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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UAAGACU

Z-value: 0.63

Motif logo

logo of

miRNA associated with seed UAAGACU

NamemiRBASE accession
hsa-miR-499a-5p
MIMAT0002870

Activity profile of UAAGACU motif

Sorted Z-values of UAAGACU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UAAGACU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_140176970 1.85 ENST00000397560.7
KDM7A
lysine demethylase 7A
chrX_+_16719595 1.74 ENST00000380155.4
SYAP1
synapse associated protein 1
chr3_-_18425295 1.73 ENST00000338745.11
ENST00000450898.1
SATB1
SATB homeobox 1
chr18_-_61892997 1.73 ENST00000312828.4
RNF152
ring finger protein 152
chr10_+_110871903 1.56 ENST00000280154.12
PDCD4
programmed cell death 4
chrY_+_12904860 1.42 ENST00000336079.8
DDX3Y
DEAD-box helicase 3 Y-linked
chr5_-_131796921 1.32 ENST00000307968.11
ENST00000307954.12
FNIP1
folliculin interacting protein 1
chr5_+_55738017 1.32 ENST00000514278.6
ENST00000353507.9
ENST00000506511.5
ENST00000505374.6
ENST00000515709.5
ENST00000506848.5
ENST00000514679.5
DDX4
DEAD-box helicase 4
chr13_+_49997019 1.32 ENST00000420995.6
ENST00000356017.8
ENST00000378182.4
ENST00000457662.2
TRIM13
tripartite motif containing 13
chr14_-_99272184 1.30 ENST00000357195.8
BCL11B
BAF chromatin remodeling complex subunit BCL11B
chr3_+_43286512 1.28 ENST00000454177.5
ENST00000429705.6
ENST00000296088.12
ENST00000437827.1
SNRK
SNF related kinase
chr2_-_86337654 1.27 ENST00000165698.9
REEP1
receptor accessory protein 1
chr8_+_55102012 1.12 ENST00000327381.7
XKR4
XK related 4
chr1_-_107965009 0.92 ENST00000527011.5
ENST00000370056.9
VAV3
vav guanine nucleotide exchange factor 3
chr14_-_50231570 0.81 ENST00000216373.10
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2
chr5_-_79991237 0.80 ENST00000512560.5
ENST00000509852.6
ENST00000512528.3
ENST00000617335.4
MTX3
metaxin 3
chr7_-_105388881 0.78 ENST00000460391.5
ENST00000393651.8
SRPK2
SRSF protein kinase 2
chr2_+_119759875 0.78 ENST00000263708.7
PTPN4
protein tyrosine phosphatase non-receptor type 4
chr11_-_128522264 0.76 ENST00000531611.5
ETS1
ETS proto-oncogene 1, transcription factor
chr7_+_139231225 0.62 ENST00000473989.8
UBN2
ubinuclein 2
chr10_+_61901678 0.60 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr9_+_79571767 0.60 ENST00000376544.7
TLE4
TLE family member 4, transcriptional corepressor
chr8_+_11704151 0.58 ENST00000526716.5
ENST00000532059.6
ENST00000335135.8
ENST00000622443.3
GATA4
GATA binding protein 4
chr6_+_21593742 0.58 ENST00000244745.4
SOX4
SRY-box transcription factor 4
chr1_+_42682388 0.54 ENST00000321358.12
ENST00000332220.10
YBX1
Y-box binding protein 1
chr9_-_23821275 0.53 ENST00000380110.8
ELAVL2
ELAV like RNA binding protein 2
chr13_-_106568107 0.53 ENST00000400198.8
ARGLU1
arginine and glutamate rich 1
chr1_-_16352420 0.52 ENST00000375592.8
FBXO42
F-box protein 42
chr8_+_42896883 0.50 ENST00000307602.9
HOOK3
hook microtubule tethering protein 3
chr14_+_103334176 0.47 ENST00000560338.5
ENST00000560763.5
ENST00000216554.8
EIF5
eukaryotic translation initiation factor 5
chr3_-_15332526 0.46 ENST00000383791.8
SH3BP5
SH3 domain binding protein 5
chr1_-_154870264 0.45 ENST00000618040.4
ENST00000271915.9
KCNN3
potassium calcium-activated channel subfamily N member 3
chr3_+_186783567 0.45 ENST00000323963.10
ENST00000440191.6
EIF4A2
eukaryotic translation initiation factor 4A2
chr12_-_42144823 0.43 ENST00000398675.8
GXYLT1
glucoside xylosyltransferase 1
chr15_-_64356074 0.39 ENST00000634811.1
ENST00000303052.13
ENST00000607537.6
CSNK1G1
casein kinase 1 gamma 1
chr20_+_52972347 0.38 ENST00000371497.10
TSHZ2
teashirt zinc finger homeobox 2
chr2_+_227164607 0.35 ENST00000396578.8
COL4A3
collagen type IV alpha 3 chain
chr6_-_13711817 0.35 ENST00000011619.6
RANBP9
RAN binding protein 9
chr9_+_99105098 0.35 ENST00000374990.6
ENST00000374994.9
ENST00000552516.5
TGFBR1
transforming growth factor beta receptor 1
chr17_+_60600178 0.33 ENST00000629650.2
ENST00000305921.8
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent 1D
chr5_+_122775062 0.30 ENST00000379516.7
ENST00000505934.5
ENST00000514949.1
SNX2
sorting nexin 2
chr7_+_65873068 0.30 ENST00000360768.5
VKORC1L1
vitamin K epoxide reductase complex subunit 1 like 1
chr22_-_46537593 0.27 ENST00000262738.9
ENST00000674500.2
CELSR1
cadherin EGF LAG seven-pass G-type receptor 1
chr14_+_105314711 0.27 ENST00000447393.6
ENST00000547217.5
PACS2
phosphofurin acidic cluster sorting protein 2
chr5_+_112976757 0.27 ENST00000389063.3
DCP2
decapping mRNA 2
chr2_+_66435558 0.27 ENST00000488550.5
MEIS1
Meis homeobox 1
chr22_+_21417357 0.27 ENST00000407464.7
HIC2
HIC ZBTB transcriptional repressor 2
chr4_+_139015751 0.26 ENST00000280614.4
NOCT
nocturnin
chr12_+_67648737 0.25 ENST00000344096.4
ENST00000393555.3
DYRK2
dual specificity tyrosine phosphorylation regulated kinase 2
chr8_+_57994455 0.25 ENST00000361488.7
FAM110B
family with sequence similarity 110 member B
chr15_-_45522747 0.23 ENST00000261867.5
SLC30A4
solute carrier family 30 member 4
chr1_+_96721762 0.22 ENST00000675735.1
ENST00000609116.5
ENST00000674951.1
ENST00000426398.3
ENST00000370197.5
ENST00000370198.5
PTBP2
polypyrimidine tract binding protein 2
chr11_-_86955385 0.22 ENST00000531380.2
FZD4
frizzled class receptor 4
chr13_+_101452629 0.21 ENST00000622834.4
ENST00000545560.6
ENST00000376180.8
ITGBL1
integrin subunit beta like 1
chr9_-_19786928 0.21 ENST00000341998.6
ENST00000286344.3
SLC24A2
solute carrier family 24 member 2
chr17_-_75779758 0.21 ENST00000592643.5
ENST00000591890.5
ENST00000587171.1
ENST00000254810.8
ENST00000589599.5
H3-3B
H3.3 histone B
chr13_+_48975879 0.20 ENST00000492622.6
FNDC3A
fibronectin type III domain containing 3A
chr1_+_35931076 0.19 ENST00000397828.3
ENST00000373191.9
AGO3
argonaute RISC catalytic component 3
chr12_-_92929236 0.19 ENST00000322349.13
EEA1
early endosome antigen 1
chr6_+_37257762 0.19 ENST00000373491.3
TBC1D22B
TBC1 domain family member 22B
chr10_+_96832252 0.17 ENST00000676187.1
ENST00000675687.1
ENST00000676123.1
ENST00000675471.1
ENST00000371103.8
ENST00000421806.4
ENST00000675250.1
ENST00000540664.6
ENST00000676414.1
LCOR
ligand dependent nuclear receptor corepressor
chr5_-_77492309 0.17 ENST00000296679.9
ENST00000507029.5
WDR41
WD repeat domain 41
chr16_+_54930827 0.16 ENST00000394636.9
IRX5
iroquois homeobox 5
chr8_-_88327475 0.16 ENST00000286614.11
MMP16
matrix metallopeptidase 16
chr2_-_71227055 0.16 ENST00000244221.9
PAIP2B
poly(A) binding protein interacting protein 2B
chrX_+_41334154 0.16 ENST00000441189.4
ENST00000644513.1
ENST00000644109.1
ENST00000646122.1
ENST00000644074.1
ENST00000644876.2
ENST00000399959.7
ENST00000646319.1
DDX3X
DEAD-box helicase 3 X-linked
chr8_-_66667138 0.13 ENST00000310421.5
VCPIP1
valosin containing protein interacting protein 1
chr17_-_5486157 0.13 ENST00000572834.5
ENST00000158771.9
ENST00000570848.5
ENST00000571971.1
DERL2
derlin 2
chr1_-_20786610 0.12 ENST00000375000.5
ENST00000312239.10
ENST00000419490.5
ENST00000414993.1
ENST00000443615.1
HP1BP3
heterochromatin protein 1 binding protein 3
chr15_+_100602519 0.12 ENST00000332783.12
ENST00000558747.5
ENST00000343276.4
ASB7
ankyrin repeat and SOCS box containing 7
chr7_-_44885446 0.10 ENST00000395699.5
PURB
purine rich element binding protein B
chr17_-_47189176 0.08 ENST00000531206.5
ENST00000527547.5
ENST00000575483.5
ENST00000066544.8
CDC27
cell division cycle 27
chr16_-_4847265 0.07 ENST00000591451.5
ENST00000436648.9
ENST00000321919.14
ENST00000588297.5
GLYR1
glyoxylate reductase 1 homolog
chr17_+_40062956 0.07 ENST00000450525.7
THRA
thyroid hormone receptor alpha
chr10_-_35642286 0.05 ENST00000374694.3
FZD8
frizzled class receptor 8
chr22_+_29883158 0.05 ENST00000333027.7
ENST00000401950.7
ENST00000445401.5
ENST00000323630.9
ENST00000351488.7
MTMR3
myotubularin related protein 3
chr13_-_49792675 0.04 ENST00000261667.8
KPNA3
karyopherin subunit alpha 3
chr7_+_90596281 0.04 ENST00000380050.8
CDK14
cyclin dependent kinase 14
chr3_+_89107649 0.04 ENST00000452448.6
ENST00000494014.1
EPHA3
EPH receptor A3
chr2_+_176116768 0.03 ENST00000249501.5
HOXD10
homeobox D10
chr2_+_42169332 0.03 ENST00000402711.6
ENST00000318522.10
EML4
EMAP like 4
chr1_-_159714581 0.03 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
CRP
C-reactive protein
chr2_+_176122712 0.02 ENST00000249499.8
HOXD9
homeobox D9
chr10_-_931684 0.02 ENST00000316157.8
LARP4B
La ribonucleoprotein 4B
chr15_+_56918612 0.01 ENST00000438423.6
ENST00000267811.9
ENST00000333725.10
ENST00000559609.5
TCF12
transcription factor 12
chr12_-_12267003 0.01 ENST00000535731.1
ENST00000261349.9
LRP6
LDL receptor related protein 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.5 1.6 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.4 1.3 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.3 1.3 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.2 1.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 1.7 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.6 GO:0035054 atrial septum secundum morphogenesis(GO:0003290) embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.1 0.8 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.6 GO:0035905 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 1.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.3 GO:1905075 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.1 0.8 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.1 0.5 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 1.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 1.3 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.2 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.7 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 2.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.3 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.8 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.6 GO:0016577 histone demethylation(GO:0016577)
0.0 0.0 GO:1902594 viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594)
0.0 0.1 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 0.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0071546 pi-body(GO:0071546)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)
0.1 1.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 1.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.5 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.4 1.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 1.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 1.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.4 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 0.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.6 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.3 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.0 0.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 3.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 1.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.9 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.9 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis