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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UGACCUA

Z-value: 0.52

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miRNA associated with seed UGACCUA

NamemiRBASE accession
hsa-miR-192-5p
MIMAT0000222
hsa-miR-215-5p
MIMAT0000272

Activity profile of UGACCUA motif

Sorted Z-values of UGACCUA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UGACCUA

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_120604084 0.87 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chrX_+_65667645 0.67 ENST00000360270.7
MSN
moesin
chr3_+_172040554 0.65 ENST00000336824.8
ENST00000423424.5
FNDC3B
fibronectin type III domain containing 3B
chr1_+_62437015 0.65 ENST00000339950.5
USP1
ubiquitin specific peptidase 1
chr15_-_34101807 0.61 ENST00000527822.5
ENST00000528949.1
ENST00000256545.9
EMC7
ER membrane protein complex subunit 7
chr8_+_48008409 0.56 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2
chr3_+_105366877 0.49 ENST00000306107.9
ALCAM
activated leukocyte cell adhesion molecule
chr16_+_53703963 0.45 ENST00000636218.1
ENST00000637001.1
ENST00000471389.6
ENST00000637969.1
ENST00000640179.1
FTO
FTO alpha-ketoglutarate dependent dioxygenase
chr8_+_60678705 0.40 ENST00000423902.7
CHD7
chromodomain helicase DNA binding protein 7
chr6_+_146543824 0.39 ENST00000367495.4
RAB32
RAB32, member RAS oncogene family
chr1_-_9823953 0.37 ENST00000377298.9
ENST00000361311.4
CLSTN1
calsyntenin 1
chr2_+_108588453 0.37 ENST00000393310.5
LIMS1
LIM zinc finger domain containing 1
chr1_+_179293760 0.34 ENST00000367619.8
SOAT1
sterol O-acyltransferase 1
chr2_-_25878445 0.33 ENST00000336112.9
ENST00000435504.9
ASXL2
ASXL transcriptional regulator 2
chr20_-_37527723 0.31 ENST00000397135.1
ENST00000397137.5
BLCAP
BLCAP apoptosis inducing factor
chr14_+_57268963 0.30 ENST00000261558.8
AP5M1
adaptor related protein complex 5 subunit mu 1
chr22_-_50307598 0.30 ENST00000425954.1
ENST00000449103.5
ENST00000359337.9
PLXNB2
plexin B2
chr10_-_77926724 0.29 ENST00000372391.7
DLG5
discs large MAGUK scaffold protein 5
chr19_-_49072699 0.27 ENST00000221444.2
KCNA7
potassium voltage-gated channel subfamily A member 7
chr3_-_31981228 0.27 ENST00000396556.7
ENST00000438237.6
OSBPL10
oxysterol binding protein like 10
chr1_+_181088692 0.27 ENST00000367577.7
IER5
immediate early response 5
chr10_+_68901258 0.27 ENST00000373585.8
DDX50
DExD-box helicase 50
chr9_+_134641768 0.27 ENST00000371817.8
ENST00000618395.4
COL5A1
collagen type V alpha 1 chain
chr3_-_123884290 0.26 ENST00000346322.9
ENST00000360772.7
ENST00000360304.8
MYLK
myosin light chain kinase
chr18_-_36129305 0.25 ENST00000269187.10
ENST00000590986.5
ENST00000440549.6
SLC39A6
solute carrier family 39 member 6
chr17_+_40287861 0.24 ENST00000209728.9
ENST00000580824.5
ENST00000577249.1
ENST00000649662.1
CDC6
cell division cycle 6
chr8_+_109334317 0.23 ENST00000521662.5
ENST00000520147.5
ENST00000521688.6
ENY2
ENY2 transcription and export complex 2 subunit
chr2_-_234497035 0.23 ENST00000390645.2
ENST00000339728.6
ARL4C
ADP ribosylation factor like GTPase 4C
chr11_+_35662739 0.22 ENST00000299413.7
TRIM44
tripartite motif containing 44
chr3_-_160565560 0.22 ENST00000334256.9
ENST00000676866.1
ENST00000469804.1
KPNA4
karyopherin subunit alpha 4
chr1_+_150149819 0.20 ENST00000369124.5
PLEKHO1
pleckstrin homology domain containing O1
chr8_+_42152946 0.18 ENST00000518421.5
ENST00000174653.3
ENST00000396926.8
ENST00000521280.5
ENST00000522288.5
AP3M2
adaptor related protein complex 3 subunit mu 2
chrX_+_23334841 0.18 ENST00000379361.5
PTCHD1
patched domain containing 1
chr5_-_74640719 0.16 ENST00000302351.9
ENST00000509127.2
ENC1
ectodermal-neural cortex 1
chr3_-_113746218 0.16 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
NAA50
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr16_+_67562514 0.15 ENST00000264010.10
ENST00000401394.6
ENST00000646771.1
CTCF
CCCTC-binding factor
chr1_+_84078043 0.15 ENST00000370689.6
ENST00000370688.7
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr4_+_183099244 0.14 ENST00000403733.8
WWC2
WW and C2 domain containing 2
chr3_-_115071333 0.14 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_42804451 0.14 ENST00000418900.6
ENST00000321331.12
ENST00000430190.5
ENST00000648550.1
HIGD1A
ENSG00000280571.2
HIG1 hypoxia inducible domain family member 1A
novel protein
chr17_-_35089212 0.13 ENST00000584655.5
ENST00000447669.6
ENST00000315249.11
RFFL
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr1_+_101237009 0.12 ENST00000305352.7
S1PR1
sphingosine-1-phosphate receptor 1
chr14_+_100239121 0.11 ENST00000262238.10
YY1
YY1 transcription factor
chr9_+_12693327 0.10 ENST00000388918.10
TYRP1
tyrosinase related protein 1
chr1_+_43979179 0.10 ENST00000434555.7
ENST00000372324.6
ENST00000481924.2
B4GALT2
beta-1,4-galactosyltransferase 2
chr16_-_73048104 0.10 ENST00000268489.10
ZFHX3
zinc finger homeobox 3
chr17_-_4940023 0.09 ENST00000225665.12
ENST00000544061.6
SLC25A11
solute carrier family 25 member 11
chr1_+_179882275 0.09 ENST00000606911.7
ENST00000271583.7
TOR1AIP1
torsin 1A interacting protein 1
chr15_+_89088417 0.08 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
ABHD2
abhydrolase domain containing 2, acylglycerol lipase
chr18_+_56651335 0.06 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chr22_-_21867610 0.06 ENST00000215832.11
ENST00000398822.7
MAPK1
mitogen-activated protein kinase 1
chr2_+_26692686 0.06 ENST00000620977.1
ENST00000302909.4
KCNK3
potassium two pore domain channel subfamily K member 3
chr17_+_2796404 0.05 ENST00000366401.8
ENST00000254695.13
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr17_-_58517835 0.05 ENST00000579921.1
ENST00000579925.5
ENST00000323456.9
MTMR4
myotubularin related protein 4
chr3_+_11272413 0.05 ENST00000446450.6
ENST00000354956.9
ENST00000354449.7
ENST00000419112.5
ATG7
autophagy related 7
chr12_+_752551 0.05 ENST00000315939.11
ENST00000340908.9
ENST00000535572.5
WNK1
WNK lysine deficient protein kinase 1
chr7_-_139109702 0.04 ENST00000471652.1
ENST00000242351.10
ZC3HAV1
zinc finger CCCH-type containing, antiviral 1
chr6_-_116060859 0.04 ENST00000606080.2
FRK
fyn related Src family tyrosine kinase
chr7_+_77798750 0.03 ENST00000416283.6
ENST00000422959.6
ENST00000307305.12
ENST00000424760.5
PHTF2
putative homeodomain transcription factor 2
chr20_-_59940289 0.00 ENST00000370996.5
PPP1R3D
protein phosphatase 1 regulatory subunit 3D
chr1_-_9910169 0.00 ENST00000377263.6
CTNNBIP1
catenin beta interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.4 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.1 0.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.7 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.3 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.4 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.2 GO:1904116 traversing start control point of mitotic cell cycle(GO:0007089) response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.1 0.3 GO:2000542 negative regulation of gastrulation(GO:2000542)
0.0 0.3 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.7 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.3 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.2 GO:0051451 myoblast migration(GO:0051451)
0.0 0.6 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0044805 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.5 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.3 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.3 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.0 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 0.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.2 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.6 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.7 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.3 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.2 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 0.1 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0046625 sphingolipid binding(GO:0046625)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.7 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions