Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for UUGGUCC
Z-value: 2.00
Motif logo
miRNA associated with seed UUGGUCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-133a-3p.2
|
MIMAT0000427 |
|
hsa-miR-133b
|
MIMAT0000770 |
Activity profile of UUGGUCC motif
Sorted Z-values of UUGGUCC motif
Network of associatons between targets according to the STRING database.
First level regulatory network of UUGGUCC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 8.4 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 2.1 | 6.4 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 1.3 | 3.9 | GO:0007037 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 1.3 | 3.8 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 1.0 | 4.1 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 1.0 | 2.9 | GO:0021722 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.9 | 3.4 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.7 | 4.0 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 0.6 | 5.6 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
| 0.6 | 2.3 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.5 | 7.4 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.5 | 2.1 | GO:0097676 | histone H3-K36 dimethylation(GO:0097676) |
| 0.5 | 2.6 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.5 | 1.5 | GO:0014813 | skeletal muscle satellite cell commitment(GO:0014813) |
| 0.5 | 7.5 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.4 | 2.9 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.4 | 6.2 | GO:0060137 | maternal process involved in parturition(GO:0060137) |
| 0.4 | 2.0 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.4 | 1.2 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.4 | 6.0 | GO:0070444 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.4 | 3.2 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.4 | 3.2 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.3 | 1.4 | GO:1902617 | response to fluoride(GO:1902617) |
| 0.3 | 3.1 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.3 | 3.4 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.3 | 1.7 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.3 | 1.0 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 0.3 | 1.0 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.3 | 2.3 | GO:0015886 | heme transport(GO:0015886) |
| 0.2 | 2.5 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.2 | 1.5 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.2 | 1.9 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.2 | 1.4 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.2 | 2.1 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.2 | 0.5 | GO:1902722 | positive regulation of prolactin secretion(GO:1902722) |
| 0.2 | 2.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.2 | 6.2 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.2 | 2.4 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.2 | 9.1 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.2 | 1.9 | GO:0043308 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) |
| 0.2 | 1.6 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.2 | 0.6 | GO:0099403 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.2 | 7.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.2 | 2.1 | GO:0021740 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 2.1 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.2 | 8.0 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.2 | 0.5 | GO:0051136 | regulation of NK T cell differentiation(GO:0051136) |
| 0.2 | 3.2 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.2 | 0.9 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.2 | 4.2 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.2 | 0.5 | GO:1900114 | positive regulation of histone H3-K9 trimethylation(GO:1900114) |
| 0.2 | 1.0 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.2 | 2.4 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.2 | 0.7 | GO:1990834 | response to odorant(GO:1990834) |
| 0.2 | 1.3 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.2 | 1.4 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.2 | 0.5 | GO:2000619 | negative regulation of prostaglandin biosynthetic process(GO:0031393) negative regulation of helicase activity(GO:0051097) negative regulation of response to alcohol(GO:1901420) negative regulation of histone H4-K16 acetylation(GO:2000619) |
| 0.1 | 5.4 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 7.9 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.1 | 8.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 1.2 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 2.0 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.1 | 0.8 | GO:0044266 | angiotensin catabolic process in blood(GO:0002005) multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) |
| 0.1 | 7.5 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 4.5 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.1 | 2.9 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.1 | 1.0 | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 0.6 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.1 | 1.2 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 0.6 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.1 | 1.7 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 5.7 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.1 | 0.6 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) |
| 0.1 | 0.7 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.1 | 1.5 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.1 | 4.9 | GO:0090102 | cochlea development(GO:0090102) |
| 0.1 | 1.8 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 2.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 1.5 | GO:0071670 | smooth muscle cell chemotaxis(GO:0071670) |
| 0.1 | 0.3 | GO:0036166 | phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239) |
| 0.1 | 4.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.5 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.1 | 2.4 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.1 | 1.3 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.1 | 2.4 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.1 | 1.5 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.1 | 2.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 3.9 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 0.7 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
| 0.1 | 0.8 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.1 | 5.0 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.1 | 0.8 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.1 | 0.3 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 5.7 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.1 | 1.5 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 0.6 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.7 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.0 | 0.8 | GO:0007614 | short-term memory(GO:0007614) |
| 0.0 | 1.2 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 1.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 0.9 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.7 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.0 | 0.3 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.2 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.0 | 2.7 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 0.3 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) positive regulation of histone H4 acetylation(GO:0090240) |
| 0.0 | 1.6 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 3.1 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.5 | GO:0070072 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.0 | 2.3 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 2.1 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 2.7 | GO:0032760 | positive regulation of tumor necrosis factor production(GO:0032760) |
| 0.0 | 1.3 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.0 | 0.3 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.0 | 0.1 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.0 | 5.0 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 0.1 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.0 | 0.2 | GO:0002001 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) renin secretion into blood stream(GO:0002001) |
| 0.0 | 0.6 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.0 | 0.1 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 0.0 | 0.1 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.0 | 1.8 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 1.5 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.0 | 0.2 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 0.1 | GO:0045144 | meiotic sister chromatid segregation(GO:0045144) |
| 0.0 | 3.1 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.0 | 0.2 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.0 | 1.4 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.7 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 0.2 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.1 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 0.5 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 0.8 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.6 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 1.9 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.6 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.6 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 1.6 | GO:0019233 | sensory perception of pain(GO:0019233) |
| 0.0 | 0.3 | GO:0035584 | calcium-mediated signaling using intracellular calcium source(GO:0035584) regulation of synapse maturation(GO:0090128) positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 1.1 | GO:0048477 | oogenesis(GO:0048477) |
| 0.0 | 0.1 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.0 | 0.4 | GO:0010863 | positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.4 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 1.7 | 8.4 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.1 | 5.4 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.0 | 4.1 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.9 | 2.6 | GO:0044393 | microspike(GO:0044393) |
| 0.7 | 3.7 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.6 | 2.9 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.5 | 1.9 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.4 | 10.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 2.5 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.3 | 3.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 4.1 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 1.5 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.2 | 2.7 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.2 | 1.3 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 0.6 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.2 | 10.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 3.1 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.2 | 3.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 1.9 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 8.0 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 3.9 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 2.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 2.3 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.5 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.1 | 4.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 2.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 1.4 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 3.6 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 0.6 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 2.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 0.5 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.1 | 0.8 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 2.4 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.5 | GO:0032021 | NELF complex(GO:0032021) |
| 0.1 | 4.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 0.1 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
| 0.1 | 1.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 3.4 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 4.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 1.6 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 0.8 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.0 | 0.7 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 2.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.1 | GO:0071920 | cleavage body(GO:0071920) |
| 0.0 | 6.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.6 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 2.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 4.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 4.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.1 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 3.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 3.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.6 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.0 | 0.7 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 16.2 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.5 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.4 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 9.4 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 1.7 | 8.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.6 | 9.4 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 1.0 | 4.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 1.0 | 2.9 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.9 | 7.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.6 | 6.4 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.6 | 5.0 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.5 | 3.8 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.5 | 1.8 | GO:0035473 | lipase binding(GO:0035473) |
| 0.4 | 2.2 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.4 | 2.5 | GO:0070728 | leucine binding(GO:0070728) |
| 0.4 | 2.4 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.4 | 2.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.4 | 2.7 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.3 | 4.0 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.3 | 4.2 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.3 | 1.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.3 | 3.9 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 2.3 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.3 | 4.0 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.3 | 9.0 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.3 | 2.5 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.3 | 3.3 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.2 | 2.1 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.2 | 1.6 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.2 | 1.4 | GO:0004137 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.2 | 0.6 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 3.9 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 6.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 5.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 0.9 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.2 | 5.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 7.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 2.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 0.6 | GO:0070905 | serine binding(GO:0070905) |
| 0.1 | 2.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 2.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 1.4 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 1.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 0.5 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 0.3 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.1 | 0.5 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.3 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.1 | 2.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.1 | 2.1 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.5 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 3.2 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 9.2 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 4.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 0.5 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.1 | 3.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 4.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 2.0 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.8 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.0 | 1.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.6 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.6 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 0.7 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.2 | GO:0097001 | glycolipid transporter activity(GO:0017089) ceramide binding(GO:0097001) |
| 0.0 | 2.1 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 0.3 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.0 | 0.5 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.2 | GO:0016933 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.0 | 6.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.9 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.6 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 1.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 1.5 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.6 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 3.2 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.4 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 2.0 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 3.2 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 3.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.8 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 1.3 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.0 | 0.1 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.0 | 0.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.7 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 3.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.6 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 1.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.4 | GO:0004407 | histone deacetylase activity(GO:0004407) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 11.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 9.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 2.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 1.4 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 2.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 8.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 1.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 2.0 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 2.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 3.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.3 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.3 | 7.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 5.7 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.2 | 4.7 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 8.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 8.5 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 3.9 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.2 | 2.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 2.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 4.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.9 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 3.8 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 2.0 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 2.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 3.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 1.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 1.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 6.7 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 5.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.6 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.5 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 1.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 3.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.3 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.8 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 1.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |