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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UGUGCUU
Z-value: 3.49
Motif logo
miRNA associated with seed UGUGCUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-218-5p
|
MIMAT0000275 |
Activity profile of UGUGCUU motif
Sorted Z-values of UGUGCUU motif
Network of associatons between targets according to the STRING database.
First level regulatory network of UGUGCUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 33.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 9.5 | 28.5 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 6.3 | 25.1 | GO:1903294 | regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296) |
| 6.2 | 18.5 | GO:0099526 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 5.0 | 19.8 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 4.7 | 14.0 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 4.2 | 12.6 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 3.9 | 27.6 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 3.9 | 15.6 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 3.4 | 10.2 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 3.1 | 15.7 | GO:1902612 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 2.9 | 8.7 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 2.7 | 8.2 | GO:0019075 | virus maturation(GO:0019075) |
| 2.6 | 21.0 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 2.6 | 28.1 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 2.4 | 7.1 | GO:0015670 | carbon dioxide transport(GO:0015670) dipeptide transport(GO:0042938) |
| 2.2 | 6.5 | GO:0019046 | release from viral latency(GO:0019046) |
| 2.1 | 6.2 | GO:1904732 | regulation of electron carrier activity(GO:1904732) |
| 1.9 | 17.5 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 1.9 | 5.7 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 1.9 | 9.5 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 1.9 | 3.7 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 1.8 | 31.0 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 1.8 | 16.1 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 1.8 | 23.1 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 1.8 | 10.5 | GO:0048840 | otolith development(GO:0048840) |
| 1.7 | 5.2 | GO:0038162 | erythropoietin-mediated signaling pathway(GO:0038162) mast cell proliferation(GO:0070662) |
| 1.7 | 27.3 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 1.6 | 6.5 | GO:0019470 | 4-hydroxyproline catabolic process(GO:0019470) |
| 1.5 | 61.4 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 1.4 | 4.2 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 1.4 | 26.5 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 1.4 | 6.9 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
| 1.4 | 8.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.3 | 7.8 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 1.3 | 16.6 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 1.3 | 5.1 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 1.2 | 3.7 | GO:2000850 | negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 1.2 | 3.6 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 1.2 | 3.6 | GO:1900155 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 1.2 | 5.9 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 1.1 | 2.2 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 1.1 | 12.3 | GO:0097106 | postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107) gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 1.1 | 14.3 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 1.1 | 5.4 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 1.0 | 5.2 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 1.0 | 10.0 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 1.0 | 4.9 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 1.0 | 6.9 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 1.0 | 11.6 | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) |
| 0.9 | 15.9 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.9 | 14.9 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.9 | 7.3 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.9 | 9.8 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.9 | 38.8 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.8 | 17.3 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.8 | 21.7 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.8 | 30.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.8 | 16.2 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.8 | 3.1 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 0.8 | 4.5 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.7 | 6.7 | GO:2000582 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.7 | 9.6 | GO:0042354 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.7 | 23.5 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.7 | 1.4 | GO:0021836 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.7 | 2.1 | GO:0051228 | mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) |
| 0.7 | 1.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.7 | 7.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.7 | 6.5 | GO:0098908 | regulation of neuronal action potential(GO:0098908) |
| 0.7 | 23.5 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.6 | 3.9 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.6 | 1.9 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 0.6 | 7.6 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.6 | 30.1 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.6 | 23.4 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.6 | 3.1 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.6 | 29.1 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.6 | 4.8 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.6 | 5.4 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.6 | 2.4 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.6 | 4.2 | GO:0006655 | phosphatidylglycerol biosynthetic process(GO:0006655) |
| 0.6 | 8.9 | GO:0070102 | interleukin-6-mediated signaling pathway(GO:0070102) |
| 0.6 | 16.4 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.6 | 14.1 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
| 0.6 | 5.1 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.5 | 9.9 | GO:0048490 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.5 | 1.6 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.5 | 7.3 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.5 | 1.5 | GO:1900114 | positive regulation of histone H3-K9 trimethylation(GO:1900114) |
| 0.5 | 26.7 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.5 | 4.4 | GO:0006682 | protein localization to paranode region of axon(GO:0002175) galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.5 | 2.4 | GO:0034091 | regulation of maintenance of sister chromatid cohesion(GO:0034091) regulation of maintenance of mitotic sister chromatid cohesion(GO:0034182) |
| 0.5 | 7.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.5 | 77.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 1.4 | GO:0072023 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 0.5 | 21.1 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.4 | 24.7 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.4 | 2.2 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.4 | 10.4 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.4 | 5.9 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.4 | 17.4 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.4 | 1.2 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.4 | 12.7 | GO:0014072 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.4 | 2.7 | GO:0090650 | response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.4 | 4.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.4 | 4.5 | GO:0031034 | myosin filament assembly(GO:0031034) |
| 0.4 | 6.7 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.4 | 6.1 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.4 | 23.3 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.3 | 1.0 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.3 | 9.7 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.3 | 2.7 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.3 | 13.5 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.3 | 9.4 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process(GO:0015012) |
| 0.3 | 4.5 | GO:0030166 | proteoglycan biosynthetic process(GO:0030166) |
| 0.3 | 8.7 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.3 | 3.9 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.3 | 1.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.3 | 23.8 | GO:0007422 | peripheral nervous system development(GO:0007422) |
| 0.2 | 11.6 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.2 | 6.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.2 | 3.5 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.2 | 2.3 | GO:1902525 | regulation of protein monoubiquitination(GO:1902525) |
| 0.2 | 4.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.2 | 3.5 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.2 | 2.7 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.2 | 7.7 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.2 | 2.0 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.2 | 2.4 | GO:2000505 | regulation of energy homeostasis(GO:2000505) |
| 0.2 | 5.6 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.2 | 1.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.2 | 0.5 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.2 | 3.6 | GO:0006688 | glycosphingolipid biosynthetic process(GO:0006688) |
| 0.2 | 2.4 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.2 | 8.2 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.2 | 2.1 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.2 | 12.2 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.2 | 4.7 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.2 | 1.8 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.1 | 1.3 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.1 | 7.1 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 0.4 | GO:0060029 | convergent extension involved in organogenesis(GO:0060029) |
| 0.1 | 0.3 | GO:0061739 | protein lipidation involved in autophagosome assembly(GO:0061739) |
| 0.1 | 3.1 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.1 | 14.6 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.1 | 0.9 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 16.8 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.1 | 13.8 | GO:0008286 | insulin receptor signaling pathway(GO:0008286) |
| 0.1 | 2.6 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.1 | 1.4 | GO:0021794 | thalamus development(GO:0021794) |
| 0.1 | 7.6 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.1 | 3.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 1.0 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.1 | 1.2 | GO:0045199 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 9.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.1 | 3.4 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 0.8 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 2.1 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.1 | 5.7 | GO:0006023 | aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024) |
| 0.1 | 0.6 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.1 | 0.9 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 4.2 | GO:0035690 | cellular response to drug(GO:0035690) |
| 0.1 | 14.3 | GO:0043406 | positive regulation of MAP kinase activity(GO:0043406) |
| 0.1 | 2.6 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 0.5 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 0.7 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
| 0.0 | 0.3 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 3.7 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 1.9 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 1.9 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.4 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.0 | 0.7 | GO:2000352 | negative regulation of endothelial cell apoptotic process(GO:2000352) |
| 0.0 | 4.0 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 1.1 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 2.5 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 1.6 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 0.0 | 5.1 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 2.2 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 0.5 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.0 | 0.3 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 0.7 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.9 | GO:0007004 | telomere maintenance via telomerase(GO:0007004) |
| 0.0 | 0.2 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 36.2 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 6.7 | 33.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 6.2 | 18.5 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569) |
| 3.5 | 14.1 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 3.3 | 20.0 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 1.8 | 7.3 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 1.5 | 7.7 | GO:0044305 | calyx of Held(GO:0044305) |
| 1.4 | 8.7 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 1.4 | 19.8 | GO:0043083 | synaptic cleft(GO:0043083) |
| 1.4 | 4.2 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 1.3 | 58.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 1.1 | 13.8 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.9 | 8.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.9 | 15.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.8 | 5.9 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.8 | 13.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.8 | 7.3 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.8 | 3.1 | GO:0002945 | cyclin K-CDK13 complex(GO:0002945) |
| 0.7 | 8.9 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.7 | 11.7 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.6 | 3.1 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.6 | 3.8 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.6 | 5.6 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.6 | 45.0 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.6 | 39.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.5 | 50.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.5 | 5.7 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.5 | 9.7 | GO:0016342 | catenin complex(GO:0016342) |
| 0.5 | 8.1 | GO:0005883 | neurofilament(GO:0005883) |
| 0.5 | 14.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.5 | 6.5 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.5 | 1.4 | GO:1990597 | AIP1-IRE1 complex(GO:1990597) |
| 0.4 | 20.6 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.4 | 8.3 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.4 | 2.4 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.4 | 8.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.4 | 59.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.4 | 20.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 4.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.3 | 1.3 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.3 | 2.7 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.3 | 27.7 | GO:0016234 | inclusion body(GO:0016234) |
| 0.3 | 6.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.3 | 6.1 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.2 | 2.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 3.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.2 | 9.9 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.2 | 69.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 25.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.2 | 23.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 17.1 | GO:0098793 | presynapse(GO:0098793) |
| 0.2 | 2.1 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.2 | 1.6 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.2 | 5.5 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.2 | 13.5 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.1 | 5.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 1.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 1.1 | GO:0031371 | ubiquitin conjugating enzyme complex(GO:0031371) |
| 0.1 | 2.1 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 1.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 53.3 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 14.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 9.4 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 4.1 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 29.6 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 32.9 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 16.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 6.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 85.6 | GO:0044431 | Golgi apparatus part(GO:0044431) |
| 0.1 | 2.0 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 1.3 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 6.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 5.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 11.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 1.9 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 104.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 5.0 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.7 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 2.4 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 15.0 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.1 | 2.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 2.2 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.0 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 5.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 3.9 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.0 | 0.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 6.5 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 2.5 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.3 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 1.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 3.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 3.6 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 4.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.2 | 33.0 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 6.7 | 33.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 6.2 | 18.5 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 4.5 | 36.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 4.3 | 17.2 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 3.6 | 28.5 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 3.5 | 14.0 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 2.6 | 15.6 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 2.5 | 22.9 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 2.5 | 7.6 | GO:0001601 | peptide YY receptor activity(GO:0001601) |
| 2.4 | 12.0 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 2.2 | 6.5 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 2.1 | 32.1 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577) |
| 1.9 | 29.1 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 1.9 | 7.5 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 1.7 | 13.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 1.7 | 5.1 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 1.6 | 31.3 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 1.5 | 4.5 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 1.5 | 4.4 | GO:0086059 | voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059) |
| 1.4 | 4.2 | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 1.4 | 8.2 | GO:0016807 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 1.4 | 5.4 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 1.2 | 25.8 | GO:0043274 | phospholipase binding(GO:0043274) |
| 1.2 | 4.9 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 1.2 | 17.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 1.2 | 4.8 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 1.2 | 7.1 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 1.2 | 8.1 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 1.1 | 9.6 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 1.0 | 4.2 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 1.0 | 5.1 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 1.0 | 5.1 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.9 | 2.7 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.9 | 12.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.9 | 7.2 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.9 | 2.7 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.8 | 6.5 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.8 | 7.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.8 | 22.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.8 | 7.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.8 | 3.8 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.7 | 19.3 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.7 | 17.2 | GO:0051430 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.7 | 7.1 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.7 | 19.9 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.7 | 2.0 | GO:0005128 | erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135) |
| 0.7 | 2.7 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.7 | 15.8 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.6 | 3.9 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.6 | 3.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.6 | 22.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.6 | 1.8 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.6 | 4.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.6 | 2.2 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.6 | 9.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.5 | 24.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.5 | 19.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.5 | 8.8 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.5 | 3.6 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.5 | 12.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.5 | 23.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.5 | 16.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.5 | 1.4 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.5 | 1.4 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.4 | 9.1 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.4 | 3.6 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.4 | 1.2 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 0.4 | 29.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.4 | 25.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.4 | 11.0 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.4 | 1.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.4 | 10.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.4 | 6.1 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.3 | 7.9 | GO:0031005 | filamin binding(GO:0031005) |
| 0.3 | 2.6 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.3 | 33.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 2.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.3 | 11.0 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.3 | 5.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.3 | 1.3 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.3 | 15.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.3 | 6.6 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.2 | 3.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.2 | 4.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 33.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 36.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 65.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 3.6 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.2 | 0.5 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 1.5 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.2 | 0.8 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.2 | 4.5 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.2 | 0.8 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.2 | 0.9 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.2 | 4.5 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 3.1 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.2 | 1.8 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 9.6 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 13.0 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.1 | 4.4 | GO:0035250 | UDP-galactosyltransferase activity(GO:0035250) |
| 0.1 | 1.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 3.3 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 77.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 6.6 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 2.6 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 11.4 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 2.9 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 0.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 2.9 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 1.4 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 7.3 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.1 | 2.1 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 5.1 | GO:0016279 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.1 | 1.9 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 2.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.1 | 7.4 | GO:0002039 | p53 binding(GO:0002039) |
| 0.1 | 5.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 1.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 0.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 1.9 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 0.2 | GO:0016426 | tRNA (adenine) methyltransferase activity(GO:0016426) |
| 0.1 | 0.6 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.0 | 2.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.3 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 0.3 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.0 | 0.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 1.1 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 7.0 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 8.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.9 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.2 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 1.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.3 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.5 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 2.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.1 | GO:0015278 | calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604) |
| 0.0 | 0.1 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 70.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.9 | 25.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.7 | 43.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.7 | 39.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.6 | 26.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.5 | 12.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.4 | 17.3 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.4 | 10.3 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.3 | 7.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.3 | 10.5 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 26.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 7.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 3.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 5.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.0 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 3.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 5.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 7.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 7.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 2.0 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 2.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 10.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 1.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 1.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 21.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.8 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 0.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 58.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 1.4 | 36.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 1.3 | 54.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 1.3 | 31.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 1.3 | 28.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 1.0 | 17.2 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.9 | 18.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.9 | 15.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.8 | 32.4 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.8 | 17.0 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.8 | 22.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 13.7 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.5 | 16.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.4 | 7.1 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.4 | 13.7 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.3 | 13.4 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.3 | 6.4 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.3 | 14.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 3.7 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.3 | 9.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 10.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 9.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 4.3 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.2 | 4.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.2 | 4.1 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 7.3 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 2.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 3.1 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 1.7 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 1.7 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 20.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 7.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 16.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 10.9 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 1.9 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 0.5 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 2.0 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 3.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 4.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.9 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.9 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 1.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.1 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 2.9 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 1.6 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.1 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.0 | 0.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.3 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |