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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UCCAGUU
Z-value: 5.57
Motif logo
miRNA associated with seed UCCAGUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-145-5p
|
MIMAT0000437 |
|
hsa-miR-5195-3p
|
MIMAT0021127 |
Activity profile of UCCAGUU motif
Sorted Z-values of UCCAGUU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of UCCAGUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 11.5 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 3.8 | 11.4 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 3.7 | 11.0 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 3.6 | 10.8 | GO:1904387 | response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387) |
| 3.5 | 10.4 | GO:0060434 | bronchus morphogenesis(GO:0060434) |
| 3.4 | 10.3 | GO:0060435 | bronchiole development(GO:0060435) |
| 2.4 | 9.7 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 2.4 | 7.2 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 2.3 | 9.3 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 2.1 | 8.4 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 2.0 | 8.1 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 2.0 | 19.7 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 2.0 | 9.8 | GO:0044789 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 1.9 | 11.7 | GO:1903677 | regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690) |
| 1.9 | 5.8 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 1.9 | 5.7 | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells(GO:1903691) |
| 1.9 | 5.6 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 1.8 | 5.4 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 1.6 | 4.9 | GO:0034635 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 1.6 | 4.9 | GO:0042704 | negative regulation of alkaline phosphatase activity(GO:0010693) uterine wall breakdown(GO:0042704) |
| 1.6 | 4.8 | GO:0060382 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 1.6 | 4.7 | GO:0042819 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819) |
| 1.6 | 4.7 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 1.4 | 10.9 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 1.2 | 3.7 | GO:0060278 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 1.2 | 11.0 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 1.2 | 8.5 | GO:0060702 | negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) |
| 1.2 | 5.9 | GO:0031291 | Ran protein signal transduction(GO:0031291) |
| 1.2 | 15.0 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 1.1 | 3.3 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 1.1 | 10.8 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 1.1 | 3.2 | GO:0060018 | astrocyte fate commitment(GO:0060018) retinal rod cell differentiation(GO:0060221) |
| 1.1 | 12.7 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 1.1 | 8.5 | GO:1903551 | regulation of extracellular exosome assembly(GO:1903551) |
| 1.0 | 8.3 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 1.0 | 12.9 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 1.0 | 11.7 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.9 | 5.7 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.9 | 7.5 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.9 | 5.6 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.9 | 2.8 | GO:1903826 | arginine transmembrane transport(GO:1903826) |
| 0.9 | 3.6 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 0.9 | 14.8 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.9 | 8.7 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.8 | 11.0 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
| 0.8 | 7.8 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.8 | 2.3 | GO:0048633 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.8 | 12.5 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.8 | 15.4 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.7 | 5.0 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.7 | 7.8 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.7 | 4.9 | GO:0001712 | ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712) |
| 0.7 | 4.9 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.7 | 2.1 | GO:2000547 | dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547) |
| 0.7 | 7.5 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.7 | 2.0 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.7 | 10.6 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) |
| 0.7 | 10.6 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.7 | 2.0 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.6 | 4.4 | GO:0032328 | alanine transport(GO:0032328) |
| 0.6 | 3.0 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.6 | 1.8 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 0.6 | 1.8 | GO:0021764 | amygdala development(GO:0021764) |
| 0.6 | 4.1 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.6 | 6.4 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.6 | 1.1 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.6 | 2.2 | GO:1904504 | regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504) |
| 0.5 | 7.0 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.5 | 1.5 | GO:0036446 | myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) negative regulation of vascular smooth muscle cell differentiation(GO:1905064) |
| 0.5 | 3.0 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.5 | 3.4 | GO:0032417 | positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
| 0.5 | 5.2 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.5 | 8.4 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.5 | 3.7 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.5 | 2.3 | GO:0098917 | retrograde trans-synaptic signaling(GO:0098917) |
| 0.4 | 6.7 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.4 | 3.1 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.4 | 1.2 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.4 | 1.2 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.4 | 2.2 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.4 | 4.0 | GO:0021740 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.4 | 2.1 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.4 | 5.3 | GO:0032025 | response to cobalt ion(GO:0032025) |
| 0.4 | 0.4 | GO:0072106 | regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) |
| 0.3 | 1.0 | GO:0061011 | hepatic duct development(GO:0061011) hepatoblast differentiation(GO:0061017) |
| 0.3 | 5.7 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.3 | 1.7 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) sensory system development(GO:0048880) trigeminal ganglion development(GO:0061551) facioacoustic ganglion development(GO:1903375) |
| 0.3 | 2.6 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.3 | 9.4 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.3 | 4.3 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.3 | 3.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 0.9 | GO:1990519 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 0.3 | 1.2 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.3 | 8.0 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
| 0.3 | 2.3 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.3 | 0.8 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.3 | 2.3 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.3 | 7.6 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.3 | 0.8 | GO:0014740 | negative regulation of muscle hyperplasia(GO:0014740) |
| 0.2 | 0.7 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.2 | 1.5 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.2 | 1.2 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.2 | 7.2 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.2 | 1.7 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.2 | 2.1 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.2 | 3.7 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.2 | 3.8 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 1.8 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.2 | 2.8 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.2 | 4.1 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.2 | 2.1 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.2 | 8.0 | GO:0032094 | response to food(GO:0032094) |
| 0.2 | 7.2 | GO:2000272 | negative regulation of receptor activity(GO:2000272) |
| 0.2 | 0.6 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.2 | 1.4 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.2 | 14.0 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.2 | 6.6 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.2 | 1.6 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.2 | 6.5 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.2 | 9.1 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.2 | 1.1 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.2 | 8.1 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.2 | 1.0 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.2 | 1.7 | GO:0071798 | response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799) |
| 0.2 | 0.7 | GO:0090283 | regulation of protein glycosylation in Golgi(GO:0090283) |
| 0.2 | 35.5 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.2 | 4.1 | GO:0009226 | nucleotide-sugar biosynthetic process(GO:0009226) |
| 0.2 | 0.5 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
| 0.2 | 5.1 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.2 | 10.7 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.2 | 5.9 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.2 | 7.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.2 | 0.8 | GO:1904628 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.2 | 5.6 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.2 | 3.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.3 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
| 0.1 | 2.7 | GO:0003148 | outflow tract septum morphogenesis(GO:0003148) |
| 0.1 | 3.6 | GO:0060148 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.1 | 10.7 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.1 | 0.4 | GO:0043321 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.1 | 0.7 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.1 | 1.4 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 2.5 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.1 | 1.1 | GO:0043297 | apical junction assembly(GO:0043297) |
| 0.1 | 0.6 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.1 | 0.8 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 2.0 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.1 | 3.4 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.1 | 4.6 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.1 | 1.5 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.1 | 0.4 | GO:0042695 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.1 | 0.7 | GO:0044557 | relaxation of smooth muscle(GO:0044557) |
| 0.1 | 6.1 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 0.1 | 0.9 | GO:0051956 | negative regulation of mitochondrial membrane potential(GO:0010917) negative regulation of membrane potential(GO:0045837) negative regulation of amino acid transport(GO:0051956) |
| 0.1 | 1.2 | GO:0002863 | positive regulation of inflammatory response to antigenic stimulus(GO:0002863) |
| 0.1 | 2.4 | GO:0001825 | ribosomal small subunit assembly(GO:0000028) blastocyst formation(GO:0001825) |
| 0.1 | 0.3 | GO:0002101 | tRNA wobble cytosine modification(GO:0002101) |
| 0.1 | 1.9 | GO:2000696 | regulation of epithelial cell differentiation involved in kidney development(GO:2000696) |
| 0.1 | 8.3 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.1 | 1.6 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 1.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 0.7 | GO:0017182 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.1 | 4.6 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.1 | 0.3 | GO:0060268 | negative regulation of respiratory burst(GO:0060268) |
| 0.1 | 1.6 | GO:0042953 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.1 | 0.7 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.1 | 0.8 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.1 | 5.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 1.3 | GO:0035116 | embryonic hindlimb morphogenesis(GO:0035116) |
| 0.1 | 4.3 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 0.1 | 3.0 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.1 | 2.3 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.1 | 1.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 0.4 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.1 | 21.5 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.1 | 0.5 | GO:0023019 | signal transduction involved in regulation of gene expression(GO:0023019) |
| 0.1 | 2.9 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.1 | 0.4 | GO:0060033 | anatomical structure regression(GO:0060033) |
| 0.0 | 0.5 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.0 | 0.5 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.0 | 3.7 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.0 | 0.2 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.0 | 2.7 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 3.2 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.5 | GO:0099514 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 1.2 | GO:0090382 | phagosome maturation(GO:0090382) |
| 0.0 | 3.4 | GO:0016573 | histone acetylation(GO:0016573) |
| 0.0 | 0.3 | GO:0003197 | endocardial cushion development(GO:0003197) |
| 0.0 | 0.4 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 1.5 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 1.9 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 0.8 | GO:0090003 | regulation of establishment of protein localization to plasma membrane(GO:0090003) |
| 0.0 | 0.8 | GO:0001938 | positive regulation of endothelial cell proliferation(GO:0001938) |
| 0.0 | 0.6 | GO:0048704 | embryonic skeletal system morphogenesis(GO:0048704) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 11.0 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 3.6 | 10.8 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 2.8 | 8.5 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 2.6 | 15.8 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 2.1 | 6.3 | GO:0044393 | microspike(GO:0044393) |
| 2.0 | 7.8 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 1.9 | 7.5 | GO:0000811 | GINS complex(GO:0000811) |
| 1.8 | 5.4 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
| 1.7 | 5.2 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 1.6 | 12.7 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 1.5 | 4.5 | GO:0000805 | X chromosome(GO:0000805) |
| 1.5 | 14.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 1.4 | 15.5 | GO:0005638 | lamin filament(GO:0005638) |
| 1.3 | 5.4 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 1.1 | 22.1 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 1.0 | 5.0 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 1.0 | 7.0 | GO:0031415 | NatA complex(GO:0031415) |
| 0.8 | 7.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.7 | 2.0 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.6 | 9.3 | GO:0032059 | bleb(GO:0032059) |
| 0.6 | 4.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.6 | 1.7 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 0.6 | 5.1 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.6 | 2.2 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.5 | 5.6 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.5 | 6.8 | GO:0090543 | Flemming body(GO:0090543) |
| 0.5 | 5.0 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.4 | 7.0 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.4 | 11.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.4 | 4.9 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.4 | 4.3 | GO:0030681 | multimeric ribonuclease P complex(GO:0030681) |
| 0.3 | 6.1 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.3 | 3.4 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.3 | 11.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 3.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.3 | 2.6 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.3 | 1.7 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.3 | 3.6 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.3 | 3.9 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.3 | 24.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.3 | 0.8 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.3 | 2.8 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 22.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 5.9 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 3.0 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.2 | 4.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.2 | 5.1 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.2 | 15.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 3.1 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.2 | 8.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.2 | 1.8 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 0.9 | GO:0000835 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.2 | 7.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.2 | 4.7 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.2 | 0.7 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.2 | 5.4 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.2 | 8.8 | GO:0005844 | polysome(GO:0005844) |
| 0.2 | 8.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 1.1 | GO:0043196 | varicosity(GO:0043196) |
| 0.2 | 2.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 5.9 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.2 | 16.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 2.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 7.8 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 8.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 15.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 1.3 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 8.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 14.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 16.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 4.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.0 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.1 | 0.7 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 1.1 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 3.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 3.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 10.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 5.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 9.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 2.4 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.1 | 0.7 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 3.8 | GO:0031248 | histone acetyltransferase complex(GO:0000123) protein acetyltransferase complex(GO:0031248) acetyltransferase complex(GO:1902493) |
| 0.1 | 5.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.1 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.1 | 4.1 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 1.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 6.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 9.8 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 1.5 | GO:0036379 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.0 | 4.6 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 1.6 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 1.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 2.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 1.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.4 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.3 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 3.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 10.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.3 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 6.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 9.5 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 0.6 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 0.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.3 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 4.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 4.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 1.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.7 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 4.9 | GO:0030529 | intracellular ribonucleoprotein complex(GO:0030529) |
| 0.0 | 11.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.8 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 3.5 | 10.4 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 2.8 | 8.4 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 2.7 | 8.1 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 2.4 | 9.7 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 2.2 | 11.0 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 2.1 | 8.4 | GO:1990189 | peptide-serine-N-acetyltransferase activity(GO:1990189) |
| 1.8 | 7.0 | GO:0047676 | arachidonate-CoA ligase activity(GO:0047676) |
| 1.5 | 17.7 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 1.3 | 5.2 | GO:0019798 | procollagen-proline dioxygenase activity(GO:0019798) |
| 1.3 | 5.1 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 1.3 | 3.8 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 1.2 | 8.5 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 1.1 | 3.4 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 1.0 | 8.3 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.0 | 4.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 1.0 | 4.9 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 1.0 | 4.9 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.9 | 5.6 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.9 | 2.8 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.9 | 9.3 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.9 | 3.7 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.9 | 6.4 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.9 | 5.4 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.9 | 6.9 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.8 | 2.5 | GO:0060001 | minus-end directed microfilament motor activity(GO:0060001) |
| 0.8 | 16.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.8 | 2.3 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.7 | 2.2 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.7 | 7.0 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.7 | 9.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.7 | 4.7 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.6 | 7.9 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.6 | 7.8 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.6 | 1.8 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.6 | 8.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.6 | 1.7 | GO:0004958 | prostaglandin F receptor activity(GO:0004958) |
| 0.5 | 7.5 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.5 | 4.4 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.5 | 4.3 | GO:0018812 | 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) |
| 0.5 | 3.7 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.5 | 8.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.4 | 7.2 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.4 | 1.2 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.4 | 1.9 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.4 | 1.1 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
| 0.4 | 6.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.4 | 14.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.3 | 8.0 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.3 | 3.2 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.3 | 14.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.3 | 10.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.3 | 1.2 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 0.3 | 1.8 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.3 | 5.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.3 | 1.8 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.3 | 0.9 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 0.3 | 2.2 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.3 | 20.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 4.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.2 | 5.4 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.2 | 5.8 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.2 | 8.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.2 | 8.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.2 | 3.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.2 | 0.7 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.2 | 11.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.2 | 1.1 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.2 | 5.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.2 | 1.0 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.2 | 5.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 5.6 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.2 | 22.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.2 | 5.1 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.2 | 8.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.2 | 1.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.2 | 0.7 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.2 | 2.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 4.7 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.2 | 1.0 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.2 | 8.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 0.8 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.2 | 0.8 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.1 | 3.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 2.1 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.1 | 1.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 66.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 1.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.9 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 6.0 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 7.1 | GO:0008026 | ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035) |
| 0.1 | 0.8 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.1 | 11.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 10.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 3.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 5.7 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 3.0 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 1.7 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 2.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.7 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 8.7 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 0.7 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 3.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 9.9 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.1 | 7.3 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 1.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 1.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 13.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 1.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 8.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 2.7 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 0.8 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 7.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 1.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 1.4 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 2.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 34.7 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.1 | 3.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 1.0 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 5.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 10.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.3 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.0 | 17.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 0.3 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.0 | 0.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 1.2 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 0.3 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 0.4 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 3.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 4.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.4 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 0.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 1.6 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 1.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.0 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 13.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.5 | 18.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.5 | 10.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.4 | 27.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.4 | 16.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.3 | 27.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.3 | 10.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.3 | 13.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.3 | 6.8 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.2 | 8.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 30.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 12.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.2 | 3.1 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 5.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 6.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 1.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 3.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 5.1 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 17.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 13.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.6 | PID EPO PATHWAY | EPO signaling pathway |
| 0.1 | 3.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 28.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.4 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 2.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 0.8 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 1.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 0.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 0.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.3 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 10.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.1 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 2.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.0 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 1.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.2 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 8.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.3 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.0 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.5 | 8.1 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.5 | 7.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 10.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 10.2 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.4 | 13.7 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.4 | 8.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.4 | 5.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.4 | 7.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 17.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.3 | 4.5 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.3 | 10.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 3.7 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 4.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.2 | 7.0 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 4.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 5.2 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.2 | 6.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 11.4 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.2 | 5.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 8.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 9.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 5.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 1.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 4.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 4.1 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.2 | 4.4 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.2 | 11.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 5.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 2.1 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 1.7 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.1 | 2.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 4.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 4.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 3.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.6 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 1.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 2.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 1.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 1.2 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 2.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 0.8 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 6.4 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 1.2 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.5 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 5.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 5.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 4.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 5.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 3.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.7 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 2.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 3.1 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.0 | 1.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.1 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 1.0 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 0.3 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |