86 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
potassium calcium-activated channel subfamily M alpha 1
chr5_-_180071708 0.83 ENST00000522208.6
ENST00000521389.6
ring finger protein 130
chr5_-_151924824 0.80 ENST00000455880.2
glycine receptor alpha 1
chr9_+_133636355 0.79 ENST00000393056.8
dopamine beta-hydroxylase
chr19_+_3572777 0.77 ENST00000416526.5
high mobility group 20B
chrX_-_49079702 0.76 ENST00000636049.1
ENST00000474053.6
ENST00000635003.1
WD repeat domain 45
chr11_+_3855629 0.75 ENST00000526596.2
ENST00000300737.8
ENST00000616714.4
stromal interaction molecule 1
chr10_-_77638369 0.74 ENST00000372443.6
potassium calcium-activated channel subfamily M alpha 1
chr14_+_103385506 0.72 ENST00000303622.13
microtubule affinity regulating kinase 3
chr11_-_47848313 0.72 ENST00000530326.5
ENST00000528071.5
nucleoporin 160
chr11_-_71252492 0.69 ENST00000601538.6
SH3 and multiple ankyrin repeat domains 2
chr9_+_35605234 0.61 ENST00000336395.6
testis associated actin remodelling kinase 1
chr2_+_74514442 0.59 ENST00000233638.8
T cell leukemia homeobox 2
chr11_-_82901654 0.56 ENST00000534631.5
ENST00000531801.6
ENST00000680524.1
ENST00000531128.5
ENST00000680566.1
prolylcarboxypeptidase
chr11_-_82901623 0.52 ENST00000681637.1
ENST00000679387.1
prolylcarboxypeptidase
chr16_+_69566041 0.51 ENST00000567239.5
nuclear factor of activated T cells 5
chr11_-_82901594 0.45 ENST00000679623.1
prolylcarboxypeptidase
chr8_+_124450806 0.45 ENST00000328599.4
tRNA methyltransferase 12 homolog
chr1_-_85048437 0.44 ENST00000341115.8
ENST00000370587.5
ENST00000370589.7
mucolipin TRP cation channel 3
chr2_-_23927107 0.39 ENST00000238789.10
ATPase family AAA domain containing 2B
chr14_-_25049889 0.38 ENST00000419632.6
ENST00000396700.5
syntaxin binding protein 6
chr4_-_100517991 0.37 ENST00000511970.5
ENST00000502569.1
ENST00000305864.7
ENST00000296420.9
endomucin
chr14_-_25050111 0.30 ENST00000323944.9
syntaxin binding protein 6
chr3_+_53161120 0.28 ENST00000394729.6
ENST00000330452.8
ENST00000652449.1
protein kinase C delta
chr9_+_35605277 0.28 ENST00000620767.4
testis associated actin remodelling kinase 1
chrX_+_116436599 0.22 ENST00000598581.3
solute carrier family 6 member 14
chr17_+_76074772 0.21 ENST00000329003.4
galanin receptor 2
chr15_+_84817346 0.16 ENST00000258888.6
alpha kinase 3
chr10_-_124092445 0.14 ENST00000346248.7
carbohydrate sulfotransferase 15
chr11_-_47848467 0.09 ENST00000378460.6
nucleoporin 160
chr19_+_43576800 0.08 ENST00000612042.4
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr1_-_113812448 0.06 ENST00000612242.4
ENST00000261441.9
round spermatid basic protein 1
chr17_+_39668447 0.05 ENST00000269582.3
ENST00000581428.1
phenylethanolamine N-methyltransferase
chr4_+_41990496 0.05 ENST00000264451.12
solute carrier family 30 member 9
chr11_-_35419899 0.04 ENST00000646847.1
ENST00000449068.2
ENST00000643401.1
ENST00000645966.1
ENST00000647104.1
solute carrier family 1 member 2
chr20_+_6767678 0.02 ENST00000378827.5
bone morphogenetic protein 2
chr2_-_37324826 0.01 ENST00000234179.8
protein kinase D3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 22.6 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
2.9 8.8 GO:2000296 lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
1.7 13.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.7 5.1 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
1.7 5.0 GO:0070079 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine(GO:0018395) histone arginine demethylation(GO:0070077) histone H3-R2 demethylation(GO:0070078) histone H4-R3 demethylation(GO:0070079)
1.7 8.3 GO:0071233 cellular response to leucine(GO:0071233)
1.6 4.7 GO:0099526 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
1.2 4.8 GO:2000297 negative regulation of synapse maturation(GO:2000297)
1.2 4.6 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.9 5.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.9 2.6 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.8 12.5 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.8 5.0 GO:0051012 microtubule sliding(GO:0051012)
0.8 2.4 GO:0060398 mineralocorticoid receptor signaling pathway(GO:0031959) regulation of growth hormone receptor signaling pathway(GO:0060398) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.7 4.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.7 2.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.6 3.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.6 4.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.5 2.7 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.5 3.3 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.5 10.1 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.5 1.4 GO:1903781 positive regulation of cardiac conduction(GO:1903781)
0.5 1.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.4 1.3 GO:0019075 virus maturation(GO:0019075)
0.4 4.0 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.4 1.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.4 3.7 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.3 4.8 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.3 1.2 GO:2000909 regulation of high-density lipoprotein particle clearance(GO:0010982) regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.3 3.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 1.1 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.3 1.3 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.2 1.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 11.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 1.8 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 2.4 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.2 1.8 GO:0045054 constitutive secretory pathway(GO:0045054)
0.2 1.8 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.2 1.5 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.2 1.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 4.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.7 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.2 1.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.2 3.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.2 2.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 1.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 2.6 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 1.0 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 1.2 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 1.6 GO:0045794 response to carbon monoxide(GO:0034465) negative regulation of cell volume(GO:0045794)
0.1 3.2 GO:0044458 motile cilium assembly(GO:0044458)
0.1 1.9 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 0.8 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.1 1.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 3.0 GO:0014850 response to muscle activity(GO:0014850)
0.1 0.3 GO:2000754 regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755)
0.1 1.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.7 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 1.4 GO:0051546 keratinocyte migration(GO:0051546)
0.1 1.2 GO:0007320 insemination(GO:0007320)
0.1 2.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 3.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.8 GO:0044804 nucleophagy(GO:0044804)
0.0 3.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 1.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.6 GO:0048484 enteric nervous system development(GO:0048484)
0.0 10.5 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.5 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 1.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.7 GO:0060292 long term synaptic depression(GO:0060292)
0.0 1.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 1.7 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015)
0.0 6.2 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 0.4 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.0 1.6 GO:0007062 sister chromatid cohesion(GO:0007062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.6 4.7 GO:0098831 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569)
1.2 13.6 GO:0005955 calcineurin complex(GO:0005955)
1.1 5.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.1 8.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.4 2.6 GO:1990635 proximal dendrite(GO:1990635)
0.3 1.8 GO:1990584 cardiac Troponin complex(GO:1990584)
0.3 3.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 12.5 GO:0030673 axolemma(GO:0030673)
0.2 2.4 GO:0045180 basal cortex(GO:0045180)
0.2 3.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 6.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 4.3 GO:0000242 pericentriolar material(GO:0000242)
0.2 1.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 4.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.3 GO:0000813 ESCRT I complex(GO:0000813)
0.1 5.1 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 12.7 GO:0005882 intermediate filament(GO:0005882)
0.1 1.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.0 GO:0030897 HOPS complex(GO:0030897)
0.1 0.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 2.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 5.0 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 3.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.4 GO:0032982 myosin filament(GO:0032982)
0.0 1.4 GO:0034706 sodium channel complex(GO:0034706)
0.0 2.4 GO:0031904 endosome lumen(GO:0031904)
0.0 3.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 5.3 GO:0016605 PML body(GO:0016605)
0.0 2.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.2 GO:0055037 recycling endosome(GO:0055037)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.9 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 22.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
2.8 11.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.7 13.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.7 5.0 GO:0033746 histone demethylase activity (H3-R2 specific)(GO:0033746) histone demethylase activity (H4-R3 specific)(GO:0033749)
1.4 8.3 GO:0070728 leucine binding(GO:0070728)
1.2 3.7 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.9 12.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 2.6 GO:0034618 arginine binding(GO:0034618)
0.7 8.8 GO:0046870 cadmium ion binding(GO:0046870)
0.7 4.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 2.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.5 3.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 2.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.4 4.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 4.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 1.7 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 1.8 GO:0030172 troponin C binding(GO:0030172)
0.3 4.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 1.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.2 1.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 5.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 6.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.3 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 5.5 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 1.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 2.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.8 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 2.6 GO:0070402 NADPH binding(GO:0070402)
0.1 0.7 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 3.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 2.4 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 3.1 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.8 GO:0031489 myosin V binding(GO:0031489)
0.1 1.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 1.9 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 11.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.3 GO:0043236 laminin binding(GO:0043236)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 1.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 3.1 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 3.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 3.7 GO:0008017 microtubule binding(GO:0008017)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.3 GO:0003714 transcription corepressor activity(GO:0003714)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 5.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 2.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 1.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 3.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID ALK2 PATHWAY ALK2 signaling events
0.0 3.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.9 PID TNF PATHWAY TNF receptor signaling pathway
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 4.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.3 22.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 4.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 5.5 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.2 5.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 12.5 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 12.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 3.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.9 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 3.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 0.7 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 6.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 4.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 5.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides