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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UUGUUCG

Z-value: 0.25

Motif logo

logo of

miRNA associated with seed UUGUUCG

NamemiRBASE accession
hsa-miR-375
MIMAT0000728

Activity profile of UUGUUCG motif

Sorted Z-values of UUGUUCG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_+_40443441 3.02 ENST00000269593.5
IGFBP4
insulin like growth factor binding protein 4
chr10_-_125160499 1.28 ENST00000494626.6
ENST00000337195.9
CTBP2
C-terminal binding protein 2
chr3_-_115071333 1.13 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr18_+_22169580 1.09 ENST00000269216.10
GATA6
GATA binding protein 6
chr12_-_76031588 1.06 ENST00000602540.5
PHLDA1
pleckstrin homology like domain family A member 1
chr1_-_225653045 1.03 ENST00000366843.6
ENST00000366844.7
ENAH
ENAH actin regulator
chr2_+_203328378 0.99 ENST00000430418.5
ENST00000261018.12
ENST00000295851.10
ENST00000424558.5
ENST00000417864.5
ENST00000422511.6
ABI2
abl interactor 2
chr11_+_102110437 0.89 ENST00000282441.10
ENST00000526343.5
ENST00000537274.5
ENST00000345877.6
ENST00000615667.4
YAP1
Yes1 associated transcriptional regulator
chr15_+_80779343 0.84 ENST00000220244.7
ENST00000394685.8
ENST00000356249.9
CEMIP
cell migration inducing hyaluronidase 1
chr4_-_156971769 0.84 ENST00000502773.6
PDGFC
platelet derived growth factor C
chr13_+_73058993 0.78 ENST00000377687.6
KLF5
Kruppel like factor 5
chr15_+_56918612 0.78 ENST00000438423.6
ENST00000267811.9
ENST00000333725.10
ENST00000559609.5
TCF12
transcription factor 12
chr5_+_96662214 0.71 ENST00000395812.6
CAST
calpastatin
chr17_+_57085092 0.71 ENST00000575322.1
ENST00000337714.8
AKAP1
A-kinase anchoring protein 1
chr2_+_177392734 0.69 ENST00000680770.1
ENST00000637633.2
ENST00000679459.1
ENST00000409888.1
ENST00000264167.11
ENST00000642466.2
AGPS
alkylglycerone phosphate synthase
chr9_-_16870662 0.68 ENST00000380672.9
BNC2
basonuclin 2
chr11_-_115504389 0.66 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
CADM1
cell adhesion molecule 1
chr1_+_42682388 0.60 ENST00000321358.12
ENST00000332220.10
YBX1
Y-box binding protein 1
chr7_-_27143672 0.56 ENST00000222726.4
HOXA5
homeobox A5
chr1_-_56579555 0.56 ENST00000371250.4
PLPP3
phospholipid phosphatase 3
chr9_+_113221528 0.54 ENST00000374212.5
SLC31A1
solute carrier family 31 member 1
chr12_+_55818033 0.53 ENST00000552672.5
ENST00000243045.10
ENST00000550836.1
ORMDL2
ORMDL sphingolipid biosynthesis regulator 2
chr11_+_68312542 0.53 ENST00000294304.12
LRP5
LDL receptor related protein 5
chr8_-_121641424 0.52 ENST00000303924.5
HAS2
hyaluronan synthase 2
chr16_+_56932134 0.51 ENST00000439977.7
ENST00000300302.9
ENST00000344114.8
ENST00000379792.6
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
chr14_-_29927801 0.51 ENST00000331968.11
PRKD1
protein kinase D1
chr13_-_78603539 0.50 ENST00000377208.7
POU4F1
POU class 4 homeobox 1
chr9_-_38069220 0.49 ENST00000377707.4
SHB
SH2 domain containing adaptor protein B
chr2_+_66435558 0.45 ENST00000488550.5
MEIS1
Meis homeobox 1
chr18_+_21363593 0.43 ENST00000580732.6
GREB1L
GREB1 like retinoic acid receptor coactivator
chr3_-_128650800 0.42 ENST00000296255.8
RPN1
ribophorin I
chr20_+_325536 0.41 ENST00000342665.5
SOX12
SRY-box transcription factor 12
chr8_+_60678705 0.40 ENST00000423902.7
CHD7
chromodomain helicase DNA binding protein 7
chr5_+_72816643 0.38 ENST00000337273.10
ENST00000523768.5
TNPO1
transportin 1
chr1_-_67430412 0.38 ENST00000370994.8
SERBP1
SERPINE1 mRNA binding protein 1
chr14_-_70416994 0.37 ENST00000621525.4
ENST00000256366.6
SYNJ2BP-COX16
SYNJ2BP
SYNJ2BP-COX16 readthrough
synaptojanin 2 binding protein
chr7_+_17298642 0.37 ENST00000242057.9
AHR
aryl hydrocarbon receptor
chr12_-_13981544 0.37 ENST00000609686.4
GRIN2B
glutamate ionotropic receptor NMDA type subunit 2B
chr7_+_101154445 0.36 ENST00000337619.11
ENST00000429457.1
AP1S1
adaptor related protein complex 1 subunit sigma 1
chr4_-_138242325 0.36 ENST00000280612.9
SLC7A11
solute carrier family 7 member 11
chr11_-_86955385 0.36 ENST00000531380.2
FZD4
frizzled class receptor 4
chr11_+_44095655 0.35 ENST00000684533.1
ENST00000683000.1
ENST00000395673.8
ENST00000682359.1
ENST00000533608.7
EXT2
exostosin glycosyltransferase 2
chr1_+_224356852 0.35 ENST00000366858.7
ENST00000366857.9
ENST00000465271.6
ENST00000366856.3
CNIH4
cornichon family AMPA receptor auxiliary protein 4
chr9_+_26956384 0.34 ENST00000518614.5
ENST00000380062.10
IFT74
intraflagellar transport 74
chr20_-_543770 0.34 ENST00000460062.7
ENST00000645187.1
ENST00000647348.1
ENST00000217244.9
ENST00000349736.10
CSNK2A1
casein kinase 2 alpha 1
chrX_+_74421450 0.34 ENST00000587091.6
SLC16A2
solute carrier family 16 member 2
chr8_-_115668966 0.34 ENST00000395715.8
TRPS1
transcriptional repressor GATA binding 1
chr2_+_46698909 0.33 ENST00000650611.1
ENST00000306503.5
LINC01118
SOCS5
long intergenic non-protein coding RNA 1118
suppressor of cytokine signaling 5
chr1_-_240612147 0.32 ENST00000318160.5
GREM2
gremlin 2, DAN family BMP antagonist
chr4_+_183099244 0.31 ENST00000403733.8
WWC2
WW and C2 domain containing 2
chr8_+_105318428 0.30 ENST00000407775.7
ZFPM2
zinc finger protein, FOG family member 2
chr16_+_86510507 0.30 ENST00000262426.6
FOXF1
forkhead box F1
chr19_+_34428353 0.29 ENST00000590048.6
ENST00000246548.9
UBA2
ubiquitin like modifier activating enzyme 2
chr9_-_107489754 0.29 ENST00000610832.1
ENST00000374672.5
KLF4
Kruppel like factor 4
chrX_-_101348676 0.29 ENST00000372902.4
ENST00000644112.2
TIMM8A
translocase of inner mitochondrial membrane 8A
chr9_-_124771304 0.28 ENST00000416460.6
ENST00000487099.7
NR6A1
nuclear receptor subfamily 6 group A member 1
chr22_-_41621014 0.27 ENST00000263256.7
DESI1
desumoylating isopeptidase 1
chr13_-_74133892 0.27 ENST00000377669.7
KLF12
Kruppel like factor 12
chrX_-_18672101 0.25 ENST00000379984.4
RS1
retinoschisin 1
chr19_+_19385815 0.24 ENST00000494516.6
ENST00000360315.7
GATAD2A
GATA zinc finger domain containing 2A
chr1_+_62437015 0.24 ENST00000339950.5
USP1
ubiquitin specific peptidase 1
chr12_+_20368495 0.24 ENST00000359062.4
PDE3A
phosphodiesterase 3A
chrX_+_96684801 0.22 ENST00000324765.13
DIAPH2
diaphanous related formin 2
chr9_+_74497308 0.21 ENST00000376896.8
RORB
RAR related orphan receptor B
chr17_-_44066595 0.20 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr17_+_30477362 0.20 ENST00000225724.9
ENST00000451249.7
ENST00000467337.6
ENST00000581721.5
ENST00000414833.2
GOSR1
golgi SNAP receptor complex member 1
chr1_+_2228310 0.20 ENST00000378536.5
SKI
SKI proto-oncogene
chr8_-_64798725 0.19 ENST00000310193.4
CYP7B1
cytochrome P450 family 7 subfamily B member 1
chr14_+_67241417 0.19 ENST00000556345.6
ENST00000555925.5
ENST00000261681.9
ENST00000557783.1
MPP5
membrane palmitoylated protein 5
chr3_+_185586270 0.18 ENST00000296257.10
SENP2
SUMO specific peptidase 2
chr1_+_3069160 0.18 ENST00000511072.5
PRDM16
PR/SET domain 16
chr14_+_74019341 0.17 ENST00000394009.5
ENST00000464394.5
BBOF1
basal body orientation factor 1
chr17_+_29043124 0.17 ENST00000323372.9
PIPOX
pipecolic acid and sarcosine oxidase
chr6_+_148747016 0.17 ENST00000367463.5
UST
uronyl 2-sulfotransferase
chr1_-_120069616 0.17 ENST00000652302.1
ENST00000652737.1
ENST00000256646.7
NOTCH2
notch receptor 2
chr14_-_54489003 0.16 ENST00000554908.5
ENST00000616146.4
GMFB
glia maturation factor beta
chr10_-_689613 0.15 ENST00000280886.12
ENST00000634311.1
DIP2C
disco interacting protein 2 homolog C
chr15_-_101252040 0.15 ENST00000254190.4
CHSY1
chondroitin sulfate synthase 1
chr12_+_53380639 0.14 ENST00000426431.2
SP1
Sp1 transcription factor
chr8_-_116755784 0.14 ENST00000518949.5
ENST00000522453.1
ENST00000518995.5
ENST00000521861.6
ENST00000611080.1
EIF3H
eukaryotic translation initiation factor 3 subunit H
chr4_-_82373946 0.14 ENST00000352301.8
ENST00000509107.1
ENST00000353341.8
ENST00000313899.12
HNRNPD
heterogeneous nuclear ribonucleoprotein D
chr2_-_74178802 0.14 ENST00000396049.5
MOB1A
MOB kinase activator 1A
chr12_-_120369156 0.13 ENST00000257552.7
MSI1
musashi RNA binding protein 1
chrX_+_56232343 0.13 ENST00000468660.6
KLF8
Kruppel like factor 8
chr7_-_105876575 0.13 ENST00000318724.8
ENST00000419735.8
ATXN7L1
ataxin 7 like 1
chr4_-_119628791 0.13 ENST00000354960.8
PDE5A
phosphodiesterase 5A
chr3_+_137764296 0.13 ENST00000306087.3
SOX14
SRY-box transcription factor 14
chr20_+_20368096 0.13 ENST00000310227.3
INSM1
INSM transcriptional repressor 1
chr1_-_205631962 0.12 ENST00000289703.8
ENST00000357992.9
ELK4
ETS transcription factor ELK4
chr1_+_15526813 0.12 ENST00000375838.5
ENST00000616884.4
ENST00000375849.5
ENST00000375847.8
DNAJC16
DnaJ heat shock protein family (Hsp40) member C16
chr21_-_36990198 0.11 ENST00000427746.1
ENST00000336648.8
HLCS
holocarboxylase synthetase
chr2_-_171894227 0.11 ENST00000422440.7
SLC25A12
solute carrier family 25 member 12
chr11_+_120336357 0.10 ENST00000397843.7
ARHGEF12
Rho guanine nucleotide exchange factor 12
chr2_+_118088432 0.10 ENST00000245787.9
INSIG2
insulin induced gene 2
chr19_-_663174 0.10 ENST00000292363.10
ENST00000589762.5
RNF126
ring finger protein 126
chr5_-_59893718 0.10 ENST00000340635.11
PDE4D
phosphodiesterase 4D
chr7_-_519239 0.09 ENST00000354513.9
ENST00000402802.7
PDGFA
platelet derived growth factor subunit A
chr1_+_200027702 0.08 ENST00000367362.8
NR5A2
nuclear receptor subfamily 5 group A member 2
chr14_-_67816574 0.07 ENST00000677026.1
ENST00000555452.1
ENST00000347230.9
ENST00000678386.1
ENST00000676620.1
ENST00000676512.1
ZFYVE26
zinc finger FYVE-type containing 26
chr2_+_132416795 0.07 ENST00000329321.4
GPR39
G protein-coupled receptor 39
chr9_+_4679555 0.07 ENST00000381858.5
ENST00000381854.4
CDC37L1
cell division cycle 37 like 1
chr10_+_100462969 0.06 ENST00000343737.6
WNT8B
Wnt family member 8B
chr14_-_96363333 0.05 ENST00000359933.6
ATG2B
autophagy related 2B
chr7_-_44885446 0.05 ENST00000395699.5
PURB
purine rich element binding protein B
chrX_+_70444855 0.05 ENST00000194900.8
DLG3
discs large MAGUK scaffold protein 3
chr1_-_21050952 0.03 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr2_-_178072751 0.03 ENST00000286063.11
PDE11A
phosphodiesterase 11A
chr13_+_50909745 0.03 ENST00000422660.6
ENST00000645188.1
ENST00000646731.1
ENST00000643774.1
ENST00000646960.1
ENST00000637648.2
ENST00000336617.8
RNASEH2B
ribonuclease H2 subunit B
chr10_+_100745711 0.02 ENST00000370296.6
ENST00000428433.5
PAX2
paired box 2
chr17_+_79778135 0.02 ENST00000310942.9
ENST00000269399.5
CBX2
chromobox 2
chr17_-_62065248 0.02 ENST00000397786.7
MED13
mediator complex subunit 13
chr9_-_23821275 0.02 ENST00000380110.8
ELAVL2
ELAV like RNA binding protein 2
chr5_+_175478551 0.01 ENST00000321442.10
ENST00000502393.5
ENST00000506963.1
SFXN1
sideroflexin 1
chr7_+_92528769 0.01 ENST00000481551.5
ENST00000265732.10
ENST00000496410.1
RBM48
RNA binding motif protein 48
chr17_+_14301069 0.01 ENST00000360954.3
HS3ST3B1
heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr17_-_51120855 0.01 ENST00000618113.4
ENST00000357122.8
ENST00000262013.12
SPAG9
sperm associated antigen 9
chr2_+_222861005 0.01 ENST00000680147.1
ENST00000681009.1
ENST00000679514.1
ENST00000357430.8
ACSL3
acyl-CoA synthetase long chain family member 3
chr1_-_10796636 0.01 ENST00000377022.8
ENST00000344008.5
CASZ1
castor zinc finger 1
chr5_+_140401808 0.00 ENST00000616482.4
ENST00000297183.10
ENST00000360839.7
ENST00000421134.5
ENST00000394723.7
ENST00000511151.5
ANKHD1
ankyrin repeat and KH domain containing 1
chr2_+_241702027 0.00 ENST00000313552.11
ENST00000406941.5
ING5
inhibitor of growth family member 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0032912 negative regulation of transforming growth factor beta2 production(GO:0032912)
0.2 0.7 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 0.7 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.2 0.9 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.2 0.6 GO:0060435 bronchiole development(GO:0060435)
0.2 0.5 GO:0090155 negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060)
0.2 3.0 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.2 0.5 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 0.5 GO:0060283 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.1 0.8 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 1.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 1.0 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.5 GO:0070295 renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.9 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.1 0.8 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.3 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.1 0.7 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.3 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.1 0.1 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.1 0.5 GO:0072719 copper ion import(GO:0015677) cellular response to cisplatin(GO:0072719)
0.1 0.4 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.3 GO:0048371 lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370) lateral mesodermal cell differentiation(GO:0048371) mesenchyme migration(GO:0090131)
0.1 0.5 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.2 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.0 0.1 GO:0071072 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) negative regulation of phospholipid biosynthetic process(GO:0071072) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0 0.2 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.0 0.6 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:1901355 response to rapamycin(GO:1901355)
0.0 0.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.2 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.7 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.5 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.8 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.9 GO:0043586 tongue development(GO:0043586)
0.0 0.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0071110 protein biotinylation(GO:0009305) histone biotinylation(GO:0071110)
0.0 0.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.5 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 1.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.3 GO:0009642 response to light intensity(GO:0009642)
0.0 0.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.5 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 0.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.3 GO:0097470 ribbon synapse(GO:0097470)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.1 0.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.5 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 3.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 1.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2 0.5 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.2 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.4 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 0.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415) ER retention sequence binding(GO:0046923)
0.1 0.6 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.2 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.4 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.7 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.3 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 1.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.3 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.2 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 0.1 GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.0 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.3 GO:0036122 BMP binding(GO:0036122)
0.0 0.7 GO:0071949 FAD binding(GO:0071949)
0.0 0.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.4 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis