ISMARA results: THRA

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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for THRA_RXRB

Z-value: 0.40

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Transcription factors associated with THRA_RXRB

Gene Symbol	Gene ID	Gene Info
THRA Ensembl NCBI GeneCards UniProt	ENSG00000126351.13	THRA
RXRB Ensembl NCBI GeneCards UniProt	ENSG00000204231.11	RXRB

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
THRA	hg38_v1_chr17_+_40062810_40062901	-0.40	1.3e-09	Click!
RXRB	hg38_v1_chr6_-_33200614_33200680	-0.01	9.1e-01	Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

View svg image
View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr22_+_22922594 Show fit	77.10	ENST00000390331.3	IGLC7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 7
chr14_-_105708627 Show fit	30.93	ENST00000641837.1 ENST00000390547.3	IGHA1 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy constant alpha 1
chr22_+_22734577 Show fit	27.85	ENST00000390310.3	IGLV2-18 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-18
chr22_+_22792485 Show fit	22.54	ENST00000390314.2	IGLV2-11 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-11
chr22_+_22758698 Show fit	21.94	ENST00000390312.2	IGLV2-14 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-14
chr22_+_22822658 Show fit	21.50	ENST00000620395.2	IGLV2-8 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-8
chr19_-_39335999 Show fit	20.77	ENST00000602185.5 ENST00000598034.5 ENST00000601387.5 ENST00000595636.1 ENST00000253054.12 ENST00000594700.5 ENST00000597595.6	GMFG Ensembl NCBI GeneCards UniProt Show fit	glia maturation factor gamma
chr22_+_22900976 Show fit	20.45	ENST00000390323.2	IGLC2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 2
chr14_-_105588322 Show fit	19.69	ENST00000497872.4 ENST00000390539.2	IGHA2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy constant alpha 2 (A2m marker)
chr22_+_22431949 Show fit	18.21	ENST00000390301.3	IGLV1-36 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 1-36
chr16_+_85908988 Show fit	16.49	ENST00000566369.1	IRF8 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 8
chr1_-_159925496 Show fit	15.72	ENST00000368097.9	TAGLN2 Ensembl NCBI GeneCards UniProt Show fit	transgelin 2
chr6_+_139135063 Show fit	10.72	ENST00000367658.3	HECA Ensembl NCBI GeneCards UniProt Show fit	hdc homolog, cell cycle regulator
chr22_+_22327298 Show fit	10.62	ENST00000390291.2	IGLV1-50 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 1-50 (non-functional)
chr22_+_22409755 Show fit	8.84	ENST00000390299.2	IGLV1-40 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 1-40
chr2_-_229921963 Show fit	8.32	ENST00000343290.5 ENST00000389044.8 ENST00000675453.1 ENST00000675903.1 ENST00000283943.9	TRIP12 Ensembl NCBI GeneCards UniProt Show fit	thyroid hormone receptor interactor 12
chr1_-_149927756 Show fit	8.03	ENST00000271628.9	SF3B4 Ensembl NCBI GeneCards UniProt Show fit	splicing factor 3b subunit 4
chr22_+_22594528 Show fit	7.95	ENST00000390303.3	IGLV3-32 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 3-32 (non-functional)
chr19_+_49335396 Show fit	7.88	ENST00000598095.5 ENST00000426897.6 ENST00000323906.9 ENST00000535669.6 ENST00000597602.1 ENST00000595660.1	CD37 Ensembl NCBI GeneCards UniProt Show fit	CD37 molecule
chr5_-_150449731 Show fit	7.20	ENST00000407193.7	RPS14 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S14
chr20_+_44715360 Show fit	7.05	ENST00000190983.5	CCN5 Ensembl NCBI GeneCards UniProt Show fit	cellular communication network factor 5
chr13_-_41061373 Show fit	6.61	ENST00000405737.2	ELF1 Ensembl NCBI GeneCards UniProt Show fit	E74 like ETS transcription factor 1
chr14_+_22494810 Show fit	6.58	ENST00000390493.1	TRAJ44 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor alpha joining 44
chr6_-_33314055 Show fit	6.51	ENST00000434618.7	TAPBP Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein
chr2_-_229921903 Show fit	6.14	ENST00000389045.7 ENST00000409677.5	TRIP12 Ensembl NCBI GeneCards UniProt Show fit	thyroid hormone receptor interactor 12
chr22_+_22357739 Show fit	6.14	ENST00000390294.2	IGLV1-47 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 1-47
chr14_-_58427114 Show fit	5.90	ENST00000556007.6	TIMM9 Ensembl NCBI GeneCards UniProt Show fit	translocase of inner mitochondrial membrane 9
chr5_-_150449676 Show fit	5.87	ENST00000312037.6	RPS14 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S14
chr11_-_58575846 Show fit	5.80	ENST00000395074.7	LPXN Ensembl NCBI GeneCards UniProt Show fit	leupaxin
chr14_-_23567734 Show fit	5.74	ENST00000556843.1 ENST00000397120.8 ENST00000557189.5	AP1G2 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 1 subunit gamma 2
chr13_-_46182136 Show fit	5.55	ENST00000323076.7	LCP1 Ensembl NCBI GeneCards UniProt Show fit	lymphocyte cytosolic protein 1
chrX_-_153724343 Show fit	5.54	ENST00000442093.5 ENST00000345046.12 ENST00000645377.1 ENST00000672675.1 ENST00000647529.1 ENST00000429550.5	BCAP31 Ensembl NCBI GeneCards UniProt Show fit	B cell receptor associated protein 31
chr19_-_10339610 Show fit	5.48	ENST00000589261.5 ENST00000160262.10 ENST00000590569.1 ENST00000589580.1 ENST00000589249.1	ICAM3 Ensembl NCBI GeneCards UniProt Show fit	intercellular adhesion molecule 3
chr5_-_150449696 Show fit	4.95	ENST00000401695.8	RPS14 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S14
chr5_+_40679907 Show fit	4.80	ENST00000302472.4	PTGER4 Ensembl NCBI GeneCards UniProt Show fit	prostaglandin E receptor 4
chr1_-_175192911 Show fit	4.79	ENST00000444639.5	KIAA0040 Ensembl NCBI GeneCards UniProt Show fit	KIAA0040
chr15_+_86079863 Show fit	4.73	ENST00000614907.3 ENST00000441037.7	AGBL1 Ensembl NCBI GeneCards UniProt Show fit	ATP/GTP binding protein like 1
chr13_+_75549734 Show fit	4.56	ENST00000563635.5 ENST00000377595.8	ENSG00000261553.5 Ensembl NCBI GeneCards UniProt Show fit UCHL3 Ensembl NCBI GeneCards UniProt Show fit	novel transcript ubiquitin C-terminal hydrolase L3
chr1_+_40738834 Show fit	4.55	ENST00000525290.5 ENST00000530965.5 ENST00000416859.6 ENST00000308733.9	NFYC Ensembl NCBI GeneCards UniProt Show fit	nuclear transcription factor Y subunit gamma
chr13_+_75549477 Show fit	4.38	ENST00000618773.4	UCHL3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin C-terminal hydrolase L3
chr5_-_181239571 Show fit	4.07	ENST00000509535.5	RACK1 Ensembl NCBI GeneCards UniProt Show fit	receptor for activated C kinase 1
chr14_-_58427158 Show fit	4.01	ENST00000555097.1 ENST00000556367.6 ENST00000555404.5	TIMM9 Ensembl NCBI GeneCards UniProt Show fit	translocase of inner mitochondrial membrane 9
chr2_+_130182224 Show fit	3.98	ENST00000651060.1 ENST00000409255.1 ENST00000281871.11 ENST00000455239.1	MZT2B Ensembl NCBI GeneCards UniProt Show fit	mitotic spindle organizing protein 2B
chr1_-_159924529 Show fit	3.98	ENST00000320307.8	TAGLN2 Ensembl NCBI GeneCards UniProt Show fit	transgelin 2
chr3_-_128153782 Show fit	3.80	ENST00000464873.5	RUVBL1 Ensembl NCBI GeneCards UniProt Show fit	RuvB like AAA ATPase 1
chr2_-_175181663 Show fit	3.80	ENST00000392541.3 ENST00000284727.9 ENST00000409194.5	ATP5MC3 Ensembl NCBI GeneCards UniProt Show fit	ATP synthase membrane subunit c locus 3
chr16_+_1309714 Show fit	3.66	ENST00000566587.5	UBE2I Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 I
chr6_+_21593742 Show fit	3.49	ENST00000244745.4	SOX4 Ensembl NCBI GeneCards UniProt Show fit	SRY-box transcription factor 4
chr12_-_102120065 Show fit	3.49	ENST00000552283.6 ENST00000551744.2	NUP37 Ensembl NCBI GeneCards UniProt Show fit	nucleoporin 37
chr17_+_8288637 Show fit	3.45	ENST00000407006.8 ENST00000226105.11 ENST00000580434.5 ENST00000439238.3	RANGRF Ensembl NCBI GeneCards UniProt Show fit	RAN guanine nucleotide release factor
chr14_-_103562637 Show fit	3.35	ENST00000299204.6	BAG5 Ensembl NCBI GeneCards UniProt Show fit	BAG cochaperone 5
chr14_-_103562257 Show fit	3.20	ENST00000337322.4 ENST00000445922.2	BAG5 Ensembl NCBI GeneCards UniProt Show fit	BAG cochaperone 5
chr15_+_43792305 Show fit	3.18	ENST00000249786.9 ENST00000409960.6 ENST00000409646.5 ENST00000339624.9 ENST00000409291.5 ENST00000402131.5 ENST00000403425.5 ENST00000430901.1	SERF2 Ensembl NCBI GeneCards UniProt Show fit	small EDRK-rich factor 2
chrX_-_130165664 Show fit	3.14	ENST00000535724.6 ENST00000346424.6 ENST00000676436.1	AIFM1 Ensembl NCBI GeneCards UniProt Show fit	apoptosis inducing factor mitochondria associated 1
chrX_-_130165699 Show fit	3.14	ENST00000676328.1 ENST00000675857.1 ENST00000675427.1 ENST00000675092.1	AIFM1 Ensembl NCBI GeneCards UniProt Show fit	apoptosis inducing factor mitochondria associated 1
chr22_-_21227637 Show fit	3.12	ENST00000401924.5	GGT2 Ensembl NCBI GeneCards UniProt Show fit	gamma-glutamyltransferase 2
chr2_+_55232359 Show fit	3.06	ENST00000449323.5	RPS27A Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S27a
chr17_-_42979993 Show fit	2.97	ENST00000409103.5 ENST00000360221.8 ENST00000454303.1 ENST00000591916.7 ENST00000451885.3	PTGES3L-AARSD1 Ensembl NCBI GeneCards UniProt Show fit PTGES3L Ensembl NCBI GeneCards UniProt Show fit	PTGES3L-AARSD1 readthrough prostaglandin E synthase 3 like
chr20_+_3796288 Show fit	2.92	ENST00000439880.6 ENST00000245960.10	CDC25B Ensembl NCBI GeneCards UniProt Show fit	cell division cycle 25B
chr7_+_5045821 Show fit	2.83	ENST00000353796.7 ENST00000396912.2 ENST00000396904.2	RBAK Ensembl NCBI GeneCards UniProt Show fit RBAK-RBAKDN Ensembl NCBI GeneCards UniProt Show fit	RB associated KRAB zinc finger RBAK-RBAKDN readthrough
chr11_+_313391 Show fit	2.81	ENST00000680802.1 ENST00000528780.5 ENST00000681761.1 ENST00000681821.1 ENST00000328221.5	IFITM1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced transmembrane protein 1
chr17_+_28744034 Show fit	2.79	ENST00000444415.7 ENST00000262396.10	TRAF4 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor associated factor 4
chr12_+_55818033 Show fit	2.74	ENST00000552672.5 ENST00000243045.10 ENST00000550836.1	ORMDL2 Ensembl NCBI GeneCards UniProt Show fit	ORMDL sphingolipid biosynthesis regulator 2
chr1_+_54641806 Show fit	2.68	ENST00000409996.5	MROH7 Ensembl NCBI GeneCards UniProt Show fit	maestro heat like repeat family member 7
chr16_+_3024000 Show fit	2.68	ENST00000326266.13 ENST00000574549.5 ENST00000575576.5 ENST00000253952.9	THOC6 Ensembl NCBI GeneCards UniProt Show fit	THO complex 6
chr1_+_54641754 Show fit	2.64	ENST00000339553.9 ENST00000421030.7	MROH7 Ensembl NCBI GeneCards UniProt Show fit	maestro heat like repeat family member 7
chr13_-_94479671 Show fit	2.64	ENST00000377028.10 ENST00000446125.1	DCT Ensembl NCBI GeneCards UniProt Show fit	dopachrome tautomerase
chr2_-_182522556 Show fit	2.62	ENST00000435564.5	PDE1A Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 1A
chr8_+_102551583 Show fit	2.60	ENST00000285402.4	ODF1 Ensembl NCBI GeneCards UniProt Show fit	outer dense fiber of sperm tails 1
chr12_-_114406133 Show fit	2.59	ENST00000405440.7	TBX5 Ensembl NCBI GeneCards UniProt Show fit	T-box transcription factor 5
chr20_+_37179310 Show fit	2.57	ENST00000373632.8 ENST00000237530.11	RPN2 Ensembl NCBI GeneCards UniProt Show fit	ribophorin II
chr19_-_40690629 Show fit	2.56	ENST00000252891.8	NUMBL Ensembl NCBI GeneCards UniProt Show fit	NUMB like endocytic adaptor protein
chr8_+_144095054 Show fit	2.56	ENST00000318911.5	CYC1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome c1
chr3_+_12287962 Show fit	2.55	ENST00000643197.2 ENST00000644622.2	PPARG Ensembl NCBI GeneCards UniProt Show fit	peroxisome proliferator activated receptor gamma
chr22_-_28741783 Show fit	2.54	ENST00000439200.5 ENST00000405598.5 ENST00000398017.3 ENST00000649563.1 ENST00000650281.1 ENST00000425190.7 ENST00000404276.6 ENST00000650233.1 ENST00000348295.7 ENST00000382580.6	CHEK2 Ensembl NCBI GeneCards UniProt Show fit	checkpoint kinase 2
chr1_+_203305510 Show fit	2.52	ENST00000290551.5	BTG2 Ensembl NCBI GeneCards UniProt Show fit	BTG anti-proliferation factor 2
chr20_+_48921701 Show fit	2.50	ENST00000371917.5	ARFGEF2 Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor guanine nucleotide exchange factor 2
chr19_+_16076485 Show fit	2.49	ENST00000643579.2 ENST00000646575.1	TPM4 Ensembl NCBI GeneCards UniProt Show fit	tropomyosin 4
chr17_-_5486157 Show fit	2.43	ENST00000572834.5 ENST00000158771.9 ENST00000570848.5 ENST00000571971.1	DERL2 Ensembl NCBI GeneCards UniProt Show fit	derlin 2
chr20_+_37179109 Show fit	2.40	ENST00000373622.9	RPN2 Ensembl NCBI GeneCards UniProt Show fit	ribophorin II
chr8_-_130016395 Show fit	2.37	ENST00000523509.5	CYRIB Ensembl NCBI GeneCards UniProt Show fit	CYFIP related Rac1 interactor B
chr16_+_85613252 Show fit	2.35	ENST00000253458.12 ENST00000393243.5	GSE1 Ensembl NCBI GeneCards UniProt Show fit	Gse1 coiled-coil protein
chr1_-_175192769 Show fit	2.33	ENST00000423313.6	KIAA0040 Ensembl NCBI GeneCards UniProt Show fit	KIAA0040
chr1_+_155613221 Show fit	2.32	ENST00000462250.2	MSTO1 Ensembl NCBI GeneCards UniProt Show fit	misato mitochondrial distribution and morphology regulator 1
chr14_-_54902807 Show fit	2.32	ENST00000543643.6 ENST00000536224.2 ENST00000395514.5 ENST00000491895.7	GCH1 Ensembl NCBI GeneCards UniProt Show fit	GTP cyclohydrolase 1
chr3_+_113532508 Show fit	2.29	ENST00000264852.9	SIDT1 Ensembl NCBI GeneCards UniProt Show fit	SID1 transmembrane family member 1
chr3_+_12287899 Show fit	2.29	ENST00000643888.2	PPARG Ensembl NCBI GeneCards UniProt Show fit	peroxisome proliferator activated receptor gamma
chr9_+_113536497 Show fit	2.28	ENST00000462143.5	RGS3 Ensembl NCBI GeneCards UniProt Show fit	regulator of G protein signaling 3
chr17_+_28744002 Show fit	2.26	ENST00000618771.1 ENST00000262395.10 ENST00000422344.5	TRAF4 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor associated factor 4
chr15_-_34337462 Show fit	2.24	ENST00000676379.1	SLC12A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 6
chr11_-_5509929 Show fit	2.22	ENST00000311659.5 ENST00000445998.1	UBQLN3 Ensembl NCBI GeneCards UniProt Show fit	ubiquilin 3
chr7_+_100589573 Show fit	2.16	ENST00000468962.5 ENST00000427939.2	FBXO24 Ensembl NCBI GeneCards UniProt Show fit	F-box protein 24
chr16_+_1309621 Show fit	2.14	ENST00000397515.6 ENST00000397514.8 ENST00000567383.6 ENST00000403747.6	UBE2I Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 I
chr19_+_6739650 Show fit	2.14	ENST00000313285.12 ENST00000313244.14 ENST00000596758.5	TRIP10 Ensembl NCBI GeneCards UniProt Show fit	thyroid hormone receptor interactor 10
chr2_-_178451094 Show fit	2.11	ENST00000677981.1 ENST00000678845.1 ENST00000677689.1 ENST00000325748.9 ENST00000678775.1	PRKRA Ensembl NCBI GeneCards UniProt Show fit	protein activator of interferon induced protein kinase EIF2AK2
chr3_+_12287859 Show fit	2.09	ENST00000309576.11 ENST00000397015.7	PPARG Ensembl NCBI GeneCards UniProt Show fit	peroxisome proliferator activated receptor gamma
chr5_+_136058849 Show fit	2.06	ENST00000508076.5	TGFBI Ensembl NCBI GeneCards UniProt Show fit	transforming growth factor beta induced
chr10_+_73998104 Show fit	2.05	ENST00000372755.7 ENST00000211998.10	VCL Ensembl NCBI GeneCards UniProt Show fit	vinculin
chr22_+_22162155 Show fit	2.04	ENST00000390284.2	IGLV4-60 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 4-60
chr2_-_178450764 Show fit	2.03	ENST00000487082.5	PRKRA Ensembl NCBI GeneCards UniProt Show fit	protein activator of interferon induced protein kinase EIF2AK2
chr2_-_178450726 Show fit	1.95	ENST00000432031.6	PRKRA Ensembl NCBI GeneCards UniProt Show fit	protein activator of interferon induced protein kinase EIF2AK2
chr19_+_58387260 Show fit	1.95	ENST00000598098.5 ENST00000598495.5 ENST00000196551.8 ENST00000596046.1	RPS5 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S5
chr7_+_73830988 Show fit	1.92	ENST00000340958.4	CLDN4 Ensembl NCBI GeneCards UniProt Show fit	claudin 4
chr8_-_130016622 Show fit	1.89	ENST00000518283.5 ENST00000519110.5	CYRIB Ensembl NCBI GeneCards UniProt Show fit	CYFIP related Rac1 interactor B
chr2_-_182522703 Show fit	1.88	ENST00000410103.1	PDE1A Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 1A
chr2_+_44941695 Show fit	1.88	ENST00000260653.5	SIX3 Ensembl NCBI GeneCards UniProt Show fit	SIX homeobox 3
chr6_+_159727492 Show fit	1.87	ENST00000621533.5	WTAP Ensembl NCBI GeneCards UniProt Show fit	WT1 associated protein
chr22_+_22195753 Show fit	1.86	ENST00000390285.4	IGLV6-57 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 6-57
chr11_+_122838492 Show fit	1.86	ENST00000227348.9	CRTAM Ensembl NCBI GeneCards UniProt Show fit	cytotoxic and regulatory T cell molecule
chr3_-_195543308 Show fit	1.86	ENST00000618156.5	PPP1R2 Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1 regulatory inhibitor subunit 2
chr3_-_187291680 Show fit	1.84	ENST00000425937.1 ENST00000337774.10 ENST00000296280.11	MASP1 Ensembl NCBI GeneCards UniProt Show fit	mannan binding lectin serine peptidase 1
chr15_-_34337772 Show fit	1.83	ENST00000354181.8	SLC12A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 6
chr14_-_37595224 Show fit	1.80	ENST00000250448.5	FOXA1 Ensembl NCBI GeneCards UniProt Show fit	forkhead box A1
chr2_+_55232672 Show fit	1.79	ENST00000404735.1 ENST00000272317.11	RPS27A Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S27a
chr19_-_39738017 Show fit	1.76	ENST00000221804.5	CLC Ensembl NCBI GeneCards UniProt Show fit	Charcot-Leyden crystal galectin
chr10_+_102419189 Show fit	1.75	ENST00000432590.5	FBXL15 Ensembl NCBI GeneCards UniProt Show fit	F-box and leucine rich repeat protein 15
chr17_-_42980393 Show fit	1.73	ENST00000409446.8 ENST00000409399.6 ENST00000421990.7	PTGES3L Ensembl NCBI GeneCards UniProt Show fit PTGES3L-AARSD1 Ensembl NCBI GeneCards UniProt Show fit	prostaglandin E synthase 3 like PTGES3L-AARSD1 readthrough
chr9_+_136410650 Show fit	1.71	ENST00000371717.8 ENST00000399219.7	PMPCA Ensembl NCBI GeneCards UniProt Show fit	peptidase, mitochondrial processing subunit alpha
chr9_+_122371036 Show fit	1.70	ENST00000619306.5 ENST00000426608.6 ENST00000223423.8	PTGS1 Ensembl NCBI GeneCards UniProt Show fit	prostaglandin-endoperoxide synthase 1
chr4_-_151015713 Show fit	1.66	ENST00000357115.9	LRBA Ensembl NCBI GeneCards UniProt Show fit	LPS responsive beige-like anchor protein
chr15_-_34337719 Show fit	1.63	ENST00000559484.1 ENST00000558589.5 ENST00000458406.6	SLC12A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 6
chr4_-_151015263 Show fit	1.63	ENST00000510413.5 ENST00000507224.5 ENST00000651943.2	LRBA Ensembl NCBI GeneCards UniProt Show fit	LPS responsive beige-like anchor protein
chr17_-_18258556 Show fit	1.63	ENST00000579294.5 ENST00000628188.1 ENST00000545457.6 ENST00000578558.5 ENST00000327031.9	FLII Ensembl NCBI GeneCards UniProt Show fit	FLII actin remodeling protein
chr10_+_11165475 Show fit	1.62	ENST00000609692.5 ENST00000354897.3	CELF2 Ensembl NCBI GeneCards UniProt Show fit	CUGBP Elav-like family member 2
chr9_-_136410599 Show fit	1.62	ENST00000371725.7 ENST00000298537.11 ENST00000357365.8	ENTR1 Ensembl NCBI GeneCards UniProt Show fit	endosome associated trafficking regulator 1
chr3_+_12288838 Show fit	1.62	ENST00000455517.6 ENST00000681982.1	PPARG Ensembl NCBI GeneCards UniProt Show fit	peroxisome proliferator activated receptor gamma
chr2_-_164842011 Show fit	1.59	ENST00000409184.8 ENST00000456693.5	COBLL1 Ensembl NCBI GeneCards UniProt Show fit	cordon-bleu WH2 repeat protein like 1
chr3_-_15333152 Show fit	1.58	ENST00000426925.5	SH3BP5 Ensembl NCBI GeneCards UniProt Show fit	SH3 domain binding protein 5
chr2_-_99489955 Show fit	1.57	ENST00000393445.7 ENST00000258428.8	REV1 Ensembl NCBI GeneCards UniProt Show fit	REV1 DNA directed polymerase
chr7_+_2244476 Show fit	1.56	ENST00000397049.2	NUDT1 Ensembl NCBI GeneCards UniProt Show fit	nudix hydrolase 1
chr5_+_172905217 Show fit	1.53	ENST00000518247.5 ENST00000326654.6	ERGIC1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum-golgi intermediate compartment 1
chr21_+_43719095 Show fit	1.51	ENST00000468090.5 ENST00000291565.9	PDXK Ensembl NCBI GeneCards UniProt Show fit	pyridoxal kinase
chr1_+_44746401 Show fit	1.50	ENST00000372217.5	KIF2C Ensembl NCBI GeneCards UniProt Show fit	kinesin family member 2C
chr6_+_13272709 Show fit	1.50	ENST00000379335.8	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr3_+_12289061 Show fit	1.44	ENST00000652522.1 ENST00000652431.1 ENST00000652098.1 ENST00000651735.1 ENST00000397026.7	PPARG Ensembl NCBI GeneCards UniProt Show fit	peroxisome proliferator activated receptor gamma
chr21_+_37366744 Show fit	1.44	ENST00000647188.2	DYRK1A Ensembl NCBI GeneCards UniProt Show fit	dual specificity tyrosine phosphorylation regulated kinase 1A
chr21_+_37366894 Show fit	1.43	ENST00000647504.1	DYRK1A Ensembl NCBI GeneCards UniProt Show fit	dual specificity tyrosine phosphorylation regulated kinase 1A
chr17_-_7242156 Show fit	1.42	ENST00000571129.5 ENST00000571253.1 ENST00000573928.1 ENST00000302386.10	GABARAP Ensembl NCBI GeneCards UniProt Show fit	GABA type A receptor-associated protein
chr3_+_25790076 Show fit	1.40	ENST00000280701.8 ENST00000420173.2	OXSM Ensembl NCBI GeneCards UniProt Show fit	3-oxoacyl-ACP synthase, mitochondrial
chr3_+_45026296 Show fit	1.39	ENST00000296130.5	CLEC3B Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain family 3 member B
chrX_+_9465011 Show fit	1.31	ENST00000645353.2	TBL1X Ensembl NCBI GeneCards UniProt Show fit	transducin beta like 1 X-linked
chrX_-_40096190 Show fit	1.31	ENST00000679513.1	BCOR Ensembl NCBI GeneCards UniProt Show fit	BCL6 corepressor
chr1_-_84574407 Show fit	1.31	ENST00000370630.6	CTBS Ensembl NCBI GeneCards UniProt Show fit	chitobiase
chrX_+_119468436 Show fit	1.30	ENST00000317881.9	SLC25A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 25 member 5
chr13_-_113864062 Show fit	1.29	ENST00000327773.7	GAS6 Ensembl NCBI GeneCards UniProt Show fit	growth arrest specific 6
chr15_-_34338033 Show fit	1.29	ENST00000558667.5 ENST00000561120.5 ENST00000559236.5 ENST00000397702.6	SLC12A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 6
chrX_-_40177213 Show fit	1.28	ENST00000672922.2 ENST00000378455.8 ENST00000342274.8	BCOR Ensembl NCBI GeneCards UniProt Show fit	BCL6 corepressor
chr22_-_23974441 Show fit	1.28	ENST00000398344.9 ENST00000403754.7 ENST00000430101.2	DDT Ensembl NCBI GeneCards UniProt Show fit	D-dopachrome tautomerase
chrX_-_136780925 Show fit	1.27	ENST00000250617.7	ARHGEF6 Ensembl NCBI GeneCards UniProt Show fit	Rac/Cdc42 guanine nucleotide exchange factor 6
chr17_+_35844077 Show fit	1.26	ENST00000604694.1	TAF15 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 15
chr14_+_22052503 Show fit	1.23	ENST00000390449.3	TRAV21 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor alpha variable 21
chr22_+_29767351 Show fit	1.23	ENST00000330029.6 ENST00000401406.3	UQCR10 Ensembl NCBI GeneCards UniProt Show fit	ubiquinol-cytochrome c reductase, complex III subunit X
chr19_+_49363074 Show fit	1.20	ENST00000597873.5	DKKL1 Ensembl NCBI GeneCards UniProt Show fit	dickkopf like acrosomal protein 1
chr2_-_191151568 Show fit	1.19	ENST00000358470.8 ENST00000432798.1 ENST00000450994.1	STAT4 Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 4
chr19_-_51026593 Show fit	1.16	ENST00000600362.5 ENST00000453757.8 ENST00000601671.1	KLK11 Ensembl NCBI GeneCards UniProt Show fit	kallikrein related peptidase 11
chr16_-_46973634 Show fit	1.15	ENST00000317089.10	DNAJA2 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member A2
chr9_+_36572854 Show fit	1.14	ENST00000543751.5 ENST00000536860.5 ENST00000541717.4 ENST00000536329.5 ENST00000536987.5 ENST00000298048.7 ENST00000495529.5 ENST00000545008.5	MELK Ensembl NCBI GeneCards UniProt Show fit	maternal embryonic leucine zipper kinase
chr8_+_109540602 Show fit	1.11	ENST00000530629.5 ENST00000620557.4	EBAG9 Ensembl NCBI GeneCards UniProt Show fit	estrogen receptor binding site associated antigen 9
chr11_-_30586344 Show fit	1.10	ENST00000358117.10	MPPED2 Ensembl NCBI GeneCards UniProt Show fit	metallophosphoesterase domain containing 2
chr15_-_31101707 Show fit	1.10	ENST00000397795.6 ENST00000256552.11 ENST00000559179.2	TRPM1 Ensembl NCBI GeneCards UniProt Show fit	transient receptor potential cation channel subfamily M member 1
chr6_-_31542339 Show fit	1.08	ENST00000458640.5	DDX39B Ensembl NCBI GeneCards UniProt Show fit	DExD-box helicase 39B
chr11_-_30586272 Show fit	1.08	ENST00000448418.6	MPPED2 Ensembl NCBI GeneCards UniProt Show fit	metallophosphoesterase domain containing 2
chr3_+_184319677 Show fit	1.08	ENST00000441154.5	EIF4G1 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 4 gamma 1
chr22_+_39502320 Show fit	1.07	ENST00000404569.5	MIEF1 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial elongation factor 1
chr14_+_80955577 Show fit	1.05	ENST00000642209.1 ENST00000298171.7	TSHR Ensembl NCBI GeneCards UniProt Show fit	thyroid stimulating hormone receptor
chr3_+_184320283 Show fit	1.02	ENST00000428387.5 ENST00000434061.6	EIF4G1 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 4 gamma 1
chr6_-_88963573 Show fit	1.01	ENST00000369485.9	RNGTT Ensembl NCBI GeneCards UniProt Show fit	RNA guanylyltransferase and 5'-phosphatase
chr1_+_93079264 Show fit	1.00	ENST00000370298.9 ENST00000370303.4	MTF2 Ensembl NCBI GeneCards UniProt Show fit	metal response element binding transcription factor 2
chr14_+_80955650 Show fit	1.00	ENST00000554263.5 ENST00000554435.1	TSHR Ensembl NCBI GeneCards UniProt Show fit	thyroid stimulating hormone receptor
chr7_-_92246045 Show fit	0.99	ENST00000394507.5 ENST00000458177.6 ENST00000340022.6 ENST00000444960.5	KRIT1 Ensembl NCBI GeneCards UniProt Show fit	KRIT1 ankyrin repeat containing
chr11_-_30586866 Show fit	0.94	ENST00000528686.2	MPPED2 Ensembl NCBI GeneCards UniProt Show fit	metallophosphoesterase domain containing 2
chrX_-_30309387 Show fit	0.93	ENST00000378970.5	NR0B1 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 0 group B member 1
chr20_+_48921775 Show fit	0.91	ENST00000681021.1 ENST00000679436.1	ARFGEF2 Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor guanine nucleotide exchange factor 2
chr19_-_3062464 Show fit	0.89	ENST00000327141.9	TLE5 Ensembl NCBI GeneCards UniProt Show fit	TLE family member 5, transcriptional modulator
chr11_-_59810750 Show fit	0.89	ENST00000300151.5	MRPL16 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L16
chr18_+_63476927 Show fit	0.89	ENST00000489441.5 ENST00000382771.9 ENST00000424602.1	SERPINB5 Ensembl NCBI GeneCards UniProt Show fit	serpin family B member 5
chr17_-_28897724 Show fit	0.88	ENST00000394908.9	FLOT2 Ensembl NCBI GeneCards UniProt Show fit	flotillin 2
chr11_+_72224751 Show fit	0.86	ENST00000298229.7	INPPL1 Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate phosphatase like 1
chr2_+_86199355 Show fit	0.85	ENST00000254644.12 ENST00000605125.5 ENST00000337109.9 ENST00000409180.1	MRPL35 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L35
chr11_+_7513966 Show fit	0.85	ENST00000299492.9	PPFIBP2 Ensembl NCBI GeneCards UniProt Show fit	PPFIA binding protein 2
chr14_-_24609660 Show fit	0.85	ENST00000557220.6 ENST00000216338.9 ENST00000382548.4	GZMH Ensembl NCBI GeneCards UniProt Show fit	granzyme H
chr10_+_11742361 Show fit	0.85	ENST00000379215.9 ENST00000420401.5	ECHDC3 Ensembl NCBI GeneCards UniProt Show fit	enoyl-CoA hydratase domain containing 3
chr3_+_37861926 Show fit	0.84	ENST00000443503.6	CTDSPL Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like
chr16_+_31355215 Show fit	0.84	ENST00000562522.2	ITGAX Ensembl NCBI GeneCards UniProt Show fit	integrin subunit alpha X
chrX_+_71301742 Show fit	0.82	ENST00000373829.8 ENST00000538820.1	ITGB1BP2 Ensembl NCBI GeneCards UniProt Show fit	integrin subunit beta 1 binding protein 2
chr17_-_7241787 Show fit	0.82	ENST00000577035.5	GABARAP Ensembl NCBI GeneCards UniProt Show fit	GABA type A receptor-associated protein
chr14_+_80955366 Show fit	0.82	ENST00000342443.10	TSHR Ensembl NCBI GeneCards UniProt Show fit	thyroid stimulating hormone receptor
chr11_-_62984690 Show fit	0.81	ENST00000421062.2 ENST00000458333.6	SLC22A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22 member 6
chr3_+_49021071 Show fit	0.79	ENST00000395458.6	NDUFAF3 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase complex assembly factor 3
chr17_-_2711633 Show fit	0.77	ENST00000435359.5	CLUH Ensembl NCBI GeneCards UniProt Show fit	clustered mitochondria homolog
chr1_-_103108468 Show fit	0.77	ENST00000512756.5 ENST00000461720.6 ENST00000358392.6 ENST00000353414.8	COL11A1 Ensembl NCBI GeneCards UniProt Show fit	collagen type XI alpha 1 chain
chr17_-_28897602 Show fit	0.77	ENST00000394906.6 ENST00000585169.5	FLOT2 Ensembl NCBI GeneCards UniProt Show fit	flotillin 2
chr17_+_5486285 Show fit	0.77	ENST00000576988.1 ENST00000576570.5 ENST00000573759.1	MIS12 Ensembl NCBI GeneCards UniProt Show fit	MIS12 kinetochore complex component
chr11_-_83682414 Show fit	0.76	ENST00000404783.7	DLG2 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 2
chr3_-_9986682 Show fit	0.75	ENST00000429759.5	EMC3 Ensembl NCBI GeneCards UniProt Show fit	ER membrane protein complex subunit 3
chr14_+_22495890 Show fit	0.75	ENST00000390494.1	TRAJ43 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor alpha joining 43
chr6_-_31815244 Show fit	0.75	ENST00000375654.5	HSPA1L Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family A (Hsp70) member 1 like
chr1_-_155910881 Show fit	0.74	ENST00000609492.1 ENST00000368322.7	RIT1 Ensembl NCBI GeneCards UniProt Show fit	Ras like without CAAX 1
chr2_-_49154507 Show fit	0.74	ENST00000406846.7	FSHR Ensembl NCBI GeneCards UniProt Show fit	follicle stimulating hormone receptor
chr17_+_48107743 Show fit	0.72	ENST00000359238.7 ENST00000582104.5 ENST00000584335.5	SNX11 Ensembl NCBI GeneCards UniProt Show fit	sorting nexin 11

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.6	50.6	GO:0060267	positive regulation of respiratory burst(GO:0060267)
2.6	20.8	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
2.1	14.5	GO:1901315	negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.6	4.8	GO:2000417	negative regulation of eosinophil migration(GO:2000417)
1.6	6.3	GO:1904045	cellular response to aldosterone(GO:1904045)
1.5	5.8	GO:1903755	regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755)
1.4	10.0	GO:2000230	negative regulation of pancreatic stellate cell proliferation(GO:2000230)
1.4	5.5	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.3	6.5	GO:0061083	regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
1.2	4.7	GO:0035610	protein side chain deglutamylation(GO:0035610)
1.2	158.9	GO:0030449	regulation of complement activation(GO:0030449)
1.2	10.4	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
1.2	3.5	GO:0098905	regulation of bundle of His cell action potential(GO:0098905)
1.0	7.0	GO:0071477	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.0	5.8	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.9	2.7	GO:1900060	negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060)
0.9	20.0	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.9	2.6	GO:0003218	cardiac left ventricle formation(GO:0003218)
0.8	2.5	GO:1903926	signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.8	3.2	GO:0000415	negative regulation of histone H3-K36 methylation(GO:0000415)
0.7	6.5	GO:1990668	vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane(GO:1990668)
0.7	2.9	GO:1904588	cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.7	3.5	GO:0035905	N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.7	16.5	GO:0044130	negative regulation of growth of symbiont in host(GO:0044130)
0.6	2.6	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.6	1.9	GO:0061074	neuroblast differentiation(GO:0014016) regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
0.5	4.1	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051343)
0.5	1.5	GO:0042822	pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.5	1.4	GO:0001545	primary ovarian follicle growth(GO:0001545)
0.4	1.8	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) prostate gland stromal morphogenesis(GO:0060741) epithelial cell maturation involved in prostate gland development(GO:0060743)
0.4	1.3	GO:0098507	polynucleotide 5' dephosphorylation(GO:0098507)
0.4	1.3	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.4	1.7	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.4	6.1	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.4	65.8	GO:0002377	immunoglobulin production(GO:0002377)
0.4	1.1	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.3	7.9	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3	3.8	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.3	5.5	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.3	5.0	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.3	2.4	GO:0070862	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.3	6.6	GO:0050855	regulation of B cell receptor signaling pathway(GO:0050855)
0.3	2.3	GO:0046146	tetrahydrobiopterin biosynthetic process(GO:0006729) regulation of lung blood pressure(GO:0014916) tetrahydrobiopterin metabolic process(GO:0046146)
0.3	5.2	GO:0021873	forebrain neuroblast division(GO:0021873)
0.3	3.8	GO:0000492	box C/D snoRNP assembly(GO:0000492)
0.3	4.8	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.3	1.9	GO:0080009	mRNA methylation(GO:0080009)
0.3	2.9	GO:0007144	female meiosis I(GO:0007144)
0.3	2.1	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.2	3.1	GO:1901750	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2	2.3	GO:0033227	dsRNA transport(GO:0033227)
0.2	1.8	GO:0002667	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.2	1.1	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.2	1.3	GO:0015853	adenine transport(GO:0015853)
0.2	4.5	GO:0046069	cGMP catabolic process(GO:0046069)
0.2	1.8	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.2	1.6	GO:0006203	dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.2	0.7	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.2	0.7	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)
0.2	1.4	GO:0035989	tendon development(GO:0035989)
0.2	1.9	GO:0002857	positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.2	1.5	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2	0.6	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)
0.2	1.4	GO:0046459	short-chain fatty acid metabolic process(GO:0046459)
0.1	1.6	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.1	3.1	GO:0048311	mitochondrion distribution(GO:0048311)
0.1	1.2	GO:0017062	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1	0.4	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1	2.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.1	2.8	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.1	0.5	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.1	1.4	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.1	2.5	GO:0060213	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1	1.3	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1	3.7	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1	1.6	GO:0051014	actin filament severing(GO:0051014)
0.1	0.3	GO:2001303	lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.1	19.2	GO:0002576	platelet degranulation(GO:0002576)
0.1	0.3	GO:1903565	negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1	1.6	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.1	0.9	GO:0033327	Leydig cell differentiation(GO:0033327)
0.1	0.6	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.1	1.9	GO:0061436	establishment of skin barrier(GO:0061436)
0.1	0.6	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.1	1.1	GO:0046548	retinal rod cell development(GO:0046548)
0.1	1.7	GO:0030513	positive regulation of BMP signaling pathway(GO:0030513)
0.1	0.3	GO:1990737	response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1	0.5	GO:1905068	arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1	3.9	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.1	0.2	GO:0007500	mesodermal cell fate determination(GO:0007500) negative regulation of intracellular transport of viral material(GO:1901253)
0.1	3.4	GO:0001881	receptor recycling(GO:0001881)
0.1	0.8	GO:0034501	protein localization to kinetochore(GO:0034501)
0.1	0.9	GO:0060512	prostate gland morphogenesis(GO:0060512)
0.1	0.6	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.1	1.4	GO:0090141	positive regulation of mitochondrial fission(GO:0090141)
0.0	0.1	GO:0060128	mesodermal cell migration(GO:0008078) corticotropin hormone secreting cell differentiation(GO:0060128)
0.0	1.6	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	1.0	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.3	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.4	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	1.5	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	10.4	GO:0030323	respiratory tube development(GO:0030323)
0.0	15.6	GO:0002250	adaptive immune response(GO:0002250)
0.0	2.9	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	1.8	GO:0071431	tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0	0.2	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.3	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.7	GO:0050812	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	1.9	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	1.3	GO:0042438	melanin biosynthetic process(GO:0042438)
0.0	0.4	GO:0010764	negative regulation of fibroblast migration(GO:0010764)
0.0	0.2	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.3	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.0	1.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.3	GO:2001023	regulation of response to drug(GO:2001023)
0.0	2.5	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0	0.2	GO:0034398	telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.9	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.8	GO:0019835	cytolysis(GO:0019835)
0.0	0.3	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	3.8	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0	2.1	GO:0002062	chondrocyte differentiation(GO:0002062)
0.0	0.8	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.2	GO:0006600	creatine metabolic process(GO:0006600)
0.0	1.2	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349)
0.0	0.4	GO:0006105	succinate metabolic process(GO:0006105)
0.0	0.3	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0	0.4	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.6	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.1	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.7	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	1.1	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	1.0	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0	0.2	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	3.2	GO:0016579	protein deubiquitination(GO:0016579)
0.0	0.5	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.4	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.0	0.2	GO:0048484	enteric nervous system development(GO:0048484)
0.0	1.2	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0	0.4	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.2	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
16.9	50.6	GO:0071750	dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752)
1.7	10.4	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
1.5	76.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
1.5	5.8	GO:1990356	sumoylated E2 ligase complex(GO:1990356)
1.3	6.5	GO:0042825	TAP complex(GO:0042825)
0.9	5.5	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.8	5.7	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.7	2.7	GO:0017059	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.6	3.4	GO:0005879	axonemal microtubule(GO:0005879) asymmetric synapse(GO:0032279)
0.5	4.0	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.5	1.4	GO:0005592	collagen type XI trimer(GO:0005592)
0.5	11.8	GO:0001891	phagocytic cup(GO:0001891)
0.4	5.0	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.4	6.1	GO:0070578	RISC-loading complex(GO:0070578)
0.4	3.8	GO:0097255	R2TP complex(GO:0097255)
0.4	4.6	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.4	1.9	GO:0036396	MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.4	26.9	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.3	8.0	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.3	1.3	GO:0071817	MMXD complex(GO:0071817)
0.3	3.8	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3	2.6	GO:0001520	outer dense fiber(GO:0001520)
0.3	1.4	GO:0001652	granular component(GO:0001652)
0.3	1.1	GO:0035841	new growing cell tip(GO:0035841)
0.2	2.4	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.2	10.1	GO:0002102	podosome(GO:0002102)
0.2	1.8	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2	0.8	GO:0000818	nuclear MIS12/MIND complex(GO:0000818)
0.2	2.8	GO:0031080	nuclear pore outer ring(GO:0031080)
0.2	1.1	GO:0005687	U4 snRNP(GO:0005687)
0.1	2.6	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1	22.2	GO:0072562	blood microparticle(GO:0072562)
0.1	2.2	GO:0097225	sperm midpiece(GO:0097225)
0.1	0.7	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	1.9	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	1.6	GO:0016600	flotillin complex(GO:0016600)
0.1	20.8	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1	0.3	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1	0.9	GO:0042788	polysomal ribosome(GO:0042788)
0.1	0.7	GO:0072546	ER membrane protein complex(GO:0072546)
0.1	0.4	GO:0045273	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1	7.0	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.1	6.6	GO:0016234	inclusion body(GO:0016234)
0.1	12.7	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.1	1.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.5	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	1.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	3.1	GO:0001772	immunological synapse(GO:0001772)
0.0	2.9	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	1.7	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	5.7	GO:0005923	bicellular tight junction(GO:0005923)
0.0	58.8	GO:0005615	extracellular space(GO:0005615)
0.0	1.7	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	10.4	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	13.5	GO:0016607	nuclear speck(GO:0016607)
0.0	0.4	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	1.7	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	0.7	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.4	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	1.5	GO:0005871	kinesin complex(GO:0005871)
0.0	1.9	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	1.5	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.6	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	1.3	GO:0005876	spindle microtubule(GO:0005876)
0.0	1.5	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	0.8	GO:0031519	PcG protein complex(GO:0031519)
0.0	3.7	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.0	0.6	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.5	GO:0001533	cornified envelope(GO:0001533)
0.0	0.3	GO:0045095	keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	20.8	GO:0071933	Arp2/3 complex binding(GO:0071933)
2.2	6.5	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433)
2.1	127.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
1.6	18.0	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
1.5	5.8	GO:0061656	SUMO conjugating enzyme activity(GO:0061656)
1.0	10.0	GO:0050692	DBD domain binding(GO:0050692)
1.0	8.9	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.8	151.4	GO:0003823	antigen binding(GO:0003823)
0.8	3.9	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.8	3.8	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.7	4.5	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.6	6.1	GO:0070883	pre-miRNA binding(GO:0070883)
0.5	1.6	GO:0044713	GTP diphosphatase activity(GO:0036219) 2-hydroxy-adenosine triphosphate pyrophosphatase activity(GO:0044713) 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity(GO:0044714) ATP diphosphatase activity(GO:0047693)
0.5	1.5	GO:0031403	lithium ion binding(GO:0031403)
0.5	6.5	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.5	7.0	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.5	5.0	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5	4.8	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.5	5.6	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.5	1.4	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.5	1.4	GO:0004963	follicle-stimulating hormone receptor activity(GO:0004963)
0.4	1.3	GO:0004651	polynucleotide 5'-phosphatase activity(GO:0004651)
0.4	3.5	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.4	4.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.4	2.3	GO:0019238	cyclohydrolase activity(GO:0019238)
0.4	2.3	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.4	2.9	GO:0004996	thyroid-stimulating hormone receptor activity(GO:0004996)
0.3	1.7	GO:0004666	prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3	0.7	GO:0016418	S-acetyltransferase activity(GO:0016418)
0.3	1.3	GO:0015207	ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.3	13.9	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.3	5.0	GO:0031996	thioesterase binding(GO:0031996)
0.2	3.1	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.2	1.9	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2	0.6	GO:0004056	argininosuccinate lyase activity(GO:0004056)
0.2	5.5	GO:0042288	MHC class I protein binding(GO:0042288)
0.2	1.5	GO:0019237	centromeric DNA binding(GO:0019237)
0.2	4.7	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.2	1.2	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1	0.4	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1	1.1	GO:0030621	U4 snRNA binding(GO:0030621)
0.1	1.3	GO:0004568	chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.1	3.0	GO:0048156	tau protein binding(GO:0048156)
0.1	1.9	GO:0001222	transcription corepressor binding(GO:0001222)
0.1	2.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	3.4	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.1	2.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	1.0	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.3	GO:0047977	hepoxilin-epoxide hydrolase activity(GO:0047977)
0.1	0.4	GO:0051538	succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.1	0.7	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.1	15.3	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	0.6	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1	0.3	GO:0070984	SET domain binding(GO:0070984)
0.1	0.9	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1	12.2	GO:0008565	protein transporter activity(GO:0008565)
0.1	4.6	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1	3.5	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	0.3	GO:0004920	type I interferon receptor activity(GO:0004905) interleukin-10 receptor activity(GO:0004920)
0.1	1.8	GO:0004622	lysophospholipase activity(GO:0004622)
0.1	2.3	GO:0003785	actin monomer binding(GO:0003785)
0.1	1.3	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.7	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.1	2.1	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.4	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	8.3	GO:0005178	integrin binding(GO:0005178)
0.0	4.7	GO:0031072	heat shock protein binding(GO:0031072)
0.0	8.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	0.1	GO:0015140	malate transmembrane transporter activity(GO:0015140)
0.0	1.6	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.3	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.9	GO:0000217	DNA secondary structure binding(GO:0000217)
0.0	0.5	GO:0000150	recombinase activity(GO:0000150)
0.0	1.8	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.2	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.4	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.0	5.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	3.3	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	1.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	2.6	GO:0020037	heme binding(GO:0020037)
0.0	3.3	GO:0051015	actin filament binding(GO:0051015)
0.0	0.3	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0010465	nerve growth factor receptor activity(GO:0010465)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	1.4	GO:0019003	GDP binding(GO:0019003)
0.0	1.6	GO:0003684	damaged DNA binding(GO:0003684)
0.0	1.3	GO:0008013	beta-catenin binding(GO:0008013)
0.0	0.6	GO:0005080	protein kinase C binding(GO:0005080)
0.0	6.0	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	8.4	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	1.1	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	2.3	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	1.1	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.7	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	1.4	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.8	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
0.0	0.9	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.8	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.2	16.5	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.2	2.9	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	30.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	9.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.2	6.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	8.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	12.4	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	3.8	PID MYC PATHWAY	C-MYC pathway
0.1	8.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	2.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	0.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.1	2.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	1.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.1	2.1	PID INSULIN PATHWAY	Insulin Pathway
0.1	2.9	PID ARF6 PATHWAY	Arf6 signaling events
0.1	8.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	0.5	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.9	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	3.4	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	1.5	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.8	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	2.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.6	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.7	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.7	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.6	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	2.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	1.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.8	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.4	4.8	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.3	4.3	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.3	20.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	11.0	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.2	19.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	1.8	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.2	3.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2	8.0	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.1	2.5	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	2.9	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	2.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	5.8	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	4.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	2.3	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	4.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	4.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.3	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.1	8.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	7.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	3.0	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	3.1	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.1	14.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	1.5	REACTOME KINESINS	Genes involved in Kinesins
0.1	1.0	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	1.9	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	2.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	1.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	4.4	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
0.0	0.7	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.7	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.9	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.7	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.4	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.7	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.0	1.8	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.6	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	1.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.5	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	2.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	0.4	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	1.7	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds

Results for THRA_RXRB

Z-value: 0.40

Motif logo

Transcription factors associated with THRA_RXRB

Activity-expression correlation:

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: