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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UGCAGUC

Z-value: 0.81

Motif logo

logo of

miRNA associated with seed UGCAGUC

NamemiRBASE accession
hsa-miR-455-3p.2

Activity profile of UGCAGUC motif

Sorted Z-values of UGCAGUC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UGCAGUC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_17541157 5.67 ENST00000406397.1
VSNL1
visinin like 1
chr2_+_148875214 4.27 ENST00000435030.6
ENST00000677891.1
ENST00000677843.1
ENST00000678056.1
ENST00000677280.1
KIF5C
kinesin family member 5C
chr6_-_46325641 3.82 ENST00000330430.10
ENST00000405162.2
RCAN2
regulator of calcineurin 2
chr14_+_99684283 3.69 ENST00000261835.8
CYP46A1
cytochrome P450 family 46 subfamily A member 1
chr14_+_92923143 2.96 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr11_-_134411854 2.94 ENST00000392580.5
B3GAT1
beta-1,3-glucuronyltransferase 1
chr12_-_16608183 2.80 ENST00000354662.5
ENST00000538051.5
LMO3
LIM domain only 3
chr2_-_2331225 2.51 ENST00000648627.1
ENST00000649663.1
ENST00000650560.1
ENST00000428368.7
ENST00000648316.1
ENST00000648665.1
ENST00000649313.1
ENST00000399161.7
ENST00000647738.2
MYT1L
myelin transcription factor 1 like
chr17_-_80476597 2.38 ENST00000306773.5
NPTX1
neuronal pentraxin 1
chr12_-_106138946 2.09 ENST00000261402.7
NUAK1
NUAK family kinase 1
chr10_-_60389833 2.06 ENST00000280772.7
ANK3
ankyrin 3
chr7_-_44325617 1.58 ENST00000358707.7
ENST00000457475.5
CAMK2B
calcium/calmodulin dependent protein kinase II beta
chr11_-_132943671 1.51 ENST00000331898.11
OPCML
opioid binding protein/cell adhesion molecule like
chr6_+_142147162 1.43 ENST00000452973.6
ENST00000620996.4
ENST00000367621.1
ENST00000367630.9
VTA1
vesicle trafficking 1
chr3_-_18425295 1.40 ENST00000338745.11
ENST00000450898.1
SATB1
SATB homeobox 1
chr5_+_153490655 1.34 ENST00000518142.5
ENST00000285900.10
GRIA1
glutamate ionotropic receptor AMPA type subunit 1
chr8_-_65842051 1.23 ENST00000401827.8
PDE7A
phosphodiesterase 7A
chr9_-_129028277 1.22 ENST00000372554.8
ENST00000372564.8
SH3GLB2
SH3 domain containing GRB2 like, endophilin B2
chr2_-_168247569 1.20 ENST00000355999.5
STK39
serine/threonine kinase 39
chr7_+_94509793 1.05 ENST00000297273.9
CASD1
CAS1 domain containing 1
chr1_+_87328860 0.98 ENST00000370544.10
LMO4
LIM domain only 4
chr16_-_4847265 0.97 ENST00000591451.5
ENST00000436648.9
ENST00000321919.14
ENST00000588297.5
GLYR1
glyoxylate reductase 1 homolog
chr2_-_11344580 0.96 ENST00000616279.4
ENST00000315872.11
ROCK2
Rho associated coiled-coil containing protein kinase 2
chr19_-_12723925 0.95 ENST00000425528.6
ENST00000589337.5
ENST00000588216.5
TNPO2
transportin 2
chr1_+_244051275 0.88 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr16_+_50548387 0.87 ENST00000268459.6
NKD1
NKD inhibitor of WNT signaling pathway 1
chrX_-_54357993 0.85 ENST00000375169.7
ENST00000354646.6
WNK3
WNK lysine deficient protein kinase 3
chr2_-_69643703 0.83 ENST00000406297.7
ENST00000409085.9
AAK1
AP2 associated kinase 1
chr11_+_33257265 0.74 ENST00000303296.9
ENST00000379016.7
HIPK3
homeodomain interacting protein kinase 3
chr4_-_42657085 0.70 ENST00000264449.14
ENST00000510289.1
ENST00000381668.9
ATP8A1
ATPase phospholipid transporting 8A1
chr3_-_38816217 0.67 ENST00000449082.3
ENST00000655275.1
SCN10A
sodium voltage-gated channel alpha subunit 10
chr16_-_66751591 0.66 ENST00000440564.6
ENST00000443351.6
ENST00000566150.5
ENST00000258198.7
DYNC1LI2
dynein cytoplasmic 1 light intermediate chain 2
chr3_-_53846374 0.66 ENST00000315251.11
CHDH
choline dehydrogenase
chr12_+_752551 0.64 ENST00000315939.11
ENST00000340908.9
ENST00000535572.5
WNK1
WNK lysine deficient protein kinase 1
chr15_+_33310946 0.62 ENST00000415757.7
ENST00000634891.2
ENST00000389232.9
ENST00000622037.1
RYR3
ryanodine receptor 3
chr12_+_110468803 0.61 ENST00000377673.10
FAM216A
family with sequence similarity 216 member A
chr2_-_148020689 0.60 ENST00000457954.5
ENST00000392857.10
ENST00000540442.5
ENST00000535373.5
ORC4
origin recognition complex subunit 4
chr11_-_70661762 0.60 ENST00000357171.7
ENST00000412252.5
ENST00000449833.6
ENST00000338508.8
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr11_+_26332117 0.60 ENST00000531646.1
ENST00000256737.8
ANO3
anoctamin 3
chr1_-_115338231 0.59 ENST00000369512.3
ENST00000680116.1
ENST00000681124.1
ENST00000675637.2
ENST00000676038.2
NGF
nerve growth factor
chr12_-_53499615 0.58 ENST00000267079.6
MAP3K12
mitogen-activated protein kinase kinase kinase 12
chr1_+_232950580 0.57 ENST00000366628.10
ENST00000366627.4
NTPCR
nucleoside-triphosphatase, cancer-related
chr3_+_94062974 0.56 ENST00000314622.9
NSUN3
NOP2/Sun RNA methyltransferase 3
chr2_+_118088432 0.54 ENST00000245787.9
INSIG2
insulin induced gene 2
chr11_-_73761051 0.53 ENST00000336083.8
ENST00000536566.5
ENST00000541588.5
ENST00000540771.5
ENST00000310653.10
RAB6A
RAB6A, member RAS oncogene family
chr17_-_44503369 0.52 ENST00000585614.1
ENST00000591680.6
GPATCH8
G-patch domain containing 8
chr3_-_165196369 0.52 ENST00000475390.2
SLITRK3
SLIT and NTRK like family member 3
chr19_-_3700390 0.51 ENST00000679885.1
ENST00000537021.1
ENST00000589578.5
ENST00000539785.5
ENST00000335312.8
PIP5K1C
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
chr1_+_21509415 0.50 ENST00000374840.8
ENST00000539907.5
ENST00000540617.5
ALPL
alkaline phosphatase, biomineralization associated
chr1_-_56579555 0.49 ENST00000371250.4
PLPP3
phospholipid phosphatase 3
chr10_-_118754956 0.49 ENST00000369151.8
CACUL1
CDK2 associated cullin domain 1
chr2_-_153478753 0.46 ENST00000325926.4
RPRM
reprimo, TP53 dependent G2 arrest mediator homolog
chr10_-_47523638 0.46 ENST00000452145.6
AGAP9
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
chr1_+_11691688 0.45 ENST00000294485.6
DRAXIN
dorsal inhibitory axon guidance protein
chr17_-_63700100 0.44 ENST00000578993.5
ENST00000259006.8
ENST00000583211.5
LIMD2
LIM domain containing 2
chr2_+_165469647 0.43 ENST00000421875.5
ENST00000314499.11
ENST00000409664.5
ENST00000651982.1
CSRNP3
cysteine and serine rich nuclear protein 3
chr6_-_16761447 0.41 ENST00000244769.8
ENST00000436367.6
ATXN1
ataxin 1
chr7_+_102285125 0.41 ENST00000536178.3
SH2B2
SH2B adaptor protein 2
chr1_-_21050952 0.40 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr15_-_42457513 0.39 ENST00000565611.5
ENST00000263805.8
ZNF106
zinc finger protein 106
chr3_-_12158901 0.38 ENST00000287814.5
TIMP4
TIMP metallopeptidase inhibitor 4
chr1_+_237042176 0.38 ENST00000366574.7
RYR2
ryanodine receptor 2
chr3_-_15065240 0.37 ENST00000449354.6
ENST00000253686.7
ENST00000444840.6
MRPS25
mitochondrial ribosomal protein S25
chr3_-_129688691 0.36 ENST00000432054.6
TMCC1
transmembrane and coiled-coil domain family 1
chr14_+_102777461 0.36 ENST00000560371.5
ENST00000347662.8
TRAF3
TNF receptor associated factor 3
chr5_+_149730260 0.35 ENST00000360453.8
ENST00000394320.7
ENST00000309241.10
PPARGC1B
PPARG coactivator 1 beta
chr1_+_27725945 0.35 ENST00000373954.11
ENST00000419687.6
FAM76A
family with sequence similarity 76 member A
chr5_-_32444722 0.35 ENST00000265069.13
ZFR
zinc finger RNA binding protein
chr10_-_73495966 0.33 ENST00000342558.3
ENST00000360663.10
ENST00000394828.6
ENST00000394829.6
PPP3CB
protein phosphatase 3 catalytic subunit beta
chr15_-_34336749 0.33 ENST00000397707.6
ENST00000560611.5
SLC12A6
solute carrier family 12 member 6
chr4_+_169620527 0.32 ENST00000360642.7
ENST00000512813.5
ENST00000513761.6
CLCN3
chloride voltage-gated channel 3
chr15_+_48878070 0.31 ENST00000530028.3
ENST00000560490.1
EID1
EP300 interacting inhibitor of differentiation 1
chr3_-_123585013 0.30 ENST00000383657.10
HACD2
3-hydroxyacyl-CoA dehydratase 2
chr5_-_134226059 0.29 ENST00000519718.1
ENST00000481195.6
ENSG00000272772.1
PPP2CA
novel protein
protein phosphatase 2 catalytic subunit alpha
chr14_+_70641896 0.29 ENST00000256367.3
TTC9
tetratricopeptide repeat domain 9
chr5_+_175796310 0.27 ENST00000359546.8
CPLX2
complexin 2
chr20_+_3471003 0.26 ENST00000262919.10
ENST00000446916.2
ATRN
attractin
chr3_+_122184233 0.23 ENST00000638421.1
ENST00000498619.4
CASR
calcium sensing receptor
chr12_+_120496101 0.22 ENST00000550178.1
ENST00000550845.5
ENST00000549989.1
ENST00000552870.1
ENST00000242577.11
DYNLL1
dynein light chain LC8-type 1
chr10_-_102502669 0.20 ENST00000487599.1
ACTR1A
actin related protein 1A
chr4_-_98929092 0.19 ENST00000280892.10
ENST00000511644.5
ENST00000504432.5
ENST00000450253.7
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr14_+_56579782 0.19 ENST00000261556.11
ENST00000538838.5
TMEM260
transmembrane protein 260
chr16_-_56425424 0.18 ENST00000290649.10
AMFR
autocrine motility factor receptor
chr1_-_23344314 0.16 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr15_+_100602519 0.15 ENST00000332783.12
ENST00000558747.5
ENST00000343276.4
ASB7
ankyrin repeat and SOCS box containing 7
chr10_-_103855406 0.15 ENST00000355946.6
ENST00000369774.8
SH3PXD2A
SH3 and PX domains 2A
chrX_-_110795765 0.15 ENST00000372045.5
ENST00000394797.8
ENST00000372042.6
ENST00000482160.5
ENST00000444321.2
CHRDL1
chordin like 1
chr6_-_30617232 0.14 ENST00000376511.7
PPP1R10
protein phosphatase 1 regulatory subunit 10
chr9_+_122264857 0.14 ENST00000344641.8
ENST00000441707.5
ENST00000373723.9
ENST00000373729.5
MRRF
mitochondrial ribosome recycling factor
chr20_-_14337602 0.14 ENST00000378053.3
ENST00000341420.5
FLRT3
fibronectin leucine rich transmembrane protein 3
chr15_-_74433942 0.13 ENST00000543145.6
ENST00000261918.9
SEMA7A
semaphorin 7A (John Milton Hagen blood group)
chr2_-_53859929 0.12 ENST00000394705.3
ENST00000406625.6
GPR75
ASB3
G protein-coupled receptor 75
ankyrin repeat and SOCS box containing 3
chrX_-_111270474 0.11 ENST00000324068.2
CAPN6
calpain 6
chr7_-_32891744 0.09 ENST00000304056.9
KBTBD2
kelch repeat and BTB domain containing 2
chr3_+_138187248 0.09 ENST00000538260.5
ENST00000481646.5
ENST00000491704.5
ENST00000469044.6
ENST00000461600.5
ENST00000466749.5
ENST00000358441.6
ENST00000489213.5
ARMC8
armadillo repeat containing 8
chr12_-_48004467 0.08 ENST00000380518.8
COL2A1
collagen type II alpha 1 chain
chr11_-_86955385 0.07 ENST00000531380.2
FZD4
frizzled class receptor 4
chr4_-_72569204 0.07 ENST00000286657.10
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif 3
chr20_+_58309704 0.06 ENST00000244040.4
RAB22A
RAB22A, member RAS oncogene family
chrX_+_108439866 0.06 ENST00000361603.7
COL4A5
collagen type IV alpha 5 chain
chr19_+_35269065 0.05 ENST00000595068.5
ENST00000379134.7
ENST00000594064.5
ENST00000598058.1
USF2
upstream transcription factor 2, c-fos interacting
chr10_+_96832252 0.05 ENST00000676187.1
ENST00000675687.1
ENST00000676123.1
ENST00000675471.1
ENST00000371103.8
ENST00000421806.4
ENST00000675250.1
ENST00000540664.6
ENST00000676414.1
LCOR
ligand dependent nuclear receptor corepressor
chr14_+_94026314 0.05 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr17_-_39864304 0.03 ENST00000346872.8
IKZF3
IKAROS family zinc finger 3
chr1_-_77979054 0.03 ENST00000370768.7
ENST00000370767.5
ENST00000421641.1
FUBP1
far upstream element binding protein 1
chr5_+_128083757 0.02 ENST00000262461.7
ENST00000628403.2
ENST00000343225.4
SLC12A2
solute carrier family 12 member 2
chr9_-_120793377 0.02 ENST00000684001.1
ENST00000684405.1
ENST00000608872.6
FBXW2
F-box and WD repeat domain containing 2
chr6_+_98834560 0.01 ENST00000328345.8
POU3F2
POU class 3 homeobox 2
chr17_+_68512379 0.01 ENST00000392711.5
ENST00000585427.5
ENST00000589228.6
ENST00000536854.6
ENST00000588702.5
ENST00000589309.5
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr1_-_179229671 0.01 ENST00000502732.6
ENST00000392043.4
ABL2
ABL proto-oncogene 2, non-receptor tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
0.5 2.1 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5 2.1 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.4 2.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.3 3.1 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.3 3.7 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.3 0.9 GO:0007525 somatic muscle development(GO:0007525)
0.2 2.4 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.2 0.7 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.2 0.6 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.2 0.6 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.2 0.6 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.2 0.5 GO:0071529 cementum mineralization(GO:0071529)
0.1 1.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 6.0 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.1 0.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 4.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 1.4 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 0.7 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.6 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 1.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.7 GO:0086043 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.1 0.4 GO:0098904 regulation of AV node cell action potential(GO:0098904)
0.1 0.6 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 1.0 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 1.6 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 0.3 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 3.8 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 0.6 GO:0032455 nerve growth factor processing(GO:0032455)
0.1 2.5 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 2.6 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1 1.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.5 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 0.5 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 0.2 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.3 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.5 GO:0008354 germ cell migration(GO:0008354)
0.0 0.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.7 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 1.4 GO:0008038 neuron recognition(GO:0008038)
0.0 0.8 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.2 GO:2000580 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.3 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0 0.7 GO:0051642 centrosome localization(GO:0051642)
0.0 0.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.1 GO:0019086 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086)
0.0 0.6 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0003344 pericardium morphogenesis(GO:0003344)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.3 GO:0035253 ciliary rootlet(GO:0035253)
0.3 1.3 GO:0044308 axonal spine(GO:0044308)
0.2 3.7 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.4 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 2.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731) axon initial segment(GO:0043194)
0.1 0.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.7 GO:0071439 clathrin complex(GO:0071439)
0.1 0.6 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 2.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0005883 neurofilament(GO:0005883)
0.0 1.4 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 2.0 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.4 3.8 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 1.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 1.0 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.2 0.6 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.2 1.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 4.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.6 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.1 0.5 GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 1.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.6 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 3.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.3 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
0.1 1.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.5 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.4 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.6 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.9 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 0.6 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.1 2.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 1.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins