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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UGACAUC

Z-value: 0.14

Motif logo

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miRNA associated with seed UGACAUC

NamemiRBASE accession
hsa-miR-489-3p
MIMAT0002805

Activity profile of UGACAUC motif

Sorted Z-values of UGACAUC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UGACAUC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_55102012 0.89 ENST00000327381.7
XKR4
XK related 4
chr2_+_30146941 0.69 ENST00000379520.7
ENST00000379519.7
YPEL5
yippee like 5
chrX_+_65667645 0.68 ENST00000360270.7
MSN
moesin
chr6_+_116280098 0.65 ENST00000643175.1
ENST00000452085.7
DSE
dermatan sulfate epimerase
chr12_+_31959406 0.60 ENST00000540924.5
ENST00000312561.9
RESF1
retroelement silencing factor 1
chr1_+_46203321 0.52 ENST00000371980.4
LURAP1
leucine rich adaptor protein 1
chr21_-_15064934 0.42 ENST00000400199.5
ENST00000400202.5
ENST00000318948.7
NRIP1
nuclear receptor interacting protein 1
chr2_-_160493799 0.41 ENST00000348849.8
RBMS1
RNA binding motif single stranded interacting protein 1
chr5_+_136028979 0.38 ENST00000442011.7
TGFBI
transforming growth factor beta induced
chr1_-_70205531 0.38 ENST00000370952.4
LRRC40
leucine rich repeat containing 40
chr3_-_113746218 0.35 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
NAA50
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr1_-_224434750 0.35 ENST00000414423.9
ENST00000678917.1
ENST00000678555.1
ENST00000678307.1
WDR26
WD repeat domain 26
chr9_-_91423819 0.35 ENST00000297689.4
NFIL3
nuclear factor, interleukin 3 regulated
chr6_-_113971120 0.32 ENST00000520895.5
ENST00000521163.5
ENST00000524334.1
ENST00000519065.6
ENST00000368632.6
HDAC2
histone deacetylase 2
chr4_-_102827494 0.31 ENST00000453744.7
ENST00000321805.11
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr6_-_24911029 0.31 ENST00000259698.9
ENST00000644621.1
ENST00000644411.1
RIPOR2
RHO family interacting cell polarization regulator 2
chr2_-_38751350 0.28 ENST00000409276.5
ENST00000313117.11
ENST00000446327.6
SRSF7
serine and arginine rich splicing factor 7
chr10_+_110919595 0.28 ENST00000369452.9
SHOC2
SHOC2 leucine rich repeat scaffold protein
chr10_-_27154226 0.27 ENST00000427324.5
ENST00000375972.7
ENST00000326799.7
YME1L1
YME1 like 1 ATPase
chr18_+_24113341 0.27 ENST00000540918.2
TTC39C
tetratricopeptide repeat domain 39C
chr14_-_21269451 0.26 ENST00000336053.10
HNRNPC
heterogeneous nuclear ribonucleoprotein C
chr3_-_182980531 0.25 ENST00000292782.9
ENST00000632685.1
DCUN1D1
defective in cullin neddylation 1 domain containing 1
chr1_+_91500827 0.24 ENST00000234626.11
CDC7
cell division cycle 7
chr21_-_14383125 0.23 ENST00000285667.4
HSPA13
heat shock protein family A (Hsp70) member 13
chr12_-_102120065 0.23 ENST00000552283.6
ENST00000551744.2
NUP37
nucleoporin 37
chr5_+_109689915 0.21 ENST00000261483.5
MAN2A1
mannosidase alpha class 2A member 1
chr14_+_69611586 0.21 ENST00000342745.5
SUSD6
sushi domain containing 6
chr12_-_122526929 0.20 ENST00000331738.12
ENST00000528279.1
ENST00000344591.8
ENST00000526560.6
RSRC2
arginine and serine rich coiled-coil 2
chr12_-_29381141 0.20 ENST00000546839.5
ENST00000552155.5
ENST00000360150.9
ENST00000550353.5
ENST00000548441.1
ENST00000552132.5
ERGIC2
ERGIC and golgi 2
chr15_-_49155574 0.20 ENST00000558843.5
ENST00000388901.10
ENST00000542928.5
ENST00000561248.1
ENST00000299259.10
COPS2
COP9 signalosome subunit 2
chr17_+_47531052 0.20 ENST00000532729.6
ENST00000322157.9
NPEPPS
aminopeptidase puromycin sensitive
chr12_+_59689337 0.18 ENST00000261187.8
SLC16A7
solute carrier family 16 member 7
chr3_-_72446623 0.18 ENST00000477973.4
RYBP
RING1 and YY1 binding protein
chr5_+_139293728 0.17 ENST00000510056.5
ENST00000511249.5
ENST00000394805.8
ENST00000503811.5
ENST00000618441.5
MATR3
matrin 3
chr13_-_77327050 0.16 ENST00000684354.1
ENST00000682321.1
ENST00000683823.1
ENST00000683697.1
ENST00000357337.11
ENST00000544440.7
MYCBP2
MYC binding protein 2
chr6_+_21593742 0.15 ENST00000244745.4
SOX4
SRY-box transcription factor 4
chr20_-_47355657 0.15 ENST00000311275.11
ZMYND8
zinc finger MYND-type containing 8
chr9_-_6015607 0.15 ENST00000485372.1
ENST00000259569.6
ENST00000623170.1
RANBP6
RAN binding protein 6
chr1_+_111449442 0.15 ENST00000369722.8
ENST00000483994.1
ATP5PB
ATP synthase peripheral stalk-membrane subunit b
chr5_-_173328407 0.15 ENST00000265087.9
STC2
stanniocalcin 2
chr13_+_97953652 0.15 ENST00000460070.6
ENST00000481455.6
ENST00000261574.10
ENST00000651721.2
ENST00000493281.6
ENST00000463157.6
ENST00000471898.5
ENST00000489058.6
ENST00000481689.6
IPO5
importin 5
chrX_-_119852948 0.15 ENST00000276201.7
ENST00000345865.6
UPF3B
UPF3B regulator of nonsense mediated mRNA decay
chr6_+_36027677 0.14 ENST00000622903.4
ENST00000229795.7
MAPK14
mitogen-activated protein kinase 14
chr1_-_113812448 0.14 ENST00000612242.4
ENST00000261441.9
RSBN1
round spermatid basic protein 1
chr15_-_34101807 0.14 ENST00000527822.5
ENST00000528949.1
ENST00000256545.9
EMC7
ER membrane protein complex subunit 7
chr7_-_138981307 0.14 ENST00000440172.5
ENST00000422774.2
KIAA1549
KIAA1549
chr9_+_79571767 0.13 ENST00000376544.7
TLE4
TLE family member 4, transcriptional corepressor
chr9_+_122264857 0.13 ENST00000344641.8
ENST00000441707.5
ENST00000373723.9
ENST00000373729.5
MRRF
mitochondrial ribosome recycling factor
chr7_-_41703062 0.13 ENST00000242208.5
INHBA
inhibin subunit beta A
chr5_-_140346596 0.13 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chr16_-_21652598 0.13 ENST00000569602.1
ENST00000268389.6
IGSF6
immunoglobulin superfamily member 6
chr2_+_28751802 0.12 ENST00000296122.10
ENST00000395366.3
PPP1CB
protein phosphatase 1 catalytic subunit beta
chr6_-_139374605 0.12 ENST00000618718.1
ENST00000367651.4
CITED2
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
chr1_+_26472405 0.11 ENST00000361427.6
HMGN2
high mobility group nucleosomal binding domain 2
chr2_+_197453423 0.11 ENST00000263960.6
COQ10B
coenzyme Q10B
chr9_+_75088498 0.11 ENST00000346234.7
OSTF1
osteoclast stimulating factor 1
chr10_+_68721207 0.11 ENST00000538031.5
ENST00000543719.5
ENST00000539539.5
ENST00000265872.11
ENST00000543225.5
ENST00000536012.5
ENST00000494903.2
CCAR1
cell division cycle and apoptosis regulator 1
chr18_+_9913979 0.11 ENST00000400000.7
ENST00000340541.4
VAPA
VAMP associated protein A
chr1_+_193121950 0.11 ENST00000367435.5
CDC73
cell division cycle 73
chr4_-_120066777 0.11 ENST00000296509.11
MAD2L1
mitotic arrest deficient 2 like 1
chr16_+_53054973 0.10 ENST00000447540.6
ENST00000615216.4
ENST00000566029.5
CHD9
chromodomain helicase DNA binding protein 9
chr8_-_73878816 0.10 ENST00000602593.6
ENST00000651945.1
ENST00000419880.7
ENST00000517608.5
ENST00000650817.1
UBE2W
ubiquitin conjugating enzyme E2 W
chr20_+_48921701 0.10 ENST00000371917.5
ARFGEF2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr1_-_107965009 0.09 ENST00000527011.5
ENST00000370056.9
VAV3
vav guanine nucleotide exchange factor 3
chr10_+_70815889 0.09 ENST00000373202.8
SGPL1
sphingosine-1-phosphate lyase 1
chr4_+_159267737 0.09 ENST00000264431.8
RAPGEF2
Rap guanine nucleotide exchange factor 2
chr14_-_37172553 0.09 ENST00000331299.6
SLC25A21
solute carrier family 25 member 21
chr15_+_58987652 0.08 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr8_-_77000070 0.08 ENST00000357039.9
PEX2
peroxisomal biogenesis factor 2
chr1_-_21783189 0.07 ENST00000400301.5
ENST00000532737.1
USP48
ubiquitin specific peptidase 48
chr8_-_71356653 0.07 ENST00000388742.8
ENST00000388740.4
EYA1
EYA transcriptional coactivator and phosphatase 1
chr2_-_65130090 0.07 ENST00000398529.7
ENST00000409751.1
ENST00000409892.5
ENST00000409784.8
RAB1A
RAB1A, member RAS oncogene family
chr1_+_28668746 0.07 ENST00000361872.8
ENST00000294409.2
ENST00000373816.6
GMEB1
glucocorticoid modulatory element binding protein 1
chr10_+_110207587 0.07 ENST00000332674.9
ENST00000453116.5
MXI1
MAX interactor 1, dimerization protein
chr12_+_54549586 0.07 ENST00000243052.8
PDE1B
phosphodiesterase 1B
chr6_-_99425269 0.07 ENST00000647811.1
ENST00000481229.2
ENST00000369239.10
ENST00000681611.1
ENST00000681615.1
ENST00000438806.5
PNISR
PNN interacting serine and arginine rich protein
chr1_+_50108856 0.06 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAVL4
ELAV like RNA binding protein 4
chr18_-_67516707 0.06 ENST00000310045.9
DSEL
dermatan sulfate epimerase like
chr15_+_68277724 0.06 ENST00000306917.5
FEM1B
fem-1 homolog B
chr8_+_131904071 0.06 ENST00000254624.10
ENST00000522709.5
EFR3A
EFR3 homolog A
chr8_+_31033782 0.06 ENST00000298139.7
WRN
WRN RecQ like helicase
chr7_+_12211259 0.05 ENST00000396668.8
ENST00000444443.5
ENST00000396667.7
TMEM106B
transmembrane protein 106B
chr12_+_130872037 0.05 ENST00000448750.7
ENST00000541630.5
ENST00000543796.6
ENST00000392369.6
ENST00000535090.5
ENST00000541679.7
ENST00000392367.4
RAN
RAN, member RAS oncogene family
chr2_+_165469647 0.05 ENST00000421875.5
ENST00000314499.11
ENST00000409664.5
ENST00000651982.1
CSRNP3
cysteine and serine rich nuclear protein 3
chr5_-_107670897 0.05 ENST00000333274.11
EFNA5
ephrin A5
chr1_-_39672080 0.04 ENST00000235628.2
NT5C1A
5'-nucleotidase, cytosolic IA
chr7_+_31052297 0.04 ENST00000304166.9
ADCYAP1R1
ADCYAP receptor type I
chrX_-_77786198 0.04 ENST00000624032.3
ENST00000624668.3
ENST00000373344.11
ENST00000395603.7
ENST00000624166.3
ENST00000623321.3
ENST00000622960.1
ATRX
ATRX chromatin remodeler
chr1_+_32108035 0.04 ENST00000373625.8
KPNA6
karyopherin subunit alpha 6
chr18_+_34978244 0.04 ENST00000436190.6
MAPRE2
microtubule associated protein RP/EB family member 2
chr3_+_45594727 0.04 ENST00000273317.5
LIMD1
LIM domains containing 1
chr1_-_161177487 0.04 ENST00000367998.5
ENST00000319769.10
B4GALT3
beta-1,4-galactosyltransferase 3
chr3_+_150408314 0.04 ENST00000361875.7
TSC22D2
TSC22 domain family member 2
chr14_+_90397019 0.04 ENST00000447653.8
ENST00000356978.9
ENST00000626705.2
CALM1
calmodulin 1
chr5_-_141618957 0.03 ENST00000389054.8
DIAPH1
diaphanous related formin 1
chr11_+_105610066 0.03 ENST00000282499.10
ENST00000393127.6
ENST00000527669.1
GRIA4
glutamate ionotropic receptor AMPA type subunit 4
chr2_-_171160833 0.03 ENST00000360843.7
ENST00000431350.7
TLK1
tousled like kinase 1
chr9_+_117704382 0.03 ENST00000646089.1
ENST00000355622.8
ENSG00000285082.2
TLR4
novel protein
toll like receptor 4
chr1_+_65264694 0.02 ENST00000263441.11
ENST00000395325.7
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr11_+_9384621 0.02 ENST00000379719.8
ENST00000527431.1
ENST00000630083.1
IPO7
importin 7
chr4_-_152536045 0.02 ENST00000603548.6
ENST00000281708.10
FBXW7
F-box and WD repeat domain containing 7
chr4_-_110636963 0.01 ENST00000394595.8
PITX2
paired like homeodomain 2
chr6_-_13711817 0.01 ENST00000011619.6
RANBP9
RAN binding protein 9
chr15_-_61229297 0.01 ENST00000335670.11
RORA
RAR related orphan receptor A
chr12_+_112418928 0.01 ENST00000351677.7
ENST00000639857.1
PTPN11
protein tyrosine phosphatase non-receptor type 11
chr18_+_52340179 0.00 ENST00000442544.7
DCC
DCC netrin 1 receptor
chr18_+_65751000 0.00 ENST00000397968.4
CDH7
cadherin 7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.3 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 0.3 GO:1903904 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.0 0.1 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 0.2 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 0.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.0 0.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:2001184 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.4 GO:0070601 N-terminal protein amino acid acetylation(GO:0006474) centromeric sister chromatid cohesion(GO:0070601)
0.0 0.1 GO:0035801 adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.2 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:1904908 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.7 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0032279 axonemal microtubule(GO:0005879) asymmetric synapse(GO:0032279)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.0 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.0 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.8 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones